Page last updated: 2024-10-16

aminolevulinic acid and Meningioma

aminolevulinic acid has been researched along with Meningioma in 41 studies

Aminolevulinic Acid: A compound produced from succinyl-CoA and GLYCINE as an intermediate in heme synthesis. It is used as a PHOTOCHEMOTHERAPY for actinic KERATOSIS.
5-aminolevulinic acid : The simplest delta-amino acid in which the hydrogens at the gamma position are replaced by an oxo group. It is metabolised to protoporphyrin IX, a photoactive compound which accumulates in the skin. Used (in the form of the hydrochloride salt)in combination with blue light illumination for the treatment of minimally to moderately thick actinic keratosis of the face or scalp.

Meningioma: A relatively common neoplasm of the CENTRAL NERVOUS SYSTEM that arises from arachnoidal cells. The majority are well differentiated vascular tumors which grow slowly and have a low potential to be invasive, although malignant subtypes occur. Meningiomas have a predilection to arise from the parasagittal region, cerebral convexity, sphenoidal ridge, olfactory groove, and SPINAL CANAL. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, pp2056-7)

Research Excerpts

ExcerptRelevanceReference
"The usefulness of 5-aminolevulinic acid (5-ALA)-mediated fluorescence-guided surgery (FGS) in meningiomas is intensely discussed."7.96Real-time in vivo kinetics of protoporphyrin IX after administration of 5-aminolevulinic acid in meningiomas and comparative analyses with glioblastomas. ( Brokinkel, B; Bunk, EC; Hess, K; Holling, M; Kaneko, S; Paulus, W; Senner, V; Stummer, W; Suero Molina, E; Warneke, N, 2020)
"To compare fluorescence intensity of tumor specimens, as measured by a fluorescence-guided surgery microscope and a spectrometer, to evaluate tumor infiltration of dura mater around meningiomas with help of these 2 different 5-aminolevulinic acid (5-ALA)-based fluorescence tools, and to correlate fluorescence intensity with histopathologic data."7.85Fluorescence Behavior and Dural Infiltration of Meningioma Analyzed by 5-Aminolevulinic Acid-Based Fluorescence: Operating Microscope Versus Mini-Spectrometer. ( Beseoglu, K; Cornelius, JF; Felsberg, J; Fischer, I; Kamp, M; Knipps, J; Neumann, LM; Steiger, HJ, 2017)
"Ciprofloxacin and longer ALA incubation time significantly increased the lethal effect of 5-ALA PDT on meningioma cells."7.80Enhancing the effect of 5-aminolevulinic acid based photodynamic therapy in human meningioma cells. ( Cornelius, JF; El Khatib, M; Giannakis, A; Senger, B; Slotty, PJ; Steiger, HJ, 2014)
"To the best of our knowledge, this is the first case demonstrating the efficacy of PDD using 5-aminolevulinic acid for a meningioma with cranial invasion."7.74Usefulness of intraoperative photodynamic diagnosis using 5-aminolevulinic acid for meningiomas with cranial invasion: technical case report. ( Hayashi, Y; Matsuo, T; Morofuji, Y; Nagata, I; Suyama, K, 2008)
"We present a case of a meningioma in which photodynamic diagnosis (PDD) using 5-aminolevulinic acid was very useful in identifying the cranial involvement."7.74Usefulness of intraoperative photodynamic diagnosis using 5-aminolevulinic acid for meningiomas with cranial invasion: technical case report. ( Hayashi, Y; Matsuo, T; Morofuji, Y; Nagata, I; Suyama, K, 2008)
"Meningiomas have a 5 year recurrence rate of 8%."5.915-aminolevulinic acid fluorescence guided surgery for resection of cystic meningioma with bone invasion. ( Cabezudo Artero, JM; Fernández Portales, I; García Moreno, R; Hidalgo Llorca, M; Ippolito Bastidas, H; Rubio Fernández, A, 2023)
"The first case was a small olfactory groove meningioma resected via a trans-eyebrow, subfrontal approach."5.51Surgery of Small Anterior Skull Base Meningiomas by Endoscopic 5-Aminolevulinic Acid Fluorescence Guidance: First Clinical Experience. ( Beez, T; Cornelius, JF; Kamp, MA; Knipps, J; Krause-Molle, Z; Petridis, AK; Sabel, M; Schipper, J; Steiger, HJ; Tortora, A, 2019)
