aminooxyacetic acid has been researched along with Disease Models, Animal in 21 studies
Aminooxyacetic Acid: A compound that inhibits aminobutyrate aminotransferase activity in vivo, thereby raising the level of gamma-aminobutyric acid in tissues.
(aminooxy)acetic acid : A member of the class of hydroxylamines that is acetic acid substituted at postion 2 by an aminooxy group. It is a compound which inhibits aminobutyrate aminotransferase activity in vivo, resulting in increased levels of gamma-aminobutyric acid in tissues.
Disease Models, Animal: Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Hydrogen sulfide (H2S) plays multiple roles in the function of the central nervous system in physiological and pathological conditions, such as cerebral ischemia." | 7.81 | Effect of the Inhibition of Hydrogen Sulfide Synthesis on Ischemic Injury and Oxidative Stress Biomarkers in a Transient Model of Focal Cerebral Ischemia in Rats. ( Bandegi, AR; Hadadha, M; Vakili, A, 2015) |
| "In septic rats pretreated with AOAA, sepsis-associated hippocampus inflammation was reduced." | 5.37 | Effects of hydrogen sulfide on a rat model of sepsis-associated encephalopathy. ( Chen, D; Lan, X; Li, C; Liu, B; Pan, H; Yang, G, 2011) |
| "Mefloquine dose dependently induced tonic seizures in mice." | 5.33 | Gamma-aminobutyric acid and mefloquine-induced seizures in mice. ( Amabeoku, GJ; Farmer, CC, 2005) |
| "Penicillin seizures do not cause a change in levels of GABA, but result in a decrease in glutamate within the focus." | 5.26 | Effect of amino-oxyacetic acid (AOAA) on focal penicillin seizures. ( Collins, RC; Mehta, S, 1978) |
| "Hydrogen sulfide (H2S) plays multiple roles in the function of the central nervous system in physiological and pathological conditions, such as cerebral ischemia." | 3.81 | Effect of the Inhibition of Hydrogen Sulfide Synthesis on Ischemic Injury and Oxidative Stress Biomarkers in a Transient Model of Focal Cerebral Ischemia in Rats. ( Bandegi, AR; Hadadha, M; Vakili, A, 2015) |
| "Seven GABAmimetic drugs, namely cetyl gamma-aminobutyric acid (cetyl GABA), 4,5,6,7-tetrahydroisoxazolo [5,4-c]pyridine-3-ol, progabide, aminooxyacetic acid, alpha-acetylenic GABA, (-)-nipecotic acid ethyl ester and (+/-)-cis-4-hydroxynipecotic acid methyl ester, were tested for their potency to block "major" (generalized clonic-tonic) seizures in gerbils, induced by blowing at the animals with compressed air." | 3.66 | High anticonvulsant potency of gamma-aminobutyric acid (GABA)mimetic drugs in gerbils with genetically determined epilepsy. ( Frey, HH; Löscher, W; Reiche, R; Schultz, D, 1983) |
| "Prenatal treatment of Down syndrome fetuses is also suggested." | 1.51 | Mental retardation in Down syndrome: Two ways to treat. ( Kamoun, PP, 2019) |
| "Bladder pain is a prominent symptom of interstitial cystitis/painful bladder syndrome." | 1.48 | Endogenous H ( Bo, Q; Cui, J; Du, J; Shi, B; Wang, W; Wang, Y; Yu, X; Zhao, H; Zhu, K; Zhu, Y, 2018) |
| "In septic rats pretreated with AOAA, sepsis-associated hippocampus inflammation was reduced." | 1.37 | Effects of hydrogen sulfide on a rat model of sepsis-associated encephalopathy. ( Chen, D; Lan, X; Li, C; Liu, B; Pan, H; Yang, G, 2011) |
| "Mefloquine dose dependently induced tonic seizures in mice." | 1.33 | Gamma-aminobutyric acid and mefloquine-induced seizures in mice. ( Amabeoku, GJ; Farmer, CC, 2005) |
