aminolevulinic acid has been researched along with Colorectal Neoplasms in 21 studies
Aminolevulinic Acid: A compound produced from succinyl-CoA and GLYCINE as an intermediate in heme synthesis. It is used as a PHOTOCHEMOTHERAPY for actinic KERATOSIS.
5-aminolevulinic acid : The simplest delta-amino acid in which the hydrogens at the gamma position are replaced by an oxo group. It is metabolised to protoporphyrin IX, a photoactive compound which accumulates in the skin. Used (in the form of the hydrochloride salt)in combination with blue light illumination for the treatment of minimally to moderately thick actinic keratosis of the face or scalp.
Colorectal Neoplasms: Tumors or cancer of the COLON or the RECTUM or both. Risk factors for colorectal cancer include chronic ULCERATIVE COLITIS; FAMILIAL POLYPOSIS COLI; exposure to ASBESTOS; and irradiation of the CERVIX UTERI.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Folic acid can be covalently conjugated to chitosan molecules via its gamma-carboxyl moiety and thus retain a high affinity for colorectal cancer cells bearing folate receptor overexpression." | 7.76 | Folic acid-conjugated chitosan nanoparticles enhanced protoporphyrin IX accumulation in colorectal cancer cells. ( Lin, FH; Shieh, MJ; Tsai, HM; Tsai, KC; Wei, MF; Wong, JM; Yang, SJ, 2010) |
| "5-aminolevulinic acid (5-ALA) is an intermediate substrate of heme metabolism." | 5.40 | Fluorescent detection of peritoneal metastasis in human colorectal cancer using 5-aminolevulinic acid. ( Fujiwara, H; Ichikawa, D; Ikoma, H; Inoue, K; Komatsu, S; Kondo, Y; Konishi, H; Kubota, T; Kuriu, Y; Morimura, R; Murayama, Y; Nakajima, M; Nakanishi, M; Okamoto, K; Otsuji, E; Sakakura, C; Shiozaki, A; Takahashi, K, 2014) |
| "Twelve colorectal cancer patients suspected to have serosal invasion according to preoperative computed tomography (CT) were enrolled in this study." | 5.40 | Fluorescent detection of peritoneal metastasis in human colorectal cancer using 5-aminolevulinic acid. ( Fujiwara, H; Ichikawa, D; Ikoma, H; Inoue, K; Komatsu, S; Kondo, Y; Konishi, H; Kubota, T; Kuriu, Y; Morimura, R; Murayama, Y; Nakajima, M; Nakanishi, M; Okamoto, K; Otsuji, E; Sakakura, C; Shiozaki, A; Takahashi, K, 2014) |
| "Colorectal cancer is one of the leading causes of malignant death and often goes undetected with current colonoscopy practices." | 5.36 | Folic acid-conjugated chitosan nanoparticles enhanced protoporphyrin IX accumulation in colorectal cancer cells. ( Lin, FH; Shieh, MJ; Tsai, HM; Tsai, KC; Wei, MF; Wong, JM; Yang, SJ, 2010) |
| "Colorectal cancer is one of the leading causes of malignant death in Taiwan because it often remains undetected until later stages of the disease." | 5.35 | Colorectal cancer cell detection by 5-aminolaevulinic acid-loaded chitosan nano-particles. ( Lai, PS; Lin, FH; Lou, PJ; Peng, CL; Shieh, MJ; Wei, MF; Yang, SJ; Yao, CJ; Young, TH, 2009) |
| "5-aminolevulinic acid (5-ALA)-based fluorescence diagnosis is now clinically applied for accurate and ultrarapid diagnosis of malignant lesions such as lymph node metastasis during surgery." | 3.83 | Simplified and optimized multispectral imaging for 5-ALA-based fluorescence diagnosis of malignant lesions. ( Harada, Y; Kato, Y; Matsuo, H; Minamikawa, T; Otsuji, E; Takamatsu, T; Tanaka, H; Yanagisawa, A, 2016) |
