aminolevulinic acid has been researched along with Paget Disease, Extramammary in 36 studies
Aminolevulinic Acid: A compound produced from succinyl-CoA and GLYCINE as an intermediate in heme synthesis. It is used as a PHOTOCHEMOTHERAPY for actinic KERATOSIS.
5-aminolevulinic acid : The simplest delta-amino acid in which the hydrogens at the gamma position are replaced by an oxo group. It is metabolised to protoporphyrin IX, a photoactive compound which accumulates in the skin. Used (in the form of the hydrochloride salt)in combination with blue light illumination for the treatment of minimally to moderately thick actinic keratosis of the face or scalp.
Paget Disease, Extramammary: A rare cutaneous neoplasm that occurs in the elderly. It develops more frequently in women and predominantly involves apocrine gland-bearing areas, especially the vulva, scrotum, and perianal areas. The lesions develop as erythematous scaly patches that progress to crusted, pruritic, erythematous plaques. The clinical differential diagnosis includes squamous cell carcinoma in situ and superficial fungal infection. It is generally thought to be an adenocarcinoma of the epidermis, from which it extends into the contiguous epithelium of hair follicles and eccrine sweat ducts. (DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p1478)
| Excerpt | Relevance | Reference |
|---|---|---|
| " All patients were able to complete the treatment protocol, with well cosmetic results and no moderate adverse reactions." | 2.80 | Efficacy and safety of topical ALA-PDT in the treatment of EMPD. ( Fan, DL; Gao, Y; Lu, YG; Wang, HL; Wang, WS; Yang, Y; Zhang, XC, 2015) |
| "We present one case of vulvar extramammary Paget's disease (EMPD), that is a female patient with lesions in the vulva and involving the urethra." | 1.91 | Efficacy of hematoporphyrin injection (HpD) photodynamic therapy in the treatment of widespread extramammary Paget's disease. ( Li, Y; Liu, R; Liu, X; Ma, G; Ma, T; Tang, Y; Xiang, X, 2023) |
| " The purpose of this study was to illustrate the efficiency and safety of PDD-guided tumor excision combined with ALA-PDT in patients with extramammary Paget's disease (EMPD)." | 1.72 | PDD-guided tumor excision combined with photodynamic therapy in patients with extramammary Paget's disease. ( Kou, H; Li, X; Lu, Y; Yang, Y; Zhao, C; Zhu, F, 2022) |
| "In our study, 7 cases of EMPD were treated with PDD-guided tumor excision combined with ALA-PDT." | 1.72 | PDD-guided tumor excision combined with photodynamic therapy in patients with extramammary Paget's disease. ( Kou, H; Li, X; Lu, Y; Yang, Y; Zhao, C; Zhu, F, 2022) |
| "To evaluate the value of Wood's lamp examination combined with 5-aminolevulinic acid (5-ALA) photodynamic therapy (PDT) to determine positive tumor margins in patients with extramammary Paget's disease (EMPD) before surgery." | 1.62 | The application of Wood's lamp combined with 5-aminolevulinic acid for defining tumor margins in patients with extramammary Paget's disease. ( Fu, B; Li, J; Lou, Y; Song, C; Zhou, P, 2021) |
