aminomethyltransferase and Leukemia--T-Cell

Analysis of genomic sequence from canine chromosome 20q15.1-->q15.2 revealed the presence of two closely linked genes. The two genes represent the corresponding canine orthologs of human aminomethyltransferase (AMT) and the human T-cell leukemia translocation associated (TCTA) gene. Aminomethyltransferase or glycine cleavage system T-protein is an important enzyme in glycine metabolism. The reported canine AMT gene spans 5 kb and consists of nine exons. It encodes a protein of 403 amino acids with 88% identity to human aminomethyltransferase. Human TCTA is located on 3p21 near the breakpoint of a t(1;3) translocation observed in some cancer cell lines. The 4-kb canine TCTA gene consists of three exons and probably represents a pseudogene. It is located adjacent to AMT and very close to DAG1 and BSN.

Topics: Aminomethyltransferase; Animals; Base Sequence; Cloning, Molecular; Codon, Initiator; Dogs; Exons; Genetic Linkage; Humans; Hydroxymethyl and Formyl Transferases; Introns; Leukemia, T-Cell; Molecular Sequence Data; Physical Chromosome Mapping; Promoter Regions, Genetic; Pseudogenes; Sequence Homology, Nucleic Acid; Translocation, Genetic