aminolevulinic acid has been researched along with Protoporphyria, Erythropoietic in 10 studies
Aminolevulinic Acid: A compound produced from succinyl-CoA and GLYCINE as an intermediate in heme synthesis. It is used as a PHOTOCHEMOTHERAPY for actinic KERATOSIS.
5-aminolevulinic acid : The simplest delta-amino acid in which the hydrogens at the gamma position are replaced by an oxo group. It is metabolised to protoporphyrin IX, a photoactive compound which accumulates in the skin. Used (in the form of the hydrochloride salt)in combination with blue light illumination for the treatment of minimally to moderately thick actinic keratosis of the face or scalp.
Protoporphyria, Erythropoietic: An autosomal dominant porphyria that is due to a deficiency of FERROCHELATASE (heme synthetase) in both the LIVER and the BONE MARROW, the last enzyme in the 8-enzyme biosynthetic pathway of HEME. Clinical features include mainly neurological symptoms, rarely cutaneous lesions, and elevated levels of protoporphyrin and COPROPORPHYRINS in the feces.
| Excerpt | Relevance | Reference |
|---|---|---|
| " These findings suggest that the amount of protoporphyrin IX accumulation from ALA reflects the extent of deficiency of ferrochelatase and is proportional to the dosage of abnormal EPP gene in cultured fibroblasts." | 5.26 | Accumulation of protoporphyrin IX from delta-aminolevulinic acid in bovine skin fibroblasts with hereditary erythropoietic protoporphyria. A gene-dosage effect. ( Ruth, G; Sassa, S; Schwartz, S, 1981) |
| "Fibroblasts from cattle homozygous for erythropoietic protoporphyria (EPP) and with the clinical symptoms of the disease accumulated approximately sixfold greater amounts of protoporphyrin IX than cells from normal control animals." | 5.26 | Accumulation of protoporphyrin IX from delta-aminolevulinic acid in bovine skin fibroblasts with hereditary erythropoietic protoporphyria. A gene-dosage effect. ( Ruth, G; Sassa, S; Schwartz, S, 1981) |
| "In this paper we show that the ferrochelatase defect in erythropoietic protoporphyria (EPP) can readily be identified in mitogen-stimulated lymphocytes since such cells from patients with EPP accumulate approximately twice as much protoporphyrin IX as cells from normal subjects when incubated with a porphyrin precursor, gamma-aminolevulinic acid (ALA)." | 3.66 | Studies in porphyria: functional evidence for a partial deficiency of ferrochelatase activity in mitogen-stimulated lymphocytes from patients with erythropoietic protoporphyria. ( Anderson, KE; Kappas, A; Poh-Fitzpatrick, MB; Sassa, S; Zalar, GL, 1982) |
| " These findings suggest that the amount of protoporphyrin IX accumulation from ALA reflects the extent of deficiency of ferrochelatase and is proportional to the dosage of abnormal EPP gene in cultured fibroblasts." | 1.26 | Accumulation of protoporphyrin IX from delta-aminolevulinic acid in bovine skin fibroblasts with hereditary erythropoietic protoporphyria. A gene-dosage effect. ( Ruth, G; Sassa, S; Schwartz, S, 1981) |
| "Fibroblasts from cattle homozygous for erythropoietic protoporphyria (EPP) and with the clinical symptoms of the disease accumulated approximately sixfold greater amounts of protoporphyrin IX than cells from normal control animals." | 1.26 | Accumulation of protoporphyrin IX from delta-aminolevulinic acid in bovine skin fibroblasts with hereditary erythropoietic protoporphyria. A gene-dosage effect. ( Ruth, G; Sassa, S; Schwartz, S, 1981) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (50.00) | 18.7374 |
