aminopropionitrile has been researched along with Abnormalities, Drug-Induced in 28 studies
Aminopropionitrile: Reagent used as an intermediate in the manufacture of beta-alanine and pantothenic acid.
Abnormalities, Drug-Induced: Congenital abnormalities caused by medicinal substances or drugs of abuse given to or taken by the mother, or to which she is inadvertently exposed during the manufacture of such substances. The concept excludes abnormalities resulting from exposure to non-medicinal chemicals in the environment.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Kyphoscoliosis was produced in a high incidence in the fetuses at the level of the upper thoracic spine as early as 24 hours after treatment." | 5.26 | Congenital kyphoscoliosis and spinal cord lesion produced in the rat by beta-aminopropionitrile. ( Nogami, H; Oohira, A; Tamaki, K; Terashima, Y, 1977) |
| "Cleft palate was induced in 420 embryos of Sprague-Dawley rats with a single oral dose of 600 mg/kg beta-aminoproprionitrile (BAPN) on embryonal day 15, 7 hours." | 1.28 | Diagnosis of induced cleft palate in rats from defective patterns of differentiation of isoenzymes. ( Granström, G; Jacobsson, C; Kirkeby, S, 1992) |
| "The joint toxic action of three binary mixtures was determined for the embryo malformation endpoint of the aquatic FETAX (frog embryo teratogenesis assay: Xenopus) test system." | 1.28 | Initial evaluation of developmental malformation as an end point in mixture toxicity hazard assessment for aquatic vertebrates. ( Dawson, DA; Wilke, TS, 1991) |
| "Kyphoscoliosis was produced in a high incidence in the fetuses at the level of the upper thoracic spine as early as 24 hours after treatment." | 1.26 | Congenital kyphoscoliosis and spinal cord lesion produced in the rat by beta-aminopropionitrile. ( Nogami, H; Oohira, A; Tamaki, K; Terashima, Y, 1977) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 24 (85.71) | 18.7374 |
| 1990's | 3 (10.71) | 18.2507 |
| 2000's | 1 (3.57) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Dawson, DA | 3 |
| Rinaldi, AC | 1 |
| Pöch, G | 1 |
| Joneja, MG | 4 |
| Wiley, MJ | 3 |
| Kochhar, DM | 1 |
| Gibson, KD | 1 |
| Segen, BJ | 1 |
| Doller, HJ | 1 |
| Nogami, H | 1 |
| Terashima, Y | 1 |
| Tamaki, K | 1 |
| Oohira, A | 1 |
| Gabler, W | 1 |
| Brachmann, J | 1 |
| Dörfler, HP | 1 |
| Schmidt, W | 1 |
| Granström, G | 1 |
| Jacobsson, C | 1 |
| Kirkeby, S | 1 |
| Wilke, TS | 2 |
| Posner, HS | 1 |
| King, CT | 2 |
| Horigan, E | 1 |
| Wilk, AL | 2 |
| Barrow, MV | 4 |
| Steffek, AJ | 5 |
| Trnavský, K | 1 |
| Trnavská, Z | 1 |
| Abramovich, A | 1 |
| Hendrickx, AG | 1 |
| Simpson, CF | 2 |
| Miller, EJ | 1 |
| Joós, A | 1 |
| Kádár, A | 1 |
| Jellinek, H | 1 |
| Verrusio, AC | 1 |
| Watkins, CA | 1 |
| Horigan, EA | 1 |
| Hall, BK | 1 |
| Willis, LS | 1 |
| Stivers, FE | 2 |
| Steffer, AJ | 1 |
| Yarington, CT | 2 |
| Roll, R | 1 |
| Bär, F | 1 |
1 review available for aminopropionitrile and Abnormalities, Drug-Induced
| Article | Year |
|---|---|
Lathyrism: a review.
Topics: Abnormalities, Drug-Induced; Amino Acid Oxidoreductases; Aminopropionitrile; Aneurysm; Animals; Aort | 1974 |
27 other studies available for aminopropionitrile and Abnormalities, Drug-Induced
| Article | Year |
|---|---|
Biochemical and toxicological evaluation of agent-cofactor reactivity as a mechanism of action for osteolathyrism.
Topics: Abnormalities, Drug-Induced; Aminoacetonitrile; Aminopropionitrile; Animals; Bone Diseases; Collagen | 2002 |
Inhibition of beta-aminopropionitrile (beta APN)-induced skeletal teratogenesis by the flavonoid beta-hydroxyethylrutosides (HR) in hamster fetuses.
Topics: Abnormalities, Drug-Induced; Aminopropionitrile; Animals; Bone and Bones; Collagen; Cricetinae; Fema | 1982 |
Teratogenic effects of proline analogue L-azetidine-2-carboxylic acid in hamster fetuses.
Topics: Abnormalities, Drug-Induced; Aminopropionitrile; Animals; Azetidinecarboxylic Acid; Azetines; Bone a | 1981 |
The use of in vitro procedures in teratology.
Topics: Abnormalities, Drug-Induced; Aminopropionitrile; Aminopterin; Animals; Azaserine; Bromodeoxyuridine; | 1975 |
Changes in chemical composition of chick embryos treated with a beta-xyloside and a lathyrogen.
Topics: Abnormalities, Drug-Induced; Aminopropionitrile; Animals; Body Weight; Chick Embryo; Chondroitin Sul | 1979 |
Congenital kyphoscoliosis and spinal cord lesion produced in the rat by beta-aminopropionitrile.
