aminolevulinic acid has been researched along with Margins of Excision in 19 studies
Aminolevulinic Acid: A compound produced from succinyl-CoA and GLYCINE as an intermediate in heme synthesis. It is used as a PHOTOCHEMOTHERAPY for actinic KERATOSIS.
5-aminolevulinic acid : The simplest delta-amino acid in which the hydrogens at the gamma position are replaced by an oxo group. It is metabolised to protoporphyrin IX, a photoactive compound which accumulates in the skin. Used (in the form of the hydrochloride salt)in combination with blue light illumination for the treatment of minimally to moderately thick actinic keratosis of the face or scalp.
Margins of Excision: The edges of tissue removed in a surgery for assessment of the effectiveness of a surgical procedure in achieving the local control of a neoplasm and the adequacy of tumor removal. When the margin is negative or not involved by tumor (e.g., CANCER) it suggests all of the tumor has been removed by the surgery.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Though meningiomas are often benign and well circumscribed in nature, many are associated with recurrences and poor outcome because of their attachment to neurovascular nearby structures or invasion of adjacent venous sinuses or bone, forcing incomplete excision and deployment of further salvage therapy." | 2.53 | ALA-induced fluorescence image guided surgery of meningiomas: A meta-analyses. ( Eljamel, S; Foster, N, 2016) |
| "ALA-FIGS in meningiomas is very selective, highly sensitive, and improves the extent of surgical resection in meningiomas." | 2.53 | ALA-induced fluorescence image guided surgery of meningiomas: A meta-analyses. ( Eljamel, S; Foster, N, 2016) |
| "FLIm measurements of resection margins presented a range of PpIX and NAD(P)H lifetime values (τPpIX ∼ 3 to 14 ns, τNAD(P)H = 3 to 6 ns) associated with unaffected tissue and areas of low-density tumor infiltration." | 1.72 | First in patient assessment of brain tumor infiltrative margins using simultaneous time-resolved measurements of 5-ALA-induced PpIX fluorescence and tissue autofluorescence. ( Alfonso-García, A; Anbunesan, SN; Bec, J; Bloch, O; Fereidouni, F; Jin, LW; Lee, HS; Marcu, L; Zhou, X, 2022) |
| " The purpose of this study was to illustrate the efficiency and safety of PDD-guided tumor excision combined with ALA-PDT in patients with extramammary Paget's disease (EMPD)." | 1.72 | PDD-guided tumor excision combined with photodynamic therapy in patients with extramammary Paget's disease. ( Kou, H; Li, X; Lu, Y; Yang, Y; Zhao, C; Zhu, F, 2022) |
| "In our study, 7 cases of EMPD were treated with PDD-guided tumor excision combined with ALA-PDT." | 1.72 | PDD-guided tumor excision combined with photodynamic therapy in patients with extramammary Paget's disease. ( Kou, H; Li, X; Lu, Y; Yang, Y; Zhao, C; Zhu, F, 2022) |
| " The adverse reactions after PDT were mild, mainly manifested as increased vaginal secretions or burning/tingling." | 1.72 | Evaluation of the efficacy and safety of 5-aminolevulinic acid-mediated photodynamic therapy in women with high-risk HPV persistent infection after cervical conization. ( Huang, Y; Jia, L; Liu, X; Liu, Y; Wang, L; Zhang, J; Zhang, Y, 2022) |
