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aminolevulinic acid and Osteogenic Sarcoma

aminolevulinic acid has been researched along with Osteogenic Sarcoma in 8 studies

Aminolevulinic Acid: A compound produced from succinyl-CoA and GLYCINE as an intermediate in heme synthesis. It is used as a PHOTOCHEMOTHERAPY for actinic KERATOSIS.
5-aminolevulinic acid : The simplest delta-amino acid in which the hydrogens at the gamma position are replaced by an oxo group. It is metabolised to protoporphyrin IX, a photoactive compound which accumulates in the skin. Used (in the form of the hydrochloride salt)in combination with blue light illumination for the treatment of minimally to moderately thick actinic keratosis of the face or scalp.

Research Excerpts

ExcerptRelevanceReference
"The aim of this study was to test the efficacy of aminolevulinic acid-mediated photodynamic therapy (PDT) against the human osteosarcoma cell line MG-63."7.83Aminolevulinic Acid-Mediated Photodynamic Therapy Causes Cell Death in MG-63 Human Osteosarcoma Cells. ( Baugher, PJ; Rossi, V; White, B, 2016)
"We investigated the killing effect of low-intensity ultrasound combined with 5-aminolevulinic acid (5-ALA) on the rat osteosarcoma cell line UMR-106."7.81Mechanism of rat osteosarcoma cell apoptosis induced by a combination of low-intensity ultrasound and 5-aminolevulinic acid in vitro. ( Cao, WW; Hu, Z; Li, QS; Li, YN; Wang, JH; Yang, B; Zhou, Q, 2015)
"We observed that two osteosarcoma cell lines from the same tumor displayed marked differences in their sensitivities to photodynamic therapy (PDT) with aminolevulinic acid hexyl ester (hALA-PDT)."7.75Synergistic increase in osteosarcoma cell sensitivity to photodynamic therapy with aminolevulinic acid hexyl ester in the presence of hyperthermia. ( Matsumura, Y; Nomura, J; Tagawa, T; Watanabe, Y; Yanase, S, 2009)
"Flow cytometry was used to evaluate the intracellular accumulation of protoporphyrin IX (PpIX), a metabolic product of aminolevulinic acid, in two human mandibular osteosarcoma cell lines (HOSM-1 and HOSM-2) treated with HT, hALA-PDT, or hALA-PDT combined with HT (PDT + HT)."7.75Synergistic increase in osteosarcoma cell sensitivity to photodynamic therapy with aminolevulinic acid hexyl ester in the presence of hyperthermia. ( Matsumura, Y; Nomura, J; Tagawa, T; Watanabe, Y; Yanase, S, 2009)
"In this study, the effectiveness and mechanism of combination therapy of 5-aminolevulinic acid-based photodynamic therapy (ALA-PDT) with simultaneous hyperthermia (HT) on human-derived osteosarcoma in vivo were examined."7.73Synergistic interaction of 5-aminolevulinic acid-based photodynamic therapy with simultaneous hyperthermia in an osteosarcoma tumor model. ( Fujii, T; Matsumura, Y; Nagata, T; Nomura, J; Tagawa, T; Yanase, S, 2006)
"Osteosarcoma is the most common type of primary malignant bone tumor diagnosed in the United States among adolescents and children."5.43Aminolevulinic Acid-Mediated Photodynamic Therapy Causes Cell Death in MG-63 Human Osteosarcoma Cells. ( Baugher, PJ; Rossi, V; White, B, 2016)
"The aim of this study was to test the efficacy of aminolevulinic acid-mediated photodynamic therapy (PDT) against the human osteosarcoma cell line MG-63."3.83Aminolevulinic Acid-Mediated Photodynamic Therapy Causes Cell Death in MG-63 Human Osteosarcoma Cells. ( Baugher, PJ; Rossi, V; White, B, 2016)
"We investigated the killing effect of low-intensity ultrasound combined with 5-aminolevulinic acid (5-ALA) on the rat osteosarcoma cell line UMR-106."3.81Mechanism of rat osteosarcoma cell apoptosis induced by a combination of low-intensity ultrasound and 5-aminolevulinic acid in vitro. ( Cao, WW; Hu, Z; Li, QS; Li, YN; Wang, JH; Yang, B; Zhou, Q, 2015)
"We observed that two osteosarcoma cell lines from the same tumor displayed marked differences in their sensitivities to photodynamic therapy (PDT) with aminolevulinic acid hexyl ester (hALA-PDT)."3.75Synergistic increase in osteosarcoma cell sensitivity to photodynamic therapy with aminolevulinic acid hexyl ester in the presence of hyperthermia. ( Matsumura, Y; Nomura, J; Tagawa, T; Watanabe, Y; Yanase, S, 2009)
"Flow cytometry was used to evaluate the intracellular accumulation of protoporphyrin IX (PpIX), a metabolic product of aminolevulinic acid, in two human mandibular osteosarcoma cell lines (HOSM-1 and HOSM-2) treated with HT, hALA-PDT, or hALA-PDT combined with HT (PDT + HT)."3.75Synergistic increase in osteosarcoma cell sensitivity to photodynamic therapy with aminolevulinic acid hexyl ester in the presence of hyperthermia. ( Matsumura, Y; Nomura, J; Tagawa, T; Watanabe, Y; Yanase, S, 2009)
"In the present study, we have investigated a combination of photodynamic therapy (PDT) using 5-aminolevulinic acid (ALA) and simultaneous hyperthermia (HT) on osteosarcoma (HOSM-1) cells, squamous cell carcinoma (KB) cells and fibroblasts (HF), including an assessment of the differences in the sensitivity of these cells to such treatment in vitro."3.73Enhancement of the effect of 5-aminolevulinic acid-based photodynamic therapy by simultaneous hyperthermia. ( Kinoshita, M; Matsumura, Y; Nagai, K; Nakanishi, H; Nomura, J; Ohnishi, Y; Tagawa, T; Tokuda, T; Yanase, S, 2005)
"In this study, the effectiveness and mechanism of combination therapy of 5-aminolevulinic acid-based photodynamic therapy (ALA-PDT) with simultaneous hyperthermia (HT) on human-derived osteosarcoma in vivo were examined."3.73Synergistic interaction of 5-aminolevulinic acid-based photodynamic therapy with simultaneous hyperthermia in an osteosarcoma tumor model. ( Fujii, T; Matsumura, Y; Nagata, T; Nomura, J; Tagawa, T; Yanase, S, 2006)
"Osteosarcoma is insensitive to radiation."1.62Using a Hybrid Radioenhancer to Discover Tumor Cell-targeted Treatment for Osteosarcoma: An In Vitro Study. ( Chen, LC; Chen, MH; Liu, TY; Shueng, PW; Tung, FI; Wang, YC, 2021)
"Osteosarcoma is the most common type of primary malignant bone tumor diagnosed in the United States among adolescents and children."1.43Aminolevulinic Acid-Mediated Photodynamic Therapy Causes Cell Death in MG-63 Human Osteosarcoma Cells. ( Baugher, PJ; Rossi, V; White, B, 2016)