| " In the 5-ALA-PDT group, Wood's lamp examination combined with 5-ALA-PDT was used to trace the fluorescence range, and multipoint biopsy was performed according to the pathology to determine the final excision scope." | 1.62 | The application of Wood's lamp combined with 5-aminolevulinic acid for defining tumor margins in patients with extramammary Paget's disease. ( Fu, B; Li, J; Lou, Y; Song, C; Zhou, P, 2021) |
| "Wood's lamp examination combined with 5-ALA-PDT may predict tumor margins in EMPD." | 1.62 | The application of Wood's lamp combined with 5-aminolevulinic acid for defining tumor margins in patients with extramammary Paget's disease. ( Fu, B; Li, J; Lou, Y; Song, C; Zhou, P, 2021) |
| "To investigate the safety and efficacy of wide local excision combined with aminolevulinic acid (ALA) photodynamic therapy (PDT) for the treatment of scrotal Paget's disease in patients of advanced age." | 1.56 | Excision combined with photodynamic therapy for scrotal Paget's disease in patients aged over 60 years. ( Chen, M; Chen, X; Dai, Y; Li, D; Yang, Z; Zhang, X, 2020) |
| "44 years) with scrotal Paget's disease treated with wide local excision combined with ALA PDT and followed up from June 2014 to February 2018." | 1.56 | Excision combined with photodynamic therapy for scrotal Paget's disease in patients aged over 60 years. ( Chen, M; Chen, X; Dai, Y; Li, D; Yang, Z; Zhang, X, 2020) |
| "Wide local excision combined with ALA PDT shows good clinical efficacy and a low complication rate in patients of advanced age with scrotal Paget's disease." | 1.56 | Excision combined with photodynamic therapy for scrotal Paget's disease in patients aged over 60 years. ( Chen, M; Chen, X; Dai, Y; Li, D; Yang, Z; Zhang, X, 2020) |
| "Initial surgical margins were determined by FD or FD plus MSB." | 1.48 | Clinical Benefits of Preoperative Conventional Fluorescence Diagnosis in Surgical Treatment of Extramammary Paget Disease. ( Chen, Z; Ma, H; Wan, M; Xie, L; Zhao, Y, 2018) |
| "In conclusion, photodynamic therapy for extramammary Paget's disease is not recommended as the first option except for scrotal cases or lesions < 4 cm in diameter." | 1.36 | Long-term follow-up of in situ extramammary Paget's disease in Asian skin types IV/V treated with photodynamic therapy. ( Gao, T; Hu, X; Jiao, B; Li, C; Li, Q; Liao, W; Long, HA; Lv, Y; Qi, X; Qiao, H; Wang, L; Wang, S, 2010) |
| "We evaluated the clinical response, recurrence and adverse events of photodynamic therapy for in situ extramammary Paget's disease in 14 male and 3 female Chinese patients with 21 lesions." | 1.36 | Long-term follow-up of in situ extramammary Paget's disease in Asian skin types IV/V treated with photodynamic therapy. ( Gao, T; Hu, X; Jiao, B; Li, C; Li, Q; Liao, W; Long, HA; Lv, Y; Qi, X; Qiao, H; Wang, L; Wang, S, 2010) |
