Page last updated: 2024-10-16

aminolevulinic acid and Rosacea

aminolevulinic acid has been researched along with Rosacea in 8 studies

Aminolevulinic Acid: A compound produced from succinyl-CoA and GLYCINE as an intermediate in heme synthesis. It is used as a PHOTOCHEMOTHERAPY for actinic KERATOSIS.
5-aminolevulinic acid : The simplest delta-amino acid in which the hydrogens at the gamma position are replaced by an oxo group. It is metabolised to protoporphyrin IX, a photoactive compound which accumulates in the skin. Used (in the form of the hydrochloride salt)in combination with blue light illumination for the treatment of minimally to moderately thick actinic keratosis of the face or scalp.

Rosacea: A cutaneous disorder primarily of convexities of the central part of the FACE, such as FOREHEAD; CHEEK; NOSE; and CHIN. It is characterized by FLUSHING; ERYTHEMA; EDEMA; RHINOPHYMA; papules; and ocular symptoms. It may occur at any age but typically after age 30. There are various subtypes of rosacea: erythematotelangiectatic, papulopustular, phymatous, and ocular (National Rosacea Society's Expert Committee on the Classification and Staging of Rosacea, J Am Acad Dermatol 2002; 46:584-7).

Research Excerpts

ExcerptRelevanceReference
"5-Aminolevulinic acid photodynamic therapy (ALA-PDT) showed potential to treat rosacea according to recent studies; however, a lack of clinical evidence and unclear adverse effects limit its use."9.695-Aminolevulinic acid photodynamic therapy versus minocycline for moderate-to-severe rosacea: A single-center, randomized, evaluator-blind controlled study. ( Cao, Y; Chen, Q; Liu, X; Wang, P; Wang, X; Yang, J; Yang, Y; Zeng, Q; Zhang, H; Zhang, L, 2023)
"To compare the effect of ALA-PDT vs minocycline on rosacea."9.695-Aminolevulinic acid photodynamic therapy versus minocycline for moderate-to-severe rosacea: A single-center, randomized, evaluator-blind controlled study. ( Cao, Y; Chen, Q; Liu, X; Wang, P; Wang, X; Yang, J; Yang, Y; Zeng, Q; Zhang, H; Zhang, L, 2023)
"In this single-center, randomized, evaluator-blind, controlled study, patients with moderate-to-severe rosacea were allocated to receive 3 to 5 sessions of ALA-PDT or 8 weeks of 100 mg daily minocycline treatment, followed by a 24-week follow-up."9.695-Aminolevulinic acid photodynamic therapy versus minocycline for moderate-to-severe rosacea: A single-center, randomized, evaluator-blind controlled study. ( Cao, Y; Chen, Q; Liu, X; Wang, P; Wang, X; Yang, J; Yang, Y; Zeng, Q; Zhang, H; Zhang, L, 2023)
"As minocycline does, ALA-PDT can improve rosacea mainly in papulopustular lesions and patients' quality of life, indicating a new option for rosacea."9.695-Aminolevulinic acid photodynamic therapy versus minocycline for moderate-to-severe rosacea: A single-center, randomized, evaluator-blind controlled study. ( Cao, Y; Chen, Q; Liu, X; Wang, P; Wang, X; Yang, J; Yang, Y; Zeng, Q; Zhang, H; Zhang, L, 2023)
"A 72-year-old woman suffering from multiple actinic keratosis (AK) complicating steroid-induced rosacea received 5-aminolevulinic acid-photodynamic therapy (ALA-PDT) in our outpatient clinic."8.12Inflammation burst after 5-aminolevulinic acid-photodynamic therapy for the treatment of actinic keratosis complicating rosacea: A case report. ( Cao, Y; Hu, C; Liu, P; Liu, X; Wang, P; Wang, X; Yang, X; Zhang, L, 2022)
"5-Aminolevulinic acid photodynamic therapy (ALA-PDT) showed potential to treat rosacea according to recent studies; however, a lack of clinical evidence and unclear adverse effects limit its use."5.695-Aminolevulinic acid photodynamic therapy versus minocycline for moderate-to-severe rosacea: A single-center, randomized, evaluator-blind controlled study. ( Cao, Y; Chen, Q; Liu, X; Wang, P; Wang, X; Yang, J; Yang, Y; Zeng, Q; Zhang, H; Zhang, L, 2023)
"To compare the effect of ALA-PDT vs minocycline on rosacea."5.695-Aminolevulinic acid photodynamic therapy versus minocycline for moderate-to-severe rosacea: A single-center, randomized, evaluator-blind controlled study. ( Cao, Y; Chen, Q; Liu, X; Wang, P; Wang, X; Yang, J; Yang, Y; Zeng, Q; Zhang, H; Zhang, L, 2023)
"In this single-center, randomized, evaluator-blind, controlled study, patients with moderate-to-severe rosacea were allocated to receive 3 to 5 sessions of ALA-PDT or 8 weeks of 100 mg daily minocycline treatment, followed by a 24-week follow-up."5.695-Aminolevulinic acid photodynamic therapy versus minocycline for moderate-to-severe rosacea: A single-center, randomized, evaluator-blind controlled study. ( Cao, Y; Chen, Q; Liu, X; Wang, P; Wang, X; Yang, J; Yang, Y; Zeng, Q; Zhang, H; Zhang, L, 2023)
"As minocycline does, ALA-PDT can improve rosacea mainly in papulopustular lesions and patients' quality of life, indicating a new option for rosacea."5.695-Aminolevulinic acid photodynamic therapy versus minocycline for moderate-to-severe rosacea: A single-center, randomized, evaluator-blind controlled study. ( Cao, Y; Chen, Q; Liu, X; Wang, P; Wang, X; Yang, J; Yang, Y; Zeng, Q; Zhang, H; Zhang, L, 2023)
"A 72-year-old woman suffering from multiple actinic keratosis (AK) complicating steroid-induced rosacea received 5-aminolevulinic acid-photodynamic therapy (ALA-PDT) in our outpatient clinic."4.12Inflammation burst after 5-aminolevulinic acid-photodynamic therapy for the treatment of actinic keratosis complicating rosacea: A case report. ( Cao, Y; Hu, C; Liu, P; Liu, X; Wang, P; Wang, X; Yang, X; Zhang, L, 2022)
"Rosacea is a common chronic cutaneous disorder which is characterized by flushing, erythema, papulopustules and telangiectasia."2.87Photodynamic therapy for rosacea in Chinese patients. ( Fan, L; Hamblin, MR; Lan, T; Yin, R, 2018)
"Rosacea is a common disease that often has a chronic intermittent course despite current treatment; therefore, additional treatment options are desirable."1.34Photodynamic therapy in a series of rosacea patients. ( Bryld, LE; Jemec, GB, 2007)