| "To evaluate the value of Wood's lamp examination combined with 5-aminolevulinic acid (5-ALA) photodynamic therapy (PDT) to determine positive tumor margins in patients with extramammary Paget's disease (EMPD) before surgery." | 1.62 | The application of Wood's lamp combined with 5-aminolevulinic acid for defining tumor margins in patients with extramammary Paget's disease. ( Fu, B; Li, J; Lou, Y; Song, C; Zhou, P, 2021) |
| " In the 5-ALA-PDT group, Wood's lamp examination combined with 5-ALA-PDT was used to trace the fluorescence range, and multipoint biopsy was performed according to the pathology to determine the final excision scope." | 1.62 | The application of Wood's lamp combined with 5-aminolevulinic acid for defining tumor margins in patients with extramammary Paget's disease. ( Fu, B; Li, J; Lou, Y; Song, C; Zhou, P, 2021) |
| "Wood's lamp examination combined with 5-ALA-PDT may predict tumor margins in EMPD." | 1.62 | The application of Wood's lamp combined with 5-aminolevulinic acid for defining tumor margins in patients with extramammary Paget's disease. ( Fu, B; Li, J; Lou, Y; Song, C; Zhou, P, 2021) |
| "Gliomas are infiltrative brain tumors with a margin difficult to identify." | 1.56 | Machine learning-based prediction of glioma margin from 5-ALA induced PpIX fluorescence spectroscopy. ( Alston, L; Brevet, PF; Frindel, C; Guyotat, J; Leclerc, P; Mahieu-Williame, L; Meyronet, D; Montcel, B; Ray, C; Rousseau, D, 2020) |
| "Initial surgical margins were determined by FD or FD plus MSB." | 1.48 | Clinical Benefits of Preoperative Conventional Fluorescence Diagnosis in Surgical Treatment of Extramammary Paget Disease. ( Chen, Z; Ma, H; Wan, M; Xie, L; Zhao, Y, 2018) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 9 (47.37) | 24.3611 |
| 2020's | 10 (52.63) | 2.80 |
| Authors | Studies |
|---|---|
| Alfonso-García, A | 1 |
| Zhou, X | 1 |
| Bec, J | 1 |
| Anbunesan, SN | 1 |
| Fereidouni, F | 1 |
| Jin, LW | 1 |
| Lee, HS | 1 |
| Bloch, O | 1 |
| Marcu, L | 1 |
| Li, X | 1 |
| Zhao, C | 1 |
| Kou, H | 1 |
| Zhu, F | 1 |
| Yang, Y | 1 |
| Lu, Y | 1 |
| Bettag, C | 1 |
| Hussein, A | 1 |
| Schatlo, B | 1 |
| Barrantes-Freer, A | 1 |
| Abboud, T | 1 |
| Rohde, V | 1 |
| Mielke, D | 1 |
| Zhang, Y | 2 |
| Su, Y | 1 |
| Tang, Y | 1 |
| Qin, L | 1 |
| Shen, Y | 1 |
| Wang, B | 1 |
| Zhou, Y | 1 |
| Zhang, M | 1 |
| Zhang, T | 1 |
| Wang, L | 1 |
| Liu, X | 1 |
| Zhang, J | 1 |
| Huang, Y | 1 |
| Liu, Y | 1 |
| Jia, L | 2 |
| Leclerc, P | 1 |
| Ray, C | 1 |
| Mahieu-Williame, L | 1 |
| Alston, L | 1 |
| Frindel, C | 1 |
| Brevet, PF | 1 |
| Meyronet, D | 1 |
| Guyotat, J | 2 |
| Montcel, B | 1 |
| Rousseau, D | 1 |
| Suero Molina, E | 1 |
| Stögbauer, L | 1 |
| Jeibmann, A | 1 |
| Warneke, N | 1 |
| Stummer, W | 1 |
| Azari, F | 1 |
| Kennedy, G | 1 |
| Bernstein, E | 1 |
| Hadjipanayis, C | 1 |
| Vahrmeijer, A | 1 |
| Smith, B | 1 |
| Rosenthal, E | 1 |
| Sumer, B | 1 |
| Tian, J | 1 |
| Henderson, E | 1 |
| Lee, A | 1 |
| Nguyen, Q | 1 |
| Gibbs, S | 1 |
| Pogue, B | 1 |
| Orringer, D | 1 |
| Charalampaki, C | 1 |
| Martin, L | 1 |
| Tanyi, J | 1 |
| Lee, M | 1 |
| Lee, JY | 1 |
| Singhal, S | 2 |
| Ottolino-Perry, K | 1 |
| Shahid, A | 1 |
| DeLuca, S | 1 |
| Son, V | 1 |
| Sukhram, M | 1 |
| Meng, F | 1 |
| Liu, ZA | 1 |
