aminolevulinic acid has been researched along with Glial Cell Tumors in 278 studies
Aminolevulinic Acid: A compound produced from succinyl-CoA and GLYCINE as an intermediate in heme synthesis. It is used as a PHOTOCHEMOTHERAPY for actinic KERATOSIS.
5-aminolevulinic acid : The simplest delta-amino acid in which the hydrogens at the gamma position are replaced by an oxo group. It is metabolised to protoporphyrin IX, a photoactive compound which accumulates in the skin. Used (in the form of the hydrochloride salt)in combination with blue light illumination for the treatment of minimally to moderately thick actinic keratosis of the face or scalp.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Five-aminolevulinic acid (5-ALA) is used for fluorescence-guided resections of malignant glioma at a dose of 20 mg/kg; yet, it is unknown whether lower doses may also provide efficacy." | 9.24 | Randomized, Prospective Double-Blinded Study Comparing 3 Different Doses of 5-Aminolevulinic Acid for Fluorescence-Guided Resections of Malignant Gliomas. ( Pichlmeier, U; Stepp, H; Stummer, W; Wiestler, OD, 2017) |
| "The utility of oral 5-aminolevulinic acid (5-ALA)/protoporphyrin fluorescence for the resection of high-grade gliomas is well documented." | 9.24 | A Phase 1 Dose-Escalation Study of Oral 5-Aminolevulinic Acid in Adult Patients Undergoing Resection of a Newly Diagnosed or Recurrent High-Grade Glioma. ( Amin, DV; Cozzens, JW; Espinosa, JA; Jones, BA; Lokaitis, BC; MacGregor, M; Michael, AP; Moore, BE, 2017) |
| "OBJECT There is evidence that 5-aminolevulinic acid (ALA) facilitates greater extent of resection and improves 6-month progression-free survival in patients with high-grade gliomas." | 9.22 | A prospective Phase II clinical trial of 5-aminolevulinic acid to assess the correlation of intraoperative fluorescence intensity and degree of histologic cellularity during resection of high-grade gliomas. ( Berger, MS; Chang, S; Hervey-Jumper, SL; Lau, D; McDermott, MW; Molinaro, AM; Phillips, JJ, 2016) |
| "5-Aminolevulinic acid (5-ALA) fluorescence is a validated technique for resection of high grade gliomas (HGG); the aim of this study was to evaluate the surgical outcome and the intraoperative findings in a consecutive series of patients." | 9.19 | 5-Aminolevulinic acid fluorescence in high grade glioma surgery: surgical outcome, intraoperative findings, and fluorescence patterns. ( Cecchin, D; Ciccarino, P; Della Puppa, A; Lombardi, G; Rolma, G; Rossetto, M, 2014) |
| "5-Aminolevulinic acid is a non-fluorescent prodrug that leads to intracellular accumulation of fluorescent porphyrins in malignant gliomas-a finding that is under investigation for intraoperative identification and resection of these tumours." | 9.12 | Fluorescence-guided surgery with 5-aminolevulinic acid for resection of malignant glioma: a randomised controlled multicentre phase III trial. ( Meinel, T; Pichlmeier, U; Reulen, HJ; Stummer, W; Wiestler, OD; Zanella, F, 2006) |
| "322 patients aged 23-73 years with suspected malignant glioma amenable to complete resection of contrast-enhancing tumour were randomly assigned to 20 mg/kg bodyweight 5-aminolevulinic acid for fluorescence-guided resection (n=161) or to conventional microsurgery with white light (n=161)." | 9.12 | Fluorescence-guided surgery with 5-aminolevulinic acid for resection of malignant glioma: a randomised controlled multicentre phase III trial. ( Meinel, T; Pichlmeier, U; Reulen, HJ; Stummer, W; Wiestler, OD; Zanella, F, 2006) |
| "Tumour fluorescence derived from 5-aminolevulinic acid enables more complete resections of contrast-enhancing tumour, leading to improved progression-free survival in patients with malignant glioma." | 9.12 | Fluorescence-guided surgery with 5-aminolevulinic acid for resection of malignant glioma: a randomised controlled multicentre phase III trial. ( Meinel, T; Pichlmeier, U; Reulen, HJ; Stummer, W; Wiestler, OD; Zanella, F, 2006) |
| "For optimizing high-grade glioma resection, 5-aminolevulinic acid is a reliable tool." | 9.05 | The Use of 5-Aminolevulinic Acid in Low-Grade Glioma Resection: A Systematic Review. ( Abi-Aad, KR; Abunimer, AM; Almekkawi, AK; Aoun, SG; Bendok, BR; El Ahmadieh, TY; El Tecle, NE; Patel, T; Plitt, AR; Stummer, W; Wu, EM, 2020) |
| "To study the role of 5-aminolevulinic acid in low-grade glioma resection and assess positive fluorescence rates and the effect on the extent of resection." | 9.05 | The Use of 5-Aminolevulinic Acid in Low-Grade Glioma Resection: A Systematic Review. ( Abi-Aad, KR; Abunimer, AM; Almekkawi, AK; Aoun, SG; Bendok, BR; El Ahmadieh, TY; El Tecle, NE; Patel, T; Plitt, AR; Stummer, W; Wu, EM, 2020) |
| " Studies that correlated 5-aminolevulinic acid fluorescence with low-grade glioma in the setting of operative resection were selected." | 9.05 | The Use of 5-Aminolevulinic Acid in Low-Grade Glioma Resection: A Systematic Review. ( Abi-Aad, KR; Abunimer, AM; Almekkawi, AK; Aoun, SG; Bendok, BR; El Ahmadieh, TY; El Tecle, NE; Patel, T; Plitt, AR; Stummer, W; Wu, EM, 2020) |
| "There is an overall low correlation between 5-aminolevulinic acid fluorescence and low-grade glioma." | 9.05 | The Use of 5-Aminolevulinic Acid in Low-Grade Glioma Resection: A Systematic Review. ( Abi-Aad, KR; Abunimer, AM; Almekkawi, AK; Aoun, SG; Bendok, BR; El Ahmadieh, TY; El Tecle, NE; Patel, T; Plitt, AR; Stummer, W; Wu, EM, 2020) |
| "5-Aminolevulinic acid (ALA) has been widely used as an intravital fluorescence marker in the fluorescence-guided resection of malignant gliomas." | 9.05 | 5-Aminolevulinic Acid: Pitfalls of Fluorescence-guided Resection for Malignant Gliomas and Application for Malignant Glioma Therapy. ( Kitagawa, T; Miyaoka, R; Nakano, Y; Saito, T; Suzuki, K; Takamatsu, S; Yamamoto, J, 2020) |
| " Search terms include "glioma" and "aminolevulinic acid"." | 9.05 | 5-Aminolevulinic acid for recurrent malignant gliomas: A systematic review. ( Broekx, S; De Vleeschouwer, S; Weyns, F, 2020) |
| "Fluorescence guided surgery (FGS) with five-aminolevulinic acid (5-ALA) is expected to revolutionize neurosurgical care of patients with high-grade gliomas (HGG)." | 9.01 | 5-Aminolevulinic acid fluorescence guided surgery for recurrent high-grade gliomas. ( Berger, MS; Chohan, MO, 2019) |
| "This review describes the existing literature discussing the utilization of 5-aminolevulinic acid for fluorescence guided surgery in low-grade gliomas, including its pertinence in identification of anaplastic foci and potential role in guiding resection following combination with augmentation strategies for detection." | 9.01 | Fluorescence-guided surgery with aminolevulinic acid for low-grade gliomas. ( Hendricks, BK; Sanai, N; Stummer, W, 2019) |
| "The advance in operative technology and growth of research analyzing 5-aminolevulinic acid will continue to enhance the role of fluorescence guided surgery within the standard of surgical management for low-grade gliomas." | 9.01 | Fluorescence-guided surgery with aminolevulinic acid for low-grade gliomas. ( Hendricks, BK; Sanai, N; Stummer, W, 2019) |
| " 5-aminolevulinic acid (5-ALA), an intermediate in the heme synthesis pathway, is a photosensitizing precursor with FDA approval for PDT of actinic keratosis and as an intraoperative imaging agent for fluorescence-guided visualization of malignant tissue during glioma surgery." | 9.01 | 5-aminolevulinic acid photodynamic therapy for the treatment of high-grade gliomas. ( Bouras, A; Bozec, D; Busch, TM; Cramer, G; Garvey, KL; Hadjipanayis, CG; Jesu Raj, JG; Mahmoudi, K; Stepp, H, 2019) |
| "5-Aminolevulinic acid (5-ALA) has been approved as an intraoperative adjunct in glioma surgery in Europe, but not North America." | 8.93 | The role of 5-aminolevulinic acid in enhancing surgery for high-grade glioma, its current boundaries, and future perspectives: A systematic review. ( Bernstein, M; Hachem, LD; Klironomos, G; Mansouri, A; Mansouri, S; Vogelbaum, MA; Zadeh, G, 2016) |
| " 5-Aminolevulinic acid (ALA) induced protoporphyrin IX (PpIX) has proven its rational in fluoro-guided resection of malignant gliomas due to a selective tumor uptake and minimal skin sensitization." | 8.90 | Experimental use of photodynamic therapy in high grade gliomas: a review focused on 5-aminolevulinic acid. ( Lejeune, JP; Mordon, S; Reyns, N; Tetard, MC; Vermandel, M, 2014) |
| "5-aminolevulinic acid (ALA) is a precursor of haemoglobin which leads to the synthesis of porphyrins in malignant gliomas which then appears with red fluorescence under blue light." | 8.89 | [Fluorescence-guided surgery with 5-aminolevulinic acid for resection of malignant gliomas--a new treatment modality]. ( Cortnum, S; Laursen, R, 2013) |
| "We performed a systematic review and meta-analysis to address the (added) value of intraoperative 5-aminolevulinic acid (5-ALA)-guided resection of high-grade malignant gliomas compared with conventional neuronavigation-guided resection, with respect to diagnostic accuracy, extent of tumor resection, safety, and survival." | 8.89 | Intraoperative fluorescence-guided resection of high-grade malignant gliomas using 5-aminolevulinic acid-induced porphyrins: a systematic review and meta-analysis of prospective studies. ( Chen, X; Dong, X; Han, D; Li, H; Liu, H; Liu, Y; Shen, C; Shi, C; Teng, L; Wang, C; Wang, L; Wu, J; Yang, G; Zhao, S, 2013) |
| " This study investigated the efficacy of 5-aminolevulinic acid-mediated photodynamic therapy (ALA-PDT) in destructing glioma stem cells (GSCs), including the mesenchymal subtype (MES-GSCs) demonstrated to have the lowest radio- and chemosensitivity." | 8.31 | Ablation efficacy of 5-aminolevulinic acid-mediated photodynamic therapy on human glioma stem cells. ( Fujishiro, T; Fukunaga, K; Furuse, M; Hiramatsu, R; Hosomi, R; Ikeda, N; Kajimoto, Y; Kawabata, S; Kuroiwa, T; Nakano, I; Nonoguchi, N; Omura, N; Park, Y; Wanibuchi, M; Yagi, R, 2023) |
| "The exoscope has been proposed as a valid tool in 5-aminolevulinic acid-guided resection of high-grade gliomas." | 8.31 | A Comparative Analysis with Exoscope and Optical Microscope for Intraoperative Visualization and Surgical Workflow in 5-Aminolevulinic Acid-Guided Resection of High-Grade Gliomas. ( Agostini, L; Della Pepa, GM; Doglietto, F; Mattogno, P; Menna, G; Olivi, A, 2023) |
| "Complete resection of glioblastoma via a supraorbital transciliary approach with 5-Aminolevulinic Acid use was performed without any complications, as demonstrated on postoperative MRI." | 8.31 | Supraorbital transciliary approach as primary route to fronto-basal high grade glioma resection with 5-Aminolevulinic Acid use: Technical note. ( Aboukaïs, R; Bourgeois, P; Devalckeneer, A; Lejeune, JP; Reyns, N, 2023) |
| "Boron neutron capture therapy (BNCT) is a high-LET particle radiotherapy clinically tested for treating malignant gliomas." | 8.31 | 5-Aminolevulinic acid increases boronophenylalanine uptake into glioma stem cells and may sensitize malignant glioma to boron neutron capture therapy. ( Fukumura, M; Futamura, G; Hiramatsu, R; Ikeda, N; Kanemitsu, T; Kawabata, S; Kuroiwa, T; Nakano, I; Nonoguchi, N; Sampetrean, O; Saya, H; Suzuki, M; Takata, T; Takeuchi, K; Tanaka, H; Wanibuchi, M, 2023) |
| "5-Aminolevulinic acid administration was associated with intraoperative hypotension in malignant glioma surgery, with increasing age and use of renin-angiotensin system inhibitors boosting the blood pressure-lowering effect of 5-aminolevulinic acid." | 8.12 | Association of 5-aminolevulinic acid with intraoperative hypotension in malignant glioma surgery. ( Fukuda, H; Fukuhara, H; Inoue, K; Ishida, T; Jobu, K; Kagimoto, N; Kawada, K; Kawanishi, Y; Masahira, N; Miyamura, M; Morisawa, S; Nakayama, T; Ogura, SI; Ohta, T; Takemura, M; Tamura, N; Ueba, T; Yamamoto, S, 2022) |
| "Use of 5-aminolevulinic acid for photodynamic malignant tumor diagnosis reportedly causes intraoperative hypotension (systolic blood pressure < 70 mmHg) during urologic surgery." | 8.12 | Association of 5-aminolevulinic acid with intraoperative hypotension in malignant glioma surgery. ( Fukuda, H; Fukuhara, H; Inoue, K; Ishida, T; Jobu, K; Kagimoto, N; Kawada, K; Kawanishi, Y; Masahira, N; Miyamura, M; Morisawa, S; Nakayama, T; Ogura, SI; Ohta, T; Takemura, M; Tamura, N; Ueba, T; Yamamoto, S, 2022) |
| "In this retrospective multicenter cohort study, we investigated intracellular nitric oxide as a candidate mediator of hypotension in response to 5-aminolevulinic acid in vitro in human umbilical vein endothelial cell cultures." | 8.12 | Association of 5-aminolevulinic acid with intraoperative hypotension in malignant glioma surgery. ( Fukuda, H; Fukuhara, H; Inoue, K; Ishida, T; Jobu, K; Kagimoto, N; Kawada, K; Kawanishi, Y; Masahira, N; Miyamura, M; Morisawa, S; Nakayama, T; Ogura, SI; Ohta, T; Takemura, M; Tamura, N; Ueba, T; Yamamoto, S, 2022) |
| "Intraoperative visualization of gliomas with 5-aminolevulinic acid (5-ALA) induced fluorescence constitutes a powerful technique." | 8.12 | Analysis of corticosteroid and antiepileptic drug treatment effects on heme biosynthesis mRNA expression in lower-grade gliomas: Potential implications for 5-ALA metabolization. ( Borkovec, M; Erhart, F; Hosmann, A; Kiesel, B; Lang, A; Makolli, J; Mischkulnig, M; Roetzer, T; Rössler, K; Sperl, V; Traxler, D; Wadiura, LI; Widhalm, G, 2022) |
| "A growing body of evidence has revealed the potential utility of 5-aminolevulinic acid (5-ALA) as a surgical adjunct in selected lower-grade gliomas." | 8.12 | A Data-Driven Approach to Predicting 5-Aminolevulinic Acid-Induced Fluorescence and World Health Organization Grade in Newly Diagnosed Diffuse Gliomas. ( Jaber, M; Johnson, TD; Müther, M; Orringer, DA; Stummer, W, 2022) |
| "5-Aminolevulinic acid (ALA) is an intraoperative molecular probe approved for fluorescence-guided resection (FGR) of high-grade gliomas to achieve maximal safe tumor resection." | 8.12 | Inhibition of ABCG2 transporter by lapatinib enhances 5-aminolevulinic acid-mediated protoporphyrin IX fluorescence and photodynamic therapy response in human glioma cell lines. ( Chandratre, S; Chen, B; Howley, R; Mansi, M, 2022) |
| "5-aminolevulinic acid (5-ALA) - precursor of protoporphyrin IX (PpIX) - is utilized in fluorescence guided surgery (FGS) of high-grade gliomas." | 8.12 | Detection improvement of gliomas in hyperspectral imaging of protoporphyrin IX fluorescence - in vitro comparison of visual identification and machine thresholds. ( Bednarik, R; Elomaa, AP; Haneishi, H; Hauta-Kasari, M; Immonen, A; Jääskeläinen, JE; Kämäräinen, OP; Lehtonen, SJR; Paterno, JJ; Puustinen, S; Vrzakova, H, 2022) |
| "5-Aminolevulinic acid (5-ALA) induces fluorescence in high-grade glioma (HGG), which is used for resection." | 8.12 | Fluorescence real-time kinetics of protoporphyrin IX after 5-ALA administration in low-grade glioma. ( Black, D; Kaneko, S; Schipmann, S; Sporns, P; Stummer, W; Suero Molina, E, 2022) |
| "5-Aminolevulinic Acid (5-ALA) photodiagnosis (PD) is an effective method to detect residual tumors during glioma surgery." | 8.02 | Ultrasound Modulates Fluorescence Strength and ABCG2 mRNA Response to Aminolevulinic Acid in Glioma Cells. ( Asakura, T; Higuchi, T; Morita, A; Oishi, Y; Yamaguchi, F; Yoshida, D, 2021) |
| " In Vitro assay revealed that mutant IDH indirectly reduced the amount of exogenous 5-ALA-derived protoporphyrinogen IX in glioma cells by increasing activity of ferrochelatase and heme oxygenase 1." | 7.96 | The Correlation of Fluorescence of Protoporphyrinogen IX and Status of Isocitrate Dehydrogenase in Gliomas. ( Abe, M; Adachi, K; Hasegawa, M; Hirose, Y; Kuwahara, K; Mukherjee, J; Murayama, K; Nakae, S; Nishiyama, Y; Ohba, S; Pareira, ES; Pieper, RO; Sasaki, H; Yamada, S; Yamamoto, N, 2020) |
| "5-aminolevulinic acid (5-ALA) has been increasingly used in recent years to identify anaplastic foci in primarily suspected low-grade gliomas (LGGs)." | 7.96 | Influence of Corticosteroids and Antiepileptic Drugs on Visible 5-Aminolevulinic Acid Fluorescence in a Series of Initially Suspected Low-Grade Gliomas Including World Health Organization Grade II, III, and IV Gliomas. ( Berger, MS; Borkovec, M; Furtner, J; Hervey-Jumper, S; Hosmann, A; Kiesel, B; Mercea, PA; Mischkulnig, M; Rössler, K; Rötzer, T; Wadiura, LI; Widhalm, G, 2020) |
| "Approximately 20% of low-grade gliomas (LGG) display visible protoporphyrin fluorescence during surgery after 5-aminolevulinic acid (5-ALA) administration." | 7.91 | Is Visible Aminolevulinic Acid-Induced Fluorescence an Independent Biomarker for Prognosis in Histologically Confirmed (World Health Organization 2016) Low-Grade Gliomas? ( Brokinkel, B; Ewelt, C; Grauer, O; Hasselblatt, M; Jaber, M; Stummer, W; Thomas, C; Wölfer, J, 2019) |
| "The aim of this study was to compare preoperative dual-time point F-fluorodeoxyglucose (FDG) uptake pattern with intraoperative 5-aminolevulinic acid (5-ALA) fluorescence in high-grade gliomas." | 7.91 | Comparison of dual-time point 18F-FDG PET/CT tumor-to-background ratio, intraoperative 5-aminolevulinic acid fluorescence scale, and Ki-67 index in high-grade glioma. ( Cho, KG; Jang, SJ; Kim, YI, 2019) |
| "Five-aminolevulinic acid (5-ALA) is well established for fluorescence-guided resections of malignant gliomas by eliciting the accumulation of fluorescent protoporphyrin IX (PpIX) in tumors." | 7.91 | Fluorescence-Based Measurement of Real-Time Kinetics of Protoporphyrin IX After 5-Aminolevulinic Acid Administration in Human In Situ Malignant Gliomas. ( Ewelt, C; Kaneko, S; Stummer, W; Suero Molina, E; Warneke, N, 2019) |
| "We sought to assess the impact of 5-aminolevulinic acid (5-ALA) and low-field intraoperative magnetic resonance imaging (iMRI) on the extent of resection of high-grade gliomas (HGGs)." | 7.91 | Combined Use of 5-Aminolevulinic Acid and Intraoperative Low-Field Magnetic Resonance Imaging in High-Grade Glioma Surgery. ( Bassaganyas-Vancells, C; Culebras, D; Enseñat, J; Ferrés, A; García, S; González, JJ; Hoyos, J; Reyes, L; Roldán, P; Torales, J, 2019) |
| " This study investigated the efficacy of 220-kHz TcMRgFUS combined with 5-aminolevulinic acid (5-ALA) on malignant glioma in vitro and in vivo." | 7.91 | Sonodynamic Therapy for Malignant Glioma Using 220-kHz Transcranial Magnetic Resonance Imaging-Guided Focused Ultrasound and 5-Aminolevulinic acid. ( Akahane, T; Brokman, O; Endo, S; Houkin, K; Itay, R; Kamada, H; Kato, Y; Kawase, Y; Kobayashi, H; Moriyama, K; Motegi, H; Shapira, Y; Suzuki, S; Terasaka, S; Yamaguchi, S; Yoshida, M, 2019) |
| "Surgery guided by 5-aminolevulinic acid (ALA) fluorescence has become a valuable adjunct in the resection of malignant intracranial gliomas." | 7.88 | Wavelength-specific lighted suction instrument for 5-aminolevulinic acid fluorescence-guided resection of deep-seated malignant glioma: technical note. ( Berger, MS; Han, SJ; Lau, D; Morshed, RA, 2018) |
| "5-Aminolevulinic Acid (5-ALA) induced fluorescence is useful in guiding glioma resection." | 7.88 | 5-Aminolevulinic acid fluorescence guided resection of malignant glioma: Hong Kong experience. ( Chan, DTM; Poon, WS; Yi-Pin Sonia, H, 2018) |
| "5-Aminolevulinic acid-induced PpIX fluorescence was assessed in GL261-Luc2 cells in vitro and in vivo after implantation in mouse brains, at an invading glioma growth stage, simulating residual tumor." | 7.88 | Scanning Fiber Endoscope Improves Detection of 5-Aminolevulinic Acid-Induced Protoporphyrin IX Fluorescence at the Boundary of Infiltrative Glioma. ( Belykh, E; Byvaltsev, VA; Hu, D; Martirosyan, NL; Miller, EJ; Nakaji, P; Nelson, LY; Preul, MC; Scheck, AC; Seibel, EJ; Woolf, EC, 2018) |
| " SFE may allow accurate imaging of 5-aminolevulinic acid labeling of gliomas and other tumor types when current detection techniques have failed to provide reliable visualization." | 7.88 | Scanning Fiber Endoscope Improves Detection of 5-Aminolevulinic Acid-Induced Protoporphyrin IX Fluorescence at the Boundary of Infiltrative Glioma. ( Belykh, E; Byvaltsev, VA; Hu, D; Martirosyan, NL; Miller, EJ; Nakaji, P; Nelson, LY; Preul, MC; Scheck, AC; Seibel, EJ; Woolf, EC, 2018) |
| "Fluorescence-guided surgery with protoporphyrin IX (PpIX) as a photodiagnostic marker is gaining acceptance for resection of malignant gliomas." | 7.88 | Scanning Fiber Endoscope Improves Detection of 5-Aminolevulinic Acid-Induced Protoporphyrin IX Fluorescence at the Boundary of Infiltrative Glioma. ( Belykh, E; Byvaltsev, VA; Hu, D; Martirosyan, NL; Miller, EJ; Nakaji, P; Nelson, LY; Preul, MC; Scheck, AC; Seibel, EJ; Woolf, EC, 2018) |
| "OBJECTIVE Fluorescence guidance with 5-aminolevulinic acid (5-ALA) helps improve resections of malignant gliomas." | 7.88 | Dual-labeling with 5-aminolevulinic acid and fluorescein for fluorescence-guided resection of high-grade gliomas: technical note. ( Brokinkel, B; Ehrhardt, A; Ewelt, C; Stummer, W; Suero Molina, E; Wölfer, J, 2018) |
| "The clinical efficacy of 5-aminolevulinic acid (5-ALA) for fluorescence-guided surgery of malignant gliomas is evident from several studies; however, as post-operative elevations of liver enzymes have been seen, there is a potential risk of liver damage upon administration." | 7.85 | Evaluation of the risk of liver damage from the use of 5-aminolevulinic acid for intra-operative identification and resection in patients with malignant gliomas. ( Offersen, CM; Skjoeth-Rasmussen, J, 2017) |
| "5-Aminolevulinic acid (5-ALA) can accumulate protoporphyrin IX (PpIX) in tumour cell mitochondria and is well known for its utility in fluorescence-guided resection of malignant gliomas as a live molecular marker." | 7.85 | 5-Aminolevulinic acid enhances mitochondrial stress upon ionizing irradiation exposure and increases delayed production of reactive oxygen species and cell death in glioma cells. ( Kitagawa, T; Nakano, Y; Nishizawa, S; Tanaka, T; Ueta, K; Yamamoto, J, 2017) |
| " 5-aminolevulinic acid (ALA) is metabolized to fluorescent protoporphyrin IX (PpIX) specifically in tumor cells, and therefore clinically used as a reagent for photodynamic diagnosis (PDD) and therapy (PDT) of cancers including gliomas." | 7.85 | Enhancement of 5-aminolevulinic acid-based fluorescence detection of side population-defined glioma stem cells by iron chelation. ( Hagiya, Y; Kokubu, Y; Murota, Y; Ogura, SI; Sugiyama, Y; Tabu, K; Taga, T; Wang, W, 2017) |
| "5-Aminolevulinic acid (5-ALA) has become an integral part in the neurosurgical treatment of malignant glioma." | 7.83 | 5-Aminolevulinic Acid Accumulation in a Cerebral Infarction Mimicking High-Grade Glioma. ( Behling, F; Bornemann, A; Hennersdorf, F; Skardelly, M; Tatagiba, M, 2016) |
| "This study evaluates the cost-effectiveness of 5-aminolevulinic acid (5-ALA, Gliolan®) in patients undergoing surgery for malignant glioma, in standard clinical practice conditions in Spain." | 7.81 | Cost-effectiveness of 5-aminolevulinic acid-induced fluorescence in malignant glioma surgery. ( Díez Valle, R; Galván, J; Slof, J, 2015) |
| "To evaluate the role of the neurochemical navigation with 5-aminolevulinic acid (5-ALA) during intraoperative MRI (iMRI)-guided resection of the intracranial malignant gliomas." | 7.81 | Role of neurochemical navigation with 5-aminolevulinic acid during intraoperative MRI-guided resection of intracranial malignant gliomas. ( Komori, T; Maruyama, T; Muragaki, Y; Okada, Y; Yamada, S, 2015) |
| "Previous studies have shown the individual benefits of 5-aminolevulinic acid (5-ALA) and intraoperative (i)MRI in enhancing survival for patients with high-grade glioma." | 7.81 | Outcomes after combined use of intraoperative MRI and 5-aminolevulinic acid in high-grade glioma surgery. ( Fandino, J; Fathi, AR; Landolt, H; Marbacher, S; Perrig, W; Remonda, L; Schatlo, B; Smoll, NR; Wetzel, O, 2015) |
| "Although 5-aminolevulinic acid (5-ALA)-mediated photodynamic therapy (PDT) has been demonstrated to be a novel and effective therapeutic modality for some human malignancies, its effect and mechanism on glioma are still controversial." | 7.81 | Photodynamic therapy mediated by 5-aminolevulinic acid suppresses gliomas growth by decreasing the microvessels. ( Chen, QX; Ji, BW; Liu, G; Okechi, H; Tian, DF; Wang, L; Wu, LQ; Xu, HT; Yi, W; Zhang, SQ; Zhu, XN, 2015) |
| "A 47-year-old man underwent 5-aminolevulinic acid assisted resection of high grade glioma." | 7.81 | Intra-operative acidosis during 5-aminolevulinic acid assisted glioma resection. ( Anderson, I; McKinlay, J; Naylor, T; Sivakumar, G, 2015) |
| "Fluorescence-guided surgery using 5-aminolevulinic acid (5-ALA) has become the main treatment modality in malignant gliomas." | 7.81 | Mechanism for enhanced 5-aminolevulinic acid fluorescence in isocitrate dehydrogenase 1 mutant malignant gliomas. ( Cho, HR; Choi, SH; Kim, H; Kim, JE; Kim, JY; Kim, SK; Lee, SH; Park, CK; Park, S; Park, SH; Xu, WJ, 2015) |
| "Previous studies in high-grade gliomas (HGGs) have indicated that protoporphyrin IX (PpIX) accumulates in higher concentrations in tumor tissue, and, when used to guide surgery, it has enabled improved resection leading to increased progression-free survival." | 7.81 | Quantitative fluorescence using 5-aminolevulinic acid-induced protoporphyrin IX biomarker as a surgical adjunct in low-grade glioma surgery. ( Harris, BT; Jacobs, V; Leblond, F; Paulsen, KD; Roberts, DW; Valdés, PA; Wilson, BC, 2015) |
| "To assess effectiveness of 5-aminolevulinic acid (5-ALA, Gliolan(®)) in patients treated for malignant glioma under typical daily practice conditions in Spain, using complete resection rate (CR) and progression free survival at 6 months (PFS6)." | 7.80 | Observational, retrospective study of the effectiveness of 5-aminolevulinic acid in malignant glioma surgery in Spain (The VISIONA study). ( Arza, C; Díez Valle, R; Galván, J; Romariz, C; Slof, J; Vidal, C, 2014) |
