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aminolevulinic acid and Hidradenitis Suppurativa

aminolevulinic acid has been researched along with Hidradenitis Suppurativa in 20 studies

Aminolevulinic Acid: A compound produced from succinyl-CoA and GLYCINE as an intermediate in heme synthesis. It is used as a PHOTOCHEMOTHERAPY for actinic KERATOSIS.
5-aminolevulinic acid : The simplest delta-amino acid in which the hydrogens at the gamma position are replaced by an oxo group. It is metabolised to protoporphyrin IX, a photoactive compound which accumulates in the skin. Used (in the form of the hydrochloride salt)in combination with blue light illumination for the treatment of minimally to moderately thick actinic keratosis of the face or scalp.

Hidradenitis Suppurativa: A chronic suppurative and cicatricial disease of the apocrine glands occurring chiefly in the axillae in women and in the groin and anal regions in men. It is characterized by poral occlusion with secondary bacterial infection, evolving into abscesses which eventually rupture. As the disease becomes chronic, ulcers appear, sinus tracts enlarge, fistulas develop, and fibrosis and scarring become evident.

Research Excerpts

ExcerptRelevanceReference
"Hidradenitis suppurativa is a chronic inflammatory skin disease which has an estimated prevalence of 1%."6.53Photodynamic therapy with intralesional methylene blue and a 635 nm light-emitting diode lamp in hidradenitis suppurativa: a retrospective follow-up study in 7 patients and a review of the literature. ( Agut-Busquet, E; García-Malinis, A; Gilaberte, Y; Luelmo, J; Ribera-Pibernat, M; Romaní, J, 2016)
"To perform a systematic review of available literature regarding the use of 5-aminolevulinic acid (ALA) and ALA derivative photodynamic therapy (PDT) in the treatment of hidradenitis suppurativa (HS) and provide recommendations on its use."5.41Systematic review of photodynamic therapy for the treatment of hidradenitis suppurativa. ( Bakker, C; Farah, RS; Freeman, T; Goldfarb, N; Hamzavi, IH; Narla, S; Reshetylo, S, 2023)
"Hidradenitis suppurativa is a chronic, recurring, and disabling inflammatory condition of the skin."2.58Treating hidradenitis suppurativa with photodynamic therapy. ( Mordon, S, 2018)
"Hidradenitis suppurativa is a chronic inflammatory skin disease which has an estimated prevalence of 1%."2.53Photodynamic therapy with intralesional methylene blue and a 635 nm light-emitting diode lamp in hidradenitis suppurativa: a retrospective follow-up study in 7 patients and a review of the literature. ( Agut-Busquet, E; García-Malinis, A; Gilaberte, Y; Luelmo, J; Ribera-Pibernat, M; Romaní, J, 2016)
"Acne inversa is likely to result from aberrant cellular immunity and dysfunction of the hair follicle in which coagulase negative staphylococcus (CONS) and perhaps other bacteria appear e."2.52The use of photodynamic therapy to treat hidradenitis suppurativa a review and critical analysis. ( Scheinfeld, N, 2015)
"The successful treatment of hidradenitis suppurativa (HS) with intralesional photodynamic therapy (IL-PDT) has been previously reported in some case series published a few years ago."1.62Intralesional photodynamic therapy in hidradenitis suppurativa: Getting closer to the target. ( Corral-Magaña, O; Del Pozo, LJ; Garcias-Ladaria, J; Martín-Santiago, A, 2021)
"Hidradenitis suppurativa/acne inversa (HS/AI) is a type of chronic suppurative inflammatory reaction of the hair follicles characterized by recurrent dermal abscesses, sinus tracts and scars."1.48Photodynamic therapy for Hidradenitis Suppurativa/acne inversa: Case report. ( Yang, Y; Zhang, Y; Zou, X, 2018)
"The relapses and the chronicity of acne inversa cause a significant impact on the quality of life of the affected patients and urge for a search of more effective treatments."1.35Pulsed dye laser-mediated photodynamic therapy for acne inversa is not successful: a pilot study on four cases. ( Khemis, A; Ortonne, JP; Passeron, T, 2009)

Research

Studies (20)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's6 (30.00)29.6817
2010's9 (45.00)24.3611
2020's5 (25.00)2.80

