aminolevulinic acid has been researched along with Hypotension in 13 studies
Aminolevulinic Acid: A compound produced from succinyl-CoA and GLYCINE as an intermediate in heme synthesis. It is used as a PHOTOCHEMOTHERAPY for actinic KERATOSIS.
5-aminolevulinic acid : The simplest delta-amino acid in which the hydrogens at the gamma position are replaced by an oxo group. It is metabolised to protoporphyrin IX, a photoactive compound which accumulates in the skin. Used (in the form of the hydrochloride salt)in combination with blue light illumination for the treatment of minimally to moderately thick actinic keratosis of the face or scalp.
Hypotension: Abnormally low BLOOD PRESSURE that can result in inadequate blood flow to the brain and other vital organs. Common symptom is DIZZINESS but greater negative impacts on the body occur when there is prolonged depravation of oxygen and nutrients.
| Excerpt | Relevance | Reference |
|---|---|---|
| "These findings suggest that 5-ALA-HCl does not affect the antihypertensive agents-induced hypotensive effect, but enhances the bupivacaine-induced hypotensive effect, especially in SHRs, indicating that 5-ALA may contribute to anesthesia-induced hypotension via suppression of sympathetic nerve activity in patients with hypertension." | 8.31 | 5-Aminolevulinic acid hydrochloride enhances bupivacaine-induced hypotension in spontaneously hypertensive rats. ( Abe, M; Fukuda, N; Hara, T; Ishizuka, M; Ito, H; Katakawa, M; Otsuka, N, 2023) |
| "5-Aminolevulinic acid administration was associated with intraoperative hypotension in malignant glioma surgery, with increasing age and use of renin-angiotensin system inhibitors boosting the blood pressure-lowering effect of 5-aminolevulinic acid." | 8.12 | Association of 5-aminolevulinic acid with intraoperative hypotension in malignant glioma surgery. ( Fukuda, H; Fukuhara, H; Inoue, K; Ishida, T; Jobu, K; Kagimoto, N; Kawada, K; Kawanishi, Y; Masahira, N; Miyamura, M; Morisawa, S; Nakayama, T; Ogura, SI; Ohta, T; Takemura, M; Tamura, N; Ueba, T; Yamamoto, S, 2022) |
| "Use of 5-aminolevulinic acid for photodynamic malignant tumor diagnosis reportedly causes intraoperative hypotension (systolic blood pressure < 70 mmHg) during urologic surgery." | 8.12 | Association of 5-aminolevulinic acid with intraoperative hypotension in malignant glioma surgery. ( Fukuda, H; Fukuhara, H; Inoue, K; Ishida, T; Jobu, K; Kagimoto, N; Kawada, K; Kawanishi, Y; Masahira, N; Miyamura, M; Morisawa, S; Nakayama, T; Ogura, SI; Ohta, T; Takemura, M; Tamura, N; Ueba, T; Yamamoto, S, 2022) |
| "In this retrospective multicenter cohort study, we investigated intracellular nitric oxide as a candidate mediator of hypotension in response to 5-aminolevulinic acid in vitro in human umbilical vein endothelial cell cultures." | 8.12 | Association of 5-aminolevulinic acid with intraoperative hypotension in malignant glioma surgery. ( Fukuda, H; Fukuhara, H; Inoue, K; Ishida, T; Jobu, K; Kagimoto, N; Kawada, K; Kawanishi, Y; Masahira, N; Miyamura, M; Morisawa, S; Nakayama, T; Ogura, SI; Ohta, T; Takemura, M; Tamura, N; Ueba, T; Yamamoto, S, 2022) |
| "To investigate risk factors for orally administered 5-aminolevulinic acid (ALA)-induced hypotension for bladder cancer patients receiving photodynamic diagnosis (PDD)-assisted transurethral resection of bladder tumor (TURBT)." | 8.02 | Identification of risk factors associated with oral 5-aminolevulinic acid-induced hypotension in photodynamic diagnosis for non-muscle invasive bladder cancer: a multicenter retrospective study. ( Fukuhara, H; Hatakeyama, Y; Hyodo, Y; Inoue, K; Matsuyama, H; Mizokami, A; Nishimoto, K; Nohara, T; Okuhara, Y; Oyama, M, 2021) |
