aminooxyacetic acid has been researched along with Epilepsy in 8 studies
Aminooxyacetic Acid: A compound that inhibits aminobutyrate aminotransferase activity in vivo, thereby raising the level of gamma-aminobutyric acid in tissues.
(aminooxy)acetic acid : A member of the class of hydroxylamines that is acetic acid substituted at postion 2 by an aminooxy group. It is a compound which inhibits aminobutyrate aminotransferase activity in vivo, resulting in increased levels of gamma-aminobutyric acid in tissues.
Epilepsy: A disorder characterized by recurrent episodes of paroxysmal brain dysfunction due to a sudden, disorderly, and excessive neuronal discharge. Epilepsy classification systems are generally based upon: (1) clinical features of the seizure episodes (e.g., motor seizure), (2) etiology (e.g., post-traumatic), (3) anatomic site of seizure origin (e.g., frontal lobe seizure), (4) tendency to spread to other structures in the brain, and (5) temporal patterns (e.g., nocturnal epilepsy). (From Adams et al., Principles of Neurology, 6th ed, p313)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Three drugs which increase GABA-mediated inhibitory neurotransmission in the brain, namely the GABA degradation inhibitors aminooxyacetic acid (AOAA) and gamma-acetylenic GABA (GAG), and the GABA receptor agonist THIP (gaboxadol), were administered to epilepsy-prone gerbils via subcutaneously implanted osmotic minipumps for 2 weeks." | 3.67 | Development of tolerance to the anticonvulsant effect of GABAmimetic drugs in genetically epilepsy-prone gerbils. ( Löscher, W, 1986) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (37.50) | 18.7374 |
| 1990's | 3 (37.50) | 18.2507 |
| 2000's | 2 (25.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Barna, B | 1 |
| Szász, A | 1 |
| Asztalos, T | 1 |
| Szupera, Z | 1 |
| Vécsei, L | 1 |
| Houtzager, H | 1 |
| Szente, M | 1 |
| Du, F | 2 |
| Eid, T | 2 |
| Schwarcz, R | 2 |
| Fukao, K | 1 |
| Momiyama, T | 1 |
| Ishihara, K | 1 |
| Ujihara, H | 1 |
| Fujita, Y | 1 |
| Taniyama, K | 1 |
| Serikawa, T | 1 |
| Sasa, M | 1 |
| Sutch, RJ | 1 |
| Davies, CC | 1 |
| Bowery, NG | 1 |
| Greer, CA | 1 |
| Alpern, HP | 1 |
| Löscher, W | 1 |
| Kamphuis, W | 1 |
| Wadman, WJ | 1 |
| Buijs, RM | 1 |
| Lopes da Silva, FH | 1 |
1 review available for aminooxyacetic acid and Epilepsy
| Article | Year |
|---|---|
Neurons in layer III of the entorhinal cortex. A role in epileptogenesis and epilepsy?
Topics: Aminooxyacetic Acid; Animals; Entorhinal Cortex; Epilepsy; Injections; Neurons; Neurons, Afferent | 2000 |
7 other studies available for aminooxyacetic acid and Epilepsy
| Article | Year |
|---|---|
Concentration- and time-dependent effect of aminooxyacetic acid on cortical epileptogenicity.
Topics: Aminooxyacetic Acid; Animals; Dose-Response Relationship, Drug; Epilepsy; Evoked Potentials; Female; | 2002 |
Neuronal damage after the injection of aminooxyacetic acid into the rat entorhinal cortex: a silver impregnation study.
Topics: Aminooxyacetic Acid; Animals; Behavior, Animal; Entorhinal Cortex; Enzyme Inhibitors; Epilepsy; Male | 1998 |
Inhibition by gamma-aminobutyric acid system activation of epileptic seizures in spontaneously epileptic rats.
Topics: 4-Aminobutyrate Transaminase; Aminooxyacetic Acid; Animals; Brain; Electroencephalography; Enzyme In | 1998 |
GABA release and uptake measured in crude synaptosomes from Genetic Absence Epilepsy Rats from Strasbourg (GAERS).
Topics: Aminooxyacetic Acid; Animals; Autoradiography; beta-Alanine; Cerebral Cortex; Epilepsy; GABA Agents; | 1999 |
Differential neurohumoral modulation of myoclonic and clonic seizures.
Topics: Aminooxyacetic Acid; Animals; Bicuculline; Dopamine; Epilepsies, Myoclonic; Epilepsy; Fenclonine; ga | 1978 |
Development of tolerance to the anticonvulsant effect of GABAmimetic drugs in genetically epilepsy-prone gerbils.
Topics: Acetates; Alkynes; Aminocaproates; Aminooxyacetic Acid; Animals; Anticonvulsants; Brain; Diazepam; D | 1986 |
The development of changes in hippocampal GABA immunoreactivity in the rat kindling model of epilepsy: a light microscopic study with GABA antibodies.
Topics: Action Potentials; Aminooxyacetic Acid; Animals; Cell Count; Electric Stimulation; Epilepsy; gamma-A | 1987 |