Authors

AuthorsStudies
Yan, J1
Zhang, G1
Liao, C1
Wang, X1
Shi, L1
Reshetylo, S1
Narla, S1
Bakker, C1
Freeman, T1
Farah, RS1
Hamzavi, IH1
Goldfarb, N1
Fu, Z1
Wu, Q1
Bu, W1
Xiao, D1
Zhou, ZW1
Chen, XD1
Wu, XY1
Li, Y1
Li, T1
Chen, L1
Zhang, L1
Garcias-Ladaria, J1
Corral-Magaña, O1
Del Pozo, LJ1
Martín-Santiago, A1
Valladares-Narganes, LM1
Rodríguez-Prieto, MA1
Blanco-Suárez, MD1
Rodriguez-Lage, C1
García-Doval, I1
Scheinfeld, N1
Agut-Busquet, E1
Romaní, J1
Gilaberte, Y1
García-Malinis, A1
Ribera-Pibernat, M1
Luelmo, J1
Suárez Valladares, MJ1
Eiris Salvado, N1
Rodríguez Prieto, MA1
Passeron, T1
Khemis, A1
Ortonne, JP1
Saraceno, R1
Teoli, M1
Casciello, C1
Chimenti, S1
Sotiriou, E1
Apalla, Z1
Maliamani, F1
Ioannides, D1
Guglielmetti, A1
Bedoya, J1
Acuna, M1
Leiva, V1
Gonzalez, S1
Schweiger, ES1
Riddle, CC1
Aires, DJ1
Strauss, RM1
Pollock, B1
Stables, GI1
Goulden, V1
Cunliffe, WJ1
Rivard, J1
Ozog, D1
Gold, MH1
Mordon, S1
Zhang, Y1
Yang, Y1
Zou, X1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Intralesional Diode Laser Treatment of Fistulas in Hidradenitis Suppurativa: Protocol for a Within-person Randomised Trial[NCT04508374]20 participants (Anticipated)Interventional2020-12-10Recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

5 reviews available for aminolevulinic acid and Hidradenitis Suppurativa

ArticleYear
Systematic review of photodynamic therapy for the treatment of hidradenitis suppurativa.
    Photodermatology, photoimmunology & photomedicine, 2023, Volume: 39, Issue:1

    Topics: Aminolevulinic Acid; Hidradenitis Suppurativa; Humans; Light; Photochemotherapy; Photosensitizing Ag

2023
The use of photodynamic therapy to treat hidradenitis suppurativa a review and critical analysis.
    Dermatology online journal, 2015, Jan-15, Volume: 21, Issue:1

    Topics: Aminolevulinic Acid; Biofilms; Hidradenitis Suppurativa; Humans; Photochemotherapy; Photosensitizing

2015
Photodynamic therapy with intralesional methylene blue and a 635 nm light-emitting diode lamp in hidradenitis suppurativa: a retrospective follow-up study in 7 patients and a review of the literature.
    Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology, 2016, 08-04, Volume: 15, Issue:8

    Topics: Adult; Aminolevulinic Acid; Anti-Bacterial Agents; Female; Follow-Up Studies; Hidradenitis Suppurati

2016
Aminolevulinic acid photodynamic therapy for hidradenitis suppurativa.
    Dermatologic clinics, 2007, Volume: 25, Issue:1

    Topics: Aminolevulinic Acid; Hidradenitis Suppurativa; Humans; Photochemotherapy; Photosensitizing Agents

2007
Treating hidradenitis suppurativa with photodynamic therapy.
    Journal of cosmetic and laser therapy : official publication of the European Society for Laser Dermatology, 2018, Volume: 20, Issue:4

    Topics: Administration, Cutaneous; Aminolevulinic Acid; Hidradenitis Suppurativa; Humans; Injections, Intral

2018

Trials

1 trial available for aminolevulinic acid and Hidradenitis Suppurativa

ArticleYear
Treatment of hidradenitis suppurativa by photodynamic therapy with aminolevulinic acid: preliminary results.
    Journal of drugs in dermatology : JDD, 2011, Volume: 10, Issue:4

    Topics: Administration, Topical; Adult; Aminolevulinic Acid; Female; Hidradenitis Suppurativa; Humans; Male;

2011

Other Studies

14 other studies available for aminolevulinic acid and Hidradenitis Suppurativa

ArticleYear
ALA-iPDT for follicular occlusion tetrad concomitant with pachyonychia congenital type Ⅱ and ankylosing spondylitis.
    Photodiagnosis and photodynamic therapy, 2022, Volume: 39

    Topics: Aminolevulinic Acid; Hidradenitis Suppurativa; Humans; Male; Nails, Malformed; Photochemotherapy; Sp