| "Transurethral resection of bladder tumor (TUR-BT) using 5-aminolevulinic acid (5-ALA) is common; however, intraoperative hypotension is frequent." | 8.02 | Oral 5-aminolevulinic acid administration prior to transurethral resection of bladder tumor causes intraoperative hypotension: Propensity score analysis. ( Ida, M; Kawaguchi, M; Naito, Y; Nakatani, S; Wang, X, 2021) |
| "A 72-year-old man with end-stage renal disease (ESRD) undergoing transurethral resection of a bladder tumor experienced severe and prolonged hypotension after receiving oral 5-aminolevulinic acid (5-ALA)." | 7.96 | Severe and Prolonged Hypotension After Oral 5-Aminolevulinic Acid Administration in a Patient With End-Stage Renal Disease Undergoing Transurethral Resection of a Bladder Tumor: A Case Report. ( Kida, T; Kobashi, T; Kobayashi, K; Sumitomo, M; Usuda, Y, 2020) |
| "Hypotension is an adverse effect of 5-ALA; however, its incidence and morbidity rates are unknown." | 5.91 | Incidence of perioperative hypotension in patients undergoing transurethral resection of bladder tumor after oral 5-aminolevulinic acid administration: a retrospective multicenter cohort study. ( Echigo, N; Goto, T; Inagawa, G; Kida, T; Kondo, Y; Nagamine, Y; Sumitomo, M; Yoshida, M; Yoshikawa, N, 2023) |
| "According to in vitro results, the low blood pressure induced by 5-aminolevulinic acid may be mediated by a nitric oxide increase in vascular endothelial cells." | 5.72 | Association of 5-aminolevulinic acid with intraoperative hypotension in malignant glioma surgery. ( Fukuda, H; Fukuhara, H; Inoue, K; Ishida, T; Jobu, K; Kagimoto, N; Kawada, K; Kawanishi, Y; Masahira, N; Miyamura, M; Morisawa, S; Nakayama, T; Ogura, SI; Ohta, T; Takemura, M; Tamura, N; Ueba, T; Yamamoto, S, 2022) |
| " The use of 5-aminolevulinic acid as the photosensitising agent has been associated with side effects, specifically hypotension." | 5.17 | Oral 5-aminolevulinic acid induced Photodynamic Diagnostic Ureterorenoscopy--does the blood pressure require monitoring? ( Aboumarzouk, OM; Bondad, J; Kata, SG; Moseley, H, 2013) |
| "These findings suggest that 5-ALA-HCl does not affect the antihypertensive agents-induced hypotensive effect, but enhances the bupivacaine-induced hypotensive effect, especially in SHRs, indicating that 5-ALA may contribute to anesthesia-induced hypotension via suppression of sympathetic nerve activity in patients with hypertension." | 4.31 | 5-Aminolevulinic acid hydrochloride enhances bupivacaine-induced hypotension in spontaneously hypertensive rats. ( Abe, M; Fukuda, N; Hara, T; Ishizuka, M; Ito, H; Katakawa, M; Otsuka, N, 2023) |
| "5-aminolevulinic acid hydrochloride is a highly effective drug in reducing tumor residuals in transurethral resection of the bladder tumors; however, hypotension is a serious side effect that causes clinical problems." | 4.31 | [Effectiveness of Pharmaceutical Intervention While Administering 5-Aminolevulinic Acid Hydrochloride through a Collaboration of Physicians and Pharmacists]. ( Aoyama, S; Kasahara, S; Komeda, H; Mizui, T; Tachi, T; Takai, A; Tanaka, K; Yasuda, M, 2023) |