"As ciprofloxacin is a common antibiotic with good tissue penetration, low toxicity and a favorable risk profile it represents a clinically interesting method for future PDT trials in meningiomas."5.40Enhancing the effect of 5-aminolevulinic acid based photodynamic therapy in human meningioma cells. ( Cornelius, JF; El Khatib, M; Giannakis, A; Senger, B; Slotty, PJ; Steiger, HJ, 2014)
"Efficacy of 5-ALA PDT could be increased by adjunction of ciprofloxacin in conventional clinical dosing and by prolongation of ALA incubation time."5.40Enhancing the effect of 5-aminolevulinic acid based photodynamic therapy in human meningioma cells. ( Cornelius, JF; El Khatib, M; Giannakis, A; Senger, B; Slotty, PJ; Steiger, HJ, 2014)
"The patient harboring a sphenoid wing meningioma with intraorbital extension underwent radical resection of the tumor with both visibly and nonvisibly fluorescent regions."5.37Quantitative and qualitative 5-aminolevulinic acid-induced protoporphyrin IX fluorescence in skull base meningiomas. ( Bekelis, K; Erkmen, K; Harris, BT; Kim, A; Leblond, F; Paulsen, KD; Roberts, DW; Valdés, PA; Wilson, BC, 2011)
"OBJECTIVE The objective of this study was to detect 5-aminolevulinic acid (ALA)-induced tumor fluorescence from glioma below the surface of the surgical field by using red-light illumination."5.27Red-light excitation of protoporphyrin IX fluorescence for subsurface tumor detection. ( Bravo, JJ; Evans, LT; Fan, X; Kanick, SC; Kolste, KK; Leblond, F; Marois, M; Olson, JD; Paulsen, KD; Roberts, DW; Wilson, BC, 2018)
" Qualitative fluorescence of protoporphyrin IX (PpIX), synthesized endogenously following δ-aminolevulinic acid (ALA) administration, has been used for this purpose in high-grade glioma (HGG)."5.15Quantitative fluorescence in intracranial tumor: implications for ALA-induced PpIX as an intraoperative biomarker. ( Erkmen, K; Fan, X; Harris, BT; Hartov, A; Ji, S; Kim, A; Leblond, F; Paulsen, KD; Roberts, DW; Simmons, NE; Tosteson, TD; Valdés, PA; Wilson, BC, 2011)
"Conventionary, we use 5-aminolevulinic acid (5-ALA) for photo-dynamic diagnosis in the removal of malignant gliomas."4.85[Intraoperative photo-dynamic diagnosis of brain tumors]. ( Kajimoto, Y; Kuroiwa, T; Miyatake, S, 2009)
"Studies of novel microsurgical adjuncts, such as 5-aminolevulinic acid (5-ALA) fluorescence have shown various fluorescence patterns within meningiomas, opening new avenues for complete microsurgical resection."4.31Benefits of combined use of ( Jaillard, A; Peciu-Florianu, I; Reyns, N; Tuleasca, C, 2023)
"Although the utility 5-aminolevulinic acid (5-ALA)-mediated fluorescence-guided surgery (FGS) in meningiomas is increasingly discussed, data about the kinetics of protoporphyrin IX (PpIX) and tumor fluorescence are sparse."4.025-ALA kinetics in meningiomas: analysis of tumor fluorescence and PpIX metabolism in vitro and comparative analyses with high-grade gliomas. ( Brokinkel, B; Bunk, EC; Senner, V; Stummer, W; Wagner, A, 2021)
"The usefulness of 5-aminolevulinic acid (5-ALA)-mediated fluorescence-guided surgery (FGS) in meningiomas is intensely discussed."3.96Real-time in vivo kinetics of protoporphyrin IX after administration of 5-aminolevulinic acid in meningiomas and comparative analyses with glioblastomas. ( Brokinkel, B; Bunk, EC; Hess, K; Holling, M; Kaneko, S; Paulus, W; Senner, V; Stummer, W; Suero Molina, E; Warneke, N, 2020)
"To compare fluorescence intensity of tumor specimens, as measured by a fluorescence-guided surgery microscope and a spectrometer, to evaluate tumor infiltration of dura mater around meningiomas with help of these 2 different 5-aminolevulinic acid (5-ALA)-based fluorescence tools, and to correlate fluorescence intensity with histopathologic data."3.85Fluorescence Behavior and Dural Infiltration of Meningioma Analyzed by 5-Aminolevulinic Acid-Based Fluorescence: Operating Microscope Versus Mini-Spectrometer. ( Beseoglu, K; Cornelius, JF; Felsberg, J; Fischer, I; Kamp, M; Knipps, J; Neumann, LM; Steiger, HJ, 2017)