| " The study included adult patients with suspected malignant gliomas for whom the intended treatment plan included complete resection followed by radiotherapy and chemotherapy with temozolomide." | 7.80 | Observational, retrospective study of the effectiveness of 5-aminolevulinic acid in malignant glioma surgery in Spain (The VISIONA study). ( Arza, C; Díez Valle, R; Galván, J; Romariz, C; Slof, J; Vidal, C, 2014) |
| "To evaluate the use of 5-aminolevulinic acid (5-ALA) for the noninvasive detection of malignant gliomas by using in vivo magnetic resonance (MR) imaging in a mouse brain tumor model." | 7.80 | Malignant glioma: MR imaging by using 5-aminolevulinic acid in an animal model. ( Bishop, D; Cho, HR; Choi, SH; Doble, P; Han, MH; Hare, D; Kim, D; Kim, DH; Moon, WK; Park, CK, 2014) |
| "We investigated the association between the cell density and intensity of 5-aminolevulinic acid-induced fluorescence of protoporphyrin IX in 3-dimensionally cultured C6 glioma cells." | 7.80 | [Determining the tumor-cell density required for macroscopic observation of 5-ALA-induced fluorescence of protoporphyrin IX in cultured glioma cells and clinical cases]. ( Andriana, B; Hashimoto, N; Kikuta, K; Kitai, R; Miyoshi, N; Neishi, H; Takeuchi, H, 2014) |
| "Only few data are available on the specific topic of 5-aminolevulinic acid (5-ALA) guided surgery of high-grade gliomas (HGG) located in eloquent areas." | 7.79 | 5-aminolevulinic acid (5-ALA) fluorescence guided surgery of high-grade gliomas in eloquent areas assisted by functional mapping. Our experience and review of the literature. ( d'Avella, E; De Pellegrin, S; Della Puppa, A; Gerardi, A; Gioffrè, G; Lombardi, G; Manara, R; Munari, M; Rossetto, M; Saladini, M; Scienza, R, 2013) |
| "Among glioma treatment strategies, 5-aminolevulinic acid (5-ALA)-based fluorescence-guided resection (FGR) and photodynamic therapy (PDT) have been used as effective novel approaches against malignant glioma." | 7.79 | Low-dose arsenic trioxide enhances 5-aminolevulinic acid-induced PpIX accumulation and efficacy of photodynamic therapy in human glioma. ( Chen, X; Fu, C; Gao, C; Han, D; Ji, Z; Li, H; Li, X; Liu, H; Liu, Y; Liu, Z; Shi, H; Wang, C; Wang, L; Wu, J; Yang, G; Yin, F; Zhang, D; Zhao, S, 2013) |
| "These results indicate that 5-ALA fluorescence and (11) C-methionine PET image are separate index markers for cytoreduction surgery of gliomas." | 7.78 | ¹¹C-methionine uptake and intraoperative 5-aminolevulinic acid-induced fluorescence as separate index markers of cell density in glioma: a stereotactic image-histological analysis. ( Arita, H; Fujimoto, Y; Hashimoto, N; Kagawa, N; Kinoshita, M; Kishima, H; Yoshimine, T, 2012) |
| "5-Aminolevulinic acid (ALA) is a prodrug used in photodynamic therapy and fluorescence-guided resection of malignant gliomas due to its high cellular uptake in tumours." | 7.78 | Radiosensitizing effect of 5-aminolevulinic acid-induced protoporphyrin IX in glioma cells in vitro. ( Akiba, D; Kitagawa, T; Nakano, Y; Nishizawa, S; Ogura, S; Saito, T; Takahashi, M; Tanaka, T; Yamamoto, J, 2012) |
| "In recent years, 5-aminolevulinic acid (ALA)-induced protoporphyrin IX (PpIX) fluorescence guidance has been used as a surgical adjunct to improve the extent of resection of gliomas." | 7.78 | Gadolinium- and 5-aminolevulinic acid-induced protoporphyrin IX levels in human gliomas: an ex vivo quantitative study to correlate protoporphyrin IX levels and blood-brain barrier breakdown. ( Belden, CJ; Harris, BT; Kim, A; Moses, ZB; Paulsen, KD; Roberts, DW; Valdés, PA; Wilson, BC, 2012) |
| "The sonodynamically induced selective antitumor effects of 5-aminolevulinic acid (5-ALA) on a C6 glioma that was implanted in a rat brain were evaluated." | 7.78 | Sonodynamically induced antitumor effects of 5-aminolevulinic acid and fractionated ultrasound irradiation in an orthotopic rat glioma model. ( Ahn, YJ; Choi, KH; Jeong, EJ; Kim, JK; Kim, KH; Seo, SJ, 2012) |
| "Photodynamic therapy (PDT) using 5-aminolevulinic acid (5-ALA) is a new therapeutic modality for malignant glioma." | 7.77 | Morphological and histological changes of glioma cells immediately after 5-aminolevulinic acid mediated photodynamic therapy. ( Iwasaki, Y; Kamoshima, Y; Kuroda, S; Terasaka, S, 2011) |
| "The photodynamic therapy using 5-aminolevulinic acid is one of the new therapeutic modalities for malignant glioma yet." | 7.74 | [Photodynamic therapy mediated with 5-aminolevulinic acid for C6 glioma spheroids]. ( Iwasaki, Y; Kamoshima, Y; Terasaka, S, 2008) |
| "The basic mechanism of cell death induced by 5-aminolevulinic acid (5-ALA)-mediated photodynamic therapy (PDT) (ALA-PDT) in glioma cells has not been fully elucidated." | 7.74 | Massive apoptotic cell death of human glioma cells via a mitochondrial pathway following 5-aminolevulinic acid-mediated photodynamic therapy. ( Inoue, H; Kajimoto, Y; Kuroiwa, T; Miyatake, S; Miyoshi, N; Ogawa, N; Otsuki, Y; Shibata, MA, 2007) |
| " The purpose of this study was to investigate the anti-tumor effects of concurrent 5-aminolevulinic acid (ALA)-mediated PDT and hyperthermia (HT) in human and rat glioma spheroids." | 7.72 | Enhanced cytotoxic effects of 5-aminolevulinic acid-mediated photodynamic therapy by concurrent hyperthermia in glioma spheroids. ( Hirschberg, H; Madsen, SJ; Sun, CH; Tromberg, BJ; Yeh, AT, 2004) |
| "Accumulation of protoporphyrin IX (PPIX) in malignant gliomas is induced by 5-aminolevulinic acid (5-ALA)." | 7.71 | Photoirradiation therapy of experimental malignant glioma with 5-aminolevulinic acid. ( Bise, K; Hundt, CS; Olzowy, B; Reulen, HJ; Stocker, S; Stummer, W, 2002) |
| "Our observations suggest that 5-aminolevulinic acid-induced porphyrin fluorescence may label malignant gliomas safely and accurately enough to enhance the completeness of tumor removal." | 7.70 | Intraoperative detection of malignant gliomas by 5-aminolevulinic acid-induced porphyrin fluorescence. ( Fritsch, C; Goetz, AE; Goetz, C; Kiefmann, R; Reulen, HJ; Stepp, H; Stocker, S; Stummer, W; Wagner, S, 1998) |
| "High-grade glioma is the most common malignant primary brain tumor in adults." | 6.82 | 5-Aminolevulinic Acid Imaging of Malignant Glioma. ( Garcia, C; Hayden-Gephart, M; Jain, S; Kim, L; Li, G; Rodrigues, A; Zhang, M, 2022) |
| " Clinical trials of 5-ALA RDT for HGG are needed to evaluate the optimum timing, dosing and effectiveness." | 6.72 | 5-Aminolevulinic acid radiodynamic therapy for treatment of high-grade gliomas: A systematic review. ( Michael, AP; Nordmann, NJ, 2021) |
| "5-Aminolevulinic acid is a non-fluorescent prodrug that leads to intracellular accumulation of fluorescent porphyrins in malignant gliomas-a finding that is under investigation for intraoperative identification and resection of these tumours." | 6.72 | Fluorescence-guided surgery with 5-aminolevulinic acid for resection of malignant glioma: a randomised controlled multicentre phase III trial. ( Meinel, T; Pichlmeier, U; Reulen, HJ; Stummer, W; Wiestler, OD; Zanella, F, 2006) |
| "5-Aminolevulinic acid (ALA) has been widely used as an intravital fluorescence marker in the fluorescence-guided resection of malignant gliomas." | 6.66 | 5-Aminolevulinic Acid: Pitfalls of Fluorescence-guided Resection for Malignant Gliomas and Application for Malignant Glioma Therapy. ( Kitagawa, T; Miyaoka, R; Nakano, Y; Saito, T; Suzuki, K; Takamatsu, S; Yamamoto, J, 2020) |
| "Gliomas are molecularly complex neoplasms and require a multidisciplinary approach to treatment." | 6.61 | Following the light in glioma surgery: a comparison of sodium fluorescein and 5-aminolevulinic acid as surgical adjuncts in glioma resection. ( Brown, DA; Chaichana, KL; Navarro-Bonnet, J; Quinones-Hinojosa, A; Suarez-Meade, P, 2019) |
| "Fluorescence-guided surgery for brain tumors is a contemporary adjuvant technique that allows for intraoperative delineation of diseased and normal brain thus improving maximal safe resection." | 6.61 | Following the light in glioma surgery: a comparison of sodium fluorescein and 5-aminolevulinic acid as surgical adjuncts in glioma resection. ( Brown, DA; Chaichana, KL; Navarro-Bonnet, J; Quinones-Hinojosa, A; Suarez-Meade, P, 2019) |
| "5-Aminolevulinic acid (5-ALA) is a prodrug preferentially metabolized by glioma cells that allows direct, real-time visualization of pathologic tissue through fluorescence under blue light." | 6.61 | The impact of 5-aminolevulinic acid on extent of resection in newly diagnosed high grade gliomas: a systematic review and single institutional experience. ( Haider, SA; Kalkanis, SN; Lee, IY; Lim, S, 2019) |
| "5-Aminolevulinic acid (5-ALA) has been approved as an intraoperative adjunct in glioma surgery in Europe, but not North America." | 6.53 | The role of 5-aminolevulinic acid in enhancing surgery for high-grade glioma, its current boundaries, and future perspectives: A systematic review. ( Bernstein, M; Hachem, LD; Klironomos, G; Mansouri, A; Mansouri, S; Vogelbaum, MA; Zadeh, G, 2016) |
| "Malignant gliomas are locally invasive tumors that offer a poor prognosis." | 6.53 | Selective 5-aminolevulinic acid-induced protoporphyrin IX fluorescence in Gliomas. ( Ma, R; Watts, C, 2016) |
| "5-aminolevulinic acid (ALA) is a precursor of haemoglobin which leads to the synthesis of porphyrins in malignant gliomas which then appears with red fluorescence under blue light." | 6.49 | [Fluorescence-guided surgery with 5-aminolevulinic acid for resection of malignant gliomas--a new treatment modality]. ( Cortnum, S; Laursen, R, 2013) |
| "Gliomas are diffuse intra-axial lesions, which can be accessed by multiple surgical corridors for a same location depending on the surgeon's preference." | 5.91 | Supraorbital transciliary approach as primary route to fronto-basal high grade glioma resection with 5-Aminolevulinic Acid use: Technical note. ( Aboukaïs, R; Bourgeois, P; Devalckeneer, A; Lejeune, JP; Reyns, N, 2023) |
| "According to in vitro results, the low blood pressure induced by 5-aminolevulinic acid may be mediated by a nitric oxide increase in vascular endothelial cells." | 5.72 | Association of 5-aminolevulinic acid with intraoperative hypotension in malignant glioma surgery. ( Fukuda, H; Fukuhara, H; Inoue, K; Ishida, T; Jobu, K; Kagimoto, N; Kawada, K; Kawanishi, Y; Masahira, N; Miyamura, M; Morisawa, S; Nakayama, T; Ogura, SI; Ohta, T; Takemura, M; Tamura, N; Ueba, T; Yamamoto, S, 2022) |
| "5-Aminolevulinic acid (ALA) is an intraoperative molecular probe approved for fluorescence-guided resection (FGR) of high-grade gliomas to achieve maximal safe tumor resection." | 5.72 | Inhibition of ABCG2 transporter by lapatinib enhances 5-aminolevulinic acid-mediated protoporphyrin IX fluorescence and photodynamic therapy response in human glioma cell lines. ( Chandratre, S; Chen, B; Howley, R; Mansi, M, 2022) |
| "5-aminolevulinic acid (5-ALA) has been increasingly used in recent years to identify anaplastic foci in primarily suspected low-grade gliomas (LGGs)." | 5.56 | Influence of Corticosteroids and Antiepileptic Drugs on Visible 5-Aminolevulinic Acid Fluorescence in a Series of Initially Suspected Low-Grade Gliomas Including World Health Organization Grade II, III, and IV Gliomas. ( Berger, MS; Borkovec, M; Furtner, J; Hervey-Jumper, S; Hosmann, A; Kiesel, B; Mercea, PA; Mischkulnig, M; Rössler, K; Rötzer, T; Wadiura, LI; Widhalm, G, 2020) |
| "High-grade gliomas are a type of malignant brain tumour." | 5.56 | 5-Aminolevulinic Acid Hydrochloride (5-ALA)-Guided Surgical Resection of High-Grade Gliomas: A Health Technology Assessment. ( , 2020) |
| "Fluorescein has recently been reintroduced into neurosurgery, and novel microscope systems are available for visualizing this fluorochrome, which highlights all perfused tissues but has limited selectivity for tumor detection." | 5.48 | Dual-labeling with 5-aminolevulinic acid and fluorescein for fluorescence-guided resection of high-grade gliomas: technical note. ( Brokinkel, B; Ehrhardt, A; Ewelt, C; Stummer, W; Suero Molina, E; Wölfer, J, 2018) |
| "High-grade glioma is a very aggressive and infiltrative tumor in which complete resection is a chance for a better outcome." | 5.46 | 18F-Fluorocholine PET/CT, Brain MRI, and 5-Aminolevulinic Acid for the Assessment of Tumor Resection in High-Grade Glioma. ( Borrás Moreno, JM; García Vicente, AM; Jiménez Aragón, F; Jiménez Londoño, GA; Villena Martín, M, 2017) |
| " No severe adverse effects were reported." | 5.43 | Safety and Efficacy of 5-Aminolevulinic Acid for High Grade Glioma in Usual Clinical Practice: A Prospective Cohort Study. ( Arráez, MÁ; Garcia, R; González, JJ; Montané, E; Rimbau, J; Tardáguila, M; Teixidor, P; Vidal, X; Villalba, G, 2016) |
| "5-Aminolevulinic acid (5-ALA) has become an integral part in the neurosurgical treatment of malignant glioma." | 5.43 | 5-Aminolevulinic Acid Accumulation in a Cerebral Infarction Mimicking High-Grade Glioma. ( Behling, F; Bornemann, A; Hennersdorf, F; Skardelly, M; Tatagiba, M, 2016) |
| "High-grade gliomas are aggressive, incurable tumors characterized by extensive diffuse invasion of the normal brain parenchyma." | 5.42 | A pilot cost-effectiveness analysis of treatments in newly diagnosed high-grade gliomas: the example of 5-aminolevulinic Acid compared with white-light surgery. ( Alves, M; Castel-Branco, M; Esteves, S; Stummer, W, 2015) |
| "Independently, both 5-aminolevulinic acid (5-ALA) and intraoperative neuromonitoring (IONM) have been shown to improve outcomes with high-grade gliomas (HGG)." | 5.41 | Resection of the contrast-enhancing tumor in diffuse gliomas bordering eloquent areas using electrophysiology and 5-ALA fluorescence: evaluation of resection rates and neurological outcome-a systematic review and meta-analysis. ( Conti, A; Halimi, F; Levivier, M; Ozduman, K; Peters, DR; Reyns, N; Tuleasca, C, 2023) |
| "In all groups except low-grade glioma, fluorescence was present after 5-ala administration; fluorescence was present for all groups after fluorescein administration." | 5.41 | Intraoperative Fluorophores: An Update on 5-Aminolevulinic Acid and Sodium Fluorescein in Resection of Tumors of the Central Nervous System and Metastatic Lesions-A Systematic Review and Meta-Analysis. ( Andaluz, N; Ivey, N; Matur, A; Shah, S, 2023) |
| "Also, calcitriol pretreated glioma cells exhibited increased cell death following ALA-based photodynamic therapy." | 5.40 | Calcitriol enhances 5-aminolevulinic acid-induced fluorescence and the effect of photodynamic therapy in human glioma. ( Chen, X; Fu, C; Guan, H; Li, X; Liu, H; Liu, Y; Liu, Z; Teng, L; Wang, C; Wang, L; Yang, G; Yin, F; Zhang, D; Zhang, Y; Zhao, B; Zhao, S, 2014) |
| "This finding suggests that the combined treatment of glioma cells with calcitriol plus ALA may provide an effective and selective therapeutic modality to enhance ALA-induced PpIX fluorescent quality for improving discrimination of tumor tissue and PDT efficacy." | 5.40 | Calcitriol enhances 5-aminolevulinic acid-induced fluorescence and the effect of photodynamic therapy in human glioma. ( Chen, X; Fu, C; Guan, H; Li, X; Liu, H; Liu, Y; Liu, Z; Teng, L; Wang, C; Wang, L; Yang, G; Yin, F; Zhang, D; Zhang, Y; Zhao, B; Zhao, S, 2014) |
| "5-Aminolevulinic acid (ALA) is a prodrug used in photodynamic therapy and fluorescence-guided resection of malignant gliomas due to its high cellular uptake in tumours." | 5.38 | Radiosensitizing effect of 5-aminolevulinic acid-induced protoporphyrin IX in glioma cells in vitro. ( Akiba, D; Kitagawa, T; Nakano, Y; Nishizawa, S; Ogura, S; Saito, T; Takahashi, M; Tanaka, T; Yamamoto, J, 2012) |
| "5-Aminolevulinic acid (5-ALA) has already been applied clinically as a photosensitizer." | 5.37 | Sonodynamic therapy with 5-aminolevulinic acid and focused ultrasound for deep-seated intracranial glioma in rat. ( Fukushima, T; Inoue, T; Kuroki, M; Ohmura, T; Sasaki, K; Shibaguchi, H; Umemura, S; Yoshizawa, S, 2011) |
| "Malignant gliomas are highly infiltrative tumours with a fatal prognosis." | 5.35 | Association of F18-fluoro-ethyl-tyrosin uptake and 5-aminolevulinic acid-induced fluorescence in gliomas. ( Fonyuy, N; Horn, P; Koch, A; Misch, M; Plotkin, M; Stockhammer, F, 2009) |
| " The proportion of dead cells increased with increases in the dosage of light." | 5.34 | Massive apoptotic cell death of human glioma cells via a mitochondrial pathway following 5-aminolevulinic acid-mediated photodynamic therapy. ( Inoue, H; Kajimoto, Y; Kuroiwa, T; Miyatake, S; Miyoshi, N; Ogawa, N; Otsuki, Y; Shibata, MA, 2007) |
| "5-Aminolevulinic acid (ALA) has shown promising in photodynamic detection and therapy of brain tumor." | 5.32 | Protoporphyrin IX production and its photodynamic effects on glioma cells, neuroblastoma cells and normal cerebellar granule cells in vitro with 5-aminolevulinic acid and its hexylester. ( Chen, JY; Peng, Q; Ren, QG; Wu, SM; Zhou, MO, 2003) |
| "OBJECTIVE The objective of this study was to detect 5-aminolevulinic acid (ALA)-induced tumor fluorescence from glioma below the surface of the surgical field by using red-light illumination." | 5.27 | Red-light excitation of protoporphyrin IX fluorescence for subsurface tumor detection. ( Bravo, JJ; Evans, LT; Fan, X; Kanick, SC; Kolste, KK; Leblond, F; Marois, M; Olson, JD; Paulsen, KD; Roberts, DW; Wilson, BC, 2018) |
| "Five-aminolevulinic acid (5-ALA) is used for fluorescence-guided resections of malignant glioma at a dose of 20 mg/kg; yet, it is unknown whether lower doses may also provide efficacy." | 5.24 | Randomized, Prospective Double-Blinded Study Comparing 3 Different Doses of 5-Aminolevulinic Acid for Fluorescence-Guided Resections of Malignant Gliomas. ( Pichlmeier, U; Stepp, H; Stummer, W; Wiestler, OD, 2017) |
| "The utility of oral 5-aminolevulinic acid (5-ALA)/protoporphyrin fluorescence for the resection of high-grade gliomas is well documented." | 5.24 | A Phase 1 Dose-Escalation Study of Oral 5-Aminolevulinic Acid in Adult Patients Undergoing Resection of a Newly Diagnosed or Recurrent High-Grade Glioma. ( Amin, DV; Cozzens, JW; Espinosa, JA; Jones, BA; Lokaitis, BC; MacGregor, M; Michael, AP; Moore, BE, 2017) |
| "Fluorescence-guided surgery with 5-aminolevulinic acid (5-ALA) is used to assist brain tumor resection, especially for high-grade gliomas but also for low-grade gliomas, metastasis, and meningiomas." | 5.22 | 5-Aminolevulinic acid fluorescence in brain non-neoplastic lesions: a systematic review and case series. ( Cavalcanti, MS; da Silva, EB; de Almeida Teixeira, BC; Duarte, JFS; Jung, GS; Ramina, R, 2022) |
| "5-aminolevulinic acid (5-ALA) has demonstrated its utility as an intraoperative imaging adjunct during fluorescence guided resection of malignant gliomas." | 5.22 | Utility of 5-ALA for fluorescence-guided resection of brain metastases: a systematic review. ( Ben-Shalom, N; D'Amico, RS; Khilji, H; Leskinen, S; Narayan, V; Shah, HA, 2022) |
| "OBJECT There is evidence that 5-aminolevulinic acid (ALA) facilitates greater extent of resection and improves 6-month progression-free survival in patients with high-grade gliomas." | 5.22 | A prospective Phase II clinical trial of 5-aminolevulinic acid to assess the correlation of intraoperative fluorescence intensity and degree of histologic cellularity during resection of high-grade gliomas. ( Berger, MS; Chang, S; Hervey-Jumper, SL; Lau, D; McDermott, MW; Molinaro, AM; Phillips, JJ, 2016) |
| "5-Aminolevulinic acid (5-ALA) fluorescence is a validated technique for resection of high grade gliomas (HGG); the aim of this study was to evaluate the surgical outcome and the intraoperative findings in a consecutive series of patients." | 5.19 | 5-Aminolevulinic acid fluorescence in high grade glioma surgery: surgical outcome, intraoperative findings, and fluorescence patterns. ( Cecchin, D; Ciccarino, P; Della Puppa, A; Lombardi, G; Rolma, G; Rossetto, M, 2014) |
| "The aim of the study was to compare presurgical (18)F-fluoroethyl-L: -tyrosine ((18)F-FET) uptake and Gd-diethylenetriaminepentaacetic acid (DTPA) enhancement on MRI (Gd) with intraoperative 5-aminolevulinic acid (5-ALA) fluorescence in cerebral gliomas." | 5.15 | Comparison of (18)F-FET PET and 5-ALA fluorescence in cerebral gliomas. ( Coenen, HH; Ewelt, C; Felsberg, J; Floeth, FW; Langen, KJ; Reifenberger, G; Sabel, M; Steiger, HJ; Stoffels, G; Stummer, W, 2011) |
| " Qualitative fluorescence of protoporphyrin IX (PpIX), synthesized endogenously following δ-aminolevulinic acid (ALA) administration, has been used for this purpose in high-grade glioma (HGG)." | 5.15 | Quantitative fluorescence in intracranial tumor: implications for ALA-induced PpIX as an intraoperative biomarker. ( Erkmen, K; Fan, X; Harris, BT; Hartov, A; Ji, S; Kim, A; Leblond, F; Paulsen, KD; Roberts, DW; Simmons, NE; Tosteson, TD; Valdés, PA; Wilson, BC, 2011) |
| "5-Aminolevulinic acid is a non-fluorescent prodrug that leads to intracellular accumulation of fluorescent porphyrins in malignant gliomas-a finding that is under investigation for intraoperative identification and resection of these tumours." | 5.12 | Fluorescence-guided surgery with 5-aminolevulinic acid for resection of malignant glioma: a randomised controlled multicentre phase III trial. ( Meinel, T; Pichlmeier, U; Reulen, HJ; Stummer, W; Wiestler, OD; Zanella, F, 2006) |
| "322 patients aged 23-73 years with suspected malignant glioma amenable to complete resection of contrast-enhancing tumour were randomly assigned to 20 mg/kg bodyweight 5-aminolevulinic acid for fluorescence-guided resection (n=161) or to conventional microsurgery with white light (n=161)." | 5.12 | Fluorescence-guided surgery with 5-aminolevulinic acid for resection of malignant glioma: a randomised controlled multicentre phase III trial. ( Meinel, T; Pichlmeier, U; Reulen, HJ; Stummer, W; Wiestler, OD; Zanella, F, 2006) |
| "Tumour fluorescence derived from 5-aminolevulinic acid enables more complete resections of contrast-enhancing tumour, leading to improved progression-free survival in patients with malignant glioma." | 5.12 | Fluorescence-guided surgery with 5-aminolevulinic acid for resection of malignant glioma: a randomised controlled multicentre phase III trial. ( Meinel, T; Pichlmeier, U; Reulen, HJ; Stummer, W; Wiestler, OD; Zanella, F, 2006) |
| "Oral application of 20 mg/kg body weight of 5-aminolevulinic acid (ALA) leads to a highly specific accumulation of fluorescent Protoporphyrin IX (PPIX) in malignant glioma tissue." | 5.12 | ALA and malignant glioma: fluorescence-guided resection and photodynamic treatment. ( Beck, T; Kreth, FW; Meinel, T; Pongratz, T; Stepp, H; Stummer, W; Tonn, JCh, 2007) |
| "For optimizing high-grade glioma resection, 5-aminolevulinic acid is a reliable tool." | 5.05 | The Use of 5-Aminolevulinic Acid in Low-Grade Glioma Resection: A Systematic Review. ( Abi-Aad, KR; Abunimer, AM; Almekkawi, AK; Aoun, SG; Bendok, BR; El Ahmadieh, TY; El Tecle, NE; Patel, T; Plitt, AR; Stummer, W; Wu, EM, 2020) |
| "To study the role of 5-aminolevulinic acid in low-grade glioma resection and assess positive fluorescence rates and the effect on the extent of resection." | 5.05 | The Use of 5-Aminolevulinic Acid in Low-Grade Glioma Resection: A Systematic Review. ( Abi-Aad, KR; Abunimer, AM; Almekkawi, AK; Aoun, SG; Bendok, BR; El Ahmadieh, TY; El Tecle, NE; Patel, T; Plitt, AR; Stummer, W; Wu, EM, 2020) |
| " Studies that correlated 5-aminolevulinic acid fluorescence with low-grade glioma in the setting of operative resection were selected." | 5.05 | The Use of 5-Aminolevulinic Acid in Low-Grade Glioma Resection: A Systematic Review. ( Abi-Aad, KR; Abunimer, AM; Almekkawi, AK; Aoun, SG; Bendok, BR; El Ahmadieh, TY; El Tecle, NE; Patel, T; Plitt, AR; Stummer, W; Wu, EM, 2020) |
| "There is an overall low correlation between 5-aminolevulinic acid fluorescence and low-grade glioma." | 5.05 | The Use of 5-Aminolevulinic Acid in Low-Grade Glioma Resection: A Systematic Review. ( Abi-Aad, KR; Abunimer, AM; Almekkawi, AK; Aoun, SG; Bendok, BR; El Ahmadieh, TY; El Tecle, NE; Patel, T; Plitt, AR; Stummer, W; Wu, EM, 2020) |
| "One of the most valuable innovations in high-grade glioma surgery is 5-aminolevulinic acid (5-ALA)." | 5.05 | 5-Aminolevulinic Acid False Positives in Cerebral Neuro-Oncology: Not All That Is Fluorescent Is Tumor. A Case-Based Update and Literature Review. ( Altieri, R; Barresi, V; Della Pepa, GM; Ius, T; La Rocca, G; Marchese, E; Menna, G; Olivi, A; Sabatino, G, 2020) |
| "5-Aminolevulinic acid (ALA) has been widely used as an intravital fluorescence marker in the fluorescence-guided resection of malignant gliomas." | 5.05 | 5-Aminolevulinic Acid: Pitfalls of Fluorescence-guided Resection for Malignant Gliomas and Application for Malignant Glioma Therapy. ( Kitagawa, T; Miyaoka, R; Nakano, Y; Saito, T; Suzuki, K; Takamatsu, S; Yamamoto, J, 2020) |
| " Search terms include "glioma" and "aminolevulinic acid"." | 5.05 | 5-Aminolevulinic acid for recurrent malignant gliomas: A systematic review. ( Broekx, S; De Vleeschouwer, S; Weyns, F, 2020) |
| "Fluorescence guided surgery (FGS) with five-aminolevulinic acid (5-ALA) is expected to revolutionize neurosurgical care of patients with high-grade gliomas (HGG)." | 5.01 | 5-Aminolevulinic acid fluorescence guided surgery for recurrent high-grade gliomas. ( Berger, MS; Chohan, MO, 2019) |