| "5-Aminolevulinic acid administration was associated with intraoperative hypotension in malignant glioma surgery, with increasing age and use of renin-angiotensin system inhibitors boosting the blood pressure-lowering effect of 5-aminolevulinic acid." | 4.12 | Association of 5-aminolevulinic acid with intraoperative hypotension in malignant glioma surgery. ( Fukuda, H; Fukuhara, H; Inoue, K; Ishida, T; Jobu, K; Kagimoto, N; Kawada, K; Kawanishi, Y; Masahira, N; Miyamura, M; Morisawa, S; Nakayama, T; Ogura, SI; Ohta, T; Takemura, M; Tamura, N; Ueba, T; Yamamoto, S, 2022) |
| "Use of 5-aminolevulinic acid for photodynamic malignant tumor diagnosis reportedly causes intraoperative hypotension (systolic blood pressure < 70 mmHg) during urologic surgery." | 4.12 | Association of 5-aminolevulinic acid with intraoperative hypotension in malignant glioma surgery. ( Fukuda, H; Fukuhara, H; Inoue, K; Ishida, T; Jobu, K; Kagimoto, N; Kawada, K; Kawanishi, Y; Masahira, N; Miyamura, M; Morisawa, S; Nakayama, T; Ogura, SI; Ohta, T; Takemura, M; Tamura, N; Ueba, T; Yamamoto, S, 2022) |
| "In this retrospective multicenter cohort study, we investigated intracellular nitric oxide as a candidate mediator of hypotension in response to 5-aminolevulinic acid in vitro in human umbilical vein endothelial cell cultures." | 4.12 | Association of 5-aminolevulinic acid with intraoperative hypotension in malignant glioma surgery. ( Fukuda, H; Fukuhara, H; Inoue, K; Ishida, T; Jobu, K; Kagimoto, N; Kawada, K; Kawanishi, Y; Masahira, N; Miyamura, M; Morisawa, S; Nakayama, T; Ogura, SI; Ohta, T; Takemura, M; Tamura, N; Ueba, T; Yamamoto, S, 2022) |
| "To investigate risk factors for orally administered 5-aminolevulinic acid (ALA)-induced hypotension for bladder cancer patients receiving photodynamic diagnosis (PDD)-assisted transurethral resection of bladder tumor (TURBT)." | 4.02 | Identification of risk factors associated with oral 5-aminolevulinic acid-induced hypotension in photodynamic diagnosis for non-muscle invasive bladder cancer: a multicenter retrospective study. ( Fukuhara, H; Hatakeyama, Y; Hyodo, Y; Inoue, K; Matsuyama, H; Mizokami, A; Nishimoto, K; Nohara, T; Okuhara, Y; Oyama, M, 2021) |
| "Transurethral resection of bladder tumor (TUR-BT) using 5-aminolevulinic acid (5-ALA) is common; however, intraoperative hypotension is frequent." | 4.02 | Oral 5-aminolevulinic acid administration prior to transurethral resection of bladder tumor causes intraoperative hypotension: Propensity score analysis. ( Ida, M; Kawaguchi, M; Naito, Y; Nakatani, S; Wang, X, 2021) |
| "A 72-year-old man with end-stage renal disease (ESRD) undergoing transurethral resection of a bladder tumor experienced severe and prolonged hypotension after receiving oral 5-aminolevulinic acid (5-ALA)." | 3.96 | Severe and Prolonged Hypotension After Oral 5-Aminolevulinic Acid Administration in a Patient With End-Stage Renal Disease Undergoing Transurethral Resection of a Bladder Tumor: A Case Report. ( Kida, T; Kobashi, T; Kobayashi, K; Sumitomo, M; Usuda, Y, 2020) |
| "Hypotension is a common occurrence after the ingestion of 5-ALA." | 2.78 | Oral 5-aminolevulinic acid induced Photodynamic Diagnostic Ureterorenoscopy--does the blood pressure require monitoring? ( Aboumarzouk, OM; Bondad, J; Kata, SG; Moseley, H, 2013) |
| "Hypotension was defined as <80% of the systolic or diastolic baseline blood pressure." | 2.78 | Oral 5-aminolevulinic acid induced Photodynamic Diagnostic Ureterorenoscopy--does the blood pressure require monitoring? ( Aboumarzouk, OM; Bondad, J; Kata, SG; Moseley, H, 2013) |