| "In the present study, five patients with extramammary Paget's disease with a total of eight lesions first underwent carbon dioxide (CO2) laser abrasion, followed by 3 h of occlusive application of aminolaevulinic acid (ALA) and then 100 J/cm2 irradiation with a 630-nm excimer dye laser." | 1.35 | Photodynamic therapy following carbon dioxide laser enhances efficacy in the treatment of extramammary Paget's disease. ( Fukui, T; Matsumoto, Y; Tamada, Y; Watanabe, D, 2009) |
| "They included squamous cell carcinoma (SCC), basal cell carcinoma (BCC), Bowen's disease (BD), mammary and extramammary Paget disease, actinic keratosis (AK) and erythroplasia of Queyrat." | 1.35 | Treatment of skin cancer and pre-cancer using topical ALA-PDT--a single hospital experience. ( Guo, MX; Wang, HW; Wang, XL; Xu, SZ, 2008) |
| "So far, we have treated 76 cases of skin cancer and pre-cancer using topical ALA-PDT." | 1.35 | Treatment of skin cancer and pre-cancer using topical ALA-PDT--a single hospital experience. ( Guo, MX; Wang, HW; Wang, XL; Xu, SZ, 2008) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (2.78) | 18.2507 |
| 2000's | 9 (25.00) | 29.6817 |
| 2010's | 20 (55.56) | 24.3611 |
| 2020's | 6 (16.67) | 2.80 |
| Authors | Studies |
|---|---|
| Li, X | 2 |
| Zhao, C | 1 |
| Kou, H | 1 |
| Zhu, F | 1 |
| Yang, Y | 2 |
| Lu, Y | 1 |
| Sachdeva, M | 1 |
| Tai, F | 1 |
| Bargman, H | 1 |
| Xiang, X | 1 |
| Li, Y | 1 |
| Tang, Y | 1 |
| Liu, R | 1 |
| Ma, T | 1 |
| Liu, X | 1 |
| Ma, G | 1 |
| Shim, PJ | 1 |
| Zeitouni, NC | 4 |
| Zhou, P | 1 |
| Li, J | 1 |
| Song, C | 1 |
| Lou, Y | 1 |
| Fu, B | 1 |
| Wan, M | 1 |
| Ma, H | 1 |
| Zhao, Y | 1 |
| Xie, L | 1 |
| Chen, Z | 1 |
| Peng, X | 1 |
| Qian, W | 1 |
| Hou, J | 1 |
| Theresia, C | 1 |
| Zheng, J | 1 |
| Chen, XY | 1 |
| Bauman, TM | 1 |
| Rosman, IS | 1 |
| Sheinbein, DM | 1 |
| Shen, S | 1 |
| Zhang, G | 2 |
| Wang, P | 2 |
| Zhang, Y | 2 |
| Keyal, U | 1 |
| Ji, J | 1 |
| Wang, X | 2 |
| Rioli, DI | 1 |
| Samimi, M | 1 |
| Beneton, N | 1 |
| Hainaut, E | 1 |
| Martin, L | 1 |
| Misery, L | 1 |
| Quereux, G | 1 |
| Chen, M | 1 |
| Chen, X | 1 |
| Dai, Y | 1 |
| Yang, Z | 1 |
| Zhang, X | 1 |
| Li, D | 1 |
| Li, C | 2 |
| Guo, L | 1 |
| Shi, L | 1 |
| Sun, X | 1 |
| Hu, C | 1 |
| Zhang, L | 2 |
| Fontanelli, R | 2 |
| Papadia, A | 1 |
| Martinelli, F | 1 |
| Lorusso, D | 1 |
| Grijuela, B | 1 |
| Merola, M | 1 |
| Solima, E | 2 |
| Ditto, A | 2 |
| Raspagliesi, F | 2 |
| Wang, HW | 2 |
| Lv, T | 1 |
| Zhang, LL | 1 |
| Lai, YX | 1 |
| Tang, L | 1 |
| Tang, YC | 1 |
| Huang, Z | 2 |
| Wang, XL | 2 |
| Jing, W | 1 |
| Juan, X | 1 |
| Jiayuan, C | 1 |
| Qin, H | 1 |
| Qing, L | 1 |
| Shengmei, X | 1 |
| Gao, Y | 1 |
| Zhang, XC | 1 |
| Wang, WS | 1 |
| Wang, HL | 1 |
| Lu, YG | 1 |
| Fan, DL | 1 |
| Youssef, AA | 1 |
| Reygagne, P | 1 |
| Vicentini, C | 1 |
| Carpentier, O | 1 |
| Lecomte, F | 1 |
| Thecua, E | 1 |
| Mortier, L | 1 |
| Mordon, SR | 1 |
| Li, L | 1 |
| Deng, Y | 1 |
| Liao, W | 2 |
| Luo, R | 1 |
| Fukui, T | 1 |
| Watanabe, D | 2 |
| Tamada, Y | 3 |