"Ciprofloxacin and longer ALA incubation time significantly increased the lethal effect of 5-ALA PDT on meningioma cells."3.80Enhancing the effect of 5-aminolevulinic acid based photodynamic therapy in human meningioma cells. ( Cornelius, JF; El Khatib, M; Giannakis, A; Senger, B; Slotty, PJ; Steiger, HJ, 2014)
"(PpIX) fluorescence induced by 5-aminolevulinic acid (5-ALA), which appears in various tumors including malignant gliomas, is a good navigator for tumor resection."3.79Experimental study to understand nonspecific protoporphyrin IX fluorescence in brain tissues near tumors after 5-aminolevulinic acid administration. ( Fujishiro, T; Kajimoto, Y; Kawabata, S; Kuroiwa, T; Masubuchi, T; Miyatake, S; Nonoguchi, N, 2013)
"Fluorescence-guided resection with 5-aminolevulinic acid (5-ALA), which has shown promising results in the resection of malignant gliomas, has been used for meningioma resection in an attempt to more clearly delineate the tumor margin."3.77Confocal microscopy for the histological fluorescence pattern of a recurrent atypical meningioma: case report. ( Harris, BT; Paulsen, KD; Roberts, DW; Valdes, PA; Whitson, WJ, 2011)
"We present a case of a meningioma in which photodynamic diagnosis (PDD) using 5-aminolevulinic acid was very useful in identifying the cranial involvement."3.74Usefulness of intraoperative photodynamic diagnosis using 5-aminolevulinic acid for meningiomas with cranial invasion: technical case report. ( Hayashi, Y; Matsuo, T; Morofuji, Y; Nagata, I; Suyama, K, 2008)
"To the best of our knowledge, this is the first case demonstrating the efficacy of PDD using 5-aminolevulinic acid for a meningioma with cranial invasion."3.74Usefulness of intraoperative photodynamic diagnosis using 5-aminolevulinic acid for meningiomas with cranial invasion: technical case report. ( Hayashi, Y; Matsuo, T; Morofuji, Y; Nagata, I; Suyama, K, 2008)
"Though meningiomas are often benign and well circumscribed in nature, many are associated with recurrences and poor outcome because of their attachment to neurovascular nearby structures or invasion of adjacent venous sinuses or bone, forcing incomplete excision and deployment of further salvage therapy."2.53ALA-induced fluorescence image guided surgery of meningiomas: A meta-analyses. ( Eljamel, S; Foster, N, 2016)
"ALA-FIGS in meningiomas is very selective, highly sensitive, and improves the extent of surgical resection in meningiomas."2.53ALA-induced fluorescence image guided surgery of meningiomas: A meta-analyses. ( Eljamel, S; Foster, N, 2016)
"5-aminolevulinic acid (5-ALA) has been established as an intraoperative tool in malignant glioma surgery."2.52The current status of 5-ALA fluorescence-guided resection of intracranial meningiomas-a critical review. ( Crane, LM; Groen, RJ; Jeltema, HR; Metzemaekers, JD; Motekallemi, A; van Dam, GM, 2015)
"Meningiomas are the second most common primary tumors affecting the central nervous system."2.52The current status of 5-ALA fluorescence-guided resection of intracranial meningiomas-a critical review. ( Crane, LM; Groen, RJ; Jeltema, HR; Metzemaekers, JD; Motekallemi, A; van Dam, GM, 2015)
"Tumor fluorescence can occur in benign meningiomas (WHO grade I) as well as in WHO grade II and WHO grade III meningiomas."2.52The current status of 5-ALA fluorescence-guided resection of intracranial meningiomas-a critical review. ( Crane, LM; Groen, RJ; Jeltema, HR; Metzemaekers, JD; Motekallemi, A; van Dam, GM, 2015)
"Meningiomas have a 5 year recurrence rate of 8%."1.915-aminolevulinic acid fluorescence guided surgery for resection of cystic meningioma with bone invasion. ( Cabezudo Artero, JM; Fernández Portales, I; García Moreno, R; Hidalgo Llorca, M; Ippolito Bastidas, H; Rubio Fernández, A, 2023)