| 1990's | 1 (10.00) | 18.2507 |
| 2000's | 2 (20.00) | 29.6817 |
| 2010's | 2 (20.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Fratz, EJ | 1 |
| Clayton, J | 1 |
| Hunter, GA | 1 |
| Ducamp, S | 1 |
| Breydo, L | 1 |
| Uversky, VN | 1 |
| Deybach, JC | 1 |
| Gouya, L | 1 |
| Puy, H | 1 |
| Ferreira, GC | 1 |
| Elenbaas, JS | 1 |
| Maitra, D | 1 |
| Liu, Y | 1 |
| Lentz, SI | 1 |
| Nelson, B | 1 |
| Hoenerhoff, MJ | 1 |
| Shavit, JA | 1 |
| Omary, MB | 1 |
| Pischik, E | 1 |
| Kauppinen, R | 1 |
| Sassa, S | 3 |
| Schwartz, S | 1 |
| Ruth, G | 1 |
| Zalar, GL | 2 |
| Poh-Fitzpatrick, MB | 2 |
| Anderson, KE | 1 |
| Kappas, A | 2 |
| Romeo, G | 1 |
| Nakayashiki, T | 1 |
| Inokuchi, H | 1 |
| Moretti, MB | 1 |
| Garcia, SC | 1 |
| Batlle, A | 1 |
| Chan, KM | 1 |
| Ladenson, JH | 1 |
| Vaidya, HC | 1 |
| Kanan, R | 1 |
1 review available for aminolevulinic acid and Protoporphyria, Erythropoietic
| Article | Year |
|---|---|
The hepatic porphyrias.
Topics: 5-Aminolevulinate Synthetase; Acute Disease; Adolescent; Adult; Aminolevulinic Acid; Chemical Phenom | 1980 |
9 other studies available for aminolevulinic acid and Protoporphyria, Erythropoietic
| Article | Year |
|---|---|
Human Erythroid 5-Aminolevulinate Synthase Mutations Associated with X-Linked Protoporphyria Disrupt the Conformational Equilibrium and Enhance Product Release.
Topics: 5-Aminolevulinate Synthetase; Aminolevulinic Acid; Enzyme Stability; Escherichia coli; Genetic Disea | 2015 |
A precursor-inducible zebrafish model of acute protoporphyria with hepatic protein aggregation and multiorganelle stress.
Topics: Aminolevulinic Acid; Animals; Deferoxamine; Disease Models, Animal; Genetic Predisposition to Diseas | 2016 |
Lead poisoning from the beauty case: neurologic manifestations in an elderly woman.
Topics: Aged; Aminolevulinic Acid; Anemia, Macrocytic; Causality; Diagnostic Errors; Erythrocytes; Female; H | 2008 |
Accumulation of protoporphyrin IX from delta-aminolevulinic acid in bovine skin fibroblasts with hereditary erythropoietic protoporphyria. A gene-dosage effect.
Topics: Aminolevulinic Acid; Animals; Cattle; Edetic Acid; Erythropoiesis; Fibroblasts; Iron; Levulinic Acid | 1981 |
Studies in porphyria: functional evidence for a partial deficiency of ferrochelatase activity in mitogen-stimulated lymphocytes from patients with erythropoietic protoporphyria.
Topics: Adolescent; Adult; Aminolevulinic Acid; Cells, Cultured; Child; Edetic Acid; Female; Genetic Carrier | 1982 |
Effects of starvation for heme on the synthesis of porphyrins in Escherichia coli.
Topics: Aldehyde Oxidoreductases; Aminolevulinic Acid; Butanols; Escherichia coli; Gene Expression Regulatio | 1997 |
Porphyrin biosynthesis intermediates are not regulating delta-aminolevulinic acid transport in Saccharomyces cerevisiae.
Topics: 5-Aminolevulinate Synthetase; Aminolevulinic Acid; Biological Transport; Ferrochelatase; GABA Plasma | 2000 |
Studies in porphyria IX: Detection of the gene defect of erythropoietic protoporphyria in mitogen-stimulated human lymphocytes.
Topics: Adolescent; Adult; Aminolevulinic Acid; Cells, Cultured; Female; Heterozygote; Humans; Lymphocyte Ac | 1979 |
Washington University case conference. Dual porphyria--an underdiagnosed entity?
Topics: Aminolevulinic Acid; Coproporphyrins; Diagnosis, Differential; Feces; Flavoproteins; Humans; Male; M | 1987 |