aminolevulinic acid has been researched along with Meningioma in 41 studies
Aminolevulinic Acid: A compound produced from succinyl-CoA and GLYCINE as an intermediate in heme synthesis. It is used as a PHOTOCHEMOTHERAPY for actinic KERATOSIS.
5-aminolevulinic acid : The simplest delta-amino acid in which the hydrogens at the gamma position are replaced by an oxo group. It is metabolised to protoporphyrin IX, a photoactive compound which accumulates in the skin. Used (in the form of the hydrochloride salt)in combination with blue light illumination for the treatment of minimally to moderately thick actinic keratosis of the face or scalp.
Meningioma: A relatively common neoplasm of the CENTRAL NERVOUS SYSTEM that arises from arachnoidal cells. The majority are well differentiated vascular tumors which grow slowly and have a low potential to be invasive, although malignant subtypes occur. Meningiomas have a predilection to arise from the parasagittal region, cerebral convexity, sphenoidal ridge, olfactory groove, and SPINAL CANAL. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, pp2056-7)
| Excerpt | Relevance | Reference |
|---|---|---|
| "The usefulness of 5-aminolevulinic acid (5-ALA)-mediated fluorescence-guided surgery (FGS) in meningiomas is intensely discussed." | 7.96 | Real-time in vivo kinetics of protoporphyrin IX after administration of 5-aminolevulinic acid in meningiomas and comparative analyses with glioblastomas. ( Brokinkel, B; Bunk, EC; Hess, K; Holling, M; Kaneko, S; Paulus, W; Senner, V; Stummer, W; Suero Molina, E; Warneke, N, 2020) |
| "To compare fluorescence intensity of tumor specimens, as measured by a fluorescence-guided surgery microscope and a spectrometer, to evaluate tumor infiltration of dura mater around meningiomas with help of these 2 different 5-aminolevulinic acid (5-ALA)-based fluorescence tools, and to correlate fluorescence intensity with histopathologic data." | 7.85 | Fluorescence Behavior and Dural Infiltration of Meningioma Analyzed by 5-Aminolevulinic Acid-Based Fluorescence: Operating Microscope Versus Mini-Spectrometer. ( Beseoglu, K; Cornelius, JF; Felsberg, J; Fischer, I; Kamp, M; Knipps, J; Neumann, LM; Steiger, HJ, 2017) |
| "Ciprofloxacin and longer ALA incubation time significantly increased the lethal effect of 5-ALA PDT on meningioma cells." | 7.80 | Enhancing the effect of 5-aminolevulinic acid based photodynamic therapy in human meningioma cells. ( Cornelius, JF; El Khatib, M; Giannakis, A; Senger, B; Slotty, PJ; Steiger, HJ, 2014) |
| "To the best of our knowledge, this is the first case demonstrating the efficacy of PDD using 5-aminolevulinic acid for a meningioma with cranial invasion." | 7.74 | Usefulness of intraoperative photodynamic diagnosis using 5-aminolevulinic acid for meningiomas with cranial invasion: technical case report. ( Hayashi, Y; Matsuo, T; Morofuji, Y; Nagata, I; Suyama, K, 2008) |
| "We present a case of a meningioma in which photodynamic diagnosis (PDD) using 5-aminolevulinic acid was very useful in identifying the cranial involvement." | 7.74 | Usefulness of intraoperative photodynamic diagnosis using 5-aminolevulinic acid for meningiomas with cranial invasion: technical case report. ( Hayashi, Y; Matsuo, T; Morofuji, Y; Nagata, I; Suyama, K, 2008) |
| "Meningiomas have a 5 year recurrence rate of 8%." | 5.91 | 5-aminolevulinic acid fluorescence guided surgery for resection of cystic meningioma with bone invasion. ( Cabezudo Artero, JM; Fernández Portales, I; García Moreno, R; Hidalgo Llorca, M; Ippolito Bastidas, H; Rubio Fernández, A, 2023) |
| "The first case was a small olfactory groove meningioma resected via a trans-eyebrow, subfrontal approach." | 5.51 | Surgery of Small Anterior Skull Base Meningiomas by Endoscopic 5-Aminolevulinic Acid Fluorescence Guidance: First Clinical Experience. ( Beez, T; Cornelius, JF; Kamp, MA; Knipps, J; Krause-Molle, Z; Petridis, AK; Sabel, M; Schipper, J; Steiger, HJ; Tortora, A, 2019) |