Topics: Abnormalities, Drug-Induced; Aminopropionitrile; Animals; Cartilage; Collagen; Female; Kyphosis; Pre | 1977 |
[Action mechanism of various teratogenic lathyrogens].
Topics: Abnormalities, Drug-Induced; Acetonitriles; Aminoacetonitrile; Aminopropionitrile; Animals; Chemical | 1977 |
The morphogenesis of beta-aminopropionitrile-induced rib malformation in fetal golden Syrian hamsters.
Topics: Abnormalities, Drug-Induced; Aminopropionitrile; Animals; Cartilage; Collagen; Cricetinae; Female; G | 1978 |
The teratogenic effects of beta-aminopropionitrile in hamsters.
Topics: Abnormalities, Drug-Induced; Aminopropionitrile; Animals; Connective Tissue; Cricetinae; Dose-Respon | 1976 |
Diagnosis of induced cleft palate in rats from defective patterns of differentiation of isoenzymes.
Topics: Abnormalities, Drug-Induced; Aminopropionitrile; Amniotic Fluid; Animals; Cleft Palate; Clinical Enz | 1992 |
Joint toxic action of binary mixtures of osteolathyrogens at malformation-inducing concentrations for Xenopus embryos.
Topics: Abnormalities, Drug-Induced; Aminopropionitrile; Animals; Bone and Bones; Drug Synergism; Penicillam | 1991 |
Initial evaluation of developmental malformation as an end point in mixture toxicity hazard assessment for aquatic vertebrates.
Topics: Abnormalities, Drug-Induced; Aminopropionitrile; Animals; Butyrates; Embryo, Nonmammalian; Isoniazid | 1991 |
Significance of cleft palate induced by chemicals in the rat and mouse.
Topics: Abnormalities, Drug-Induced; Aminopropionitrile; Animals; Cleft Palate; Cortisone; Female; Mice; Nit | 1972 |
Fetal outcome from prolonged versus acute drug administration in the pregnant rat.
Topics: Abnormalities, Drug-Induced; Aminopropionitrile; Animals; Cleft Palate; Collagen; Demyelinating Dise | 1972 |
Teratologic and other embryotoxic effects of beta-aminopropionitrile in rats.
Topics: Abdominal Muscles; Abnormalities, Drug-Induced; Aminopropionitrile; Animals; Body Weight; Bone and B | 1974 |
The effect of antirheumatic drugs on the extractable collagen in lathyric chick embryos.
Topics: Abnormalities, Drug-Induced; Aminopropionitrile; Animals; Chick Embryo; Chloroquine; Collagen; Hydro | 1968 |
[Teratogenic effect of 2 principles of Lathyrus adoratus: beta-aminopropionitrile and aminoacetonitrile].
Topics: Abnormalities, Drug-Induced; Aminopropionitrile; Animals; Mandible; Maxillofacial Development; Nitri | 1972 |
Lathyrogen-induced malformations in baboons: a preliminary report.
Topics: Abnormalities, Drug-Induced; Aminopropionitrile; Animals; Bone and Bones; Cesarean Section; Cleft Pa | 1972 |
[Changes caused by copper deficient diet and beta amino propionitrile administration in chickens].
Topics: Abnormalities, Drug-Induced; Aminopropionitrile; Animals; Aorta; Chick Embryo; Chickens; Copper; Die | 1974 |
Cleft palate in rodents after maternal treatment with various lathyrogenic agents.
Topics: Abnormalities, Drug-Induced; Aminopropionitrile; Animal Feed; Animals; Cleft Palate; Female; Nitrile | 1972 |
Metabolism of -aminopropionitrile and its teratogenic activity in rats.
Topics: Abnormalities, Drug-Induced; Administration, Oral; Aminopropionitrile; Animals; Carbon Isotopes; Cle | 1972 |
Skeletal defects in embryonic chicks induced by administration of beta-aminopropionitrile.
Topics: Abnormalities, Drug-Induced; Alkaline Phosphatase; Aminopropionitrile; Animals; Body Weight; Bone an | 1972 |
Caution against the use of lathyrogens.
Topics: Abnormalities, Drug-Induced; Aminopropionitrile; Aneurysm; Animals; Arteriosclerosis; Bone Diseases; | 1972 |
Ectopia cordis (ectocardia) and gastroschisis induced in rats by maternal administration of the lathyrogen, beta-aminopropionitrile (BAPN).
Topics: Abdomen; Abnormalities, Drug-Induced; Aminopropionitrile; Animals; Female; Fetus; Gestational Age; H | 1972 |
The effect of lathyrogens on developing mid-facial structures in the rat.
Topics: Abnormalities, Drug-Induced; Aminopropionitrile; Animals; Diet; Female; Jaw Abnormalities; Lathyrism | 1970 |
The effect of lathyrogens on developing midfacial structures in the rat.
Topics: Abnormalities, Drug-Induced; Aminopropionitrile; Animals; Cartilage; Cleft Palate; Diet; Face; Femal | 1971 |
[Studies on the teratogenic effect of beta-aminopropionitril in pregnant female mice].
Topics: Abnormalities, Drug-Induced; Aminopropionitrile; Animals; Bone and Bones; Embryo, Mammalian; Embryon | 1968 |