2022
Treatment of severe hidradenitis suppurativa with a combination of 5-aminolevulinic acid photodynamic therapy, surgery, and secukinumab.
    Photodiagnosis and photodynamic therapy, 2023, Volume: 42

    Topics: Aminolevulinic Acid; Hidradenitis Suppurativa; Humans; Photochemotherapy; Photosensitizing Agents

2023
5-ALA PDT successfully treats facial hidradenitis suppurativa-induced severe hypertrophic scar.
    Photodiagnosis and photodynamic therapy, 2019, Volume: 28

    Topics: Adult; Aminolevulinic Acid; Cicatrix, Hypertrophic; Hidradenitis Suppurativa; Humans; Male; Photoche

2019
Patient satisfaction and quality of life after surgery combined with 5-aminolevulinic acid-based photodynamic therapy for hidradenitis suppurativa.
    Journal of the American Academy of Dermatology, 2021, Volume: 85, Issue:4

    Topics: Aminolevulinic Acid; Hidradenitis Suppurativa; Humans; Patient Satisfaction; Photochemotherapy; Qual

2021
Intralesional photodynamic therapy in hidradenitis suppurativa: Getting closer to the target.
    Photodiagnosis and photodynamic therapy, 2021, Volume: 34

    Topics: Aminolevulinic Acid; Hidradenitis Suppurativa; Humans; Photochemotherapy; Photosensitizing Agents; R

2021
Treatment of hidradenitis suppurativa with intralesional photodynamic therapy using a laser diode attached to an optical cable: a promising new approach.
    The British journal of dermatology, 2015, Volume: 172, Issue:4

    Topics: Adult; Aminolevulinic Acid; Female; Hidradenitis Suppurativa; Humans; Injections, Intralesional; Las

2015
Treatment of hidradenitis suppurativa with intralesional photodynamic therapy with 5-aminolevulinic acid and 630nm laser beam.
    Journal of dermatological science, 2017, Volume: 85, Issue:3

    Topics: Adult; Aminolevulinic Acid; Female; Hidradenitis Suppurativa; Humans; Injections, Intralesional; Las

2017
Pulsed dye laser-mediated photodynamic therapy for acne inversa is not successful: a pilot study on four cases.
    The Journal of dermatological treatment, 2009, Volume: 20, Issue:5

    Topics: Aminolevulinic Acid; Hidradenitis Suppurativa; Humans; Lasers, Dye; Photochemotherapy; Photosensitiz

2009
Methyl aminolaevulinate photodynamic therapy for the treatment of hidradenitis suppurativa and pilonidal cysts.
    Photodermatology, photoimmunology & photomedicine, 2009, Volume: 25, Issue:3

    Topics: Adult; Aminolevulinic Acid; Hidradenitis Suppurativa; Humans; Male; Photochemotherapy; Pilonidal Sin

2009
Treatment of recalcitrant hidradenitis suppurativa with photodynamic therapy: report of five cases.
    Clinical and experimental dermatology, 2009, Volume: 34, Issue:7

    Topics: Adult; Aminolevulinic Acid; Chronic Disease; Female; Hidradenitis Suppurativa; Humans; Male; Photoch

2009
Successful aminolevulinic acid photodynamic therapy for recalcitrant severe hidradenitis suppurativa.
    Photodermatology, photoimmunology & photomedicine, 2010, Volume: 26, Issue:2

    Topics: Adult; Aminolevulinic Acid; Female; Hidradenitis Suppurativa; Humans; Photochemotherapy; Photosensit

2010
Photodynamic therapy using aminolaevulinic acid does not lead to clinical improvement in hidradenitis suppurativa.
    The British journal of dermatology, 2005, Volume: 152, Issue:4

    Topics: Administration, Topical; Aminolevulinic Acid; Hidradenitis Suppurativa; Humans; Photochemotherapy; P

2005
Henry Ford Hospital dermatology experience with Levulan Kerastick and blue light photodynamic therapy.
    Journal of drugs in dermatology : JDD, 2006, Volume: 5, Issue:6

    Topics: Acne Vulgaris; Adult; Aminolevulinic Acid; Female; Hidradenitis Suppurativa; Humans; Keratosis; Male

2006
Photodynamic therapy for Hidradenitis Suppurativa/acne inversa: Case report.
    Photodiagnosis and photodynamic therapy, 2018, Volume: 22

    Topics: Adult; Aminolevulinic Acid; Hidradenitis Suppurativa; Humans; Levulinic Acids; Male; Photochemothera

2018