aminolevulinic acid has been researched along with Nervous System Diseases in 15 studies
Aminolevulinic Acid: A compound produced from succinyl-CoA and GLYCINE as an intermediate in heme synthesis. It is used as a PHOTOCHEMOTHERAPY for actinic KERATOSIS.
5-aminolevulinic acid : The simplest delta-amino acid in which the hydrogens at the gamma position are replaced by an oxo group. It is metabolised to protoporphyrin IX, a photoactive compound which accumulates in the skin. Used (in the form of the hydrochloride salt)in combination with blue light illumination for the treatment of minimally to moderately thick actinic keratosis of the face or scalp.
Nervous System Diseases: Diseases of the central and peripheral nervous system. This includes disorders of the brain, spinal cord, cranial nerves, peripheral nerves, nerve roots, autonomic nervous system, neuromuscular junction, and muscle.
| Excerpt | Relevance | Reference |
|---|---|---|
| " A provisional diagnosis of acute intermittent porphyria was made and was confirmed by the increased levels of urinary delta-aminolevulinic acid (ALA) and porphobilinogen (PBG)." | 3.68 | Acute intermittent porphyria. A perplexing case. ( Arena, A; Russo, P; Scuderi, D, 1992) |
| "The non-acute porphyrias are porphyria cutanea tarda, erythropoietic protoporphyria, X-linked protoporphyria, and the rare congenital erythropoietic porphyria." | 2.61 | Clinical Guide and Update on Porphyrias. ( Doss, MO; Schuppan, D; Stölzel, U, 2019) |
| "Porphyrias are inherited and acquired diseases of erythroid or hepatic origin, in which there are defects in specific enzymes of the heme biosynthetic pathway." | 2.38 | Free radicals involvement in neurological porphyrias and lead poisoning. ( Abdalla, DS; Bechara, EJ; Monteiro, HP, 1991) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (20.00) | 18.7374 |
| 1990's | 5 (33.33) | 18.2507 |
| 2000's | 1 (6.67) | 29.6817 |
| 2010's | 6 (40.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Yasuda, M | 1 |
| Gan, L | 1 |
| Chen, B | 1 |
| Yu, C | 1 |
| Zhang, J | 1 |
| Gama-Sosa, MA | 1 |
| Pollak, DD | 1 |
| Berger, S | 1 |
| Phillips, JD | 1 |
| Edelmann, W | 1 |
| Desnick, RJ | 1 |
| Stölzel, U | 1 |
| Doss, MO | 1 |
| Schuppan, D | 1 |
| Hickmann, AK | 1 |
| Nadji-Ohl, M | 1 |
| Hopf, NJ | 1 |
| Stummer, W | 1 |
| Tonn, JC | 1 |
| Mehdorn, HM | 1 |
| Nestler, U | 1 |
| Franz, K | 1 |
| Goetz, C | 1 |
| Bink, A | 1 |
| Pichlmeier, U | 1 |
| Kuo, HC | 1 |
| Huang, CC | 1 |
| Chu, CC | 1 |
| Lee, MJ | 1 |
| Chuang, WL | 1 |
| Wu, CL | 1 |
| Wu, T | 1 |
| Ning, HC | 1 |
| Liu, CY | 1 |
| Schucht, P | 1 |
| Beck, J | 1 |
| Abu-Isa, J | 1 |
| Andereggen, L | 1 |
| Murek, M | 1 |
| Seidel, K | 1 |
| Stieglitz, L | 1 |
| Raabe, A | 1 |
| Sylantiev, C | 1 |
| Schoenfeld, N | 1 |
| Mamet, R | 1 |
| Groozman, GB | 1 |
| Drory, VE | 1 |
| Silbergeld, EK | 1 |
| Lamon, JM | 1 |
| McColl, KE | 1 |
| Goldberg, A | 1 |
| Bonkowsky, HL | 1 |
| Schady, W | 1 |
| Helson, L | 1 |
| Braverman, S | 1 |
| Mangiardi, J | 1 |
| Lindberg, RL | 1 |
| Porcher, C | 1 |
| Grandchamp, B | 1 |
| Ledermann, B | 1 |
| Bürki, K | 1 |
| Brandner, S | 1 |
| Aguzzi, A | 1 |
| Meyer, UA | 1 |
| Apostoli, P | 1 |
| Arena, A | 1 |
| Russo, P | 1 |
| Scuderi, D | 1 |
| Monteiro, HP | 1 |
| Bechara, EJ | 1 |
| Abdalla, DS | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| 5-Aminolevulinic Acid (5-ALA) Gliolan®: Usage Increase Proposal for Neurosurgical Procedures in High-Grade Gliomas[NCT05850377] | 90 participants (Anticipated) | Observational | 2023-06-01 | Not yet recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
4 reviews available for aminolevulinic acid and Nervous System Diseases
| Article | Year |
|---|---|
Clinical Guide and Update on Porphyrias.