| "This review describes the existing literature discussing the utilization of 5-aminolevulinic acid for fluorescence guided surgery in low-grade gliomas, including its pertinence in identification of anaplastic foci and potential role in guiding resection following combination with augmentation strategies for detection." | 5.01 | Fluorescence-guided surgery with aminolevulinic acid for low-grade gliomas. ( Hendricks, BK; Sanai, N; Stummer, W, 2019) |
| "The advance in operative technology and growth of research analyzing 5-aminolevulinic acid will continue to enhance the role of fluorescence guided surgery within the standard of surgical management for low-grade gliomas." | 5.01 | Fluorescence-guided surgery with aminolevulinic acid for low-grade gliomas. ( Hendricks, BK; Sanai, N; Stummer, W, 2019) |
| "Fluorescence guided surgery by 5-aminolevulinic acid (5-ALA) and intraoperative MRI (iMRI) are currently the most important intraoperative imaging techniques in high grade glioma (HGG) surgery." | 5.01 | Fluorescence guided surgery by 5-ALA and intraoperative MRI in high grade glioma: a systematic review. ( Coburger, J; Wirtz, CR, 2019) |
| "5-aminolevulinic acid (5-ALA) was approved by the FDA in June 2017 as an intra-operative optical imaging agent for patients with gliomas (suspected World Health Organization Grades III or IV on preoperative imaging) as an adjunct for the visualization of malignant tissue during surgery." | 5.01 | Established and emerging uses of 5-ALA in the brain: an overview. ( Díez Valle, R; Hadjipanayis, CG; Stummer, W, 2019) |
| " 5-aminolevulinic acid (5-ALA), an intermediate in the heme synthesis pathway, is a photosensitizing precursor with FDA approval for PDT of actinic keratosis and as an intraoperative imaging agent for fluorescence-guided visualization of malignant tissue during glioma surgery." | 5.01 | 5-aminolevulinic acid photodynamic therapy for the treatment of high-grade gliomas. ( Bouras, A; Bozec, D; Busch, TM; Cramer, G; Garvey, KL; Hadjipanayis, CG; Jesu Raj, JG; Mahmoudi, K; Stepp, H, 2019) |
| "5-Aminolevulinic acid (5-ALA)-guided resection of gliomas in adults enables better differentiation between tumor and normal brain tissue, allowing a higher degree of resection, and improves patient outcomes." | 5.01 | 5-ALA fluorescence-guided surgery in pediatric brain tumors-a systematic review. ( Brentrup, A; Köchling, M; Müther, M; Schipmann, S; Schwake, M; Stummer, W, 2019) |
| "Fluorescence guided surgery with 5-aminolevulinic acid (5-ALA) is a well-established technique for improving resection of malignant cerebral glioma." | 5.01 | 5-ALA fluorescence on tumors different from malignant gliomas. Review of the literature and our experience. ( Boschi, A; Della Puppa, A, 2019) |
| "5-aminolevulinic acid (5-ALA) is a prodrug that results in the fluorescence of high-grade gliomas relative to the surrounding brain parenchyma." | 4.98 | Fluorescence-guided surgery for high-grade gliomas. ( Hadjipanayis, CG; Lakomkin, N, 2018) |
| " 5-Aminolevulinic acid, useful for malignant gliomas and other tumors, is the most broadly explored compound approved for fluorescence-guided resection." | 4.95 | Fluorescence Imaging/Agents in Tumor Resection. ( Stummer, W; Suero Molina, E, 2017) |
| "5-Aminolevulinic acid (5-ALA) has been approved as an intraoperative adjunct in glioma surgery in Europe, but not North America." | 4.93 | The role of 5-aminolevulinic acid in enhancing surgery for high-grade glioma, its current boundaries, and future perspectives: A systematic review. ( Bernstein, M; Hachem, LD; Klironomos, G; Mansouri, A; Mansouri, S; Vogelbaum, MA; Zadeh, G, 2016) |
| " 5-Aminolevulinic acid (ALA) induced protoporphyrin IX (PpIX) has proven its rational in fluoro-guided resection of malignant gliomas due to a selective tumor uptake and minimal skin sensitization." | 4.90 | Experimental use of photodynamic therapy in high grade gliomas: a review focused on 5-aminolevulinic acid. ( Lejeune, JP; Mordon, S; Reyns, N; Tetard, MC; Vermandel, M, 2014) |
| "5-aminolevulinic acid (ALA) is a precursor of haemoglobin which leads to the synthesis of porphyrins in malignant gliomas which then appears with red fluorescence under blue light." | 4.89 | [Fluorescence-guided surgery with 5-aminolevulinic acid for resection of malignant gliomas--a new treatment modality]. ( Cortnum, S; Laursen, R, 2013) |
| "We performed a systematic review and meta-analysis to address the (added) value of intraoperative 5-aminolevulinic acid (5-ALA)-guided resection of high-grade malignant gliomas compared with conventional neuronavigation-guided resection, with respect to diagnostic accuracy, extent of tumor resection, safety, and survival." | 4.89 | Intraoperative fluorescence-guided resection of high-grade malignant gliomas using 5-aminolevulinic acid-induced porphyrins: a systematic review and meta-analysis of prospective studies. ( Chen, X; Dong, X; Han, D; Li, H; Liu, H; Liu, Y; Shen, C; Shi, C; Teng, L; Wang, C; Wang, L; Wu, J; Yang, G; Zhao, S, 2013) |
| "The importance of the extent of resection for gliomas, and the utility of aminolevulinic acid (ALA) and protoporphyrin IX fluorescence in increasing the extent of resection, has become increasingly evident over the past decade." | 4.88 | Aminolevulinic acid (ALA)-protoporphyrin IX fluorescence guided tumour resection. Part 2: theoretical, biochemical and practical aspects. ( Colditz, MJ; Jeffree, RL; Leyen, Kv, 2012) |
| "Conventionary, we use 5-aminolevulinic acid (5-ALA) for photo-dynamic diagnosis in the removal of malignant gliomas." | 4.85 | [Intraoperative photo-dynamic diagnosis of brain tumors]. ( Kajimoto, Y; Kuroiwa, T; Miyatake, S, 2009) |
| "A case of low-grade glioma in which 5-aminolevulinic acid (5-ALA) fluorescence was visualized by a digital exoscope is presented." | 4.31 | 5-ALA fluorescence-guided resection of pediatric low-grade glioma using the ORBEYE 3D digital exoscope: a technical report. ( Asai, A; Kamei, T; Maeda, M; Naito, N; Nonaka, M; Ueno, K, 2023) |
| "Fluorescence-guided surgery applying 5-aminolevulinic acid (5-ALA) in high-grade gliomas is an established method in adults." | 4.31 | 5-ALA fluorescence in randomly selected pediatric brain tumors assessed by spectroscopy and surgical microscope. ( Haj-Hosseini, N; Hillman, J; Milos, P; Wårdell, K, 2023) |
| " This study investigated the efficacy of 5-aminolevulinic acid-mediated photodynamic therapy (ALA-PDT) in destructing glioma stem cells (GSCs), including the mesenchymal subtype (MES-GSCs) demonstrated to have the lowest radio- and chemosensitivity." | 4.31 | Ablation efficacy of 5-aminolevulinic acid-mediated photodynamic therapy on human glioma stem cells. ( Fujishiro, T; Fukunaga, K; Furuse, M; Hiramatsu, R; Hosomi, R; Ikeda, N; Kajimoto, Y; Kawabata, S; Kuroiwa, T; Nakano, I; Nonoguchi, N; Omura, N; Park, Y; Wanibuchi, M; Yagi, R, 2023) |
| "The exoscope has been proposed as a valid tool in 5-aminolevulinic acid-guided resection of high-grade gliomas." | 4.31 | A Comparative Analysis with Exoscope and Optical Microscope for Intraoperative Visualization and Surgical Workflow in 5-Aminolevulinic Acid-Guided Resection of High-Grade Gliomas. ( Agostini, L; Della Pepa, GM; Doglietto, F; Mattogno, P; Menna, G; Olivi, A, 2023) |
| "Complete resection of glioblastoma via a supraorbital transciliary approach with 5-Aminolevulinic Acid use was performed without any complications, as demonstrated on postoperative MRI." | 4.31 | Supraorbital transciliary approach as primary route to fronto-basal high grade glioma resection with 5-Aminolevulinic Acid use: Technical note. ( Aboukaïs, R; Bourgeois, P; Devalckeneer, A; Lejeune, JP; Reyns, N, 2023) |
| "5-Aminolevulinic acid (5-ALA) fluorescence-guided resection of high-grade gliomas (HGG) increases the extent of resection (EOR) and progression-free survival." | 4.31 | Histology of high-grade glioma samples resected using 5-ALA fluorescent headlight and loupe combination. ( Giantini-Larsen, AM; Kharas, N; Pisapia, D; Schwartz, TH, 2023) |
| "Boron neutron capture therapy (BNCT) is a high-LET particle radiotherapy clinically tested for treating malignant gliomas." | 4.31 | 5-Aminolevulinic acid increases boronophenylalanine uptake into glioma stem cells and may sensitize malignant glioma to boron neutron capture therapy. ( Fukumura, M; Futamura, G; Hiramatsu, R; Ikeda, N; Kanemitsu, T; Kawabata, S; Kuroiwa, T; Nakano, I; Nonoguchi, N; Sampetrean, O; Saya, H; Suzuki, M; Takata, T; Takeuchi, K; Tanaka, H; Wanibuchi, M, 2023) |
| "Resection of high-grade gliomas has been considerably improved by 5-aminolevulinic acid (5-ALA)." | 4.31 | Mapping high-grade glioma immune infiltration to 5-ALA fluorescence levels: TCGA data computation, classical histology, and digital image analysis. ( Berger, W; Berghoff, AS; Erhart, F; Hainfellner, JA; Höftberger, R; Jeron, RL; Kiesel, B; Lang, A; Lontzek, B; Lötsch-Gojo, D; Mischkulnig, M; Ricken, G; Roetzer-Pejrimovsky, T; Rössler, K; Widhalm, G; Wöhrer, A, 2023) |
| "5-Aminolevulinic acid administration was associated with intraoperative hypotension in malignant glioma surgery, with increasing age and use of renin-angiotensin system inhibitors boosting the blood pressure-lowering effect of 5-aminolevulinic acid." | 4.12 | Association of 5-aminolevulinic acid with intraoperative hypotension in malignant glioma surgery. ( Fukuda, H; Fukuhara, H; Inoue, K; Ishida, T; Jobu, K; Kagimoto, N; Kawada, K; Kawanishi, Y; Masahira, N; Miyamura, M; Morisawa, S; Nakayama, T; Ogura, SI; Ohta, T; Takemura, M; Tamura, N; Ueba, T; Yamamoto, S, 2022) |
| "Use of 5-aminolevulinic acid for photodynamic malignant tumor diagnosis reportedly causes intraoperative hypotension (systolic blood pressure < 70 mmHg) during urologic surgery." | 4.12 | Association of 5-aminolevulinic acid with intraoperative hypotension in malignant glioma surgery. ( Fukuda, H; Fukuhara, H; Inoue, K; Ishida, T; Jobu, K; Kagimoto, N; Kawada, K; Kawanishi, Y; Masahira, N; Miyamura, M; Morisawa, S; Nakayama, T; Ogura, SI; Ohta, T; Takemura, M; Tamura, N; Ueba, T; Yamamoto, S, 2022) |
| "In this retrospective multicenter cohort study, we investigated intracellular nitric oxide as a candidate mediator of hypotension in response to 5-aminolevulinic acid in vitro in human umbilical vein endothelial cell cultures." | 4.12 | Association of 5-aminolevulinic acid with intraoperative hypotension in malignant glioma surgery. ( Fukuda, H; Fukuhara, H; Inoue, K; Ishida, T; Jobu, K; Kagimoto, N; Kawada, K; Kawanishi, Y; Masahira, N; Miyamura, M; Morisawa, S; Nakayama, T; Ogura, SI; Ohta, T; Takemura, M; Tamura, N; Ueba, T; Yamamoto, S, 2022) |
| "The use of 5-aminolevulinic acid (5-ALA) for intraoperative protoporphyrin IX fluorescent imaging in the resection of malignant gliomas has been demonstrated to improve tumor visualization, increase the extent of resection, and extend progression-free survival." | 4.12 | The Evolution of 5-Aminolevulinic Acid Fluorescence Visualization: Time for a Headlamp/Loupe Combination. ( Brennan, CW; Carnevale, JA; Cho, SS; De Ravin, E; Giantini-Larsen, AM; Goldberg, JL; Lee, JYK; Michael, AP; Parker, WE; Schwartz, TH; Teng, CW, 2022) |
| "Intraoperative visualization of gliomas with 5-aminolevulinic acid (5-ALA) induced fluorescence constitutes a powerful technique." | 4.12 | Analysis of corticosteroid and antiepileptic drug treatment effects on heme biosynthesis mRNA expression in lower-grade gliomas: Potential implications for 5-ALA metabolization. ( Borkovec, M; Erhart, F; Hosmann, A; Kiesel, B; Lang, A; Makolli, J; Mischkulnig, M; Roetzer, T; Rössler, K; Sperl, V; Traxler, D; Wadiura, LI; Widhalm, G, 2022) |
| "A growing body of evidence has revealed the potential utility of 5-aminolevulinic acid (5-ALA) as a surgical adjunct in selected lower-grade gliomas." | 4.12 | A Data-Driven Approach to Predicting 5-Aminolevulinic Acid-Induced Fluorescence and World Health Organization Grade in Newly Diagnosed Diffuse Gliomas. ( Jaber, M; Johnson, TD; Müther, M; Orringer, DA; Stummer, W, 2022) |
| "5-Aminolevulinic acid (ALA) is an intraoperative molecular probe approved for fluorescence-guided resection (FGR) of high-grade gliomas to achieve maximal safe tumor resection." | 4.12 | Inhibition of ABCG2 transporter by lapatinib enhances 5-aminolevulinic acid-mediated protoporphyrin IX fluorescence and photodynamic therapy response in human glioma cell lines. ( Chandratre, S; Chen, B; Howley, R; Mansi, M, 2022) |
| "5-aminolevulinic acid (5-ALA) is a proagent developed for fluorescent-guided surgery for high-grade glioma patients associated with a significant increase in resection conferring survival." | 4.12 | Utility of 5-ALA for resection of CNS tumours other than high-grade gliomas: a protocol for a systematic review. ( Gharooni, AA; Gillespie, CS; Gough, M; Jenkinson, MD; Patel, W; Plaha, P; Poon, MTC; Price, SJ; Solomou, G; Venkatesh, A; Watts, C; Wykes, V, 2022) |
| "5-aminolevulinic acid (5-ALA) - precursor of protoporphyrin IX (PpIX) - is utilized in fluorescence guided surgery (FGS) of high-grade gliomas." | 4.12 | Detection improvement of gliomas in hyperspectral imaging of protoporphyrin IX fluorescence - in vitro comparison of visual identification and machine thresholds. ( Bednarik, R; Elomaa, AP; Haneishi, H; Hauta-Kasari, M; Immonen, A; Jääskeläinen, JE; Kämäräinen, OP; Lehtonen, SJR; Paterno, JJ; Puustinen, S; Vrzakova, H, 2022) |
| " established fluorescence-guided surgery (FGS) for glioblastoma (GBM) using 5-aminolevulinic acid (5-ALA)." | 4.12 | In-Vitro Use of Verteporfin for Photodynamic Therapy in Glioblastoma. ( Geerling, G; Guthoff, R; Hänggi, D; Jeising, S; Nickel, AC; Rapp, M; Sabel, M, 2022) |
| "5-Aminolevulinic acid (5-ALA) induces fluorescence in high-grade glioma (HGG), which is used for resection." | 4.12 | Fluorescence real-time kinetics of protoporphyrin IX after 5-ALA administration in low-grade glioma. ( Black, D; Kaneko, S; Schipmann, S; Sporns, P; Stummer, W; Suero Molina, E, 2022) |
| "Fluorescence-guided resections using 5-aminolevulinic acid (5-ALA)-induced tumor porphyrins have been established as an adjunct for malignant glioma surgery based on a phase III study using specifically adapted microscopes for visualizing fluorescing protoporphyrin IX (PPIX)." | 4.02 | 5-Aminolevulinic Acid-Induced Porphyrin Contents in Various Brain Tumors: Implications Regarding Imaging Device Design and Their Validation. ( Black, D; Kaneko, S; Stummer, W; Suero Molina, E, 2021) |
| "5-Aminolevulinic Acid (5-ALA) photodiagnosis (PD) is an effective method to detect residual tumors during glioma surgery." | 4.02 | Ultrasound Modulates Fluorescence Strength and ABCG2 mRNA Response to Aminolevulinic Acid in Glioma Cells. ( Asakura, T; Higuchi, T; Morita, A; Oishi, Y; Yamaguchi, F; Yoshida, D, 2021) |
| "Although the utility 5-aminolevulinic acid (5-ALA)-mediated fluorescence-guided surgery (FGS) in meningiomas is increasingly discussed, data about the kinetics of protoporphyrin IX (PpIX) and tumor fluorescence are sparse." | 4.02 | 5-ALA kinetics in meningiomas: analysis of tumor fluorescence and PpIX metabolism in vitro and comparative analyses with high-grade gliomas. ( Brokinkel, B; Bunk, EC; Senner, V; Stummer, W; Wagner, A, 2021) |
| "This study evaluated the use of molecular imaging of fluorescent glucose analog 2-(N-(7-nitrobenz-2-oxa-1,3-diazol-4-yl)amino)-2-deoxyglucose (2-NBDG) as a discriminatory marker for intraoperative tumor border identification in a murine glioma model." | 4.02 | Molecular Imaging of Glucose Metabolism for Intraoperative Fluorescence Guidance During Glioma Surgery. ( Bardonova, L; Belykh, E; Eschbacher, JM; George, LL; Georges, JF; Healey, DR; Jubran, JH; Mehta, S; Nakaji, P; Preul, MC; Quarles, CC; Scheck, AC, 2021) |
| " In Vitro assay revealed that mutant IDH indirectly reduced the amount of exogenous 5-ALA-derived protoporphyrinogen IX in glioma cells by increasing activity of ferrochelatase and heme oxygenase 1." | 3.96 | The Correlation of Fluorescence of Protoporphyrinogen IX and Status of Isocitrate Dehydrogenase in Gliomas. ( Abe, M; Adachi, K; Hasegawa, M; Hirose, Y; Kuwahara, K; Mukherjee, J; Murayama, K; Nakae, S; Nishiyama, Y; Ohba, S; Pareira, ES; Pieper, RO; Sasaki, H; Yamada, S; Yamamoto, N, 2020) |
| "5-aminolevulinic acid (5-ALA) has been increasingly used in recent years to identify anaplastic foci in primarily suspected low-grade gliomas (LGGs)." | 3.96 | Influence of Corticosteroids and Antiepileptic Drugs on Visible 5-Aminolevulinic Acid Fluorescence in a Series of Initially Suspected Low-Grade Gliomas Including World Health Organization Grade II, III, and IV Gliomas. ( Berger, MS; Borkovec, M; Furtner, J; Hervey-Jumper, S; Hosmann, A; Kiesel, B; Mercea, PA; Mischkulnig, M; Rössler, K; Rötzer, T; Wadiura, LI; Widhalm, G, 2020) |
| "5-Aminolevulinic acid (5-ALA)-guided resection of gliomas in adults enables better delineation between tumor and normal brain, allowing improved resection and improved patients' outcome." | 3.91 | Spectroscopic measurement of 5-ALA-induced intracellular protoporphyrin IX in pediatric brain tumors. ( Brentrup, A; Kaneko, S; Köchling, M; Müther, M; Schipmann, S; Schwake, M; Stummer, W; Suero Molina, E, 2019) |
| "Approximately 20% of low-grade gliomas (LGG) display visible protoporphyrin fluorescence during surgery after 5-aminolevulinic acid (5-ALA) administration." | 3.91 | Is Visible Aminolevulinic Acid-Induced Fluorescence an Independent Biomarker for Prognosis in Histologically Confirmed (World Health Organization 2016) Low-Grade Gliomas? ( Brokinkel, B; Ewelt, C; Grauer, O; Hasselblatt, M; Jaber, M; Stummer, W; Thomas, C; Wölfer, J, 2019) |
| "In a previous study of photodynamic tumor diagnosis using 5-aminolevulinic acid (5-ALA), the authors proposed using fluorescence intensity and bright spot analyses under confocal microscopy for the precise discrimination of tumorous brain tissue (such as glioblastoma, GBM) from normal tissue." | 3.91 | Bright spot analysis for photodynamic diagnosis of brain tumors using confocal microscopy. ( Miyashita, K; Nakada, M; Tamai, S; Watanabe, T; Yoneyama, T, 2019) |
| "The aim of this study was to compare preoperative dual-time point F-fluorodeoxyglucose (FDG) uptake pattern with intraoperative 5-aminolevulinic acid (5-ALA) fluorescence in high-grade gliomas." | 3.91 | Comparison of dual-time point 18F-FDG PET/CT tumor-to-background ratio, intraoperative 5-aminolevulinic acid fluorescence scale, and Ki-67 index in high-grade glioma. ( Cho, KG; Jang, SJ; Kim, YI, 2019) |
| "5-aminolevulinic acid (5-ALA) fluorescence-guided surgery (FGS) appears to be a promising treatment for glioma." | 3.91 | Identification of PEPT2 as an important candidate molecule in 5-ALA-mediated fluorescence-guided surgery in WHO grade II/III gliomas. ( Hatanaka, KC; Hou, C; Houkin, K; Ishi, Y; Kobayashi, H; Motegi, H; Terasaka, S; Yamaguchi, S, 2019) |
| "Five-aminolevulinic acid (5-ALA) is well established for fluorescence-guided resections of malignant gliomas by eliciting the accumulation of fluorescent protoporphyrin IX (PpIX) in tumors." | 3.91 | Fluorescence-Based Measurement of Real-Time Kinetics of Protoporphyrin IX After 5-Aminolevulinic Acid Administration in Human In Situ Malignant Gliomas. ( Ewelt, C; Kaneko, S; Stummer, W; Suero Molina, E; Warneke, N, 2019) |
| "We sought to assess the impact of 5-aminolevulinic acid (5-ALA) and low-field intraoperative magnetic resonance imaging (iMRI) on the extent of resection of high-grade gliomas (HGGs)." | 3.91 | Combined Use of 5-Aminolevulinic Acid and Intraoperative Low-Field Magnetic Resonance Imaging in High-Grade Glioma Surgery. ( Bassaganyas-Vancells, C; Culebras, D; Enseñat, J; Ferrés, A; García, S; González, JJ; Hoyos, J; Reyes, L; Roldán, P; Torales, J, 2019) |
| " This study investigated the efficacy of 220-kHz TcMRgFUS combined with 5-aminolevulinic acid (5-ALA) on malignant glioma in vitro and in vivo." | 3.91 | Sonodynamic Therapy for Malignant Glioma Using 220-kHz Transcranial Magnetic Resonance Imaging-Guided Focused Ultrasound and 5-Aminolevulinic acid. ( Akahane, T; Brokman, O; Endo, S; Houkin, K; Itay, R; Kamada, H; Kato, Y; Kawase, Y; Kobayashi, H; Moriyama, K; Motegi, H; Shapira, Y; Suzuki, S; Terasaka, S; Yamaguchi, S; Yoshida, M, 2019) |
| "Surgery guided by 5-aminolevulinic acid (ALA) fluorescence has become a valuable adjunct in the resection of malignant intracranial gliomas." | 3.88 | Wavelength-specific lighted suction instrument for 5-aminolevulinic acid fluorescence-guided resection of deep-seated malignant glioma: technical note. ( Berger, MS; Han, SJ; Lau, D; Morshed, RA, 2018) |
| "5-Aminolevulinic Acid (5-ALA) induced fluorescence is useful in guiding glioma resection." | 3.88 | 5-Aminolevulinic acid fluorescence guided resection of malignant glioma: Hong Kong experience. ( Chan, DTM; Poon, WS; Yi-Pin Sonia, H, 2018) |
| "5-Aminolevulinic acid (5-ALA)-fluorescence-guided resection of malignant glioma is well established in many neuro-oncology departments." | 3.88 | 5-ALA-Induced Fluorescence in Leptomeningeal Dissemination of Spinal Malignant Glioma. ( Cornelius, JF; Gierga, K; Kamp, MA; Krause Molle, Z; Rapp, M; Sabel, M; Steiger, HJ; Turowski, B, 2018) |
| "5-Aminolevulinic acid-induced PpIX fluorescence was assessed in GL261-Luc2 cells in vitro and in vivo after implantation in mouse brains, at an invading glioma growth stage, simulating residual tumor." | 3.88 | Scanning Fiber Endoscope Improves Detection of 5-Aminolevulinic Acid-Induced Protoporphyrin IX Fluorescence at the Boundary of Infiltrative Glioma. ( Belykh, E; Byvaltsev, VA; Hu, D; Martirosyan, NL; Miller, EJ; Nakaji, P; Nelson, LY; Preul, MC; Scheck, AC; Seibel, EJ; Woolf, EC, 2018) |
| " SFE may allow accurate imaging of 5-aminolevulinic acid labeling of gliomas and other tumor types when current detection techniques have failed to provide reliable visualization." | 3.88 | Scanning Fiber Endoscope Improves Detection of 5-Aminolevulinic Acid-Induced Protoporphyrin IX Fluorescence at the Boundary of Infiltrative Glioma. ( Belykh, E; Byvaltsev, VA; Hu, D; Martirosyan, NL; Miller, EJ; Nakaji, P; Nelson, LY; Preul, MC; Scheck, AC; Seibel, EJ; Woolf, EC, 2018) |
| "Fluorescence-guided surgery with protoporphyrin IX (PpIX) as a photodiagnostic marker is gaining acceptance for resection of malignant gliomas." | 3.88 | Scanning Fiber Endoscope Improves Detection of 5-Aminolevulinic Acid-Induced Protoporphyrin IX Fluorescence at the Boundary of Infiltrative Glioma. ( Belykh, E; Byvaltsev, VA; Hu, D; Martirosyan, NL; Miller, EJ; Nakaji, P; Nelson, LY; Preul, MC; Scheck, AC; Seibel, EJ; Woolf, EC, 2018) |
| "Protoporphyrin IX (PpIX) induced by 5-aminolevulinic acid (5-ALA) is increasingly used as a fluorescent marker for fluorescence-guided resection of malignant gliomas." | 3.88 | Optical Characterization of Neurosurgical Operating Microscopes: Quantitative Fluorescence and Assessment of PpIX Photobleaching. ( Belykh, E; Bozkurt, B; Lawton, MT; Miller, EJ; Nakaji, P; Nelson, LY; Patel, AA; Preul, MC; Robinson, TR; Seibel, EJ; Spetzler, RF; Yağmurlu, K, 2018) |
| "OBJECTIVE Fluorescence guidance with 5-aminolevulinic acid (5-ALA) helps improve resections of malignant gliomas." | 3.88 | Dual-labeling with 5-aminolevulinic acid and fluorescein for fluorescence-guided resection of high-grade gliomas: technical note. ( Brokinkel, B; Ehrhardt, A; Ewelt, C; Stummer, W; Suero Molina, E; Wölfer, J, 2018) |
| "Fluorescence guided surgery (FGS) using aminolevulinic-acid (ALA) induced protoporphyrin IX (PpIX) provides intraoperative visual contrast between normal and malignant tissue during resection of high grade gliomas." | 3.85 | Hyperspectral data processing improves PpIX contrast during fluorescence guided surgery of human brain tumors. ( Bravo, JJ; Davis, SC; Kanick, SC; Olson, JD; Paulsen, KD; Roberts, DW, 2017) |
| "The clinical efficacy of 5-aminolevulinic acid (5-ALA) for fluorescence-guided surgery of malignant gliomas is evident from several studies; however, as post-operative elevations of liver enzymes have been seen, there is a potential risk of liver damage upon administration." | 3.85 | Evaluation of the risk of liver damage from the use of 5-aminolevulinic acid for intra-operative identification and resection in patients with malignant gliomas. ( Offersen, CM; Skjoeth-Rasmussen, J, 2017) |
| "5-Aminolevulinic acid (5-ALA) can accumulate protoporphyrin IX (PpIX) in tumour cell mitochondria and is well known for its utility in fluorescence-guided resection of malignant gliomas as a live molecular marker." | 3.85 | 5-Aminolevulinic acid enhances mitochondrial stress upon ionizing irradiation exposure and increases delayed production of reactive oxygen species and cell death in glioma cells. ( Kitagawa, T; Nakano, Y; Nishizawa, S; Tanaka, T; Ueta, K; Yamamoto, J, 2017) |
| "Fluorescence image guided surgery (FIGS) with 5-aminolevulinic acid for malignant gliomas improves surgical outcome." | 3.85 | Neurosurgical microscopic solid laser-based light inhibits photobleaching during fluorescence-guided brain tumor removal with 5-aminolevulinic acid. ( Fukumura, M; Furuse, M; Ikeda, N; Kajimoto, Y; Kawabata, S; Kuroiwa, T; Matsuda, F; Nonoguchi, N; Saito, K; Sato, T; Sugano, T; Takeuchi, K, 2017) |
| "Filter papers transfused with protoporphyrin IX solution and a coronally sectioned F98 glioma rat model pretreated with 50mg/kg 5-aminolevulinic acid were continuously exposed to white light." | 3.85 | Neurosurgical microscopic solid laser-based light inhibits photobleaching during fluorescence-guided brain tumor removal with 5-aminolevulinic acid. ( Fukumura, M; Furuse, M; Ikeda, N; Kajimoto, Y; Kawabata, S; Kuroiwa, T; Matsuda, F; Nonoguchi, N; Saito, K; Sato, T; Sugano, T; Takeuchi, K, 2017) |
