aminolevulinic acid has been researched along with Spinal Cord Neoplasms in 11 studies
Aminolevulinic Acid: A compound produced from succinyl-CoA and GLYCINE as an intermediate in heme synthesis. It is used as a PHOTOCHEMOTHERAPY for actinic KERATOSIS.
5-aminolevulinic acid : The simplest delta-amino acid in which the hydrogens at the gamma position are replaced by an oxo group. It is metabolised to protoporphyrin IX, a photoactive compound which accumulates in the skin. Used (in the form of the hydrochloride salt)in combination with blue light illumination for the treatment of minimally to moderately thick actinic keratosis of the face or scalp.
Spinal Cord Neoplasms: Benign and malignant neoplasms which occur within the substance of the spinal cord (intramedullary neoplasms) or in the space between the dura and spinal cord (intradural extramedullary neoplasms). The majority of intramedullary spinal tumors are primary CNS neoplasms including ASTROCYTOMA; EPENDYMOMA; and LIPOMA. Intramedullary neoplasms are often associated with SYRINGOMYELIA. The most frequent histologic types of intradural-extramedullary tumors are MENINGIOMA and NEUROFIBROMA.
| Excerpt | Relevance | Reference |
|---|---|---|
| "However, the effects of 5-ALA on spinal cord tumors remain unknown." | 5.39 | 5-aminolevulinic acid fluorescence-guided resection of intramedullary ependymoma: report of 9 cases. ( Endo, T; Inoue, T; Nagamatsu, K; Tominaga, T; Watanabe, M, 2013) |
| "Intramedullary spinal cord tumors (IMSCTs) are rare neoplasms and their management involves tumors resection in most cases." | 2.82 | Comparison of Effectiveness, Feasibility, Indications, and Limitations of Different Intraoperative Dyes in Spinal Neuro-Oncologic Surgery. A Systematic Review. ( Corbi, L; Della Pepa, GM; Mattogno, PP; Menna, G; Olivi, A; Pennisi, G; Polli, FM; Sturiale, CL, 2022) |
| "However, the effects of 5-ALA on spinal cord tumors remain unknown." | 1.39 | 5-aminolevulinic acid fluorescence-guided resection of intramedullary ependymoma: report of 9 cases. ( Endo, T; Inoue, T; Nagamatsu, K; Tominaga, T; Watanabe, M, 2013) |
| "We present a case of an anaplastic astrocytoma (WHO-grade III, AA III) in a 27-year-old woman treated by spinal cordectomy." | 1.36 | Cordectomy as final treatment option for diffuse intramedullary malignant glioma using 5-ALA fluorescence-guided resection. ( Ewelt, C; Felsberg, J; Klink, B; Sabel, M; Steiger, HJ; Stummer, W, 2010) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (18.18) | 29.6817 |
| 2010's | 8 (72.73) | 24.3611 |
| 2020's | 1 (9.09) | 2.80 |
| Authors | Studies |
|---|---|
| Mattogno, PP | 1 |
| Menna, G | 1 |
| Pennisi, G | 1 |
| Corbi, L | 1 |
| Sturiale, CL | 1 |
| Polli, FM | 1 |
| Olivi, A | 1 |
| Della Pepa, GM | 1 |
| Ruschel, LG | 1 |
| Ramina, R | 1 |
| da Silva, EB | 1 |
| Cavalcanti, MS | 1 |
| Duarte, JFS | 1 |
| Wainwright, JV | 1 |
| Endo, T | 2 |
| Cooper, JB | 1 |
| Tominaga, T | 2 |
| Schmidt, MH | 1 |
| Millesi, M | 1 |
| Kiesel, B | 1 |
| Woehrer, A | 1 |
| Hainfellner, JA | 2 |
| Novak, K | 1 |
| Martínez-Moreno, M | 1 |
| Wolfsberger, S | 1 |
| Knosp, E | 1 |
| Widhalm, G | 1 |
| Ewelt, C | 1 |
| Stummer, W | 1 |
| Klink, B | 1 |
| Felsberg, J | 1 |
| Steiger, HJ | 3 |
| Sabel, M | 2 |
| Haybaeck, J | 1 |
| von Campe, G | 1 |
| Inoue, T | 1 |
| Nagamatsu, K | 1 |
| Watanabe, M | 1 |