| " The aim of this study was to investigate the expression of IGF-2 after 5-aminolevulinic acid (5-ALA)-mediated-PDT in SW620 human colorectal cancer cells with evaluation of cell proliferation and apoptosis and to determine the effects of PDT on the IGF-2 receptor (IGF-2R), IGF-2 binding protein-1 (IGF-2BP-1) and the proapoptotic protein, BAX." | 3.81 | Insulin-Like Growth Factor-2 Is Induced Following 5-Aminolevulinic Acid-Mediated Photodynamic Therapy in SW620 Human Colon Cancer Cell Line. ( Duś-Szachniewicz, K; Woźniak, M; Ziółkowski, P, 2015) |
| "Folic acid can be covalently conjugated to chitosan molecules via its gamma-carboxyl moiety and thus retain a high affinity for colorectal cancer cells bearing folate receptor overexpression." | 3.76 | Folic acid-conjugated chitosan nanoparticles enhanced protoporphyrin IX accumulation in colorectal cancer cells. ( Lin, FH; Shieh, MJ; Tsai, HM; Tsai, KC; Wei, MF; Wong, JM; Yang, SJ, 2010) |
| "Human colorectal cancer cells of different malignant potential SW480 and SW620 were used in the experiment." | 1.46 | The effect of ALA-PDT under normoxia and cobalt chloride (CoCl ( Czuba, ZP; Kawczyk-Krupka, A; Krupka, M; Kwiatek, B; Kwiatek, S; Sieroń, K, 2017) |
| "Subjects were patients with gastric or colorectal tumors who had undergone endoscopic resection between November 2012 and November 2013." | 1.42 | Preliminary study of photodynamic diagnosis using 5-aminolevulinic acid in gastric and colorectal tumors. ( Goto, A; Hamabe, K; Hashimoto, S; Nagao, M; Nakamura, M; Nishikawa, J; Nishimura, J; Okamoto, T; Sakaida, I; Sasaki, S; Shibata, H, 2015) |
| "5-ALA fluorescence was detected in all hepatocellular carcinoma cases with serosa invasion." | 1.40 | Fluorescence detection of malignant liver tumors using 5-aminolevulinic acid-mediated photodynamic diagnosis: principles, technique, and clinical experience. ( Hayashi, M; Hirokawa, F; Inoue, Y; Komeda, K; Tanaka, R; Uchiyama, K, 2014) |
| "In liver metastasis from colorectal cancer cases with serosa invasion, 18 patients (85." | 1.40 | Fluorescence detection of malignant liver tumors using 5-aminolevulinic acid-mediated photodynamic diagnosis: principles, technique, and clinical experience. ( Hayashi, M; Hirokawa, F; Inoue, Y; Komeda, K; Tanaka, R; Uchiyama, K, 2014) |
| "5-aminolevulinic acid (5-ALA) is an intermediate substrate of heme metabolism." | 1.40 | Fluorescent detection of peritoneal metastasis in human colorectal cancer using 5-aminolevulinic acid. ( Fujiwara, H; Ichikawa, D; Ikoma, H; Inoue, K; Komatsu, S; Kondo, Y; Konishi, H; Kubota, T; Kuriu, Y; Morimura, R; Murayama, Y; Nakajima, M; Nakanishi, M; Okamoto, K; Otsuji, E; Sakakura, C; Shiozaki, A; Takahashi, K, 2014) |
| "Twelve colorectal cancer patients suspected to have serosal invasion according to preoperative computed tomography (CT) were enrolled in this study." | 1.40 | Fluorescent detection of peritoneal metastasis in human colorectal cancer using 5-aminolevulinic acid. ( Fujiwara, H; Ichikawa, D; Ikoma, H; Inoue, K; Komatsu, S; Kondo, Y; Konishi, H; Kubota, T; Kuriu, Y; Morimura, R; Murayama, Y; Nakajima, M; Nakanishi, M; Okamoto, K; Otsuji, E; Sakakura, C; Shiozaki, A; Takahashi, K, 2014) |
| "Colorectal cancer is one of the leading causes of malignant death and often goes undetected with current colonoscopy practices." | 1.36 | Folic acid-conjugated chitosan nanoparticles enhanced protoporphyrin IX accumulation in colorectal cancer cells. ( Lin, FH; Shieh, MJ; Tsai, HM; Tsai, KC; Wei, MF; Wong, JM; Yang, SJ, 2010) |