| " 5-aminolevulinic acid (ALA) is metabolized to fluorescent protoporphyrin IX (PpIX) specifically in tumor cells, and therefore clinically used as a reagent for photodynamic diagnosis (PDD) and therapy (PDT) of cancers including gliomas." | 3.85 | Enhancement of 5-aminolevulinic acid-based fluorescence detection of side population-defined glioma stem cells by iron chelation. ( Hagiya, Y; Kokubu, Y; Murota, Y; Ogura, SI; Sugiyama, Y; Tabu, K; Taga, T; Wang, W, 2017) |
| "5-Aminolevulinic acid (5-ALA) has become an integral part in the neurosurgical treatment of malignant glioma." | 3.83 | 5-Aminolevulinic Acid Accumulation in a Cerebral Infarction Mimicking High-Grade Glioma. ( Behling, F; Bornemann, A; Hennersdorf, F; Skardelly, M; Tatagiba, M, 2016) |
| "During 5-aminolevulinic acid (ALA)-guided glioblastoma multiforme (GBM) surgery, we encountered fluorescence in ventricular walls that lacked enhancement on magnetic resonance (MR) images and were free of macroscopic invasion of tumor cells." | 3.83 | Histopathological implications of ventricle wall 5-aminolevulinic acid-induced fluorescence in the absence of tumor involvement on magnetic resonance images. ( Chang, JH; Choi, J; Kang, SG; Kim, EH; Kim, SH; Lee, JH; Moon, JH; Park, J; Roh, TH; Shim, JK; Sung, KS, 2016) |
| "This study evaluates the cost-effectiveness of 5-aminolevulinic acid (5-ALA, Gliolan®) in patients undergoing surgery for malignant glioma, in standard clinical practice conditions in Spain." | 3.81 | Cost-effectiveness of 5-aminolevulinic acid-induced fluorescence in malignant glioma surgery. ( Díez Valle, R; Galván, J; Slof, J, 2015) |
| "To evaluate the role of the neurochemical navigation with 5-aminolevulinic acid (5-ALA) during intraoperative MRI (iMRI)-guided resection of the intracranial malignant gliomas." | 3.81 | Role of neurochemical navigation with 5-aminolevulinic acid during intraoperative MRI-guided resection of intracranial malignant gliomas. ( Komori, T; Maruyama, T; Muragaki, Y; Okada, Y; Yamada, S, 2015) |
| "Previous studies have shown the individual benefits of 5-aminolevulinic acid (5-ALA) and intraoperative (i)MRI in enhancing survival for patients with high-grade glioma." | 3.81 | Outcomes after combined use of intraoperative MRI and 5-aminolevulinic acid in high-grade glioma surgery. ( Fandino, J; Fathi, AR; Landolt, H; Marbacher, S; Perrig, W; Remonda, L; Schatlo, B; Smoll, NR; Wetzel, O, 2015) |
| "Although 5-aminolevulinic acid (5-ALA)-mediated photodynamic therapy (PDT) has been demonstrated to be a novel and effective therapeutic modality for some human malignancies, its effect and mechanism on glioma are still controversial." | 3.81 | Photodynamic therapy mediated by 5-aminolevulinic acid suppresses gliomas growth by decreasing the microvessels. ( Chen, QX; Ji, BW; Liu, G; Okechi, H; Tian, DF; Wang, L; Wu, LQ; Xu, HT; Yi, W; Zhang, SQ; Zhu, XN, 2015) |
| "A 47-year-old man underwent 5-aminolevulinic acid assisted resection of high grade glioma." | 3.81 | Intra-operative acidosis during 5-aminolevulinic acid assisted glioma resection. ( Anderson, I; McKinlay, J; Naylor, T; Sivakumar, G, 2015) |
| "Fluorescence-guided surgery using 5-aminolevulinic acid (5-ALA) has become the main treatment modality in malignant gliomas." | 3.81 | Mechanism for enhanced 5-aminolevulinic acid fluorescence in isocitrate dehydrogenase 1 mutant malignant gliomas. ( Cho, HR; Choi, SH; Kim, H; Kim, JE; Kim, JY; Kim, SK; Lee, SH; Park, CK; Park, S; Park, SH; Xu, WJ, 2015) |
| "Previous studies in high-grade gliomas (HGGs) have indicated that protoporphyrin IX (PpIX) accumulates in higher concentrations in tumor tissue, and, when used to guide surgery, it has enabled improved resection leading to increased progression-free survival." | 3.81 | Quantitative fluorescence using 5-aminolevulinic acid-induced protoporphyrin IX biomarker as a surgical adjunct in low-grade glioma surgery. ( Harris, BT; Jacobs, V; Leblond, F; Paulsen, KD; Roberts, DW; Valdés, PA; Wilson, BC, 2015) |
| "To assess effectiveness of 5-aminolevulinic acid (5-ALA, Gliolan(®)) in patients treated for malignant glioma under typical daily practice conditions in Spain, using complete resection rate (CR) and progression free survival at 6 months (PFS6)." | 3.80 | Observational, retrospective study of the effectiveness of 5-aminolevulinic acid in malignant glioma surgery in Spain (The VISIONA study). ( Arza, C; Díez Valle, R; Galván, J; Romariz, C; Slof, J; Vidal, C, 2014) |
| " The study included adult patients with suspected malignant gliomas for whom the intended treatment plan included complete resection followed by radiotherapy and chemotherapy with temozolomide." | 3.80 | Observational, retrospective study of the effectiveness of 5-aminolevulinic acid in malignant glioma surgery in Spain (The VISIONA study). ( Arza, C; Díez Valle, R; Galván, J; Romariz, C; Slof, J; Vidal, C, 2014) |
| "Thirty-three patients with malignant gliomas received 5-aminolevulinic acid (20 mg/kg)." | 3.80 | 5-Aminolevulinic acid-derived tumor fluorescence: the diagnostic accuracy of visible fluorescence qualities as corroborated by spectrometry and histology and postoperative imaging. ( Bink, A; Goetz, C; Pichlmeier, U; Pietsch, T; Stepp, H; Stummer, W; Tonn, JC; Ullrich, W, 2014) |
| "Fluorescence-guided microsurgical resections of high-grade gliomas using 5-aminolevulinic acid (5-ALA) is superior to conventional microsurgery." | 3.80 | Fluorescence-guided surgery in high grade gliomas using an exoscope system. ( Belloch, JP; Cremades, A; Llácer, JL; Riesgo, PA; Rovira, V, 2014) |
| "To evaluate the use of 5-aminolevulinic acid (5-ALA) for the noninvasive detection of malignant gliomas by using in vivo magnetic resonance (MR) imaging in a mouse brain tumor model." | 3.80 | Malignant glioma: MR imaging by using 5-aminolevulinic acid in an animal model. ( Bishop, D; Cho, HR; Choi, SH; Doble, P; Han, MH; Hare, D; Kim, D; Kim, DH; Moon, WK; Park, CK, 2014) |
| "We investigated the association between the cell density and intensity of 5-aminolevulinic acid-induced fluorescence of protoporphyrin IX in 3-dimensionally cultured C6 glioma cells." | 3.80 | [Determining the tumor-cell density required for macroscopic observation of 5-ALA-induced fluorescence of protoporphyrin IX in cultured glioma cells and clinical cases]. ( Andriana, B; Hashimoto, N; Kikuta, K; Kitai, R; Miyoshi, N; Neishi, H; Takeuchi, H, 2014) |
| "Conventional imaging (intraoperative ultrasound and intraoperative magnetic resonance imaging) as well as enhanced visualization (aminolevulinic acid [ALA]-based fluorescence-guided resection) have both been used to improve the resection of malignant gliomas." | 3.80 | Navigable intraoperative ultrasound and fluorescence-guided resections are complementary in resection control of malignant gliomas: one size does not fit all. ( Moiyadi, A; Shetty, P, 2014) |
| "Five-aminolevulinic acid (Gliolan, medac, Wedel, Germany, 5-ALA) is approved for fluorescence-guided resections of adult malignant gliomas." | 3.80 | Predicting the "usefulness" of 5-ALA-derived tumor fluorescence for fluorescence-guided resections in pediatric brain tumors: a European survey. ( Artero, JM; Brentrup, A; Caird, J; Cortnum, S; Della Puppa, A; Eljamel, S; Ewald, C; González-García, L; Martin, AJ; Melada, A; Nestler, U; Peraud, A; Platania, N; Preuss, M; Rodrigues, F; Santarius, T; Schucht, P; Skjøth-Rasmussen, J; Stein, M; Steiner, HH; Stummer, W; Wiewrodt, D, 2014) |
| "Four human glioma cell lines (U87MG, U118MG, A172, and T98G) and a malignant meningioma cell line (IOMM-Lee) were incubated with gefitinib (0." | 3.79 | Gefitinib enhances the efficacy of photodynamic therapy using 5-aminolevulinic acid in malignant brain tumor cells. ( Inoue, H; Ishikawa, T; Kajimoto, Y; Kuroiwa, T; Miyatake, S; Sun, W, 2013) |
| "Only few data are available on the specific topic of 5-aminolevulinic acid (5-ALA) guided surgery of high-grade gliomas (HGG) located in eloquent areas." | 3.79 | 5-aminolevulinic acid (5-ALA) fluorescence guided surgery of high-grade gliomas in eloquent areas assisted by functional mapping. Our experience and review of the literature. ( d'Avella, E; De Pellegrin, S; Della Puppa, A; Gerardi, A; Gioffrè, G; Lombardi, G; Manara, R; Munari, M; Rossetto, M; Saladini, M; Scienza, R, 2013) |
| "(PpIX) fluorescence induced by 5-aminolevulinic acid (5-ALA), which appears in various tumors including malignant gliomas, is a good navigator for tumor resection." | 3.79 | Experimental study to understand nonspecific protoporphyrin IX fluorescence in brain tissues near tumors after 5-aminolevulinic acid administration. ( Fujishiro, T; Kajimoto, Y; Kawabata, S; Kuroiwa, T; Masubuchi, T; Miyatake, S; Nonoguchi, N, 2013) |
| "Among glioma treatment strategies, 5-aminolevulinic acid (5-ALA)-based fluorescence-guided resection (FGR) and photodynamic therapy (PDT) have been used as effective novel approaches against malignant glioma." | 3.79 | Low-dose arsenic trioxide enhances 5-aminolevulinic acid-induced PpIX accumulation and efficacy of photodynamic therapy in human glioma. ( Chen, X; Fu, C; Gao, C; Han, D; Ji, Z; Li, H; Li, X; Liu, H; Liu, Y; Liu, Z; Shi, H; Wang, C; Wang, L; Wu, J; Yang, G; Yin, F; Zhang, D; Zhao, S, 2013) |
| "These results indicate that 5-ALA fluorescence and (11) C-methionine PET image are separate index markers for cytoreduction surgery of gliomas." | 3.78 | ¹¹C-methionine uptake and intraoperative 5-aminolevulinic acid-induced fluorescence as separate index markers of cell density in glioma: a stereotactic image-histological analysis. ( Arita, H; Fujimoto, Y; Hashimoto, N; Kagawa, N; Kinoshita, M; Kishima, H; Yoshimine, T, 2012) |
| "5-Aminolevulinic acid (ALA) is a prodrug used in photodynamic therapy and fluorescence-guided resection of malignant gliomas due to its high cellular uptake in tumours." | 3.78 | Radiosensitizing effect of 5-aminolevulinic acid-induced protoporphyrin IX in glioma cells in vitro. ( Akiba, D; Kitagawa, T; Nakano, Y; Nishizawa, S; Ogura, S; Saito, T; Takahashi, M; Tanaka, T; Yamamoto, J, 2012) |
| "In recent years, 5-aminolevulinic acid (ALA)-induced protoporphyrin IX (PpIX) fluorescence guidance has been used as a surgical adjunct to improve the extent of resection of gliomas." | 3.78 | Gadolinium- and 5-aminolevulinic acid-induced protoporphyrin IX levels in human gliomas: an ex vivo quantitative study to correlate protoporphyrin IX levels and blood-brain barrier breakdown. ( Belden, CJ; Harris, BT; Kim, A; Moses, ZB; Paulsen, KD; Roberts, DW; Valdés, PA; Wilson, BC, 2012) |
| "The sonodynamically induced selective antitumor effects of 5-aminolevulinic acid (5-ALA) on a C6 glioma that was implanted in a rat brain were evaluated." | 3.78 | Sonodynamically induced antitumor effects of 5-aminolevulinic acid and fractionated ultrasound irradiation in an orthotopic rat glioma model. ( Ahn, YJ; Choi, KH; Jeong, EJ; Kim, JK; Kim, KH; Seo, SJ, 2012) |
| "To overcome these issues, we assessed the expression of ferrochelatase (FECH) gene, which encodes a key enzyme that catalyses the conversion of protoporphyrin IX (PpIX) to heme, in glioma surgical specimens and manipulated FECH in human glioma cell lines." | 3.77 | Silencing of ferrochelatase enhances 5-aminolevulinic acid-based fluorescence and photodynamic therapy efficacy. ( Endo, Y; Furuyama, N; Hamada, JI; Hayashi, Y; Nakada, M; Nambu, E; Pyko, IV; Teng, L; Zhao, SG, 2011) |
| "Photodynamic therapy (PDT) using 5-aminolevulinic acid (5-ALA) is a new therapeutic modality for malignant glioma." | 3.77 | Morphological and histological changes of glioma cells immediately after 5-aminolevulinic acid mediated photodynamic therapy. ( Iwasaki, Y; Kamoshima, Y; Kuroda, S; Terasaka, S, 2011) |
| "Fluorescence-guided resection with 5-aminolevulinic acid (5-ALA) has demonstrated its usefulness in the resection of malignant cerebral gliomas." | 3.76 | [Fluorescence-guided resection with 5-aminolevulinic acid of an intramedullary tumor]. ( Bernal-García, LM; Cabezudo-Artero, JM; Fernández-Portales, I; Giménez-Pando, J; Malca-Balcázar, JF; Mata-Gómez, J; Molina-Orozco, M; Ortega-Martínez, M; Ugarriza-Echebarrieta, LF, 2010) |
| "The photodynamic therapy using 5-aminolevulinic acid is one of the new therapeutic modalities for malignant glioma yet." | 3.74 | [Photodynamic therapy mediated with 5-aminolevulinic acid for C6 glioma spheroids]. ( Iwasaki, Y; Kamoshima, Y; Terasaka, S, 2008) |
| "The basic mechanism of cell death induced by 5-aminolevulinic acid (5-ALA)-mediated photodynamic therapy (PDT) (ALA-PDT) in glioma cells has not been fully elucidated." | 3.74 | Massive apoptotic cell death of human glioma cells via a mitochondrial pathway following 5-aminolevulinic acid-mediated photodynamic therapy. ( Inoue, H; Kajimoto, Y; Kuroiwa, T; Miyatake, S; Miyoshi, N; Ogawa, N; Otsuki, Y; Shibata, MA, 2007) |
| "Intraoperative 5-aminolevulinic acid (5-ALA)-induced fluorescence guidance for resection of malignant brain tumors was correlated with histological examination to investigate false positive findings in 42 patients with malignant glioma and six patients with metastatic brain tumor." | 3.74 | Histological examination of false positive tissue resection using 5-aminolevulinic acid-induced fluorescence guidance. ( Fujii, K; Kondo, K; Miyajima, Y; Oka, H; Sato, S; Shimizu, S; Suzuki, S; Tanizaki, Y; Utsuki, S, 2007) |
| "Five-aminolevulinic acid (5-ALA) induces the specific accumulation of photosensitising porphyrins in malignant gliomas and has been explored for photo-irradiation therapy of these tumours." | 3.73 | Oedema formation in experimental photo-irradiation therapy of brain tumours using 5-ALA. ( Ito, S; Rachinger, W; Reulen, HJ; Stepp, H; Stummer, W, 2005) |
| " The purpose of this study was to investigate the anti-tumor effects of concurrent 5-aminolevulinic acid (ALA)-mediated PDT and hyperthermia (HT) in human and rat glioma spheroids." | 3.72 | Enhanced cytotoxic effects of 5-aminolevulinic acid-mediated photodynamic therapy by concurrent hyperthermia in glioma spheroids. ( Hirschberg, H; Madsen, SJ; Sun, CH; Tromberg, BJ; Yeh, AT, 2004) |
| "The effects of photodynamic therapy (PDT) in human glioma spheroids incubated in 5-aminolevulinic acid (ALA), or ALA esters, are investigated." | 3.71 | ALA- and ALA-ester-mediated photodynamic therapy of human glioma spheroids. ( Hirschberg, H; Madsen, SJ; Sun, CH; Tromberg, BJ, 2002) |
| "Accumulation of protoporphyrin IX (PPIX) in malignant gliomas is induced by 5-aminolevulinic acid (5-ALA)." | 3.71 | Photoirradiation therapy of experimental malignant glioma with 5-aminolevulinic acid. ( Bise, K; Hundt, CS; Olzowy, B; Reulen, HJ; Stocker, S; Stummer, W, 2002) |
| "A human glioma spheroid model is used to investigate the efficacy of different light delivery schemes in 5-aminolevulinic acid (ALA)--mediated photodynamic therapy (PDT)." | 3.71 | Development of a novel indwelling balloon applicator for optimizing light delivery in photodynamic therapy. ( Hirschberg, H; Madsen, SJ; Sun, CH; Tromberg, BJ, 2001) |
| "Our observations suggest that 5-aminolevulinic acid-induced porphyrin fluorescence may label malignant gliomas safely and accurately enough to enhance the completeness of tumor removal." | 3.70 | Intraoperative detection of malignant gliomas by 5-aminolevulinic acid-induced porphyrin fluorescence. ( Fritsch, C; Goetz, AE; Goetz, C; Kiefmann, R; Reulen, HJ; Stepp, H; Stocker, S; Stummer, W; Wagner, S, 1998) |
| "Malignant gliomas accumulate fluorescing protoporphyrin IX intracellularly after exposure to 5-aminolevulinic acid, a metabolic precursor of haem." | 3.70 | Technical principles for protoporphyrin-IX-fluorescence guided microsurgical resection of malignant glioma tissue. ( Ehrhardt, A; Leonhard, M; Möller, G; Reulen, HJ; Stepp, H; Stummer, W, 1998) |
| "5-Aminolevulinic acid (5-ALA) is a natural amino acid and a precursor of heme and chlorophyll." | 2.82 | 5-Aminolevulinic Acid-Induced Protoporphyrin IX Fluorescence Imaging for Tumor Detection: Recent Advances and Challenges. ( Harada, Y; Murayama, Y; Otsuji, E; Takamatsu, T; Tanaka, H, 2022) |
| "High-grade glioma is the most common malignant primary brain tumor in adults." | 2.82 | 5-Aminolevulinic Acid Imaging of Malignant Glioma. ( Garcia, C; Hayden-Gephart, M; Jain, S; Kim, L; Li, G; Rodrigues, A; Zhang, M, 2022) |
| "5-aminolevulinic acid (5-ALA) has demonstrated its utility as an intraoperative imaging adjunct during fluorescence guided resection of malignant gliomas." | 2.82 | Utility of 5-ALA for fluorescence-guided resection of brain metastases: a systematic review. ( Ben-Shalom, N; D'Amico, RS; Khilji, H; Leskinen, S; Narayan, V; Shah, HA, 2022) |
| "The primary objective of this augmental, prospective, uncontrolled phase II multicentre trial was to assess adverse events (AE) associated with malignant glioma resection using 5-aminolevulinic (5-ALA)." | 2.76 | Favorable outcome in the elderly cohort treated by concomitant temozolomide radiochemotherapy in a multicentric phase II safety study of 5-ALA. ( Kern, BC; Krex, D; Mehdorn, HM; Nestler, U; Pichlmeier, U; Stockhammer, F; Stummer, W; Vince, GH, 2011) |
| " Clinical trials of 5-ALA RDT for HGG are needed to evaluate the optimum timing, dosing and effectiveness." | 2.72 | 5-Aminolevulinic acid radiodynamic therapy for treatment of high-grade gliomas: A systematic review. ( Michael, AP; Nordmann, NJ, 2021) |
| "Malignant gliomas are highly invasive tumors." | 2.72 | [Intraoperative Fluorescence Imaging of Brain Tumors]. ( Kuroiwa, T; Nonoguchi, N; Wanibuchi, M, 2021) |
| "5-Aminolevulinic acid is a non-fluorescent prodrug that leads to intracellular accumulation of fluorescent porphyrins in malignant gliomas-a finding that is under investigation for intraoperative identification and resection of these tumours." | 2.72 | Fluorescence-guided surgery with 5-aminolevulinic acid for resection of malignant glioma: a randomised controlled multicentre phase III trial. ( Meinel, T; Pichlmeier, U; Reulen, HJ; Stummer, W; Wiestler, OD; Zanella, F, 2006) |
| "5-Aminolevulinic acid (ALA) has been widely used as an intravital fluorescence marker in the fluorescence-guided resection of malignant gliomas." | 2.66 | 5-Aminolevulinic Acid: Pitfalls of Fluorescence-guided Resection for Malignant Gliomas and Application for Malignant Glioma Therapy. ( Kitagawa, T; Miyaoka, R; Nakano, Y; Saito, T; Suzuki, K; Takamatsu, S; Yamamoto, J, 2020) |
| "Gliomas are molecularly complex neoplasms and require a multidisciplinary approach to treatment." | 2.61 | Following the light in glioma surgery: a comparison of sodium fluorescein and 5-aminolevulinic acid as surgical adjuncts in glioma resection. ( Brown, DA; Chaichana, KL; Navarro-Bonnet, J; Quinones-Hinojosa, A; Suarez-Meade, P, 2019) |
| "Fluorescence-guided surgery for brain tumors is a contemporary adjuvant technique that allows for intraoperative delineation of diseased and normal brain thus improving maximal safe resection." | 2.61 | Following the light in glioma surgery: a comparison of sodium fluorescein and 5-aminolevulinic acid as surgical adjuncts in glioma resection. ( Brown, DA; Chaichana, KL; Navarro-Bonnet, J; Quinones-Hinojosa, A; Suarez-Meade, P, 2019) |
| "5-Aminolevulinic acid (5-ALA) is a prodrug preferentially metabolized by glioma cells that allows direct, real-time visualization of pathologic tissue through fluorescence under blue light." | 2.61 | The impact of 5-aminolevulinic acid on extent of resection in newly diagnosed high grade gliomas: a systematic review and single institutional experience. ( Haider, SA; Kalkanis, SN; Lee, IY; Lim, S, 2019) |
| "5-aminolevulinic acid (5-ALA) was approved by the FDA in June 2017 as an intra-operative optical imaging agent for patients with gliomas (suspected World Health Organization Grades III or IV on preoperative imaging) as an adjunct for the visualization of malignant tissue during surgery." | 2.61 | Established and emerging uses of 5-ALA in the brain: an overview. ( Díez Valle, R; Hadjipanayis, CG; Stummer, W, 2019) |
| "5-aminolevulinic acid (5-ALA) is a prodrug that results in the fluorescence of high-grade gliomas relative to the surrounding brain parenchyma." | 2.58 | Fluorescence-guided surgery for high-grade gliomas. ( Hadjipanayis, CG; Lakomkin, N, 2018) |
| "5-Aminolevulinic acid (5-ALA) has been approved as an intraoperative adjunct in glioma surgery in Europe, but not North America." | 2.53 | The role of 5-aminolevulinic acid in enhancing surgery for high-grade glioma, its current boundaries, and future perspectives: A systematic review. ( Bernstein, M; Hachem, LD; Klironomos, G; Mansouri, A; Mansouri, S; Vogelbaum, MA; Zadeh, G, 2016) |
| "Malignant gliomas are locally invasive tumors that offer a poor prognosis." | 2.53 | Selective 5-aminolevulinic acid-induced protoporphyrin IX fluorescence in Gliomas. ( Ma, R; Watts, C, 2016) |
| "5-aminolevulinic acid (ALA) is a precursor of haemoglobin which leads to the synthesis of porphyrins in malignant gliomas which then appears with red fluorescence under blue light." | 2.49 | [Fluorescence-guided surgery with 5-aminolevulinic acid for resection of malignant gliomas--a new treatment modality]. ( Cortnum, S; Laursen, R, 2013) |
| "Gliomas are diffuse intra-axial lesions, which can be accessed by multiple surgical corridors for a same location depending on the surgeon's preference." | 1.91 | Supraorbital transciliary approach as primary route to fronto-basal high grade glioma resection with 5-Aminolevulinic Acid use: Technical note. ( Aboukaïs, R; Bourgeois, P; Devalckeneer, A; Lejeune, JP; Reyns, N, 2023) |
| " We measured GICs-5-ALA uptake and PDT/5-ALA activity in dose-response curves and the efficacy of the treatment by measuring proliferative activity and apoptosis." | 1.91 | Preclinical Studies with Glioblastoma Brain Organoid Co-Cultures Show Efficient 5-ALA Photodynamic Therapy. ( Aldecoa, I; Bedia, C; Centellas, M; Diao, D; Ferrés, A; González Sánchez, JJ; Martínez-Soler, F; Mosteiro, A; Muñoz-Tudurí, M; Pedrosa, L; Pineda, E; Sevilla, A; Sierra, À; Stanzani, E; Tortosa, A, 2023) |
| "According to in vitro results, the low blood pressure induced by 5-aminolevulinic acid may be mediated by a nitric oxide increase in vascular endothelial cells." | 1.72 | Association of 5-aminolevulinic acid with intraoperative hypotension in malignant glioma surgery. ( Fukuda, H; Fukuhara, H; Inoue, K; Ishida, T; Jobu, K; Kagimoto, N; Kawada, K; Kawanishi, Y; Masahira, N; Miyamura, M; Morisawa, S; Nakayama, T; Ogura, SI; Ohta, T; Takemura, M; Tamura, N; Ueba, T; Yamamoto, S, 2022) |
| "5-Aminolevulinic acid (5-ALA) is an oral agent that has been increasingly adopted in fluorescence-guided resection of HGG." | 1.72 | A Novel 5-Aminolevulinic Acid-Enabled Surgical Loupe System-A Consecutive Brain Tumor Series of 11 Cases. ( Amankulor, NM; Andrews, E; Habib, A; Jaman, E; Ozpinar, A; Zhang, X; Zinn, PO, 2022) |
| "5-Aminolevulinic acid (ALA) is an intraoperative molecular probe approved for fluorescence-guided resection (FGR) of high-grade gliomas to achieve maximal safe tumor resection." | 1.72 | Inhibition of ABCG2 transporter by lapatinib enhances 5-aminolevulinic acid-mediated protoporphyrin IX fluorescence and photodynamic therapy response in human glioma cell lines. ( Chandratre, S; Chen, B; Howley, R; Mansi, M, 2022) |
| "5-aminolevulinic acid (5-ALA) is a proagent developed for fluorescent-guided surgery for high-grade glioma patients associated with a significant increase in resection conferring survival." | 1.72 | Utility of 5-ALA for resection of CNS tumours other than high-grade gliomas: a protocol for a systematic review. ( Gharooni, AA; Gillespie, CS; Gough, M; Jenkinson, MD; Patel, W; Plaha, P; Poon, MTC; Price, SJ; Solomou, G; Venkatesh, A; Watts, C; Wykes, V, 2022) |
| " No difference was found when comparing the fluorescence between primary grade I and II meningiomas after any 5-ALA dosage (p > ." | 1.62 | 5-ALA kinetics in meningiomas: analysis of tumor fluorescence and PpIX metabolism in vitro and comparative analyses with high-grade gliomas. ( Brokinkel, B; Bunk, EC; Senner, V; Stummer, W; Wagner, A, 2021) |
| "Gliomas are infiltrative brain tumors with a margin difficult to identify." | 1.56 | Machine learning-based prediction of glioma margin from 5-ALA induced PpIX fluorescence spectroscopy. ( Alston, L; Brevet, PF; Frindel, C; Guyotat, J; Leclerc, P; Mahieu-Williame, L; Meyronet, D; Montcel, B; Ray, C; Rousseau, D, 2020) |
| "5-aminolevulinic acid (5-ALA) has been increasingly used in recent years to identify anaplastic foci in primarily suspected low-grade gliomas (LGGs)." | 1.56 | Influence of Corticosteroids and Antiepileptic Drugs on Visible 5-Aminolevulinic Acid Fluorescence in a Series of Initially Suspected Low-Grade Gliomas Including World Health Organization Grade II, III, and IV Gliomas. ( Berger, MS; Borkovec, M; Furtner, J; Hervey-Jumper, S; Hosmann, A; Kiesel, B; Mercea, PA; Mischkulnig, M; Rössler, K; Rötzer, T; Wadiura, LI; Widhalm, G, 2020) |
| "High-grade gliomas are a type of malignant brain tumour." | 1.56 | 5-Aminolevulinic Acid Hydrochloride (5-ALA)-Guided Surgical Resection of High-Grade Gliomas: A Health Technology Assessment. ( , 2020) |
| "Thus, these primary brain tumors have unfavorable outcomes." | 1.51 | Comparison of different treatment schemes in 5-ALA interstitial photodynamic therapy for high-grade glioma in a preclinical model: An MRI study. ( Leroux, B; Leroy, HA; Mordon, S; Quidet, M; Reyns, N; Vermandel, M; Vignion-Dewalle, AS, 2019) |
