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aminolevulinic acid and Paget Disease, Extramammary

aminolevulinic acid has been researched along with Paget Disease, Extramammary in 36 studies

Aminolevulinic Acid: A compound produced from succinyl-CoA and GLYCINE as an intermediate in heme synthesis. It is used as a PHOTOCHEMOTHERAPY for actinic KERATOSIS.
5-aminolevulinic acid : The simplest delta-amino acid in which the hydrogens at the gamma position are replaced by an oxo group. It is metabolised to protoporphyrin IX, a photoactive compound which accumulates in the skin. Used (in the form of the hydrochloride salt)in combination with blue light illumination for the treatment of minimally to moderately thick actinic keratosis of the face or scalp.

Paget Disease, Extramammary: A rare cutaneous neoplasm that occurs in the elderly. It develops more frequently in women and predominantly involves apocrine gland-bearing areas, especially the vulva, scrotum, and perianal areas. The lesions develop as erythematous scaly patches that progress to crusted, pruritic, erythematous plaques. The clinical differential diagnosis includes squamous cell carcinoma in situ and superficial fungal infection. It is generally thought to be an adenocarcinoma of the epidermis, from which it extends into the contiguous epithelium of hair follicles and eccrine sweat ducts. (DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p1478)

Research Excerpts

ExcerptRelevanceReference
" All patients were able to complete the treatment protocol, with well cosmetic results and no moderate adverse reactions."2.80Efficacy and safety of topical ALA-PDT in the treatment of EMPD. ( Fan, DL; Gao, Y; Lu, YG; Wang, HL; Wang, WS; Yang, Y; Zhang, XC, 2015)
"We present one case of vulvar extramammary Paget's disease (EMPD), that is a female patient with lesions in the vulva and involving the urethra."1.91Efficacy of hematoporphyrin injection (HpD) photodynamic therapy in the treatment of widespread extramammary Paget's disease. ( Li, Y; Liu, R; Liu, X; Ma, G; Ma, T; Tang, Y; Xiang, X, 2023)
" The purpose of this study was to illustrate the efficiency and safety of PDD-guided tumor excision combined with ALA-PDT in patients with extramammary Paget's disease (EMPD)."1.72PDD-guided tumor excision combined with photodynamic therapy in patients with extramammary Paget's disease. ( Kou, H; Li, X; Lu, Y; Yang, Y; Zhao, C; Zhu, F, 2022)
"In our study, 7 cases of EMPD were treated with PDD-guided tumor excision combined with ALA-PDT."1.72PDD-guided tumor excision combined with photodynamic therapy in patients with extramammary Paget's disease. ( Kou, H; Li, X; Lu, Y; Yang, Y; Zhao, C; Zhu, F, 2022)
"To evaluate the value of Wood's lamp examination combined with 5-aminolevulinic acid (5-ALA) photodynamic therapy (PDT) to determine positive tumor margins in patients with extramammary Paget's disease (EMPD) before surgery."1.62The application of Wood's lamp combined with 5-aminolevulinic acid for defining tumor margins in patients with extramammary Paget's disease. ( Fu, B; Li, J; Lou, Y; Song, C; Zhou, P, 2021)
" In the 5-ALA-PDT group, Wood's lamp examination combined with 5-ALA-PDT was used to trace the fluorescence range, and multipoint biopsy was performed according to the pathology to determine the final excision scope."1.62The application of Wood's lamp combined with 5-aminolevulinic acid for defining tumor margins in patients with extramammary Paget's disease. ( Fu, B; Li, J; Lou, Y; Song, C; Zhou, P, 2021)
