Page last updated: 2024-10-16

aminolevulinic acid and Pancreatic Neoplasms

aminolevulinic acid has been researched along with Pancreatic Neoplasms in 12 studies

Aminolevulinic Acid: A compound produced from succinyl-CoA and GLYCINE as an intermediate in heme synthesis. It is used as a PHOTOCHEMOTHERAPY for actinic KERATOSIS.
5-aminolevulinic acid : The simplest delta-amino acid in which the hydrogens at the gamma position are replaced by an oxo group. It is metabolised to protoporphyrin IX, a photoactive compound which accumulates in the skin. Used (in the form of the hydrochloride salt)in combination with blue light illumination for the treatment of minimally to moderately thick actinic keratosis of the face or scalp.

Pancreatic Neoplasms: Tumors or cancer of the PANCREAS. Depending on the types of ISLET CELLS present in the tumors, various hormones can be secreted: GLUCAGON from PANCREATIC ALPHA CELLS; INSULIN from PANCREATIC BETA CELLS; and SOMATOSTATIN from the SOMATOSTATIN-SECRETING CELLS. Most are malignant except the insulin-producing tumors (INSULINOMA).

Research Excerpts

ExcerptRelevanceReference
"5-aminolevulinic acid(5-ALA)is an endogenous natural amino acid and precursor of the heme pathway."1.48[A Useful Case of Photodynamic Diagnosis of Inferior Vena Cava Invasion by Pancreatic Head Cancer Using 5-Aminolevulinic Acid(5-ALA)]. ( Arita, T; Fujiwara, H; Ikoma, H; Konishi, H; Kosuga, T; Kuriu, Y; Mizutani, T; Morimura, R; Murayama, Y; Nakanishi, M; Okamoto, K; Otsuji, E; Shiozaki, A, 2018)
"Since pancreatic cancer invasion to the inferior vena cava(IVC)was suspected during the operation, fluorescence observation was undergone."1.48[A Useful Case of Photodynamic Diagnosis of Inferior Vena Cava Invasion by Pancreatic Head Cancer Using 5-Aminolevulinic Acid(5-ALA)]. ( Arita, T; Fujiwara, H; Ikoma, H; Konishi, H; Kosuga, T; Kuriu, Y; Mizutani, T; Morimura, R; Murayama, Y; Nakanishi, M; Okamoto, K; Otsuji, E; Shiozaki, A, 2018)
"However, its effect on pancreatic cancer cells remains unclear."1.40Sonodynamically induced anti-tumor effect of 5-aminolevulinic acid on pancreatic cancer cells. ( Bai, YX; Du, XX; Han, Y; Huang, P; Jia, de X; Jiang, CL; Lang, XH; Li, YJ; Liu, L; Liu, T; Sui, H; Tian, Y; Wang, LY; Wei, XL; Xie, R; Yuan, HH; Zhang, TT; Zhang, WJ; Zhou, JH, 2014)

Research

Studies (12)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's2 (16.67)18.2507
2000's1 (8.33)29.6817
2010's5 (41.67)24.3611
2020's4 (33.33)2.80

Authors

AuthorsStudies
Hirao, M2
Hosui, A2
Mimura, A2
Ohnishi, K2
Tanimoto, T2
Okahara, T1
Sueyoshi, Y1
Goto, T1
Yamada, T2
Hiramatsu, N2
Kusumoto, Y1
Yamaguchi, T1
Miwa, H1
Saito, T1
Ebihara, Y1
Li, L1
Shirosaki, T1
Iijima, H1
Tanaka, K1
Nakanishi, Y1
Asano, T1
Noji, T1
Kurashima, Y1
Murakami, S1
Nakamura, T1
Tsuchikawa, T1
Okamura, K1
Shichinohe, T1
Hirano, S1
Mizutani, T1
Murayama, Y1
Ikoma, H1
Arita, T1
Kosuga, T1
Konishi, H1
Morimura, R1
Shiozaki, A1
Kuriu, Y1
Nakanishi, M1
Fujiwara, H1
Okamoto, K1
Otsuji, E1
Abd-Elgaliel, WR1
Cruz-Monserrate, Z1
Wang, H1
Logsdon, CD1
Tung, CH1
Li, YJ1
Huang, P1
Jiang, CL1
Jia, de X1
Du, XX1
Zhou, JH1
Han, Y1
Sui, H1
Wei, XL1
Liu, L1
Yuan, HH1
Zhang, TT1
Zhang, WJ1
Xie, R1
Lang, XH1
Wang, LY1
Liu, T1
Bai, YX1
Tian, Y1
Ikeura, T2
Takaoka, M2
Uchida, K2
Shimatani, M2
Miyoshi, H2
Kato, K1
Ohe, C1
Uemura, Y1
Kaibori, M2
Kwon, AH1
Okazaki, K2
Hasan, T1
Ratcliffe, SL1
Matthews, EK2
Regula, J1
Ravi, B1
Bedwell, J1
MacRobert, AJ1
Bown, SG1
Whitaker, CJ1
Battah, SH1
Forsyth, MJ1
Edwards, C1
Boyle, RW1
Hori, Y1
Mitsuyama, T1
Ota, U1
Kamiya, A1
Takahashi, K1
Ishizuka, M1