| " Herein, we performed animal and human studies to investigate whether 5-ALA dosed glioma cells, in vitro and in vivo, release PpIX positive EVs in circulation which can be captured and analyzed." | 1.51 | Characterization of plasma-derived protoporphyrin-IX-positive extracellular vesicles following 5-ALA use in patients with malignant glioma. ( Ayinon, C; Balaj, L; Carter, BS; Charest, A; Delcuze, B; Ghiran, I; Hochberg, FH; Jones, PS; Lansbury, E; Mordecai, S; Small, JL; Tigges, J; Yekula, A, 2019) |
| "Malignant gliomas are rapidly progressive brain tumors with high mortality." | 1.51 | Characterization of plasma-derived protoporphyrin-IX-positive extracellular vesicles following 5-ALA use in patients with malignant glioma. ( Ayinon, C; Balaj, L; Carter, BS; Charest, A; Delcuze, B; Ghiran, I; Hochberg, FH; Jones, PS; Lansbury, E; Mordecai, S; Small, JL; Tigges, J; Yekula, A, 2019) |
| "High-grade gliomas are primary brain tumors that have shown increasing incidence and unfavorable outcomes." | 1.48 | MRI assessment of treatment delivery for interstitial photodynamic therapy of high-grade glioma in a preclinical model. ( Duhamel, A; Lejeune, JP; Leroux, B; Leroy, HA; Mordon, S; Reyns, N; Vermandel, M, 2018) |
| "Fluorescein has recently been reintroduced into neurosurgery, and novel microscope systems are available for visualizing this fluorochrome, which highlights all perfused tissues but has limited selectivity for tumor detection." | 1.48 | Dual-labeling with 5-aminolevulinic acid and fluorescein for fluorescence-guided resection of high-grade gliomas: technical note. ( Brokinkel, B; Ehrhardt, A; Ewelt, C; Stummer, W; Suero Molina, E; Wölfer, J, 2018) |
| "High-grade glioma is a very aggressive and infiltrative tumor in which complete resection is a chance for a better outcome." | 1.46 | 18F-Fluorocholine PET/CT, Brain MRI, and 5-Aminolevulinic Acid for the Assessment of Tumor Resection in High-Grade Glioma. ( Borrás Moreno, JM; García Vicente, AM; Jiménez Aragón, F; Jiménez Londoño, GA; Villena Martín, M, 2017) |
| "Malignant gliomas are highly invasive, difficult to treat, and account for 2% of cancer deaths worldwide." | 1.46 | ALA-PpIX mediated photodynamic therapy of malignant gliomas augmented by hypothermia. ( Chen, Y; Eubanks, JH; Fisher, CJ; Foltz, W; Lilge, L; Niu, C; Sidorova-Darmos, E, 2017) |
| " No severe adverse effects were reported." | 1.43 | Safety and Efficacy of 5-Aminolevulinic Acid for High Grade Glioma in Usual Clinical Practice: A Prospective Cohort Study. ( Arráez, MÁ; Garcia, R; González, JJ; Montané, E; Rimbau, J; Tardáguila, M; Teixidor, P; Vidal, X; Villalba, G, 2016) |
| "5-Aminolevulinic acid (5-ALA) has become an integral part in the neurosurgical treatment of malignant glioma." | 1.43 | 5-Aminolevulinic Acid Accumulation in a Cerebral Infarction Mimicking High-Grade Glioma. ( Behling, F; Bornemann, A; Hennersdorf, F; Skardelly, M; Tatagiba, M, 2016) |
| "High-grade gliomas are aggressive, incurable tumors characterized by extensive diffuse invasion of the normal brain parenchyma." | 1.42 | A pilot cost-effectiveness analysis of treatments in newly diagnosed high-grade gliomas: the example of 5-aminolevulinic Acid compared with white-light surgery. ( Alves, M; Castel-Branco, M; Esteves, S; Stummer, W, 2015) |
| "Sensitivity and specificity to detect residual tumor tissue were 75% and 100%, respectively, for iMRI and 70% and 100% for 5-ALA fluorescence." | 1.42 | Combination of Intraoperative Magnetic Resonance Imaging and Intraoperative Fluorescence to Enhance the Resection of Contrast Enhancing Gliomas. ( Duetzmann, S; Forster, MT; Franz, K; Gessler, F; Hattingen, E; Mittelbronn, M; Seifert, V; Senft, C, 2015) |
| "Also, calcitriol pretreated glioma cells exhibited increased cell death following ALA-based photodynamic therapy." | 1.40 | Calcitriol enhances 5-aminolevulinic acid-induced fluorescence and the effect of photodynamic therapy in human glioma. ( Chen, X; Fu, C; Guan, H; Li, X; Liu, H; Liu, Y; Liu, Z; Teng, L; Wang, C; Wang, L; Yang, G; Yin, F; Zhang, D; Zhang, Y; Zhao, B; Zhao, S, 2014) |
| "This finding suggests that the combined treatment of glioma cells with calcitriol plus ALA may provide an effective and selective therapeutic modality to enhance ALA-induced PpIX fluorescent quality for improving discrimination of tumor tissue and PDT efficacy." | 1.40 | Calcitriol enhances 5-aminolevulinic acid-induced fluorescence and the effect of photodynamic therapy in human glioma. ( Chen, X; Fu, C; Guan, H; Li, X; Liu, H; Liu, Y; Liu, Z; Teng, L; Wang, C; Wang, L; Yang, G; Yin, F; Zhang, D; Zhang, Y; Zhao, B; Zhao, S, 2014) |
| " The entire screening assay takes only 1 hour, and the collected PDT outcomes (cell viability) for combinatorial screening are analysed and reported as traditional dose-response curves or 3D bubble charts using custom software." | 1.40 | A high-throughput photodynamic therapy screening platform with on-chip control of multiple microenvironmental factors. ( Kim, G; Kopelman, R; Lee, YE; Lou, X; Yoon, E; Yoon, HK, 2014) |
| "As for the two biopsy cases, one was anaplastic astrocytoma and one glioblastoma multiforme." | 1.40 | Fluorescence-guided surgery in high grade gliomas using an exoscope system. ( Belloch, JP; Cremades, A; Llácer, JL; Riesgo, PA; Rovira, V, 2014) |
| "Gefitinib can inhibit ABCG2-mediated PpIX efflux from malignant brain tumor cells to increase the intracellular PpIX and thereby enhance the PDT effect." | 1.39 | Gefitinib enhances the efficacy of photodynamic therapy using 5-aminolevulinic acid in malignant brain tumor cells. ( Inoue, H; Ishikawa, T; Kajimoto, Y; Kuroiwa, T; Miyatake, S; Sun, W, 2013) |
| "Complete removal of malignant gliomas is important for the prognosis in neurosurgery treatment." | 1.39 | Automatic laser scanning ablation system for high-precision treatment of brain tumors. ( Ando, T; Fujiwara, K; Iseki, H; Kobayashi, E; Liao, H; Maruyama, T; Muragaki, Y; Sakuma, I, 2013) |
| "5-Aminolevulinic acid (ALA) is a prodrug used in photodynamic therapy and fluorescence-guided resection of malignant gliomas due to its high cellular uptake in tumours." | 1.38 | Radiosensitizing effect of 5-aminolevulinic acid-induced protoporphyrin IX in glioma cells in vitro. ( Akiba, D; Kitagawa, T; Nakano, Y; Nishizawa, S; Ogura, S; Saito, T; Takahashi, M; Tanaka, T; Yamamoto, J, 2012) |
| "Five-aminolevulinic acid (5-ALA) has been shown to accumulate in malignant tumor tissue." | 1.38 | Strong 5-aminolevulinic acid-induced fluorescence is a novel intraoperative marker for representative tissue samples in stereotactic brain tumor biopsies. ( Di Ieva, A; Furtner, J; Hainfellner, JA; Kiesel, B; Knosp, E; Marosi, C; Mert, A; Minchev, G; Prayer, D; Preusser, M; Tomanek, B; Widhalm, G; Woehrer, A; Wolfsberger, S, 2012) |
| "5-Aminolevulinic acid (5-ALA) has already been applied clinically as a photosensitizer." | 1.37 | Sonodynamic therapy with 5-aminolevulinic acid and focused ultrasound for deep-seated intracranial glioma in rat. ( Fukushima, T; Inoue, T; Kuroki, M; Ohmura, T; Sasaki, K; Shibaguchi, H; Umemura, S; Yoshizawa, S, 2011) |
| "Malignant gliomas are highly infiltrative tumours with a fatal prognosis." | 1.35 | Association of F18-fluoro-ethyl-tyrosin uptake and 5-aminolevulinic acid-induced fluorescence in gliomas. ( Fonyuy, N; Horn, P; Koch, A; Misch, M; Plotkin, M; Stockhammer, F, 2009) |
| " The proportion of dead cells increased with increases in the dosage of light." | 1.34 | Massive apoptotic cell death of human glioma cells via a mitochondrial pathway following 5-aminolevulinic acid-mediated photodynamic therapy. ( Inoue, H; Kajimoto, Y; Kuroiwa, T; Miyatake, S; Miyoshi, N; Ogawa, N; Otsuki, Y; Shibata, MA, 2007) |
| "BT (4)C orthotopic brain tumors were induced in BD-IX rats." | 1.33 | Minimally invasive photodynamic therapy (PDT) for ablation of experimental rat glioma. ( Carper, S; Hirschberg, H; Hole, P; Madsen, S; Spetalen, S; Tillung, T, 2006) |
| "High-grade gliomas are characterized by rapid proliferation, angiogenesis, and invasive growth." | 1.33 | Effects of ALA-mediated photodynamic therapy on the invasiveness of human glioma cells. ( Hirschberg, H; Krasieva, T; Madsen, SJ; Sun, CH, 2006) |
| "5-Aminolevulinic acid (ALA) has shown promising in photodynamic detection and therapy of brain tumor." | 1.32 | Protoporphyrin IX production and its photodynamic effects on glioma cells, neuroblastoma cells and normal cerebellar granule cells in vitro with 5-aminolevulinic acid and its hexylester. ( Chen, JY; Peng, Q; Ren, QG; Wu, SM; Zhou, MO, 2003) |
| "We compared resection completeness and residual tumor, determined by histopathology, after white light resection (WLR) using an operating microscope versus additional fluorescence guided resection (FGR)." | 1.32 | Increased brain tumor resection using fluorescence image guidance in a preclinical model. ( Bilbao, JM; Bogaards, A; Collens, SP; Giles, A; Lilge, LD; Lin, A; Muller, PJ; Varma, A; Wilson, BC; Yang, VX, 2004) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 6 (2.16) | 18.2507 |
| 2000's | 38 (13.67) | 29.6817 |
| 2010's | 167 (60.07) | 24.3611 |
| 2020's | 67 (24.10) | 2.80 |
| Authors | Studies |
|---|---|
| Rynda, AY | 2 |
| Olyushin, VE | 2 |
| Rostovtsev, DM | 2 |
| Zabrodskaya, YM | 2 |
| Tastanbekov, MM | 1 |
| Papayan, GV | 2 |
| Suero Molina, E | 10 |
| Kaneko, S | 6 |
| Black, D | 2 |
| Stummer, W | 47 |
| Morisawa, S | 1 |
| Jobu, K | 1 |
| Ishida, T | 1 |
| Kawada, K | 1 |
| Fukuda, H | 1 |
| Kawanishi, Y | 1 |
| Nakayama, T | 1 |
| Yamamoto, S | 1 |
| Tamura, N | 1 |
| Takemura, M | 1 |
| Kagimoto, N | 1 |
| Ohta, T | 1 |
| Masahira, N | 1 |
| Fukuhara, H | 1 |
| Ogura, SI | 2 |
| Ueba, T | 1 |
| Inoue, K | 1 |
| Miyamura, M | 1 |
| Giantini-Larsen, AM | 2 |
| Parker, WE | 1 |
| Cho, SS | 1 |
| Goldberg, JL | 1 |
| Carnevale, JA | 1 |
| Michael, AP | 3 |
| Teng, CW | 1 |
| De Ravin, E | 1 |
| Brennan, CW | 1 |
| Lee, JYK | 1 |
| Schwartz, TH | 2 |
| Mazurek, M | 1 |
| Szczepanek, D | 1 |
| Orzyłowska, A | 1 |
| Rola, R | 1 |
| Göttsche, J | 1 |
| Piffko, A | 1 |
| Pantel, TF | 1 |
| Westphal, M | 1 |
| Flitsch, J | 1 |
| Ricklefs, FL | 1 |
| Regelsberger, J | 1 |
| Dührsen, L | 1 |
| Baig Mirza, A | 1 |
| Lavrador, JP | 2 |
| Christodoulides, I | 1 |
| Boardman, TM | 1 |
| Vastani, A | 1 |
| Al Banna, Q | 1 |
| Ahmed, R | 1 |
| Norman, ICF | 1 |
| Murphy, C | 1 |
| Devi, S | 1 |
| Giamouriadis, A | 1 |
| Vergani, F | 2 |
| Gullan, R | 2 |
| Bhangoo, R | 2 |
| Ashkan, K | 2 |
| Mischkulnig, M | 5 |
| Sperl, V | 1 |
| Erhart, F | 2 |
| Kiesel, B | 8 |
| Lang, A | 3 |
| Hosmann, A | 3 |
| Roetzer, T | 1 |
| Makolli, J | 1 |
| Traxler, D | 2 |
| Borkovec, M | 3 |
| Rössler, K | 3 |
| Widhalm, G | 10 |
| Wadiura, LI | 4 |
| Naik, A | 1 |
| Smith, EJ | 1 |
| Barreau, A | 1 |
| Nyaeme, M | 1 |
| Cramer, SW | 1 |
| Najafali, D | 1 |
| Krist, DT | 1 |
| Arnold, PM | 1 |
| Hassaneen, W | 1 |
| Müther, M | 4 |
| Jaber, M | 3 |
| Johnson, TD | 1 |
| Orringer, DA | 2 |
| Zhang, X | 1 |
| Jaman, E | 1 |
| Habib, A | 1 |
| Ozpinar, A | 1 |
| Andrews, E | 1 |
| Amankulor, NM | 1 |
| Zinn, PO | 1 |
| Mansi, M | 1 |
| Howley, R | 1 |
| Chandratre, S | 1 |
| Chen, B | 1 |
| Harada, Y | 1 |
| Murayama, Y | 1 |
| Takamatsu, T | 1 |
| Otsuji, E | 1 |
| Tanaka, H | 2 |
| Solomou, G | 1 |
| Gharooni, AA | 1 |
| Patel, W | 1 |
| Gillespie, CS | 1 |
| Gough, M | 1 |
| Venkatesh, A | 1 |
| Poon, MTC | 1 |
| Wykes, V | 2 |
| Price, SJ | 1 |
| Jenkinson, MD | 3 |
| Watts, C | 4 |
| Plaha, P | 2 |
| Lehtonen, SJR | 1 |
| Vrzakova, H | 1 |
| Paterno, JJ | 1 |
| Puustinen, S | 1 |
| Bednarik, R | 1 |
| Hauta-Kasari, M | 1 |
| Haneishi, H | 1 |
| Immonen, A | 1 |
| Jääskeläinen, JE | 2 |
| Kämäräinen, OP | 1 |
| Elomaa, AP | 1 |
| Maeda, M | 1 |
| Nonaka, M | 1 |
| Naito, N | 1 |
| Ueno, K | 1 |
| Kamei, T | 1 |
| Asai, A | 1 |
| Jeising, S | 1 |
| Geerling, G | 1 |
| Guthoff, R | 1 |
| Hänggi, D | 2 |
| Sabel, M | 6 |
| Rapp, M | 4 |
| Nickel, AC | 1 |
| Ihata, T | 1 |
| Nonoguchi, N | 7 |
| Fujishiro, T | 3 |
| Omura, N | 2 |
| Kawabata, S | 6 |
| Kajimoto, Y | 8 |
| Wanibuchi, M | 5 |
| Duarte, JFS | 1 |
| Jung, GS | 1 |
| da Silva, EB | 1 |
| de Almeida Teixeira, BC | 1 |
| Cavalcanti, MS | 1 |
| Ramina, R | 1 |
| Ikeda, N | 4 |
| Furuse, M | 3 |
| Futamura, G | 2 |
| Kimura, S | 1 |
| Kameda, M | 1 |
| Yokoyama, K | 1 |
| Takami, T | 1 |
| Kawanishi, M | 1 |
| Kuroiwa, T | 9 |
| Roetzer-Pejrimovsky, T | 2 |
| Timelthaler, G | 2 |
| Millesi, M | 2 |
| Mercea, PA | 2 |
| Phillips, J | 1 |
| Hervey-Jumper, S | 2 |
| Berghoff, AS | 2 |
| Hainfellner, JA | 6 |
| Berger, MS | 5 |
| Milos, P | 1 |
| Haj-Hosseini, N | 2 |
| Hillman, J | 1 |
| Wårdell, K | 2 |
| Li, G | 1 |
| Rodrigues, A | 1 |
| Kim, L | 1 |
| Garcia, C | 1 |
| Jain, S | 1 |
| Zhang, M | 1 |
| Hayden-Gephart, M | 1 |
| McCracken, DJ | 1 |
| Schupper, AJ | 1 |
| Lakomkin, N | 2 |
| Malcolm, J | 1 |
| Painton Bray, D | 1 |
| Hadjipanayis, CG | 6 |
| Park, Y | 1 |
| Hosomi, R | 1 |
| Yagi, R | 1 |
| Hiramatsu, R | 2 |
| Fukunaga, K | 1 |
| Nakano, I | 2 |
| Shah, HA | 2 |
| Leskinen, S | 1 |
| Khilji, H | 1 |
| Narayan, V | 1 |
| Ben-Shalom, N | 1 |
| D'Amico, RS | 3 |
| Della Pepa, GM | 6 |
| Mattogno, P | 3 |
| Menna, G | 5 |
| Agostini, L | 3 |
| Olivi, A | 5 |
| Doglietto, F | 4 |
| Devalckeneer, A | 2 |
| Aboukaïs, R | 2 |
| Bourgeois, P | 2 |
| Reyns, N | 6 |
| Lejeune, JP | 4 |
| Kharas, N | 1 |
| Pisapia, D | 1 |
| Mui, OOT | 1 |
| Murray, DB | 1 |
| Walsh, B | 1 |
| Crimmins, DW | 1 |
| Caird, JD | 1 |
| Doron, O | 1 |
| Paldor, I | 1 |
| Pedrosa, L | 1 |
| Bedia, C | 1 |
| Diao, D | 1 |
| Mosteiro, A | 1 |
| Ferrés, A | 2 |
| Stanzani, E | 1 |
| Martínez-Soler, F | 1 |
| Tortosa, A | 1 |
| Pineda, E | 1 |
| Aldecoa, I | 1 |
| Centellas, M | 1 |
| Muñoz-Tudurí, M | 1 |
| Sevilla, A | 1 |
| Sierra, À | 1 |
| González Sánchez, JJ | 1 |
| Fukumura, M | 2 |
| Takeuchi, K | 2 |
| Kanemitsu, T | 1 |
| Takata, T | 1 |
| Suzuki, M | 1 |
| Sampetrean, O | 2 |
| Saya, H | 2 |
| Mehta, NH | 1 |
| Peters, DR | 1 |
| Halimi, F | 1 |
| Ozduman, K | 1 |
| Levivier, M | 1 |
| Conti, A | 1 |
| Tuleasca, C | 1 |
| Jeron, RL | 1 |
| Lontzek, B | 1 |
| Ricken, G | 1 |
| Wöhrer, A | 1 |
| Lötsch-Gojo, D | 1 |
| Berger, W | 2 |
| Höftberger, R | 1 |
| Shah, S | 1 |
| Ivey, N | 1 |
| Matur, A | 1 |
| Andaluz, N | 1 |
| Keenlyside, A | 1 |
| Marples, T | 1 |
| Gao, Z | 1 |
| Hu, H | 1 |
| Nicely, LG | 1 |
| Nogales, J | 1 |
| Li, H | 3 |
| Landgraf, L | 1 |
| Solth, A | 1 |
| Melzer, A | 1 |
| Hossain-Ibrahim, K | 1 |
| Huang, Z | 1 |
| Banerjee, S | 1 |
| Joseph, J | 1 |
| Schwake, M | 2 |
| Schipmann, S | 4 |
| Köchling, M | 2 |
| Brentrup, A | 3 |
| Watson, VL | 1 |
| Cozzens, JW | 2 |
| Bilmin, K | 2 |
| Kujawska, T | 2 |
| Grieb, P | 2 |
| Almekkawi, AK | 1 |
| El Ahmadieh, TY | 1 |
| Wu, EM | 1 |
| Abunimer, AM | 1 |
| Abi-Aad, KR | 1 |
| Aoun, SG | 1 |
| Plitt, AR | 1 |
| El Tecle, NE | 1 |
| Patel, T | 1 |
| Bendok, BR | 1 |
| Ohba, S | 2 |
| Murayama, K | 2 |
| Kuwahara, K | 1 |
| Pareira, ES | 1 |
| Nakae, S | 2 |
| Nishiyama, Y | 2 |
| Adachi, K | 2 |
| Yamada, S | 2 |
| Sasaki, H | 2 |
| Yamamoto, N | 1 |
| Abe, M | 2 |
| Mukherjee, J | 1 |
| Hasegawa, M | 2 |
| Pieper, RO | 1 |
| Hirose, Y | 2 |
| Navarro-Bonnet, J | 1 |
| Suarez-Meade, P | 1 |
| Brown, DA | 1 |
| Chaichana, KL | 1 |
| Quinones-Hinojosa, A | 1 |
| Save, AV | 1 |
| Gill, BJ | 1 |
| Canoll, P | 1 |
| Bruce, JN | 1 |
| Ius, T | 2 |
| La Rocca, G | 3 |
| Battistella, C | 1 |
| Rapisarda, A | 1 |
| Mazzucchi, E | 1 |
| Pignotti, F | 1 |
| Alexandre, A | 1 |
| Marchese, E | 2 |
| Sabatino, G | 3 |
| Kandeel, HS | 1 |
| Kalb, A | 1 |
| Reisz, Z | 1 |
| Al-Sarraj, S | 1 |
| Leclerc, P | 1 |
| Ray, C | 1 |
| Mahieu-Williame, L | 1 |
| Alston, L | 1 |
| Frindel, C | 1 |
| Brevet, PF | 1 |
| Meyronet, D | 1 |
| Guyotat, J | 3 |
| Montcel, B | 1 |
| Rousseau, D | 1 |
| Stögbauer, L | 1 |
| Jeibmann, A | 1 |
| Warneke, N | 2 |
| Rötzer, T | 1 |
| Furtner, J | 3 |
| Altieri, R | 2 |
| Barresi, V | 1 |
| Yamamoto, J | 6 |
| Kitagawa, T | 6 |
| Miyaoka, R | 1 |
| Suzuki, K | 1 |
| Takamatsu, S | 1 |
| Saito, T | 2 |
| Nakano, Y | 6 |
| Higuchi, T | 2 |
| Yamaguchi, F | 4 |
| Asakura, T | 2 |
| Yoshida, D | 1 |
| Oishi, Y | 1 |
| Morita, A | 2 |
| Warsi, NM | 1 |
| Zewude, R | 1 |
| Karmur, B | 1 |
| Pirouzmand, N | 1 |
| Hachem, L | 1 |
| Mansouri, A | 3 |
| Broekx, S | 1 |
| Weyns, F | 1 |
| De Vleeschouwer, S | 1 |
| Megyesi, JF | 1 |
| Orillac, C | 1 |
| Nordmann, NJ | 1 |
| Barbagallo, GMV | 1 |
| Certo, F | 1 |
| Di Gregorio, S | 1 |
| Maione, M | 1 |
| Garozzo, M | 1 |
| Peschillo, S | 1 |
| Bunk, EC | 1 |
| Wagner, A | 1 |
| Senner, V | 2 |
| Brokinkel, B | 4 |
| Fountain, DM | 1 |
| Bryant, A | 2 |
| Barone, DG | 3 |
| Waqar, M | 1 |
| Hart, MG | 3 |
| Bulbeck, H | 2 |
| Kernohan, A | 1 |
| Belykh, E | 3 |
| Jubran, JH | 1 |
| George, LL | 1 |
| Bardonova, L | 1 |
| Healey, DR | 1 |
| Georges, JF | 1 |
| Quarles, CC | 1 |
| Eschbacher, JM | 2 |
| Mehta, S | 1 |
| Scheck, AC | 2 |
| Nakaji, P | 3 |
| Preul, MC | 3 |
| Vogelbaum, MA | 2 |
| Kroll, D | 1 |
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| Tran, N | 1 |
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| Ford, A | 1 |
| Sparr, E | 1 |
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| Forsyth, P | 1 |
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| Stepp, H | 10 |
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| Eubanks, JH | 1 |
| Lilge, L | 1 |
| Bravo, JJ | 2 |
| Olson, JD | 2 |
| Davis, SC | 1 |
| Roberts, DW | 10 |
| Paulsen, KD | 9 |
| Kanick, SC | 2 |
| Chan, DTM | 1 |
| Yi-Pin Sonia, H | 1 |
| Poon, WS | 1 |
| Leroy, HA | 2 |
| Vermandel, M | 3 |
| Leroux, B | 2 |
| Duhamel, A | 1 |
| Mordon, S | 3 |
| Krause Molle, Z | 2 |
| Gierga, K | 1 |
| Turowski, B | 1 |
| Steiger, HJ | 6 |
| Cornelius, JF | 3 |
| Kamp, MA | 4 |
| Xie, Y | 1 |
| Thom, M | 1 |
| Ebner, M | 1 |
| Desjardins, A | 1 |
| Miserocchi, A | 1 |
| Ourselin, S | 1 |
| McEvoy, AW | 1 |
| Vercauteren, T | 1 |
| Suehiro, S | 1 |
| Ohnishi, T | 1 |
| Yamashita, D | 1 |
| Kohno, S | 1 |
| Inoue, A | 1 |
| Nishikawa, M | 1 |
| Ohue, S | 1 |
| Tanaka, J | 1 |
| Kunieda, T | 1 |
| Vale, L | 1 |
| Lawrie, TA | 2 |
| Miller, EJ | 2 |
| Hu, D | 1 |
| Martirosyan, NL | 1 |
| Woolf, EC | 1 |
| Byvaltsev, VA | 1 |
| Nelson, LY | 2 |
| Seibel, EJ | 2 |
| Ma, R | 2 |
| Osman, H | 1 |
| Georges, J | 1 |
| Elsahy, D | 1 |
| Hattab, EM | 1 |
| Yocom, S | 1 |
| Cohen-Gadol, AA | 1 |
| Li, X | 3 |
| Feng, H | 1 |
| Li, F | 1 |
| Acerbi, F | 1 |
| Restelli, F | 1 |
| de Laurentis, C | 1 |
| Falco, J | 1 |
| Cavallo, C | 1 |
| Broggi, M | 1 |
| Höhne, J | 1 |
| Schebesch, KM | 1 |
| Schiariti, M | 1 |
| Ferroli, P | 1 |
| Chohan, MO | 1 |
| Ewelt, C | 7 |
| Wölfer, J | 4 |
| Thomas, C | 1 |
| Hasselblatt, M | 1 |
| Grauer, O | 1 |
| Patel, AA | 1 |
| Bozkurt, B | 1 |
| Yağmurlu, K | 1 |
| Robinson, TR | 1 |
| Spetzler, RF | 2 |
| Lawton, MT | 1 |
| Hendricks, BK | 1 |
| Hollon, T | 1 |
| Orringer, D | 1 |
| Coburger, J | 2 |
| Wirtz, CR | 2 |
| Haider, SA | 1 |
| Lim, S | 1 |
| Kalkanis, SN | 1 |
| Lee, IY | 1 |
| Quidet, M | 1 |
| Vignion-Dewalle, AS | 1 |
| Díez Valle, R | 4 |
| Mahmoudi, K | 1 |
| Garvey, KL | 1 |
| Bouras, A | 1 |
| Cramer, G | 1 |
| Jesu Raj, JG | 1 |
| Bozec, D | 1 |
| Busch, TM | 1 |
| Yoneyama, T | 1 |
| Watanabe, T | 1 |
| Tamai, S | 1 |
| Miyashita, K | 1 |
| Nakada, M | 2 |
| Kim, YI | 1 |
| Cho, KG | 1 |
| Jang, SJ | 1 |
| Hou, C | 1 |
| Yamaguchi, S | 2 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| 3.0T High-field Intraoperative MRI Guided Extent of Resection in Cerebral Glioma Surgery: a Single Center Prospective Randomized Triple-blind Controlled Clinical Trial[NCT01479686] | Phase 3 | 321 participants (Actual) | Interventional | 2011-09-30 | Completed | ||
| 5-Aminolevulinic Acid (5-ALA) Gliolan®: Usage Increase Proposal for Neurosurgical Procedures in High-Grade Gliomas[NCT05850377] | 90 participants (Anticipated) | Observational | 2023-06-01 | Not yet recruiting | |||
| Fluorescence, Light-microscopy, Ultrasound Integrated / Intraoperative Diagnosis to MAXimise Resection[NCT05330559] | 50 participants (Anticipated) | Observational | 2022-04-08 | Not yet recruiting | |||
| Pilot Study Evaluating the Optimization of the ORBEYE Blue Light Filter During Fluorescence-Guided Resection of Gliomas[NCT04937244] | Phase 4 | 10 participants (Anticipated) | Interventional | 2021-05-13 | Recruiting | ||
| Clinical Safety Study on 5-Aminolevulinic Acid (5-ALA) in Children and Adolescents With Supratentorial Brain Tumors[NCT04738162] | Phase 2 | 80 participants (Anticipated) | Interventional | 2020-09-25 | Recruiting | ||
| Diagnostic Performance of Fluorescein as an Intraoperative Brain Tumor Biomarker: Correlation With Preoperative MR, ALA-induced PpIX Fluorescence, and Histopathology[NCT02691923] | Phase 2 | 30 participants (Anticipated) | Interventional | 2016-03-31 | Recruiting | ||
| Evaluation de l'intérêt de l'élastographie Ultrasonore et du Doppler Ultrasensible peropératoires Dans la Prise en Charge Chirurgicale Des Tumeurs cérébrales[NCT03970499] | 20 participants (Actual) | Interventional | 2019-04-15 | Completed | |||
| A Phase 1 and 2 Study of 5-aminolevulinic Acid (5-ALA) to Enhance Visualisation and Resection of Malignant Glial Tumors of the Brain[NCT01128218] | Phase 1/Phase 2 | 33 participants (Actual) | Interventional | 2011-03-31 | Completed | ||
| A Phase 1 and 2 Study of 5-aminolevulinic Acid (5-ALA) to Enhance Visualisation and Resection of Malignant Glial Tumors of the Brain[NCT00977795] | Phase 1/Phase 2 | 0 participants (Actual) | Interventional | 2009-09-30 | Withdrawn (stopped due to PI moving to Southern Illinois University to start new protocol) | ||
| Barrow 5-ALA Intraoperative Confocal Evaluation Trial[NCT01502280] | Phase 3 | 127 participants (Actual) | Interventional | 2010-11-30 | Completed | ||
| Demeclocycline Fluorescence for Intraoperative Delineation Brain Tumors[NCT02740933] | Phase 1 | 40 participants (Anticipated) | Interventional | 2016-04-30 | Not yet recruiting | ||
| Indoor Daylight Photo Dynamic Therapy (PDT) for Actinic Keratosis[NCT03805737] | 43 participants (Actual) | Interventional | 2019-11-01 | Completed | |||
| Fluorescence-guided Resection of Malignant Gliomas With 5-Aminolevulinic Acid (5-ALA) vs. Conventional Resection[NCT00241670] | Phase 3 | 415 participants (Actual) | Interventional | 1999-10-31 | Completed | ||
| A Phase 2 Study of Aminolevulinic Acid (ALA) to Enhance Visualization and Resection of Malignant Glial Tumors of the Brain[NCT01351519] | Phase 2 | 16 participants (Actual) | Interventional | 2011-05-31 | Terminated (stopped due to Limited staff available for enrollment and limited availability of drug) | ||
| Quantification of ALA-induced PpIX Fluorescence During Brain Tumor Resection[NCT02191488] | Phase 1 | 540 participants (Anticipated) | Interventional | 2014-07-31 | Active, not recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Dose escalation from 10mg/kg to 50mg/kg to determine optimal 5-ALA dose (NCT01128218)
Timeframe: 6 months
| Intervention | Dose Limiting Toxicity (Number) |
|---|---|
| Phase 1 Dose Level 1 (10mg/kg) | 0 |
| Phase 1 Dose Level 2 (20mg/kg) | 0 |
| Phase 1 Dose Level 3 (30mg/kg) | 0 |
| Phase 1 Dose Level 4 (40mg/kg) | 0 |
| Phase 1 Dose Level 5 (50mg/kg) | 0 |
"Under blue light, the neurosurgeon will take two small biopsies per patient from areas identified as obvious tumor (fluorescent) and areas in the wall of the resection cavity that were judged to be normal (but possibly edematous), non-eloquent brain (non-fluorescent). A neuropathologist will review all biopsy specimens, including those taken from the solid tumor. Pathologic confirmation of tumor type will be made by the study reference neuropathologist.~We assessed 5-ALA's resulting fluorescence for distinguishing tumor within the brain, where~True Positive: Fluorescence showing Tumor and Biopsy result Tumor False Positive: Fluorescence showing Tumor and Biopsy result No Tumor True Negative: No Fluorescence and Biopsy result No Tumor False Negative: No Fluorescence and Biopsy result Tumor~These values represent the characteristics of 5-ALA aka its ability to distinguish tumor from non-tumor." (NCT01128218)
Timeframe: Baseline
| Intervention | Biopsies (Number) | |||
|---|---|---|---|---|
| True Positives | True Negatives | False Positives | False Negatives | |
| Phase 2 Dose Level 1 (40mg/kg) | 14 | 6 | 0 | 8 |
"The neurosurgeon will take two small biopsies per patient from areas identified as obvious tumor and areas in the wall of the resection cavity that were judged to be normal, non-eloquent brain. A neuropathologist will review all biopsy specimens, including those taken from the solid tumor. Pathologic confirmation of tumor type will be made by the study reference neuropathologist.~We assessed 5-ALA's resulting fluorescence for distinguishing tumor within the brain, where~True Positive: Fluorescence showing Tumor and Biopsy result Tumor False Positive: Fluorescence showing Tumor and Biopsy result No Tumor True Negative: No Fluorescence and Biopsy result No Tumor False Negative: No Fluorescence and Biopsy result Tumor~These values represent the characteristics of 5-ALA aka its ability to distinguish tumor from non-tumor. From these parameters we determined sensitivity, specificity and the positive and negative predictive values." (NCT01128218)
Timeframe: Baseline
| Intervention | Percentage (Number) | |||
|---|---|---|---|---|
| Sensitivity | Specificity | Positive Predictive Value | Negative Predictive Value | |
| Phase 2 Dose Level 1 (40mg/kg) | 63.64 | 100 | 100 | 42.86 |
68 reviews available for aminolevulinic acid and Glial Cell Tumors
| Article | Year |
|---|---|
Analysis of Factors Affecting 5-ALA Fluorescence Intensity in Visualizing Glial Tumor Cells-Literature Review.