"Wood's lamp examination combined with 5-ALA-PDT may predict tumor margins in EMPD."1.62The application of Wood's lamp combined with 5-aminolevulinic acid for defining tumor margins in patients with extramammary Paget's disease. ( Fu, B; Li, J; Lou, Y; Song, C; Zhou, P, 2021)
"To investigate the safety and efficacy of wide local excision combined with aminolevulinic acid (ALA) photodynamic therapy (PDT) for the treatment of scrotal Paget's disease in patients of advanced age."1.56Excision combined with photodynamic therapy for scrotal Paget's disease in patients aged over 60 years. ( Chen, M; Chen, X; Dai, Y; Li, D; Yang, Z; Zhang, X, 2020)
"44 years) with scrotal Paget's disease treated with wide local excision combined with ALA PDT and followed up from June 2014 to February 2018."1.56Excision combined with photodynamic therapy for scrotal Paget's disease in patients aged over 60 years. ( Chen, M; Chen, X; Dai, Y; Li, D; Yang, Z; Zhang, X, 2020)
"Wide local excision combined with ALA PDT shows good clinical efficacy and a low complication rate in patients of advanced age with scrotal Paget's disease."1.56Excision combined with photodynamic therapy for scrotal Paget's disease in patients aged over 60 years. ( Chen, M; Chen, X; Dai, Y; Li, D; Yang, Z; Zhang, X, 2020)
"Initial surgical margins were determined by FD or FD plus MSB."1.48Clinical Benefits of Preoperative Conventional Fluorescence Diagnosis in Surgical Treatment of Extramammary Paget Disease. ( Chen, Z; Ma, H; Wan, M; Xie, L; Zhao, Y, 2018)
"In conclusion, photodynamic therapy for extramammary Paget's disease is not recommended as the first option except for scrotal cases or lesions < 4 cm in diameter."1.36Long-term follow-up of in situ extramammary Paget's disease in Asian skin types IV/V treated with photodynamic therapy. ( Gao, T; Hu, X; Jiao, B; Li, C; Li, Q; Liao, W; Long, HA; Lv, Y; Qi, X; Qiao, H; Wang, L; Wang, S, 2010)
"We evaluated the clinical response, recurrence and adverse events of photodynamic therapy for in situ extramammary Paget's disease in 14 male and 3 female Chinese patients with 21 lesions."1.36Long-term follow-up of in situ extramammary Paget's disease in Asian skin types IV/V treated with photodynamic therapy. ( Gao, T; Hu, X; Jiao, B; Li, C; Li, Q; Liao, W; Long, HA; Lv, Y; Qi, X; Qiao, H; Wang, L; Wang, S, 2010)
"In the present study, five patients with extramammary Paget's disease with a total of eight lesions first underwent carbon dioxide (CO2) laser abrasion, followed by 3 h of occlusive application of aminolaevulinic acid (ALA) and then 100 J/cm2 irradiation with a 630-nm excimer dye laser."1.35Photodynamic therapy following carbon dioxide laser enhances efficacy in the treatment of extramammary Paget's disease. ( Fukui, T; Matsumoto, Y; Tamada, Y; Watanabe, D, 2009)
"They included squamous cell carcinoma (SCC), basal cell carcinoma (BCC), Bowen's disease (BD), mammary and extramammary Paget disease, actinic keratosis (AK) and erythroplasia of Queyrat."1.35Treatment of skin cancer and pre-cancer using topical ALA-PDT--a single hospital experience. ( Guo, MX; Wang, HW; Wang, XL; Xu, SZ, 2008)
"So far, we have treated 76 cases of skin cancer and pre-cancer using topical ALA-PDT."1.35Treatment of skin cancer and pre-cancer using topical ALA-PDT--a single hospital experience. ( Guo, MX; Wang, HW; Wang, XL; Xu, SZ, 2008)

Research

Studies (36)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (2.78)18.2507
2000's9 (25.00)29.6817
2010's20 (55.56)24.3611
2020's6 (16.67)2.80