"Complete neurosurgical resection of intracranial meningiomas is essential to avoid residual tumor tissue and thus minimize the risk of tumor recurrence."1.62High Diagnostic Accuracy of Visible 5-ALA Fluorescence in Meningioma Surgery According to Histopathological Analysis of Tumor Bulk and Peritumoral Tissue. ( Kiesel, B; Knosp, E; Makolli, J; Mercea, PA; Millesi, M; Mischkulnig, M; Roetzer, T; Rössler, K; Wadiura, LI; Wais, J; Widhalm, G, 2021)
" No difference was found when comparing the fluorescence between primary grade I and II meningiomas after any 5-ALA dosage (p > ."1.625-ALA kinetics in meningiomas: analysis of tumor fluorescence and PpIX metabolism in vitro and comparative analyses with high-grade gliomas. ( Brokinkel, B; Bunk, EC; Senner, V; Stummer, W; Wagner, A, 2021)
"Residents judged that eyestrain was strong (P = ."1.51Preliminary Clinical Microneurosurgical Experience With the 4K3-Dimensional Microvideoscope (ORBEYE) System for Microneurological Surgery: Observation Study. ( Morimoto, D; Morita, A; Murai, Y; Nozaki, T; Ozeki, T; Sato, S; Tahara, S; Tateyama, K; Yamaguchi, F; Yamaguchi, M; Yui, K, 2019)
"Twelve items including image quality, eyestrain, and function of the arm were evaluated."1.51Preliminary Clinical Microneurosurgical Experience With the 4K3-Dimensional Microvideoscope (ORBEYE) System for Microneurological Surgery: Observation Study. ( Morimoto, D; Morita, A; Murai, Y; Nozaki, T; Ozeki, T; Sato, S; Tahara, S; Tateyama, K; Yamaguchi, F; Yamaguchi, M; Yui, K, 2019)
"The first case was a small olfactory groove meningioma resected via a trans-eyebrow, subfrontal approach."1.51Surgery of Small Anterior Skull Base Meningiomas by Endoscopic 5-Aminolevulinic Acid Fluorescence Guidance: First Clinical Experience. ( Beez, T; Cornelius, JF; Kamp, MA; Knipps, J; Krause-Molle, Z; Petridis, AK; Sabel, M; Schipper, J; Steiger, HJ; Tortora, A, 2019)
"5-aminolevulinic acid (5-ALA) is a natural precursor of protoporphyrin IX (PP IX), which possesses fluorescent properties and is more intensively accumulated in tumor cells than in normal tissue."1.43Laser biospectroscopy and 5-ALA fluorescence navigation as a helpful tool in the meningioma resection. ( Chumakova, AP; Golbin, DA; Goldberg, MF; Goryaynov, SA; Loschenov, VB; Okhlopkov, VA; Potapov, AA; Savelieva, TA; Shishkina, LV; Spallone, A; Varyukhina, MD, 2016)
"Efficacy of 5-ALA PDT could be increased by adjunction of ciprofloxacin in conventional clinical dosing and by prolongation of ALA incubation time."1.40Enhancing the effect of 5-aminolevulinic acid based photodynamic therapy in human meningioma cells. ( Cornelius, JF; El Khatib, M; Giannakis, A; Senger, B; Slotty, PJ; Steiger, HJ, 2014)
"As ciprofloxacin is a common antibiotic with good tissue penetration, low toxicity and a favorable risk profile it represents a clinically interesting method for future PDT trials in meningiomas."1.40Enhancing the effect of 5-aminolevulinic acid based photodynamic therapy in human meningioma cells. ( Cornelius, JF; El Khatib, M; Giannakis, A; Senger, B; Slotty, PJ; Steiger, HJ, 2014)
"The patient harboring a sphenoid wing meningioma with intraorbital extension underwent radical resection of the tumor with both visibly and nonvisibly fluorescent regions."1.37Quantitative and qualitative 5-aminolevulinic acid-induced protoporphyrin IX fluorescence in skull base meningiomas. ( Bekelis, K; Erkmen, K; Harris, BT; Kim, A; Leblond, F; Paulsen, KD; Roberts, DW; Valdés, PA; Wilson, BC, 2011)
"5-aminolevulinic acid (5-ALA) has gained importance as an intraoperative photodynamic diagnostic agent for the extirpation of malignant gliomas."1.36Intraoperative 5-aminolevulinic-acid-induced fluorescence in meningiomas. ( Coluccia, D; Cordovi, S; Fandino, J; Fujioka, M; Landolt, H; Muroi, C, 2010)