| "As ciprofloxacin is a common antibiotic with good tissue penetration, low toxicity and a favorable risk profile it represents a clinically interesting method for future PDT trials in meningiomas." | 5.40 | Enhancing the effect of 5-aminolevulinic acid based photodynamic therapy in human meningioma cells. ( Cornelius, JF; El Khatib, M; Giannakis, A; Senger, B; Slotty, PJ; Steiger, HJ, 2014) |
| "Efficacy of 5-ALA PDT could be increased by adjunction of ciprofloxacin in conventional clinical dosing and by prolongation of ALA incubation time." | 5.40 | Enhancing the effect of 5-aminolevulinic acid based photodynamic therapy in human meningioma cells. ( Cornelius, JF; El Khatib, M; Giannakis, A; Senger, B; Slotty, PJ; Steiger, HJ, 2014) |
| "The patient harboring a sphenoid wing meningioma with intraorbital extension underwent radical resection of the tumor with both visibly and nonvisibly fluorescent regions." | 5.37 | Quantitative and qualitative 5-aminolevulinic acid-induced protoporphyrin IX fluorescence in skull base meningiomas. ( Bekelis, K; Erkmen, K; Harris, BT; Kim, A; Leblond, F; Paulsen, KD; Roberts, DW; Valdés, PA; Wilson, BC, 2011) |
| "OBJECTIVE The objective of this study was to detect 5-aminolevulinic acid (ALA)-induced tumor fluorescence from glioma below the surface of the surgical field by using red-light illumination." | 5.27 | Red-light excitation of protoporphyrin IX fluorescence for subsurface tumor detection. ( Bravo, JJ; Evans, LT; Fan, X; Kanick, SC; Kolste, KK; Leblond, F; Marois, M; Olson, JD; Paulsen, KD; Roberts, DW; Wilson, BC, 2018) |
| " Qualitative fluorescence of protoporphyrin IX (PpIX), synthesized endogenously following δ-aminolevulinic acid (ALA) administration, has been used for this purpose in high-grade glioma (HGG)." | 5.15 | Quantitative fluorescence in intracranial tumor: implications for ALA-induced PpIX as an intraoperative biomarker. ( Erkmen, K; Fan, X; Harris, BT; Hartov, A; Ji, S; Kim, A; Leblond, F; Paulsen, KD; Roberts, DW; Simmons, NE; Tosteson, TD; Valdés, PA; Wilson, BC, 2011) |
| "Conventionary, we use 5-aminolevulinic acid (5-ALA) for photo-dynamic diagnosis in the removal of malignant gliomas." | 4.85 | [Intraoperative photo-dynamic diagnosis of brain tumors]. ( Kajimoto, Y; Kuroiwa, T; Miyatake, S, 2009) |
| "Studies of novel microsurgical adjuncts, such as 5-aminolevulinic acid (5-ALA) fluorescence have shown various fluorescence patterns within meningiomas, opening new avenues for complete microsurgical resection." | 4.31 | Benefits of combined use of ( Jaillard, A; Peciu-Florianu, I; Reyns, N; Tuleasca, C, 2023) |
| "Although the utility 5-aminolevulinic acid (5-ALA)-mediated fluorescence-guided surgery (FGS) in meningiomas is increasingly discussed, data about the kinetics of protoporphyrin IX (PpIX) and tumor fluorescence are sparse." | 4.02 | 5-ALA kinetics in meningiomas: analysis of tumor fluorescence and PpIX metabolism in vitro and comparative analyses with high-grade gliomas. ( Brokinkel, B; Bunk, EC; Senner, V; Stummer, W; Wagner, A, 2021) |
| "The usefulness of 5-aminolevulinic acid (5-ALA)-mediated fluorescence-guided surgery (FGS) in meningiomas is intensely discussed." | 3.96 | Real-time in vivo kinetics of protoporphyrin IX after administration of 5-aminolevulinic acid in meningiomas and comparative analyses with glioblastomas. ( Brokinkel, B; Bunk, EC; Hess, K; Holling, M; Kaneko, S; Paulus, W; Senner, V; Stummer, W; Suero Molina, E; Warneke, N, 2020) |
