aminolevulinic acid has been researched along with Porphyrias in 238 studies
Aminolevulinic Acid: A compound produced from succinyl-CoA and GLYCINE as an intermediate in heme synthesis. It is used as a PHOTOCHEMOTHERAPY for actinic KERATOSIS.
5-aminolevulinic acid : The simplest delta-amino acid in which the hydrogens at the gamma position are replaced by an oxo group. It is metabolised to protoporphyrin IX, a photoactive compound which accumulates in the skin. Used (in the form of the hydrochloride salt)in combination with blue light illumination for the treatment of minimally to moderately thick actinic keratosis of the face or scalp.
Porphyrias: A diverse group of metabolic diseases characterized by errors in the biosynthetic pathway of HEME in the LIVER, the BONE MARROW, or both. They are classified by the deficiency of specific enzymes, the tissue site of enzyme defect, or the clinical features that include neurological (acute) or cutaneous (skin lesions). Porphyrias can be hereditary or acquired as a result of toxicity to the hepatic or erythropoietic marrow tissues.
| Excerpt | Relevance | Reference |
|---|---|---|
| " The assay is developed for use in the clinical diagnosis of delta-aminolevulinic acid dehydratase-deficient porphyria, a rare enzymatic deficiency of the heme biosynthetic pathway." | 7.76 | Direct assay of delta-aminolevulinic acid dehydratase in heme biosynthesis for the detection of porphyrias by tandem mass spectrometry. ( Choiniere, JR; Gelb, MH; Scott, CR; Turecek, F, 2010) |
| "5-Aminolevulinic acid (ALA), a heme precursor accumulated during the clinical expression of acute intermittent porphyria, lead poisoning, and tyrosinosis, has been hypothesized to act as an endogenous source of oxyradicals." | 7.69 | The prooxidant effect of 5-aminolevulinic acid in the brain tissue of rats: implications in neuropsychiatric manifestations in porphyrias. ( Bechara, EJ; DeLucia, R; Demasi, M; Penatti, CA, 1996) |
| "delta-Aminolevulinic acid is a heme precursor accumulated in acute intermittent porphyria and lead-poisoning, which supposedly triggers the typical clinical expression associated with these diseases." | 7.68 | Damage to rat liver mitochondria promoted by delta-aminolevulinic acid-generated reactive oxygen species: connections with acute intermittent porphyria and lead-poisoning. ( Bechara, EJ; Hermes-Lima, M; Valle, VG; Vercesi, AE, 1991) |
| "A 43-yr-old man with abdominal fullness was treated with oral cimetidine during remission of acute intermittent porphyria." | 7.67 | Clinical usefulness of cimetidine for the treatment of acute intermittent porphyria--a preliminary report. ( Hirayama, C; Horie, Y; Udagawa, M, 1987) |
| "In two male patients with acute hepatic porphyria and persisting paralysis which increased in intensity intermittently, the activity of porphobilinogen synthase (PBG-S; delta-aminolevulinic acid dehydr(at)ase) was diminished in peripheral erythrocytes and bone marrow cells below 3% of normal controls." | 7.66 | New type of acute porphyria with porphobilinogen synthase (delta-aminolevulinic acid dehydratase) defect in the homozygous state. ( Brandt, A; Doss, M; Schneider, J; Von Tiepermann, R, 1982) |
| "The effect of p-amino-benzoic (PAB) acid on the experimental hexachlorobenzene (HCB) induced hepatic porphyria of female Wistar rats was determined under different conditions: Neither a simultaneous HCB-PAB application (prophylactic administration) nor the PAB application after manifestation of the HCB-porphyria (therapeutic administration) influenced significantly the excretin of urinary porphyrins or precursors (porphobilinogen or 5-amino-levulinic acid)." | 7.66 | [Influence of p-amino-benzoic acid on the hexachlorobenzene induced porphyria in the rat (author's transl)]. ( Goerz, G; Krieg, T; Lissner, R; Sick, N; Vizethum, W, 1980) |
| "The effects of dietary manipulations on excretion of the porphyrin precursors, delta-aminolevulinic acid (ALA), and porphobilinogen (PBG) were studied in eight patients with acute intermittent porphyria." | 7.65 | Comparative effects of glycerol and dextrose on porphyrin precursor excretion in acute intermittent porphyria. ( Bonkowsky, HL; Collins, AR; Doherty, JM; Hess, RA; Magnussen, CR; Tschudy, DP, 1976) |
| " Hexachlorobenzene porphyria in the rat provides a suitable experimental model of the stages of development of human chronic hepatic porphyria." | 7.65 | Hexachlorobenzene porphyria in rats as a model for human chronic hepatic porphyrias. ( Doss, M; Koss, G; Schermuly, E, 1976) |
| "Symptoms of acute porphyria have been attributed to effects of delta-aminolevulinic acid (ALA)." | 7.65 | delta-Aminolevulinic acid: influences on synaptic GABA receptor binding may explain CNS symptoms of porphyria. ( Müller, WE; Snyder, SH, 1977) |
| "A patient who had hereditary tyrosinemia was observed during two illnesses to have characteristics of acute intermittent porphyria with associated hypertension." | 7.65 | Tyrosinemia with acute intermittent porphyria: aminolevulinic acid dehydratase deficiency related to elevated urinary aminolevulinic acid levels. ( Berry, HK; Emmett, EA; Finelli, VN; Petering, HG; Strife, CF; Zuroweste, EL, 1977) |
| "The excretion of delta-aminolevulinic acid and porphobilinogen in the urine of 31 patients with multiple sclerosis did not differ significantly from that of 51 hospitalized control patients or eight patients with poliomyelitis." | 7.64 | PORPHOBILINOGEN AND DELTA-AMINOLEVULINIC ACID EXCRETION IN MULTIPLE SCLEROSIS. ( MARKLE, V; PAZDER, LH; TAYLOR, JD, 1965) |
| " Further characterization of the transport system for uroporphyrin in this model is expected to benefit not only our understanding of the cellular mechanism for disposal of toxic soluble wastes but also potentially the effective management of human uroporphyria and the use of uroporphyric Leishmania for vaccine/drug delivery." | 5.35 | Transgenic Leishmania model for delta-aminolevulinate-inducible monospecific uroporphyria: cytolytic phototoxicity initiated by singlet oxygen-mediated inactivation of proteins and its ablation by endosomal mobilization of cytosolic uroporphyrin. ( Chang, KP; Dutta, S; Kolli, BK; Sassa, S; Tang, A, 2008) |
| "Porphyria has been associated with an increase in plasma levels of 5-aminolevulinic acid and porphobilinogen." | 5.29 | Altered 5-aminolevulinic acid metabolism leading to pseudoporphyria in hemodialysed patients. ( Del C Batlle, AM; Guolo, M; Melito, V; Parera, V; Stella, AM, 1996) |
| "Symptoms of acute porphyria have been attributed to effects of delta-aminolevulinic acid (ALA)." | 5.26 | delta-Aminolevulinic acid: influences on synaptic GABA receptor binding may explain CNS symptoms of porphyria. ( Müller, WE; Snyder, SH, 1977) |
| "Fibroblasts from cattle homozygous for erythropoietic protoporphyria (EPP) and with the clinical symptoms of the disease accumulated approximately sixfold greater amounts of protoporphyrin IX than cells from normal control animals." | 5.26 | Accumulation of protoporphyrin IX from delta-aminolevulinic acid in bovine skin fibroblasts with hereditary erythropoietic protoporphyria. A gene-dosage effect. ( Ruth, G; Sassa, S; Schwartz, S, 1981) |
| " After treatment with Resochin in an erroneously high dosage (1." | 5.26 | [Accident in treatment of porphyria cutanea tarda by chloroquine (Resochin) (author's transl)]. ( Eichenauer, MG; Goerz, G; Krieg, T, 1976) |
| "Clonazepam was ineffective in treating the seizures and, in high doses, seemed to exacerbate the porphyria." | 5.26 | Seizure management in acute hepatic porphyria: risks of valproate and clonazepam. ( Bonkowsky, HL; Emery, S; Sinclair, JF; Sinclair, PR, 1980) |
| "We studied one patient with major motor seizures and acute intermittent porphyria." | 5.26 | Seizure management in acute hepatic porphyria: risks of valproate and clonazepam. ( Bonkowsky, HL; Emery, S; Sinclair, JF; Sinclair, PR, 1980) |
| " These findings suggest that the amount of protoporphyrin IX accumulation from ALA reflects the extent of deficiency of ferrochelatase and is proportional to the dosage of abnormal EPP gene in cultured fibroblasts." | 5.26 | Accumulation of protoporphyrin IX from delta-aminolevulinic acid in bovine skin fibroblasts with hereditary erythropoietic protoporphyria. A gene-dosage effect. ( Ruth, G; Sassa, S; Schwartz, S, 1981) |
| " The drug was administered at a dosage of 200 mg t." | 5.26 | Danazol administration to females with menses-associated exacerbations of acute intermittent porphyria. ( Frykholm, BC; Herrera, W; Lamon, JM; Tschudy, DP, 1979) |
| "Whereas demyelination does occur in acute porphyria where the levels of delta-aminolevulinic acid and porphobilinogen are elevated, the converse is not true; that is, demyelination is not always associated with an increase in the excretion of porphobilinogen or delta-aminolevulinic acid." | 5.24 | PORPHOBILINOGEN AND DELTA-AMINOLEVULINIC ACID EXCRETION IN MULTIPLE SCLEROSIS. ( MARKLE, V; PAZDER, LH; TAYLOR, JD, 1965) |
| "We conclude that in some porphyric patients treatment with erythropoietin reduces urinary delta-aminolaevulinic acid, porphobilinogen and porphyrin levels with an increase in well-being and a reduction in the severity of porphyria attacks." | 5.10 | Erythropoietin treatment in the neuropsychiatric porphyrias. ( Chandler, G; Deacon, AC; Macdougall, IC; Marsden, JT; Peters, TJ; Winkler, AS, 2003) |
| "Porphyrias are a group of eight rare inherited metabolic disorders of heme biosynthesis pathway." | 4.86 | Porphyrias at a glance: diagnosis and treatment. ( Brancaleoni, V; Cappellini, MD; Di Pierro, E; Graziadei, G; Tavazzi, D, 2010) |
| "The acute hepatic porphyrias (AHPs) are inherited disorders of heme biosynthesis characterized by life-threatening acute neurovisceral attacks precipitated by factors that upregulate hepatic 5-aminolevulinic acid synthase 1 (ALAS1) activity." | 4.31 | RNA interference therapy in acute hepatic porphyrias. ( Balwani, M; Keel, S; Yasuda, M, 2023) |
| "The quantification of delta-aminolevulinic acid (ALA) and porphobilinogen (PBG) in urine are the first-line tests for diagnosis and monitoring of acute hepatic porphyrias (AHP)." | 4.31 | Quantification of Urine and Plasma Porphyrin Precursors Using LC-MS in Acute Hepatic Porphyrias: Improvement in Routine Diagnosis and in the Monitoring of Kidney Failure Patients. ( Dessendier, N; Gouya, L; Junot, C; Lefebvre, T; Manceau, H; Moulouel, B; Nguyen, AL; Poli, A; Puy, H; Schmitt, C; Talbi, N, 2023) |
| "Porphyria was induced in vivo in mice using 3,5-diethoxycarbonyl-1,4-dihydrocollidine or in vitro by exposing human liver Huh7 cells and keratinocytes, or their lysates, to protoporphyrin-IX, other porphyrins, or to δ-aminolevulinic acid plus deferoxamine." | 3.91 | Oxygen and Conformation Dependent Protein Oxidation and Aggregation by Porphyrins in Hepatocytes and Light-Exposed Cells. ( Basrur, V; Carter, EL; Herrmann, H; Lehnert, N; Maitra, D; Nesvizhskii, AI; Omary, MB; Osawa, Y; Ragsdale, SW; Richardson, R; Rittié, L; Wolf, MW; Zhang, H, 2019) |
| "Porphyrias are caused by porphyrin accumulation resulting from defects in the heme biosynthetic pathway that typically lead to photosensitivity and possible end-stage liver disease with an increased risk of hepatocellular carcinoma." | 3.91 | Oxygen and Conformation Dependent Protein Oxidation and Aggregation by Porphyrins in Hepatocytes and Light-Exposed Cells. ( Basrur, V; Carter, EL; Herrmann, H; Lehnert, N; Maitra, D; Nesvizhskii, AI; Omary, MB; Osawa, Y; Ragsdale, SW; Richardson, R; Rittié, L; Wolf, MW; Zhang, H, 2019) |