Other Studies

12 other studies available for aminolevulinic acid and Pancreatic Neoplasms

ArticleYear
Significance of in vitro photodynamic cytodiagnosis with 5-aminolevulinic acid in biliary brush cytology for malignant biliary stricture.
    Photodiagnosis and photodynamic therapy, 2022, Volume: 38

    Topics: Aminolevulinic Acid; Bile Duct Neoplasms; Cholestasis; Constriction, Pathologic; Cytodiagnosis; Huma

2022
Significance of in vitro photodynamic cytodiagnosis using 5-aminolevulinic acid in solid pancreatic tumors extracted by endoscopic ultrasound-guided fine-needle aspiration.
    Photodiagnosis and photodynamic therapy, 2021, Volume: 33

    Topics: Aged; Aminolevulinic Acid; Endoscopic Ultrasound-Guided Fine Needle Aspiration; Humans; Male; Pancre

2021
A novel laparoscopic near-infrared fluorescence spectrum system for photodynamic diagnosis of peritoneal dissemination in pancreatic cancer.
    Photodiagnosis and photodynamic therapy, 2021, Volume: 33

    Topics: Aminolevulinic Acid; Animals; Fluorescence; Humans; Laparoscopy; Mice; Pancreatic Neoplasms; Periton

2021
[A Useful Case of Photodynamic Diagnosis of Inferior Vena Cava Invasion by Pancreatic Head Cancer Using 5-Aminolevulinic Acid(5-ALA)].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2018, Volume: 45, Issue:3

    Topics: Aged; Aminolevulinic Acid; Humans; Male; Pancreatic Neoplasms; Photosensitizing Agents; Protoporphyr

2018
Pancreatic cancer-associated Cathepsin E as a drug activator.
    Journal of controlled release : official journal of the Controlled Release Society, 2013, May-10, Volume: 167, Issue:3

    Topics: Aminolevulinic Acid; Animals; Carcinoma, Pancreatic Ductal; Cathepsin E; Cell Line, Tumor; Humans; L

2013
Sonodynamically induced anti-tumor effect of 5-aminolevulinic acid on pancreatic cancer cells.
    Ultrasound in medicine & biology, 2014, Volume: 40, Issue:11

    Topics: Aminolevulinic Acid; Apoptosis; Blotting, Western; Cell Line, Tumor; Cell Survival; Flow Cytometry;

2014
Fluorescence cytology with 5-aminolevulinic acid in EUS-guided FNA as a method for differentiating between malignant and benign lesions (with video).
    Gastrointestinal endoscopy, 2015, Volume: 81, Issue:6

    Topics: Adult; Aged; Aminolevulinic Acid; Cytological Techniques; Diagnosis, Differential; Endoscopic Ultras

2015
Using cellular mechanisms to develop effective combinations of photodynamic therapy and targeted therapies.
    Journal of the National Comprehensive Cancer Network : JNCCN, 2012, Oct-01, Volume: 10 Suppl 2

    Topics: Aminolevulinic Acid; Animals; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Cetuximab;

2012
Modification of the photodynamic action of delta-aminolaevulinic acid (ALA) on rat pancreatoma cells by mitochondrial benzodiazepine receptor ligands.
    British journal of cancer, 1995, Volume: 71, Issue:2

    Topics: Aminolevulinic Acid; Animals; Benzodiazepines; Benzodiazepinones; Cell Division; Cell Survival; Clon

1995
Photodynamic therapy using 5-aminolaevulinic acid for experimental pancreatic cancer--prolonged animal survival.
    British journal of cancer, 1994, Volume: 70, Issue:2

    Topics: Administration, Oral; Aminolevulinic Acid; Animals; Cricetinae; Disease Models, Animal; Female; Heme

1994
Photosensitization of pancreatic tumour cells by delta-aminolaevulinic acid esters.
    Anti-cancer drug design, 2000, Volume: 15, Issue:3

    Topics: Aminolevulinic Acid; Animals; Biological Transport, Active; Carrier Proteins; Esters; Pancreatic Neo

2000
Effectiveness of Photodynamic Screening Using 5-Aminolevulinic Acid for the Diagnosis of Pancreatic Cancer.
    Anticancer research, 2020, Volume: 40, Issue:6

    Topics: Aged; Aminolevulinic Acid; Biomarkers; Biomarkers, Tumor; Early Detection of Cancer; Female; Humans;

2020