Page last updated: 2024-10-16

aminolevulinic acid and Laryngeal Neoplasms

aminolevulinic acid has been researched along with Laryngeal Neoplasms in 19 studies

Aminolevulinic Acid: A compound produced from succinyl-CoA and GLYCINE as an intermediate in heme synthesis. It is used as a PHOTOCHEMOTHERAPY for actinic KERATOSIS.
5-aminolevulinic acid : The simplest delta-amino acid in which the hydrogens at the gamma position are replaced by an oxo group. It is metabolised to protoporphyrin IX, a photoactive compound which accumulates in the skin. Used (in the form of the hydrochloride salt)in combination with blue light illumination for the treatment of minimally to moderately thick actinic keratosis of the face or scalp.

Laryngeal Neoplasms: Cancers or tumors of the LARYNX or any of its parts: the GLOTTIS; EPIGLOTTIS; LARYNGEAL CARTILAGES; LARYNGEAL MUSCLES; and VOCAL CORDS.

Research Excerpts

ExcerptRelevanceReference
"To explore the therapeutic effect of topical 5-Aminolevulinic Acid photodynamic therapy (ALA-PDT) on laryngeal papillomatosis (LP) treatment."7.91Topical 5-aminolevulinic acid photodynamic therapy for laryngeal papillomatosistosis treatment. ( Cai, Q; Chen, R; Han, P; Huang, X; Liang, F; Lin, P; Luo, M, 2019)
"The detection rate of HPV infections was 76."5.51Topical 5-aminolevulinic acid photodynamic therapy for laryngeal papillomatosistosis treatment. ( Cai, Q; Chen, R; Han, P; Huang, X; Liang, F; Lin, P; Luo, M, 2019)
"To explore the therapeutic effect of topical 5-Aminolevulinic Acid photodynamic therapy (ALA-PDT) on laryngeal papillomatosis (LP) treatment."3.91Topical 5-aminolevulinic acid photodynamic therapy for laryngeal papillomatosistosis treatment. ( Cai, Q; Chen, R; Han, P; Huang, X; Liang, F; Lin, P; Luo, M, 2019)
"Laryngeal lesions (N = 39; 21 after administration of delta-aminolevulinic acid (ALA)) were investigated with laser-induced fluorescence, and the results correlated to histopathologic grading in 4 groups: non/mild dysplasia (I), moderate dysplasia (II), severe dysplasia/cancer in situ (III), and carcinoma."3.74Fluorescence investigations to classify malignant laryngeal lesions in vivo. ( Andersson-Engels, S; Eker, C; Krogdahl, A; Rydell, R; Svanberg, K; Wahlberg, P, 2008)
"Patients with laryngeal cancer (or a history of laryngeal cancer), leukoplakia previously treated with radiation and no pathologic report were excluded."1.72Long-term outcomes of aminolevulinic acid photodynamic therapy for treatment of recalcitrant laryngeal premalignant lesions. ( Franco, RA; Santeerapharp, A; Song, SA; Woo, P, 2022)
"The detection rate of HPV infections was 76."1.51Topical 5-aminolevulinic acid photodynamic therapy for laryngeal papillomatosistosis treatment. ( Cai, Q; Chen, R; Han, P; Huang, X; Liang, F; Lin, P; Luo, M, 2019)
"This article describes the case of 5-Aminolevulinic Acid Photodynamic Therapy (ALA-PDT) via self-retaining laryngoscope under general anesthesia combined with CO2 Laser Therapy in the treatment of three patients with juvenile laryngeal papilloma."1.435-Aminolevulinic Acid Photodynamic Therapy combined with CO2 laser therapy in treatment of laryngeal papilloma: Case report. ( Huang, Z; Yang, Y; Zhang, Y; Zou, X, 2016)
"Early diagnosis of laryngeal cancer and its precursor lesions is simplified."1.34Indirect fluorescence laryngoscopy in the diagnosis of precancerous and cancerous laryngeal lesions. ( Arens, C; Betz, CS; Glanz, H; Leunig, A; Reussner, D; Woenkhaus, J, 2007)
"It will be the aim of further investigations to verify the optimal time of incubation and dosing of systemical 5-ALA application to enhance fluorescence contrasts and set the basis for fluorescence guided resections."1.31[Fluorescence staining of oral and laryngeal cancer after application of 5-aminolevulinic acid]. ( Baumgartner, R; Betz, CS; Heinrich, P; Janda, P; Leunig, A, 2002)

