Page last updated: 2024-10-16

aminolevulinic acid and Fifth Phacomatosis

aminolevulinic acid has been researched along with Fifth Phacomatosis in 17 studies

Aminolevulinic Acid: A compound produced from succinyl-CoA and GLYCINE as an intermediate in heme synthesis. It is used as a PHOTOCHEMOTHERAPY for actinic KERATOSIS.
5-aminolevulinic acid : The simplest delta-amino acid in which the hydrogens at the gamma position are replaced by an oxo group. It is metabolised to protoporphyrin IX, a photoactive compound which accumulates in the skin. Used (in the form of the hydrochloride salt)in combination with blue light illumination for the treatment of minimally to moderately thick actinic keratosis of the face or scalp.

Research Excerpts

ExcerptRelevanceReference
" To prevent treatment discomfort, analgesics and/or cooling by sprayed water were most often provided, and occasionally 1% lidocaine local anesthesia."3.79Treatment of Gorlin syndrome (nevoid basal cell carcinoma syndrome) with methylaminolevulinate photodynamic therapy in seven patients, including two children: interest of tumescent anesthesia for pain control in children. ( Bessis, D; Blatière, V; Debu, A; Dereure, O; Girard, C; Guillot, B, 2013)
"No new basal cell carcinomas were observed during the 8-month follow-up period in areas treated with a broad application technique."2.42delta-Aminolevulinic acid and blue light photodynamic therapy for treatment of multiple basal cell carcinomas in two patients with nevoid basal cell carcinoma syndrome. ( Gilchrest, BA; Itkin, A, 2004)
"Patients with nevoid basal cell carcinoma syndrome suffer from multiple basal cell carcinomas, requiring numerous surgical procedures that over time leave them with multiple disfiguring scars."2.42delta-Aminolevulinic acid and blue light photodynamic therapy for treatment of multiple basal cell carcinomas in two patients with nevoid basal cell carcinoma syndrome. ( Gilchrest, BA; Itkin, A, 2004)
"We report treatment of two nevoid basal cell carcinoma syndrome patients, women aged 21 and 47, with 20%delta-aminolevulinic acid solution and 417-nm blue light source (irradiance 10 mW/cm(2))."2.42delta-Aminolevulinic acid and blue light photodynamic therapy for treatment of multiple basal cell carcinomas in two patients with nevoid basal cell carcinoma syndrome. ( Gilchrest, BA; Itkin, A, 2004)
"Patients with Gorlin syndrome develop multiple basal cell carcinomas (BCC), for which treatment is often difficult."1.40Consensus recommendations for the treatment of basal cell carcinomas in Gorlin syndrome with topical methylaminolaevulinate-photodynamic therapy. ( Basset-Seguin, N; Bissonnette, R; Girard, C; Haedersdal, M; Lear, JT; Paul, C; Piaserico, S, 2014)
" For laser treatments, a sigmoidal light dose-response relationship predicted more than 85% initial response rates for light doses 150 J/cm(2) or more."1.33Treatment of diffuse basal cell carcinomas and basaloid follicular hamartomas in nevoid basal cell carcinoma syndrome by wide-area 5-aminolevulinic acid photodynamic therapy. ( Bellnier, DA; Blumenson, LE; Cheney, R; Frawley, NP; Oseroff, AR; Pivnick, EK; Shieh, S, 2005)
"Exclusion of unilateral nevoid basal cell carcinoma syndrome is indicated."1.33Unilateral Basal cell carcinomas: an unusual entity treated with photodynamic therapy. ( Allen, JH; Lane, JE; Lane, TN; Lesher, JL, 2005)
"Like nevoid basal cell carcinoma syndrome, unilateral basal cell carcinomas poses a therapeutic challenge with the sheer number of cutaneous tumors."1.33Unilateral Basal cell carcinomas: an unusual entity treated with photodynamic therapy. ( Allen, JH; Lane, JE; Lane, TN; Lesher, JL, 2005)

Research

Studies (17)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's2 (11.76)18.2507
2000's7 (41.18)29.6817
2010's6 (35.29)24.3611
2020's2 (11.76)2.80