Research

Studies (41)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (2.44)18.2507
2000's3 (7.32)29.6817
2010's29 (70.73)24.3611
2020's8 (19.51)2.80

Authors

AuthorsStudies
Peciu-Florianu, I1
Jaillard, A1
Tuleasca, C1
Reyns, N1
Scheichel, F1
Popadic, B1
Kitzwoegerer, M1
Ungersboeck, K1
Marhold, F1
Turcotte, EL1
Rahme, RJ1
Merrill, SA1
Hess, RA1
Lettieri, SC1
Bendok, BR1
Kaneko, S1
Brokinkel, B2
Suero Molina, E1
Warneke, N1
Holling, M1
Bunk, EC2
Hess, K1
Senner, V2
Paulus, W1
Stummer, W4
Wadiura, LI1
Millesi, M3
Makolli, J1
Wais, J1
Kiesel, B2
Mischkulnig, M2
Mercea, PA1
Roetzer, T1
Knosp, E2
Rössler, K1
Widhalm, G3
García Moreno, R1
Ippolito Bastidas, H1
Fernández Portales, I1
Rubio Fernández, A1
Hidalgo Llorca, M1
Cabezudo Artero, JM1
Wagner, A1
Linsler, S1
Müller, SJ1
Müller, A1
Senger, S1
Oertel, JM1
Knipps, J2
Beseoglu, K1
Kamp, M1
Fischer, I1
Felsberg, J1
Neumann, LM1
Steiger, HJ5
Cornelius, JF6
Prasad, GL1
Ruschel, LG1
Ramina, R1
da Silva, EB1
Cavalcanti, MS1
Duarte, JFS1
Kamp, MA2
Tortora, A1
Krause-Molle, Z1
Beez, T1
Petridis, AK1
Sabel, M1
Schipper, J1
Murai, Y1
Sato, S1
Yui, K1
Morimoto, D1
Ozeki, T1
Yamaguchi, M1
Tateyama, K1
Nozaki, T1
Tahara, S1
Yamaguchi, F1
Morita, A1
Dijkstra, BM1
Jeltema, HJR1
Kruijff, S1
Groen, RJM1
Valdes, PA5
Roberts, DW6
Rustemi, O3
Della Puppa, A3
Masubuchi, T1
Kajimoto, Y3
Kawabata, S1
Nonoguchi, N1
Fujishiro, T1
Miyatake, S3
Kuroiwa, T3
Bekelis, K2
Harris, BT4
Wilson, BC4
Leblond, F4
Kim, A3
Simmons, NE2
Erkmen, K3
Paulsen, KD5
Gioffrè, G2
Troncon, I1
Lombardi, G1
Rolma, G1
Sergi, M1
Munari, M1
Cecchin, D1
Gardiman, MP1
Scienza, R1
Slotty, PJ3
El Khatib, M1
Giannakis, A1
Senger, B2
Wilbers, E1
Hargus, G1
Wölfer, J1
Schneiderhan, TM1
El-Khatib, M2
Motekallemi, A1
Jeltema, HR1
Metzemaekers, JD1
van Dam, GM1
Crane, LM1
Groen, RJ1
Tepe, C1
Dibué-Adjei, M1
Riemenschneider, MJ1
Ferraro, N1
Barbarite, E1
Albert, TR1
Berchmans, E1
Shah, AH1
Bregy, A1
Ivan, ME1
Brown, T1
Komotar, RJ1
Potapov, AA1
Goryaynov, SA1
Okhlopkov, VA1
Shishkina, LV1
Loschenov, VB1
Savelieva, TA1
Golbin, DA1
Chumakova, AP1
Goldberg, MF1
Varyukhina, MD1
Spallone, A1
Foster, N1
Eljamel, S1
Coluccia, D1
Fandino, J1
Fujioka, M1
Cordovi, S1
Muroi, C1
Landolt, H1
Hefti, M1
Whitson, WJ1
Fan, X2
Tosteson, TD1
Hartov, A1
Ji, S1
Hueng, DY1
Tsao, CH1
Sytwu, HK1
Chen, YW1
Ichioka, T1
Miyashita, M1
Tanaka, H1
Tsuji, M1
Morofuji, Y1
Matsuo, T1
Hayashi, Y1
Suyama, K1
Nagata, I1
Tsai, JC1
Hsiao, YY1
Teng, LJ1
Chen, CT1
Kao, MC1
Olson, JD1
Evans, LT1
Kolste, KK1
Kanick, SC1
Bravo, JJ1
Marois, M1
Martínez-Moreno, M1
Wöhrer, A1
Wolfsberger, S1

Clinical Trials (4)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Computer Based Algorithm for Patient Specific Implants for Cranioplasty in Patients With Skull Defects: a Prospective Clinical Trial[NCT02828306]15 participants (Actual)Observational2016-09-30Completed
5-Aminolevulinic Acid (5-ALA) Gliolan®: Usage Increase Proposal for Neurosurgical Procedures in High-Grade Gliomas[NCT05850377]90 participants (Anticipated)Observational2023-06-01Not yet recruiting
Evaluation de l'intérêt de l'élastographie Ultrasonore et du Doppler Ultrasensible peropératoires Dans la Prise en Charge Chirurgicale Des Tumeurs cérébrales[NCT03970499]20 participants (Actual)Interventional2019-04-15Completed
Quantification of ALA-induced PpIX Fluorescence During Brain Tumor Resection[NCT02191488]Phase 1540 participants (Anticipated)Interventional2014-07-31Active, not recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

6 reviews available for aminolevulinic acid and Meningioma

ArticleYear
The application of fluorescence techniques in meningioma surgery-a review.
    Neurosurgical review, 2019, Volume: 42, Issue:4

    Topics: Aminolevulinic Acid; Fluorescein; Fluorescence; Fluorescent Dyes; Humans; Indocyanine Green; Levulin

2019
5-aminolevulinic acid induced protoporphyrin IX (ALA-PpIX) fluorescence guidance in meningioma surgery.
    Journal of neuro-oncology, 2019, Volume: 141, Issue:3

    Topics: Aminolevulinic Acid; Fluorescent Dyes; Humans; Meningeal Neoplasms; Meningioma; Optical Imaging; Pro

2019
The current status of 5-ALA fluorescence-guided resection of intracranial meningiomas-a critical review.
    Neurosurgical review, 2015, Volume: 38, Issue:4