| "Penicillin seizures do not cause a change in levels of GABA, but result in a decrease in glutamate within the focus." | 1.26 | Effect of amino-oxyacetic acid (AOAA) on focal penicillin seizures. ( Collins, RC; Mehta, S, 1978) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 8 (38.10) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (14.29) | 29.6817 |
| 2010's | 8 (38.10) | 24.3611 |
| 2020's | 2 (9.52) | 2.80 |
| Authors | Studies |
|---|---|
| Solinski, HJ | 1 |
| Dranchak, P | 1 |
| Oliphant, E | 1 |
| Gu, X | 1 |
| Earnest, TW | 1 |
| Braisted, J | 1 |
| Inglese, J | 1 |
| Hoon, MA | 1 |
| Abrams, RPM | 1 |
| Yasgar, A | 1 |
| Teramoto, T | 1 |
| Lee, MH | 1 |
| Dorjsuren, D | 1 |
| Eastman, RT | 1 |
| Malik, N | 1 |
| Zakharov, AV | 1 |
| Li, W | 2 |
| Bachani, M | 1 |
| Brimacombe, K | 1 |
| Steiner, JP | 1 |
| Hall, MD | 1 |
| Balasubramanian, A | 1 |
| Jadhav, A | 1 |
| Padmanabhan, R | 1 |
| Simeonov, A | 1 |
| Nath, A | 1 |
| Yu, J | 1 |
| Jin, B | 1 |
| Zhang, H | 1 |
| Zhang, J | 1 |
| Kamoun, PP | 1 |
| Wang, W | 1 |
| Bo, Q | 1 |
| Du, J | 1 |
| Yu, X | 1 |
| Zhu, K | 1 |
| Cui, J | 1 |
| Zhao, H | 1 |
| Wang, Y | 1 |
| Shi, B | 1 |
| Zhu, Y | 1 |
| da Silva, GS | 1 |
| Soriano, RN | 1 |
| Kwiatkoski, M | 1 |
| Giusti, H | 1 |
| Glass, ML | 1 |
| Branco, LG | 1 |
| Hadadha, M | 1 |
| Vakili, A | 1 |
| Bandegi, AR | 1 |
| Babizhayev, MA | 1 |
| Guiotto, A | 1 |
| Kasus-Jacobi, A | 1 |
| Wakefield, SL | 1 |
| Lane, M | 1 |
| Mitchell, M | 1 |
| Chen, D | 1 |
| Pan, H | 1 |
| Li, C | 1 |
| Lan, X | 1 |
| Liu, B | 1 |
| Yang, G | 1 |
| Takeda, A | 1 |
| Iwaki, H | 1 |
| Ide, K | 1 |
| Tamano, H | 1 |
| Oku, N | 1 |
| Amabeoku, GJ | 1 |
| Farmer, CC | 1 |
| Petkov, O | 2 |
| Löscher, W | 1 |
| Frey, HH | 1 |
| Reiche, R | 1 |
| Schultz, D | 1 |
| Hamat, RB | 1 |
| Wolman, SL | 1 |
| Fields, AL | 1 |
| Sonnenberg, KL | 1 |
| Cheema-Dhadli, S | 1 |
| Halperin, ML | 1 |
| Frieder, B | 1 |
| Karpiak, SE | 1 |
| Rapport, MM | 1 |
| Novelli, M | 1 |
| Fabregat, ME | 1 |
| Fernandez-Alvarez, J | 1 |
| Gomis, R | 1 |
| Masiello, P | 1 |
| Collins, RC | 1 |
| Mehta, S | 1 |
| Battista, AF | 1 |
| Goldstein, M | 1 |
| Miyamoto, T | 1 |
| Matsumoto, Y | 1 |
| Borsini, F | 1 |
| Mancinelli, A | 1 |
| D'Aranno, V | 1 |
| Evangelista, S | 1 |
| Meli, A | 1 |
| Orbetsova, V | 1 |
| Dakovska, L | 1 |
1 trial available for aminooxyacetic acid and Disease Models, Animal
| Article | Year |
|---|---|
N-Acetylcarnosine and histidyl-hydrazide are potent agents for multitargeted ophthalmic therapy of senile cataracts and diabetic ocular complications.
Topics: Aged; Aged, 80 and over; Aldehydes; Aminooxyacetic Acid; Animals; Biological Availability; Carnosine | 2009 |
20 other studies available for aminooxyacetic acid and Disease Models, Animal
| Article | Year |
|---|---|
Inhibition of natriuretic peptide receptor 1 reduces itch in mice.
Topics: Animals; Behavior, Animal; Cell-Free System; Dermatitis, Contact; Disease Models, Animal; Ganglia, S | 2019 |
Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
Topics: Animals; Antiviral Agents; Artificial Intelligence; Chlorocebus aethiops; Disease Models, Animal; Dr | 2020 |
Protective Effects of Aminooxyacetic Acid on Colitis Induced in Mice with Dextran Sulfate Sodium.