| "To compare fluorescence intensity of tumor specimens, as measured by a fluorescence-guided surgery microscope and a spectrometer, to evaluate tumor infiltration of dura mater around meningiomas with help of these 2 different 5-aminolevulinic acid (5-ALA)-based fluorescence tools, and to correlate fluorescence intensity with histopathologic data." | 3.85 | Fluorescence Behavior and Dural Infiltration of Meningioma Analyzed by 5-Aminolevulinic Acid-Based Fluorescence: Operating Microscope Versus Mini-Spectrometer. ( Beseoglu, K; Cornelius, JF; Felsberg, J; Fischer, I; Kamp, M; Knipps, J; Neumann, LM; Steiger, HJ, 2017) |
| "Ciprofloxacin and longer ALA incubation time significantly increased the lethal effect of 5-ALA PDT on meningioma cells." | 3.80 | Enhancing the effect of 5-aminolevulinic acid based photodynamic therapy in human meningioma cells. ( Cornelius, JF; El Khatib, M; Giannakis, A; Senger, B; Slotty, PJ; Steiger, HJ, 2014) |
| "(PpIX) fluorescence induced by 5-aminolevulinic acid (5-ALA), which appears in various tumors including malignant gliomas, is a good navigator for tumor resection." | 3.79 | Experimental study to understand nonspecific protoporphyrin IX fluorescence in brain tissues near tumors after 5-aminolevulinic acid administration. ( Fujishiro, T; Kajimoto, Y; Kawabata, S; Kuroiwa, T; Masubuchi, T; Miyatake, S; Nonoguchi, N, 2013) |
| "Fluorescence-guided resection with 5-aminolevulinic acid (5-ALA), which has shown promising results in the resection of malignant gliomas, has been used for meningioma resection in an attempt to more clearly delineate the tumor margin." | 3.77 | Confocal microscopy for the histological fluorescence pattern of a recurrent atypical meningioma: case report. ( Harris, BT; Paulsen, KD; Roberts, DW; Valdes, PA; Whitson, WJ, 2011) |
| "We present a case of a meningioma in which photodynamic diagnosis (PDD) using 5-aminolevulinic acid was very useful in identifying the cranial involvement." | 3.74 | Usefulness of intraoperative photodynamic diagnosis using 5-aminolevulinic acid for meningiomas with cranial invasion: technical case report. ( Hayashi, Y; Matsuo, T; Morofuji, Y; Nagata, I; Suyama, K, 2008) |
| "To the best of our knowledge, this is the first case demonstrating the efficacy of PDD using 5-aminolevulinic acid for a meningioma with cranial invasion." | 3.74 | Usefulness of intraoperative photodynamic diagnosis using 5-aminolevulinic acid for meningiomas with cranial invasion: technical case report. ( Hayashi, Y; Matsuo, T; Morofuji, Y; Nagata, I; Suyama, K, 2008) |
| "Though meningiomas are often benign and well circumscribed in nature, many are associated with recurrences and poor outcome because of their attachment to neurovascular nearby structures or invasion of adjacent venous sinuses or bone, forcing incomplete excision and deployment of further salvage therapy." | 2.53 | ALA-induced fluorescence image guided surgery of meningiomas: A meta-analyses. ( Eljamel, S; Foster, N, 2016) |
| "ALA-FIGS in meningiomas is very selective, highly sensitive, and improves the extent of surgical resection in meningiomas." | 2.53 | ALA-induced fluorescence image guided surgery of meningiomas: A meta-analyses. ( Eljamel, S; Foster, N, 2016) |
| "5-aminolevulinic acid (5-ALA) has been established as an intraoperative tool in malignant glioma surgery." | 2.52 | The current status of 5-ALA fluorescence-guided resection of intracranial meningiomas-a critical review. ( Crane, LM; Groen, RJ; Jeltema, HR; Metzemaekers, JD; Motekallemi, A; van Dam, GM, 2015) |
| "Meningiomas are the second most common primary tumors affecting the central nervous system." | 2.52 | The current status of 5-ALA fluorescence-guided resection of intracranial meningiomas-a critical review. ( Crane, LM; Groen, RJ; Jeltema, HR; Metzemaekers, JD; Motekallemi, A; van Dam, GM, 2015) |
| "Tumor fluorescence can occur in benign meningiomas (WHO grade I) as well as in WHO grade II and WHO grade III meningiomas." | 2.52 | The current status of 5-ALA fluorescence-guided resection of intracranial meningiomas-a critical review. ( Crane, LM; Groen, RJ; Jeltema, HR; Metzemaekers, JD; Motekallemi, A; van Dam, GM, 2015) |