| " Hypotension and alteration of liver functions have been reported as potential adverse effects." | 2.78 | Risk factors for developing oral 5-aminolevulinic acid-induced side effects in patients undergoing fluorescence guided resection. ( Chung, IW; Eljamel, S, 2013) |
| "Hypotension is an adverse effect of 5-ALA; however, its incidence and morbidity rates are unknown." | 1.91 | Incidence of perioperative hypotension in patients undergoing transurethral resection of bladder tumor after oral 5-aminolevulinic acid administration: a retrospective multicenter cohort study. ( Echigo, N; Goto, T; Inagawa, G; Kida, T; Kondo, Y; Nagamine, Y; Sumitomo, M; Yoshida, M; Yoshikawa, N, 2023) |
| "5-aminolevulinic acid hydrochloride is a highly effective drug in reducing tumor residuals in transurethral resection of the bladder tumors; however, hypotension is a serious side effect that causes clinical problems." | 1.91 | [Effectiveness of Pharmaceutical Intervention While Administering 5-Aminolevulinic Acid Hydrochloride through a Collaboration of Physicians and Pharmacists]. ( Aoyama, S; Kasahara, S; Komeda, H; Mizui, T; Tachi, T; Takai, A; Tanaka, K; Yasuda, M, 2023) |
| "According to in vitro results, the low blood pressure induced by 5-aminolevulinic acid may be mediated by a nitric oxide increase in vascular endothelial cells." | 1.72 | Association of 5-aminolevulinic acid with intraoperative hypotension in malignant glioma surgery. ( Fukuda, H; Fukuhara, H; Inoue, K; Ishida, T; Jobu, K; Kagimoto, N; Kawada, K; Kawanishi, Y; Masahira, N; Miyamura, M; Morisawa, S; Nakayama, T; Ogura, SI; Ohta, T; Takemura, M; Tamura, N; Ueba, T; Yamamoto, S, 2022) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 6 (46.15) | 24.3611 |
| 2020's | 7 (53.85) | 2.80 |
| Authors | Studies |
|---|---|
| Fukuhara, H | 3 |
| Nohara, T | 2 |
| Nishimoto, K | 1 |
| Hatakeyama, Y | 1 |
| Hyodo, Y | 1 |
| Okuhara, Y | 1 |
| Oyama, M | 1 |
| Mizokami, A | 2 |
| Inoue, K | 2 |
| Matsuyama, H | 1 |
| Morisawa, S | 1 |
| Jobu, K | 1 |
| Ishida, T | 1 |
| Kawada, K | 1 |
| Fukuda, H | 1 |
| Kawanishi, Y | 1 |
| Nakayama, T | 1 |
| Yamamoto, S | 1 |
| Tamura, N | 1 |
| Takemura, M | 1 |
| Kagimoto, N | 1 |
| Ohta, T | 1 |
| Masahira, N | 1 |
| Ogura, SI | 1 |
| Ueba, T | 1 |
| Miyamura, M | 1 |
| Fukuda, N | 1 |
| Katakawa, M | 1 |
| Ito, H | 1 |
| Hara, T | 1 |
| Otsuka, N | 1 |
| Ishizuka, M | 1 |
| Abe, M | 1 |
| Kondo, Y | 1 |
| Nagamine, Y | 1 |
| Yoshikawa, N | 1 |
| Echigo, N | 1 |
| Kida, T | 2 |
| Sumitomo, M | 2 |
| Yoshida, M | 1 |
| Inagawa, G | 1 |
| Goto, T | 1 |
| Tanaka, K | 1 |
| Tachi, T | 1 |
| Takai, A | 1 |
| Aoyama, S | 1 |
| Yasuda, M | 1 |
| Kasahara, S | 1 |
| Komeda, H | 1 |
| Mizui, T | 1 |
| Kato, Y | 1 |
| Nakano, T | 1 |
| Nakagawa, T | 1 |
| Iwamoto, H | 1 |
| Yaegashi, H | 1 |
| Nakashima, K | 1 |
| Iijima, M | 1 |
| Kawaguchi, S | 1 |
| Shigehara, K | 1 |
| Izumi, K | 1 |
| Kadono, Y | 1 |
| Matsumoto, H | 1 |
| Kobashi, T | 1 |
| Usuda, Y | 1 |
| Kobayashi, K | 1 |
| Nakatani, S | 1 |
| Ida, M | 1 |
| Wang, X | 1 |
| Naito, Y | 1 |
| Kawaguchi, M | 1 |
| Bondad, J | 1 |
| Aboumarzouk, OM | 1 |
| Moseley, H | 1 |
| Kata, SG | 1 |
| Chung, IW | 1 |
| Eljamel, S | 1 |
| Eichhorn, V | 1 |
| Maerz, A | 1 |
| Salomon, G | 1 |
| Blanc, IF | 1 |
| Reuter, DA | 1 |
| Goetz, AE | 1 |
3 trials available for aminolevulinic acid and Hypotension
| Article | Year |
|---|---|
Oral 5-aminolevulinic acid induced Photodynamic Diagnostic Ureterorenoscopy--does the blood pressure require monitoring?
