aminolevulinic acid has been researched along with Liver Dysfunction in 37 studies
Aminolevulinic Acid: A compound produced from succinyl-CoA and GLYCINE as an intermediate in heme synthesis. It is used as a PHOTOCHEMOTHERAPY for actinic KERATOSIS.
5-aminolevulinic acid : The simplest delta-amino acid in which the hydrogens at the gamma position are replaced by an oxo group. It is metabolised to protoporphyrin IX, a photoactive compound which accumulates in the skin. Used (in the form of the hydrochloride salt)in combination with blue light illumination for the treatment of minimally to moderately thick actinic keratosis of the face or scalp.
| Excerpt | Relevance | Reference |
|---|---|---|
| "A 43-yr-old man with abdominal fullness was treated with oral cimetidine during remission of acute intermittent porphyria." | 7.67 | Clinical usefulness of cimetidine for the treatment of acute intermittent porphyria--a preliminary report. ( Hirayama, C; Horie, Y; Udagawa, M, 1987) |
| "In two male patients with acute hepatic porphyria and persisting paralysis which increased in intensity intermittently, the activity of porphobilinogen synthase (PBG-S; delta-aminolevulinic acid dehydr(at)ase) was diminished in peripheral erythrocytes and bone marrow cells below 3% of normal controls." | 7.66 | New type of acute porphyria with porphobilinogen synthase (delta-aminolevulinic acid dehydratase) defect in the homozygous state. ( Brandt, A; Doss, M; Schneider, J; Von Tiepermann, R, 1982) |
| "Clonazepam was ineffective in treating the seizures and, in high doses, seemed to exacerbate the porphyria." | 5.26 | Seizure management in acute hepatic porphyria: risks of valproate and clonazepam. ( Bonkowsky, HL; Emery, S; Sinclair, JF; Sinclair, PR, 1980) |
| "We studied one patient with major motor seizures and acute intermittent porphyria." | 5.26 | Seizure management in acute hepatic porphyria: risks of valproate and clonazepam. ( Bonkowsky, HL; Emery, S; Sinclair, JF; Sinclair, PR, 1980) |
| "The ability of 3,5-diethoxycarbonyl-1,4-dihydrocollidine (DDC), 3,5-diethoxycarbonyl-4-ethyl-1,4-dihydro-2,6-dimethylpyridine (EDDC) and griseofulvin to induce porphyria in primary cultures of mouse hepatocytes has been examined." | 3.68 | Inhibition of ferrochelatase and accumulation of porphyrins in mouse hepatocyte cultures exposed to porphyrinogenic chemicals. ( Brady, AM; Lock, EA, 1992) |
| "A 43-yr-old man with abdominal fullness was treated with oral cimetidine during remission of acute intermittent porphyria." | 3.67 | Clinical usefulness of cimetidine for the treatment of acute intermittent porphyria--a preliminary report. ( Hirayama, C; Horie, Y; Udagawa, M, 1987) |
| "In two male patients with acute hepatic porphyria and persisting paralysis which increased in intensity intermittently, the activity of porphobilinogen synthase (PBG-S; delta-aminolevulinic acid dehydr(at)ase) was diminished in peripheral erythrocytes and bone marrow cells below 3% of normal controls." | 3.66 | New type of acute porphyria with porphobilinogen synthase (delta-aminolevulinic acid dehydratase) defect in the homozygous state. ( Brandt, A; Doss, M; Schneider, J; Von Tiepermann, R, 1982) |
| "Porphyria is making increasing demands on the attention of clinicians and research worker." | 2.36 | [Hepatic porphyria]. ( Tornaghi, G; Vitali, L, 1979) |