Topics: Aminooxyacetic Acid; Animals; Colitis; Dextran Sulfate; Disease Models, Animal; GABA Agents; Humans; | 2021 |
Mental retardation in Down syndrome: Two ways to treat.
Topics: Aminooxyacetic Acid; Animals; Benserazide; Brain; Chromosomes, Human, Pair 21; Cobamides; Cystathion | 2019 |
Endogenous H
Topics: Alkynes; Aminooxyacetic Acid; Analgesics; Animals; Cell Line; Cystathionine gamma-Lyase; Cystitis, I | 2018 |
Central hydrogen sulphide mediates ventilatory responses to hypercapnia in adult conscious rats.
Topics: Aging; Aminooxyacetic Acid; Animals; Cystathionine beta-Synthase; Cystathionine gamma-Lyase; Disease | 2014 |
Effect of the Inhibition of Hydrogen Sulfide Synthesis on Ischemic Injury and Oxidative Stress Biomarkers in a Transient Model of Focal Cerebral Ischemia in Rats.
Topics: Aminooxyacetic Acid; Animals; Biomarkers; Brain; Brain Ischemia; Disease Models, Animal; Enzyme Inhi | 2015 |
Impaired mitochondrial function in the preimplantation embryo perturbs fetal and placental development in the mouse.
Topics: Aminooxyacetic Acid; Animals; Blastocyst; Cells, Cultured; Disease Models, Animal; Embryo Culture Te | 2011 |
Effects of hydrogen sulfide on a rat model of sepsis-associated encephalopathy.
Topics: Aminooxyacetic Acid; Animals; Brain Diseases; Cystathionine beta-Synthase; Cytokines; Disease Models | 2011 |
Therapeutic effect of Yokukansan on social isolation-induced aggressive behavior of zinc-deficient and pair-fed mice.
Topics: Aggression; Aminooxyacetic Acid; Analysis of Variance; Animals; Disease Models, Animal; Dizocilpine | 2012 |
Gamma-aminobutyric acid and mefloquine-induced seizures in mice.
Topics: Acetanilides; Aminooxyacetic Acid; Animals; Anti-Anxiety Agents; Chi-Square Distribution; Disease Mo | 2005 |
Some functional changes in experimentally induced cardiac overload.
Topics: Aminooxyacetic Acid; Animals; Atropine; Cardiomegaly; Disease Models, Animal; Drug Combinations; Ele | 1983 |
High anticonvulsant potency of gamma-aminobutyric acid (GABA)mimetic drugs in gerbils with genetically determined epilepsy.
Topics: Alkynes; Aminocaproates; Aminooxyacetic Acid; Animals; Anticonvulsants; Diazepam; Disease Models, An | 1983 |
Evaluation of sodium acetate as a source of alkali therapy in an experimental aerobic model of lactic acidosis due to decreased pyruvate oxidation.
Topics: Acetates; Acidosis; Aminooxyacetic Acid; Animals; Coumaric Acids; Disease Models, Animal; Glucose; L | 1982 |
Effect of antiepileptic drugs and an anticonvulsant on epileptiform activity induced by antibodies to ganglioside.
Topics: Action Potentials; Aminooxyacetic Acid; Animals; Anticonvulsants; Cobalt; Diazepam; Disease Models, | 1982 |
Metabolic and functional studies on isolated islets in a new rat model of type 2 diabetes.
Topics: Aminooxyacetic Acid; Animals; Diabetes Mellitus, Type 2; Disease Models, Animal; Glucose; Glycerolph | 2001 |
Effect of amino-oxyacetic acid (AOAA) on focal penicillin seizures.
Topics: Acetates; Alanine; Aminooxyacetic Acid; Animals; Aspartic Acid; Cerebral Cortex; Disease Models, Ani | 1978 |
Effect of centrally acting drugs on experimental torticollis in monkeys.
Topics: Acetates; Alkaloids; Aminooxyacetic Acid; Animals; Brain Stem; Chlorocebus aethiops; Disease Models, | 1976 |
On the role of endogenous GABA in the forced swimming test in rats.
Topics: Aminooxyacetic Acid; Animals; Brain; Depression; Disease Models, Animal; gamma-Aminobutyric Acid; Ma | 1988 |
Changes in blood plasma and myocardial lipids in experimental thyrotoxic myocardial hypertrophy in rabbits.
Topics: Aminooxyacetic Acid; Animals; Cardiomyopathy, Hypertrophic; Cholesterol; Disease Models, Animal; Fat | 1985 |