Page last updated: 2024-10-16

aminolevulinic acid and Liver Dysfunction

aminolevulinic acid has been researched along with Liver Dysfunction in 37 studies

Aminolevulinic Acid: A compound produced from succinyl-CoA and GLYCINE as an intermediate in heme synthesis. It is used as a PHOTOCHEMOTHERAPY for actinic KERATOSIS.
5-aminolevulinic acid : The simplest delta-amino acid in which the hydrogens at the gamma position are replaced by an oxo group. It is metabolised to protoporphyrin IX, a photoactive compound which accumulates in the skin. Used (in the form of the hydrochloride salt)in combination with blue light illumination for the treatment of minimally to moderately thick actinic keratosis of the face or scalp.

Research Excerpts

ExcerptRelevanceReference
"A 43-yr-old man with abdominal fullness was treated with oral cimetidine during remission of acute intermittent porphyria."7.67Clinical usefulness of cimetidine for the treatment of acute intermittent porphyria--a preliminary report. ( Hirayama, C; Horie, Y; Udagawa, M, 1987)
"In two male patients with acute hepatic porphyria and persisting paralysis which increased in intensity intermittently, the activity of porphobilinogen synthase (PBG-S; delta-aminolevulinic acid dehydr(at)ase) was diminished in peripheral erythrocytes and bone marrow cells below 3% of normal controls."7.66New type of acute porphyria with porphobilinogen synthase (delta-aminolevulinic acid dehydratase) defect in the homozygous state. ( Brandt, A; Doss, M; Schneider, J; Von Tiepermann, R, 1982)
"Clonazepam was ineffective in treating the seizures and, in high doses, seemed to exacerbate the porphyria."5.26Seizure management in acute hepatic porphyria: risks of valproate and clonazepam. ( Bonkowsky, HL; Emery, S; Sinclair, JF; Sinclair, PR, 1980)
"We studied one patient with major motor seizures and acute intermittent porphyria."5.26Seizure management in acute hepatic porphyria: risks of valproate and clonazepam. ( Bonkowsky, HL; Emery, S; Sinclair, JF; Sinclair, PR, 1980)
"The ability of 3,5-diethoxycarbonyl-1,4-dihydrocollidine (DDC), 3,5-diethoxycarbonyl-4-ethyl-1,4-dihydro-2,6-dimethylpyridine (EDDC) and griseofulvin to induce porphyria in primary cultures of mouse hepatocytes has been examined."3.68Inhibition of ferrochelatase and accumulation of porphyrins in mouse hepatocyte cultures exposed to porphyrinogenic chemicals. ( Brady, AM; Lock, EA, 1992)
"A 43-yr-old man with abdominal fullness was treated with oral cimetidine during remission of acute intermittent porphyria."3.67Clinical usefulness of cimetidine for the treatment of acute intermittent porphyria--a preliminary report. ( Hirayama, C; Horie, Y; Udagawa, M, 1987)
"In two male patients with acute hepatic porphyria and persisting paralysis which increased in intensity intermittently, the activity of porphobilinogen synthase (PBG-S; delta-aminolevulinic acid dehydr(at)ase) was diminished in peripheral erythrocytes and bone marrow cells below 3% of normal controls."3.66New type of acute porphyria with porphobilinogen synthase (delta-aminolevulinic acid dehydratase) defect in the homozygous state. ( Brandt, A; Doss, M; Schneider, J; Von Tiepermann, R, 1982)
"Porphyria is making increasing demands on the attention of clinicians and research worker."2.36[Hepatic porphyria]. ( Tornaghi, G; Vitali, L, 1979)
"The porphyrias are caused by hereditary defects in the synthesis of heme."1.27The porphyrias. ( Rosen, T; Sekula, SA; Tschen, JA, 1986)
"Clonazepam was ineffective in treating the seizures and, in high doses, seemed to exacerbate the porphyria."1.26Seizure management in acute hepatic porphyria: risks of valproate and clonazepam. ( Bonkowsky, HL; Emery, S; Sinclair, JF; Sinclair, PR, 1980)
"We studied one patient with major motor seizures and acute intermittent porphyria."1.26Seizure management in acute hepatic porphyria: risks of valproate and clonazepam. ( Bonkowsky, HL; Emery, S; Sinclair, JF; Sinclair, PR, 1980)
"Antipyrine T1/2 was especially prolonged in patients with a history of more severe symptoms, but there was no correlation with the degree of elevation in urinary excretion of the porphyrin precursors delta-aminolevulinic acid (ALA) and porphobilinogen (PBG)."1.26Studies in porphyria. V. Drug oxidation rates in hereditary hepatic porphyria. ( Alvares, AP; Anderson, KE; Kappas, A; Sassa, S, 1976)
"Phenylbutazone T1/2s were normal in 10 porphyric patients tested."1.26Studies in porphyria. V. Drug oxidation rates in hereditary hepatic porphyria. ( Alvares, AP; Anderson, KE; Kappas, A; Sassa, S, 1976)