Authors

AuthorsStudies
Li, X2
Zhao, C1
Kou, H1
Zhu, F1
Yang, Y2
Lu, Y1
Sachdeva, M1
Tai, F1
Bargman, H1
Xiang, X1
Li, Y1
Tang, Y1
Liu, R1
Ma, T1
Liu, X1
Ma, G1
Shim, PJ1
Zeitouni, NC4
Zhou, P1
Li, J1
Song, C1
Lou, Y1
Fu, B1
Wan, M1
Ma, H1
Zhao, Y1
Xie, L1
Chen, Z1
Peng, X1
Qian, W1
Hou, J1
Theresia, C1
Zheng, J1
Chen, XY1
Bauman, TM1
Rosman, IS1
Sheinbein, DM1
Shen, S1
Zhang, G2
Wang, P2
Zhang, Y2
Keyal, U1
Ji, J1
Wang, X2
Rioli, DI1
Samimi, M1
Beneton, N1
Hainaut, E1
Martin, L1
Misery, L1
Quereux, G1
Chen, M1
Chen, X1
Dai, Y1
Yang, Z1
Zhang, X1
Li, D1
Li, C2
Guo, L1
Shi, L1
Sun, X1
Hu, C1
Zhang, L2
Fontanelli, R2
Papadia, A1
Martinelli, F1
Lorusso, D1
Grijuela, B1
Merola, M1
Solima, E2
Ditto, A2
Raspagliesi, F2
Wang, HW2
Lv, T1
Zhang, LL1
Lai, YX1
Tang, L1
Tang, YC1
Huang, Z2
Wang, XL2
Jing, W1
Juan, X1
Jiayuan, C1
Qin, H1
Qing, L1
Shengmei, X1
Gao, Y1
Zhang, XC1
Wang, WS1
Wang, HL1
Lu, YG1
Fan, DL1
Youssef, AA1
Reygagne, P1
Vicentini, C1
Carpentier, O1
Lecomte, F1
Thecua, E1
Mortier, L1
Mordon, SR1
Li, L1
Deng, Y1
Liao, W2
Luo, R1
Fukui, T1
Watanabe, D2
Tamada, Y3
Matsumoto, Y3
Guo, MX1
Xu, SZ1
Li, Q1
Gao, T1
Jiao, B1
Qi, X1
Long, HA1
Qiao, H1
Wang, L1
Lv, Y1
Hu, X1
Wang, S1
Housel, JP1
Izikson, L1
Cherpelis, BS1
Kitagawa, KH1
Bogner, P1
Kriz, M1
Hegyi, J1
Ruzicka, T1
Berking, C1
Al Yousef, A1
Boccara, O1
Moyal-Barracco, M1
Zimmermann, U1
Saiag, P1
Longo-Imedio, MI1
Araki, Y1
Noake, T1
Hata, H1
Momosaki, K1
Shirouzu, K1
Akita, Y1
Kozaki, K1
Nakagawa, A1
Saito, T1
Ito, S1
Fujiwara, S1
Nishikawa, N1
Uchida, K1
Yoshikawa, K1
Noguchi, T1
Miyaishi, O1
Shimozato, K1
Saga, S1
Zawislak, AA1
McCarron, PA1
McCluggage, WG1
Price, JH1
Donnelly, RF1
McClelland, HR1
Dobbs, SP1
Woolfson, AD1
Mikasa, K1
Kondo, C1
Kobayashi, M2
Nakaseko, H1
Yokoo, K1
Rossi, G1
Hanozet, F1
Kusamura, S1
Henta, T1
Itoh, Y1
Ninomiya, Y1
Ishibashi, A1
Shieh, S1
Dee, AS1
Cheney, RT1
Frawley, NP1
Oseroff, AR1

Reviews

3 reviews available for aminolevulinic acid and Paget Disease, Extramammary

ArticleYear
Treatment Outcomes of Adjunct and Stand-alone Photodynamic Therapy in Patients With Extramammary Paget Disease: A Literature Review.
    Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.], 2023, 05-01, Volume: 49, Issue:5

    Topics: Aminolevulinic Acid; Humans; Imiquimod; Paget Disease, Extramammary; Photochemotherapy; Photosensiti

2023
Photodynamic therapy for extramammary Paget's disease: A systematic review of the literature.
    Photodiagnosis and photodynamic therapy, 2020, Volume: 31