| "Meningiomas have a 5 year recurrence rate of 8%." | 1.91 | 5-aminolevulinic acid fluorescence guided surgery for resection of cystic meningioma with bone invasion. ( Cabezudo Artero, JM; Fernández Portales, I; García Moreno, R; Hidalgo Llorca, M; Ippolito Bastidas, H; Rubio Fernández, A, 2023) |
| "Complete neurosurgical resection of intracranial meningiomas is essential to avoid residual tumor tissue and thus minimize the risk of tumor recurrence." | 1.62 | High Diagnostic Accuracy of Visible 5-ALA Fluorescence in Meningioma Surgery According to Histopathological Analysis of Tumor Bulk and Peritumoral Tissue. ( Kiesel, B; Knosp, E; Makolli, J; Mercea, PA; Millesi, M; Mischkulnig, M; Roetzer, T; Rössler, K; Wadiura, LI; Wais, J; Widhalm, G, 2021) |
| " No difference was found when comparing the fluorescence between primary grade I and II meningiomas after any 5-ALA dosage (p > ." | 1.62 | 5-ALA kinetics in meningiomas: analysis of tumor fluorescence and PpIX metabolism in vitro and comparative analyses with high-grade gliomas. ( Brokinkel, B; Bunk, EC; Senner, V; Stummer, W; Wagner, A, 2021) |
| "Residents judged that eyestrain was strong (P = ." | 1.51 | Preliminary Clinical Microneurosurgical Experience With the 4K3-Dimensional Microvideoscope (ORBEYE) System for Microneurological Surgery: Observation Study. ( Morimoto, D; Morita, A; Murai, Y; Nozaki, T; Ozeki, T; Sato, S; Tahara, S; Tateyama, K; Yamaguchi, F; Yamaguchi, M; Yui, K, 2019) |
| "Twelve items including image quality, eyestrain, and function of the arm were evaluated." | 1.51 | Preliminary Clinical Microneurosurgical Experience With the 4K3-Dimensional Microvideoscope (ORBEYE) System for Microneurological Surgery: Observation Study. ( Morimoto, D; Morita, A; Murai, Y; Nozaki, T; Ozeki, T; Sato, S; Tahara, S; Tateyama, K; Yamaguchi, F; Yamaguchi, M; Yui, K, 2019) |
| "The first case was a small olfactory groove meningioma resected via a trans-eyebrow, subfrontal approach." | 1.51 | Surgery of Small Anterior Skull Base Meningiomas by Endoscopic 5-Aminolevulinic Acid Fluorescence Guidance: First Clinical Experience. ( Beez, T; Cornelius, JF; Kamp, MA; Knipps, J; Krause-Molle, Z; Petridis, AK; Sabel, M; Schipper, J; Steiger, HJ; Tortora, A, 2019) |
| "5-aminolevulinic acid (5-ALA) is a natural precursor of protoporphyrin IX (PP IX), which possesses fluorescent properties and is more intensively accumulated in tumor cells than in normal tissue." | 1.43 | Laser biospectroscopy and 5-ALA fluorescence navigation as a helpful tool in the meningioma resection. ( Chumakova, AP; Golbin, DA; Goldberg, MF; Goryaynov, SA; Loschenov, VB; Okhlopkov, VA; Potapov, AA; Savelieva, TA; Shishkina, LV; Spallone, A; Varyukhina, MD, 2016) |
| "Efficacy of 5-ALA PDT could be increased by adjunction of ciprofloxacin in conventional clinical dosing and by prolongation of ALA incubation time." | 1.40 | Enhancing the effect of 5-aminolevulinic acid based photodynamic therapy in human meningioma cells. ( Cornelius, JF; El Khatib, M; Giannakis, A; Senger, B; Slotty, PJ; Steiger, HJ, 2014) |
| "As ciprofloxacin is a common antibiotic with good tissue penetration, low toxicity and a favorable risk profile it represents a clinically interesting method for future PDT trials in meningiomas." | 1.40 | Enhancing the effect of 5-aminolevulinic acid based photodynamic therapy in human meningioma cells. ( Cornelius, JF; El Khatib, M; Giannakis, A; Senger, B; Slotty, PJ; Steiger, HJ, 2014) |
| "The patient harboring a sphenoid wing meningioma with intraorbital extension underwent radical resection of the tumor with both visibly and nonvisibly fluorescent regions." | 1.37 | Quantitative and qualitative 5-aminolevulinic acid-induced protoporphyrin IX fluorescence in skull base meningiomas. ( Bekelis, K; Erkmen, K; Harris, BT; Kim, A; Leblond, F; Paulsen, KD; Roberts, DW; Valdés, PA; Wilson, BC, 2011) |