Topics: Administration, Oral; Aged; Aminolevulinic Acid; Blood Pressure; Contrast Media; Female; Humans; Hyp | 2013 |
Risk factors for developing oral 5-aminolevulinic acid-induced side effects in patients undergoing fluorescence guided resection.
Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Aminolevulinic Acid; Chemical and Drug Induced | 2013 |
Hemodynamic effects of orally administered delta-ALA during radical prostatectomy.
Topics: Administration, Oral; Aged; Aminolevulinic Acid; Arterial Pressure; Case-Control Studies; Cohort Stu | 2013 |
10 other studies available for aminolevulinic acid and Hypotension
| Article | Year |
|---|---|
Identification of risk factors associated with oral 5-aminolevulinic acid-induced hypotension in photodynamic diagnosis for non-muscle invasive bladder cancer: a multicenter retrospective study.
Topics: Aged; Aged, 80 and over; Aminolevulinic Acid; Anesthesia, General; Anesthesia, Spinal; Calcium Chann | 2021 |
Association of 5-aminolevulinic acid with intraoperative hypotension in malignant glioma surgery.
Topics: Aminolevulinic Acid; Cohort Studies; Endothelial Cells; Glioma; Humans; Hypotension; Photochemothera | 2022 |
5-Aminolevulinic acid hydrochloride enhances bupivacaine-induced hypotension in spontaneously hypertensive rats.
Topics: Aminolevulinic Acid; Amlodipine; Animals; Antihypertensive Agents; Blood Pressure; Bupivacaine; Hype | 2023 |
Incidence of perioperative hypotension in patients undergoing transurethral resection of bladder tumor after oral 5-aminolevulinic acid administration: a retrospective multicenter cohort study.
Topics: Adult; Aged; Aminolevulinic Acid; Cohort Studies; Humans; Hypotension; Incidence; Kidney Diseases; R | 2023 |
[Effectiveness of Pharmaceutical Intervention While Administering 5-Aminolevulinic Acid Hydrochloride through a Collaboration of Physicians and Pharmacists].
Topics: Aminolevulinic Acid; Antihypertensive Agents; Humans; Hypertension; Hypotension; Pharmaceutical Prep | 2023 |
Intraoperative hypotension caused by oral administration of 5-aminolevulinic acid for photodynamic diagnosis in patients with bladder cancer.
Topics: Administration, Oral; Aged; Aged, 80 and over; Aminolevulinic Acid; Female; Humans; Hypotension; Int | 2019 |
Editorial Comment from Dr Matsumoto to Intraoperative hypotension caused by oral administration of 5-aminolevulinic acid for photodynamic diagnosis in patients with bladder cancer.
Topics: Administration, Oral; Aminolevulinic Acid; Humans; Hypotension; Photosensitizing Agents; Urinary Bla | 2019 |
Editorial Comment from Dr Fukuhara to Intraoperative hypotension caused by oral administration of 5-aminolevulinic acid for photodynamic diagnosis in patients with bladder cancer.
Topics: Administration, Oral; Aminolevulinic Acid; Humans; Hypotension; Photosensitizing Agents; Urinary Bla | 2019 |
Severe and Prolonged Hypotension After Oral 5-Aminolevulinic Acid Administration in a Patient With End-Stage Renal Disease Undergoing Transurethral Resection of a Bladder Tumor: A Case Report.
Topics: Administration, Oral; Aged; Aminolevulinic Acid; Humans; Hypotension; Kidney Failure, Chronic; Norep | 2020 |
Oral 5-aminolevulinic acid administration prior to transurethral resection of bladder tumor causes intraoperative hypotension: Propensity score analysis.
Topics: Aminolevulinic Acid; Humans; Hypotension; Photochemotherapy; Photosensitizing Agents; Propensity Sco | 2021 |