aminolevulinic acid has been researched along with Leukemia in 15 studies
Aminolevulinic Acid: A compound produced from succinyl-CoA and GLYCINE as an intermediate in heme synthesis. It is used as a PHOTOCHEMOTHERAPY for actinic KERATOSIS.
5-aminolevulinic acid : The simplest delta-amino acid in which the hydrogens at the gamma position are replaced by an oxo group. It is metabolised to protoporphyrin IX, a photoactive compound which accumulates in the skin. Used (in the form of the hydrochloride salt)in combination with blue light illumination for the treatment of minimally to moderately thick actinic keratosis of the face or scalp.
Leukemia: A progressive, malignant disease of the blood-forming organs, characterized by distorted proliferation and development of leukocytes and their precursors in the blood and bone marrow. Leukemias were originally termed acute or chronic based on life expectancy but now are classified according to cellular maturity. Acute leukemias consist of predominately immature cells; chronic leukemias are composed of more mature cells. (From The Merck Manual, 2006)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Ellagic acid (EA) is a naturally phenolic acid presented in different foods." | 5.48 | The effect of ellagic acid on photodynamic therapy in leukemia cells. ( Li, Y; Lu, Y; Sun, D; Wang, KG; Zhang, SJ, 2018) |
| "Human adenocarcinoma cells of the line WiDr and human leukemia T cells of the line Jurkat were incubated with 5-aminolevulinic acid and found to produce protoporphyrin IX (PpIX)." | 3.71 | Transfer of protoporphyrin IX between cells. ( Ma, LW; Moan, J; Stokke, T, 2002) |
| "To verify if photodynamic therapy (PDT) could overcome multidrug resistance (MDR) when it it applied to eradicate minimal residual disease in patients with leukemia, we investigated the fluorescence kinetics of 5-aminolaevulinic acid (ALA)-induced protoporphyrin IX (PpIX) and the effect of subsequent photodynamic therapy on MDR leukemia cells, which express P-glycoprotein (P-gp), as well as on their parent cells." | 3.71 | 5-Aminolaevulinic acid-mediated photodynamic therapy in multidrug resistant leukemia cells. ( Hashimoto, K; Li, W; Ohnishi, K; Ohno, R; Yamada, I; Zhang, WJ, 2001) |
| "Biosynthesis of porphyrins in erythrocytes after incubation with delta-aminolevulinic acid was studied by the method of IDELSON in a control group of 30 healthy males and females as well as in 13 patients (7 females and 6 males) followed up during the initial stage, in remission and relapse of acute leukemia." | 3.66 | Studies on porphyrin biosynthesis in erythrocytes after incubation with delta-aminolaevulinic acid in patients with acute leukemia. ( Arsov, T; Ivanov, E, 1981) |
| "Ellagic acid (EA) is a naturally phenolic acid presented in different foods." | 1.48 | The effect of ellagic acid on photodynamic therapy in leukemia cells. ( Li, Y; Lu, Y; Sun, D; Wang, KG; Zhang, SJ, 2018) |
| "Assessment of phototoxicity of PDT using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay showed that PDT was effective in NB4, NB4/MDR, NOMO-1 and NOMO-1/ADR cells, which accumulated high levels of PpIX, but not effective in K562 and K562/ADR cell lines, which accumulated relatively low levels of PpIX." | 1.31 | 5-Aminolaevulinic acid-mediated photodynamic therapy in multidrug resistant leukemia cells. ( Hashimoto, K; Li, W; Ohnishi, K; Ohno, R; Yamada, I; Zhang, WJ, 2001) |
| "Thymidine incorporation was inhibited by the photodynamic effect depending on porphyrin concentration." | 1.28 | Inactivation of erythrocytic, lymphocytic and myelocytic leukemic cells by photoexcitation of endogenous porphyrins. ( Ehrenberg, B; Faraggi, A; Malik, Z, 1989) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (26.67) | 18.7374 |
| 1990's | 1 (6.67) | 18.2507 |
| 2000's | 8 (53.33) | 29.6817 |
| 2010's | 2 (13.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Sun, D | 1 |
| Lu, Y | 1 |
| Zhang, SJ | 1 |
| Wang, KG | 1 |
| Li, Y | 1 |
| Diez, B | 2 |
| Cordo Russo, R | 1 |
| Teijo, MJ | 2 |
| Hajos, S | 2 |
| Batlle, A | 2 |
| Fukuda, H | 2 |
| Ernst, G | 1 |
| Moan, J | 1 |
| Ma, LW | 1 |
| Stokke, T | 1 |
| Smetana, K | 2 |
| Hrkal, Z | 5 |
| SCHLENKER, FS | 1 |
| TAYLOR, NA | 1 |
| KIEHN, BP | 1 |
| Arsov, T | 1 |
| Ivanov, E | 2 |
| Arsov, Ts | 1 |
| Gekova, K | 1 |
| Grebenová, D | 2 |
| Cajthamlová, H | 3 |
| Bartosová, J | 2 |
| Marinov, J | 1 |
| Klamová, H | 1 |
| Fuchs, O | 1 |
| Belicková, M | 1 |
| Bruchová, H | 1 |
| Brdicka, R | 1 |
| Rebeiz, N | 1 |
| Arkins, S | 1 |
| Kelley, KW | 1 |
| Durack, G | 1 |
| Rebeiz, CA | 1 |
| Li, W | 1 |
| Zhang, WJ | 1 |
| Ohnishi, K | 1 |
| Yamada, I | 1 |
| Ohno, R | 1 |
| Hashimoto, K | 1 |
| Malik, Z | 1 |
| Ehrenberg, B | 1 |
| Faraggi, A | 1 |
15 other studies available for aminolevulinic acid and Leukemia
| Article | Year |
|---|---|
The effect of ellagic acid on photodynamic therapy in leukemia cells.