| " The assay is developed for use in the clinical diagnosis of delta-aminolevulinic acid dehydratase-deficient porphyria, a rare enzymatic deficiency of the heme biosynthetic pathway." | 3.76 | Direct assay of delta-aminolevulinic acid dehydratase in heme biosynthesis for the detection of porphyrias by tandem mass spectrometry. ( Choiniere, JR; Gelb, MH; Scott, CR; Turecek, F, 2010) |
| "5-Aminolevulinic acid (ALA) is a heme precursor that accumulates in lead poisoning and inborn porphyrias." | 3.71 | DNA damage by 3,6-dihydropyrazine-2,5-dipropanoic acid, the cyclic dimerization product of 5-aminolevulinic acid. ( Di Mascio, P; Dörnemann, D; Medeiros, MH; Onuki, J; Teixeira, PC, 2001) |
| "Cellular accumulation of 5-aminolevulinic acid (ALA), the first specific intermediate of heme biosynthesis, is correlated in liver biopsy samples of acute intermittent porphyria affected patients with an increase in the occurrence of hepatic cancers and the formation of ferritin deposits in hepatocytes." | 3.70 | DNA damage by 5-aminolevulinic and 4,5-dioxovaleric acids in the presence of ferritin. ( Cadet, J; Di Mascio, P; Dörnemann, D; Douki, T; Medeiros, MH; Onuki, J; Teixeira, PC, 2000) |
| "5-Aminolevulinic acid (ALA), a heme precursor accumulated during the clinical expression of acute intermittent porphyria, lead poisoning, and tyrosinosis, has been hypothesized to act as an endogenous source of oxyradicals." | 3.69 | The prooxidant effect of 5-aminolevulinic acid in the brain tissue of rats: implications in neuropsychiatric manifestations in porphyrias. ( Bechara, EJ; DeLucia, R; Demasi, M; Penatti, CA, 1996) |
| "In order to evaluate the possible therapeutical effects of reduced glutathione in subjects affected by acquired or congenital heme biosynthesis alterations, two groups of subjects have been considered: the first, of 5 subjects with abnormal lead absorption, the second of 10 patients suffering from porphyria cutanea tarda (PCT)." | 3.68 | [Evaluation of the effects of reduced glutathione in subjects with acquired and congenital changes in heme biosynthesis]. ( Alessio, L; Buizza, P; De Panfilis, G; De Vincentiis, A; Ferioli, A; Leali, C; Pasolini, G, 1992) |
| "5-Aminolevulinic acid (ALA), a heme precursor that accumulates in acute intermittent porphyria patients and lead-exposed individuals, has previously been shown to autoxidize with generation of reactive oxygen species and to cause in vitro oxidative damage to rat liver mitochondria." | 3.68 | 5-aminolevulinic acid-induced alterations of oxidative metabolism in sedentary and exercise-trained rats. ( Bechara, EJ; Curi, R; Kokubun, E; Pereira, B, 1992) |
| "The ability of 3,5-diethoxycarbonyl-1,4-dihydrocollidine (DDC), 3,5-diethoxycarbonyl-4-ethyl-1,4-dihydro-2,6-dimethylpyridine (EDDC) and griseofulvin to induce porphyria in primary cultures of mouse hepatocytes has been examined." | 3.68 | Inhibition of ferrochelatase and accumulation of porphyrins in mouse hepatocyte cultures exposed to porphyrinogenic chemicals. ( Brady, AM; Lock, EA, 1992) |
| " A provisional diagnosis of acute intermittent porphyria was made and was confirmed by the increased levels of urinary delta-aminolevulinic acid (ALA) and porphobilinogen (PBG)." | 3.68 | Acute intermittent porphyria. A perplexing case. ( Arena, A; Russo, P; Scuderi, D, 1992) |
| "delta-Aminolevulinic acid is a heme precursor accumulated in acute intermittent porphyria and lead-poisoning, which supposedly triggers the typical clinical expression associated with these diseases." | 3.68 | Damage to rat liver mitochondria promoted by delta-aminolevulinic acid-generated reactive oxygen species: connections with acute intermittent porphyria and lead-poisoning. ( Bechara, EJ; Hermes-Lima, M; Valle, VG; Vercesi, AE, 1991) |
| "The manifestations of the acute attack of an hepatic porphyria may result from the actions of the excessive amounts of delta-aminolevulinic acid (ALA) or porphobilinogen (PBG) that accumulate during the event." | 3.67 | Sorbent therapy of the porphyrias. III. Comparative efficacy of experimental plasma perfusion with several commercial hemoperfusion cartridges. ( Tishler, PV; Winston, SH, 1984) |
| "A simple qualitative procedure for demonstrating increased delta-aminolevulinic acid (ALA) in urine is needed to identify individuals with an inherited deficiency of the enzyme ALA dehydratase, a newly described porphyria-like syndrome." | 3.67 | Simple screening test for qualitative detection of increased delta-aminolevulinic acid in urine. ( Tishler, PV; Winston, SH, 1984) |
| "Rats were treated with the well-known porphyrogen hexachlorobenzene (HCB) to induce experimental porphyria." | 3.67 | Influence of chloroquine on the porphyrin metabolism. ( Bolsen, K; Goerz, G; Merk, H, 1985) |
| "delta-Aminolevulinic acid (ALA), a heme precursor accumulated in acute intermittent porphyria and saturnism, undergoes autoxidation leading to ammonium ion and probably the corresponding alpha-ketoaldehyde." | 3.67 | Free radical generation during delta-aminolevulinic acid autoxidation: induction by hemoglobin and connections with porphyrinpathies. ( Abdalla, DS; Augusto, O; Bechara, EJ; Monteiro, HP, 1989) |
| "Porphyria was induced in adult male Wistar rats starved for 24 hr by SC injection of 400 mg/kg allylisopropylacetamide (AIA)." | 3.67 | Endogenously formed norharman (beta-carboline) in platelet rich plasma obtained from porphyric rats. ( Bruinvels, J; Schouten, MJ, 1986) |
| "A 43-yr-old man with abdominal fullness was treated with oral cimetidine during remission of acute intermittent porphyria." | 3.67 | Clinical usefulness of cimetidine for the treatment of acute intermittent porphyria--a preliminary report. ( Hirayama, C; Horie, Y; Udagawa, M, 1987) |
| "Urinary excretion of porphyrin precursors delta-aminolevulinic acid (ALA) and porphobilinogen (PBG) and total porphyrins was measured during intoxication of rats with 2,4-dithiobiuret (DTB), a chemical which produces delayed-onset neuromuscular weakness, in an attempt to ascertain whether or not DTB poisoning in the rat would serve as an animal model of the neurologic symptoms of acute intermittent porphyria." | 3.67 | Excretion of porphyrins and porphyrin precursors during neuromuscular paralysis produced by dithiobiuret. ( Atchison, WD; Peterson, RE, 1984) |
| "It was investigated whether an increased demand for glycine, as postulated to occur in patients who have suffered from episodic psychoses accompanied by multiple perceptual distortions, could evoke psychotic reactions." | 3.66 | Serine and glycine-induced catalepsy in porphyric rats: an animal model for psychosis? ( Bruinvels, J; Pepplinkhuizen, L; Schouten, MJ; Wilson, JH, 1983) |
| "In two male patients with acute hepatic porphyria and persisting paralysis which increased in intensity intermittently, the activity of porphobilinogen synthase (PBG-S; delta-aminolevulinic acid dehydr(at)ase) was diminished in peripheral erythrocytes and bone marrow cells below 3% of normal controls." | 3.66 | New type of acute porphyria with porphobilinogen synthase (delta-aminolevulinic acid dehydratase) defect in the homozygous state. ( Brandt, A; Doss, M; Schneider, J; Von Tiepermann, R, 1982) |
| "The diagnosis of acute intermittent porphyria was made in 10 members of a large kindred because of increased excretion of porphobilinogen and delta-aminolevulinic acid in the urine but normal fecal porphyrins." | 3.66 | Normal erythrocyte uroporphyrinogen I synthase in a kindred with acute intermittent porphyria. ( Mustajoki, P, 1981) |
| "The effect of p-amino-benzoic (PAB) acid on the experimental hexachlorobenzene (HCB) induced hepatic porphyria of female Wistar rats was determined under different conditions: Neither a simultaneous HCB-PAB application (prophylactic administration) nor the PAB application after manifestation of the HCB-porphyria (therapeutic administration) influenced significantly the excretin of urinary porphyrins or precursors (porphobilinogen or 5-amino-levulinic acid)." | 3.66 | [Influence of p-amino-benzoic acid on the hexachlorobenzene induced porphyria in the rat (author's transl)]. ( Goerz, G; Krieg, T; Lissner, R; Sick, N; Vizethum, W, 1980) |
| "Numerous drugs and environmental chemicals are capable of influencing the clinical expression of human hepatic porphyria primarily by interfering with the orderly regulation of heme synthesis in the liver." | 3.66 | Environmental and drug factors in hepatic porphyria. ( Bickers, DR, 1982) |
| "In this paper we show that the ferrochelatase defect in erythropoietic protoporphyria (EPP) can readily be identified in mitogen-stimulated lymphocytes since such cells from patients with EPP accumulate approximately twice as much protoporphyrin IX as cells from normal subjects when incubated with a porphyrin precursor, gamma-aminolevulinic acid (ALA)." | 3.66 | Studies in porphyria: functional evidence for a partial deficiency of ferrochelatase activity in mitogen-stimulated lymphocytes from patients with erythropoietic protoporphyria. ( Anderson, KE; Kappas, A; Poh-Fitzpatrick, MB; Sassa, S; Zalar, GL, 1982) |
| "The effect of DL-propranolol on 3',5'-diethoxycarbonyl-1,4-dihydrocollidine-induced experimental porphyria was studied." | 3.65 | The effect of beta-adrenergic blocking agents on experimental porphyria induced by 3,5-diethoxycarbonyl-1,4-dihydrocollidine (DDC) in vivo and in vitro. ( Atsmon, A; Epstein, O; Schoenfeld, N, 1976) |
| "Symptoms of acute porphyria have been attributed to effects of delta-aminolevulinic acid (ALA)." | 3.65 | delta-Aminolevulinic acid: influences on synaptic GABA receptor binding may explain CNS symptoms of porphyria. ( Müller, WE; Snyder, SH, 1977) |
| "A patient who had hereditary tyrosinemia was observed during two illnesses to have characteristics of acute intermittent porphyria with associated hypertension." | 3.65 | Tyrosinemia with acute intermittent porphyria: aminolevulinic acid dehydratase deficiency related to elevated urinary aminolevulinic acid levels. ( Berry, HK; Emmett, EA; Finelli, VN; Petering, HG; Strife, CF; Zuroweste, EL, 1977) |
| " These findings cast doubt on the possibility that ALA or porphobilinogen is responsible for the production of the neural manifestations of acute porphyria." | 3.65 | Prophyrin precursors in blood, urine and cerebrospinal fluid in acute porphyria. ( Percy, VA; Shanley, BC, 1977) |
| " Hexachlorobenzene porphyria in the rat provides a suitable experimental model of the stages of development of human chronic hepatic porphyria." | 3.65 | Hexachlorobenzene porphyria in rats as a model for human chronic hepatic porphyrias. ( Doss, M; Koss, G; Schermuly, E, 1976) |
| "The effects of dietary manipulations on excretion of the porphyrin precursors, delta-aminolevulinic acid (ALA), and porphobilinogen (PBG) were studied in eight patients with acute intermittent porphyria." | 3.65 | Comparative effects of glycerol and dextrose on porphyrin precursor excretion in acute intermittent porphyria. ( Bonkowsky, HL; Collins, AR; Doherty, JM; Hess, RA; Magnussen, CR; Tschudy, DP, 1976) |
| "The excretion of delta-aminolevulinic acid and porphobilinogen in the urine of 31 patients with multiple sclerosis did not differ significantly from that of 51 hospitalized control patients or eight patients with poliomyelitis." | 3.64 | PORPHOBILINOGEN AND DELTA-AMINOLEVULINIC ACID EXCRETION IN MULTIPLE SCLEROSIS. ( MARKLE, V; PAZDER, LH; TAYLOR, JD, 1965) |