| Rapic, S | 1 |
| Anantha, NT | 1 |
| Wang, SC | 1 |
| Chamma, E | 1 |
| Gibson, C | 1 |
| Medeiros, PJ | 1 |
| Majeed, S | 1 |
| Chu, A | 1 |
| Wignall, O | 1 |
| Pizzolato, A | 1 |
| Rosen, CF | 1 |
| Teene, LL | 1 |
| Starr-Dunham, D | 1 |
| Kulbatski, I | 1 |
| Panzarella, T | 1 |
| Done, SJ | 1 |
| Easson, AM | 1 |
| Leong, WL | 1 |
| DaCosta, RS | 1 |
| Zhou, P | 1 |
| Li, J | 1 |
| Song, C | 1 |
| Lou, Y | 1 |
| Fu, B | 1 |
| Yano, H | 1 |
| Nakayama, N | 1 |
| Ohe, N | 1 |
| Miwa, K | 1 |
| Shinoda, J | 1 |
| Iwama, T | 1 |
| Wan, M | 1 |
| Ma, H | 1 |
| Zhao, Y | 1 |
| Xie, L | 1 |
| Chen, Z | 1 |
| Yagi, R | 1 |
| Kawabata, S | 1 |
| Ikeda, N | 1 |
| Nonoguchi, N | 1 |
| Furuse, M | 1 |
| Katayama, Y | 1 |
| Kajimoto, Y | 1 |
| Kuroiwa, T | 1 |
| Peng, X | 1 |
| Qian, W | 1 |
| Hou, J | 1 |
| Ross, JL | 1 |
| Cooper, LAD | 1 |
| Kong, J | 1 |
| Gutman, D | 1 |
| Williams, M | 1 |
| Tucker-Burden, C | 1 |
| McCrary, MR | 1 |
| Bouras, A | 1 |
| Kaluzova, M | 1 |
| Dunn, WD | 1 |
| Duong, D | 1 |
| Hadjipanayis, CG | 1 |
| Brat, DJ | 1 |
| Predina, JD | 1 |
| Runge, J | 1 |
| Newton, A | 1 |
| Mison, M | 1 |
| Xia, L | 1 |
| Corbett, C | 1 |
| Shin, M | 1 |
| Sulyok, LF | 1 |
| Durham, A | 1 |
| Nie, S | 1 |
| Holt, D | 1 |
| Foster, N | 1 |
| Eljamel, S | 1 |
| Eljamel, MS | 1 |
| Mahboob, SO | 1 |
| Picart, T | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| ALA-induced Fluorescence Imaging of Breast Cancers Using the Handheld PRODIGI and Eagle Imaging Devices[NCT01837225] | 90 participants (Anticipated) | Observational | 2010-09-30 | Recruiting | |||
| 5-Aminolevulinic Acid (5-ALA) Gliolan®: Usage Increase Proposal for Neurosurgical Procedures in High-Grade Gliomas[NCT05850377] | 90 participants (Anticipated) | Observational | 2023-06-01 | Not yet recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 reviews available for aminolevulinic acid and Margins of Excision
| Article | Year |
|---|---|
Intraoperative molecular imaging clinical trials: a review of 2020 conference proceedings.
Topics: Aminolevulinic Acid; Humans; Margins of Excision; Molecular Imaging; Neoplasms | 2021 |
ALA-induced fluorescence image guided surgery of meningiomas: A meta-analyses.
Topics: Aged; Aged, 80 and over; Aminolevulinic Acid; Contrast Media; Female; Fluorescent Dyes; Humans; Male | 2016 |
The effectiveness and cost-effectiveness of intraoperative imaging in high-grade glioma resection; a comparative review of intraoperative ALA, fluorescein, ultrasound and MRI.
Topics: Aminolevulinic Acid; Brain Neoplasms; Contrast Media; Cost-Benefit Analysis; Fluorescein; Glioma; He | 2016 |
1 trial available for aminolevulinic acid and Margins of Excision
| Article | Year |
|---|---|
Intraoperative fluorescence imaging with aminolevulinic acid detects grossly occult breast cancer: a phase II randomized controlled trial.
Topics: Adult; Aged; Aged, 80 and over; Aminolevulinic Acid; Biopsy; Breast Neoplasms; Contrast Media; Femal | 2021 |
15 other studies available for aminolevulinic acid and Margins of Excision
| Article | Year |
|---|---|
First in patient assessment of brain tumor infiltrative margins using simultaneous time-resolved measurements of 5-ALA-induced PpIX fluorescence and tissue autofluorescence.