Research

Studies (8)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's3 (37.50)29.6817
2010's4 (50.00)24.3611
2020's1 (12.50)2.80

Authors

AuthorsStudies
Tung, FI1
Chen, LC1
Wang, YC1
Chen, MH1
Shueng, PW1
Liu, TY1
Li, Y1
Zhou, Q2
Hu, Z2
Yang, B2
Li, Q1
Wang, J1
Zheng, J1
Cao, W1
Li, YN1
Wang, JH1
Li, QS1
Cao, WW1
White, B1
Rossi, V1
Baugher, PJ1
Yanase, S3
Nomura, J3
Matsumura, Y3
Watanabe, Y1
Tagawa, T3
Coupienne, I1
Fettweis, G1
Piette, J1
Nagai, K1
Kinoshita, M1
Nakanishi, H1
Ohnishi, Y1
Tokuda, T1
Nagata, T1
Fujii, T1

Other Studies

8 other studies available for aminolevulinic acid and Osteogenic Sarcoma

ArticleYear
Using a Hybrid Radioenhancer to Discover Tumor Cell-targeted Treatment for Osteosarcoma: An In Vitro Study.
    Current medicinal chemistry, 2021, Volume: 28, Issue:19

    Topics: Aminolevulinic Acid; Apoptosis; Cell Line, Tumor; Cell Survival; Humans; Osteosarcoma; Reactive Oxyg

2021
5-Aminolevulinic Acid-Based Sonodynamic Therapy Induces the Apoptosis of Osteosarcoma in Mice.
    PloS one, 2015, Volume: 10, Issue:7

    Topics: Aminolevulinic Acid; Animals; Apoptosis; Cell Line, Tumor; Cell Proliferation; Immunohistochemistry;

2015
Mechanism of rat osteosarcoma cell apoptosis induced by a combination of low-intensity ultrasound and 5-aminolevulinic acid in vitro.
    Genetics and molecular research : GMR, 2015, Aug-14, Volume: 14, Issue:3

    Topics: Aminolevulinic Acid; Apoptosis; Cell Line, Tumor; Flow Cytometry; Humans; Osteosarcoma; Reactive Oxy

2015
Aminolevulinic Acid-Mediated Photodynamic Therapy Causes Cell Death in MG-63 Human Osteosarcoma Cells.
    Photomedicine and laser surgery, 2016, Volume: 34, Issue:9

    Topics: Aminolevulinic Acid; Bone Neoplasms; Cell Death; Cell Line, Tumor; Cell Survival; Humans; Osteosarco

2016
Synergistic increase in osteosarcoma cell sensitivity to photodynamic therapy with aminolevulinic acid hexyl ester in the presence of hyperthermia.
    Photomedicine and laser surgery, 2009, Volume: 27, Issue:5

    Topics: Aminolevulinic Acid; Cell Line, Tumor; Combined Modality Therapy; Humans; Hyperthermia, Induced; Inf

2009
RIP3 expression induces a death profile change in U2OS osteosarcoma cells after 5-ALA-PDT.
    Lasers in surgery and medicine, 2011, Volume: 43, Issue:7

    Topics: Aminolevulinic Acid; Apoptosis; Autophagy; Blotting, Western; Bone Neoplasms; Cell Line, Tumor; Cell

2011
Enhancement of the effect of 5-aminolevulinic acid-based photodynamic therapy by simultaneous hyperthermia.
    International journal of oncology, 2005, Volume: 27, Issue:1

    Topics: Aminolevulinic Acid; Antineoplastic Agents; Blotting, Western; Cell Line, Tumor; Cell Separation; Ch

2005
Synergistic interaction of 5-aminolevulinic acid-based photodynamic therapy with simultaneous hyperthermia in an osteosarcoma tumor model.
    International journal of oncology, 2006, Volume: 29, Issue:2

    Topics: Aminolevulinic Acid; Animals; Antigens, Neoplasm; Carbonic Anhydrase IX; Carbonic Anhydrases; Cell L

2006