    Topics: Aminolevulinic Acid; Fluorescent Dyes; Humans; Meningioma; Neurosurgical Procedures; Surgery, Comput

2015
The role of 5-aminolevulinic acid in brain tumor surgery: a systematic review.
    Neurosurgical review, 2016, Volume: 39, Issue:4

    Topics: Aminolevulinic Acid; Brain Neoplasms; Fluorescent Dyes; Glioma; Humans; Meningeal Neoplasms; Meningi

2016
ALA-induced fluorescence image guided surgery of meningiomas: A meta-analyses.
    Photodiagnosis and photodynamic therapy, 2016, Volume: 15

    Topics: Aged; Aged, 80 and over; Aminolevulinic Acid; Contrast Media; Female; Fluorescent Dyes; Humans; Male

2016
[Intraoperative photo-dynamic diagnosis of brain tumors].
    Brain and nerve = Shinkei kenkyu no shinpo, 2009, Volume: 61, Issue:7

    Topics: Adult; Aged; Aminolevulinic Acid; Brain Neoplasms; Female; Fluorescence; Glioma; Humans; Intraoperat

2009

Trials

3 trials available for aminolevulinic acid and Meningioma

ArticleYear
Impact of 5-aminolevulinic acid fluorescence-guided surgery on the extent of resection of meningiomas--with special regard to high-grade tumors.
    Photodiagnosis and photodynamic therapy, 2014, Volume: 11, Issue:4

    Topics: Adult; Aged; Aged, 80 and over; Aminolevulinic Acid; Contrast Media; Female; Fluorescent Dyes; Human

2014
Quantitative fluorescence in intracranial tumor: implications for ALA-induced PpIX as an intraoperative biomarker.
    Journal of neurosurgery, 2011, Volume: 115, Issue:1

    Topics: Adult; Aged; Aminolevulinic Acid; Biomarkers; Brain; Brain Neoplasms; Diagnostic Imaging; Female; Fl

2011
Red-light excitation of protoporphyrin IX fluorescence for subsurface tumor detection.
    Journal of neurosurgery, 2018, Volume: 128, Issue:6

    Topics: Adult; Aged; Aminolevulinic Acid; Brain Neoplasms; Craniotomy; Female; Fluorescence; Fluorescent Dye

2018

Other Studies

32 other studies available for aminolevulinic acid and Meningioma

ArticleYear
Benefits of combined use of
    Journal of medical case reports, 2023, Jul-15, Volume: 17, Issue:1

    Topics: Adult; Aminolevulinic Acid; Humans; Male; Meningeal Neoplasms; Meningioma; Microsurgery; Radiosurger

2023
Fluorescence-guided resection in bone and soft tissue infiltrating meningiomas.
    Acta neurochirurgica, 2020, Volume: 162, Issue:3

    Topics: Adult; Aged; Aminolevulinic Acid; Bone Neoplasms; Female; Fluorescence; Humans; Hyperostosis; Intrao

2020
The Utility of 5-Aminolevulinic Acid for Microsurgical Resection of Meningiomas.
    World neurosurgery, 2020, Volume: 139

    Topics: Aged; Aminolevulinic Acid; Female; Humans; Male; Meningeal Neoplasms; Meningioma; Microsurgery; Midd

2020
Real-time in vivo kinetics of protoporphyrin IX after administration of 5-aminolevulinic acid in meningiomas and comparative analyses with glioblastomas.
    Acta neurochirurgica, 2020, Volume: 162, Issue:9

    Topics: Aminolevulinic Acid; Fluorescence; Glioblastoma; Humans; Kinetics; Meningeal Neoplasms; Meningioma;

2020
High Diagnostic Accuracy of Visible 5-ALA Fluorescence in Meningioma Surgery According to Histopathological Analysis of Tumor Bulk and Peritumoral Tissue.
    Lasers in surgery and medicine, 2021, Volume: 53, Issue:3

    Topics: Aminolevulinic Acid; Humans; Meningeal Neoplasms; Meningioma; Neoplasm Recurrence, Local; Retrospect

2021
5-aminolevulinic acid fluorescence guided surgery for resection of cystic meningioma with bone invasion.
    British journal of neurosurgery, 2023, Volume: 37, Issue:5

    Topics: Aged; Aminolevulinic Acid; Fluorescence; Humans; Meningeal Neoplasms; Meningioma

2023
5-ALA kinetics in meningiomas: analysis of tumor fluorescence and PpIX metabolism in vitro and comparative analyses with high-grade gliomas.
    Journal of neuro-oncology, 2021, Volume: 152, Issue:1

    Topics: Aminolevulinic Acid; Cell Line, Tumor; Glioma; Humans; Kinetics; Meningeal Neoplasms; Meningioma; Op

2021
Fluorescence image-guided resection of intracranial meningioma: an experimental in vivo study on nude mice.
    Annals of anatomy = Anatomischer Anzeiger : official organ of the Anatomische Gesellschaft, 2021, Volume: 237

