aminolevulinic acid has been researched along with Nail Fungus in 14 studies
Aminolevulinic Acid: A compound produced from succinyl-CoA and GLYCINE as an intermediate in heme synthesis. It is used as a PHOTOCHEMOTHERAPY for actinic KERATOSIS.
5-aminolevulinic acid : The simplest delta-amino acid in which the hydrogens at the gamma position are replaced by an oxo group. It is metabolised to protoporphyrin IX, a photoactive compound which accumulates in the skin. Used (in the form of the hydrochloride salt)in combination with blue light illumination for the treatment of minimally to moderately thick actinic keratosis of the face or scalp.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To compare the efficacy of combined therapies based on oral terbinafine (TN) plus adjunctive PDT mediated by methylene blue (MB) (TN + MB/PDT) or methyl aminolevulinate (MAL) (TN + MAL/PDT) in the treatment of onychomycosis." | 7.96 | Methylene blue vs methyl aminolevulinate photodynamic therapy in combination with oral terbinafine in the treatment of severe dermatophytic toenail onychomycosis: Short- and long-term effects. ( Alberdi, E; Gómez, C, 2020) |
| " PDT of onychomycosis (n = 380 patients) found treatment with methylene blue (MB) photosensitizer (PS) more efficacious with complete cure rates of 70 %-80 % than 5-aminolevulinic acid (ALA)-PDT (mycological cure rates of 17 %-57 %) and methyl aminolevulinate (MAL)-PDT (mycological cure rate of 32 %)." | 5.05 | Photodynamic therapy treatment of superficial fungal infections: A systematic review. ( Arendrup, MC; Jemec, GBE; Saunte, DML; Shen, JJ, 2020) |
| "To compare the efficacy of combined therapies based on oral terbinafine (TN) plus adjunctive PDT mediated by methylene blue (MB) (TN + MB/PDT) or methyl aminolevulinate (MAL) (TN + MAL/PDT) in the treatment of onychomycosis." | 3.96 | Methylene blue vs methyl aminolevulinate photodynamic therapy in combination with oral terbinafine in the treatment of severe dermatophytic toenail onychomycosis: Short- and long-term effects. ( Alberdi, E; Gómez, C, 2020) |
| "In the present investigation, we have shown for the first time that the onychomycosis-inducing dermatophyte Trichophyton rubrum was able to metabolize 5-aminolevulinic acid (ALA) to protoporphyrin IX (PpIX) in liquid culture medium." | 3.73 | Antifungal effect of 5-aminolevulinic acid PDT in Trichophyton rubrum. ( Blume-Peytavi, U; Kamp, H; Lademann, J; Lutz, M; Piazena, H; Sowyrda, P; Tietz, HJ, 2005) |
| "Onychomycosis is a common fungal nail infection that responds poorly to antifungals." | 2.84 | Methyl aminolevulinate photodynamic therapy for onychomycosis: a multicentre, randomized, controlled clinical trial. ( Aspiroz, C; Frías, MP; García-Doval, I; Gilaberte, Y; Rezusta, A; Robres, MP, 2017) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (21.43) | 29.6817 |
| 2010's | 8 (57.14) | 24.3611 |
| 2020's | 3 (21.43) | 2.80 |
| Authors | Studies |
|---|---|
| Shen, JJ | 1 |
| Jemec, GBE | 1 |
| Arendrup, MC | 1 |
| Saunte, DML | 1 |
| Alberdi, E | 2 |
| Gómez, C | 2 |
| Koren, A | 1 |
| Salameh, F | 1 |
| Sprecher, E | 1 |
| Artzi, O | 1 |
| Aspiroz, C | 4 |
| Fortuño-Cebamanos, B | 1 |
| Rezusta, A | 4 |
| Gilaberte, Y | 4 |
| Robres, P | 1 |
| Haedersdal, M | 1 |
| Erlendsson, AM | 1 |
| Paasch, U | 1 |
| Anderson, RR | 1 |
| Robres, MP | 1 |
| Frías, MP | 1 |
| García-Doval, I | 1 |
| Braathen, LR | 1 |
| Piraccini, BM | 1 |
| Rech, G | 1 |
| Tosti, A | 1 |
| Sotiriou, E | 1 |
| Koussidou-Eremonti, T | 1 |
| Chaidemenos, G | 1 |
| Apalla, Z | 1 |
| Ioannides, D | 1 |
| Martes, MP | 1 |
| Alcalde, V | 1 |
| Espinel-Ingroff, A | 1 |
| Kamp, H | 1 |
| Tietz, HJ | 1 |
| Lutz, M | 1 |
| Piazena, H | 1 |
| Sowyrda, P | 1 |
| Lademann, J | 1 |
| Blume-Peytavi, U | 1 |
| Donnelly, RF | 1 |
| McCarron, PA | 1 |
| Lightowler, JM | 1 |
| Woolfson, AD | 1 |
3 reviews available for aminolevulinic acid and Nail Fungus
| Article | Year |
|---|---|
Photodynamic therapy treatment of superficial fungal infections: A systematic review.