Authors

AuthorsStudies
Thompson, A1
Mattia, A1
Green, WH2
Cognetta, AB2
Li, C1
Chen, P1
Li, Z1
Wang, Y1
He, S1
Shi, M1
Wang, Q1
Xu, M1
Li, Q1
Chen, H1
Zeng, K1
Liang, J1
Zhang, X1
Maytin, EV1
Kaw, U1
Ilyas, M1
Mack, JA1
Hu, B1
Basset-Seguin, N3
Bissonnette, R2
Girard, C2
Haedersdal, M1
Lear, JT1
Paul, C2
Piaserico, S1
Miguélez, A1
Martín-Santiago, A1
Bauzá, A1
Gilaberte, Y1
Mougel, F1
Debarbieux, S1
Ronger-Savlé, S1
Dalle, S1
Thomas, L1
Gilchrest, BA2
Brightman, LA1
Thiele, JJ1
Wasserman, DI1
Pauwels, C1
Mazereeuw-Hautier, J1
Livideanu, C1
Viraben, R1
Meyer, N1
Debu, A1
Bessis, D1
Blatière, V1
Dereure, O1
Guillot, B1
Wolfe, CM1
Hatfield, HK1
Haylett, AK1
Ward, TH1
Moore, JV1
Itkin, A1
Oseroff, AR1
Shieh, S1
Frawley, NP1
Cheney, R1
Blumenson, LE1
Pivnick, EK1
Bellnier, DA1
Lane, JE1
Allen, JH1
Lane, TN1
Lesher, JL1
Braathen, LR1
Szeimies, RM2
Foley, P1
Pariser, D1
Roelandts, R1
Wennberg, AM1
Morton, CA1
Wolf, P1
Kerl, H1
Karrer, S1
Hohenleutner, U1
Heine, A1
Landthaler, M1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Evaluation of the Formulation of 5-aminolevulinic Acid With Dimethylsulfoxide in Photodynamic Therapy for Treatment of Actinic Keratosis[NCT01459393]Phase 3137 participants (Actual)Interventional2010-11-30Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

2 reviews available for aminolevulinic acid and Fifth Phacomatosis

ArticleYear
delta-Aminolevulinic acid and blue light photodynamic therapy for treatment of multiple basal cell carcinomas in two patients with nevoid basal cell carcinoma syndrome.
    Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.], 2004, Volume: 30, Issue:7

    Topics: Adult; Aminolevulinic Acid; Basal Cell Nevus Syndrome; Carcinoma, Basal Cell; Female; Humans; Middle

2004
Guidelines on the use of photodynamic therapy for nonmelanoma skin cancer: an international consensus. International Society for Photodynamic Therapy in Dermatology, 2005.
    Journal of the American Academy of Dermatology, 2007, Volume: 56, Issue:1

    Topics: Aminolevulinic Acid; Australia; Basal Cell Nevus Syndrome; Bowen's Disease; Carcinoma, Basal Cell; C

2007

Trials

1 trial available for aminolevulinic acid and Fifth Phacomatosis

ArticleYear
Blue light versus red light for photodynamic therapy of basal cell carcinoma in patients with Gorlin syndrome: A bilaterally controlled comparison study.
    Photodiagnosis and photodynamic therapy, 2018, Volume: 22

    Topics: Adult; Aminolevulinic Acid; Basal Cell Nevus Syndrome; Carcinoma, Basal Cell; Female; Humans; Light;

2018

Other Studies

14 other studies available for aminolevulinic acid and Fifth Phacomatosis

ArticleYear
A 10-year follow-up on the chemopreventive role of photodynamic therapy in a Gorlin syndrome patient.
    The Australasian journal of dermatology, 2022, Volume: 63, Issue:4

    Topics: Aminolevulinic Acid; Basal Cell Nevus Syndrome; Carcinoma, Basal Cell; Follow-Up Studies; Humans; Ph

2022
5-aminolevulinic acid photodynamic therapy and excision surgery for nevoid basal cell carcinoma syndrome with multiple basal cell carcinomas and PTCH1 mutation.
    Photodiagnosis and photodynamic therapy, 2020, Volume: 32

    Topics: Aminolevulinic Acid; Basal Cell Nevus Syndrome; Carcinoma, Basal Cell; Hamartoma Syndrome, Multiple;

2020
Consensus recommendations for the treatment of basal cell carcinomas in Gorlin syndrome with topical methylaminolaevulinate-photodynamic therapy.
    Journal of the European Academy of Dermatology and Venereology : JEADV, 2014, Volume: 28, Issue:5