| "The non-acute porphyrias are porphyria cutanea tarda, erythropoietic protoporphyria, X-linked protoporphyria, and the rare congenital erythropoietic porphyria." | 2.61 | Clinical Guide and Update on Porphyrias. ( Doss, MO; Schuppan, D; Stölzel, U, 2019) |
| "Porphyrias are a group of eight rare inherited metabolic disorders of heme biosynthesis pathway." | 2.46 | Porphyrias at a glance: diagnosis and treatment. ( Brancaleoni, V; Cappellini, MD; Di Pierro, E; Graziadei, G; Tavazzi, D, 2010) |
| "Each porphyria is described according to the enzyme in the heme biosynthetic sequence." | 2.39 | [Metabolic fate of porphyrin and its precursors in porphyria and porphyrinuria]. ( Harada, K; Kim, Y; Ohmori, S; Tomokuni, K, 1995) |
| "Porphyrias are inherited and acquired diseases of erythroid or hepatic origin, in which there are defects in specific enzymes of the heme biosynthetic pathway." | 2.38 | Free radicals involvement in neurological porphyrias and lead poisoning. ( Abdalla, DS; Bechara, EJ; Monteiro, HP, 1991) |
| "Porphyria is making increasing demands on the attention of clinicians and research worker." | 2.36 | [Hepatic porphyria]. ( Tornaghi, G; Vitali, L, 1979) |
| "The acute hepatic porphyrias (AHPs) are inherited disorders of heme biosynthesis characterized by life-threatening acute neurovisceral attacks precipitated by factors that upregulate hepatic 5-aminolevulinic acid synthase 1 (ALAS1) activity." | 1.91 | RNA interference therapy in acute hepatic porphyrias. ( Balwani, M; Keel, S; Yasuda, M, 2023) |
| "Porphyrias are caused by porphyrin accumulation resulting from defects in the heme biosynthetic pathway that typically lead to photosensitivity and possible end-stage liver disease with an increased risk of hepatocellular carcinoma." | 1.51 | Oxygen and Conformation Dependent Protein Oxidation and Aggregation by Porphyrins in Hepatocytes and Light-Exposed Cells. ( Basrur, V; Carter, EL; Herrmann, H; Lehnert, N; Maitra, D; Nesvizhskii, AI; Omary, MB; Osawa, Y; Ragsdale, SW; Richardson, R; Rittié, L; Wolf, MW; Zhang, H, 2019) |
| "Porphyria was induced in vivo in mice using 3,5-diethoxycarbonyl-1,4-dihydrocollidine or in vitro by exposing human liver Huh7 cells and keratinocytes, or their lysates, to protoporphyrin-IX, other porphyrins, or to δ-aminolevulinic acid plus deferoxamine." | 1.51 | Oxygen and Conformation Dependent Protein Oxidation and Aggregation by Porphyrins in Hepatocytes and Light-Exposed Cells. ( Basrur, V; Carter, EL; Herrmann, H; Lehnert, N; Maitra, D; Nesvizhskii, AI; Omary, MB; Osawa, Y; Ragsdale, SW; Richardson, R; Rittié, L; Wolf, MW; Zhang, H, 2019) |
| "Pretreatment with aminolevulinic acid or with protoporphyrin IX dramatically increased the light sensitivity of both TRPA1 and TRPV1 via generation of reactive oxygen species." | 1.43 | Photosensitization in Porphyrias and Photodynamic Therapy Involves TRPA1 and TRPV1. ( Babes, A; Filipovic, M; Fischer, MJ; Kichko, TI; Moparthi, L; Namer, B; Neacsu, C; Reeh, PW; Sauer, SK; Zygmunt, PM, 2016) |
| " Further characterization of the transport system for uroporphyrin in this model is expected to benefit not only our understanding of the cellular mechanism for disposal of toxic soluble wastes but also potentially the effective management of human uroporphyria and the use of uroporphyric Leishmania for vaccine/drug delivery." | 1.35 | Transgenic Leishmania model for delta-aminolevulinate-inducible monospecific uroporphyria: cytolytic phototoxicity initiated by singlet oxygen-mediated inactivation of proteins and its ablation by endosomal mobilization of cytosolic uroporphyrin. ( Chang, KP; Dutta, S; Kolli, BK; Sassa, S; Tang, A, 2008) |
| "Porphyrias are heme-associated metabolic disorders such as intermittent acute porphyria (IAP) and lead poisoning, where 5-aminolevulinate (ALA) accumulates." | 1.33 | 5-Aminolevulinate and 4, 5-dioxovalerate ions decrease GABA(A) receptor density in neuronal cells, synaptosomes and rat brain. ( Adhikari, A; Bechara, EJ; Britto, LR; Penatti, CA; Resende, RR; Ulrich, H, 2006) |
| "5-Aminolevulinic acid (ALA) is a heme precursor that accumulates in lead poisoning and inborn porphyrias." | 1.31 | DNA damage by 3,6-dihydropyrazine-2,5-dipropanoic acid, the cyclic dimerization product of 5-aminolevulinic acid. ( Di Mascio, P; Dörnemann, D; Medeiros, MH; Onuki, J; Teixeira, PC, 2001) |
| "Acute porphyrias are inherited disorders caused by partial deficiency of specific heme biosynthesis enzymes." | 1.30 | Motor neuropathy in porphobilinogen deaminase-deficient mice imitates the peripheral neuropathy of human acute porphyria. ( Baumgartner, M; Borg, J; Erne, B; Lindberg, RL; Martini, R; Meyer, UA; Ricker, K; Steck, A; Toyka, KV; Zielasek, J, 1999) |
| "Uroporphyria was produced by injecting animals with iron-dextran and giving the porphyrin precursor 5-aminolaevulinic acid in the drinking water." | 1.30 | Uroporphyria produced in mice by iron and 5-aminolaevulinic acid does not occur in Cyp1a2(-/-) null mutant mice. ( Bement, WJ; Dalton, T; Gorman, N; Nebert, DW; Sinclair, JF; Sinclair, PR; Smith, AG; Walton, HS, 1998) |
| " For groups 2 and 6, atracurium was administered at a dosage of 4 mg/kg of body weight, followed by a continuous infusion of 15 mg/kg/h." | 1.29 | Porphyrinogenic effects of atracurium, vecuronium, and pancuronium in a primed rat model. ( Bach, A; Böhrer, H; Bolsen, K; Goerz, G; Kohl, B; Martin, E; Schmidt, H, 1994) |
| "Porphyria has been associated with an increase in plasma levels of 5-aminolevulinic acid and porphobilinogen." | 1.29 | Altered 5-aminolevulinic acid metabolism leading to pseudoporphyria in hemodialysed patients. ( Del C Batlle, AM; Guolo, M; Melito, V; Parera, V; Stella, AM, 1996) |
| " at the dosage of 600-1200 mg for a variable period of 3-5 days in the first group, for 7-10 days in the patients with PCT." | 1.28 | [Evaluation of the effects of reduced glutathione in subjects with acquired and congenital changes in heme biosynthesis]. ( Alessio, L; Buizza, P; De Panfilis, G; De Vincentiis, A; Ferioli, A; Leali, C; Pasolini, G, 1992) |
| " Adjustments in dosage or route of administration were sometimes needed." | 1.28 | A gonadotropin releasing hormone analogue prevents cyclical attacks of porphyria. ( Anderson, KE; Bardin, CW; Kappas, A; Spitz, IM, 1990) |
| "Acute intermittent porphyria is a genetic disease in which endogenous hormones affect clinical expression." | 1.28 | A gonadotropin releasing hormone analogue prevents cyclical attacks of porphyria. ( Anderson, KE; Bardin, CW; Kappas, A; Spitz, IM, 1990) |
| "Catalepsy was used as a measure for psychosis and was observed after injection of serine or glycine in porphyric rats." | 1.27 | Serine and glycine-induced catalepsy in porphyric rats: an animal model for psychosis? ( Bruinvels, J; Pepplinkhuizen, L; Schouten, MJ; Wilson, JH, 1983) |
| "The porphyria is not dependent on pretreatment with iron and persists for at least 21 days after withdrawal of ALA." | 1.27 | Uroporphyria produced in mice by 20-methylcholanthrene and 5-aminolaevulinic acid. ( Bement, WJ; Elder, GH; Gorman, N; Lambrecht, RW; Roberts, AG; Sinclair, JA; Sinclair, PR; Urquhart, AJ, 1988) |
| "The porphyrias are caused by hereditary defects in the synthesis of heme." | 1.27 | The porphyrias. ( Rosen, T; Sekula, SA; Tschen, JA, 1986) |
| "Porphyria was induced in adult male Wistar rats starved for 24 hr by SC injection of 400 mg/kg allylisopropylacetamide (AIA)." | 1.27 | Endogenously formed norharman (beta-carboline) in platelet rich plasma obtained from porphyric rats. ( Bruinvels, J; Schouten, MJ, 1986) |
| "We studied one patient with major motor seizures and acute intermittent porphyria." | 1.26 | Seizure management in acute hepatic porphyria: risks of valproate and clonazepam. ( Bonkowsky, HL; Emery, S; Sinclair, JF; Sinclair, PR, 1980) |
| " After treatment with Resochin in an erroneously high dosage (1." | 1.26 | [Accident in treatment of porphyria cutanea tarda by chloroquine (Resochin) (author's transl)]. ( Eichenauer, MG; Goerz, G; Krieg, T, 1976) |
| "Clonazepam was ineffective in treating the seizures and, in high doses, seemed to exacerbate the porphyria." | 1.26 | Seizure management in acute hepatic porphyria: risks of valproate and clonazepam. ( Bonkowsky, HL; Emery, S; Sinclair, JF; Sinclair, PR, 1980) |
| "Antipyrine T1/2 was especially prolonged in patients with a history of more severe symptoms, but there was no correlation with the degree of elevation in urinary excretion of the porphyrin precursors delta-aminolevulinic acid (ALA) and porphobilinogen (PBG)." | 1.26 | Studies in porphyria. V. Drug oxidation rates in hereditary hepatic porphyria. ( Alvares, AP; Anderson, KE; Kappas, A; Sassa, S, 1976) |
| " The drug was administered at a dosage of 200 mg t." | 1.26 | Danazol administration to females with menses-associated exacerbations of acute intermittent porphyria. ( Frykholm, BC; Herrera, W; Lamon, JM; Tschudy, DP, 1979) |
| "Symptoms of acute porphyria have been attributed to effects of delta-aminolevulinic acid (ALA)." | 1.26 | delta-Aminolevulinic acid: influences on synaptic GABA receptor binding may explain CNS symptoms of porphyria. ( Müller, WE; Snyder, SH, 1977) |
| " These findings suggest that the amount of protoporphyrin IX accumulation from ALA reflects the extent of deficiency of ferrochelatase and is proportional to the dosage of abnormal EPP gene in cultured fibroblasts." | 1.26 | Accumulation of protoporphyrin IX from delta-aminolevulinic acid in bovine skin fibroblasts with hereditary erythropoietic protoporphyria. A gene-dosage effect. ( Ruth, G; Sassa, S; Schwartz, S, 1981) |
| " However, results obtained with dispersed cells in culture may not necessarily reflect the situation in vivo where the cell may have a far greater resistance to the effects of toxic agents." | 1.26 | delta-Aminolaevulinic acid uptake, toxicity, and effect on [14C]gamma-aminobutyric acid uptake into neurons and glia in culture. ( Lamm, MC; Percy, VA; Taljaard, JJ, 1981) |
| "Fibroblasts from cattle homozygous for erythropoietic protoporphyria (EPP) and with the clinical symptoms of the disease accumulated approximately sixfold greater amounts of protoporphyrin IX than cells from normal control animals." | 1.26 | Accumulation of protoporphyrin IX from delta-aminolevulinic acid in bovine skin fibroblasts with hereditary erythropoietic protoporphyria. A gene-dosage effect. ( Ruth, G; Sassa, S; Schwartz, S, 1981) |
| "Phenylbutazone T1/2s were normal in 10 porphyric patients tested." | 1.26 | Studies in porphyria. V. Drug oxidation rates in hereditary hepatic porphyria. ( Alvares, AP; Anderson, KE; Kappas, A; Sassa, S, 1976) |
| "Whereas demyelination does occur in acute porphyria where the levels of delta-aminolevulinic acid and porphobilinogen are elevated, the converse is not true; that is, demyelination is not always associated with an increase in the excretion of porphobilinogen or delta-aminolevulinic acid." | 1.24 | PORPHOBILINOGEN AND DELTA-AMINOLEVULINIC ACID EXCRETION IN MULTIPLE SCLEROSIS. ( MARKLE, V; PAZDER, LH; TAYLOR, JD, 1965) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 172 (72.27) | 18.7374 |
| 1990's | 44 (18.49) | 18.2507 |
| 2000's | 12 (5.04) | 29.6817 |
| 2010's | 8 (3.36) | 24.3611 |
| 2020's | 2 (0.84) | 2.80 |
| Authors | Studies |
|---|---|