| Matsumoto, Y | 3 |
| Guo, MX | 1 |
| Xu, SZ | 1 |
| Li, Q | 1 |
| Gao, T | 1 |
| Jiao, B | 1 |
| Qi, X | 1 |
| Long, HA | 1 |
| Qiao, H | 1 |
| Wang, L | 1 |
| Lv, Y | 1 |
| Hu, X | 1 |
| Wang, S | 1 |
| Housel, JP | 1 |
| Izikson, L | 1 |
| Cherpelis, BS | 1 |
| Kitagawa, KH | 1 |
| Bogner, P | 1 |
| Kriz, M | 1 |
| Hegyi, J | 1 |
| Ruzicka, T | 1 |
| Berking, C | 1 |
| Al Yousef, A | 1 |
| Boccara, O | 1 |
| Moyal-Barracco, M | 1 |
| Zimmermann, U | 1 |
| Saiag, P | 1 |
| Longo-Imedio, MI | 1 |
| Araki, Y | 1 |
| Noake, T | 1 |
| Hata, H | 1 |
| Momosaki, K | 1 |
| Shirouzu, K | 1 |
| Akita, Y | 1 |
| Kozaki, K | 1 |
| Nakagawa, A | 1 |
| Saito, T | 1 |
| Ito, S | 1 |
| Fujiwara, S | 1 |
| Nishikawa, N | 1 |
| Uchida, K | 1 |
| Yoshikawa, K | 1 |
| Noguchi, T | 1 |
| Miyaishi, O | 1 |
| Shimozato, K | 1 |
| Saga, S | 1 |
| Zawislak, AA | 1 |
| McCarron, PA | 1 |
| McCluggage, WG | 1 |
| Price, JH | 1 |
| Donnelly, RF | 1 |
| McClelland, HR | 1 |
| Dobbs, SP | 1 |
| Woolfson, AD | 1 |
| Mikasa, K | 1 |
| Kondo, C | 1 |
| Kobayashi, M | 2 |
| Nakaseko, H | 1 |
| Yokoo, K | 1 |
| Rossi, G | 1 |
| Hanozet, F | 1 |
| Kusamura, S | 1 |
| Henta, T | 1 |
| Itoh, Y | 1 |
| Ninomiya, Y | 1 |
| Ishibashi, A | 1 |
| Shieh, S | 1 |
| Dee, AS | 1 |
| Cheney, RT | 1 |
| Frawley, NP | 1 |
| Oseroff, AR | 1 |
3 reviews available for aminolevulinic acid and Paget Disease, Extramammary
| Article | Year |
|---|---|
Treatment Outcomes of Adjunct and Stand-alone Photodynamic Therapy in Patients With Extramammary Paget Disease: A Literature Review.
Topics: Aminolevulinic Acid; Humans; Imiquimod; Paget Disease, Extramammary; Photochemotherapy; Photosensiti | 2023 |
Photodynamic therapy for extramammary Paget's disease: A systematic review of the literature.
Topics: Aminolevulinic Acid; Dihematoporphyrin Ether; Humans; Paget Disease, Extramammary; Photochemotherapy | 2020 |
Topical ALA-PDT as alternative therapeutic option in treatment-recalcitrant dermatosis: Report of 4 cases.
Topics: Acne Vulgaris; Adolescent; Adult; Aged, 80 and over; Aminolevulinic Acid; Condylomata Acuminata; Fem | 2017 |
4 trials available for aminolevulinic acid and Paget Disease, Extramammary
| Article | Year |
|---|---|
Photodynamic therapy with M-ALA as non surgical treatment option in patients with primary extramammary Paget's disease.
Topics: Aged; Aged, 80 and over; Aminolevulinic Acid; Female; Humans; Middle Aged; Paget Disease, Extramamma | 2013 |
A prospective pilot study to evaluate combined topical photodynamic therapy and surgery for extramammary paget's disease.
Topics: Administration, Topical; Aged; Aged, 80 and over; Aminolevulinic Acid; Cohort Studies; Combined Moda | 2013 |
Efficacy and safety of topical ALA-PDT in the treatment of EMPD.
Topics: Administration, Cutaneous; Aged; Aged, 80 and over; Aminolevulinic Acid; Combined Modality Therapy; | 2015 |
Photodynamic therapy using a methyl ester of 5-aminolevulinic acid in recurrent Paget's disease of the vulva: a pilot study.