Topics: Aminolevulinic Acid; Gastroenterology; Gastrointestinal Diseases; Humans; Nervous System Diseases; P | 2019 |
Neurologic manifestations of acute porphyria.
Topics: Acute Disease; Aminolevulinic Acid; Animals; Central Nervous System; Depression; Electrophysiology; | 1982 |
[Update on the subject of lead toxicology].
Topics: Abnormalities, Drug-Induced; Aminolevulinic Acid; Animals; Biomarkers; Cardiovascular Diseases; Coho | 1998 |
Free radicals involvement in neurological porphyrias and lead poisoning.
Topics: Aminolevulinic Acid; Animals; Erythrocytes; Free Radicals; Glutathione Peroxidase; Humans; Lead Pois | 1991 |
1 trial available for aminolevulinic acid and Nervous System Diseases
| Article | Year |
|---|---|
Counterbalancing risks and gains from extended resections in malignant glioma surgery: a supplemental analysis from the randomized 5-aminolevulinic acid glioma resection study. Clinical article.
Topics: Adult; Aged; Aminolevulinic Acid; Anti-Inflammatory Agents; Brain Neoplasms; Consciousness Disorders | 2011 |
10 other studies available for aminolevulinic acid and Nervous System Diseases
| Article | Year |
|---|---|
Homozygous hydroxymethylbilane synthase knock-in mice provide pathogenic insights into the severe neurological impairments present in human homozygous dominant acute intermittent porphyria.
Topics: Aminolevulinic Acid; Animals; Central Nervous System; Gene Knock-In Techniques; Genes, Dominant; Hom | 2019 |
Feasibility of fluorescence-guided resection of recurrent gliomas using five-aminolevulinic acid: retrospective analysis of surgical and neurological outcome in 58 patients.
Topics: Adult; Aged; Aminolevulinic Acid; Brain Neoplasms; Case-Control Studies; Feasibility Studies; Female | 2015 |
Neurological complications of acute intermittent porphyria.
Topics: Adolescent; Adult; Aminolevulinic Acid; Brain; Electroencephalography; Electromyography; Female; Hum | 2011 |
Gross total resection rates in contemporary glioblastoma surgery: results of an institutional protocol combining 5-aminolevulinic acid intraoperative fluorescence imaging and brain mapping.
Topics: Adult; Aged; Aged, 80 and over; Aminolevulinic Acid; Brain Mapping; Brain Neoplasms; Electroencephal | 2012 |
Acute neuropathy mimicking porphyria induced by aminolevulinic acid during photodynamic therapy.
Topics: Acute Disease; Aged; Aged, 80 and over; Aminolevulinic Acid; Barrett Esophagus; Diagnosis, Different | 2005 |
Role of altered heme synthesis in lead neurotoxicity.
Topics: Aminolevulinic Acid; gamma-Aminobutyric Acid; Heme; Humans; Lead Poisoning; Nervous System Diseases; | 1980 |
The biochemical basis of the acute porphyrias.
Topics: Acute Disease; Aminolevulinic Acid; Heme; Humans; Nervous System Diseases; Porphyrias; Porphyrins | 1983 |
delta-Aminolevulinic acid effects on neuronal and glial tumor cell lines.
Topics: Aminolevulinic Acid; Cell Survival; Deferoxamine; Glioblastoma; Hemin; Humans; Nervous System Diseas | 1993 |
Porphobilinogen deaminase deficiency in mice causes a neuropathy resembling that of human hepatic porphyria.
Topics: Aminolevulinic Acid; Animals; Atrophy; Axons; Base Sequence; Chimera; Disease Models, Animal; Female | 1996 |
Acute intermittent porphyria. A perplexing case.
Topics: Acute Disease; Aminolevulinic Acid; Female; Humans; Middle Aged; Nervous System Diseases; Pain; Porp | 1992 |