Topics: Aminolevulinic Acid; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette T | 2022 |
Comparison of fluorescein sodium, 5-ALA, and intraoperative MRI for resection of high-grade gliomas: A systematic review and network meta-analysis.
Topics: Aminolevulinic Acid; Brain Neoplasms; Fluorescein; Glioma; Humans; Magnetic Resonance Imaging; Netwo | 2022 |
5-Aminolevulinic Acid-Induced Protoporphyrin IX Fluorescence Imaging for Tumor Detection: Recent Advances and Challenges.
Topics: Aminolevulinic Acid; Cell Line, Tumor; Fluorescence; Glioma; Heme; Humans; Optical Imaging; Photoche | 2022 |
5-Aminolevulinic acid fluorescence in brain non-neoplastic lesions: a systematic review and case series.
Topics: Aminolevulinic Acid; Brain; Brain Neoplasms; Fluorescence; Glioma; Humans; Meningeal Neoplasms | 2022 |
5-Aminolevulinic Acid Imaging of Malignant Glioma.
Topics: Adult; Aminolevulinic Acid; Brain Neoplasms; Diagnostic Imaging; Glioma; Humans; Surgery, Computer-A | 2022 |
Turning on the light for brain tumor surgery: A 5-aminolevulinic acid story.
Topics: Aminolevulinic Acid; Brain Neoplasms; Fluorescent Dyes; Glioma; Humans; Multicenter Studies as Topic | 2022 |
Utility of 5-ALA for fluorescence-guided resection of brain metastases: a systematic review.
Topics: Aminolevulinic Acid; Brain Neoplasms; Glioma; Humans; Neuronavigation; Retrospective Studies; Surger | 2022 |
Spontaneous intracerebral haemorrhage secondary to 5-ALA-induced thrombocytopaenia in a paediatric patient: case report and literature review.
Topics: Adult; Aminolevulinic Acid; Brain Neoplasms; Cerebral Hemorrhage; Child; Child, Preschool; Glioma; H | 2023 |
Sonodynamic Therapy and Sonosensitizers for Glioma Treatment: A Systematic Qualitative Review.
Topics: Aminolevulinic Acid; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Glioma; Humans; Reactive Ox | 2023 |
Resection of the contrast-enhancing tumor in diffuse gliomas bordering eloquent areas using electrophysiology and 5-ALA fluorescence: evaluation of resection rates and neurological outcome-a systematic review and meta-analysis.
Topics: Aminolevulinic Acid; Brain Neoplasms; Electrophysiology; Fluorescence; Glioma; Humans; Quality of Li | 2023 |
Intraoperative Fluorophores: An Update on 5-Aminolevulinic Acid and Sodium Fluorescein in Resection of Tumors of the Central Nervous System and Metastatic Lesions-A Systematic Review and Meta-Analysis.
Topics: Aminolevulinic Acid; Fluorescein; Glioma; Humans; Levulinic Acids | 2023 |
Ependymal fluorescence in fluorescence-guided resection of malignant glioma: a systematic review.
Topics: Aminolevulinic Acid; Brain Neoplasms; Ependyma; Fluorescein; Fluorescence; Fluorescent Dyes; Glioma; | 2020 |
Sonodynamic Therapy for Gliomas. Perspectives and Prospects of Selective Sonosensitization of Glioma Cells.
Topics: Aminolevulinic Acid; Animals; Diagnostic Imaging; Disease Models, Animal; Glioma; Humans; Light; Pro | 2019 |
The Use of 5-Aminolevulinic Acid in Low-Grade Glioma Resection: A Systematic Review.
Topics: Aminolevulinic Acid; Brain Neoplasms; Glioma; Humans; Reproducibility of Results; Surgery, Computer- | 2020 |
Following the light in glioma surgery: a comparison of sodium fluorescein and 5-aminolevulinic acid as surgical adjuncts in glioma resection.
Topics: Aminolevulinic Acid; Brain Neoplasms; Fluorescent Dyes; Glioma; Humans; Neuronavigation; Neurosurgic | 2019 |
Fluorescein-guided resection of gliomas.
Topics: Aminolevulinic Acid; Brain Neoplasms; Fluorescent Dyes; Glioma; Humans; Neurosurgical Procedures; Su | 2019 |
5-Aminolevulinic Acid False Positives in Cerebral Neuro-Oncology: Not All That Is Fluorescent Is Tumor. A Case-Based Update and Literature Review.
Topics: Aminolevulinic Acid; Brain Neoplasms; Chemoradiotherapy, Adjuvant; Diagnostic Errors; False Positive | 2020 |
5-Aminolevulinic Acid: Pitfalls of Fluorescence-guided Resection for Malignant Gliomas and Application for Malignant Glioma Therapy.
Topics: Aminolevulinic Acid; Brain Neoplasms; Fluorescence; Glioma; Humans; Mitochondria; Photosensitizing A | 2020 |
The Cost-Effectiveness of 5-ALA in High-Grade Glioma Surgery: A Quality-Based Systematic Review.
Topics: Aminolevulinic Acid; Brain Neoplasms; Canada; Cost-Benefit Analysis; Glioma; Humans; Neoplasm Recurr | 2020 |
5-Aminolevulinic acid for recurrent malignant gliomas: A systematic review.
Topics: Aminolevulinic Acid; Brain Neoplasms; Glioma; Humans; Neoplasm Recurrence, Local; Neuronavigation; N | 2020 |
Fluorescence Guidance and Intraoperative Adjuvants to Maximize Extent of Resection.
Topics: Aminolevulinic Acid; Brain Neoplasms; Fluorescence; Glioma; Humans; Magnetic Resonance Imaging; Neur | 2021 |
5-Aminolevulinic acid radiodynamic therapy for treatment of high-grade gliomas: A systematic review.
Topics: Aminolevulinic Acid; Brain Neoplasms; Glioma; Humans; Mitochondria; Photosensitizing Agents; Radioth | 2021 |
Intraoperative imaging technology to maximise extent of resection for glioma: a network meta-analysis.
Topics: Aminolevulinic Acid; Bias; Brain Neoplasms; Glioma; Humans; Intraoperative Care; Magnetic Resonance | 2021 |
[Intraoperative Fluorescence Imaging of Brain Tumors].
Topics: Aminolevulinic Acid; Brain Neoplasms; Glioma; Humans; Japan; Multicenter Studies as Topic; Optical I | 2021 |
Fluorescence Imaging/Agents in Tumor Resection.
Topics: Aminolevulinic Acid; Blood-Brain Barrier; Brain Neoplasms; Fluorescein; Fluorescence; Fluorescent Dy | 2017 |
Maximizing safe resections: the roles of 5-aminolevulinic acid and intraoperative MR imaging in glioma surgery-review of the literature.
Topics: Aminolevulinic Acid; Brain Neoplasms; Fluorescence; Glioma; Humans; Magnetic Resonance Imaging; Neur | 2019 |
Intraoperative imaging technology to maximise extent of resection for glioma.
Topics: Aminolevulinic Acid; Brain; Brain Neoplasms; Glioma; Humans; Intraoperative Care; Magnetic Resonance | 2018 |
In Vivo Microscopy in Neurosurgical Oncology.
Topics: Aminolevulinic Acid; Brain Neoplasms; Fluorescent Dyes; Glioma; Humans; Microscopy; Neurosurgical Pr | 2018 |
5-ALA in the management of malignant glioma.
Topics: Aminolevulinic Acid; Brain Neoplasms; Glioma; Humans; Photochemotherapy; Photosensitizing Agents | 2018 |
[Progression of basic research, clinical application of photodynamic therapy and fluorescence-guided surgery in glioma treatment].
Topics: Aminolevulinic Acid; Biomedical Research; Brain Neoplasms; Chemotherapy, Adjuvant; Fluorescence; Gli | 2018 |
5-Aminolevulinic acid fluorescence guided surgery for recurrent high-grade gliomas.
Topics: Aminolevulinic Acid; Brain Neoplasms; Fluorescent Dyes; Glioma; Humans; Neoplasm Grading; Neoplasm R | 2019 |
Fluorescence-guided surgery for high-grade gliomas.
Topics: Aminolevulinic Acid; Brain Neoplasms; Clinical Trials, Phase III as Topic; Glioma; Humans; Monitorin | 2018 |
Fluorescence-guided surgery with aminolevulinic acid for low-grade gliomas.
Topics: Aminolevulinic Acid; Brain Neoplasms; Fluorescent Dyes; Glioma; Humans; Microscopy, Fluorescence; Ne | 2019 |
Surgical Adjuncts to Increase the Extent of Resection: Intraoperative MRI, Fluorescence, and Raman Histology.
Topics: Aminolevulinic Acid; Brain; Brain Neoplasms; Glioma; Humans; Magnetic Resonance Imaging; Neuronaviga | 2019 |
Fluorescence guided surgery by 5-ALA and intraoperative MRI in high grade glioma: a systematic review.
Topics: Aminolevulinic Acid; Brain Neoplasms; Fluorescent Dyes; Glioma; Humans; Magnetic Resonance Imaging, | 2019 |
The impact of 5-aminolevulinic acid on extent of resection in newly diagnosed high grade gliomas: a systematic review and single institutional experience.
Topics: Aminolevulinic Acid; Brain Neoplasms; Fluorescent Dyes; Glioma; Humans; Optical Imaging; Surgery, Co | 2019 |
Visualization technologies for 5-ALA-based fluorescence-guided surgeries.
Topics: Aminolevulinic Acid; Brain Neoplasms; Fluorescent Dyes; Glioma; Humans; Neurosurgical Procedures; Op | 2019 |
Established and emerging uses of 5-ALA in the brain: an overview.
Topics: Aminolevulinic Acid; Brain; Brain Neoplasms; Fluorescent Dyes; Glioma; Humans; Optical Imaging; Phot | 2019 |
5-ALA and FDA approval for glioma surgery.
Topics: Aminolevulinic Acid; Brain Neoplasms; Drug Approval; Fluorescent Dyes; Glioma; Humans; Optical Imagi | 2019 |
5-aminolevulinic acid photodynamic therapy for the treatment of high-grade gliomas.
Topics: Aminolevulinic Acid; Animals; Brain Neoplasms; Clinical Trials as Topic; Glioma; Humans; Photochemot | 2019 |
5-ALA fluorescence-guided surgery in pediatric brain tumors-a systematic review.
Topics: Aminolevulinic Acid; Brain Neoplasms; Child; Female; Glioma; Humans; Male; Photosensitizing Agents; | 2019 |
Optimization of high-grade glioma resection using 5-ALA fluorescence-guided surgery: A literature review and practical recommendations from the neuro-oncology club of the French society of neurosurgery.
Topics: Aminolevulinic Acid; Brain Neoplasms; Fluorescence; France; Glioma; Humans; Neurosurgical Procedures | 2019 |
5-ALA fluorescence on tumors different from malignant gliomas. Review of the literature and our experience.
Topics: Aminolevulinic Acid; Brain Neoplasms; Fluorescence; Glioma; Humans; Neuronavigation; Surgery, Comput | 2019 |
[Fluorescence-guided surgery with 5-aminolevulinic acid for resection of malignant gliomas--a new treatment modality].
Topics: Aminolevulinic Acid; Brain Neoplasms; Disease-Free Survival; Evidence-Based Medicine; Fluorescent Dy | 2013 |
Intraoperative fluorescence-guided resection of high-grade malignant gliomas using 5-aminolevulinic acid-induced porphyrins: a systematic review and meta-analysis of prospective studies.
Topics: Aminolevulinic Acid; Brain Neoplasms; Clinical Trials as Topic; Fluorescence; Glioma; Humans; Intrao | 2013 |
Image guided surgery for the resection of brain tumours.
Topics: Aminolevulinic Acid; Brain Neoplasms; Glioma; Humans; Magnetic Resonance Imaging, Interventional; Ne | 2014 |
Experimental use of photodynamic therapy in high grade gliomas: a review focused on 5-aminolevulinic acid.
Topics: Aminolevulinic Acid; Animals; Brain Neoplasms; Dose-Response Relationship, Drug; Glioma; Neoplasm Gr | 2014 |
Fluorescence in neurosurgery: Its diagnostic and therapeutic use. Review of the literature.
Topics: Aminolevulinic Acid; Brain Neoplasms; Glioma; Humans; Indocyanine Green; Optical Imaging; Photochemo | 2015 |
To what extent will 5-aminolevulinic acid change the face of malignant glioma surgery?
Topics: Aminolevulinic Acid; Brain Neoplasms; Clinical Trials, Phase III as Topic; Glioma; Humans; Neurosurg | 2015 |
What is the Surgical Benefit of Utilizing 5-Aminolevulinic Acid for Fluorescence-Guided Surgery of Malignant Gliomas?
Topics: Aminolevulinic Acid; Brain Neoplasms; Fluorescence; Glioma; Humans; Magnetic Resonance Imaging; Moni | 2015 |
[Clinical guidelines for the use of intraoperative fluorescence diagnosis in brain tumor surgery].
Topics: Aminolevulinic Acid; Brain Neoplasms; Glioma; Humans; Microscopy, Fluorescence; Monitoring, Intraope | 2015 |
The role of 5-aminolevulinic acid in brain tumor surgery: a systematic review.
Topics: Aminolevulinic Acid; Brain Neoplasms; Fluorescent Dyes; Glioma; Humans; Meningeal Neoplasms; Meningi | 2016 |
The role of 5-aminolevulinic acid in enhancing surgery for high-grade glioma, its current boundaries, and future perspectives: A systematic review.
Topics: Aminolevulinic Acid; Brain Neoplasms; Glioma; Humans; Intraoperative Care; Magnetic Resonance Imagin | 2016 |
The effectiveness and cost-effectiveness of intraoperative imaging in high-grade glioma resection; a comparative review of intraoperative ALA, fluorescein, ultrasound and MRI.
Topics: Aminolevulinic Acid; Brain Neoplasms; Contrast Media; Cost-Benefit Analysis; Fluorescein; Glioma; He | 2016 |
Selective 5-aminolevulinic acid-induced protoporphyrin IX fluorescence in Gliomas.
Topics: Aminolevulinic Acid; Brain Neoplasms; Fluorescence; Glioma; Humans; Neurons; Neurosurgical Procedure | 2016 |
Agents for fluorescence-guided glioma surgery: a systematic review of preclinical and clinical results.
Topics: Aminolevulinic Acid; Animals; Brain Neoplasms; Fluorescent Dyes; Glioma; Humans; Neurosurgical Proce | 2017 |
Fluorescence-guided resection of malignant gliomas using 5-aminolevulinic acid: practical use, risks, and pitfalls.
Topics: Aminolevulinic Acid; Brain; Brain Neoplasms; Clinical Trials as Topic; Glioma; Humans; Microscopy, F | 2008 |
Fluorescence-guided resection of malignant gliomas using 5-aminolevulinic acid: practical use, risks, and pitfalls.
Topics: Aminolevulinic Acid; Brain; Brain Neoplasms; Clinical Trials as Topic; Glioma; Humans; Microscopy, F | 2008 |
Fluorescence-guided resection of malignant gliomas using 5-aminolevulinic acid: practical use, risks, and pitfalls.
Topics: Aminolevulinic Acid; Brain; Brain Neoplasms; Clinical Trials as Topic; Glioma; Humans; Microscopy, F | 2008 |
Fluorescence-guided resection of malignant gliomas using 5-aminolevulinic acid: practical use, risks, and pitfalls.
Topics: Aminolevulinic Acid; Brain; Brain Neoplasms; Clinical Trials as Topic; Glioma; Humans; Microscopy, F | 2008 |
[Intraoperative photo-dynamic diagnosis of brain tumors].
Topics: Adult; Aged; Aminolevulinic Acid; Brain Neoplasms; Female; Fluorescence; Glioma; Humans; Intraoperat | 2009 |
The importance of surgical resection in malignant glioma.
Topics: Aminolevulinic Acid; Brain Neoplasms; Combined Modality Therapy; Glioma; Humans; Neurosurgical Proce | 2009 |
Aminolevulinic acid (ALA)-protoporphyrin IX fluorescence guided tumour resection. Part 1: Clinical, radiological and pathological studies.
Topics: Aminolevulinic Acid; Brain Neoplasms; Disease-Free Survival; Fluorescence; Glioma; Humans; Magnetic | 2012 |
Adjuncts for maximizing resection: 5-aminolevuinic acid.
Topics: Aminolevulinic Acid; Brain Neoplasms; Glioma; Humans; Intraoperative Care; Neurosurgical Procedures; | 2012 |
Aminolevulinic acid (ALA)-protoporphyrin IX fluorescence guided tumour resection. Part 2: theoretical, biochemical and practical aspects.
Topics: Aminolevulinic Acid; Brain Neoplasms; Fluorescent Dyes; Glioma; Humans; Neurosurgical Procedures; Ph | 2012 |
Emerging operative strategies in neurosurgical oncology.
Topics: Aminolevulinic Acid; Brain; Brain Mapping; Brain Neoplasms; Glioma; Humans; Microscopy, Confocal; Mo | 2012 |
New light on the brain: The role of photosensitizing agents and laser light in the management of invasive intracranial tumors.
Topics: Aminolevulinic Acid; Brain Neoplasms; Clinical Trials as Topic; Dihematoporphyrin Ether; Glioma; Hum | 2003 |
[Intraoperative photodynamic diagnosis using 5-ALA for glioma surgery].
Topics: Aminolevulinic Acid; Brain Neoplasms; Glioma; Humans; Monitoring, Intraoperative; Neoplasm, Residual | 2005 |
Repetitive photodynamic therapy of malignant brain tumors.
Topics: Aminolevulinic Acid; Animals; Brain Neoplasms; Glioma; Humans; Light; Photochemotherapy; Photosensit | 2006 |
[Intraoperative photodynamic diagnosis of human glioma using ALA induced protoporphyrin IX].
Topics: Aminolevulinic Acid; Animals; Brain Neoplasms; Glioma; Humans; Male; Mice; Middle Aged; Monitoring, | 2001 |
Various shades of red-a systematic analysis of qualitative estimation of ALA-derived fluorescence in neurosurgery.
Topics: Aminolevulinic Acid; Brain Neoplasms; Color; Evaluation Studies as Topic; Fluorescence; Fluorescent | 2018 |
15 trials available for aminolevulinic acid and Glial Cell Tumors
| Article | Year |
|---|---|
A Prospective Validation Study of the First 3D Digital Exoscope for Visualization of 5-ALA-Induced Fluorescence in High-Grade Gliomas.
Topics: Adult; Aged; Aminolevulinic Acid; Brain Neoplasms; Female; Follow-Up Studies; Glioma; Humans; Imagin | 2021 |
Randomized, Prospective Double-Blinded Study Comparing 3 Different Doses of 5-Aminolevulinic Acid for Fluorescence-Guided Resections of Malignant Gliomas.
Topics: Aminolevulinic Acid; Brain; Brain Neoplasms; Glioma; Humans; Optical Imaging; Surgery, Computer-Assi | 2017 |
A Phase 1 Dose-Escalation Study of Oral 5-Aminolevulinic Acid in Adult Patients Undergoing Resection of a Newly Diagnosed or Recurrent High-Grade Glioma.
Topics: Administration, Oral; Adult; Aged; Aminolevulinic Acid; Biopsy; Brain Neoplasms; Craniotomy; Dose-Re | 2017 |
5-Aminolevulinic acid fluorescence in high grade glioma surgery: surgical outcome, intraoperative findings, and fluorescence patterns.
Topics: Aminolevulinic Acid; Brain Neoplasms; Female; Fluorescence; Glioma; Humans; Intraoperative Care; Mal | 2014 |
A prospective Phase II clinical trial of 5-aminolevulinic acid to assess the correlation of intraoperative fluorescence intensity and degree of histologic cellularity during resection of high-grade gliomas.
Topics: Aminolevulinic Acid; Biopsy; Brain; Brain Neoplasms; Cell Count; Female; Glioblastoma; Glioma; Human | 2016 |
Five-aminolevulinic acid for fluorescence-guided resection of recurrent malignant gliomas: a phase ii study.
Topics: Adult; Aged; Aminolevulinic Acid; Brain Neoplasms; Confidence Intervals; Female; Fluorescence; Follo | 2009 |
Counterbalancing risks and gains from extended resections in malignant glioma surgery: a supplemental analysis from the randomized 5-aminolevulinic acid glioma resection study. Clinical article.
Topics: Adult; Aged; Aminolevulinic Acid; Anti-Inflammatory Agents; Brain Neoplasms; Consciousness Disorders | 2011 |
Favorable outcome in the elderly cohort treated by concomitant temozolomide radiochemotherapy in a multicentric phase II safety study of 5-ALA.
Topics: Aged; Aged, 80 and over; Aminolevulinic Acid; Antineoplastic Agents; Brain Neoplasms; Combined Modal | 2011 |
Comparison of (18)F-FET PET and 5-ALA fluorescence in cerebral gliomas.
Topics: Adult; Aged; Aminolevulinic Acid; Blood-Brain Barrier; Brain Neoplasms; Female; Gadolinium DTPA; Gli | 2011 |
Quantitative fluorescence in intracranial tumor: implications for ALA-induced PpIX as an intraoperative biomarker.
Topics: Adult; Aged; Aminolevulinic Acid; Biomarkers; Brain; Brain Neoplasms; Diagnostic Imaging; Female; Fl | 2011 |
Fluorescence and image guided resection in high grade glioma.
Topics: Adult; Aged; Aminolevulinic Acid; Brain Neoplasms; Cohort Studies; Coloring Agents; DNA-Binding Prot | 2012 |
Fluorescence-guided resections of malignant gliomas--an overview.
Topics: Aminolevulinic Acid; Biopsy; Blood-Brain Barrier; Brain; Brain Neoplasms; Cell Division; Fluorescenc | 2003 |
Fluorescence-guided surgery with 5-aminolevulinic acid for resection of malignant glioma: a randomised controlled multicentre phase III trial.
Topics: Adult; Aged; Aminolevulinic Acid; Disease-Free Survival; Fluorescent Dyes; Glioma; Humans; Middle Ag | 2006 |
Fluorescence-guided surgery with 5-aminolevulinic acid for resection of malignant glioma: a randomised controlled multicentre phase III trial.
Topics: Adult; Aged; Aminolevulinic Acid; Disease-Free Survival; Fluorescent Dyes; Glioma; Humans; Middle Ag | 2006 |
Fluorescence-guided surgery with 5-aminolevulinic acid for resection of malignant glioma: a randomised controlled multicentre phase III trial.
Topics: Adult; Aged; Aminolevulinic Acid; Disease-Free Survival; Fluorescent Dyes; Glioma; Humans; Middle Ag | 2006 |
Fluorescence-guided surgery with 5-aminolevulinic acid for resection of malignant glioma: a randomised controlled multicentre phase III trial.
Topics: Adult; Aged; Aminolevulinic Acid; Disease-Free Survival; Fluorescent Dyes; Glioma; Humans; Middle Ag | 2006 |
Fluorescence-guided surgery with 5-aminolevulinic acid for resection of malignant glioma: a randomised controlled multicentre phase III trial.
Topics: Adult; Aged; Aminolevulinic Acid; Disease-Free Survival; Fluorescent Dyes; Glioma; Humans; Middle Ag | 2006 |
Fluorescence-guided surgery with 5-aminolevulinic acid for resection of malignant glioma: a randomised controlled multicentre phase III trial.
Topics: Adult; Aged; Aminolevulinic Acid; Disease-Free Survival; Fluorescent Dyes; Glioma; Humans; Middle Ag | 2006 |
Fluorescence-guided surgery with 5-aminolevulinic acid for resection of malignant glioma: a randomised controlled multicentre phase III trial.
Topics: Adult; Aged; Aminolevulinic Acid; Disease-Free Survival; Fluorescent Dyes; Glioma; Humans; Middle Ag | 2006 |
Fluorescence-guided surgery with 5-aminolevulinic acid for resection of malignant glioma: a randomised controlled multicentre phase III trial.
Topics: Adult; Aged; Aminolevulinic Acid; Disease-Free Survival; Fluorescent Dyes; Glioma; Humans; Middle Ag | 2006 |
Fluorescence-guided surgery with 5-aminolevulinic acid for resection of malignant glioma: a randomised controlled multicentre phase III trial.
Topics: Adult; Aged; Aminolevulinic Acid; Disease-Free Survival; Fluorescent Dyes; Glioma; Humans; Middle Ag | 2006 |
Fluorescence-guided surgery with 5-aminolevulinic acid for resection of malignant glioma: a randomised controlled multicentre phase III trial.
Topics: Adult; Aged; Aminolevulinic Acid; Disease-Free Survival; Fluorescent Dyes; Glioma; Humans; Middle Ag | 2006 |
Fluorescence-guided surgery with 5-aminolevulinic acid for resection of malignant glioma: a randomised controlled multicentre phase III trial.
Topics: Adult; Aged; Aminolevulinic Acid; Disease-Free Survival; Fluorescent Dyes; Glioma; Humans; Middle Ag | 2006 |
Fluorescence-guided surgery with 5-aminolevulinic acid for resection of malignant glioma: a randomised controlled multicentre phase III trial.
Topics: Adult; Aged; Aminolevulinic Acid; Disease-Free Survival; Fluorescent Dyes; Glioma; Humans; Middle Ag | 2006 |
Fluorescence-guided surgery with 5-aminolevulinic acid for resection of malignant glioma: a randomised controlled multicentre phase III trial.
Topics: Adult; Aged; Aminolevulinic Acid; Disease-Free Survival; Fluorescent Dyes; Glioma; Humans; Middle Ag | 2006 |
Fluorescence-guided surgery with 5-aminolevulinic acid for resection of malignant glioma: a randomised controlled multicentre phase III trial.
Topics: Adult; Aged; Aminolevulinic Acid; Disease-Free Survival; Fluorescent Dyes; Glioma; Humans; Middle Ag | 2006 |
Fluorescence-guided surgery with 5-aminolevulinic acid for resection of malignant glioma: a randomised controlled multicentre phase III trial.
Topics: Adult; Aged; Aminolevulinic Acid; Disease-Free Survival; Fluorescent Dyes; Glioma; Humans; Middle Ag | 2006 |
Fluorescence-guided surgery with 5-aminolevulinic acid for resection of malignant glioma: a randomised controlled multicentre phase III trial.
Topics: Adult; Aged; Aminolevulinic Acid; Disease-Free Survival; Fluorescent Dyes; Glioma; Humans; Middle Ag | 2006 |
Fluorescence-guided surgery with 5-aminolevulinic acid for resection of malignant glioma: a randomised controlled multicentre phase III trial.
Topics: Adult; Aged; Aminolevulinic Acid; Disease-Free Survival; Fluorescent Dyes; Glioma; Humans; Middle Ag | 2006 |
Fluorescence-guided surgery with 5-aminolevulinic acid for resection of malignant glioma: a randomised controlled multicentre phase III trial.
Topics: Adult; Aged; Aminolevulinic Acid; Disease-Free Survival; Fluorescent Dyes; Glioma; Humans; Middle Ag | 2006 |
Fluorescence-guided surgery with 5-aminolevulinic acid for resection of malignant glioma: a randomised controlled multicentre phase III trial.
Topics: Adult; Aged; Aminolevulinic Acid; Disease-Free Survival; Fluorescent Dyes; Glioma; Humans; Middle Ag | 2006 |
Fluorescence-guided surgery with 5-aminolevulinic acid for resection of malignant glioma: a randomised controlled multicentre phase III trial.
Topics: Adult; Aged; Aminolevulinic Acid; Disease-Free Survival; Fluorescent Dyes; Glioma; Humans; Middle Ag | 2006 |
Fluorescence-guided surgery with 5-aminolevulinic acid for resection of malignant glioma: a randomised controlled multicentre phase III trial.
Topics: Adult; Aged; Aminolevulinic Acid; Disease-Free Survival; Fluorescent Dyes; Glioma; Humans; Middle Ag | 2006 |
Fluorescence-guided surgery with 5-aminolevulinic acid for resection of malignant glioma: a randomised controlled multicentre phase III trial.