| Yasuda, M | 1 |
| Keel, S | 1 |
| Balwani, M | 1 |
| Poli, A | 1 |
| Manceau, H | 1 |
| Nguyen, AL | 1 |
| Moulouel, B | 1 |
| Dessendier, N | 1 |
| Talbi, N | 1 |
| Puy, H | 3 |
| Junot, C | 1 |
| Gouya, L | 2 |
| Schmitt, C | 2 |
| Lefebvre, T | 2 |
| Peoc'h, K | 1 |
| Nicolas, G | 1 |
| Mirmiran, A | 1 |
| Daher, R | 1 |
| Karim, Z | 1 |
| Stölzel, U | 1 |
| Doss, MO | 5 |
| Schuppan, D | 1 |
| Maitra, D | 1 |
| Carter, EL | 1 |
| Richardson, R | 1 |
| Rittié, L | 1 |
| Basrur, V | 1 |
| Zhang, H | 1 |
| Nesvizhskii, AI | 1 |
| Osawa, Y | 1 |
| Wolf, MW | 1 |
| Ragsdale, SW | 1 |
| Lehnert, N | 1 |
| Herrmann, H | 1 |
| Omary, MB | 1 |
| Kürten, V | 1 |
| Neumann, NJ | 1 |
| Frank, J | 1 |
| Babes, A | 1 |
| Sauer, SK | 1 |
| Moparthi, L | 1 |
| Kichko, TI | 1 |
| Neacsu, C | 1 |
| Namer, B | 1 |
| Filipovic, M | 1 |
| Zygmunt, PM | 1 |
| Reeh, PW | 1 |
| Fischer, MJ | 1 |
| Nakano, K | 1 |
| Ishizuka, M | 1 |
| Sakamoto, KQ | 1 |
| Fujita, S | 1 |
| Choiniere, JR | 1 |
| Scott, CR | 1 |
| Gelb, MH | 1 |
| Turecek, F | 1 |
| Cappellini, MD | 1 |
| Brancaleoni, V | 1 |
| Graziadei, G | 1 |
| Tavazzi, D | 1 |
| Di Pierro, E | 1 |
| Gross, U | 2 |
| Meissauer, U | 1 |
| Lamoril, J | 1 |
| Deybach, JC | 3 |
| Doss, M | 13 |
| Nordmann, Y | 4 |
| WITH, TK | 2 |
| JAMES, GW | 1 |
| RUDOLPH, SG | 1 |
| ABBOTT, LD | 1 |
| SCHLENKER, FS | 1 |
| TAYLOR, NA | 1 |
| KIEHN, BP | 1 |
| TAYLOR, JD | 1 |
| PAZDER, LH | 1 |
| MARKLE, V | 1 |
| GRANICK, S | 3 |
| VANDEN SCHRIECK, HG | 1 |
| KELLERHALS, B | 1 |
| JANOUSEK, V | 1 |
| OCENASEK, M | 1 |
| KELENYI, G | 1 |
| ARATO, G | 1 |
| BUDA, V | 1 |
| ORBAN, S | 1 |
| Winkler, AS | 1 |
| Peters, TJ | 1 |
| Marsden, JT | 1 |
| Deacon, AC | 1 |
| Chandler, G | 1 |
| Macdougall, IC | 1 |
| Fukuda, H | 1 |
| Casas, A | 1 |
| Batlle, A | 1 |
| Sylantiev, C | 1 |
| Schoenfeld, N | 5 |
| Mamet, R | 4 |
| Groozman, GB | 1 |
| Drory, VE | 1 |
| Wilson, GN | 1 |
| De Matteis, F | 3 |
| Harvey, C | 2 |
| Adhikari, A | 1 |
| Penatti, CA | 2 |
| Resende, RR | 1 |
| Ulrich, H | 1 |
| Britto, LR | 1 |
| Bechara, EJ | 8 |
| Heinemann, IU | 1 |
| Jahn, M | 1 |
| Jahn, D | 1 |
| Dutta, S | 1 |
| Kolli, BK | 1 |
| Tang, A | 1 |
| Sassa, S | 11 |
| Chang, KP | 1 |
| Sima, AA | 1 |
| Kennedy, JC | 1 |
| Blakeslee, D | 1 |
| Robertson, DM | 1 |
| Silbergeld, EK | 1 |
| McColl, KE | 9 |
| Goldberg, A | 14 |
| Ibraham, NG | 1 |
| Friedland, ML | 1 |
| Levere, RD | 3 |
| Schouten, MJ | 2 |
| Bruinvels, J | 2 |
| Pepplinkhuizen, L | 1 |
| Wilson, JH | 1 |
| Laiwah, AC | 2 |
| Junor, B | 1 |
| MacPhee, GJ | 1 |
| Thompson, GG | 7 |
| Atchison, WD | 1 |
| Peterson, RE | 1 |
| Edwards, S | 1 |
| Jackson, D | 1 |
| Reynoldson, J | 1 |
| Shanley, B | 1 |
| Tishler, PV | 3 |
| Winston, SH | 2 |
| Gorchein, A | 4 |
| Knosała, P | 1 |
| Petelenz, T | 1 |
| Zuk-Popiołek, I | 1 |
| Savi, M | 1 |
| David, S | 1 |
| Dall'Aglio, P | 1 |
| te Velde, K | 1 |
| Noordhoek, KH | 1 |
| Bissell, DM | 2 |
| Bonkowsky, HL | 3 |
| Schady, W | 1 |
| Sinclair, PR | 4 |
| Emery, S | 1 |
| Sinclair, JF | 3 |
| Schwartz, S | 3 |
| Ruth, G | 1 |
| Zalar, GL | 2 |
| Poh-Fitzpatrick, MB | 2 |
| Anderson, KE | 4 |
| Kappas, A | 9 |
| Moore, MR | 15 |
| Gordon, BJ | 1 |
| Graham, DJ | 3 |
| O'Connor, LJ | 1 |
| Stewart, PM | 1 |
| Hensley, WJ | 1 |
| Bickers, DR | 2 |
| Goerz, G | 7 |
| Sick, N | 1 |
| Vizethum, W | 1 |
| Lissner, R | 2 |
| Krieg, T | 3 |
| Romeo, G | 1 |
| Day, RS | 3 |
| Eales, L | 4 |
| Disler, PB | 1 |
| Waldenström, J | 1 |
| Wallace, AM | 2 |
| Schneider, J | 3 |
| Von Tiepermann, R | 2 |
| Brandt, A | 1 |
| Magnin, PH | 1 |
| del C Batlle, AM | 2 |
| de Xifra, EA | 1 |
| Lenczner, M | 1 |
| Parera, VE | 1 |
| Stella, AM | 4 |
| Adam, C | 1 |
| Hassoun, A | 1 |
| Defresne, C | 1 |
| Guilmot-Bruneau, M | 1 |
| Wery-Follet, B | 1 |
| Saussez-De Temmerman, A | 1 |
| Westerhof, W | 1 |
| Smit, EM | 1 |
| Mustajoki, P | 4 |
| Ganda, C | 1 |
| Joshi, P | 1 |
| Kramer, S | 3 |
| Hines, JD | 1 |
| Smith, AG | 4 |
| Kostrzewska, E | 1 |
| Gregor, A | 1 |
| Lipska-Koziołowa, H | 1 |
| Traczyk, A | 1 |
| Lockwood, WH | 1 |
| Poulos, V | 1 |
| Kreimer-Birnbaum, M | 1 |
| Bannerman, RM | 1 |
| El-Khatib, M | 1 |
| Franco-Saenz, R | 1 |
| Wider de Xifra, EA | 2 |
| Batlle, AM | 3 |
| Malamud, S | 1 |
| Blekkenhorst, GH | 1 |
| Fuchs, T | 1 |
| Seubert, A | 1 |
| Seubert, S | 1 |
| Ippen, H | 2 |
| Percy, VA | 3 |
| Lamm, MC | 1 |
| Taljaard, JJ | 1 |
| Honcamp, M | 1 |
| Daume, E | 1 |
| Frank, M | 2 |
| Düsterberg, B | 1 |
| Harada, K | 1 |
| Ohmori, S | 1 |
| Kim, Y | 1 |
| Tomokuni, K | 2 |
| Kondo, M | 2 |
| Horie, Y | 2 |
| Norimoto, M | 1 |
| Tajima, F | 1 |
| Sasaki, H | 1 |
| Nanba, E | 1 |
| Kawasaki, H | 1 |
| Gullotti, D | 1 |
| Schillaci, L | 1 |
| Amato, S | 1 |
| Salerno, L | 1 |
| Böhrer, H | 1 |
| Schmidt, H | 1 |
| Bach, A | 1 |
| Martin, E | 1 |
| Kohl, B | 1 |
| Bolsen, K | 3 |
| Mevasser, R | 2 |
| Atsmon, A | 4 |
| Francis, JE | 2 |
| Badcock, NR | 1 |
| O'Reilly, DA | 1 |
| Zoanetti, GD | 1 |
| Robertson, EF | 1 |
| Parker, CJ | 1 |
| Demasi, M | 1 |
| DeLucia, R | 1 |
| Guolo, M | 1 |
| Melito, V | 1 |
| Parera, V | 1 |
| Ellefson, RD | 1 |
| Ford, RE | 1 |
| Constantin, D | 1 |
| Akhtar, RA | 1 |
| Clothier, B | 1 |
| Gorman, N | 2 |
| Dalton, T | 1 |
| Walton, HS | 1 |
| Bement, WJ | 3 |
| Nebert, DW | 1 |
| Lindberg, RL | 1 |
| Martini, R | 1 |
| Baumgartner, M | 1 |
| Erne, B | 1 |
| Borg, J | 1 |
| Zielasek, J | 1 |
| Ricker, K | 1 |
| Steck, A | 1 |
| Toyka, KV | 1 |
| Meyer, UA | 3 |
| Hift, RJ | 1 |
| Di Mascio, P | 2 |
| Teixeira, PC | 2 |
| Onuki, J | 2 |
| Medeiros, MH | 2 |
| Dörnemann, D | 2 |
| Douki, T | 1 |
| Cadet, J | 1 |
| Epstein, O | 1 |
| Petryka, ZJ | 2 |
| Lamon, JM | 2 |
| Frykholm, BC | 2 |
| Bennett, M | 1 |
| Tschudy, DP | 5 |
| Thompson, GT | 1 |
| Brugsch, J | 1 |
| Müller, H | 1 |
| Brodie, MJ | 6 |
| Stutzer, H | 1 |
| Müller, WE | 1 |
| Snyder, SH | 1 |
| Brennan, MJ | 1 |
| Cantrill, RC | 1 |
| Gidari, AS | 1 |
| Becker, DM | 1 |
| Beale, SI | 1 |
| Schwanitz, G | 1 |
| Druschky, KF | 1 |
| Schaller, KH | 1 |
| Tornaghi, G | 1 |
| Vitali, L | 1 |
| Herrera, W | 1 |
| Carlson, GP | 1 |
| Monsalve, V | 1 |
| Wolff, C | 1 |
| Gómez, R | 1 |
| Armas Merino, R | 1 |
| Canals, C | 1 |
| Hardie, RA | 1 |
| Hunter, JA | 1 |
| Wada, O | 1 |
| Marchiori, PE | 1 |
| de Assis, JL | 1 |
| Scaff, M | 1 |
| Do Serro-Azul, LG | 1 |
| Moraes, EC | 1 |
| Bacheschi, LA | 1 |
| Yassuda, N | 1 |
| Lithner, F | 1 |
| Lim, CK | 1 |
| Rideout, JM | 1 |
| Samson, DM | 1 |
| Iwanov, ED | 1 |
| Adjarov, D | 1 |
| Tsanev, R | 1 |
| Astrup, EG | 1 |
| Gray, CH | 1 |
| Sinnott, JL | 1 |
| Hofmann, C | 1 |
| Schmidt, D | 1 |
| Braun-Falco, O | 1 |
| Keogh, L | 1 |
| Rifkind, AB | 1 |
| Harber, LC | 1 |
| De Goeij, AF | 1 |
| Smit, S | 1 |
| Steveninck, JV | 1 |
| Strife, CF | 1 |
| Zuroweste, EL | 1 |
| Emmett, EA | 1 |
| Finelli, VN | 1 |
| Petering, HG | 1 |
| Berry, HK | 1 |
| Broese, I | 1 |
| Mattheus, A | 1 |
| Shanley, BC | 2 |
| Neethling, AC | 1 |
| Fischbein, A | 1 |
| Kestenbaum, D | 1 |
| Alvares, AP | 2 |
| Beal, MF | 1 |
| Atuk, NO | 1 |
| Westfall, TC | 1 |
| Turner, SM | 1 |
| Wichmann, T | 1 |
| Freye, HA | 1 |
| Houston, AB | 1 |
| Stephenson, JB | 1 |
| Peterson, A | 1 |
| Bossenmaier, I | 3 |
| Cardinal, R | 2 |
| Watson, CJ | 3 |
| Maxwell, JD | 1 |
| Kaszewska-Jablonska, I | 1 |
| Bardzik, I | 1 |
| Brzozowski, J | 1 |
| Schermuly, E | 2 |
| Koss, G | 1 |
| O'Connor, N | 1 |
| Stephenson, BD | 2 |
| Anderson, AS | 1 |
| Johnson, LW | 1 |
| Johnson, J | 1 |
| McGillion, FB | 1 |
| Frydman, RB | 1 |
| Tomaro, ML | 1 |
| Frydman, B | 1 |
| Wanschelbaum, A | 1 |
| Dhar, GJ | 1 |
| Mees, DE | 1 |
| Frederickson, EL | 1 |
| Grandchamp, B | 2 |
| Grelier, M | 1 |
| Solish, G | 1 |
| Eichenauer, MG | 2 |
| Paxton, JW | 1 |
| Beattie, AD | 1 |
| Badawy, AA | 1 |
| Evans, M | 1 |
| Hofmann, F | 1 |
| Büchner, M | 1 |
| Mühler, E | 1 |
| Magnussen, CR | 2 |
| Collins, AR | 1 |
| Doherty, JM | 2 |
| Hess, RA | 1 |
| Goujon, R | 1 |
| Philibert, E | 1 |
| Bernard, P | 1 |
| Normand, J | 1 |
| Boucherat, M | 1 |
| Isenschmid, M | 1 |
| König, C | 1 |
| Fässli, C | 1 |
| Haenel, A | 1 |
| Hänggi, W | 1 |
| Schneider, H | 1 |
| Marty, H | 1 |
| Brady, AM | 1 |
| Lock, EA | 1 |
| Pereira, B | 1 |
| Curi, R | 1 |
| Kokubun, E | 1 |
| Thunell, S | 3 |
| Floderus, Y | 1 |
| Henrichson, A | 1 |
| Meissner, P | 1 |
| Sinclair, J | 1 |
| Kauppinen, R | 1 |
| Lannfelt, L | 1 |
| Lilius, L | 1 |
| Koistinen, J | 1 |
| Ferioli, A | 1 |
| De Vincentiis, A | 1 |
| Buizza, P | 1 |
| Pasolini, G | 1 |
| Leali, C | 1 |
| De Panfilis, G | 1 |
| Alessio, L | 1 |
| Arena, A | 1 |
| Russo, P | 1 |
| Scuderi, D | 1 |
| Timonen, K | 1 |
| Seppäläinen, AM | 1 |
| Matikainen, E | 1 |
| Tenhunen, R | 2 |
| Wainstok de Calmanovici, R | 1 |
| Cochón, AC | 1 |
| Zenklusen, JC | 1 |
| Aldonatti, C | 2 |
| Cabral, JR | 1 |
| San Martín de Viale, LC | 2 |
| Bonkovsky, HL | 1 |
| Healey, JF | 1 |
| Lourie, AN | 1 |
| Gerron, GG | 1 |
| Sieg, I | 1 |
| Beckh, K | 1 |
| Kersten, U | 1 |
| Monteiro, HP | 3 |
| Abdalla, DS | 3 |
| Hermes-Lima, M | 1 |
| Valle, VG | 1 |
| Vercesi, AE | 1 |
| Deam, S | 1 |
| Elder, GH | 3 |
| Plewinska, M | 1 |
| Holmberg, L | 2 |
| Wetmur, JG | 1 |
| Desnick, RJ | 1 |
| Herrick, AL | 2 |
| Spitz, IM | 1 |
| Bardin, CW | 1 |
| Beukeveld, GJ | 1 |
| Wolthers, BG | 1 |
| Wadman, SK | 1 |
| Amram, D | 1 |
| Phung, LN | 1 |
| Lesbros, D | 1 |
| Smith, SG | 1 |
| Smyth, SJ | 1 |
| Hift, R | 1 |
| Sohnius, U | 1 |
| Meissner, PN | 1 |
| Vila, MC | 1 |
| Adamson, AR | 1 |
| Augusto, O | 1 |
| Lambrecht, RW | 2 |
| Jacobs, JM | 1 |
| Fujishiro, K | 1 |
| Inoue, N | 1 |
| Mori, K | 1 |
| Ikeda, M | 1 |
| Hori, H | 1 |
| Lurie, Y | 1 |
| Green, P | 1 |
| Bomstein, Y | 1 |
| Hannan, CJ | 1 |
| Kettler, T | 1 |
| Dabe, I | 1 |
| Clark, T | 1 |
| Faljoni-Alàrio, A | 1 |
| Miranda, CL | 1 |
| Henderson, MC | 1 |
| Wang, JL | 1 |
| Nakaue, HS | 1 |
| Buhler, DR | 1 |
| Seki, Y | 1 |
| Kawanishi, S | 1 |
| Sano, S | 1 |
| Reed, C | 1 |
| Hempenius, R | 1 |
| Urquhart, AJ | 1 |
| Roberts, AG | 1 |
| Sinclair, JA | 1 |
| Yeung Laiwah, AC | 1 |
| Webber, R | 2 |
| Burnett, D | 1 |
| Goudie, JH | 1 |
| Yeung-Laiwah, AA | 1 |
| Wehmeier, A | 1 |
| Fischer, JT | 1 |
| Schneider, W | 1 |
| Sekula, SA | 1 |
| Tschen, JA | 1 |
| Rosen, T | 1 |
| Lundgren, J | 1 |
| Birnie, GG | 1 |
| Chan, KM | 1 |
| Ladenson, JH | 1 |
| Vaidya, HC | 1 |
| Kanan, R | 1 |
| Udagawa, M | 1 |
| Hirayama, C | 1 |
| Olmos, S | 1 |
| Abuaud Abo-Mohor, MC | 1 |
| Liberman, C | 1 |
| Merk, H | 1 |
| Kaada, B | 1 |
| Romslo, I | 1 |
| Sixel-Dietrich, F | 2 |
| Verspohl, F | 2 |
| Schiller, A | 1 |
| Desaga, U | 1 |
| Leonhardt, KF | 1 |
| Frahm, H | 1 |
| Siepker, LJ | 1 |
| Zakhariia, EA | 1 |
| Temnik, IV | 1 |
| Romanishin, IaN | 1 |
| Oey, PL | 1 |
| Fleury, P | 1 |
| Hische, EA | 1 |
| Zuyderhoudt, FM | 1 |
| Zawirska, B | 1 |
| Kwiatkowska, W | 1 |
| Nowojska, A | 1 |
| Simon, N | 1 |
| Siklósi, C | 1 |
| Schmid, R | 1 |
| Piper, WN | 1 |
| Tephly, TR | 1 |
| Pfändler, U | 1 |
| Levine, JB | 1 |
| Cheesman, JO | 1 |
| Torkington, P | 1 |
| Bhalla, KK | 1 |
| Levin, EY | 1 |
| Sarkar, D | 1 |
| Cardinal, RA | 1 |
| Weimer, M | 1 |
| Swaim, WR | 1 |
| Berk, PD | 1 |
| Bradlow, HL | 1 |
35 reviews available for aminolevulinic acid and Porphyrias
| Article | Year |
|---|---|
Regulation and tissue-specific expression of δ-aminolevulinic acid synthases in non-syndromic sideroblastic anemias and porphyrias.