    Topics: Aminolevulinic Acid; Animals; Fluorescent Dyes; Meningeal Neoplasms; Meningioma; Mice; Mice, Nude

2021
Fluorescence Behavior and Dural Infiltration of Meningioma Analyzed by 5-Aminolevulinic Acid-Based Fluorescence: Operating Microscope Versus Mini-Spectrometer.
    World neurosurgery, 2017, Volume: 108

    Topics: Aminolevulinic Acid; Calibration; Dura Mater; Fluorescent Dyes; Humans; Magnetic Resonance Imaging;

2017
Letter to the Editor. Usefulness of 5-ALA in resection of intracranial meningiomas.
    Journal of neurosurgery, 2018, Volume: 128, Issue:3

    Topics: Aminolevulinic Acid; Fluorescence; Humans; Meningeal Neoplasms; Meningioma

2018
5-Aminolevulinic acid fluorescence-guided surgery for spinal cord melanoma metastasis: a technical note.
    Acta neurochirurgica, 2018, Volume: 160, Issue:10

    Topics: Adult; Aminolevulinic Acid; Brain Neoplasms; Ependymoma; Female; Fluorescent Dyes; Humans; Male; Mel

2018
Surgery of Small Anterior Skull Base Meningiomas by Endoscopic 5-Aminolevulinic Acid Fluorescence Guidance: First Clinical Experience.
    World neurosurgery, 2019, Volume: 122

    Topics: Adult; Aged; Aminolevulinic Acid; Female; Humans; Male; Meningeal Neoplasms; Meningioma; Microsurger

2019
Preliminary Clinical Microneurosurgical Experience With the 4K3-Dimensional Microvideoscope (ORBEYE) System for Microneurological Surgery: Observation Study.
    Operative neurosurgery (Hagerstown, Md.), 2019, 06-01, Volume: 16, Issue:6

    Topics: Adolescent; Adult; Aged; Aminolevulinic Acid; Asthenopia; Attitude of Health Personnel; Brain Neopla

2019
Hyperostosis and osteolysis in skull base meningiomas: are different nuances of 5-ALA fluorescence related to different invasion patterns?
    Journal of neurosurgical sciences, 2019, Volume: 63, Issue:4

    Topics: Aminolevulinic Acid; Fluorescence; Humans; Hyperostosis; Meningeal Neoplasms; Meningioma; Osteolysis

2019
Experimental study to understand nonspecific protoporphyrin IX fluorescence in brain tissues near tumors after 5-aminolevulinic acid administration.
    Photomedicine and laser surgery, 2013, Volume: 31, Issue:9

    Topics: Aminolevulinic Acid; Animals; Cell Line, Tumor; Fluorescence; Glioma; Meningioma; Protoporphyrins; R

2013
5-Aminolevulinic acid-induced protoporphyrin IX fluorescence in meningioma: qualitative and quantitative measurements in vivo.
    Neurosurgery, 2014, Volume: 10 Suppl 1

    Topics: Adult; Aged; Aged, 80 and over; Aminolevulinic Acid; Analysis of Variance; Cluster Analysis; Female;

2014
Predictive value of intraoperative 5-aminolevulinic acid-induced fluorescence for detecting bone invasion in meningioma surgery.
    Journal of neurosurgery, 2014, Volume: 120, Issue:4

    Topics: Adult; Aged; Aged, 80 and over; Aminolevulinic Acid; Female; Humans; Male; Meningeal Neoplasms; Meni

2014
Predictive value of intraoperative 5-aminolevulinic acid-induced fluorescence for detecting bone invasion in meningioma surgery.
    Journal of neurosurgery, 2014, Volume: 120, Issue:4

    Topics: Adult; Aged; Aged, 80 and over; Aminolevulinic Acid; Female; Humans; Male; Meningeal Neoplasms; Meni

2014
Predictive value of intraoperative 5-aminolevulinic acid-induced fluorescence for detecting bone invasion in meningioma surgery.
    Journal of neurosurgery, 2014, Volume: 120, Issue:4

    Topics: Adult; Aged; Aged, 80 and over; Aminolevulinic Acid; Female; Humans; Male; Meningeal Neoplasms; Meni

2014
Predictive value of intraoperative 5-aminolevulinic acid-induced fluorescence for detecting bone invasion in meningioma surgery.
    Journal of neurosurgery, 2014, Volume: 120, Issue:4

    Topics: Adult; Aged; Aged, 80 and over; Aminolevulinic Acid; Female; Humans; Male; Meningeal Neoplasms; Meni

2014
Enhancing the effect of 5-aminolevulinic acid based photodynamic therapy in human meningioma cells.
    Photodiagnosis and photodynamic therapy, 2014, Volume: 11, Issue:1