Topics: Aminolevulinic Acid; Brain Neoplasms; Fluorescence; Humans; Margins of Excision; Photosensitizing Ag | 2022 |
PDD-guided tumor excision combined with photodynamic therapy in patients with extramammary Paget's disease.
Topics: Aminolevulinic Acid; Humans; Margins of Excision; Paget Disease, Extramammary; Photochemotherapy; Ph | 2022 |
Endoscope-assisted visualization of 5-aminolevulinic acid fluorescence in surgery for brain metastases.
Topics: Aminolevulinic Acid; Brain Neoplasms; Endoscopes; Humans; Margins of Excision; Retrospective Studies | 2022 |
Management of patients with positive margin after conization for high-grade cervical intraepithelial lesions.
Topics: Aminolevulinic Acid; Conization; Female; Humans; Margins of Excision; Neoplasm Recurrence, Local; Pa | 2022 |
Evaluation of the efficacy and safety of 5-aminolevulinic acid-mediated photodynamic therapy in women with high-risk HPV persistent infection after cervical conization.
Topics: Aminolevulinic Acid; Conization; Female; Human papillomavirus 16; Human papillomavirus 18; Humans; M | 2022 |
Machine learning-based prediction of glioma margin from 5-ALA induced PpIX fluorescence spectroscopy.
Topics: Aminolevulinic Acid; Biomarkers, Tumor; Brain Neoplasms; Cell Line, Tumor; Cluster Analysis; Compute | 2020 |
Validating a new generation filter system for visualizing 5-ALA-induced PpIX fluorescence in malignant glioma surgery: a proof of principle study.
Topics: Adult; Aged; Aged, 80 and over; Aminolevulinic Acid; Biopsy; Brain Neoplasms; Cell Count; Female; Fl | 2020 |
The application of Wood's lamp combined with 5-aminolevulinic acid for defining tumor margins in patients with extramammary Paget's disease.
Topics: Aminolevulinic Acid; Humans; Margins of Excision; Neoplasm Recurrence, Local; Paget Disease, Extrama | 2021 |
Pathological analysis of the surgical margins of resected glioblastomas excised using photodynamic visualization with both 5-aminolevulinic acid and fluorescein sodium.
Topics: Adult; Aged; Aminolevulinic Acid; Brain Neoplasms; Female; Fluorescein; Glioblastoma; Humans; Ki-67 | 2017 |
Clinical Benefits of Preoperative Conventional Fluorescence Diagnosis in Surgical Treatment of Extramammary Paget Disease.
Topics: Aged; Aged, 80 and over; Aminolevulinic Acid; Biopsy; Female; Fluorescence; Frozen Sections; Humans; | 2018 |
Intraoperative 5-aminolevulinic acid-induced photodynamic diagnosis of metastatic brain tumors with histopathological analysis.
Topics: Adult; Aged; Aminolevulinic Acid; Brain; Brain Neoplasms; Female; Fluorescence; Humans; Intraoperati | 2017 |
5-aminolevulinic acid (5-ALA) fluorescence-guided Mohs surgery resection of penile-scrotal extramammary Paget's disease.
Topics: Aged; Aminolevulinic Acid; Disease-Free Survival; Humans; Male; Margins of Excision; Mohs Surgery; O | 2017 |
5-Aminolevulinic Acid Guided Sampling of Glioblastoma Microenvironments Identifies Pro-Survival Signaling at Infiltrative Margins.
Topics: Adult; Aged; Aminolevulinic Acid; ErbB Receptors; Female; Fluorescence; Glioblastoma; Humans; Male; | 2017 |
Evaluation of Aminolevulinic Acid-Derived Tumor Fluorescence Yields Disparate Results in Murine and Spontaneous Large Animal Models of Lung Cancer.
Topics: Aminolevulinic Acid; Animals; Carcinoma, Non-Small-Cell Lung; Cell Line; Cell Line, Tumor; Disease M | 2019 |
[Glioblastoma, innovations in surgery].
Topics: Aminolevulinic Acid; Brain Neoplasms; Glioblastoma; Humans; Levulinic Acids; Margins of Excision; Ne | 2017 |