Topics: Aged; Aminolevulinic Acid; Female; Humans; Middle Aged; Neoplasm Recurrence, Local; Paget Disease, E | 2006 |
29 other studies available for aminolevulinic acid and Paget Disease, Extramammary
| Article | Year |
|---|---|
PDD-guided tumor excision combined with photodynamic therapy in patients with extramammary Paget's disease.
Topics: Aminolevulinic Acid; Humans; Margins of Excision; Paget Disease, Extramammary; Photochemotherapy; Ph | 2022 |
Efficacy of hematoporphyrin injection (HpD) photodynamic therapy in the treatment of widespread extramammary Paget's disease.
Topics: Aminolevulinic Acid; Female; Hematoporphyrin Derivative; Hematoporphyrins; Humans; Paget Disease, Ex | 2023 |
The application of Wood's lamp combined with 5-aminolevulinic acid for defining tumor margins in patients with extramammary Paget's disease.
Topics: Aminolevulinic Acid; Humans; Margins of Excision; Neoplasm Recurrence, Local; Paget Disease, Extrama | 2021 |
Clinical Benefits of Preoperative Conventional Fluorescence Diagnosis in Surgical Treatment of Extramammary Paget Disease.
Topics: Aged; Aged, 80 and over; Aminolevulinic Acid; Biopsy; Female; Fluorescence; Frozen Sections; Humans; | 2018 |
5-aminolevulinic acid (5-ALA) fluorescence-guided Mohs surgery resection of penile-scrotal extramammary Paget's disease.
Topics: Aged; Aminolevulinic Acid; Disease-Free Survival; Humans; Male; Margins of Excision; Mohs Surgery; O | 2017 |
Extramammary Paget's disease of the scrotum with complete response to imiquimod and photodynamic therapy.
Topics: Administration, Topical; Aged; Aminolevulinic Acid; Aminoquinolines; Antineoplastic Agents; Biopsy; | 2018 |
ALA-PDT as palliative care in a patient with secondary perineum EMPD.
Topics: Aged; Aminolevulinic Acid; Humans; Male; Paget Disease, Extramammary; Palliative Care; Photochemothe | 2018 |
Efficacy and tolerance of photodynamic therapy for vulvar Paget's disease: a multicentric retrospective study.
Topics: Aged; Aged, 80 and over; Aminolevulinic Acid; Female; Follow-Up Studies; Humans; Middle Aged; Neopla | 2018 |
Excision combined with photodynamic therapy for scrotal Paget's disease in patients aged over 60 years.
Topics: Aged; Aminolevulinic Acid; Humans; Male; Paget Disease, Extramammary; Photochemotherapy; Scrotum; Tr | 2020 |
ALA-PDT combined with holmium laser therapy of postoperative recurrent extramammary Paget's disease.
Topics: Aged; Aminolevulinic Acid; Combined Modality Therapy; Humans; Lasers, Solid-State; Low-Level Light T | 2019 |
Complete remission of two patients with recurrent and wide spread extramammary Paget disease obtained from 5-aminolevulinic acid-based photodynamic therapy and imiquimod combination treatment.
Topics: Aged; Aminolevulinic Acid; Aminoquinolines; Antineoplastic Agents; Drug Therapy, Combination; Genita | 2014 |
Successful treatment of extramammary Paget's disease of the scalp with photodynamic therapy.
Topics: Aged, 80 and over; Aminolevulinic Acid; Head and Neck Neoplasms; Humans; Male; Paget Disease, Extram | 2016 |
Treatment of a vulvar Paget's disease by photodynamic therapy with a new light emitting fabric based device.
Topics: Aminolevulinic Acid; Female; Humans; Middle Aged; Paget Disease, Extramammary; Photochemotherapy; Ph | 2017 |
Treatment of perianal Paget's disease using photodynamic therapy with assistance of fluorescence examination: case report.
Topics: Aged; Aminolevulinic Acid; Anus Neoplasms; Female; Fluorescence; Humans; Laser Therapy; Paget Diseas | 2009 |
Photodynamic therapy following carbon dioxide laser enhances efficacy in the treatment of extramammary Paget's disease.