Topics: 5-Aminolevulinate Synthetase; Aminolevulinic Acid; Anemia, Sideroblastic; Animals; Binding Sites; GA | 2019 |
Clinical Guide and Update on Porphyrias.
Topics: Aminolevulinic Acid; Gastroenterology; Gastrointestinal Diseases; Humans; Nervous System Diseases; P | 2019 |
[Diagnosis of the porphyrias : From A (as in aminolevulinic acid) to Z (as in zinc protoporphyrin)].
Topics: Aminolevulinic Acid; Biomarkers; Diagnosis, Differential; Porphyrias; Protoporphyrins; Reproducibili | 2016 |
Porphyrias at a glance: diagnosis and treatment.
Topics: Acute Disease; Aminolevulinic Acid; Chronic Disease; Genetic Testing; Heme; Humans; Porphobilinogen; | 2010 |
Aminolevulinic acid: from its unique biological function to its star role in photodynamic therapy.
Topics: Aminolevulinic Acid; Animals; Diagnostic Imaging; Humans; Neoplasms; Oxygen; Pest Control; Photochem | 2005 |
The biochemistry of heme biosynthesis.
Topics: Aminolevulinic Acid; Archaea; Bacteria; Heme; Herbicides; Models, Molecular; Neoplasms; Photochemoth | 2008 |
Heme metabolism in erythroid and hepatic cells.
Topics: 5-Aminolevulinate Synthetase; Aminolevulinic Acid; Coproporphyrinogen Oxidase; Erythrocytes; Erythro | 1983 |
Laboratory evaluation in porphyria.
Topics: Acute Disease; Aminolevulinic Acid; Animals; Carrier State; Chemistry, Clinical; Diagnosis, Differen | 1982 |
Neurologic manifestations of acute porphyria.
Topics: Acute Disease; Aminolevulinic Acid; Animals; Central Nervous System; Depression; Electrophysiology; | 1982 |
A short history of porphyrins and the porphyrias.
Topics: Aminolevulinic Acid; Animals; Cattle; Europe; History, 19th Century; History, 20th Century; Humans; | 1980 |
The hepatic porphyrias.
Topics: 5-Aminolevulinate Synthetase; Acute Disease; Adolescent; Adult; Aminolevulinic Acid; Chemical Phenom | 1980 |
Genetic, metabolic, and biochemical aspects of the porphyrias.
Topics: Aminolevulinic Acid; Animals; Cat Diseases; Cats; Cattle; Cattle Diseases; Erythrocytes; Heme; Human | 1981 |
Porphyrias and the kidney.
Topics: 5-Aminolevulinate Synthetase; Aminolevulinic Acid; Animals; Coproporphyrinogens; Coproporphyrins; He | 1981 |
The porphyrias--a review.
Topics: Acute Disease; Aged; Alcoholism; Aminolevulinic Acid; Feces; Female; Heme; Humans; Iron; Liver Disea | 1981 |
[Metabolic fate of porphyrin and its precursors in porphyria and porphyrinuria].
Topics: Aminolevulinic Acid; Animals; Heme; Humans; Porphyrias; Porphyrins; Protoporphyrins | 1995 |
[Methods of determination of porphyrins and their precursors--introduction of analytical methods for porphyrin metabolites].
Topics: Aminolevulinic Acid; Chromatography; Chromatography, Thin Layer; Electrophoresis; Humans; Porphobili | 1995 |
[Porphyrins in urine, blood, and feces and delta-aminolevulinic acid and porphobilinogen].
Topics: Aminolevulinic Acid; Chromatography, High Pressure Liquid; Diagnosis, Differential; Feces; Humans; P | 1995 |
[Delta-Aminolevulinic acid in urine (screening method)].
Topics: Aminolevulinic Acid; Chromatography, High Pressure Liquid; Colorimetry; Fluorometry; Humans; Porphyr | 1995 |
Porphyrins, porphyrias, cancer and photodynamic therapy--a model for carcinogenesis.
Topics: Aminolevulinic Acid; Heme; Humans; Models, Biological; Neoplasms; Photochemotherapy; Porphyrias; Por | 1993 |
The porphyrias [corrected]: characteristics and laboratory tests.
Topics: Aminolevulinic Acid; Environmental Exposure; Feces; Humans; Porphobilinogen; Porphyrias; Porphyrins | 1996 |
Oxidative stress in acute intermittent porphyria and lead poisoning may be triggered by 5-aminolevulinic acid.
Topics: Aminolevulinic Acid; Animals; Calcium; DNA Damage; Heme; Humans; Iron; Lead Poisoning; Lipid Peroxid | 1996 |
Enzymatic formation and cellular regulation of heme synthesis.
Topics: 5-Aminolevulinate Synthetase; Aminolevulinic Acid; Animals; Coenzyme A; Coproporphyrinogens; Enzyme | 1977 |
The neurological manifestations of porphyria: a review.
Topics: Acute Disease; Aminolevulinic Acid; Animals; Heme; Humans; Liver; Liver Diseases; Nervous System; Ne | 1977 |
[Pathobiochemistry of porphyrias].
Topics: Acute Disease; Aminolevulinic Acid; Catalase; Chronic Disease; Cytochrome P-450 Enzyme System; Heme; | 1977 |
Hemes, chlorophylls, and related compounds: biosynthesis and metabolic regulation.
Topics: 5-Aminolevulinate Synthetase; Aminolevulinic Acid; Animals; Bacteria; Chlorophyll; Fungi; Heme; Hemi | 1978 |
[Chromosome studies in patients with intermittent porphyria].
Topics: Adult; Aminolevulinic Acid; Chromosome Aberrations; Female; Heme; Humans; Hydroxymethylbilane Syntha | 1979 |
[Hepatic porphyria].
Topics: Aminolevulinic Acid; Humans; Liver; Liver Diseases; Porphyrias; Porphyrins | 1979 |
Haematological disturbances of porphyrin metabolism.
Topics: Adult; Aged; Aminolevulinic Acid; Erythropoiesis; Female; Humans; Lead Poisoning; Liver; Liver Disea | 1979 |
The laboratory investigation of the porphyrin disorders: a review.
Topics: Aminolevulinic Acid; Erythropoiesis; Feces; Heme; Humans; Lead Poisoning; Liver; Molecular Conformat | 1976 |
[Porphyria variegata (author's transl)].
Topics: Adult; Aminolevulinic Acid; Coproporphyrins; Erythrocytes; Feces; Female; Hand; Humans; Lip; Porphob | 1975 |
Free radicals involvement in neurological porphyrias and lead poisoning.
Topics: Aminolevulinic Acid; Animals; Erythrocytes; Free Radicals; Glutathione Peroxidase; Humans; Lead Pois | 1991 |
Laboratory investigation of the porphyrias.
Topics: Aminolevulinic Acid; Clinical Laboratory Techniques; Humans; Porphyrias; Porphyrinogens | 1990 |
Pathogenesis of acute porphyria.
Topics: Acute Disease; Aminolevulinic Acid; Animals; Heme; Humans; Nervous System; Porphobilinogen; Porphyri | 1987 |
Intermittent acute porphyria: the enzymatic defect.
Topics: 5-Aminolevulinate Synthetase; Adenosine Triphosphatases; Alanine; Aminolevulinic Acid; Ammonia-Lyase | 1974 |
Endocrine-gene interaction in the pathogenesis of acute intermittent porphyria.
Topics: 5-Aminolevulinate Synthetase; Aminolevulinic Acid; Ammonia-Lyases; Androstenedione; Animals; Biotran | 1974 |
1 trial available for aminolevulinic acid and Porphyrias
| Article | Year |
|---|---|
Erythropoietin treatment in the neuropsychiatric porphyrias.
Topics: Adult; Aged; Aminolevulinic Acid; Erythropoietin; Female; Hematologic Tests; Hemoglobins; Humans; Ma | 2003 |
202 other studies available for aminolevulinic acid and Porphyrias
| Article | Year |
|---|---|
RNA interference therapy in acute hepatic porphyrias.
Topics: Aminolevulinic Acid; Heme; Humans; Pain; Porphyrias; Porphyrias, Hepatic; Quality of Life; RNA Inter | 2023 |
Quantification of Urine and Plasma Porphyrin Precursors Using LC-MS in Acute Hepatic Porphyrias: Improvement in Routine Diagnosis and in the Monitoring of Kidney Failure Patients.
Topics: Aminolevulinic Acid; Chromatography, Liquid; Humans; Porphobilinogen; Porphyrias; Porphyrias, Hepati | 2023 |
Oxygen and Conformation Dependent Protein Oxidation and Aggregation by Porphyrins in Hepatocytes and Light-Exposed Cells.
Topics: Aminolevulinic Acid; Animals; Carcinoma, Hepatocellular; Cell Line; Deferoxamine; Heme; Hepatocytes; | 2019 |
Photosensitization in Porphyrias and Photodynamic Therapy Involves TRPA1 and TRPV1.
Topics: Aminolevulinic Acid; Animals; Cells, Cultured; HEK293 Cells; Humans; Mice; Mice, Inbred C57BL; Neuro | 2016 |
Absolute requirement for iron in the development of chemically induced uroporphyria in mice treated with 3-methylcholanthrene and 5-aminolevulinate.
Topics: Aminolevulinic Acid; Animals; Cytochrome P-450 CYP1A2; Iron; Male; Methylcholanthrene; Mice; Mice, I | 2009 |
Direct assay of delta-aminolevulinic acid dehydratase in heme biosynthesis for the detection of porphyrias by tandem mass spectrometry.
Topics: Aminolevulinic Acid; Deuterium; Erythrocytes; Heme; Humans; Kinetics; Porphobilinogen; Porphobilinog | 2010 |
[The laboratory diagnostics of disorders of porphyrin metabolism: a lecture].
Topics: Aminolevulinic Acid; Heme; Humans; Porphyrias; Porphyrins | 2012 |
A molecular, enzymatic and clinical study in a family with hereditary coproporphyria.
Topics: Adult; Aminolevulinic Acid; Arginine; Coproporphyrinogen Oxidase; DNA Mutational Analysis; Feces; Fe | 2002 |
Excretion of porphobilinogen and Delta-aminolaevulinic acid in acute porphyria.
Topics: Amino Acids; Aminolevulinic Acid; Biological Products; Humans; Pigments, Biological; Porphobilinogen | 1961 |
Delta-amino-levulinic acid, porphobilinogen, and porphyrin excretion throughout pregnancy in a patient with acute intermittent porphyria with "passive porphyria" in the infant.
Topics: Amino Acids; Aminolevulinic Acid; Female; Humans; Infant, Newborn, Diseases; Porphobilinogen; Porphy | 1961 |
THE CHROMATOGRAPHIC SEPARATION, DETERMINATION, AND DAILY EXCRETION OF URINARY PORPHOBILINOGEN, AMINO ACETONE, AND DELTA-AMINOLEVULINIC ACID.
Topics: Acetone; Aminolevulinic Acid; Anemia; Anemia, Sickle Cell; Chromatography; Fluids and Secretions; Ho | 1964 |
PORPHOBILINOGEN AND DELTA-AMINOLEVULINIC ACID EXCRETION IN MULTIPLE SCLEROSIS.
Topics: Amino Acids; Aminolevulinic Acid; Demyelinating Diseases; Diagnosis, Differential; Fluids and Secret | 1965 |
Porphobilinogen and delta-amino levulinic acid in acute porphyria.
Topics: Aminolevulinic Acid; Humans; Keto Acids; Ketones; Porphobilinogen; Porphyria, Acute Intermittent; Po | 1955 |
[Studies on the activity of 5-aminolevulinic acid dehydrase in the blood in experimental porphyria and in patients].
Topics: Aminolevulinic Acid; Humans; Hydro-Lyases; Oxidoreductases; Porphyrias | 1960 |
[Excretion of delta-aminolevulinic acid and porphobilinogen in experimental porphyria in rabbits].
Topics: Amino Acids; Aminolevulinic Acid; Animals; Humans; Porphobilinogen; Porphyrias; Rabbits | 1960 |
[On the excretion of 5-aminolevulinic acid and porphobilinogen in latent porphyria].
Topics: Amino Acids; Aminolevulinic Acid; Humans; Porphobilinogen; Porphyrias; Porphyrins; Pyrroles | 1961 |
Acute neuropathy mimicking porphyria induced by aminolevulinic acid during photodynamic therapy.
Topics: Acute Disease; Aged; Aged, 80 and over; Aminolevulinic Acid; Barrett Esophagus; Diagnosis, Different | 2005 |
Tales from the neural genome: the lessons of homozygous porphyria.
Topics: Acute Disease; Aminolevulinic Acid; Humans; Mental Disorders; Porphyrias; Proteomics | 2004 |
Inducing coproporphyria in rat hepatocyte cultures using cyclic AMP and cyclic AMP-releasing agents.
Topics: Aminolevulinic Acid; Animals; Cells, Cultured; Coproporphyrinogen Oxidase; Coproporphyrins; Cyclic A | 2005 |
5-Aminolevulinate and 4, 5-dioxovalerate ions decrease GABA(A) receptor density in neuronal cells, synaptosomes and rat brain.
Topics: Aminolevulinic Acid; Animals; Brain; Cell Line; Cell Survival; Humans; Immunohistochemistry; Ions; M | 2006 |
Transgenic Leishmania model for delta-aminolevulinate-inducible monospecific uroporphyria: cytolytic phototoxicity initiated by singlet oxygen-mediated inactivation of proteins and its ablation by endosomal mobilization of cytosolic uroporphyrin.
Topics: Aminolevulinic Acid; Animals; Animals, Genetically Modified; Azides; Biological Transport; Cell Memb | 2008 |
Experimental porphyric neuropathy: a preliminary report.
Topics: Aminolevulinic Acid; Animals; Dose-Response Relationship, Drug; Hematoporphyrins; Levulinic Acids; M | 1981 |
Indirectly acting neurotoxins.
Topics: Aminolevulinic Acid; Animals; Brain; Dopamine; Estradiol; Female; gamma-Aminobutyric Acid; Lead Pois | 1983 |
The biochemical basis of the acute porphyrias.
Topics: Acute Disease; Aminolevulinic Acid; Heme; Humans; Nervous System Diseases; Porphyrias; Porphyrins | 1983 |
Serine and glycine-induced catalepsy in porphyric rats: an animal model for psychosis?
Topics: Allylisopropylacetamide; Aminolevulinic Acid; Animals; Catalepsy; Disease Models, Animal; Glycine; H | 1983 |
Charcoal haemoperfusion and haemodialysis in acute intermittent porphyria.