| "Colorectal cancer is one of the leading causes of malignant death in Taiwan because it often remains undetected until later stages of the disease." | 1.35 | Colorectal cancer cell detection by 5-aminolaevulinic acid-loaded chitosan nano-particles. ( Lai, PS; Lin, FH; Lou, PJ; Peng, CL; Shieh, MJ; Wei, MF; Yang, SJ; Yao, CJ; Young, TH, 2009) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (14.29) | 18.2507 |
| 2000's | 4 (19.05) | 29.6817 |
| 2010's | 12 (57.14) | 24.3611 |
| 2020's | 2 (9.52) | 2.80 |
| Authors | Studies |
|---|---|
| Shi, X | 1 |
| Zhang, H | 1 |
| Jin, W | 1 |
| Liu, W | 1 |
| Yin, H | 1 |
| Li, Y | 1 |
| Dong, H | 1 |
| Kato, T | 1 |
| Iwasaki, T | 1 |
| Arihiro, S | 1 |
| Saruta, M | 1 |
| Chen, J | 1 |
| Li, X | 1 |
| Liu, Y | 1 |
| Su, T | 1 |
| Lin, C | 1 |
| Shao, L | 1 |
| Li, L | 1 |
| Li, W | 1 |
| Niu, G | 1 |
| Yu, J | 1 |
| Liu, L | 1 |
| Li, M | 1 |
| Yu, X | 1 |
| Wang, Q | 1 |
| Kawczyk-Krupka, A | 1 |
| Czuba, ZP | 1 |
| Kwiatek, B | 1 |
| Kwiatek, S | 1 |
| Krupka, M | 1 |
| Sieroń, K | 1 |
| Harada, K | 1 |
| Harada, Y | 2 |
| Beika, M | 1 |
| Koizumi, N | 1 |
| Inoue, K | 2 |
| Murayama, Y | 3 |
| Kuriu, Y | 3 |
| Nakanishi, M | 3 |
| Minamikawa, T | 2 |
| Yamaoka, Y | 1 |
| Dai, P | 1 |
| Yanagisawa, A | 2 |
| Otsuji, E | 4 |
| Takamatsu, T | 2 |
| Inoue, Y | 1 |
| Tanaka, R | 1 |
| Komeda, K | 1 |
| Hirokawa, F | 1 |
| Hayashi, M | 1 |
| Uchiyama, K | 1 |
| Kondo, Y | 1 |
| Konishi, H | 2 |
| Morimura, R | 2 |
| Komatsu, S | 2 |
| Shiozaki, A | 2 |
| Ikoma, H | 2 |
| Kubota, T | 1 |
| Ichikawa, D | 2 |
| Fujiwara, H | 2 |
| Okamoto, K | 2 |
| Sakakura, C | 1 |
| Takahashi, K | 2 |
| Nakajima, M | 1 |
| Nakamura, M | 1 |
| Nishikawa, J | 1 |
| Hamabe, K | 1 |
| Goto, A | 1 |
| Nishimura, J | 1 |
| Shibata, H | 1 |
| Nagao, M | 1 |
| Sasaki, S | 1 |
| Hashimoto, S | 1 |
| Okamoto, T | 1 |
| Sakaida, I | 1 |
| Woźniak, M | 1 |
| Duś-Szachniewicz, K | 1 |
| Ziółkowski, P | 1 |
| Kamada, Y | 1 |
| Ota, U | 1 |
| Arita, T | 1 |
| Kosuga, T | 1 |
| Tanaka, T | 1 |
| Matsuo, H | 1 |
| Kato, Y | 1 |
| Tanaka, H | 1 |
| Postiglione, I | 1 |
| Barra, F | 1 |
| Aloj, SM | 1 |
| Palumbo, G | 1 |
| Yang, SJ | 2 |
| Shieh, MJ | 2 |
| Lin, FH | 2 |
| Lou, PJ | 1 |
| Peng, CL | 1 |
| Wei, MF | 2 |
| Yao, CJ | 1 |
| Lai, PS | 1 |
| Young, TH | 1 |
| Tsai, KC | 1 |
| Tsai, HM | 1 |
| Wong, JM | 1 |
| Serpe, L | 1 |
| Canaparo, R | 1 |
| Berta, L | 1 |
| Bargoni, A | 1 |
| Zara, GP | 1 |
| Frairia, R | 1 |
| Endlicher, E | 2 |
| Gelbmann, CM | 1 |
| Knüchel, R | 2 |
| Fürst, A | 1 |
| Szeimies, RM | 2 |
| Gölder, SK | 1 |
| Schölmerich, J | 2 |
| Lottner, C | 1 |
| Messmann, H | 2 |
| Ochsenkühn, T | 1 |
| Tillack, C | 1 |
| Stepp, H | 1 |
| Diebold, J | 1 |
| Ott, SJ | 1 |
| Baumgartner, R | 1 |
| Brand, S | 1 |
| Göke, B | 1 |
| Sackmann, M | 1 |
| Regula, J | 1 |
| MacRobert, AJ | 1 |
| Gorchein, A | 1 |
| Buonaccorsi, GA | 1 |
| Thorpe, SM | 1 |
| Spencer, GM | 1 |
| Hatfield, AR | 1 |
| Bown, SG | 1 |
| Hauser, T | 1 |
| Kullmann, F | 1 |
| Bäumler, W | 1 |
| Keller, R | 1 |
| Fischbach, W | 1 |
| Moesta, KT | 1 |
| Ebert, B | 1 |
| Handke, T | 1 |
| Rinneberg, H | 1 |
| Schlag, PM | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| The Correlation of Surgical Colorectal Cancer Specimen Pathology With the Fluorescence of Photodynamic Diagnostics (PDD): a Clinical Pilot Study[NCT03272659] | Phase 2 | 0 participants (Actual) | Interventional | 2018-04-01 | Withdrawn (stopped due to Long process and due to strict deadline, project was stopped.) | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for aminolevulinic acid and Colorectal Neoplasms
| Article | Year |
|---|---|
Fluorescence as a concept in colorectal lymph node diagnosis.