Topics: Aged; Aged, 80 and over; Aminolevulinic Acid; Combined Modality Therapy; Female; Humans; Lasers, Exc | 2009 |
Treatment of skin cancer and pre-cancer using topical ALA-PDT--a single hospital experience.
Topics: Administration, Topical; Adult; Aged; Aminolevulinic Acid; Carcinoma, Basal Cell; Carcinoma, Squamou | 2008 |
Long-term follow-up of in situ extramammary Paget's disease in Asian skin types IV/V treated with photodynamic therapy.
Topics: Administration, Cutaneous; Aged; Aged, 80 and over; Aminolevulinic Acid; Asian People; Carcinoma in | 2010 |
Noninvasive extramammary Paget's disease treated with photodynamic therapy: case series from the Roswell Park Cancer Institute.
Topics: Administration, Topical; Aged; Aged, 80 and over; Aminolevulinic Acid; Dihematoporphyrin Ether; Fema | 2010 |
Shining the light on photodynamic therapy in the treatment of extramammary Paget's disease.
Topics: Aminolevulinic Acid; Dihematoporphyrin Ether; Humans; Paget Disease, Extramammary; Photochemotherapy | 2010 |
Photodynamic therapy with methyl-aminolevulinate for the treatment of double extramammary Paget's disease.
Topics: Aged; Aminolevulinic Acid; Axilla; Humans; Male; Paget Disease, Extramammary; Photochemotherapy; Pho | 2011 |
Fluorescence diagnostics as a guide for demarcation and biopsy of suspected anal cancer.
Topics: Aged; Aminolevulinic Acid; Anus Neoplasms; Biopsy; Carcinoma; Eczema; Female; Fluorescence; Humans; | 2012 |
Incomplete efficacy of 5-aminolevulinic acid (5 ALA) photodynamic therapy in the treatment of widespread extramammary Paget's disease.
Topics: Aged; Aminolevulinic Acid; Female; Genital Diseases, Male; Humans; Male; Paget Disease, Extramammary | 2012 |
Letter: Photodynamic therapy with methyl-aminolevulinate for the treatment of double extramammary Paget's disease.
Topics: Aminolevulinic Acid; Humans; Male; Paget Disease, Extramammary; Photochemotherapy; Photosensitizing | 2013 |
Perianal Paget's disease treated with a wide excision and gluteal fold flap reconstruction guided by photodynamic diagnosis: report of a case.
Topics: Aged; Aminolevulinic Acid; Anus Neoplasms; Buttocks; Female; Humans; Paget Disease, Extramammary; Ph | 2003 |
Cyclooxygenase-2 is a possible target of treatment approach in conjunction with photodynamic therapy for various disorders in skin and oral cavity.
Topics: Aminolevulinic Acid; Bowen's Disease; Carcinoma, Squamous Cell; Cell Division; Cell Line, Tumor; Cyc | 2004 |
Successful photodynamic therapy of vulval Paget's disease using a novel patch-based delivery system containing 5-aminolevulinic acid.
Topics: Administration, Cutaneous; Aged; Aminolevulinic Acid; Female; Humans; Paget Disease, Extramammary; P | 2004 |
5-Aminolevulinic acid-based photodynamic therapy for the treatment of two patients with extramammary Paget's disease.
Topics: Aged; Aged, 80 and over; Aminolevulinic Acid; Female; Genital Neoplasms, Female; Genital Neoplasms, | 2005 |
Photodynamic therapy for inoperable vulval Paget's disease using delta-aminolaevulinic acid: successful management of a large skin lesion.
Topics: Aged; Aminolevulinic Acid; Female; Humans; Paget Disease, Extramammary; Photochemotherapy; Photosens | 1999 |
Photodynamic therapy for the treatment of extramammary Paget's disease.
Topics: Aged; Aminolevulinic Acid; Biopsy; Humans; Male; Middle Aged; Paget Disease, Extramammary; Photochem | 2002 |