aminomethyltransferase and Intellectual-Disability

aminomethyltransferase has been researched along with Intellectual-Disability* in 1 studies

Other Studies

1 other study(ies) available for aminomethyltransferase and Intellectual-Disability

Article	Year
Difficulties in assessing the effect of strychnine on the outcome of non-ketotic hyperglycinaemia. Observations on sisters with a mild T-protein defect. European journal of pediatrics, 1986, Volume: 145, Issue:4 Sisters with a mild variant of non-ketotic hyperglycinaemia resulting from a defect in the T-protein of the glycine cleavage system had different clinical outcomes. The older sister was ascertained at 6 months of age because of mental retardation. She received only brief treatment with sodium benzoate from 11-15 months and at 15 years of age is profoundly retarded and has epilepsy. The younger sister was diagnosed 36 h after birth, was treated with strychnine, sodium benzoate and arginine from the neonatal period and at 27 months of age is only moderately retarded and free of seizures. The possible role of strychnine in the improved outcome is discussed. Topics: Adolescent; Aminomethyltransferase; Arginine; Benzoates; Benzoic Acid; Child, Preschool; Drug Evaluation; Drug Therapy, Combination; Female; Glycine; Humans; Hydroxymethyl and Formyl Transferases; Intellectual Disability; Strychnine; Time Factors; Transferases	1986

Article

Year

Difficulties in assessing the effect of strychnine on the outcome of non-ketotic hyperglycinaemia. Observations on sisters with a mild T-protein defect.

European journal of pediatrics, 1986, Volume: 145, Issue:4

Sisters with a mild variant of non-ketotic hyperglycinaemia resulting from a defect in the T-protein of the glycine cleavage system had different clinical outcomes. The older sister was ascertained at 6 months of age because of mental retardation. She received only brief treatment with sodium benzoate from 11-15 months and at 15 years of age is profoundly retarded and has epilepsy. The younger sister was diagnosed 36 h after birth, was treated with strychnine, sodium benzoate and arginine from the neonatal period and at 27 months of age is only moderately retarded and free of seizures. The possible role of strychnine in the improved outcome is discussed.

Topics: Adolescent; Aminomethyltransferase; Arginine; Benzoates; Benzoic Acid; Child, Preschool; Drug Evaluation; Drug Therapy, Combination; Female; Glycine; Humans; Hydroxymethyl and Formyl Transferases; Intellectual Disability; Strychnine; Time Factors; Transferases

1986