| "The porphyrias are caused by hereditary defects in the synthesis of heme." | 1.27 | The porphyrias. ( Rosen, T; Sekula, SA; Tschen, JA, 1986) |
| "Clonazepam was ineffective in treating the seizures and, in high doses, seemed to exacerbate the porphyria." | 1.26 | Seizure management in acute hepatic porphyria: risks of valproate and clonazepam. ( Bonkowsky, HL; Emery, S; Sinclair, JF; Sinclair, PR, 1980) |
| "We studied one patient with major motor seizures and acute intermittent porphyria." | 1.26 | Seizure management in acute hepatic porphyria: risks of valproate and clonazepam. ( Bonkowsky, HL; Emery, S; Sinclair, JF; Sinclair, PR, 1980) |
| "Antipyrine T1/2 was especially prolonged in patients with a history of more severe symptoms, but there was no correlation with the degree of elevation in urinary excretion of the porphyrin precursors delta-aminolevulinic acid (ALA) and porphobilinogen (PBG)." | 1.26 | Studies in porphyria. V. Drug oxidation rates in hereditary hepatic porphyria. ( Alvares, AP; Anderson, KE; Kappas, A; Sassa, S, 1976) |
| "Phenylbutazone T1/2s were normal in 10 porphyric patients tested." | 1.26 | Studies in porphyria. V. Drug oxidation rates in hereditary hepatic porphyria. ( Alvares, AP; Anderson, KE; Kappas, A; Sassa, S, 1976) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 32 (86.49) | 18.7374 |
| 1990's | 3 (8.11) | 18.2507 |
| 2000's | 1 (2.70) | 29.6817 |
| 2010's | 1 (2.70) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Wan, H | 1 |
| Wu, J | 1 |
| Sun, P | 1 |
| Yang, Y | 1 |
| Ibraham, NG | 1 |
| Friedland, ML | 1 |
| Levere, RD | 1 |
| Knosała, P | 1 |
| Petelenz, T | 1 |
| Zuk-Popiołek, I | 1 |
| Bonkowsky, HL | 2 |
| Schady, W | 1 |
| Sinclair, PR | 1 |
| Emery, S | 1 |
| Sinclair, JF | 1 |
| Laiwah, AC | 1 |
| Goldberg, A | 4 |
| Moore, MR | 4 |
| Romeo, G | 1 |
| Waldenström, J | 1 |
| McColl, KE | 3 |
| Wallace, AM | 2 |
| Thompson, GG | 2 |
| Day, RS | 1 |
| Eales, L | 1 |
| Doss, M | 6 |
| Schneider, J | 2 |
| Von Tiepermann, R | 2 |
| Brandt, A | 1 |
| Adam, C | 1 |
| Hassoun, A | 1 |
| Defresne, C | 1 |
| Guilmot-Bruneau, M | 1 |
| Wery-Follet, B | 1 |
| Saussez-De Temmerman, A | 1 |
| Smith, AG | 1 |
| De Matteis, F | 1 |
| Szymańska, JA | 1 |
| Piotrowski, JK | 1 |
| Becker, DM | 1 |
| Kramer, S | 2 |
| Tornaghi, G | 1 |
| Vitali, L | 1 |
| Anderson, KE | 2 |
| Fischbein, A | 1 |
| Kestenbaum, D | 1 |
| Sassa, S | 4 |
| Alvares, AP | 2 |
| Kappas, A | 2 |
| Brady, AM | 1 |
| Lock, EA | 1 |
| Deam, S | 1 |
| Elder, GH | 1 |
| Herrick, AL | 1 |
| Doss, MO | 1 |
| Frank, M | 1 |
| Bissell, DM | 1 |
| Wehmeier, A | 1 |
| Fischer, JT | 1 |
| Goerz, G | 1 |
| Schneider, W | 1 |
| Sekula, SA | 1 |
| Tschen, JA | 1 |
| Rosen, T | 1 |
| Birnie, GG | 1 |
| Brodie, MJ | 1 |
| Horie, Y | 1 |
| Udagawa, M | 1 |
| Hirayama, C | 1 |
| Sixel-Dietrich, F | 2 |
| Verspohl, F | 2 |
| Siepker, LJ | 1 |
| Zakhariia, EA | 1 |
| Temnik, IV | 1 |
| Romanishin, IaN | 1 |
| Pfändler, U | 1 |
8 reviews available for aminolevulinic acid and Liver Dysfunction
| Article | Year |
|---|---|
Heme metabolism in erythroid and hepatic cells.
Topics: 5-Aminolevulinate Synthetase; Aminolevulinic Acid; Coproporphyrinogen Oxidase; Erythrocytes; Erythro | 1983 |
Neurologic manifestations of acute porphyria.
Topics: Acute Disease; Aminolevulinic Acid; Animals; Central Nervous System; Depression; Electrophysiology; | 1982 |
The hepatic porphyrias.