Research

Studies (19)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's3 (15.79)18.2507
2000's10 (52.63)29.6817
2010's4 (21.05)24.3611
2020's2 (10.53)2.80

Authors

AuthorsStudies
Santeerapharp, A1
Song, SA1
Woo, P1
Franco, RA2
Liang, F1
Han, P1
Chen, R1
Lin, P1
Luo, M1
Cai, Q1
Huang, X1
Alekseeva, PM1
Efendiev, KT1
Shiryaev, AA1
Rusakov, MA1
Simonova, MS1
Samoylova, SI1
Fatyanova, AS1
Reshetov, IV1
Loschenov, VB1
Zhang, Y1
Yang, Y1
Zou, X1
Huang, Z1
Alvarez, MG1
Milanesio, M1
Rivarola, V1
Durantini, E1
Batlle, A1
Fukuda, H1
Hughes, OR1
Stone, N1
Kraft, M2
Arens, C4
Birchall, MA1
Betz, CS5
Leunig, A5
Heinrich, P1
Janda, P1
Baumgartner, R3
Csanády, M1
Kiss, JG1
Iván, L1
Jóri, J1
Czigner, J1
Zenzen, V1
Zankl, H1
Reussner, D1
Woenkhaus, J1
Glanz, H1
Rydell, R1
Eker, C1
Andersson-Engels, S1
Krogdahl, A1
Wahlberg, P1
Svanberg, K1
Kleemann, D1
MacRobert, AJ1
Mentzel, T1
Brown, SG1
Mehlmann, M2
Stepp, H2
Arbogast, S2
Grevers, G2
Malczewski, M1
Birecki, J1
Symonowicz, K1
Bronowicz, A1
Ziółkowski, P1
Rabczyński, J1
Barańska, K1
Marszalik, P1
Sieron, A1
Namyslowski, G1
Misiolek, M1
Adamek, M1
Kawczyk-Krupka, A1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Clinical Validation of High Throughput Raman Fiber Optic Probe to Determine Hepatic Fat Content[NCT02621853]Phase 225 participants (Anticipated)Interventional2016-01-31Not yet recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

2 reviews available for aminolevulinic acid and Laryngeal Neoplasms

ArticleYear
Optical and molecular techniques to identify tumor margins within the larynx.
    Head & neck, 2010, Volume: 32, Issue:11

    Topics: Aminolevulinic Acid; Fluorescence; Humans; Laryngeal Mucosa; Laryngeal Neoplasms; Laryngoscopy; Lary

2010
Value of fluorescence endoscopy for the early diagnosis of laryngeal cancer and its precursor lesions.
    Head & neck, 2011, Volume: 33, Issue:7

    Topics: Aminolevulinic Acid; Carcinoma, Squamous Cell; Early Detection of Cancer; Endoscopy; Fluorescence; H

2011

Other Studies

17 other studies available for aminolevulinic acid and Laryngeal Neoplasms

ArticleYear
Long-term outcomes of aminolevulinic acid photodynamic therapy for treatment of recalcitrant laryngeal premalignant lesions.
    Clinical otolaryngology : official journal of ENT-UK ; official journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery, 2022, Volume: 47, Issue:1

    Topics: Aged; Aminolevulinic Acid; Case-Control Studies; Female; Humans; Laryngeal Neoplasms; Laser Therapy;

2022
Topical 5-aminolevulinic acid photodynamic therapy for laryngeal papillomatosistosis treatment.
    Photodiagnosis and photodynamic therapy, 2019, Volume: 28

    Topics: Administration, Topical; Adult; Aminolevulinic Acid; Child; Child, Preschool; Female; Humans; Infant

2019
Sublingual administration of 5-aminolevulinic acid for laser-induced photodiagnostics and photodynamic therapy of oral cavity and larynx cancers.
    Photodiagnosis and photodynamic therapy, 2021, Volume: 34

    Topics: Administration, Sublingual; Aminolevulinic Acid; Humans; Laryngeal Neoplasms; Lasers; Mouth; Photoch

2021
5-Aminolevulinic Acid Photodynamic Therapy combined with CO2 laser therapy in treatment of laryngeal papilloma: Case report.
    Photodiagnosis and photodynamic therapy, 2016, Volume: 14