Topics: Aminolevulinic Acid; Dermatomycoses; Humans; Methylene Blue; Onychomycosis; Photochemotherapy; Photo | 2020 |
Usefulness of Photodynamic Therapy in the Management of Onychomycosis.
Topics: Aminolevulinic Acid; Antifungal Agents; Clinical Protocols; Clinical Trials as Topic; Drug Administr | 2015 |
Translational medicine in the field of ablative fractional laser (AFXL)-assisted drug delivery: A critical review from basics to current clinical status.
Topics: Administration, Cutaneous; Aminolevulinic Acid; Anesthetics; Animals; Cicatrix; Controlled Clinical | 2016 |
4 trials available for aminolevulinic acid and Nail Fungus
| Article | Year |
|---|---|
Methylene blue vs methyl aminolevulinate photodynamic therapy in the treatment of mild-to-moderate toenail onychomycosis: Short- and medium-term effects.
Topics: Aminolevulinic Acid; Humans; Methylene Blue; Nails; Onychomycosis; Photochemotherapy; Photosensitizi | 2020 |
Laser-assisted Photodynamic Therapy or Laser-assisted Amorolfine Lacquer Delivery for Treatment of Toenail Onychomycosis: An Open-label Comparative Study.
Topics: Adult; Aged; Aminolevulinic Acid; Antifungal Agents; Female; Foot Dermatoses; Humans; Lacquer; Laser | 2018 |
Methyl aminolevulinate photodynamic therapy for onychomycosis: a multicentre, randomized, controlled clinical trial.
Topics: Aged; Aminolevulinic Acid; Female; Humans; Male; Middle Aged; Onychomycosis; Photochemotherapy; Phot | 2017 |
Photodynamic therapy for distal and lateral subungual toenail onychomycosis caused by Trichophyton rubrum: Preliminary results of a single-centre open trial.
Topics: Administration, Topical; Adult; Aged; Aged, 80 and over; Aminolevulinic Acid; Female; Foot Dermatose | 2010 |
7 other studies available for aminolevulinic acid and Nail Fungus
| Article | Year |
|---|---|
Methylene blue vs methyl aminolevulinate photodynamic therapy in combination with oral terbinafine in the treatment of severe dermatophytic toenail onychomycosis: Short- and long-term effects.
Topics: Aminolevulinic Acid; Antifungal Agents; Drug Combinations; Female; Foot Dermatoses; Humans; Male; Me | 2020 |
Photodynamic therapy with methyl-aminolevulinate can be useful in the management of Scytalidium infections.
Topics: Aminolevulinic Acid; Antifungal Agents; Aspergillosis; Coinfection; Combined Modality Therapy; Femal | 2013 |
PDT for onychomycosis.
Topics: Aminolevulinic Acid; Humans; Onychomycosis; Photochemotherapy; Photosensitizing Agents; Treatment Ou | 2017 |
Photodynamic therapy of onychomycosis caused by Trichophyton rubrum.
Topics: Aged; Aminolevulinic Acid; Female; Foot Dermatoses; Humans; Onychomycosis; Photochemotherapy; Tricho | 2008 |
Treatment of refractory fingernail onychomycosis caused by nondermatophyte molds with methylaminolevulinate photodynamic therapy.
Topics: Adult; Aminolevulinic Acid; Aspergillosis; Female; Fusarium; Hand Dermatoses; Humans; Middle Aged; O | 2011 |
Antifungal effect of 5-aminolevulinic acid PDT in Trichophyton rubrum.
Topics: Aminolevulinic Acid; Humans; Hydrogen-Ion Concentration; Microscopy, Fluorescence; Mycelium; Onychom | 2005 |
Bioadhesive patch-based delivery of 5-aminolevulinic acid to the nail for photodynamic therapy of onychomycosis.
Topics: Adhesives; Aminolevulinic Acid; Animals; Candida albicans; Hoof and Claw; Humans; In Vitro Technique | 2005 |