Topics: 5-Aminolevulinate Synthetase; Acute Disease; Adolescent; Adult; Aminolevulinic Acid; Chemical Phenom | 1980 |
The porphyrias--a review.
Topics: Acute Disease; Aged; Alcoholism; Aminolevulinic Acid; Feces; Female; Heme; Humans; Iron; Liver Disea | 1981 |
The neurological manifestations of porphyria: a review.
Topics: Acute Disease; Aminolevulinic Acid; Animals; Heme; Humans; Liver; Liver Diseases; Nervous System; Ne | 1977 |
[Pathobiochemistry of porphyrias].
Topics: Acute Disease; Aminolevulinic Acid; Catalase; Chronic Disease; Cytochrome P-450 Enzyme System; Heme; | 1977 |
[Hepatic porphyria].
Topics: Aminolevulinic Acid; Humans; Liver; Liver Diseases; Porphyrias; Porphyrins | 1979 |
Haematological disturbances of porphyrin metabolism.
Topics: Adult; Aged; Aminolevulinic Acid; Erythropoiesis; Female; Humans; Lead Poisoning; Liver; Liver Disea | 1979 |
29 other studies available for aminolevulinic acid and Liver Dysfunction
| Article | Year |
|---|---|
Investigation of delta-aminolevulinic acid dehydratase polymorphism affecting hematopoietic, hepatic and renal toxicity from lead in Han subjects of southwestern China.
Topics: Adult; Aminolevulinic Acid; Asian People; Biomarkers; China; Creatinine; Cross-Sectional Studies; Fe | 2014 |
[A case of acute hepatic porphyria].
Topics: Acute Disease; Adult; Aminolevulinic Acid; Coproporphyrins; Humans; Liver Diseases; Male; Porphobili | 1983 |
Seizure management in acute hepatic porphyria: risks of valproate and clonazepam.
Topics: 5-Aminolevulinate Synthetase; Adult; Aminolevulinic Acid; Animals; Benzodiazepinones; Chick Embryo; | 1980 |
Pathogenesis and treatment of acute intermittent porphyria: discussion paper.
Topics: Acute Disease; Aminolevulinic Acid; Blood-Brain Barrier; Heme; Humans; Liver Diseases; Porphobilinog | 1983 |
Alterations in haem biosynthesis during the human menstrual cycle: studies in normal subjects and patients with latent and active acute intermittent porphyria.
Topics: 5-Aminolevulinate Synthetase; Adrenal Cortex Hormones; Adult; Aminolevulinic Acid; Erythrocytes; Fem | 1982 |
Acute intermittent porphyria.
Topics: Acute Disease; Aminolevulinic Acid; Humans; Levulinic Acids; Liver Diseases; Porphobilinogen; Porphy | 1982 |
New type of acute porphyria with porphobilinogen synthase (delta-aminolevulinic acid dehydratase) defect in the homozygous state.
Topics: Adult; Aminolevulinic Acid; Dithiothreitol; Enzyme Activation; Homozygote; Humans; Lead Poisoning; L | 1982 |
[Hemin treatment in a case of porphyria variegata].
Topics: Adult; Aminolevulinic Acid; Coproporphyrins; Female; Heme; Hemin; Humans; Liver Diseases; Porphobili | 1982 |
Drugs and the hepatic porphyrias.
Topics: Acetamides; Aminolevulinic Acid; Animals; Barbiturates; Cats; Dicarbethoxydihydrocollidine; Dogs; Gr | 1980 |
Acute hepatic porphyria syndrome with porphobilinogen synthase defect.
Topics: Acute Disease; Adult; Amino Acids; Aminolevulinic Acid; Erythrocytes; Feces; Female; Humans; Lead; L | 1980 |
Hepatotoxicity of monobromobenzene and hexabromobenzene: effects of repeated dosage in rats.
Topics: 5-Aminolevulinate Synthetase; Aminolevulinic Acid; Animals; Bromobenzenes; Chemical and Drug Induced | 2000 |
Plumbism from airborne lead in a firing range. An unusual exposure to a toxic heavy metal.
Topics: Adolescent; Air Pollution; Aminolevulinic Acid; Coproporphyrins; Diagnosis, Differential; Erythrocyt | 1977 |
Studies in porphyria. V. Drug oxidation rates in hereditary hepatic porphyria.
