aminooxyacetic acid has been researched along with Huntington Disease in 2 studies
Aminooxyacetic Acid: A compound that inhibits aminobutyrate aminotransferase activity in vivo, thereby raising the level of gamma-aminobutyric acid in tissues.
(aminooxy)acetic acid : A member of the class of hydroxylamines that is acetic acid substituted at postion 2 by an aminooxy group. It is a compound which inhibits aminobutyrate aminotransferase activity in vivo, resulting in increased levels of gamma-aminobutyric acid in tissues.
Huntington Disease: A familial disorder inherited as an autosomal dominant trait and characterized by the onset of progressive CHOREA and DEMENTIA in the fourth or fifth decade of life. Common initial manifestations include paranoia; poor impulse control; DEPRESSION; HALLUCINATIONS; and DELUSIONS. Eventually intellectual impairment; loss of fine motor control; ATHETOSIS; and diffuse chorea involving axial and limb musculature develops, leading to a vegetative state within 10-15 years of disease onset. The juvenile variant has a more fulminant course including SEIZURES; ATAXIA; dementia; and chorea. (From Adams et al., Principles of Neurology, 6th ed, pp1060-4)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Seven patients with Huntington disease were treated with aminooxyacetic acid (AOAA), an inhibitor of gamma-aminobutyric acid aminotransferase (GABA-T), in an effort to alleviate symptoms by increasing brain GABA content." | 9.05 | Failure of aminooxyacetic acid therapy in Huntington disease. ( Allan, BM; Baird, PA; Hansen, S; MacLeod, PM; Perry, TL; Wright, JM, 1980) |
| "Seven patients with Huntington disease were treated with aminooxyacetic acid (AOAA), an inhibitor of gamma-aminobutyric acid aminotransferase (GABA-T), in an effort to alleviate symptoms by increasing brain GABA content." | 5.05 | Failure of aminooxyacetic acid therapy in Huntington disease. ( Allan, BM; Baird, PA; Hansen, S; MacLeod, PM; Perry, TL; Wright, JM, 1980) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (100.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Perry, TL | 2 |
| Wright, JM | 1 |
| Hansen, S | 2 |
| Allan, BM | 1 |
| Baird, PA | 1 |
| MacLeod, PM | 1 |
1 trial available for aminooxyacetic acid and Huntington Disease
| Article | Year |
|---|---|
Failure of aminooxyacetic acid therapy in Huntington disease.
Topics: Acetates; Adult; Amino Acids; Aminooxyacetic Acid; Double-Blind Method; Female; Humans; Huntington D | 1980 |
1 other study available for aminooxyacetic acid and Huntington Disease
| Article | Year |
|---|---|
Biochemical effects in man and rat of three drugs which can increase brain GABA content.
Topics: Acetates; Adult; Amino Acids; Aminobutyrates; Aminooxyacetic Acid; Animals; Brain; gamma-Aminobutyri | 1978 |