Topics: Adult; Aged; Aminolevulinic Acid; Disease-Free Survival; Fluorescent Dyes; Glioma; Humans; Middle Ag | 2006 |
Fluorescence-guided surgery with 5-aminolevulinic acid for resection of malignant glioma: a randomised controlled multicentre phase III trial.
Topics: Adult; Aged; Aminolevulinic Acid; Disease-Free Survival; Fluorescent Dyes; Glioma; Humans; Middle Ag | 2006 |
Fluorescence-guided surgery with 5-aminolevulinic acid for resection of malignant glioma: a randomised controlled multicentre phase III trial.
Topics: Adult; Aged; Aminolevulinic Acid; Disease-Free Survival; Fluorescent Dyes; Glioma; Humans; Middle Ag | 2006 |
Fluorescence-guided surgery with 5-aminolevulinic acid for resection of malignant glioma: a randomised controlled multicentre phase III trial.
Topics: Adult; Aged; Aminolevulinic Acid; Disease-Free Survival; Fluorescent Dyes; Glioma; Humans; Middle Ag | 2006 |
ALA and malignant glioma: fluorescence-guided resection and photodynamic treatment.
Topics: Aminolevulinic Acid; Brain; Brain Neoplasms; Chemotherapy, Adjuvant; Disease-Free Survival; Fluoresc | 2007 |
Red-light excitation of protoporphyrin IX fluorescence for subsurface tumor detection.
Topics: Adult; Aged; Aminolevulinic Acid; Brain Neoplasms; Craniotomy; Female; Fluorescence; Fluorescent Dye | 2018 |
195 other studies available for aminolevulinic acid and Glial Cell Tumors
| Article | Year |
|---|---|
[Intraoperative fluorescence control with chlorin E6 in resection of glial brain tumors].
Topics: Aminolevulinic Acid; Brain Neoplasms; Chlorophyllides; Fluorescence; Glioma; Humans; Neurosurgical P | 2021 |
5-Aminolevulinic Acid-Induced Porphyrin Contents in Various Brain Tumors: Implications Regarding Imaging Device Design and Their Validation.
Topics: Aminolevulinic Acid; Brain Neoplasms; Equipment Design; Fluorescence; Glioma; Humans; Photosensitizi | 2021 |
Association of 5-aminolevulinic acid with intraoperative hypotension in malignant glioma surgery.
Topics: Aminolevulinic Acid; Cohort Studies; Endothelial Cells; Glioma; Humans; Hypotension; Photochemothera | 2022 |
The Evolution of 5-Aminolevulinic Acid Fluorescence Visualization: Time for a Headlamp/Loupe Combination.
Topics: Aminolevulinic Acid; Brain Neoplasms; Fluorescence; Glioma; Humans; Surgery, Computer-Assisted | 2022 |
[Comparative analysis of 5-ALA and chlorin E6 fluorescence-guided navigation in malignant glioma surgery].
Topics: Aminolevulinic Acid; Brain Neoplasms; Chlorophyllides; Fluorescence; Glioma; Humans; Surgery, Comput | 2022 |
Experiences with a 3D4K Digital Exoscope System (ORBEYE) in a Wide Range of Neurosurgical Procedures.
Topics: Aminolevulinic Acid; Glioma; Humans; Microsurgery; Neurosurgical Procedures | 2022 |
5-Aminolevulinic Acid-Guided Resection in Grade III Tumors-A Comparative Cohort Study.
Topics: Adult; Aminolevulinic Acid; Brain Neoplasms; Cohort Studies; Glioma; Humans; Retrospective Studies | 2022 |
Analysis of corticosteroid and antiepileptic drug treatment effects on heme biosynthesis mRNA expression in lower-grade gliomas: Potential implications for 5-ALA metabolization.
Topics: Adrenal Cortex Hormones; Aminolevulinic Acid; Anticonvulsants; Brain Neoplasms; Flavoproteins; Gliom | 2022 |
A Data-Driven Approach to Predicting 5-Aminolevulinic Acid-Induced Fluorescence and World Health Organization Grade in Newly Diagnosed Diffuse Gliomas.
Topics: Aminolevulinic Acid; Brain Neoplasms; Glioma; Humans; Isocitrate Dehydrogenase; Mutation; World Heal | 2022 |
A Novel 5-Aminolevulinic Acid-Enabled Surgical Loupe System-A Consecutive Brain Tumor Series of 11 Cases.
Topics: Aminolevulinic Acid; Brain Neoplasms; Glioma; Humans; Magnetic Resonance Imaging; Neuronavigation | 2022 |
Inhibition of ABCG2 transporter by lapatinib enhances 5-aminolevulinic acid-mediated protoporphyrin IX fluorescence and photodynamic therapy response in human glioma cell lines.
Topics: Aminolevulinic Acid; ATP Binding Cassette Transporter, Subfamily G, Member 2; Cell Line, Tumor; Ferr | 2022 |
Utility of 5-ALA for resection of CNS tumours other than high-grade gliomas: a protocol for a systematic review.
Topics: Adult; Aminolevulinic Acid; Brain Neoplasms; Glioma; Humans; Prospective Studies; Retrospective Stud | 2022 |
Detection improvement of gliomas in hyperspectral imaging of protoporphyrin IX fluorescence - in vitro comparison of visual identification and machine thresholds.
Topics: Aminolevulinic Acid; Brain Neoplasms; Glioma; Humans; Hyperspectral Imaging; Photosensitizing Agents | 2022 |
5-ALA fluorescence-guided resection of pediatric low-grade glioma using the ORBEYE 3D digital exoscope: a technical report.
Topics: Adolescent; Aminolevulinic Acid; Astrocytoma; Brain Neoplasms; Child; Female; Glioma; Humans; Surger | 2023 |
In-Vitro Use of Verteporfin for Photodynamic Therapy in Glioblastoma.
Topics: Aminolevulinic Acid; Cell Line, Tumor; Glioblastoma; Glioma; Humans; Photochemotherapy; Photosensiti | 2022 |
The effect of hypoxia on photodynamic therapy with 5-aminolevulinic acid in malignant gliomas.
Topics: Aminolevulinic Acid; Cell Line, Tumor; Glioma; Humans; Hypoxia; Oxygen; Photochemotherapy; Photosens | 2022 |
The Characteristic of Light Sources and Fluorescence in the 3-Dimensional Digital Exoscope "ORBEYE" for 5-Aminolevulinic Acid-Induced Fluorescence-Guided Surgery Compared with a Conventional Microscope.
Topics: Aminolevulinic Acid; Brain Neoplasms; Fluorescence; Glioma; Humans; Levulinic Acids; Photosensitizin | 2022 |
CD34 microvascularity in low-grade glioma: correlation with 5-aminolevulinic acid fluorescence and patient prognosis in a multicenter study at three specialized centers.
Topics: Aminolevulinic Acid; Antigens, CD34; Brain Neoplasms; Glioma; Humans; Prognosis; Retrospective Studi | 2023 |
5-ALA fluorescence in randomly selected pediatric brain tumors assessed by spectroscopy and surgical microscope.
Topics: Adolescent; Aminolevulinic Acid; Brain Neoplasms; Cerebellar Neoplasms; Child; Child, Preschool; Gli | 2023 |
Ablation efficacy of 5-aminolevulinic acid-mediated photodynamic therapy on human glioma stem cells.
Topics: Aminolevulinic Acid; Animals; Cell Line, Tumor; Glioma; Humans; Mice; Neoplasm Recurrence, Local; Ne | 2023 |
A Comparative Analysis with Exoscope and Optical Microscope for Intraoperative Visualization and Surgical Workflow in 5-Aminolevulinic Acid-Guided Resection of High-Grade Gliomas.
Topics: Aminolevulinic Acid; Brain Neoplasms; Glioma; Humans; Workflow | 2023 |
A Comparative Analysis with Exoscope and Optical Microscope for Intraoperative Visualization and Surgical Workflow in 5-Aminolevulinic Acid-Guided Resection of High-Grade Gliomas.
Topics: Aminolevulinic Acid; Brain Neoplasms; Glioma; Humans; Workflow | 2023 |
A Comparative Analysis with Exoscope and Optical Microscope for Intraoperative Visualization and Surgical Workflow in 5-Aminolevulinic Acid-Guided Resection of High-Grade Gliomas.
Topics: Aminolevulinic Acid; Brain Neoplasms; Glioma; Humans; Workflow | 2023 |
A Comparative Analysis with Exoscope and Optical Microscope for Intraoperative Visualization and Surgical Workflow in 5-Aminolevulinic Acid-Guided Resection of High-Grade Gliomas.
Topics: Aminolevulinic Acid; Brain Neoplasms; Glioma; Humans; Workflow | 2023 |
A Comparative Analysis with Exoscope and Optical Microscope for Intraoperative Visualization and Surgical Workflow in 5-Aminolevulinic Acid-Guided Resection of High-Grade Gliomas.
Topics: Aminolevulinic Acid; Brain Neoplasms; Glioma; Humans; Workflow | 2023 |
A Comparative Analysis with Exoscope and Optical Microscope for Intraoperative Visualization and Surgical Workflow in 5-Aminolevulinic Acid-Guided Resection of High-Grade Gliomas.
Topics: Aminolevulinic Acid; Brain Neoplasms; Glioma; Humans; Workflow | 2023 |
A Comparative Analysis with Exoscope and Optical Microscope for Intraoperative Visualization and Surgical Workflow in 5-Aminolevulinic Acid-Guided Resection of High-Grade Gliomas.
Topics: Aminolevulinic Acid; Brain Neoplasms; Glioma; Humans; Workflow | 2023 |
A Comparative Analysis with Exoscope and Optical Microscope for Intraoperative Visualization and Surgical Workflow in 5-Aminolevulinic Acid-Guided Resection of High-Grade Gliomas.
Topics: Aminolevulinic Acid; Brain Neoplasms; Glioma; Humans; Workflow | 2023 |
A Comparative Analysis with Exoscope and Optical Microscope for Intraoperative Visualization and Surgical Workflow in 5-Aminolevulinic Acid-Guided Resection of High-Grade Gliomas.
Topics: Aminolevulinic Acid; Brain Neoplasms; Glioma; Humans; Workflow | 2023 |
Supraorbital transciliary approach as primary route to fronto-basal high grade glioma resection with 5-Aminolevulinic Acid use: Technical note.
Topics: Aminolevulinic Acid; Brain Neoplasms; Glioblastoma; Glioma; Humans; Neoplasm Recurrence, Local; Temo | 2023 |
Supraorbital transciliary approach as primary route to fronto-basal high grade glioma resection with 5-Aminolevulinic Acid use: Technical note.
Topics: Aminolevulinic Acid; Brain Neoplasms; Glioblastoma; Glioma; Humans; Neoplasm Recurrence, Local; Temo | 2023 |
Supraorbital transciliary approach as primary route to fronto-basal high grade glioma resection with 5-Aminolevulinic Acid use: Technical note.
Topics: Aminolevulinic Acid; Brain Neoplasms; Glioblastoma; Glioma; Humans; Neoplasm Recurrence, Local; Temo | 2023 |
Supraorbital transciliary approach as primary route to fronto-basal high grade glioma resection with 5-Aminolevulinic Acid use: Technical note.
Topics: Aminolevulinic Acid; Brain Neoplasms; Glioblastoma; Glioma; Humans; Neoplasm Recurrence, Local; Temo | 2023 |
Histology of high-grade glioma samples resected using 5-ALA fluorescent headlight and loupe combination.
Topics: Aminolevulinic Acid; Brain Neoplasms; Coloring Agents; Glioblastoma; Glioma; Humans; Surgery, Comput | 2023 |
[FALSE POSITIVE 5-ALA INDUCED FLUORESCENCE OF HEMATOLOGICAL MALIGNANCIES, BENIGN TUMORS, INFECTIOUS AND INFLAMMATORY PATHOLOGIES PRESENTED AS BRAIN LESIONS - A CASE SERIES].
Topics: Aminolevulinic Acid; Brain Neoplasms; Fluorescence; Glioma; Hematologic Neoplasms; Humans | 2023 |
Preclinical Studies with Glioblastoma Brain Organoid Co-Cultures Show Efficient 5-ALA Photodynamic Therapy.
Topics: Aminolevulinic Acid; Brain; Brain Neoplasms; Cell Line, Tumor; Coculture Techniques; Glioblastoma; G | 2023 |
5-Aminolevulinic acid increases boronophenylalanine uptake into glioma stem cells and may sensitize malignant glioma to boron neutron capture therapy.
Topics: Aminolevulinic Acid; Animals; Boron; Boron Compounds; Boron Neutron Capture Therapy; Brain Neoplasms | 2023 |
Mapping high-grade glioma immune infiltration to 5-ALA fluorescence levels: TCGA data computation, classical histology, and digital image analysis.
Topics: Aminolevulinic Acid; Biomarkers; Brain Neoplasms; Diagnostic Imaging; Fluorescence; Glioma; Humans | 2023 |
Comparison of minimal detectable protoporphyrin IX concentrations with a loupe device and conventional 5-ALA fluorescence microscopy: an experimental study.
Topics: Aminolevulinic Acid; Brain Neoplasms; Fluorescence; Glioma; Humans; Microscopy, Fluorescence; Photos | 2023 |
Development and optimisation of in vitro sonodynamic therapy for glioblastoma.
Topics: Aminolevulinic Acid; Apoptosis; Cell Line, Tumor; Glioblastoma; Glioma; Humans; Reactive Oxygen Spec | 2023 |
Spectroscopic measurement of 5-ALA-induced intracellular protoporphyrin IX in pediatric brain tumors.
Topics: Adolescent; Aminolevulinic Acid; Brain; Brain Neoplasms; Child; Child, Preschool; Female; Fluorescen | 2019 |
Use of 5-Aminolevulinic Acid for Confirmation of Lesional Biopsy Sample in Presumed High-Grade Glioma.
Topics: Aged; Aminolevulinic Acid; Biopsy; Brain Neoplasms; Fluorescence; Glioma; Humans; Male; Neoplasm Gra | 2019 |
The Correlation of Fluorescence of Protoporphyrinogen IX and Status of Isocitrate Dehydrogenase in Gliomas.
Topics: Adult; Aged; Aminolevulinic Acid; Brain Neoplasms; Female; Glioma; Humans; Intraoperative Period; Is | 2020 |
"Dark corridors" in 5-ALA resection of high-grade gliomas: combining fluorescence-guided surgery and contrast-enhanced ultrasonography to better explore the surgical field.
Topics: Adult; Aged; Aged, 80 and over; Aminolevulinic Acid; Brain Neoplasms; Female; Fluorescence; Glioma; | 2019 |
5-ALA fluorescence in a WHO grade I papillary glioneuronal tumour: a case report.
Topics: Aminolevulinic Acid; Brain Neoplasms; Female; Fluorescence; Glioma; Humans; Magnetic Resonance Imagi | 2020 |
Machine learning-based prediction of glioma margin from 5-ALA induced PpIX fluorescence spectroscopy.
Topics: Aminolevulinic Acid; Biomarkers, Tumor; Brain Neoplasms; Cell Line, Tumor; Cluster Analysis; Compute | 2020 |
Validating a new generation filter system for visualizing 5-ALA-induced PpIX fluorescence in malignant glioma surgery: a proof of principle study.
Topics: Adult; Aged; Aged, 80 and over; Aminolevulinic Acid; Biopsy; Brain Neoplasms; Cell Count; Female; Fl | 2020 |
Influence of Corticosteroids and Antiepileptic Drugs on Visible 5-Aminolevulinic Acid Fluorescence in a Series of Initially Suspected Low-Grade Gliomas Including World Health Organization Grade II, III, and IV Gliomas.
Topics: Adrenal Cortex Hormones; Adult; Aged; Aminolevulinic Acid; Anticonvulsants; Brain Neoplasms; Female; | 2020 |
5-Aminolevulinic Acid Hydrochloride (5-ALA)-Guided Surgical Resection of High-Grade Gliomas: A Health Technology Assessment.
Topics: Aminolevulinic Acid; Brain Neoplasms; Cost-Benefit Analysis; Glioma; Humans; Neoplasm Grading; Optic | 2020 |
Ultrasound Modulates Fluorescence Strength and ABCG2 mRNA Response to Aminolevulinic Acid in Glioma Cells.
Topics: Aminolevulinic Acid; ATP Binding Cassette Transporter, Subfamily G, Member 2; Cell Line, Tumor; Fluo | 2021 |
Canada, Neurosurgery, and 5-Aminolevulinic Acid (5-ALA): The Long and Winding Road.
Topics: Aminolevulinic Acid; Brain Neoplasms; Canada; Glioma; Humans; Neurosurgery; Neurosurgical Procedures | 2020 |
Recurrent high-grade glioma surgery: a multimodal intraoperative protocol to safely increase extent of tumor resection and analysis of its impact on patient outcome.
Topics: Aminolevulinic Acid; Brain Neoplasms; Glioma; Humans; Magnetic Resonance Imaging; Neoplasm Recurrenc | 2021 |
5-ALA kinetics in meningiomas: analysis of tumor fluorescence and PpIX metabolism in vitro and comparative analyses with high-grade gliomas.
Topics: Aminolevulinic Acid; Cell Line, Tumor; Glioma; Humans; Kinetics; Meningeal Neoplasms; Meningioma; Op | 2021 |
Molecular Imaging of Glucose Metabolism for Intraoperative Fluorescence Guidance During Glioma Surgery.
Topics: 4-Chloro-7-nitrobenzofurazan; Aminolevulinic Acid; Animals; Apoptosis; Brain; Brain Neoplasms; Cell | 2021 |
Fluorescence real-time kinetics of protoporphyrin IX after 5-ALA administration in low-grade glioma.
Topics: Adult; Aminolevulinic Acid; Brain Neoplasms; Chromosome Deletion; Female; Fluorescence; Glioma; Huma | 2022 |
Elevated cellular PpIX potentiates sonodynamic therapy in a mouse glioma stem cell-bearing glioma model by downregulating the Akt/NF-κB/MDR1 pathway.
Topics: Aminolevulinic Acid; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cell Line, Tu | 2021 |
18F-Fluorocholine PET/CT, Brain MRI, and 5-Aminolevulinic Acid for the Assessment of Tumor Resection in High-Grade Glioma.
Topics: Aminolevulinic Acid; Brain; Brain Neoplasms; Choline; Glioma; Humans; Magnetic Resonance Imaging; Ma | 2017 |
Optical-sectioning microscopy of protoporphyrin IX fluorescence in human gliomas: standardization and quantitative comparison with histology.
Topics: Algorithms; Aminolevulinic Acid; Brain Neoplasms; Diagnostic Imaging; Disease-Free Survival; Glioma; | 2017 |
Is fluorescence-guided surgery with 5-ala in eloquent areas for malignant gliomas a reasonable and useful technique?
Topics: Adult; Aged; Aminolevulinic Acid; Brain Mapping; Brain Neoplasms; Disease-Free Survival; Female; Flu | 2017 |
Wavelength-specific lighted suction instrument for 5-aminolevulinic acid fluorescence-guided resection of deep-seated malignant glioma: technical note.
Topics: Aged; Aminolevulinic Acid; Brain Neoplasms; Female; Fiber Optic Technology; Fluorescent Dyes; Glioma | 2018 |
ALA-PpIX mediated photodynamic therapy of malignant gliomas augmented by hypothermia.
Topics: Aminolevulinic Acid; Animals; Animals, Newborn; Astrocytes; Brain; Brain Neoplasms; Cell Line, Tumor | 2017 |
Hyperspectral data processing improves PpIX contrast during fluorescence guided surgery of human brain tumors.
Topics: Algorithms; Aminolevulinic Acid; Brain Neoplasms; Electronic Data Processing; Glioma; Humans; Neuros | 2017 |
5-Aminolevulinic acid fluorescence guided resection of malignant glioma: Hong Kong experience.
Topics: Adult; Aminolevulinic Acid; Asian People; Brain Neoplasms; Contrast Media; Female; Glioma; Hong Kong | 2018 |
MRI assessment of treatment delivery for interstitial photodynamic therapy of high-grade glioma in a preclinical model.
Topics: Aminolevulinic Acid; Animals; Brain Neoplasms; Disease Models, Animal; Glioma; Magnetic Resonance Im | 2018 |
5-ALA-Induced Fluorescence in Leptomeningeal Dissemination of Spinal Malignant Glioma.
Topics: Adult; Aminolevulinic Acid; Female; Glial Fibrillary Acidic Protein; Glioma; Humans; Magnetic Resona | 2018 |
Wide-field spectrally resolved quantitative fluorescence imaging system: toward neurosurgical guidance in glioma resection.
Topics: Aminolevulinic Acid; Glioma; Humans; Neurosurgery; Optical Imaging; Photosensitizing Agents; Protopo | 2017 |
Enhancement of antitumor activity by using 5-ALA-mediated sonodynamic therapy to induce apoptosis in malignant gliomas: significance of high-intensity focused ultrasound on 5-ALA-SDT in a mouse glioma model.
Topics: Aminolevulinic Acid; Animals; Apoptosis; Brain Neoplasms; Cell Proliferation; Disease Models, Animal | 2018 |
Scanning Fiber Endoscope Improves Detection of 5-Aminolevulinic Acid-Induced Protoporphyrin IX Fluorescence at the Boundary of Infiltrative Glioma.
Topics: Administration, Oral; Aminolevulinic Acid; Animals; Biotransformation; Brain Neoplasms; Cell Line, T | 2018 |
Reaching the Edge of Diffuse Gliomas: Are We There Yet?
Topics: Aminolevulinic Acid; Brain Neoplasms; Fluorescence; Glioma; Photosensitizing Agents | 2018 |
Fluorescent tracers in neurosurgical procedures: a European survey.
Topics: Adult; Aminolevulinic Acid; Brain Neoplasms; Fluorescent Dyes; Glioma; Humans; Neurosurgical Procedu | 2021 |
Is Visible Aminolevulinic Acid-Induced Fluorescence an Independent Biomarker for Prognosis in Histologically Confirmed (World Health Organization 2016) Low-Grade Gliomas?
Topics: Adult; Aminolevulinic Acid; Biomarkers; Biopsy; Brain Neoplasms; Female; Fluorescence; Glioma; Human | 2019 |
Optical Characterization of Neurosurgical Operating Microscopes: Quantitative Fluorescence and Assessment of PpIX Photobleaching.
Topics: Aminolevulinic Acid; Animals; Brain Neoplasms; Equipment Design; Female; Fluorescence; Fluorescent D | 2018 |
Comparison of different treatment schemes in 5-ALA interstitial photodynamic therapy for high-grade glioma in a preclinical model: An MRI study.
Topics: Aminolevulinic Acid; Animals; Biomarkers, Tumor; Brain Neoplasms; Cell Line, Tumor; Glioma; Humans; | 2019 |
Bright spot analysis for photodynamic diagnosis of brain tumors using confocal microscopy.
Topics: Aminolevulinic Acid; Brain Neoplasms; Female; Glioblastoma; Glioma; Humans; Male; Microscopy, Confoc | 2019 |
Comparison of dual-time point 18F-FDG PET/CT tumor-to-background ratio, intraoperative 5-aminolevulinic acid fluorescence scale, and Ki-67 index in high-grade glioma.
Topics: Aged; Aged, 80 and over; Aminolevulinic Acid; Brain Neoplasms; Cell Proliferation; Female; Fluoresce | 2019 |
Identification of PEPT2 as an important candidate molecule in 5-ALA-mediated fluorescence-guided surgery in WHO grade II/III gliomas.
Topics: Aminolevulinic Acid; Biomarkers, Tumor; Brain Neoplasms; Fluorescence; Follow-Up Studies; Glioma; Hu | 2019 |
5-Aminolevulinic Acid Suppresses Prostaglandin E2 Production by Murine Macrophages and Enhances Macrophage Cytotoxicity Against Glioma.
Topics: Aminolevulinic Acid; Animals; Cell Line, Tumor; Cells, Cultured; Coculture Techniques; Dinoprostone; | 2019 |
Fluorescence-Based Measurement of Real-Time Kinetics of Protoporphyrin IX After 5-Aminolevulinic Acid Administration in Human In Situ Malignant Gliomas.
Topics: Adult; Aged; Aged, 80 and over; Aminolevulinic Acid; Brain Neoplasms; Female; Glioma; Humans; Kineti | 2019 |
Ex-vivo analysis of quantitative 5-ALA fluorescence intensity in diffusely infiltrating gliomas using a handheld spectroscopic probe: Correlation with histopathology, proliferation and microvascular density.
Topics: Adult; Aged; Aged, 80 and over; Aminolevulinic Acid; Female; Glioma; Humans; Male; Middle Aged; Neop | 2019 |
Optimizing 5-ALA Induced Fluorescence Visualization: Comment Regarding Recent Article on Fluorescence-Based Real-Time Kinetics Protoporphyrin-IX Measurements Article in Neurosurgery.
Topics: Aminolevulinic Acid; Fluorescence; Glioma; Humans; Kinetics; Neurosurgery; Photosensitizing Agents; | 2019 |
High-Definition 3-Dimensional Exoscope for 5-ALA Glioma Surgery: 3-Dimensional Operative Video.
Topics: Aminolevulinic Acid; Brain Neoplasms; Glioma; Humans; Japan; Male; Middle Aged; Neoplasm Recurrence, | 2020 |
Combined Use of 5-Aminolevulinic Acid and Intraoperative Low-Field Magnetic Resonance Imaging in High-Grade Glioma Surgery.
Topics: Adult; Aged; Aged, 80 and over; Aminolevulinic Acid; Brain Neoplasms; Combined Modality Therapy; Fol | 2019 |
"Enhancing Vision" in High Grade Glioma Surgery: A Feasible Integrated 5-ALA + CEUS Protocol to Improve Radicality.
Topics: Aminolevulinic Acid; Brain Neoplasms; Contrast Media; Glioma; Humans; Neuroimaging; Surgery, Compute | 2019 |
Is the Intensity of 5-Aminolevulinic Acid-Derived Fluorescence Related to the Light Source?
Topics: Aminolevulinic Acid; Brain Neoplasms; Fluorescence; Glioma; Humans; Light; Neurosurgical Procedures; | 2019 |
Supraorbital trans-eyebrow craniotomy and fluorescence-guided resection of fronto-basal high grade gliomas.
Topics: Aged; Aminolevulinic Acid; Basal Ganglia; Brain Neoplasms; Chemoradiotherapy, Adjuvant; Craniotomy; | 2013 |
Gefitinib enhances the efficacy of photodynamic therapy using 5-aminolevulinic acid in malignant brain tumor cells.
Topics: Aminolevulinic Acid; Antineoplastic Agents; Brain Neoplasms; Cell Line, Tumor; Drug Synergism; Drug | 2013 |
5-aminolevulinic acid (5-ALA) fluorescence guided surgery of high-grade gliomas in eloquent areas assisted by functional mapping. Our experience and review of the literature.
Topics: Adult; Aged; Aminolevulinic Acid; Brain Mapping; Brain Neoplasms; Fluorescence; Glioma; Humans; Midd | 2013 |
The use of 5-aminolevulinic acid fluorescence guidance in resection of pediatric brain tumors.
Topics: Adolescent; Aminolevulinic Acid; Brain Neoplasms; Child; Child, Preschool; Female; Glioma; Humans; M | 2013 |
Experimental study to understand nonspecific protoporphyrin IX fluorescence in brain tissues near tumors after 5-aminolevulinic acid administration.
Topics: Aminolevulinic Acid; Animals; Cell Line, Tumor; Fluorescence; Glioma; Meningioma; Protoporphyrins; R | 2013 |
Observational, retrospective study of the effectiveness of 5-aminolevulinic acid in malignant glioma surgery in Spain (The VISIONA study).
Topics: Aminolevulinic Acid; Antineoplastic Agents, Alkylating; Brain Neoplasms; Dacarbazine; Disease-Free S | 2014 |
Aquaporin-4 in glioma and metastatic tissues harboring 5-aminolevulinic acid-induced porphyrin fluorescence.
Topics: Adolescent; Adult; Aged; Aminolevulinic Acid; Animals; Aquaporin 1; Aquaporin 4; Brain Neoplasms; Fe | 2013 |
Low-dose arsenic trioxide enhances 5-aminolevulinic acid-induced PpIX accumulation and efficacy of photodynamic therapy in human glioma.
Topics: Aminolevulinic Acid; Animals; Apoptosis; Arsenic Trioxide; Arsenicals; Cell Line, Tumor; Cell Surviv | 2013 |
Role of intraoperative neurophysiological monitoring during fluorescence-guided resection surgery : Aiming at seemingly complete resection of diffuse gliomas under 5-ALA guidance-Is it safe?
Topics: Aminolevulinic Acid; Brain Mapping; Brain Neoplasms; Female; Glioma; Humans; Intraoperative Neurophy | 2013 |
Calcitriol enhances 5-aminolevulinic acid-induced fluorescence and the effect of photodynamic therapy in human glioma.
Topics: Aminolevulinic Acid; Astrocytes; Brain Neoplasms; Calcitriol; Cell Line, Tumor; Cell Survival; Enzym | 2014 |
Role of intraoperative neurophysiological monitoring during fluorescence-guided resection surgery.
Topics: Adult; Aged; Aminolevulinic Acid; Brain Mapping; Brain Neoplasms; Female; Glioma; Humans; Intraopera | 2013 |
5-Aminolevulinic acid induced fluorescence is a powerful intraoperative marker for precise histopathological grading of gliomas with non-significant contrast-enhancement.
Topics: Adult; Aged; Aminolevulinic Acid; Biomarkers; Brain; Brain Neoplasms; Female; Fluorescence; Glioma; | 2013 |
5-Aminolevulinic acid-derived tumor fluorescence: the diagnostic accuracy of visible fluorescence qualities as corroborated by spectrometry and histology and postoperative imaging.
Topics: Adolescent; Adult; Aged; Aminolevulinic Acid; Biometry; Brain Neoplasms; Female; Glioma; Humans; Mal | 2014 |
A high-throughput photodynamic therapy screening platform with on-chip control of multiple microenvironmental factors.