Research

Studies (8)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's2 (25.00)29.6817
2010's3 (37.50)24.3611
2020's3 (37.50)2.80

Authors

AuthorsStudies
Li, A1
Fang, R1
Mao, X1
Sun, Q1
Liu, P1
Liu, X2
Wang, P2
Zhang, L2
Hu, C1
Yang, X1
Cao, Y2
Wang, X2
Yang, J1
Zhang, H1
Chen, Q1
Yang, Y1
Zeng, Q1
Sun, Y1
Chen, L1
Zhang, Y1
Gao, X1
Wu, Y1
Chen, H1
Fan, L1
Yin, R1
Lan, T1
Hamblin, MR1
Friedmann, DP1
Goldman, MP1
Fabi, SG1
Guiha, I1
Katz, B1
Patel, V1
Bryld, LE1
Jemec, GB1

Reviews

1 review available for aminolevulinic acid and Rosacea

ArticleYear
Photodynamic therapy in the treatment of rosacea: A systematic review.
    Photodiagnosis and photodynamic therapy, 2022, Volume: 38

    Topics: Adolescent; Adult; Aged; Aminolevulinic Acid; Humans; Lasers, Dye; Light; Middle Aged; Photochemothe

2022

Trials

2 trials available for aminolevulinic acid and Rosacea

ArticleYear
5-Aminolevulinic acid photodynamic therapy versus minocycline for moderate-to-severe rosacea: A single-center, randomized, evaluator-blind controlled study.
    Journal of the American Academy of Dermatology, 2023, Volume: 89, Issue:4

    Topics: Aminolevulinic Acid; Humans; Minocycline; Photochemotherapy; Photosensitizing Agents; Quality of Lif

2023
Photodynamic therapy for rosacea in Chinese patients.
    Photodiagnosis and photodynamic therapy, 2018, Volume: 24

    Topics: Adult; Aminolevulinic Acid; Asian People; China; Emulsions; Female; Humans; Male; Middle Aged; Photo

2018

Other Studies

5 other studies available for aminolevulinic acid and Rosacea

ArticleYear
Inflammation burst after 5-aminolevulinic acid-photodynamic therapy for the treatment of actinic keratosis complicating rosacea: A case report.
    Photodiagnosis and photodynamic therapy, 2022, Volume: 39

    Topics: Aged; Aminolevulinic Acid; Female; Humans; Hyperpigmentation; Inflammation; Keratosis, Actinic; Phot

2022
Topical photodynamic therapy with 5-aminolevulinic acid in Chinese patients with Rosacea.
    Journal of cosmetic and laser therapy : official publication of the European Society for Laser Dermatology, 2019, Volume: 21, Issue:4

    Topics: Adult; Aminolevulinic Acid; China; Female; Humans; Male; Middle Aged; Patient Satisfaction; Photoche

2019
Multiple sequential light and laser sources to activate aminolevulinic acid for rosacea.
    Journal of cosmetic dermatology, 2016, Volume: 15, Issue:4

    Topics: Aminolevulinic Acid; Color; Female; Humans; Intense Pulsed Light Therapy; Lasers, Dye; Male; Middle

2016
Photodynamic therapy for the treatment of erythema, papules, pustules, and severe flushing consistent with rosacea.
    Journal of drugs in dermatology : JDD, 2006, Volume: 5, Issue:2 Suppl

    Topics: Aminolevulinic Acid; Erythema; Female; Flushing; Humans; Middle Aged; Photochemotherapy; Photosensit

2006
Photodynamic therapy in a series of rosacea patients.
    Journal of the European Academy of Dermatology and Venereology : JEADV, 2007, Volume: 21, Issue:9

    Topics: Adult; Aged; Aminolevulinic Acid; Dermatologic Agents; Female; Humans; Male; Middle Aged; Photochemo

2007