    Topics: Aminolevulinic Acid; Dihematoporphyrin Ether; Humans; Paget Disease, Extramammary; Photochemotherapy

2020
Topical ALA-PDT as alternative therapeutic option in treatment-recalcitrant dermatosis: Report of 4 cases.
    Photodiagnosis and photodynamic therapy, 2017, Volume: 20

    Topics: Acne Vulgaris; Adolescent; Adult; Aged, 80 and over; Aminolevulinic Acid; Condylomata Acuminata; Fem

2017

Trials

4 trials available for aminolevulinic acid and Paget Disease, Extramammary

ArticleYear
Photodynamic therapy with M-ALA as non surgical treatment option in patients with primary extramammary Paget's disease.
    Gynecologic oncology, 2013, Volume: 130, Issue:1

    Topics: Aged; Aged, 80 and over; Aminolevulinic Acid; Female; Humans; Middle Aged; Paget Disease, Extramamma

2013
A prospective pilot study to evaluate combined topical photodynamic therapy and surgery for extramammary paget's disease.
    Lasers in surgery and medicine, 2013, Volume: 45, Issue:5

    Topics: Administration, Topical; Aged; Aged, 80 and over; Aminolevulinic Acid; Cohort Studies; Combined Moda

2013
Efficacy and safety of topical ALA-PDT in the treatment of EMPD.
    Photodiagnosis and photodynamic therapy, 2015, Volume: 12, Issue:1

    Topics: Administration, Cutaneous; Aged; Aged, 80 and over; Aminolevulinic Acid; Combined Modality Therapy;

2015
Photodynamic therapy using a methyl ester of 5-aminolevulinic acid in recurrent Paget's disease of the vulva: a pilot study.
    Gynecologic oncology, 2006, Volume: 103, Issue:2

    Topics: Aged; Aminolevulinic Acid; Female; Humans; Middle Aged; Neoplasm Recurrence, Local; Paget Disease, E

2006

Other Studies

29 other studies available for aminolevulinic acid and Paget Disease, Extramammary

ArticleYear
PDD-guided tumor excision combined with photodynamic therapy in patients with extramammary Paget's disease.
    Photodiagnosis and photodynamic therapy, 2022, Volume: 38

    Topics: Aminolevulinic Acid; Humans; Margins of Excision; Paget Disease, Extramammary; Photochemotherapy; Ph

2022
Efficacy of hematoporphyrin injection (HpD) photodynamic therapy in the treatment of widespread extramammary Paget's disease.
    Photodiagnosis and photodynamic therapy, 2023, Volume: 42

    Topics: Aminolevulinic Acid; Female; Hematoporphyrin Derivative; Hematoporphyrins; Humans; Paget Disease, Ex

2023
The application of Wood's lamp combined with 5-aminolevulinic acid for defining tumor margins in patients with extramammary Paget's disease.
    Photodiagnosis and photodynamic therapy, 2021, Volume: 35

    Topics: Aminolevulinic Acid; Humans; Margins of Excision; Neoplasm Recurrence, Local; Paget Disease, Extrama

2021
Clinical Benefits of Preoperative Conventional Fluorescence Diagnosis in Surgical Treatment of Extramammary Paget Disease.
    Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.], 2018, Volume: 44, Issue:3

    Topics: Aged; Aged, 80 and over; Aminolevulinic Acid; Biopsy; Female; Fluorescence; Frozen Sections; Humans;

2018
5-aminolevulinic acid (5-ALA) fluorescence-guided Mohs surgery resection of penile-scrotal extramammary Paget's disease.
    Bioscience trends, 2017, Nov-20, Volume: 11, Issue:5

    Topics: Aged; Aminolevulinic Acid; Disease-Free Survival; Humans; Male; Margins of Excision; Mohs Surgery; O

2017
Extramammary Paget's disease of the scrotum with complete response to imiquimod and photodynamic therapy.
    BMJ case reports, 2018, Mar-05, Volume: 2018