Topics: Acute Disease; Adult; Aminolevulinic Acid; Charcoal; Female; Hemoperfusion; Humans; Porphobilinogen; | 1983 |
Excretion of porphyrins and porphyrin precursors during neuromuscular paralysis produced by dithiobiuret.
Topics: Aminolevulinic Acid; Animals; Disease Models, Animal; Levulinic Acids; Male; Muscle Hypotonia; Neuro | 1984 |
Neuropharmacology of delta-aminolaevulinic acid. II. Effect of chronic administration in mice.
Topics: Aminolevulinic Acid; Animals; Behavior, Animal; Disease Models, Animal; Levulinic Acids; Male; Mice; | 1984 |
Sorbent therapy of the porphyrias. III. Comparative efficacy of experimental plasma perfusion with several commercial hemoperfusion cartridges.
Topics: Aminolevulinic Acid; Charcoal; Hemoperfusion; Humans; Porphobilinogen; Porphyrias | 1984 |
Determination of delta-aminolaevulinic acid in biological fluids by gas-liquid chromatography with electron-capture detection.
Topics: Aminocaproic Acid; Aminolevulinic Acid; Body Fluids; Chromatography, Gas; Chromatography, Thin Layer | 1984 |
[A case of acute hepatic porphyria].
Topics: Acute Disease; Adult; Aminolevulinic Acid; Coproporphyrins; Humans; Liver Diseases; Male; Porphobili | 1983 |
[Clinical heterogeneity of hereditary coproporphyria: diagnostic usefulness of biochemical studies. Study of a familial case].
Topics: Aminolevulinic Acid; Coproporphyrins; Female; Humans; Middle Aged; Pedigree; Porphobilinogen; Porphy | 1983 |
[Hereditary coproporphyria in 2 Dutch families].
Topics: Adult; Aged; Aminolevulinic Acid; Coproporphyrins; Feces; Female; Humans; Male; Middle Aged; Pedigre | 1984 |
Simple screening test for qualitative detection of increased delta-aminolevulinic acid in urine.
Topics: Acute Disease; Aminolevulinic Acid; Benzaldehydes; Colorimetry; Humans; Levulinic Acids; Porphobilin | 1984 |
Seizure management in acute hepatic porphyria: risks of valproate and clonazepam.
Topics: 5-Aminolevulinate Synthetase; Adult; Aminolevulinic Acid; Animals; Benzodiazepinones; Chick Embryo; | 1980 |
Accumulation of protoporphyrin IX from delta-aminolevulinic acid in bovine skin fibroblasts with hereditary erythropoietic protoporphyria. A gene-dosage effect.
Topics: Aminolevulinic Acid; Animals; Cattle; Edetic Acid; Erythropoiesis; Fibroblasts; Iron; Levulinic Acid | 1981 |
Studies in porphyria: functional evidence for a partial deficiency of ferrochelatase activity in mitogen-stimulated lymphocytes from patients with erythropoietic protoporphyria.
Topics: Adolescent; Adult; Aminolevulinic Acid; Cells, Cultured; Child; Edetic Acid; Female; Genetic Carrier | 1982 |
Pathogenesis and treatment of acute intermittent porphyria: discussion paper.
Topics: Acute Disease; Aminolevulinic Acid; Blood-Brain Barrier; Heme; Humans; Liver Diseases; Porphobilinog | 1983 |
Sorbent therapy of the porphyrias. II. Experimental plasma or hemoperfusion with a commercial charcoal cartridge.
Topics: Adsorption; Aminolevulinic Acid; Charcoal; Evaluation Studies as Topic; Hemin; Hemoperfusion; Humans | 1983 |
Monopyrroles in porphyria, psychosis and lead exposure.
Topics: 5-Aminolevulinate Synthetase; Acute Disease; Aminolevulinic Acid; Animals; Heme Oxygenase (Decyclizi | 1980 |
Acute intermittent porphyria.
Topics: Acute Disease; Adult; Aminolevulinic Acid; Female; Humans; Male; Porphobilinogen; Porphyrias; Seizur | 1981 |
An acute attack of variegate porphyria complicated by severe autonomic neuropathy.
Topics: Acute Disease; Adult; Aminolevulinic Acid; Autonomic Nervous System Diseases; Female; Humans; Porpho | 1981 |
Environmental and drug factors in hepatic porphyria.
Topics: 5-Aminolevulinate Synthetase; Allyl Compounds; Aminolevulinic Acid; Barbiturates; Chemical and Drug | 1982 |
[Influence of p-amino-benzoic acid on the hexachlorobenzene induced porphyria in the rat (author's transl)].
Topics: 4-Aminobenzoic Acid; Aminobenzoates; Aminolevulinic Acid; Animals; Chlorobenzenes; Cytochrome P-450 | 1980 |
Alterations in haem biosynthesis during the human menstrual cycle: studies in normal subjects and patients with latent and active acute intermittent porphyria.
Topics: 5-Aminolevulinate Synthetase; Adrenal Cortex Hormones; Adult; Aminolevulinic Acid; Erythrocytes; Fem | 1982 |
Acute intermittent porphyria.
Topics: Acute Disease; Aminolevulinic Acid; Humans; Levulinic Acids; Liver Diseases; Porphobilinogen; Porphy | 1982 |
New type of acute porphyria with porphobilinogen synthase (delta-aminolevulinic acid dehydratase) defect in the homozygous state.
Topics: Adult; Aminolevulinic Acid; Dithiothreitol; Enzyme Activation; Homozygote; Humans; Lead Poisoning; L | 1982 |
Acquired and inherited porphyria: clinical and biochemical features.
Topics: Aminolevulinic Acid; Chromatography, Thin Layer; Erythrocytes; Female; Humans; Male; Pedigree; Porph | 1982 |
Intermittent acute porphyria.
Topics: Acute Disease; Adult; Aminolevulinic Acid; Female; Humans; Porphobilinogen; Porphyrias; Porphyrins | 1982 |
[Hemin treatment in a case of porphyria variegata].
Topics: Adult; Aminolevulinic Acid; Coproporphyrins; Female; Heme; Hemin; Humans; Liver Diseases; Porphobili | 1982 |
[Variegate porphyria; a family study].
Topics: Adult; Aminolevulinic Acid; Female; Humans; Male; Middle Aged; Pedigree; Porphobilinogen; Porphyrias | 1981 |
Normal erythrocyte uroporphyrinogen I synthase in a kindred with acute intermittent porphyria.
Topics: Aminolevulinic Acid; Ammonia-Lyases; Erythrocytes; Feces; Finland; Humans; Hydroxymethylbilane Synth | 1981 |
Acute intermittent porphyria. A case report.
Topics: Acute Disease; Adult; Aminolevulinic Acid; Coproporphyrins; Feces; Female; Humans; Male; Porphobilin | 1981 |
Effects of alcohol on inborn errors of metabolism: porphyria cutanea tarda and hemochromatosis.
Topics: Alcoholism; Aminolevulinic Acid; Coproporphyrins; Ethanol; Hemochromatosis; Hemosiderosis; Humans; I | 1980 |
Drugs and the hepatic porphyrias.
Topics: Acetamides; Aminolevulinic Acid; Animals; Barbiturates; Cats; Dicarbethoxydihydrocollidine; Dogs; Gr | 1980 |
[Porphyria variegata in Poland. Diagnosis and differentiation].
Topics: Adolescent; Adult; Aminolevulinic Acid; Child; Diagnosis, Differential; Feces; Female; Humans; Male; | 1980 |
A clinical porphyrin unit: four years' experience.
Topics: Aminolevulinic Acid; Australia; Hospital Units; Humans; Porphobilinogen; Porphyrias; Porphyrins; Ref | 1980 |
Afro-Americans and acute intermittent porphyria (AIP).
Topics: Acute Disease; Adolescent; Adult; Africa; Aminolevulinic Acid; Black People; Child; Child, Preschool | 1980 |
Acute intermittent porphyria--another approach to therapy.
Topics: 5-Aminolevulinate Synthetase; Acute Disease; Adult; Aminolevulinic Acid; Ammonia-Lyases; Female; Fol | 1980 |
Acute hepatic porphyria syndrome with porphobilinogen synthase defect.
Topics: Acute Disease; Adult; Amino Acids; Aminolevulinic Acid; Erythrocytes; Feces; Female; Humans; Lead; L | 1980 |
The clinical and biochemical features of variegate porphyria: an analysis of 300 cases studied at Groote Schuur Hospital, Cape Town.
Topics: Adult; Aminolevulinic Acid; Diagnosis, Differential; Female; Humans; Male; Porphyrias; Porphyrins; R | 1980 |
Anticonvulsant-induced unclassified porphyria.
Topics: Adult; Aminolevulinic Acid; Anticonvulsants; Diagnosis, Differential; Epilepsy; Humans; Male; Phenob | 1980 |
delta-Aminolaevulinic acid uptake, toxicity, and effect on [14C]gamma-aminobutyric acid uptake into neurons and glia in culture.
Topics: Aminolevulinic Acid; Animals; Brain; Cells, Cultured; Chick Embryo; Dinitrophenols; gamma-Aminobutyr | 1981 |
Hormonal oral contraceptives, urinary porphyrin excretion and porphyrias.
Topics: Adult; Aminolevulinic Acid; Contraceptives, Oral, Combined; Contraceptives, Oral, Hormonal; Copropor | 1995 |
Clinical usefulness of cimetidine treatment for acute relapse in intermittent porphyria.
Topics: Acute Disease; Adult; Aminolevulinic Acid; Blood Glucose; Cimetidine; Coproporphyrins; Feces; Humans | 1995 |
[Clinical and laboratory findings concerning at first dietary and afterwards cimetidine treatment of acute intermittent porphyria].
Topics: Acute Disease; Adult; Aminolevulinic Acid; Cimetidine; Coproporphyrins; Female; Humans; Middle Aged; | 1994 |
Porphyrinogenic effects of atracurium, vecuronium, and pancuronium in a primed rat model.
Topics: 5-Aminolevulinate Synthetase; Aminolevulinic Acid; Animals; Atracurium; Liver; Male; Pancuronium; Po | 1994 |
[Porphyria and porphyrinuria].
Topics: Aminolevulinic Acid; Diagnosis, Differential; Humans; Porphobilinogen; Porphyrias; Porphyrins; Retro | 1993 |
Genetic variation of iron-induced uroporphyria in mice.
Topics: Aminolevulinic Acid; Animals; Drug Tolerance; Hydrocarbons; Iron; Liver; Mice; Mice, Hairless; Mice, | 1993 |
Childhood porphyrias: implications and treatments.
Topics: Adolescent; Aged; Aminolevulinic Acid; Child; Child, Preschool; Coproporphyrinogen Oxidase; Female; | 1993 |
The prooxidant effect of 5-aminolevulinic acid in the brain tissue of rats: implications in neuropsychiatric manifestations in porphyrias.
Topics: Aminolevulinic Acid; Animals; Biological Transport; Brain; Calcium; Catalase; Cerebral Cortex; Ferri | 1996 |
Altered 5-aminolevulinic acid metabolism leading to pseudoporphyria in hemodialysed patients.
Topics: Acute Disease; Adult; Aged; Aminolevulinic Acid; Case-Control Studies; Female; Hot Temperature; Huma | 1996 |
Uroporphyria induced by 5-aminolaevulinic acid alone in Ahrd SWR mice.
Topics: Aminolevulinic Acid; Animals; Cytochrome P-450 Enzyme System; Genotype; Iron Overload; Liver; Male; | 1996 |
Uroporphyria produced in mice by iron and 5-aminolaevulinic acid does not occur in Cyp1a2(-/-) null mutant mice.
Topics: Aminolevulinic Acid; Animals; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP1A2; Cytochrome P-450 Enz | 1998 |
Motor neuropathy in porphobilinogen deaminase-deficient mice imitates the peripheral neuropathy of human acute porphyria.
Topics: Acute Disease; Aminolevulinic Acid; Animals; Disease Models, Animal; Electrophysiology; Femoral Nerv | 1999 |
The diagnosis of porphyria.
Topics: Aminolevulinic Acid; Female; Genetic Techniques; Genetic Testing; Heme; Humans; Mutation; Porphobili | 1999 |
DNA damage by 5-aminolevulinic and 4,5-dioxovaleric acids in the presence of ferritin.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Aminolevulinic Acid; Deoxyguanosine; DNA Adducts; DNA Damage; Ferritins | 2000 |
DNA damage by 3,6-dihydropyrazine-2,5-dipropanoic acid, the cyclic dimerization product of 5-aminolevulinic acid.
Topics: Aminolevulinic Acid; Copper; Cyclization; Deoxyguanosine; Dimerization; DNA Damage; Oxidation-Reduct | 2001 |
The effect of beta-adrenergic blocking agents on experimental porphyria induced by 3,5-diethoxycarbonyl-1,4-dihydrocollidine (DDC) in vivo and in vitro.
Topics: 5-Aminolevulinate Synthetase; Adrenergic beta-Antagonists; Aminolevulinic Acid; Animals; Chick Embry | 1976 |
A simple method for measuring erythrocyte porphobilinogenase, and its use in the diagnosis of acute intermittent porphyria.
Topics: Aminolevulinic Acid; Ammonia-Lyases; Erythrocytes; Hemolysis; Humans; Hydrogen-Ion Concentration; Po | 1978 |
Enzyme abnormalities in the porphyrias.
Topics: Acute Disease; Aminolevulinic Acid; Chronic Disease; Humans; Hydroxymethylbilane Synthase; Porphyria | 1977 |
Prevention of acute porphyric attacks by intravenous haematin.
Topics: Acute Disease; Adult; Aminolevulinic Acid; Blood Pressure; Circadian Rhythm; Drug Evaluation; Female | 1978 |
Haematin therapy and leucocyte delta-aminolevulinic-acid-synthase activity in prolonged attack of acute porphyria.
Topics: 5-Aminolevulinate Synthetase; Acute Disease; Adult; Aminolevulinic Acid; Drug Administration Schedul | 1979 |
[Urinary excretion of porphyrins and their precursors. Longterm observations in acute intermittent porphyrias (author's transl)].
Topics: Aminolevulinic Acid; Coproporphyrins; Estrogens; Humans; Porphobilinogen; Porphyrias; Porphyrins; Ur | 1979 |
Quantitation of 3-ethyl-5-hydroxy-4,5-dimethyl-delta 3-pyrrolin-2-one in the urine of patients with acute intermittent porphyria.