| "5-aminolevulinic acid (5-ALA) has gained importance as an intraoperative photodynamic diagnostic agent for the extirpation of malignant gliomas." | 1.36 | Intraoperative 5-aminolevulinic-acid-induced fluorescence in meningiomas. ( Coluccia, D; Cordovi, S; Fandino, J; Fujioka, M; Landolt, H; Muroi, C, 2010) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (2.44) | 18.2507 |
| 2000's | 3 (7.32) | 29.6817 |
| 2010's | 29 (70.73) | 24.3611 |
| 2020's | 8 (19.51) | 2.80 |
| Authors | Studies |
|---|---|
| Peciu-Florianu, I | 1 |
| Jaillard, A | 1 |
| Tuleasca, C | 1 |
| Reyns, N | 1 |
| Scheichel, F | 1 |
| Popadic, B | 1 |
| Kitzwoegerer, M | 1 |
| Ungersboeck, K | 1 |
| Marhold, F | 1 |
| Turcotte, EL | 1 |
| Rahme, RJ | 1 |
| Merrill, SA | 1 |
| Hess, RA | 1 |
| Lettieri, SC | 1 |
| Bendok, BR | 1 |
| Kaneko, S | 1 |
| Brokinkel, B | 2 |
| Suero Molina, E | 1 |
| Warneke, N | 1 |
| Holling, M | 1 |
| Bunk, EC | 2 |
| Hess, K | 1 |
| Senner, V | 2 |
| Paulus, W | 1 |
| Stummer, W | 4 |
| Wadiura, LI | 1 |
| Millesi, M | 3 |
| Makolli, J | 1 |
| Wais, J | 1 |
| Kiesel, B | 2 |
| Mischkulnig, M | 2 |
| Mercea, PA | 1 |
| Roetzer, T | 1 |
| Knosp, E | 2 |
| Rössler, K | 1 |
| Widhalm, G | 3 |
| García Moreno, R | 1 |
| Ippolito Bastidas, H | 1 |
| Fernández Portales, I | 1 |
| Rubio Fernández, A | 1 |
| Hidalgo Llorca, M | 1 |
| Cabezudo Artero, JM | 1 |
| Wagner, A | 1 |
| Linsler, S | 1 |
| Müller, SJ | 1 |
| Müller, A | 1 |
| Senger, S | 1 |
| Oertel, JM | 1 |
| Knipps, J | 2 |
| Beseoglu, K | 1 |
| Kamp, M | 1 |
| Fischer, I | 1 |
| Felsberg, J | 1 |
| Neumann, LM | 1 |
| Steiger, HJ | 5 |
| Cornelius, JF | 6 |
| Prasad, GL | 1 |
| Ruschel, LG | 1 |
| Ramina, R | 1 |
| da Silva, EB | 1 |
| Cavalcanti, MS | 1 |
| Duarte, JFS | 1 |
| Kamp, MA | 2 |
| Tortora, A | 1 |
| Krause-Molle, Z | 1 |
| Beez, T | 1 |
| Petridis, AK | 1 |
| Sabel, M | 1 |
| Schipper, J | 1 |
| Murai, Y | 1 |
| Sato, S | 1 |
| Yui, K | 1 |
| Morimoto, D | 1 |
| Ozeki, T | 1 |
| Yamaguchi, M | 1 |
| Tateyama, K | 1 |
| Nozaki, T | 1 |
| Tahara, S | 1 |
| Yamaguchi, F | 1 |
| Morita, A | 1 |
| Dijkstra, BM | 1 |
| Jeltema, HJR | 1 |
| Kruijff, S | 1 |
| Groen, RJM | 1 |
| Valdes, PA | 5 |
| Roberts, DW | 6 |
| Rustemi, O | 3 |
| Della Puppa, A | 3 |
| Masubuchi, T | 1 |
| Kajimoto, Y | 3 |
| Kawabata, S | 1 |
| Nonoguchi, N | 1 |
| Fujishiro, T | 1 |
| Miyatake, S | 3 |
| Kuroiwa, T | 3 |
| Bekelis, K | 2 |
| Harris, BT | 4 |
| Wilson, BC | 4 |
| Leblond, F | 4 |
| Kim, A | 3 |
| Simmons, NE | 2 |
| Erkmen, K | 3 |
| Paulsen, KD | 5 |
| Gioffrè, G | 2 |
| Troncon, I | 1 |
| Lombardi, G | 1 |
| Rolma, G | 1 |
| Sergi, M | 1 |
| Munari, M | 1 |
| Cecchin, D | 1 |
| Gardiman, MP | 1 |
| Scienza, R | 1 |
| Slotty, PJ | 3 |
| El Khatib, M | 1 |
| Giannakis, A | 1 |
| Senger, B | 2 |
| Wilbers, E | 1 |
| Hargus, G | 1 |
| Wölfer, J | 1 |
| Schneiderhan, TM | 1 |
| El-Khatib, M | 2 |
| Motekallemi, A | 1 |
| Jeltema, HR | 1 |
| Metzemaekers, JD | 1 |
| van Dam, GM | 1 |
| Crane, LM | 1 |
| Groen, RJ | 1 |
| Tepe, C | 1 |
| Dibué-Adjei, M | 1 |
| Riemenschneider, MJ | 1 |
| Ferraro, N | 1 |
| Barbarite, E | 1 |
| Albert, TR | 1 |
| Berchmans, E | 1 |
| Shah, AH | 1 |
| Bregy, A | 1 |
| Ivan, ME | 1 |
| Brown, T | 1 |
| Komotar, RJ | 1 |
| Potapov, AA | 1 |
| Goryaynov, SA | 1 |
| Okhlopkov, VA | 1 |
| Shishkina, LV | 1 |
| Loschenov, VB | 1 |
| Savelieva, TA | 1 |
| Golbin, DA | 1 |
| Chumakova, AP | 1 |
| Goldberg, MF | 1 |
| Varyukhina, MD | 1 |
| Spallone, A | 1 |
| Foster, N | 1 |
| Eljamel, S | 1 |
| Coluccia, D | 1 |
| Fandino, J | 1 |
| Fujioka, M | 1 |
| Cordovi, S | 1 |
| Muroi, C | 1 |
| Landolt, H | 1 |
| Hefti, M | 1 |
| Whitson, WJ | 1 |
| Fan, X | 2 |
| Tosteson, TD | 1 |
| Hartov, A | 1 |
| Ji, S | 1 |
| Hueng, DY | 1 |