Research

Studies (37)

TimeframeStudies, this research(%)All Research%
pre-199032 (86.49)18.7374
1990's3 (8.11)18.2507
2000's1 (2.70)29.6817
2010's1 (2.70)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Wan, H1
Wu, J1
Sun, P1
Yang, Y1
Ibraham, NG1
Friedland, ML1
Levere, RD1
Knosała, P1
Petelenz, T1
Zuk-Popiołek, I1
Bonkowsky, HL2
Schady, W1
Sinclair, PR1
Emery, S1
Sinclair, JF1
Laiwah, AC1
Goldberg, A4
Moore, MR4
Romeo, G1
Waldenström, J1
McColl, KE3
Wallace, AM2
Thompson, GG2
Day, RS1
Eales, L1
Doss, M6
Schneider, J2
Von Tiepermann, R2
Brandt, A1
Adam, C1
Hassoun, A1
Defresne, C1
Guilmot-Bruneau, M1
Wery-Follet, B1
Saussez-De Temmerman, A1
Smith, AG1
De Matteis, F1
Szymańska, JA1
Piotrowski, JK1
Becker, DM1
Kramer, S2
Tornaghi, G1
Vitali, L1
Anderson, KE2
Fischbein, A1
Kestenbaum, D1
Sassa, S4
Alvares, AP2
Kappas, A2
Brady, AM1
Lock, EA1
Deam, S1
Elder, GH1
Herrick, AL1
Doss, MO1
Frank, M1
Bissell, DM1
Wehmeier, A1
Fischer, JT1
Goerz, G1
Schneider, W1
Sekula, SA1
Tschen, JA1
Rosen, T1
Birnie, GG1
Brodie, MJ1
Horie, Y1
Udagawa, M1
Hirayama, C1
Sixel-Dietrich, F2
Verspohl, F2
Siepker, LJ1
Zakhariia, EA1
Temnik, IV1
Romanishin, IaN1
Pfändler, U1

Reviews

8 reviews available for aminolevulinic acid and Liver Dysfunction

ArticleYear
Heme metabolism in erythroid and hepatic cells.
    Progress in hematology, 1983, Volume: 13

    Topics: 5-Aminolevulinate Synthetase; Aminolevulinic Acid; Coproporphyrinogen Oxidase; Erythrocytes; Erythro

1983
Neurologic manifestations of acute porphyria.
    Seminars in liver disease, 1982, Volume: 2, Issue:2

    Topics: Acute Disease; Aminolevulinic Acid; Animals; Central Nervous System; Depression; Electrophysiology;

1982
The hepatic porphyrias.
    Progress in medical genetics, 1980, Volume: 4

    Topics: 5-Aminolevulinate Synthetase; Acute Disease; Adolescent; Adult; Aminolevulinic Acid; Chemical Phenom

1980
The porphyrias--a review.
    Haematologia, 1981, Volume: 14, Issue:3

    Topics: Acute Disease; Aged; Alcoholism; Aminolevulinic Acid; Feces; Female; Heme; Humans; Iron; Liver Disea

1981
The neurological manifestations of porphyria: a review.
    Medicine, 1977, Volume: 56, Issue:5

    Topics: Acute Disease; Aminolevulinic Acid; Animals; Heme; Humans; Liver; Liver Diseases; Nervous System; Ne

1977
[Pathobiochemistry of porphyrias].
    Medizinische Klinik, 1977, Sep-23, Volume: 72, Issue:38

    Topics: Acute Disease; Aminolevulinic Acid; Catalase; Chronic Disease; Cytochrome P-450 Enzyme System; Heme;

1977
[Hepatic porphyria].
    Minerva medica, 1979, Mar-10, Volume: 70, Issue:12

    Topics: Aminolevulinic Acid; Humans; Liver; Liver Diseases; Porphyrias; Porphyrins

1979
Haematological disturbances of porphyrin metabolism.
    Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer, 1979, Volume: 69

    Topics: Adult; Aged; Aminolevulinic Acid; Erythropoiesis; Female; Humans; Lead Poisoning; Liver; Liver Disea

1979

Other Studies

29 other studies available for aminolevulinic acid and Liver Dysfunction

ArticleYear
Investigation of delta-aminolevulinic acid dehydratase polymorphism affecting hematopoietic, hepatic and renal toxicity from lead in Han subjects of southwestern China.
    Acta physiologica Hungarica, 2014, Volume: 101, Issue:1