    Topics: Administration, Topical; Aged; Aminolevulinic Acid; Aminoquinolines; Antineoplastic Agents; Biopsy;

2018
ALA-PDT as palliative care in a patient with secondary perineum EMPD.
    Photodiagnosis and photodynamic therapy, 2018, Volume: 22

    Topics: Aged; Aminolevulinic Acid; Humans; Male; Paget Disease, Extramammary; Palliative Care; Photochemothe

2018
Efficacy and tolerance of photodynamic therapy for vulvar Paget's disease: a multicentric retrospective study.
    European journal of dermatology : EJD, 2018, Jun-01, Volume: 28, Issue:3

    Topics: Aged; Aged, 80 and over; Aminolevulinic Acid; Female; Follow-Up Studies; Humans; Middle Aged; Neopla

2018
Excision combined with photodynamic therapy for scrotal Paget's disease in patients aged over 60 years.
    The aging male : the official journal of the International Society for the Study of the Aging Male, 2020, Volume: 23, Issue:5

    Topics: Aged; Aminolevulinic Acid; Humans; Male; Paget Disease, Extramammary; Photochemotherapy; Scrotum; Tr

2020
ALA-PDT combined with holmium laser therapy of postoperative recurrent extramammary Paget's disease.
    Photodiagnosis and photodynamic therapy, 2019, Volume: 27

    Topics: Aged; Aminolevulinic Acid; Combined Modality Therapy; Humans; Lasers, Solid-State; Low-Level Light T

2019
Complete remission of two patients with recurrent and wide spread extramammary Paget disease obtained from 5-aminolevulinic acid-based photodynamic therapy and imiquimod combination treatment.
    Photodiagnosis and photodynamic therapy, 2014, Volume: 11, Issue:3

    Topics: Aged; Aminolevulinic Acid; Aminoquinolines; Antineoplastic Agents; Drug Therapy, Combination; Genita

2014
Successful treatment of extramammary Paget's disease of the scalp with photodynamic therapy.
    International journal of dermatology, 2016, Volume: 55, Issue:5

    Topics: Aged, 80 and over; Aminolevulinic Acid; Head and Neck Neoplasms; Humans; Male; Paget Disease, Extram

2016
Treatment of a vulvar Paget's disease by photodynamic therapy with a new light emitting fabric based device.
    Lasers in surgery and medicine, 2017, Volume: 49, Issue:2

    Topics: Aminolevulinic Acid; Female; Humans; Middle Aged; Paget Disease, Extramammary; Photochemotherapy; Ph

2017
Treatment of perianal Paget's disease using photodynamic therapy with assistance of fluorescence examination: case report.
    Lasers in medical science, 2009, Volume: 24, Issue:6

    Topics: Aged; Aminolevulinic Acid; Anus Neoplasms; Female; Fluorescence; Humans; Laser Therapy; Paget Diseas

2009
Photodynamic therapy following carbon dioxide laser enhances efficacy in the treatment of extramammary Paget's disease.
    Acta dermato-venereologica, 2009, Volume: 89, Issue:2

    Topics: Aged; Aged, 80 and over; Aminolevulinic Acid; Combined Modality Therapy; Female; Humans; Lasers, Exc

2009
Treatment of skin cancer and pre-cancer using topical ALA-PDT--a single hospital experience.
    Photodiagnosis and photodynamic therapy, 2008, Volume: 5, Issue:2

    Topics: Administration, Topical; Adult; Aged; Aminolevulinic Acid; Carcinoma, Basal Cell; Carcinoma, Squamou

2008
Long-term follow-up of in situ extramammary Paget's disease in Asian skin types IV/V treated with photodynamic therapy.
    Acta dermato-venereologica, 2010, Volume: 90, Issue:2

    Topics: Administration, Cutaneous; Aged; Aged, 80 and over; Aminolevulinic Acid; Asian People; Carcinoma in