| Tsao, CH | 1 |
| Sytwu, HK | 1 |
| Chen, YW | 1 |
| Ichioka, T | 1 |
| Miyashita, M | 1 |
| Tanaka, H | 1 |
| Tsuji, M | 1 |
| Morofuji, Y | 1 |
| Matsuo, T | 1 |
| Hayashi, Y | 1 |
| Suyama, K | 1 |
| Nagata, I | 1 |
| Tsai, JC | 1 |
| Hsiao, YY | 1 |
| Teng, LJ | 1 |
| Chen, CT | 1 |
| Kao, MC | 1 |
| Olson, JD | 1 |
| Evans, LT | 1 |
| Kolste, KK | 1 |
| Kanick, SC | 1 |
| Bravo, JJ | 1 |
| Marois, M | 1 |
| Martínez-Moreno, M | 1 |
| Wöhrer, A | 1 |
| Wolfsberger, S | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Computer Based Algorithm for Patient Specific Implants for Cranioplasty in Patients With Skull Defects: a Prospective Clinical Trial[NCT02828306] | 15 participants (Actual) | Observational | 2016-09-30 | Completed | |||
| 5-Aminolevulinic Acid (5-ALA) Gliolan®: Usage Increase Proposal for Neurosurgical Procedures in High-Grade Gliomas[NCT05850377] | 90 participants (Anticipated) | Observational | 2023-06-01 | Not yet recruiting | |||
| Evaluation de l'intérêt de l'élastographie Ultrasonore et du Doppler Ultrasensible peropératoires Dans la Prise en Charge Chirurgicale Des Tumeurs cérébrales[NCT03970499] | 20 participants (Actual) | Interventional | 2019-04-15 | Completed | |||
| Quantification of ALA-induced PpIX Fluorescence During Brain Tumor Resection[NCT02191488] | Phase 1 | 540 participants (Anticipated) | Interventional | 2014-07-31 | Active, not recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
6 reviews available for aminolevulinic acid and Meningioma
| Article | Year |
|---|---|
The application of fluorescence techniques in meningioma surgery-a review.
Topics: Aminolevulinic Acid; Fluorescein; Fluorescence; Fluorescent Dyes; Humans; Indocyanine Green; Levulin | 2019 |
5-aminolevulinic acid induced protoporphyrin IX (ALA-PpIX) fluorescence guidance in meningioma surgery.
Topics: Aminolevulinic Acid; Fluorescent Dyes; Humans; Meningeal Neoplasms; Meningioma; Optical Imaging; Pro | 2019 |
The current status of 5-ALA fluorescence-guided resection of intracranial meningiomas-a critical review.
Topics: Aminolevulinic Acid; Fluorescent Dyes; Humans; Meningioma; Neurosurgical Procedures; Surgery, Comput | 2015 |
The role of 5-aminolevulinic acid in brain tumor surgery: a systematic review.
Topics: Aminolevulinic Acid; Brain Neoplasms; Fluorescent Dyes; Glioma; Humans; Meningeal Neoplasms; Meningi | 2016 |
ALA-induced fluorescence image guided surgery of meningiomas: A meta-analyses.
Topics: Aged; Aged, 80 and over; Aminolevulinic Acid; Contrast Media; Female; Fluorescent Dyes; Humans; Male | 2016 |
[Intraoperative photo-dynamic diagnosis of brain tumors].
Topics: Adult; Aged; Aminolevulinic Acid; Brain Neoplasms; Female; Fluorescence; Glioma; Humans; Intraoperat | 2009 |
3 trials available for aminolevulinic acid and Meningioma
| Article | Year |
|---|---|
Impact of 5-aminolevulinic acid fluorescence-guided surgery on the extent of resection of meningiomas--with special regard to high-grade tumors.
Topics: Adult; Aged; Aged, 80 and over; Aminolevulinic Acid; Contrast Media; Female; Fluorescent Dyes; Human | 2014 |
Quantitative fluorescence in intracranial tumor: implications for ALA-induced PpIX as an intraoperative biomarker.
Topics: Adult; Aged; Aminolevulinic Acid; Biomarkers; Brain; Brain Neoplasms; Diagnostic Imaging; Female; Fl | 2011 |
Red-light excitation of protoporphyrin IX fluorescence for subsurface tumor detection.
Topics: Adult; Aged; Aminolevulinic Acid; Brain Neoplasms; Craniotomy; Female; Fluorescence; Fluorescent Dye | 2018 |
32 other studies available for aminolevulinic acid and Meningioma
| Article | Year |
|---|---|
Benefits of combined use of
Topics: Adult; Aminolevulinic Acid; Humans; Male; Meningeal Neoplasms; Meningioma; Microsurgery; Radiosurger | 2023 |
Fluorescence-guided resection in bone and soft tissue infiltrating meningiomas.