Topics: Adult; Aminolevulinic Acid; Antipyrine; Erythrocytes; Female; Half-Life; Humans; Hydroxymethylbilane | 1976 |
Inhibition of ferrochelatase and accumulation of porphyrins in mouse hepatocyte cultures exposed to porphyrinogenic chemicals.
Topics: Aminolevulinic Acid; Animals; Cells, Cultured; Chemical and Drug Induced Liver Injury; Dicarbethoxyd | 1992 |
Uroporphyria produced in mice by iron and 5-aminolevulinic acid.
Topics: Administration, Oral; Aminolevulinic Acid; Animals; Chemical and Drug Induced Liver Injury; Cytochro | 1991 |
Elevation of hormone-binding globulins in acute intermittent porphyria.
Topics: Adolescent; Adult; Aminolevulinic Acid; Arginine; Carrier Proteins; Heme; Humans; Hydrocortisone; Li | 1990 |
[Significance of delta-aminolevulinic acid synthase analysis in clinical tests].
Topics: Aminolevulinic Acid; Animals; Colorimetry; Fluorometry; Humans; Levulinic Acids; Liver; Liver Diseas | 1989 |
[Significance of delta-aminolevulinic acid analysis in clinical tests].
Topics: Amino Acid Metabolism, Inborn Errors; Aminolevulinic Acid; Chromatography, Gas; Chromatography, High | 1989 |
Hepatobiliary implications and complications in protoporphyria, a 20-year study.
Topics: Adult; Aminolevulinic Acid; Child, Preschool; Chromatography, Ion Exchange; Chromatography, Thin Lay | 1989 |
Treatment of acute hepatic porphyria with hematin.
Topics: Acute Disease; Adult; Aged; Aminolevulinic Acid; Female; Heme; Hemin; Humans; Liver Diseases; Male; | 1988 |
Polychemotherapy of acute myelogenous leukemia in a patient with acute intermittent porphyria.
Topics: Acute Disease; Adult; Aminolevulinic Acid; Antineoplastic Combined Chemotherapy Protocols; Chemical | 1987 |
The porphyrias.
Topics: Adolescent; Adult; Aminolevulinic Acid; beta Carotene; Bloodletting; Carotenoids; Child; Child, Pres | 1986 |
Antipyrine metabolism in acute hepatic porphyria in relapse and remission.
Topics: 5-Aminolevulinate Synthetase; Adolescent; Adult; Aged; Aminolevulinic Acid; Antipyrine; Cytochrome P | 1987 |
Clinical usefulness of cimetidine for the treatment of acute intermittent porphyria--a preliminary report.
Topics: 5-Aminolevulinate Synthetase; Acute Disease; Adult; Aminolevulinic Acid; Cimetidine; Humans; Liver D | 1987 |
Hyperinsulinemia in acute intermittent porphyria.
Topics: Acute Disease; Adolescent; Adult; Aminolevulinic Acid; Female; Glucose Tolerance Test; Humans; Hyper | 1985 |
Protoporphyrin accumulation by mitogen stimulated lymphocytes and protoporphyrinogen oxidase activity in patients with porphyria variegata and erythropoietic protoporphyria: evidence for deficiency of protoporphyrinogen oxidase and ferrochelatase in both
Topics: Adult; Aminolevulinic Acid; Child; Edetic Acid; Ferrochelatase; Flavoproteins; Humans; Iron; Liver D | 1985 |
[Clinical manifestations of acute intermittent porphyria (review of the literature)].
Topics: Acute Disease; Adolescent; Aminolevulinic Acid; Diagnosis, Differential; Diagnostic Errors; Female; | 1986 |
"Glucose effect" and rate limiting function of uroporphyrinogen synthase on porphyrin metabolism in hepatocyte culture: relationship with human acute hepatic porphyrias.
Topics: 5-Aminolevulinate Synthetase; Aminolevulinic Acid; Ammonia-Lyases; Animals; Cells, Cultured; Chick E | 1985 |
[Genetic prognosis of a mother with acute intermittent porphyria (hepatic form)].
Topics: Acute Disease; Adolescent; Adult; Aminolevulinic Acid; Female; Genes, Dominant; Genetic Counseling; | 1974 |