    Topics: Administration, Topical; Adult; Aged; Aminolevulinic Acid; Basal Cell Nevus Syndrome; Carcinoma, Bas

2014
Urticaria-like reaction secondary to photodynamic therapy in 2 pediatric patients.
    Actas dermo-sifiliograficas, 2013, Volume: 104, Issue:8

    Topics: Aminolevulinic Acid; Basal Cell Nevus Syndrome; Child; Child, Preschool; Female; Humans; Neoplasms,

2013
Methylaminolaevulinate photodynamic therapy in patients with multiple basal cell carcinomas in the setting of Gorlin-Goltz syndrome or after radiotherapy.
    Dermatology (Basel, Switzerland), 2009, Volume: 219, Issue:2

    Topics: Adult; Aged; Aminolevulinic Acid; Basal Cell Nevus Syndrome; Cohort Studies; Combined Modality Thera

2009
Photodynamic therapy for patients with Basal cell nevus syndrome.
    Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.], 2009, Volume: 35, Issue:10

    Topics: Aged; Aminolevulinic Acid; Basal Cell Nevus Syndrome; Female; Humans; Male; Middle Aged; Photochemot

2009
Topical methyl aminolevulinate photodynamic therapy for management of basal cell carcinomas in patients with basal cell nevus syndrome improves patient's satisfaction and reduces the need for surgical procedures.
    Journal of the European Academy of Dermatology and Venereology : JEADV, 2011, Volume: 25, Issue:7

    Topics: Aminolevulinic Acid; Basal Cell Nevus Syndrome; Humans; Patient Satisfaction; Photochemotherapy; Ski

2011
Treatment of Gorlin syndrome (nevoid basal cell carcinoma syndrome) with methylaminolevulinate photodynamic therapy in seven patients, including two children: interest of tumescent anesthesia for pain control in children.
    Journal of the European Academy of Dermatology and Venereology : JEADV, 2013, Volume: 27, Issue:2

    Topics: Adolescent; Adult; Aminolevulinic Acid; Anesthesia; Basal Cell Nevus Syndrome; Child; Female; Humans

2013
Urticaria after methyl aminolevulinate photodynamic therapy in a patient with nevoid basal cell carcinoma syndrome.
    Journal of drugs in dermatology : JDD, 2012, Volume: 11, Issue:11

    Topics: Aminolevulinic Acid; Basal Cell Nevus Syndrome; Carcinoma, Basal Cell; Female; Humans; Middle Aged;

2012
DNA damage and repair in Gorlin syndrome and normal fibroblasts after aminolevulinic acid photodynamic therapy: a comet assay study.
    Photochemistry and photobiology, 2003, Volume: 78, Issue:4

    Topics: Aminolevulinic Acid; Basal Cell Nevus Syndrome; Cell Survival; Comet Assay; DNA Damage; DNA Repair;

2003
Treatment of diffuse basal cell carcinomas and basaloid follicular hamartomas in nevoid basal cell carcinoma syndrome by wide-area 5-aminolevulinic acid photodynamic therapy.
    Archives of dermatology, 2005, Volume: 141, Issue:1

    Topics: Adolescent; Aminolevulinic Acid; Basal Cell Nevus Syndrome; Child; Female; Hamartoma Syndrome, Multi

2005
Unilateral Basal cell carcinomas: an unusual entity treated with photodynamic therapy.
    Journal of cutaneous medicine and surgery, 2005, Volume: 9, Issue:6

    Topics: Aminolevulinic Acid; Basal Cell Nevus Syndrome; Carcinoma, Basal Cell; Diagnosis, Differential; Foll

2005
Photodynamic therapy with 5-aminolevulinic acid: a promising concept for the treatment of cutaneous tumors.
    Dermatology (Basel, Switzerland), 1995, Volume: 190, Issue:3

    Topics: Administration, Cutaneous; Aged; Aminolevulinic Acid; Basal Cell Nevus Syndrome; Female; Humans; Las

1995
Unilateral localized basaliomatosis: treatment with topical photodynamic therapy after application of 5-aminolevulinic acid.
    Dermatology (Basel, Switzerland), 1995, Volume: 190, Issue:3

    Topics: Administration, Cutaneous; Aged; Aminolevulinic Acid; Basal Cell Nevus Syndrome; Carcinoma, Basal Ce

1995