Topics: Aminolevulinic Acid; Brain Neoplasms; Cell Line, Tumor; Cell Survival; Glioma; Humans; Light; Microf | 2014 |
Cost-effectiveness of 5-aminolevulinic acid-induced fluorescence in malignant glioma surgery.
Topics: Adult; Aged; Aminolevulinic Acid; Brain Neoplasms; Cost-Benefit Analysis; Fluorescence; Glioma; Huma | 2015 |
Fluorescence-guided surgery in high grade gliomas using an exoscope system.
Topics: Adult; Aged; Aminolevulinic Acid; Astrocytoma; Biopsy; Brain Neoplasms; Female; Fluorescent Dyes; Gl | 2014 |
Calcitriol enhances 5-aminolevulinic acid-induced fluorescence and the effect of photodynamic therapy in human glioma.
Topics: Aminolevulinic Acid; Brain Neoplasms; Calcitriol; Fluorescence; Glioma; Humans; Photochemotherapy; P | 2014 |
Malignant glioma: MR imaging by using 5-aminolevulinic acid in an animal model.
Topics: Aminolevulinic Acid; Animals; Brain Neoplasms; Cell Line, Tumor; Contrast Media; Disease Models, Ani | 2014 |
[Determining the tumor-cell density required for macroscopic observation of 5-ALA-induced fluorescence of protoporphyrin IX in cultured glioma cells and clinical cases].
Topics: Adult; Aged; Aminolevulinic Acid; Animals; Brain Neoplasms; Cell Count; Cell Line, Tumor; Female; Gl | 2014 |
Fluorescence-guided surgery and biopsy in gliomas with an exoscope system.
Topics: Adult; Aged; Aminolevulinic Acid; Astrocytoma; Biopsy; Brain Neoplasms; Female; Fluorescence; Glioma | 2014 |
Navigable intraoperative ultrasound and fluorescence-guided resections are complementary in resection control of malignant gliomas: one size does not fit all.
Topics: Adult; Aminolevulinic Acid; Brain Neoplasms; Female; Glioma; Humans; Imaging, Three-Dimensional; Mag | 2014 |
5-aminolevulinic acid (5-ALA) fluorescence in infectious disease of the brain.
Topics: Aged; Aminolevulinic Acid; Brain Diseases; Brain Neoplasms; Central Nervous System Bacterial Infecti | 2014 |
Approaching a brainstem high-grade glioma (HGG) with the assistance of 5-aminolevulinic acid (5-ALA) technology: a new strategy for an old surgical challenge.
Topics: Aminolevulinic Acid; Brain Stem Neoplasms; Female; Glioma; Humans; Magnetic Resonance Imaging; Photo | 2015 |
Predicting the "usefulness" of 5-ALA-derived tumor fluorescence for fluorescence-guided resections in pediatric brain tumors: a European survey.
Topics: Adolescent; Aminolevulinic Acid; Brain Neoplasms; Child; Child, Preschool; Contrast Media; Data Coll | 2014 |
5-Aminolevulinic acid strongly enhances delayed intracellular production of reactive oxygen species (ROS) generated by ionizing irradiation: quantitative analyses and visualization of intracellular ROS production in glioma cells in vitro.
Topics: Aminolevulinic Acid; Animals; Brain Neoplasms; Cell Line, Tumor; Cytoplasm; Glioma; Humans; In Vitro | 2015 |
5-aminolevulinic acid-induced protoporphyrin IX with multi-dose ionizing irradiation enhances host antitumor response and strongly inhibits tumor growth in experimental glioma in vivo.
Topics: Aminolevulinic Acid; Animals; Cell Line, Tumor; Chromatography, High Pressure Liquid; Cytotoxicity, | 2015 |
Fluorescent cancer-selective alkylphosphocholine analogs for intraoperative glioma detection.
Topics: Aminolevulinic Acid; Animals; Brain Neoplasms; Flow Cytometry; Fluorescent Dyes; Glioma; Heterograft | 2015 |
Feasibility of fluorescence-guided resection of recurrent gliomas using five-aminolevulinic acid: retrospective analysis of surgical and neurological outcome in 58 patients.
Topics: Adult; Aged; Aminolevulinic Acid; Brain Neoplasms; Case-Control Studies; Feasibility Studies; Female | 2015 |
Journal club: 5-aminolevulinic acid-derived tumor fluorescence: the diagnostic accuracy of visible fluorescence qualities as corroborated by spectrometry and histology and postoperative imaging.
Topics: Aminolevulinic Acid; Brain Neoplasms; Female; Glioma; Humans; Male; Photosensitizing Agents; Spectru | 2015 |
Response to journal club: 5-aminolevulinic acid-derived tumor fluorescence: the diagnostic accuracy of visible fluorescence qualities as corroborated by spectrometry and histology and postoperative imaging.
Topics: Aminolevulinic Acid; Brain Neoplasms; Female; Glioma; Humans; Male; Photosensitizing Agents; Spectru | 2015 |
Role of neurochemical navigation with 5-aminolevulinic acid during intraoperative MRI-guided resection of intracranial malignant gliomas.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aminolevulinic Acid; Brain Neoplasms; Female; Fluorescen | 2015 |
Colour contrasting between tissues predicts the resection in 5-aminolevulinic acid-guided surgery of malignant gliomas.
Topics: Adult; Aged; Aminolevulinic Acid; Brain Neoplasms; Contrast Media; Diffusion Magnetic Resonance Imag | 2015 |
A pilot cost-effectiveness analysis of treatments in newly diagnosed high-grade gliomas: the example of 5-aminolevulinic Acid compared with white-light surgery.
Topics: Adult; Aged; Aminolevulinic Acid; Brain Neoplasms; Cost-Benefit Analysis; Disease Progression; Femal | 2015 |
Combination of Intraoperative Magnetic Resonance Imaging and Intraoperative Fluorescence to Enhance the Resection of Contrast Enhancing Gliomas.
Topics: Adult; Aged; Aged, 80 and over; Aminolevulinic Acid; Brain Neoplasms; Female; Glioma; Humans; Intrao | 2015 |
Low dose 5-aminolevulinic acid: Implications in spectroscopic measurements during brain tumor surgery.
Topics: Aged; Aminolevulinic Acid; Brain Neoplasms; Dose-Response Relationship, Drug; Female; Fluorescence; | 2015 |
Outcomes after combined use of intraoperative MRI and 5-aminolevulinic acid in high-grade glioma surgery.
Topics: Aminolevulinic Acid; Brain Neoplasms; Contrast Media; Disease-Free Survival; Female; Glioma; Humans; | 2015 |
Comparing high-resolution microscopy techniques for potential intraoperative use in guiding low-grade glioma resections.
Topics: Aminolevulinic Acid; Brain Neoplasms; Glioma; Humans; Intraoperative Care; Microscopy; Neuronavigati | 2015 |
Photodynamic therapy mediated by 5-aminolevulinic acid suppresses gliomas growth by decreasing the microvessels.
Topics: Aminolevulinic Acid; Animals; Brain Neoplasms; Cell Line, Tumor; Glioma; Microvessels; Photochemothe | 2015 |
Intra-operative acidosis during 5-aminolevulinic acid assisted glioma resection.
Topics: Acidosis, Lactic; Aminolevulinic Acid; Brain Neoplasms; Diagnosis, Differential; Fluorescent Dyes; G | 2015 |
Mechanism for enhanced 5-aminolevulinic acid fluorescence in isocitrate dehydrogenase 1 mutant malignant gliomas.
Topics: Aminolevulinic Acid; Brain Neoplasms; Cohort Studies; Glioma; Humans; Isocitrate Dehydrogenase | 2015 |
Quantitative fluorescence using 5-aminolevulinic acid-induced protoporphyrin IX biomarker as a surgical adjunct in low-grade glioma surgery.
Topics: Adult; Aged; Aminolevulinic Acid; Biomarkers; Brain Neoplasms; Female; Fluorescence; Glioma; Humans; | 2015 |
Hyperthermotherapy enhances antitumor effect of 5-aminolevulinic acid-mediated sonodynamic therapy with activation of caspase-dependent apoptotic pathway in human glioma.
Topics: Aminolevulinic Acid; Animals; Apoptosis; Apoptosis Regulatory Proteins; Cell Line, Tumor; Combined M | 2016 |
Safety and Efficacy of 5-Aminolevulinic Acid for High Grade Glioma in Usual Clinical Practice: A Prospective Cohort Study.
Topics: Adult; Aged; Aminolevulinic Acid; Brain Neoplasms; Cohort Studies; Disease Progression; Disease-Free | 2016 |
5-Aminolevulinic Acid Accumulation in a Cerebral Infarction Mimicking High-Grade Glioma.
Topics: Aminolevulinic Acid; Brain Ischemia; Brain Neoplasms; Cerebral Infarction; Craniotomy; Evoked Potent | 2016 |
Histopathological implications of ventricle wall 5-aminolevulinic acid-induced fluorescence in the absence of tumor involvement on magnetic resonance images.
Topics: Aged; Aminolevulinic Acid; Brain Neoplasms; Female; Fluorescence; Glioblastoma; Glioma; Humans; Magn | 2016 |
[5-ALA Sonodynamic Therapy for Malignant Glioma].
Topics: Aminolevulinic Acid; Animals; Brain Neoplasms; Glioma; Humans; Photosensitizing Agents | 2016 |
Insular gliomas and the role of intraoperative assistive technologies: Results from a volumetry-based retrospective cohort.
Topics: Adolescent; Adult; Aminolevulinic Acid; Brain Neoplasms; Cerebral Cortex; Child; Diffusion Tensor Im | 2016 |
Hiding in the Shadows: CPOX Expression and 5-ALA Induced Fluorescence in Human Glioma Cells.
Topics: Aminolevulinic Acid; Brain Neoplasms; Cell Line, Tumor; Coproporphyrinogen Oxidase; Fluorescence; Gl | 2017 |
Intraoperative Near-Infrared Optical Imaging Can Localize Gadolinium-Enhancing Gliomas During Surgery.
Topics: Adult; Aminolevulinic Acid; Brain Neoplasms; Coloring Agents; Contrast Media; Female; Fluorescence; | 2016 |
5-Aminolevulinic acid-mediated sonosensitization of rat RG2 glioma cells in vitro.
Topics: Aminolevulinic Acid; Animals; Apoptosis; Cell Line, Tumor; Cell Survival; Glioma; Rats | 2016 |
Evaluation of the risk of liver damage from the use of 5-aminolevulinic acid for intra-operative identification and resection in patients with malignant gliomas.
Topics: Adult; Aged; Aged, 80 and over; Aminolevulinic Acid; Brain Neoplasms; Female; Glioma; Humans; Liver; | 2017 |
Prediction of genetic subgroups in adult supra tentorial gliomas by pre- and intraoperative parameters.
Topics: Adult; Aminolevulinic Acid; Female; Glioma; Humans; Isocitrate Dehydrogenase; Magnetic Resonance Spe | 2017 |
5-Aminolevulinic acid enhances mitochondrial stress upon ionizing irradiation exposure and increases delayed production of reactive oxygen species and cell death in glioma cells.
Topics: Aminolevulinic Acid; Apoptosis; Biological Transport; Brain Neoplasms; Cell Death; Cell Line, Tumor; | 2017 |
The patients' view: impact of the extent of resection, intraoperative imaging, and awake surgery on health-related quality of life in high-grade glioma patients-results of a multicenter cross-sectional study.
Topics: Adult; Aged; Aminolevulinic Acid; Biopsy; Brain Neoplasms; Cognition; Cross-Sectional Studies; Femal | 2018 |
[Photodynamic therapy mediated with 5-aminolevulinic acid for C6 glioma spheroids].
Topics: Aminolevulinic Acid; Animals; Apoptosis; Cryoultramicrotomy; Glioma; In Situ Nick-End Labeling; Micr | 2008 |
Motexafin gadolinium enhances the efficacy of aminolevulinic acid mediated-photodynamic therapy in human glioma spheroids.
Topics: Aminolevulinic Acid; Antineoplastic Agents; Cell Line, Tumor; Cell Movement; Dose-Response Relations | 2009 |
Intraoperative navigation and fluorescence imagings in malignant glioma surgery.
Topics: Aminolevulinic Acid; Brain; Brain Neoplasms; Disease Progression; Equipment Design; Fluorescent Dyes | 2008 |
Does gross total removal of a brain tumor produce greater longevity?
Topics: Aminolevulinic Acid; Brain Neoplasms; Fluorescence; Glioma; Humans; Longevity; Survival Analysis; Tr | 2009 |
Association of F18-fluoro-ethyl-tyrosin uptake and 5-aminolevulinic acid-induced fluorescence in gliomas.
Topics: Adult; Aged; Aminolevulinic Acid; Biomarkers, Tumor; Brain Neoplasms; Female; Fluorescence; Glioma; | 2009 |
The effects of ultra low fluence rate single and repetitive photodynamic therapy on glioma spheroids.
Topics: Aminolevulinic Acid; Cell Culture Techniques; Cell Survival; Glioma; Humans; Photochemotherapy; Phot | 2009 |
Bulk flow and diffusion revisited, and clinical applications.
Topics: Aminolevulinic Acid; Animals; Brain Edema; Brain Neoplasms; Capillaries; Cerebrovascular Circulation | 2010 |
5-Aminolevulinic acid is a promising marker for detection of anaplastic foci in diffusely infiltrating gliomas with nonsignificant contrast enhancement.
Topics: Adult; Aged; Aminolevulinic Acid; Biomarkers, Tumor; Brain Neoplasms; Female; Glioma; Humans; Intrao | 2010 |
Coregistered fluorescence-enhanced tumor resection of malignant glioma: relationships between δ-aminolevulinic acid-induced protoporphyrin IX fluorescence, magnetic resonance imaging enhancement, and neuropathological parameters. Clinical article.
Topics: Aged; Aged, 80 and over; Aminolevulinic Acid; Biopsy; Brain Neoplasms; Data Interpretation, Statisti | 2011 |
Improving intraoperative visualization of anaplastic foci within gliomas.
Topics: Aminolevulinic Acid; Biopsy; Brain Neoplasms; Carcinoma; Fluorescence; Glioma; Humans; Protoporphyri | 2010 |
[Fluorescence-guided resection with 5-aminolevulinic acid of an intramedullary tumor].
Topics: Aminolevulinic Acid; Brain Neoplasms; Female; Glioma; Humans; Middle Aged; Neurosurgical Procedures; | 2010 |
Anaplastic foci within gliomas.
Topics: Aminolevulinic Acid; Brain Neoplasms; Diagnostic Imaging; Glioma; Humans | 2011 |
Precise comparison of protoporphyrin IX fluorescence spectra with pathological results for brain tumor tissue identification.
Topics: Aminolevulinic Acid; Brain Neoplasms; Glioma; Humans; Photosensitizing Agents; Protoporphyrins; Spec | 2011 |
Silencing of ferrochelatase enhances 5-aminolevulinic acid-based fluorescence and photodynamic therapy efficacy.
Topics: Aminolevulinic Acid; Cell Line, Tumor; Ferrochelatase; Fluorescence; Gene Silencing; Glioma; Humans; | 2011 |
Finding the anaplastic focus in diffuse gliomas: the value of Gd-DTPA enhanced MRI, FET-PET, and intraoperative, ALA-derived tissue fluorescence.
Topics: Adult; Aminolevulinic Acid; Biopsy; Brain Neoplasms; Carcinoma; Contrast Media; Female; Fluorescence | 2011 |
Modulation of migratory activity and invasiveness of human glioma spheroids following 5-aminolevulinic acid-based photodynamic treatment. Laboratory investigation.
Topics: Aminolevulinic Acid; Brain Neoplasms; Cell Line, Tumor; Cell Movement; Cell Survival; Glioma; Humans | 2011 |
Morphological and histological changes of glioma cells immediately after 5-aminolevulinic acid mediated photodynamic therapy.
Topics: Aminolevulinic Acid; Animals; Brain Neoplasms; Cell Line, Tumor; Cell Size; Combined Modality Therap | 2011 |
Intraoperative confocal microscopy in the visualization of 5-aminolevulinic acid fluorescence in low-grade gliomas.
Topics: Adult; Aminolevulinic Acid; Brain; Brain Neoplasms; Female; Glioma; Humans; Intraoperative Period; M | 2011 |
Intraoperative confocal microscopy in the visualization of 5-aminolevulinic acid fluorescence in low-grade gliomas.
Topics: Adult; Aminolevulinic Acid; Brain; Brain Neoplasms; Female; Glioma; Humans; Intraoperative Period; M | 2011 |
Intraoperative confocal microscopy in the visualization of 5-aminolevulinic acid fluorescence in low-grade gliomas.
Topics: Adult; Aminolevulinic Acid; Brain; Brain Neoplasms; Female; Glioma; Humans; Intraoperative Period; M | 2011 |
Intraoperative confocal microscopy in the visualization of 5-aminolevulinic acid fluorescence in low-grade gliomas.
Topics: Adult; Aminolevulinic Acid; Brain; Brain Neoplasms; Female; Glioma; Humans; Intraoperative Period; M | 2011 |
Use of 5-aminolevulinic acid for visualization of low-grade gliomas.
Topics: Aminolevulinic Acid; Brain; Brain Neoplasms; Female; Glioma; Humans; Male; Microscopy, Confocal; Pho | 2011 |
Fluorescence illuminates the way ...
Topics: Aminolevulinic Acid; Biomarkers; Brain Neoplasms; Female; Glioma; Humans; Male; Monitoring, Intraope | 2011 |
δ-aminolevulinic acid-induced protoporphyrin IX concentration correlates with histopathologic markers of malignancy in human gliomas: the need for quantitative fluorescence-guided resection to identify regions of increasing malignancy.
Topics: Adult; Aged; Aminolevulinic Acid; Biomarkers; Brain Neoplasms; Diagnostic Imaging; Female; Fluoresce | 2011 |
¹¹C-methionine uptake and intraoperative 5-aminolevulinic acid-induced fluorescence as separate index markers of cell density in glioma: a stereotactic image-histological analysis.
Topics: Adult; Aged; Aminolevulinic Acid; Brain Neoplasms; Carbon Radioisotopes; Cell Count; Cell Proliferat | 2012 |
Sonodynamic therapy with 5-aminolevulinic acid and focused ultrasound for deep-seated intracranial glioma in rat.
Topics: Aminolevulinic Acid; Animals; Brain Neoplasms; Cell Line, Tumor; Craniotomy; Drug Screening Assays, | 2011 |
Combined fluorescence and reflectance spectroscopy for in vivo quantification of cancer biomarkers in low- and high-grade glioma surgery.
Topics: Aminolevulinic Acid; Biomarkers, Tumor; Diagnostic Imaging; Glioma; Humans; Models, Biological; Prot | 2011 |
Radiosensitizing effect of 5-aminolevulinic acid-induced protoporphyrin IX in glioma cells in vitro.
Topics: Aminolevulinic Acid; Animals; Cell Line, Tumor; Glioma; Protoporphyrins; Radiation-Sensitizing Agent | 2012 |
Strong 5-aminolevulinic acid-induced fluorescence is a novel intraoperative marker for representative tissue samples in stereotactic brain tumor biopsies.
Topics: Adult; Aged; Aged, 80 and over; Aminolevulinic Acid; Biopsy; Brain Neoplasms; Female; Fluorescence; | 2012 |
Neurolasermicroscopy.
Topics: Aminolevulinic Acid; Brain; Brain Neoplasms; Female; Glioma; Humans; Male; Microscopy, Confocal; Pho | 2012 |
5-aminolevulinic acid and neuronavigation in high-grade glioma surgery: results of a combined approach.
Topics: Aminolevulinic Acid; Brain Neoplasms; Glioma; Humans; Neuronavigation; Reproducibility of Results | 2012 |
Phenytoin reduces 5-aminolevulinic acid-induced protoporphyrin IX accumulation in malignant glioma cells.
Topics: Aminolevulinic Acid; Anticonvulsants; Fluorescence; Glioma; Glutathione; Humans; Levetiracetam; Memb | 2012 |
Increased expression of ABCB6 enhances protoporphyrin IX accumulation and photodynamic effect in human glioma.
Topics: Aminolevulinic Acid; Apoptosis; ATP-Binding Cassette Transporters; Blotting, Western; Brain; Brain N | 2013 |
Brain biopsy.
Topics: Aminolevulinic Acid; Biopsy; Brain; Brain Neoplasms; Glioma; Humans; Meningeal Neoplasms; Meningioma | 2012 |
Automatic laser scanning ablation system for high-precision treatment of brain tumors.
Topics: Aminolevulinic Acid; Animals; Brain; Brain Neoplasms; Equipment Design; Glioma; Humans; Laser Therap | 2013 |
Gadolinium- and 5-aminolevulinic acid-induced protoporphyrin IX levels in human gliomas: an ex vivo quantitative study to correlate protoporphyrin IX levels and blood-brain barrier breakdown.
Topics: Aminolevulinic Acid; Blood-Brain Barrier; Brain Neoplasms; Craniotomy; Creatinine; Female; Gadoliniu | 2012 |
Improving the extent of malignant glioma resection by dual intraoperative visualization approach.
Topics: Adult; Aged; Aminolevulinic Acid; Brain; Brain Neoplasms; Female; Fluorescent Dyes; Glioma; Humans; | 2012 |
Sonodynamically induced antitumor effects of 5-aminolevulinic acid and fractionated ultrasound irradiation in an orthotopic rat glioma model.
Topics: Aminolevulinic Acid; Animals; Antineoplastic Agents; Brain Neoplasms; Female; Glioma; Phantoms, Imag | 2012 |
ALA- and ALA-ester-mediated photodynamic therapy of human glioma spheroids.
Topics: Aminolevulinic Acid; Brain Neoplasms; Cell Survival; Dose-Response Relationship, Drug; Esters; Gliom | 2002 |
Photoirradiation therapy of experimental malignant glioma with 5-aminolevulinic acid.
Topics: Aminolevulinic Acid; Animals; Antineoplastic Agents; Brain; Brain Edema; Brain Neoplasms; Dihematopo | 2002 |
Protoporphyrin IX production and its photodynamic effects on glioma cells, neuroblastoma cells and normal cerebellar granule cells in vitro with 5-aminolevulinic acid and its hexylester.
Topics: Aminolevulinic Acid; Animals; Brain Neoplasms; Cell Line; Cerebellum; Glioma; Humans; Neuroblastoma; | 2003 |
Increased brain tumor resection using fluorescence image guidance in a preclinical model.
Topics: Aminolevulinic Acid; Animals; Brain Neoplasms; Glioma; Microscopy; Models, Animal; Neoplasm, Residua | 2004 |
Oedema formation in experimental photo-irradiation therapy of brain tumours using 5-ALA.
Topics: Aminolevulinic Acid; Animals; Brain Edema; Brain Neoplasms; Dexamethasone; Disease Models, Animal; G | 2005 |
Enhanced cytotoxic effects of 5-aminolevulinic acid-mediated photodynamic therapy by concurrent hyperthermia in glioma spheroids.
Topics: Aminolevulinic Acid; Animals; Apoptosis; Brain Neoplasms; Glioma; Humans; Hyperthermia, Induced; In | 2004 |
Photodynamic therapy of newly implanted glioma cells in the rat brain.
Topics: Aminolevulinic Acid; Animals; Brain; Brain Neoplasms; Cell Line, Tumor; Disease Models, Animal; Drug | 2006 |
Influence of light fluence rate on the effects of photodynamic therapy in an orthotopic rat glioma model.
Topics: Aminolevulinic Acid; Animals; Brain Neoplasms; Disease Models, Animal; Glioma; Light; Necrosis; Phot | 2006 |
Differential effects of photofrin, 5-aminolevulinic acid and calphostin C on glioma cells.
Topics: Aminolevulinic Acid; Cell Adhesion; Cell Adhesion Molecules; Cell Line, Tumor; Cell Proliferation; D | 2006 |
Minimally invasive photodynamic therapy (PDT) for ablation of experimental rat glioma.
Topics: Aminolevulinic Acid; Animals; Brain Neoplasms; Feasibility Studies; Female; Glioma; Male; Photochemo | 2006 |
Acute morphological sequelae of photodynamic therapy with 5-aminolevulinic acid in the C6 spheroid model.
Topics: Aminolevulinic Acid; Animals; Apoptosis; Brain Neoplasms; Glioma; Mice; Photochemotherapy; Photosens | 2007 |
Effects of ALA-mediated photodynamic therapy on the invasiveness of human glioma cells.
Topics: Aminolevulinic Acid; Brain Neoplasms; Cell Physiological Phenomena; Dose-Response Relationship, Drug | 2006 |
[5-ALA fluorescence guided tumor resection].
Topics: Aminolevulinic Acid; Brain Neoplasms; Female; Fluorescence; Glioma; Humans; Middle Aged; Mitochondri | 2006 |
Massive apoptotic cell death of human glioma cells via a mitochondrial pathway following 5-aminolevulinic acid-mediated photodynamic therapy.
Topics: Aminolevulinic Acid; Apoptosis; Brain Neoplasms; Caspase 3; Caspase 9; Cell Line, Tumor; Cytochromes | 2007 |
Two-photon photodynamic therapy of C6 cells by means of 5-aminolevulinic acid induced protoporphyrin IX.
Topics: Aminolevulinic Acid; Animals; Cell Line; Cell Line, Tumor; Cell Survival; Dose-Response Relationship | 2007 |
Histological examination of false positive tissue resection using 5-aminolevulinic acid-induced fluorescence guidance.
Topics: Aminolevulinic Acid; Brain Neoplasms; False Positive Reactions; Fluorescence; Glioma; Humans; Photos | 2007 |
Interstitial photodynamic therapy of nonresectable malignant glioma recurrences using 5-aminolevulinic acid induced protoporphyrin IX.
Topics: Adult; Aged; Aminolevulinic Acid; Brain Neoplasms; Feasibility Studies; Glioma; Humans; Magnetic Res | 2007 |
Utility of the F98 rat glioma model for photodynamic therapy.
Topics: Aminolevulinic Acid; Animals; Brain; Brain Neoplasms; Cell Line, Tumor; Cell Survival; Dose-Response | 2007 |
5-aminolevulinic acid induced protoporphyrin IX fluorescence in high-grade glioma surgery: a one-year experience at a single institutuion.
Topics: Aminolevulinic Acid; Biopsy; Fluorescence; Glioma; Humans; Prognosis; Protoporphyrins; Sensitivity a | 2008 |
Multiphoton excitation fluorescence microscopy of 5-aminolevulinic acid induced fluorescence in experimental gliomas.
Topics: Aminolevulinic Acid; Animals; Brain Neoplasms; Cell Line, Tumor; Glioma; Humans; Mice; Microscopy, F | 2008 |
Intraoperative detection of malignant gliomas by 5-aminolevulinic acid-induced porphyrin fluorescence.
Topics: Aged; Aminolevulinic Acid; Brain Neoplasms; Female; Fluorescence; Fluorometry; Glioma; Humans; Intra | 1998 |
5-Aminolevulinic acid induced endogenous porphyrin fluorescence in 9L and C6 brain tumours and in the normal rat brain.
Topics: Aminolevulinic Acid; Animals; Brain; Brain Neoplasms; Disease Models, Animal; Glioma; Gliosarcoma; M | 1998 |
Uptake and kinetics of 14C-labelled meta-tetrahydroxyphenylchlorin and 5-aminolaevulinic acid in the C6 rat glioma model.
Topics: Aminolevulinic Acid; Animals; Brain; Brain Neoplasms; Carbon Radioisotopes; Disease Models, Animal; | 1998 |
Technical principles for protoporphyrin-IX-fluorescence guided microsurgical resection of malignant glioma tissue.
Topics: Aminolevulinic Acid; Brain; Brain Neoplasms; Glioma; Humans; Image Processing, Computer-Assisted; Mi | 1998 |
In vitro and in vivo porphyrin accumulation by C6 glioma cells after exposure to 5-aminolevulinic acid.
Topics: Aminolevulinic Acid; Animals; Disease Models, Animal; Glioma; Humans; Male; Photosensitizing Agents; | 1998 |
Comparative study on the ALA photodynamic effects of human glioma and meningioma cells.
Topics: Aminolevulinic Acid; Analysis of Variance; Dose-Response Relationship, Radiation; Epidermal Growth F | 1999 |
Development of a novel indwelling balloon applicator for optimizing light delivery in photodynamic therapy.
Topics: Aminolevulinic Acid; Brain Neoplasms; Catheters, Indwelling; Cell Survival; Equipment Design; Glioma | 2001 |
Characterization of plasma-derived protoporphyrin-IX-positive extracellular vesicles following 5-ALA use in patients with malignant glioma.
Topics: Adult; Aged; Aminolevulinic Acid; Animals; Cell Line, Tumor; Cell Survival; Disease Models, Animal; | 2019 |
Enhancing selective photosensitizer accumulation and oxygen supply for high-efficacy photodynamic therapy toward glioma by 5-aminolevulinic acid loaded nanoplatform.
Topics: Aminolevulinic Acid; Antineoplastic Agents; Biocompatible Materials; Brain Neoplasms; Cell Prolifera | 2020 |
Dual-labeling with 5-aminolevulinic acid and fluorescein for fluorescence-guided resection of high-grade gliomas: technical note.
Topics: Aminolevulinic Acid; Brain Neoplasms; Female; Fluorescein; Fluorescence; Fluorescent Dyes; Glioma; H | 2018 |
Neurosurgical microscopic solid laser-based light inhibits photobleaching during fluorescence-guided brain tumor removal with 5-aminolevulinic acid.
Topics: Aminolevulinic Acid; Animals; Cell Line, Tumor; Glioma; Levulinic Acids; Neurosurgical Procedures; O | 2017 |
Sonodynamic Therapy for Malignant Glioma Using 220-kHz Transcranial Magnetic Resonance Imaging-Guided Focused Ultrasound and 5-Aminolevulinic acid.
Topics: Aminolevulinic Acid; Animals; Brain; Brain Neoplasms; Cell Line, Tumor; Cells, Cultured; Combined Mo | 2019 |
Enhancement of 5-aminolevulinic acid-based fluorescence detection of side population-defined glioma stem cells by iron chelation.
Topics: Aminolevulinic Acid; Animals; ATP Binding Cassette Transporter, Subfamily G, Member 2; Biotransforma | 2017 |