    Topics: Adult; Aminolevulinic Acid; Asian People; Biomarkers; China; Creatinine; Cross-Sectional Studies; Fe

2014
[A case of acute hepatic porphyria].
    Wiadomosci lekarskie (Warsaw, Poland : 1960), 1983, Nov-15, Volume: 36, Issue:22

    Topics: Acute Disease; Adult; Aminolevulinic Acid; Coproporphyrins; Humans; Liver Diseases; Male; Porphobili

1983
Seizure management in acute hepatic porphyria: risks of valproate and clonazepam.
    Neurology, 1980, Volume: 30, Issue:6

    Topics: 5-Aminolevulinate Synthetase; Adult; Aminolevulinic Acid; Animals; Benzodiazepinones; Chick Embryo;

1980
Pathogenesis and treatment of acute intermittent porphyria: discussion paper.
    Journal of the Royal Society of Medicine, 1983, Volume: 76, Issue:5

    Topics: Acute Disease; Aminolevulinic Acid; Blood-Brain Barrier; Heme; Humans; Liver Diseases; Porphobilinog

1983
Alterations in haem biosynthesis during the human menstrual cycle: studies in normal subjects and patients with latent and active acute intermittent porphyria.
    Clinical science (London, England : 1979), 1982, Volume: 62, Issue:2

    Topics: 5-Aminolevulinate Synthetase; Adrenal Cortex Hormones; Adult; Aminolevulinic Acid; Erythrocytes; Fem

1982
Acute intermittent porphyria.
    South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde, 1982, Feb-20, Volume: 61, Issue:8

    Topics: Acute Disease; Aminolevulinic Acid; Humans; Levulinic Acids; Liver Diseases; Porphobilinogen; Porphy

1982
New type of acute porphyria with porphobilinogen synthase (delta-aminolevulinic acid dehydratase) defect in the homozygous state.
    Clinical biochemistry, 1982, Volume: 15, Issue:1

    Topics: Adult; Aminolevulinic Acid; Dithiothreitol; Enzyme Activation; Homozygote; Humans; Lead Poisoning; L

1982
[Hemin treatment in a case of porphyria variegata].
    Dermatologica, 1982, Volume: 165, Issue:6

    Topics: Adult; Aminolevulinic Acid; Coproporphyrins; Female; Heme; Hemin; Humans; Liver Diseases; Porphobili

1982
Drugs and the hepatic porphyrias.
    Clinics in haematology, 1980, Volume: 9, Issue:2

    Topics: Acetamides; Aminolevulinic Acid; Animals; Barbiturates; Cats; Dicarbethoxydihydrocollidine; Dogs; Gr

1980
Acute hepatic porphyria syndrome with porphobilinogen synthase defect.
    The International journal of biochemistry, 1980, Volume: 12, Issue:5-6

    Topics: Acute Disease; Adult; Amino Acids; Aminolevulinic Acid; Erythrocytes; Feces; Female; Humans; Lead; L

1980
Hepatotoxicity of monobromobenzene and hexabromobenzene: effects of repeated dosage in rats.
    Chemosphere, 2000, Volume: 41, Issue:10

    Topics: 5-Aminolevulinate Synthetase; Aminolevulinic Acid; Animals; Bromobenzenes; Chemical and Drug Induced

2000
Plumbism from airborne lead in a firing range. An unusual exposure to a toxic heavy metal.
    The American journal of medicine, 1977, Volume: 63, Issue:2

    Topics: Adolescent; Air Pollution; Aminolevulinic Acid; Coproporphyrins; Diagnosis, Differential; Erythrocyt

1977
Studies in porphyria. V. Drug oxidation rates in hereditary hepatic porphyria.
    Clinical pharmacology and therapeutics, 1976, Volume: 19, Issue:1

    Topics: Adult; Aminolevulinic Acid; Antipyrine; Erythrocytes; Female; Half-Life; Humans; Hydroxymethylbilane

1976
Inhibition of ferrochelatase and accumulation of porphyrins in mouse hepatocyte cultures exposed to porphyrinogenic chemicals.
    Archives of toxicology, 1992, Volume: 66, Issue:3

    Topics: Aminolevulinic Acid; Animals; Cells, Cultured; Chemical and Drug Induced Liver Injury; Dicarbethoxyd

1992
Uroporphyria produced in mice by iron and 5-aminolevulinic acid.
    Biochemical pharmacology, 1991, Jun-15, Volume: 41, Issue:12

    Topics: Administration, Oral; Aminolevulinic Acid; Animals; Chemical and Drug Induced Liver Injury; Cytochro