    Topics: Aminolevulinic Acid; Cell Line, Tumor; Cell Survival; Ciprofloxacin; Dose-Response Relationship, Dru

2014
Usefulness of 5-ALA (Gliolan®)-derived PPX fluorescence for demonstrating the extent of infiltration in atypical meningiomas.
    Acta neurochirurgica, 2014, Volume: 156, Issue:10

    Topics: Adult; Aminolevulinic Acid; Female; Fluorescence; Humans; Meningeal Neoplasms; Meningioma; Photosens

2014
Meningioma surgery in the era of 5-aminolevulinic acid fluorescence-guided surgery.
    Journal of neurosurgery, 2014, Volume: 121, Issue:3

    Topics: Aminolevulinic Acid; Female; Humans; Male; Meningeal Neoplasms; Meningioma; Skull Base Neoplasms

2014
Response.
    Journal of neurosurgery, 2014, Volume: 121, Issue:3

    Topics: Aminolevulinic Acid; Female; Humans; Male; Meningeal Neoplasms; Meningioma; Skull Base Neoplasms

2014
Aminolevulinic acid-mediated photodynamic therapy of human meningioma: an in vitro study on primary cell lines.
    International journal of molecular sciences, 2015, Apr-30, Volume: 16, Issue:5

    Topics: Adult; Aged; Aged, 80 and over; Aminolevulinic Acid; Cell Line, Tumor; Cell Survival; Dose-Response

2015
Laser biospectroscopy and 5-ALA fluorescence navigation as a helpful tool in the meningioma resection.
    Neurosurgical review, 2016, Volume: 39, Issue:3

    Topics: Adult; Aged; Aminolevulinic Acid; Female; Fluorescence; Humans; Male; Meningeal Neoplasms; Meningiom

2016
Intraoperative 5-aminolevulinic-acid-induced fluorescence in meningiomas.
    Acta neurochirurgica, 2010, Volume: 152, Issue:10

    Topics: Adult; Aged; Aminolevulinic Acid; Female; Fluorescence; Humans; Male; Meningeal Neoplasms; Meningiom

2010
Comment concerning: Intraoperative 5-aminolevulinic-acid-induced fluorescence in meningiomas, Acta Neurochir DOl 1O.1007/s00701-010-0708-4, Intratumoral heterogeneity and fluorescence intensity in meningioma after 5-ALA pretreatment.
    Acta neurochirurgica, 2011, Volume: 153, Issue:4

    Topics: Aminolevulinic Acid; Chromosome Aberrations; Fluorescence; Genetic Heterogeneity; Humans; Intraopera

2011
Confocal microscopy for the histological fluorescence pattern of a recurrent atypical meningioma: case report.
    Neurosurgery, 2011, Volume: 68, Issue:6

    Topics: Aminolevulinic Acid; Diagnostic Imaging; Female; Fluorescent Antibody Technique; Humans; Meningeal N

2011
Quantitative and qualitative 5-aminolevulinic acid-induced protoporphyrin IX fluorescence in skull base meningiomas.
    Neurosurgical focus, 2011, Volume: 30, Issue:5

    Topics: Aminolevulinic Acid; Diagnostic Imaging; Female; Humans; Meningeal Neoplasms; Meningioma; Middle Age

2011
Brain biopsy.
    Journal of neurosurgery, 2012, Volume: 117, Issue:2

    Topics: Aminolevulinic Acid; Biopsy; Brain; Brain Neoplasms; Glioma; Humans; Meningeal Neoplasms; Meningioma

2012
Use of 5-aminolevulinic acid in fluorescence-guided resection of meningioma with high risk of recurrence. Case report.
    Journal of neurosurgery, 2007, Volume: 106, Issue:6

    Topics: Aged; Aminolevulinic Acid; Craniotomy; Female; Fluorescence; Humans; Magnetic Resonance Imaging; Men

2007
Usefulness of intraoperative photodynamic diagnosis using 5-aminolevulinic acid for meningiomas with cranial invasion: technical case report.
    Neurosurgery, 2008, Volume: 62, Issue:3 Suppl 1

    Topics: Aged, 80 and over; Aminolevulinic Acid; Brain; Contrast Media; Female; Humans; Intraoperative Care;

2008
Comparative study on the ALA photodynamic effects of human glioma and meningioma cells.
    Lasers in surgery and medicine, 1999, Volume: 24, Issue:4

    Topics: Aminolevulinic Acid; Analysis of Variance; Dose-Response Relationship, Radiation; Epidermal Growth F

1999
Analysis of the surgical benefits of 5-ALA-induced fluorescence in intracranial meningiomas: experience in 204 meningiomas.
    Journal of neurosurgery, 2016, Volume: 125, Issue:6

    Topics: Adult; Aged; Aged, 80 and over; Aminolevulinic Acid; Brain Neoplasms; Female; Fluorescence; Humans;

2016