2010
Noninvasive extramammary Paget's disease treated with photodynamic therapy: case series from the Roswell Park Cancer Institute.
    Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.], 2010, Volume: 36, Issue:11

    Topics: Administration, Topical; Aged; Aged, 80 and over; Aminolevulinic Acid; Dihematoporphyrin Ether; Fema

2010
Shining the light on photodynamic therapy in the treatment of extramammary Paget's disease.
    Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.], 2010, Volume: 36, Issue:11

    Topics: Aminolevulinic Acid; Dihematoporphyrin Ether; Humans; Paget Disease, Extramammary; Photochemotherapy

2010
Photodynamic therapy with methyl-aminolevulinate for the treatment of double extramammary Paget's disease.
    Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.], 2011, Volume: 37, Issue:7

    Topics: Aged; Aminolevulinic Acid; Axilla; Humans; Male; Paget Disease, Extramammary; Photochemotherapy; Pho

2011
Fluorescence diagnostics as a guide for demarcation and biopsy of suspected anal cancer.
    International journal of dermatology, 2012, Volume: 51, Issue:1

    Topics: Aged; Aminolevulinic Acid; Anus Neoplasms; Biopsy; Carcinoma; Eczema; Female; Fluorescence; Humans;

2012
Incomplete efficacy of 5-aminolevulinic acid (5 ALA) photodynamic therapy in the treatment of widespread extramammary Paget's disease.
    Photodermatology, photoimmunology & photomedicine, 2012, Volume: 28, Issue:1

    Topics: Aged; Aminolevulinic Acid; Female; Genital Diseases, Male; Humans; Male; Paget Disease, Extramammary

2012
Letter: Photodynamic therapy with methyl-aminolevulinate for the treatment of double extramammary Paget's disease.
    Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.], 2013, Volume: 39, Issue:1 Pt 1

    Topics: Aminolevulinic Acid; Humans; Male; Paget Disease, Extramammary; Photochemotherapy; Photosensitizing

2013
Perianal Paget's disease treated with a wide excision and gluteal fold flap reconstruction guided by photodynamic diagnosis: report of a case.
    Diseases of the colon and rectum, 2003, Volume: 46, Issue:11

    Topics: Aged; Aminolevulinic Acid; Anus Neoplasms; Buttocks; Female; Humans; Paget Disease, Extramammary; Ph

2003
Cyclooxygenase-2 is a possible target of treatment approach in conjunction with photodynamic therapy for various disorders in skin and oral cavity.
    The British journal of dermatology, 2004, Volume: 151, Issue:2

    Topics: Aminolevulinic Acid; Bowen's Disease; Carcinoma, Squamous Cell; Cell Division; Cell Line, Tumor; Cyc

2004
Successful photodynamic therapy of vulval Paget's disease using a novel patch-based delivery system containing 5-aminolevulinic acid.
    BJOG : an international journal of obstetrics and gynaecology, 2004, Volume: 111, Issue:10

    Topics: Administration, Cutaneous; Aged; Aminolevulinic Acid; Female; Humans; Paget Disease, Extramammary; P

2004
5-Aminolevulinic acid-based photodynamic therapy for the treatment of two patients with extramammary Paget's disease.
    The Journal of dermatology, 2005, Volume: 32, Issue:2

    Topics: Aged; Aged, 80 and over; Aminolevulinic Acid; Female; Genital Neoplasms, Female; Genital Neoplasms,

2005
Photodynamic therapy for inoperable vulval Paget's disease using delta-aminolaevulinic acid: successful management of a large skin lesion.
    The British journal of dermatology, 1999, Volume: 141, Issue:2

    Topics: Aged; Aminolevulinic Acid; Female; Humans; Paget Disease, Extramammary; Photochemotherapy; Photosens

1999
Photodynamic therapy for the treatment of extramammary Paget's disease.
    The British journal of dermatology, 2002, Volume: 146, Issue:6

    Topics: Aged; Aminolevulinic Acid; Biopsy; Humans; Male; Middle Aged; Paget Disease, Extramammary; Photochem

2002