1991
Elevation of hormone-binding globulins in acute intermittent porphyria.
    Clinica chimica acta; international journal of clinical chemistry, 1990, Feb-28, Volume: 187, Issue:2

    Topics: Adolescent; Adult; Aminolevulinic Acid; Arginine; Carrier Proteins; Heme; Humans; Hydrocortisone; Li

1990
[Significance of delta-aminolevulinic acid synthase analysis in clinical tests].
    Nihon rinsho. Japanese journal of clinical medicine, 1989, Volume: 48 Suppl

    Topics: Aminolevulinic Acid; Animals; Colorimetry; Fluorometry; Humans; Levulinic Acids; Liver; Liver Diseas

1989
[Significance of delta-aminolevulinic acid analysis in clinical tests].
    Nihon rinsho. Japanese journal of clinical medicine, 1989, Volume: 48 Suppl

    Topics: Amino Acid Metabolism, Inborn Errors; Aminolevulinic Acid; Chromatography, Gas; Chromatography, High

1989
Hepatobiliary implications and complications in protoporphyria, a 20-year study.
    Clinical biochemistry, 1989, Volume: 22, Issue:3

    Topics: Adult; Aminolevulinic Acid; Child, Preschool; Chromatography, Ion Exchange; Chromatography, Thin Lay

1989
Treatment of acute hepatic porphyria with hematin.
    Journal of hepatology, 1988, Volume: 6, Issue:1

    Topics: Acute Disease; Adult; Aged; Aminolevulinic Acid; Female; Heme; Hemin; Humans; Liver Diseases; Male;

1988
Polychemotherapy of acute myelogenous leukemia in a patient with acute intermittent porphyria.
    Klinische Wochenschrift, 1987, Apr-01, Volume: 65, Issue:7

    Topics: Acute Disease; Adult; Aminolevulinic Acid; Antineoplastic Combined Chemotherapy Protocols; Chemical

1987
The porphyrias.
    American family physician, 1986, Volume: 33, Issue:3

    Topics: Adolescent; Adult; Aminolevulinic Acid; beta Carotene; Bloodletting; Carotenoids; Child; Child, Pres

1986
Antipyrine metabolism in acute hepatic porphyria in relapse and remission.
    British journal of clinical pharmacology, 1987, Volume: 23, Issue:3

    Topics: 5-Aminolevulinate Synthetase; Adolescent; Adult; Aged; Aminolevulinic Acid; Antipyrine; Cytochrome P

1987
Clinical usefulness of cimetidine for the treatment of acute intermittent porphyria--a preliminary report.
    Clinica chimica acta; international journal of clinical chemistry, 1987, Aug-31, Volume: 167, Issue:3

    Topics: 5-Aminolevulinate Synthetase; Acute Disease; Adult; Aminolevulinic Acid; Cimetidine; Humans; Liver D

1987
Hyperinsulinemia in acute intermittent porphyria.
    Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme, 1985, Volume: 17, Issue:7

    Topics: Acute Disease; Adolescent; Adult; Aminolevulinic Acid; Female; Glucose Tolerance Test; Humans; Hyper

1985
Protoporphyrin accumulation by mitogen stimulated lymphocytes and protoporphyrinogen oxidase activity in patients with porphyria variegata and erythropoietic protoporphyria: evidence for deficiency of protoporphyrinogen oxidase and ferrochelatase in both
    British journal of haematology, 1985, Volume: 60, Issue:1

    Topics: Adult; Aminolevulinic Acid; Child; Edetic Acid; Ferrochelatase; Flavoproteins; Humans; Iron; Liver D

1985
[Clinical manifestations of acute intermittent porphyria (review of the literature)].
    Vrachebnoe delo, 1986, Issue:1

    Topics: Acute Disease; Adolescent; Aminolevulinic Acid; Diagnosis, Differential; Diagnostic Errors; Female;

1986
"Glucose effect" and rate limiting function of uroporphyrinogen synthase on porphyrin metabolism in hepatocyte culture: relationship with human acute hepatic porphyrias.
    Journal of clinical chemistry and clinical biochemistry. Zeitschrift fur klinische Chemie und klinische Biochemie, 1985, Volume: 23, Issue:9

    Topics: 5-Aminolevulinate Synthetase; Aminolevulinic Acid; Ammonia-Lyases; Animals; Cells, Cultured; Chick E

1985
[Genetic prognosis of a mother with acute intermittent porphyria (hepatic form)].
    Journal de genetique humaine, 1974, Volume: 22, Issue:2

    Topics: Acute Disease; Adolescent; Adult; Aminolevulinic Acid; Female; Genes, Dominant; Genetic Counseling;

1974