Topics: Acute Disease; Adult; Aminolevulinic Acid; Chromatography, Gas; Female; Heme; Humans; Porphobilinoge | 1979 |
[Letter: Comments and conclusion to H. Stutzer: Typical and atypical roentgen pictures in the acute porphyria. Fortschr. Röntgenstr. 123,6 (1975) 588-590].
Topics: Abdomen, Acute; Acute Disease; Aminolevulinic Acid; Diagnosis, Differential; Female; Humans; Middle | 1976 |
delta-Aminolevulinic acid: influences on synaptic GABA receptor binding may explain CNS symptoms of porphyria.
Topics: Aminolevulinic Acid; Animals; Anura; Binding, Competitive; Brain; Dose-Response Relationship, Drug; | 1977 |
Delta-aminolaevulinic acid is a potent agonist for GABA autoreceptors.
Topics: Aminolevulinic Acid; Animals; Bicuculline; gamma-Aminobutyric Acid; Levulinic Acids; Male; Picrotoxi | 1979 |
Danazol administration to females with menses-associated exacerbations of acute intermittent porphyria.
Topics: Adult; Aminolevulinic Acid; Danazol; Female; Hemin; Humans; Menstruation; Porphobilinogen; Porphyria | 1979 |
Brominated benzene induction of hepatic porphyria.
Topics: Aminolevulinic Acid; Animals; Bromobenzenes; Female; Liver; Porphyrias; Porphyrins; Rats; Structure- | 1979 |
[Effect of hematin in acute porphyric relapse].
Topics: Acute Disease; Adult; Aminolevulinic Acid; Coproporphyrins; Heme; Hemin; Humans; Male; Porphobilinog | 1979 |
Haem biosynthesis in cutaneous hepatic porphyria: comparison with alcoholism and liver disease.
Topics: 5-Aminolevulinate Synthetase; Aminolevulinic Acid; Coproporphyrins; Erythrocytes; Ferrochelatase; He | 1979 |
[Laboratory diagnosis of anomalies of porphyrin metabolism].
Topics: Aminolevulinic Acid; Humans; Methods; Porphobilinogen; Porphyrias; Porphyrins | 1979 |
[Hematin treatment of acute intermittent porphyria. A case report (author's transl)].
Topics: Adolescent; Aminolevulinic Acid; Antihypertensive Agents; Electromyography; Female; Heme; Hemin; Hum | 1979 |
[Acute intermittent porphyria--a clinical review].
Topics: Acute Disease; Aminolevulinic Acid; Diagnosis, Differential; Heme; Humans; Porphobilinogen; Porphyri | 1979 |
Determination of 5-aminolaevulinic acid and porphobilinogen by high-performance liquid chromatography.
Topics: Aminolevulinic Acid; Animals; Chromatography, High Pressure Liquid; Erythrocytes; Levulinic Acids; P | 1979 |
Studies in porphyria IX: Detection of the gene defect of erythropoietic protoporphyria in mitogen-stimulated human lymphocytes.
Topics: Adolescent; Adult; Aminolevulinic Acid; Cells, Cultured; Female; Heterozygote; Humans; Lymphocyte Ac | 1979 |
[Uroporphyrinogen-I-synthetase in erythrocytes in acute intermittent porphyria].
Topics: Adolescent; Aminolevulinic Acid; Ammonia-Lyases; Bulgaria; Erythrocytes; Female; Humans; Hydroxymeth | 1977 |
Family studies on the activity of uroporphyrinogen I synthase in diagnosis of acute intermittent porphyria.
Topics: Adolescent; Adult; Aged; Aminolevulinic Acid; Ammonia-Lyases; Clinical Enzyme Tests; Female; Humans; | 1978 |
Porphyrin precursors in acute porphyria.
Topics: Adult; Aminolevulinic Acid; Animals; Brain; Child; Humans; Levulinic Acids; Porphyrias | 1978 |
Early labelled bile pigment production in the porphyrias.
Topics: Aminolevulinic Acid; Anemia, Sickle Cell; Bile Pigments; Bilirubin; Erythrocytes; Erythropoiesis; Gl | 1978 |
Relationships between acute hepatic porphyrias due to genetic variability of primary enzyme defects and limiting function of uroporphyrinogen synthase.
Topics: 5-Aminolevulinate Synthetase; Acute Disease; Adolescent; Adult; Aged; Aminolevulinic Acid; Ammonia-L | 1978 |
Studies in porphyria. VI. Biosynthesis of porphyrins in mammalian skin and in the skin of porphyric patients.
Topics: Allylisopropylacetamide; Aminolevulinic Acid; Animals; Heme; Humans; Hydroxymethylbilane Synthase; L | 1977 |
Porphyrin synthesis in blood cells of patients with erythropoietic protoporphyria.
Topics: Aminolevulinic Acid; Coproporphyrins; Erythrocytes; Erythropoiesis; Female; Humans; Male; Porphyrias | 1977 |
Tyrosinemia with acute intermittent porphyria: aminolevulinic acid dehydratase deficiency related to elevated urinary aminolevulinic acid levels.
Topics: Adolescent; Amino Acid Metabolism, Inborn Errors; Aminolevulinic Acid; Catecholamines; Female; Human | 1977 |
[The effect of bloodletting on the excretion of porphyrius and clelta aminolevulinic acid as well as the clinical picture of porphyria cutanea tarda].
Topics: Adult; Aminolevulinic Acid; Bloodletting; Female; Humans; Levulinic Acids; Male; Middle Aged; Porphy | 1977 |
Pathogenesis of neural manifestations in acute porphyria.
Topics: 5-Aminolevulinate Synthetase; Acute Disease; Aminolevulinic Acid; Animals; Anura; Brain; Heme; Human | 1977 |
Plumbism from airborne lead in a firing range. An unusual exposure to a toxic heavy metal.
Topics: Adolescent; Air Pollution; Aminolevulinic Acid; Coproporphyrins; Diagnosis, Differential; Erythrocyt | 1977 |
Prophyrin precursors in blood, urine and cerebrospinal fluid in acute porphyria.
Topics: Acute Disease; Adult; Aminolevulinic Acid; Female; Humans; Middle Aged; Porphobilinogen; Porphyrias; | 1977 |
Catecholamine uptake, accumulation, and release in acute porphyria.
Topics: Acute Disease; Adolescent; Adult; Aminolevulinic Acid; Animals; Blood Platelets; Catecholamines; Ery | 1977 |
[Pathophysiology and diagnosis of acute intermittent porphyria].
Topics: Acute Disease; Aminolevulinic Acid; Erythrocytes; Humans; Hydroxymethylbilane Synthase; Porphobilino | 1977 |
Hereditary coproporphyria and epilepsy.
Topics: Aminolevulinic Acid; Child; Coproporphyrinogen Oxidase; Coproporphyrins; Epilepsy; Female; Humans; P | 1977 |
[Letter: Porphyria cutanea tarda: normalization of porphyrin-excretion following treatment with p-amino-benzoic acid (Potaba) (author's transl)].
Topics: Adult; Aminobenzoates; Aminolevulinic Acid; Female; Humans; Middle Aged; Porphobilinogen; Porphyrias | 1976 |
Hematin treatment of acute porphyria. Early remission of an almost fatal relapse.
Topics: Acute Disease; Adult; Aminolevulinic Acid; Female; Follow-Up Studies; Heme; Hemin; Humans; Infusions | 1976 |
Effect of lead on hepatic delta-aminolaevulinic acid synthetase activity in the rat: a model for drug sensitivity in intermittent acute porphyria.
Topics: 5-Aminolevulinate Synthetase; Aminolevulinic Acid; Animals; Cytochrome P-450 Enzyme System; Drug Hyp | 1976 |
[Liver changes in porphyria cutanea tarda. Part II].
Topics: Adult; Aminolevulinic Acid; Humans; Liver; Porphyrias; Porphyrinogens | 1976 |
Hexachlorobenzene porphyria in rats as a model for human chronic hepatic porphyrias.
Topics: Aminolevulinic Acid; Animals; Chlorobenzenes; Chronic Disease; Coproporphyrins; Disease Models, Anim | 1976 |
Turnover of erythrocyte protoporphyrin, with special reference to bovine porphyria and iron deficiency anemia.
Topics: Aminolevulinic Acid; Anemia, Hypochromic; Animals; Cattle; Erythrocytes; Humans; Porphyrias; Porphyr | 1976 |
Porphyrin biosynthesis from ALA and PBG by human erythrocytes in porphyrin disorders. Kinetic studies of the isomer series I and III.
Topics: Aminolevulinic Acid; Coproporphyrins; Erythrocytes; Hot Temperature; Humans; Isomerism; Kinetics; Le | 1976 |
Tissue uptake of o-aminolaevulinic acid.
Topics: Adipose Tissue; Aminolevulinic Acid; Animals; Brain; Carbon Radioisotopes; Digestive System; Kidney; | 1975 |
Porphobilinogen excretion in chemical induced porphyria: reversal by induction of porphobilinogen oxygenase.
Topics: Acetamides; Allylisopropylacetamide; Aminolevulinic Acid; Animals; Enzyme Induction; Fasting; Liver; | 1975 |
Effects of hematin in hepatic porphyria. Further studies.
Topics: Adult; Aminolevulinic Acid; Female; Heme; Hemin; Humans; Infusions, Parenteral; Liver; Male; Middle | 1975 |
Anesthesia and the porphyrias.
Topics: 5-Aminolevulinate Synthetase; Acute Disease; Aminolevulinic Acid; Ammonia-Lyases; Anesthesia; Anesth | 1975 |
[Acute intermittent porphyria. Detection of asymptomatic carriers of the genetic defect].
Topics: Acute Disease; Adolescent; Adult; Aged; Aminolevulinic Acid; Ammonia-Lyases; Child; Child, Preschool | 1975 |
Studies in porphyria. IV. Expression of the gene defect of acute intermittent porphyria in cultured human skin fibroblasts and amniotic cells: prenatal diagnosis of the porphyric trait.
Topics: Abortion, Induced; Adolescent; Adult; Aminolevulinic Acid; Ammonia-Lyases; Amniocentesis; Amniotic F | 1975 |
Hexachlorobenzene-induced porphyria in rats--relationship between prophyrin excretion and induction of drug metabolizing liver enzymes.
Topics: Aminolevulinic Acid; Aniline Hydroxylase; Animals; Chlorobenzenes; Cytochrome P-450 Enzyme System; D | 1975 |
Urinary excretion of 17-oxosteroids in hereditary coproporphyria.
Topics: 17-Ketosteroids; Adult; Aminolevulinic Acid; Androsterone; Coproporphyrins; Etiocholanolone; Female; | 1975 |
Regulation of rat liver tryptophan pyrrolase by its cofactor haem: Experiments with haematin and 5-aminolaevulinate and comparison with the substrate and hormonal mechanisms.
Topics: Aminolevulinic Acid; Apoenzymes; Cycloheximide; Dactinomycin; Hematinics; Heme; Hydrocortisone; Live | 1975 |
[High voltage electrophoretic screening test for the diagnosis of a hyper-delta-amino-levuline aciduria].
Topics: Aminolevulinic Acid; Electrophoresis; Humans; Lead Poisoning; Levulinic Acids; Porphyrias | 1975 |
Studies in porphyria. V. Drug oxidation rates in hereditary hepatic porphyria.
Topics: Adult; Aminolevulinic Acid; Antipyrine; Erythrocytes; Female; Half-Life; Humans; Hydroxymethylbilane | 1976 |
[Diagnostic and therapeutic problems in acute intermittent porphyria].
Topics: Acute Disease; Adrenal Cortex Hormones; Adult; Aminolevulinic Acid; Analgesics; Colic; Color; Diagno | 1976 |
Comparative effects of glycerol and dextrose on porphyrin precursor excretion in acute intermittent porphyria.
Topics: Acute Disease; Adolescent; Adult; Aged; Aminolevulinic Acid; Dietary Carbohydrates; Dietary Fats; Fe | 1976 |
[Accident in treatment of porphyria cutanea tarda by chloroquine (Resochin) (author's transl)].
Topics: Aminolevulinic Acid; Chloroquine; Humans; Liver; Male; Medication Errors; Middle Aged; Mitochondria, | 1976 |
The porphyrinogenic effects of kryptopyrrole in the rat and the occurrence of urinary kryptopyrrole in human hereditary hepatic porphyria.
Topics: Aminolevulinic Acid; Animals; Humans; Male; Porphyrias; Porphyrins; Pyrroles; Rats | 1976 |
Determination of plasma delta-aminolaevulinic acid levels. Applications.
Topics: Aminolevulinic Acid; Anticonvulsants; Female; Humans; Lead Poisoning; Male; Porphyrias; Renal Dialys | 1992 |
[Acute intermittent porphyria in pregnancy: glucose or hematin therapy?].
Topics: Acute Disease; Adult; Aminolevulinic Acid; Drug Therapy, Combination; Female; Glucose Solution, Hype | 1992 |
[What is your diagnosis? Acute intermittent porphyria].
Topics: Adult; Aminolevulinic Acid; Female; Humans; Porphobilinogen; Porphyrias; Porphyrins; Postoperative C | 1992 |
Inhibition of ferrochelatase and accumulation of porphyrins in mouse hepatocyte cultures exposed to porphyrinogenic chemicals.
Topics: Aminolevulinic Acid; Animals; Cells, Cultured; Chemical and Drug Induced Liver Injury; Dicarbethoxyd | 1992 |
5-aminolevulinic acid-induced alterations of oxidative metabolism in sedentary and exercise-trained rats.
Topics: Aminolevulinic Acid; Animals; Citrate (si)-Synthase; Female; Lead Poisoning; Metabolism; Mitochondri | 1992 |
Alcoholic beverages in acute porphyria.
Topics: Acute Disease; Alcoholic Beverages; Aminolevulinic Acid; Dose-Response Relationship, Drug; Genetic C | 1992 |
Frequency of low erythrocyte porphobilinogen deaminase activity in Finland.
Topics: Adult; Aminolevulinic Acid; Blood Donors; Erythrocytes; Female; Finland; Humans; Hydroxymethylbilane | 1992 |
[Evaluation of the effects of reduced glutathione in subjects with acquired and congenital changes in heme biosynthesis].
Topics: Aminolevulinic Acid; Coproporphyrins; Glutathione; Heme; Humans; Lead Poisoning; Porphyrias; Porphyr | 1992 |
Acute intermittent porphyria. A perplexing case.