Topics: Aminolevulinic Acid; Cell Survival; DNA Damage; Ellagic Acid; Humans; K562 Cells; Leukemia; Lipid Pe | 2018 |
Ros production by endogenously generated Protoporphyrin IX in murine leukemia cells.
Topics: Aminolevulinic Acid; Animals; Apoptosis; Cell Line, Tumor; Drug Resistance, Neoplasm; Leukemia; Memb | 2009 |
Combined chemotherapy and ALA-based photodynamic therapy in leukemic murine cells.
Topics: Aminolevulinic Acid; Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Cell Death; | 2012 |
Transfer of protoporphyrin IX between cells.
Topics: Adenocarcinoma; Aminolevulinic Acid; Cell Communication; Cell Line, Tumor; Colonic Neoplasms; Humans | 2002 |
Nucleoli in large (giant) bi- and multinucleate cells after apoptosis-inducing photodynamic treatment.
Topics: Aminolevulinic Acid; Apoptosis; Cell Nucleolus; Cell Survival; Giant Cells; Granulocytes; HL-60 Cell | 2003 |
THE CHROMATOGRAPHIC SEPARATION, DETERMINATION, AND DAILY EXCRETION OF URINARY PORPHOBILINOGEN, AMINO ACETONE, AND DELTA-AMINOLEVULINIC ACID.
Topics: Acetone; Aminolevulinic Acid; Anemia; Anemia, Sickle Cell; Chromatography; Fluids and Secretions; Ho | 1964 |
Studies on porphyrin biosynthesis in erythrocytes after incubation with delta-aminolaevulinic acid in patients with acute leukemia.
Topics: Adult; Aminolevulinic Acid; Anemia; Erythrocytes; Female; Humans; Leukemia; Levulinic Acids; Male; M | 1981 |
[Urinary and fecal excretion of porphyrins and their precursors in leukemia patients].
Topics: Acute Disease; Adolescent; Adult; Aged; Aminolevulinic Acid; Coproporphyrins; Feces; Female; Humans; | 1983 |
Selective destruction of leukaemic cells by photo-activation of 5-aminolaevulinic acid-induced protoporphyrin-IX.
Topics: Aminolevulinic Acid; Bone Marrow Cells; Cell Division; Cell Survival; Hematopoietic Stem Cells; HL-6 | 1998 |
Genes involved in the destruction of leukaemic cells by induced photosensitivity.
Topics: Aminolevulinic Acid; Apoptosis; Cell Survival; DNA, Complementary; Gene Expression Profiling; Gene E | 2000 |
Accumulation of protoporphyrin-IX (PpIX) in leukemic cell lines following induction by 5-aminolevulinic acid (ALA).
Topics: Aminolevulinic Acid; Animals; Cattle; Culture Media; Ferrochelatase; HL-60 Cells; Humans; Jurkat Cel | 2000 |
The 5-aminolaevulinic acid-based photodynamic effects on nuclei and nucleoli of HL-60 leukemic granulocytic precursors.
Topics: Aminolevulinic Acid; Apoptosis; Cell Division; Cell Nucleolus; Cell Nucleus; Chromatin; DNA; Eosine | 2000 |
Modulator of heme biosynthesis induces apoptosis in leukemia cells.
Topics: Aminolevulinic Acid; Animals; Apoptosis; Cell Cycle; Cell Division; Cell Membrane Permeability; Cell | 2001 |
5-Aminolaevulinic acid-mediated photodynamic therapy in multidrug resistant leukemia cells.
Topics: Aminolevulinic Acid; Apoptosis; ATP Binding Cassette Transporter, Subfamily B, Member 1; Dermatitis, | 2001 |
Inactivation of erythrocytic, lymphocytic and myelocytic leukemic cells by photoexcitation of endogenous porphyrins.
Topics: Aminolevulinic Acid; Animals; Cell Survival; Humans; Leukemia; Leukemia, Erythroblastic, Acute; Leuk | 1989 |