| Eicker, SO | 1 |
| Floeth, FW | 1 |
| Kamp, M | 1 |
| Hänggi, D | 1 |
| Arai, T | 1 |
| Tani, S | 1 |
| Isoshima, A | 1 |
| Nagashima, H | 1 |
| Joki, T | 1 |
| Takahashi-Fujigasaki, J | 1 |
| Abe, T | 1 |
| Shimizu, S | 1 |
| Utsuki, S | 1 |
| Sato, K | 1 |
| Oka, H | 1 |
| Fujii, K | 1 |
| Mii, K | 1 |
| Kamp, MA | 1 |
| Krause Molle, Z | 1 |
| Munoz-Bendix, C | 1 |
| Rapp, M | 1 |
| Cornelius, JF | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| 5-Aminolevulinic Acid (5-ALA) Gliolan®: Usage Increase Proposal for Neurosurgical Procedures in High-Grade Gliomas[NCT05850377] | 90 participants (Anticipated) | Observational | 2023-06-01 | Not yet recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
4 reviews available for aminolevulinic acid and Spinal Cord Neoplasms
| Article | Year |
|---|---|
Comparison of Effectiveness, Feasibility, Indications, and Limitations of Different Intraoperative Dyes in Spinal Neuro-Oncologic Surgery. A Systematic Review.
Topics: Aminolevulinic Acid; Feasibility Studies; Fluorescein; Fluorescent Dyes; Humans; Indocyanine Green; | 2022 |
The role of 5-aminolevulinic acid in spinal tumor surgery: a review.
Topics: Aminolevulinic Acid; Fluorescent Dyes; Humans; Optical Imaging; Protoporphyrins; Spinal Cord Neoplas | 2019 |
[Rapid frozen sections in neuropathology].
Topics: Aminolevulinic Acid; Biopsy; Brain; Brain Neoplasms; Frozen Sections; Humans; Magnetic Resonance Ima | 2012 |
Various shades of red-a systematic analysis of qualitative estimation of ALA-derived fluorescence in neurosurgery.
Topics: Aminolevulinic Acid; Brain Neoplasms; Color; Evaluation Studies as Topic; Fluorescence; Fluorescent | 2018 |
1 trial available for aminolevulinic acid and Spinal Cord Neoplasms
| Article | Year |
|---|---|
The impact of fluorescence guidance on spinal intradural tumour surgery.
Topics: Aged; Aged, 80 and over; Aminolevulinic Acid; Female; Fluorescence; Fluorescent Dyes; Humans; Male; | 2013 |
6 other studies available for aminolevulinic acid and Spinal Cord Neoplasms
| Article | Year |
|---|---|
5-Aminolevulinic acid fluorescence-guided surgery for spinal cord melanoma metastasis: a technical note.
Topics: Adult; Aminolevulinic Acid; Brain Neoplasms; Ependymoma; Female; Fluorescent Dyes; Humans; Male; Mel | 2018 |
Analysis of 5-aminolevulinic acid-induced fluorescence in 55 different spinal tumors.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aminolevulinic Acid; Female; Fluorescent Dyes; Follow-Up | 2014 |
Cordectomy as final treatment option for diffuse intramedullary malignant glioma using 5-ALA fluorescence-guided resection.
Topics: Adult; Aminolevulinic Acid; Astrocytoma; Cordotomy; Female; Humans; Magnetic Resonance Imaging; Neur | 2010 |
5-aminolevulinic acid fluorescence-guided resection of intramedullary ependymoma: report of 9 cases.
Topics: Adult; Aminolevulinic Acid; Ependymoma; Female; Fluorescent Dyes; Humans; Intraoperative Period; Mal | 2013 |
[Intraoperative photodynamic diagnosis for spinal ependymoma using 5-aminolevulinic acid: technical note].
Topics: Adult; Aminolevulinic Acid; Ependymoma; Female; Fluorescence; Humans; Intraoperative Period; Lightin | 2006 |
Photodynamic diagnosis in surgery for spinal ependymoma. Case illustration.
Topics: Adult; Aminolevulinic Acid; Ependymoma; Humans; Male; Photosensitizing Agents; Spectrometry, Fluores | 2006 |