Topics: Acute Disease; Aminolevulinic Acid; Female; Humans; Middle Aged; Nervous System Diseases; Pain; Porp | 1992 |
Sustained high plasma 5-aminolaevulinic acid concentration in a volunteer: no porphyric symptoms.
Topics: Aminolevulinic Acid; Hemodynamics; Humans; Male; Middle Aged; Nervous System; Porphyrias; Porphyrins | 1992 |
Influence of hepatic tumors caused by diethylnitrosamine on hexachlorobenzene-induced porphyria in rats.
Topics: 5-Aminolevulinate Synthetase; Aminolevulinic Acid; Animals; Carcinoma, Hepatocellular; Cytochrome P- | 1991 |
Intravenous heme-albumin in acute intermittent porphyria: evidence for repletion of hepatic hemoproteins and regulatory heme pools.
Topics: Acute Disease; Adult; Aminolevulinic Acid; Analysis of Variance; Cytochrome P-450 Enzyme System; Fem | 1991 |
Manifestation of acute intermittent porphyria in patients with chronic inflammatory bowel disease.
Topics: Acute Disease; Adolescent; Adult; Aminolevulinic Acid; Colitis, Ulcerative; Crohn Disease; Humans; P | 1991 |
Experimental latent and acute porphyria in the non-fasted rat; preventive effect of propranolol.
Topics: Acute Disease; Allylisopropylacetamide; Aminolevulinic Acid; Animals; Coproporphyrins; Dicarbethoxyd | 1991 |
Damage to rat liver mitochondria promoted by delta-aminolevulinic acid-generated reactive oxygen species: connections with acute intermittent porphyria and lead-poisoning.
Topics: Aminolevulinic Acid; Animals; Calcium; Cell Membrane Permeability; Lead Poisoning; Male; Membrane Po | 1991 |
Uroporphyria produced in mice by iron and 5-aminolevulinic acid.
Topics: Administration, Oral; Aminolevulinic Acid; Animals; Chemical and Drug Induced Liver Injury; Cytochro | 1991 |
delta-Aminolevulinate dehydratase deficient porphyria: identification of the molecular lesions in a severely affected homozygote.
Topics: Aminolevulinic Acid; Base Sequence; Exons; Gene Amplification; Genotype; Homozygote; Humans; Infant; | 1991 |
Elevation of hormone-binding globulins in acute intermittent porphyria.
Topics: Adolescent; Adult; Aminolevulinic Acid; Arginine; Carrier Proteins; Heme; Humans; Hydrocortisone; Li | 1990 |
A gonadotropin releasing hormone analogue prevents cyclical attacks of porphyria.
Topics: Adult; Aminolevulinic Acid; Female; Gonadotropin-Releasing Hormone; Humans; Menstrual Cycle; Periodi | 1990 |
A retrospective study of a patient with homozygous form of acute intermittent porphyria.
Topics: Acute Disease; Aminolevulinic Acid; Child, Preschool; Chromatography, High Pressure Liquid; Erythroc | 1990 |
Coexistent hereditary coproporphyria and congenital erythropoietic porphyria (Günther disease).
Topics: Aging; Aminolevulinic Acid; Coproporphyrins; Erythrocytes; Feces; Female; Hemolysis; Humans; Infant; | 1990 |
Safety of vancomycin in acute porphyria.
Topics: Acute Disease; Adult; Aminolevulinic Acid; Erythrocytes; Female; Humans; Hydroxymethylbilane Synthas | 1990 |
[Evaluation of porphyrinogenic effect of lindane in rats].
Topics: 5-Aminolevulinate Synthetase; Aminolevulinic Acid; Animals; Heme; Hexachlorocyclohexane; Levulinic A | 1986 |
Acute intermittent porphyria in two patients on anticonvulsant therapy and with normal erythrocyte porphobilinogen deaminase activity.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aminolevulinic Acid; Ammonia-Lyases; Anticonvulsants; Er | 1989 |
Free radical generation during delta-aminolevulinic acid autoxidation: induction by hemoglobin and connections with porphyrinpathies.
Topics: Aminolevulinic Acid; Animals; Cattle; Electron Spin Resonance Spectroscopy; Free Radicals; Humans; L | 1989 |
Uroporphyria caused by acetone and 5-aminolevulinic acid in iron-loaded mice.
Topics: Acetone; Aminolevulinic Acid; Animals; Disease Models, Animal; Drug Interactions; Iron-Dextran Compl | 1989 |
[Significance of delta-aminolevulinic acid synthase analysis in clinical tests].
Topics: Aminolevulinic Acid; Animals; Colorimetry; Fluorometry; Humans; Levulinic Acids; Liver; Liver Diseas | 1989 |
[Significance of delta-aminolevulinic acid analysis in clinical tests].
Topics: Amino Acid Metabolism, Inborn Errors; Aminolevulinic Acid; Chromatography, Gas; Chromatography, High | 1989 |
[Excretion of porphyrin and porphyrin precursor during ethylene oxide inhalation].
Topics: Administration, Inhalation; Aminolevulinic Acid; Animals; Coproporphyrins; Creatinine; Ethylene Oxid | 1989 |
The porphyrinogenic effect of simvastatin in experimental systems.
Topics: Aminolevulinic Acid; Animals; Anticholesteremic Agents; Chick Embryo; Chromatography, Thin Layer; Fe | 1989 |
Hepatobiliary implications and complications in protoporphyria, a 20-year study.
Topics: Adult; Aminolevulinic Acid; Child, Preschool; Chromatography, Ion Exchange; Chromatography, Thin Lay | 1989 |
Delta-aminolevulinic acid in plasma by free amino acid analysis.
Topics: Amino Acids; Aminolevulinic Acid; Hemin; Humans; Levulinic Acids; Porphyrias | 1989 |
Generation of active oxygen species during coupled autoxidation of oxyhemoglobin and delta-aminolevulinic acid.
Topics: Aminolevulinic Acid; Animals; Catalase; Cattle; Humans; Kinetics; Levulinic Acids; Mannitol; Methemo | 1986 |
Endogenously formed norharman (beta-carboline) in platelet rich plasma obtained from porphyric rats.
Topics: Alkaloids; Allylisopropylacetamide; Aminolevulinic Acid; Animals; Blood Platelets; Carbolines; Catal | 1986 |
Induction of acute renal porphyria in Japanese quail by Aroclor 1254.
Topics: 5-Aminolevulinate Synthetase; Aminolevulinic Acid; Animals; Aroclors; Chlorodiphenyl (54% Chlorine); | 1986 |
Mechanism of PCB-induced porphyria and yusho disease.
Topics: 5-Aminolevulinate Synthetase; Aminolevulinic Acid; Animals; Chick Embryo; Cytochrome P-450 Enzyme Sy | 1987 |
Increased oxidation of uroporphyrinogen by an inducible liver microsomal system. Possible relevance to drug-induced uroporphyria.
Topics: Aminolevulinic Acid; Animals; Benzoflavones; Cells, Cultured; Chick Embryo; Cytochrome P-450 CYP1A1; | 1988 |
Uroporphyria produced in mice by 20-methylcholanthrene and 5-aminolaevulinic acid.
Topics: Aminolevulinic Acid; Animals; Cytochrome P-450 CYP1A1; Cytochrome P-450 Enzyme System; Hexachloroben | 1988 |
Treatment of acute hepatic porphyria with hematin.
Topics: Acute Disease; Adult; Aged; Aminolevulinic Acid; Female; Heme; Hemin; Humans; Liver Diseases; Male; | 1988 |
Effect of anticonvulsant drugs on serum delta-aminolaevulinic acid levels in non-porphyric subjects.
Topics: Aminolevulinic Acid; Anticonvulsants; Humans; Levulinic Acids; Porphyrias | 1987 |
Lead effects on the heme biosynthetic pathway. Relationship to toxicity.
Topics: Aminolevulinic Acid; Antipyrine; Cytochromes; Heme; Humans; Lead Poisoning; Models, Biological; Porp | 1987 |
Polychemotherapy of acute myelogenous leukemia in a patient with acute intermittent porphyria.
Topics: Acute Disease; Adult; Aminolevulinic Acid; Antineoplastic Combined Chemotherapy Protocols; Chemical | 1987 |
The porphyrias.
Topics: Adolescent; Adult; Aminolevulinic Acid; beta Carotene; Bloodletting; Carotenoids; Child; Child, Pres | 1986 |
Aminolaevulinate dehydratase porphyria in infancy. A clinical and biochemical study.
Topics: Aminolevulinic Acid; Erythrocytes; Female; Humans; Infant, Newborn; Kinetics; Male; Pedigree; Porpho | 1987 |
Antipyrine metabolism in acute hepatic porphyria in relapse and remission.
Topics: 5-Aminolevulinate Synthetase; Adolescent; Adult; Aged; Aminolevulinic Acid; Antipyrine; Cytochrome P | 1987 |
Washington University case conference. Dual porphyria--an underdiagnosed entity?
Topics: Aminolevulinic Acid; Coproporphyrins; Diagnosis, Differential; Feces; Flavoproteins; Humans; Male; M | 1987 |
Clinical usefulness of cimetidine for the treatment of acute intermittent porphyria--a preliminary report.
Topics: 5-Aminolevulinate Synthetase; Acute Disease; Adult; Aminolevulinic Acid; Cimetidine; Humans; Liver D | 1987 |
delta-Aminolaevulinic acid in plasma, cerebrospinal fluid, saliva and erythrocytes: studies in normal, uraemic and porphyric subjects.
Topics: Adult; Aminolevulinic Acid; Erythrocytes; Female; Hemin; Humans; Kidney Failure, Chronic; Levulinic | 1987 |
[Acute porphyria: 2 clinical cases].
Topics: Acute Disease; Adult; Aminolevulinic Acid; Female; Humans; Liver; Porphobilinogen; Porphyrias; Porph | 1985 |
Influence of chloroquine on the porphyrin metabolism.
Topics: 7-Alkoxycoumarin O-Dealkylase; Aminolevulinic Acid; Aminopyrine N-Demethylase; Animals; Aryl Hydroca | 1985 |
Use of transcutaneous nerve stimulation in the attacks of acute intermittent porphyria.
Topics: Acute Disease; Adult; Aminolevulinic Acid; Electric Stimulation Therapy; Female; Humans; Porphobilin | 1985 |
Hyperinsulinemia in acute intermittent porphyria.
Topics: Acute Disease; Adolescent; Adult; Aminolevulinic Acid; Female; Glucose Tolerance Test; Humans; Hyper | 1985 |
[Acute porphyria in familial delta-aminolevulinic acid dehydrase deficiency].
Topics: Adult; Aminolevulinic Acid; Diagnosis, Differential; Erythrocytes; Genes, Dominant; Humans; Male; Po | 1985 |
Clinical and experimental investigations of vasopressin secretion in acute porphyrias.
Topics: Acute Disease; Aminolevulinic Acid; Animals; Arginine Vasopressin; Humans; Hypothalamo-Hypophyseal S | 1985 |
Protoporphyrin accumulation by mitogen stimulated lymphocytes and protoporphyrinogen oxidase activity in patients with porphyria variegata and erythropoietic protoporphyria: evidence for deficiency of protoporphyrinogen oxidase and ferrochelatase in both
Topics: Adult; Aminolevulinic Acid; Child; Edetic Acid; Ferrochelatase; Flavoproteins; Humans; Iron; Liver D | 1985 |
Variant of acute intermittent porphyria with normal erythrocyte uroporphyrinogen-I-synthase activity.
Topics: Acute Disease; Adult; Aminolevulinic Acid; Ammonia-Lyases; Erythrocytes; Humans; Hydroxymethylbilane | 1985 |
[Clinical manifestations of acute intermittent porphyria (review of the literature)].
Topics: Acute Disease; Adolescent; Aminolevulinic Acid; Diagnosis, Differential; Diagnostic Errors; Female; | 1986 |
[Acute intermittent porphyria with clinical symptoms of an atypical polyradiculoneuropathy].
Topics: Acute Disease; Adolescent; Aminolevulinic Acid; Diagnosis, Differential; Female; Humans; Menstruatio | 1985 |
[Porphyrins and their precursors in the urine of patients with suspected porphyria; a 16-year experience].
Topics: Adult; Aminolevulinic Acid; Female; Humans; Levulinic Acids; Male; Middle Aged; Porphobilinogen; Por | 1985 |
"Glucose effect" and rate limiting function of uroporphyrinogen synthase on porphyrin metabolism in hepatocyte culture: relationship with human acute hepatic porphyrias.
Topics: 5-Aminolevulinate Synthetase; Aminolevulinic Acid; Ammonia-Lyases; Animals; Cells, Cultured; Chick E | 1985 |
[Experimental porphyria model with hexachlorocyclohexane].
Topics: Aminolevulinic Acid; Animals; Chlorobenzenes; Diet; Disease Models, Animal; Feces; Female; Hexachlor | 1974 |
The reversal of experimental porphyria and the prevention of induction of hepatic mixed-function oxidase by acetate.
Topics: 5-Aminolevulinate Synthetase; Acetates; Aminolevulinic Acid; Animals; Cytochrome c Group; Cytochrome | 1974 |
[Genetic prognosis of a mother with acute intermittent porphyria (hepatic form)].
Topics: Acute Disease; Adolescent; Adult; Aminolevulinic Acid; Female; Genes, Dominant; Genetic Counseling; | 1974 |
A red cell enzyme method for the diagnosis of acute intermittent porphyria.
Topics: Acute Disease; Aminolevulinic Acid; Ammonia-Lyases; Erythrocytes; Freezing; Hemolysis; Hot Temperatu | 1974 |
Lead poisoning with low blood lead levels.
Topics: Adult; Aminolevulinic Acid; Hemoglobins; Humans; Lead; Lead Poisoning; Male; Occupational Diseases; | 1974 |
Comparative aspects of porphyria in man and animals.
Topics: Adult; Aminolevulinic Acid; Animals; Cattle; Drug Stability; Female; Genes, Recessive; Heme; Heteroz | 1974 |
Isotopic studies of porphyrin and heme metabolism: bonanzas and pitfalls.
Topics: Aminolevulinic Acid; Anemia, Hemolytic; Antimetabolites; Bilirubin; Carbon Radioisotopes; Erythrocyt | 1974 |
[Comments on paper "Zwei Suchteste für Porphyrein". (Doss, M. and Schmidt, A., (1972) this j. 10 (230-231)].
Topics: Acetates; Aminolevulinic Acid; Chloroform; Coloring Agents; Humans; Indicators and Reagents; Methods | 1973 |