Topics: Adult; Aged; Aminolevulinic Acid; Bone Neoplasms; Female; Fluorescence; Humans; Hyperostosis; Intrao | 2020 |
The Utility of 5-Aminolevulinic Acid for Microsurgical Resection of Meningiomas.
Topics: Aged; Aminolevulinic Acid; Female; Humans; Male; Meningeal Neoplasms; Meningioma; Microsurgery; Midd | 2020 |
Real-time in vivo kinetics of protoporphyrin IX after administration of 5-aminolevulinic acid in meningiomas and comparative analyses with glioblastomas.
Topics: Aminolevulinic Acid; Fluorescence; Glioblastoma; Humans; Kinetics; Meningeal Neoplasms; Meningioma; | 2020 |
High Diagnostic Accuracy of Visible 5-ALA Fluorescence in Meningioma Surgery According to Histopathological Analysis of Tumor Bulk and Peritumoral Tissue.
Topics: Aminolevulinic Acid; Humans; Meningeal Neoplasms; Meningioma; Neoplasm Recurrence, Local; Retrospect | 2021 |
5-aminolevulinic acid fluorescence guided surgery for resection of cystic meningioma with bone invasion.
Topics: Aged; Aminolevulinic Acid; Fluorescence; Humans; Meningeal Neoplasms; Meningioma | 2023 |
5-ALA kinetics in meningiomas: analysis of tumor fluorescence and PpIX metabolism in vitro and comparative analyses with high-grade gliomas.
Topics: Aminolevulinic Acid; Cell Line, Tumor; Glioma; Humans; Kinetics; Meningeal Neoplasms; Meningioma; Op | 2021 |
Fluorescence image-guided resection of intracranial meningioma: an experimental in vivo study on nude mice.
Topics: Aminolevulinic Acid; Animals; Fluorescent Dyes; Meningeal Neoplasms; Meningioma; Mice; Mice, Nude | 2021 |
Fluorescence Behavior and Dural Infiltration of Meningioma Analyzed by 5-Aminolevulinic Acid-Based Fluorescence: Operating Microscope Versus Mini-Spectrometer.
Topics: Aminolevulinic Acid; Calibration; Dura Mater; Fluorescent Dyes; Humans; Magnetic Resonance Imaging; | 2017 |
Letter to the Editor. Usefulness of 5-ALA in resection of intracranial meningiomas.
Topics: Aminolevulinic Acid; Fluorescence; Humans; Meningeal Neoplasms; Meningioma | 2018 |
5-Aminolevulinic acid fluorescence-guided surgery for spinal cord melanoma metastasis: a technical note.
Topics: Adult; Aminolevulinic Acid; Brain Neoplasms; Ependymoma; Female; Fluorescent Dyes; Humans; Male; Mel | 2018 |
Surgery of Small Anterior Skull Base Meningiomas by Endoscopic 5-Aminolevulinic Acid Fluorescence Guidance: First Clinical Experience.
Topics: Adult; Aged; Aminolevulinic Acid; Female; Humans; Male; Meningeal Neoplasms; Meningioma; Microsurger | 2019 |
Preliminary Clinical Microneurosurgical Experience With the 4K3-Dimensional Microvideoscope (ORBEYE) System for Microneurological Surgery: Observation Study.
Topics: Adolescent; Adult; Aged; Aminolevulinic Acid; Asthenopia; Attitude of Health Personnel; Brain Neopla | 2019 |
Hyperostosis and osteolysis in skull base meningiomas: are different nuances of 5-ALA fluorescence related to different invasion patterns?
Topics: Aminolevulinic Acid; Fluorescence; Humans; Hyperostosis; Meningeal Neoplasms; Meningioma; Osteolysis | 2019 |
Experimental study to understand nonspecific protoporphyrin IX fluorescence in brain tissues near tumors after 5-aminolevulinic acid administration.
Topics: Aminolevulinic Acid; Animals; Cell Line, Tumor; Fluorescence; Glioma; Meningioma; Protoporphyrins; R | 2013 |
5-Aminolevulinic acid-induced protoporphyrin IX fluorescence in meningioma: qualitative and quantitative measurements in vivo.
Topics: Adult; Aged; Aged, 80 and over; Aminolevulinic Acid; Analysis of Variance; Cluster Analysis; Female; | 2014 |
Predictive value of intraoperative 5-aminolevulinic acid-induced fluorescence for detecting bone invasion in meningioma surgery.
Topics: Adult; Aged; Aged, 80 and over; Aminolevulinic Acid; Female; Humans; Male; Meningeal Neoplasms; Meni | 2014 |
Predictive value of intraoperative 5-aminolevulinic acid-induced fluorescence for detecting bone invasion in meningioma surgery.