    Topics: Aminolevulinic Acid; Child; Child, Preschool; Female; Humans; Laryngeal Neoplasms; Lasers, Gas; Male

2016
Endogenous and exogenous porphyrins as photosensitizers in the Hep-2 human carcinoma cell line.
    Cellular and molecular biology (Noisy-le-Grand, France), 2009, Jul-01, Volume: 55, Issue:2

    Topics: Aminolevulinic Acid; Carcinoma; Cell Line, Tumor; Cell Survival; Fullerenes; Humans; Laryngeal Neopl

2009
[Fluorescence staining of oral and laryngeal cancer after application of 5-aminolevulinic acid].
    Laryngo- rhino- otologie, 2002, Volume: 81, Issue:11

    Topics: Administration, Inhalation; Administration, Oral; Aminolevulinic Acid; Biopsy; Carcinoma, Squamous C

2002
ALA (5-aminolevulinic acid)-induced protoporphyrin IX fluorescence in the endoscopic diagnostic and control of pharyngo-laryngeal cancer.
    European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery, 2004, Volume: 261, Issue:5

    Topics: Adult; Aged; Aminolevulinic Acid; Diagnosis, Differential; Female; Fluorescence; Humans; Laryngeal N

2004
Protoporphyrin IX-accumulation in human tumor cells following topical ALA- and h-ALA-application in vivo.
    Cancer letters, 2003, Dec-08, Volume: 202, Issue:1

    Topics: Administration, Topical; Allantois; Aminolevulinic Acid; Animals; Chick Embryo; Female; Humans; Lary

2003
[Early diagnosis of laryngeal cancer].
    Laryngo- rhino- otologie, 2004, Volume: 83, Issue:11

    Topics: Aminolevulinic Acid; Diagnosis, Differential; Early Diagnosis; Fluorescence; Humans; Laryngeal Neopl

2004
Indirect fluorescence laryngoscopy in the diagnosis of precancerous and cancerous laryngeal lesions.
    European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery, 2007, Volume: 264, Issue:6

    Topics: Aminolevulinic Acid; Diagnosis, Differential; Fluorescence; Humans; Hyperplasia; Laryngeal Diseases;

2007
Aminolevulinic acid 585 nm pulsed dye laser photodynamic treatment of laryngeal keratosis with atypia.
    Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery, 2007, Volume: 136, Issue:6

    Topics: Administration, Topical; Aged; Ambulatory Care; Aminolevulinic Acid; Biopsy; Cell Transformation, Ne

2007
Fluorescence investigations to classify malignant laryngeal lesions in vivo.
    Head & neck, 2008, Volume: 30, Issue:4

    Topics: Adult; Aged; Aged, 80 and over; Aminolevulinic Acid; Biopsy; Carcinoma; Female; Humans; Laryngeal Ne

2008
Experimental photodynamic therapy of the larynx using 5-aminolaevulinic acid.
    Advances in oto-rhino-laryngology, 1995, Volume: 49

    Topics: Aminolevulinic Acid; Animals; Carcinoma, Squamous Cell; Dose-Response Relationship, Drug; Injections

1995
Fluorescence staining of laryngeal neoplasms after topical application of 5-aminolevulinic acid: preliminary results.
    Lasers in surgery and medicine, 1999, Volume: 25, Issue:5

    Topics: Administration, Topical; Aminolevulinic Acid; Biopsy; Evaluation Studies as Topic; Humans; Laryngeal

1999
[Clinical applications of photodynamic therapy in the treatment of laryngeal lesions].
    Otolaryngologia polska = The Polish otolaryngology, 1999, Volume: 53, Issue:6

    Topics: Adult; Aminolevulinic Acid; Humans; Laryngeal Neoplasms; Leukoplakia; Middle Aged; Photochemotherapy

1999
A pilot series demonstrating fluorescence staining of laryngeal papilloma using 5-aminolevulinic acid.
    The Laryngoscope, 2000, Volume: 110, Issue:10 Pt 1

    Topics: Administration, Topical; Adult; Aminolevulinic Acid; Female; Fluorescent Dyes; Humans; Laryngeal Neo

2000
Photodynamic therapy of premalignant lesions and local recurrence of laryngeal and hypopharyngeal cancers.
    European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery, 2001, Volume: 258, Issue:7

    Topics: Aminolevulinic Acid; Carcinoma, Squamous Cell; Female; Humans; Hypopharyngeal Neoplasms; Laryngeal N

2001