Topics: Adult; Aged; Aged, 80 and over; Aminolevulinic Acid; Female; Humans; Male; Meningeal Neoplasms; Meni | 2014 |
Predictive value of intraoperative 5-aminolevulinic acid-induced fluorescence for detecting bone invasion in meningioma surgery.
Topics: Adult; Aged; Aged, 80 and over; Aminolevulinic Acid; Female; Humans; Male; Meningeal Neoplasms; Meni | 2014 |
Predictive value of intraoperative 5-aminolevulinic acid-induced fluorescence for detecting bone invasion in meningioma surgery.
Topics: Adult; Aged; Aged, 80 and over; Aminolevulinic Acid; Female; Humans; Male; Meningeal Neoplasms; Meni | 2014 |
Enhancing the effect of 5-aminolevulinic acid based photodynamic therapy in human meningioma cells.
Topics: Aminolevulinic Acid; Cell Line, Tumor; Cell Survival; Ciprofloxacin; Dose-Response Relationship, Dru | 2014 |
Usefulness of 5-ALA (Gliolan®)-derived PPX fluorescence for demonstrating the extent of infiltration in atypical meningiomas.
Topics: Adult; Aminolevulinic Acid; Female; Fluorescence; Humans; Meningeal Neoplasms; Meningioma; Photosens | 2014 |
Meningioma surgery in the era of 5-aminolevulinic acid fluorescence-guided surgery.
Topics: Aminolevulinic Acid; Female; Humans; Male; Meningeal Neoplasms; Meningioma; Skull Base Neoplasms | 2014 |
Response.
Topics: Aminolevulinic Acid; Female; Humans; Male; Meningeal Neoplasms; Meningioma; Skull Base Neoplasms | 2014 |
Aminolevulinic acid-mediated photodynamic therapy of human meningioma: an in vitro study on primary cell lines.
Topics: Adult; Aged; Aged, 80 and over; Aminolevulinic Acid; Cell Line, Tumor; Cell Survival; Dose-Response | 2015 |
Laser biospectroscopy and 5-ALA fluorescence navigation as a helpful tool in the meningioma resection.
Topics: Adult; Aged; Aminolevulinic Acid; Female; Fluorescence; Humans; Male; Meningeal Neoplasms; Meningiom | 2016 |
Intraoperative 5-aminolevulinic-acid-induced fluorescence in meningiomas.
Topics: Adult; Aged; Aminolevulinic Acid; Female; Fluorescence; Humans; Male; Meningeal Neoplasms; Meningiom | 2010 |
Comment concerning: Intraoperative 5-aminolevulinic-acid-induced fluorescence in meningiomas, Acta Neurochir DOl 1O.1007/s00701-010-0708-4, Intratumoral heterogeneity and fluorescence intensity in meningioma after 5-ALA pretreatment.
Topics: Aminolevulinic Acid; Chromosome Aberrations; Fluorescence; Genetic Heterogeneity; Humans; Intraopera | 2011 |
Confocal microscopy for the histological fluorescence pattern of a recurrent atypical meningioma: case report.
Topics: Aminolevulinic Acid; Diagnostic Imaging; Female; Fluorescent Antibody Technique; Humans; Meningeal N | 2011 |
Quantitative and qualitative 5-aminolevulinic acid-induced protoporphyrin IX fluorescence in skull base meningiomas.
Topics: Aminolevulinic Acid; Diagnostic Imaging; Female; Humans; Meningeal Neoplasms; Meningioma; Middle Age | 2011 |
Brain biopsy.
Topics: Aminolevulinic Acid; Biopsy; Brain; Brain Neoplasms; Glioma; Humans; Meningeal Neoplasms; Meningioma | 2012 |
Use of 5-aminolevulinic acid in fluorescence-guided resection of meningioma with high risk of recurrence. Case report.
Topics: Aged; Aminolevulinic Acid; Craniotomy; Female; Fluorescence; Humans; Magnetic Resonance Imaging; Men | 2007 |
Usefulness of intraoperative photodynamic diagnosis using 5-aminolevulinic acid for meningiomas with cranial invasion: technical case report.
Topics: Aged, 80 and over; Aminolevulinic Acid; Brain; Contrast Media; Female; Humans; Intraoperative Care; | 2008 |
Comparative study on the ALA photodynamic effects of human glioma and meningioma cells.
Topics: Aminolevulinic Acid; Analysis of Variance; Dose-Response Relationship, Radiation; Epidermal Growth F | 1999 |
Analysis of the surgical benefits of 5-ALA-induced fluorescence in intracranial meningiomas: experience in 204 meningiomas.
Topics: Adult; Aged; Aged, 80 and over; Aminolevulinic Acid; Brain Neoplasms; Female; Fluorescence; Humans; | 2016 |