Topics: Aminolevulinic Acid; Colorectal Neoplasms; Dihematoporphyrin Ether; Fluorescent Dyes; Heme; Humans; | 2000 |
1 trial available for aminolevulinic acid and Colorectal Neoplasms
| Article | Year |
|---|---|
Photosensitisation and photodynamic therapy of oesophageal, duodenal, and colorectal tumours using 5 aminolaevulinic acid induced protoporphyrin IX--a pilot study.
Topics: Adult; Aged; Aged, 80 and over; Aminolevulinic Acid; Colorectal Neoplasms; Duodenal Neoplasms; Esoph | 1995 |
19 other studies available for aminolevulinic acid and Colorectal Neoplasms
| Article | Year |
|---|---|
Metronomic photodynamic therapy with 5-aminolevulinic acid induces apoptosis and autophagy in human SW837 colorectal cancer cells.
Topics: Aminolevulinic Acid; Apoptosis; Autophagy; Caspases; Cell Line, Tumor; Colorectal Neoplasms; Humans; | 2019 |
Endoscopic visualization of cancer and dysplasia in patients with ulcerative colitis following sensitization with oral 5-aminolevulinic acid.
Topics: Aminolevulinic Acid; Biopsy; Colitis, Ulcerative; Colonoscopy; Colorectal Neoplasms; Endoscopy; Fema | 2020 |
Engineering a probiotic strain of Escherichia coli to induce the regression of colorectal cancer through production of 5-aminolevulinic acid.
Topics: Aminolevulinic Acid; Animals; Colorectal Neoplasms; Escherichia coli; Mice; Plasmids; Probiotics | 2021 |
The effect of ALA-PDT under normoxia and cobalt chloride (CoCl
Topics: Aminolevulinic Acid; Apoptosis; Cell Adhesion Molecules; Cell Count; Cell Line, Tumor; Cell Survival | 2017 |
Detection of lymph node metastases in human colorectal cancer by using 5-aminolevulinic acid-induced protoporphyrin IX fluorescence with spectral unmixing.
Topics: Adult; Aged; Aged, 80 and over; Aminolevulinic Acid; Colorectal Neoplasms; Female; Fluorescence; Hum | 2013 |
Fluorescence detection of malignant liver tumors using 5-aminolevulinic acid-mediated photodynamic diagnosis: principles, technique, and clinical experience.
Topics: Aged; Aminolevulinic Acid; Anastomotic Leak; Carcinoma, Hepatocellular; Color; Colorectal Neoplasms; | 2014 |
Fluorescent detection of peritoneal metastasis in human colorectal cancer using 5-aminolevulinic acid.
Topics: Adult; Aged; Aged, 80 and over; Aminolevulinic Acid; Animals; Colorectal Neoplasms; HT29 Cells; Huma | 2014 |
Preliminary study of photodynamic diagnosis using 5-aminolevulinic acid in gastric and colorectal tumors.
Topics: Administration, Oral; Aged; Aminolevulinic Acid; Capsules; Colectomy; Colonoscopes; Colonoscopy; Col | 2015 |
Insulin-Like Growth Factor-2 Is Induced Following 5-Aminolevulinic Acid-Mediated Photodynamic Therapy in SW620 Human Colon Cancer Cell Line.
Topics: Aminolevulinic Acid; Apoptosis; Cell Line, Tumor; Cell Proliferation; Colorectal Neoplasms; Humans; | 2015 |
Urinary 5-Aminolevulinic Acid Concentrations as a Potential Tumor Marker for Colorectal Cancer Screening and Recurrence.
Topics: Aminolevulinic Acid; Colorectal Neoplasms; Humans; Photochemotherapy; Photosensitizing Agents; Recur | 2016 |
Simplified and optimized multispectral imaging for 5-ALA-based fluorescence diagnosis of malignant lesions.
Topics: Aminolevulinic Acid; Biotransformation; Cell Line, Tumor; Collagen; Colorectal Neoplasms; Flavins; F | 2016 |
Photodynamic therapy with 5-aminolaevulinic acid and DNA damage: unravelling roles of p53 and ABCG2.
Topics: Aminolevulinic Acid; ATP Binding Cassette Transporter, Subfamily G, Member 2; Carcinoma, Non-Small-C | 2016 |
Colorectal cancer cell detection by 5-aminolaevulinic acid-loaded chitosan nano-particles.
Topics: Aminolevulinic Acid; Caco-2 Cells; Chitosan; Colorectal Neoplasms; Endoscopy; Escherichia coli; Huma | 2009 |
Folic acid-conjugated chitosan nanoparticles enhanced protoporphyrin IX accumulation in colorectal cancer cells.
Topics: Aminolevulinic Acid; Caco-2 Cells; Carrier Proteins; Cell Line, Tumor; Chitosan; Colorectal Neoplasm | 2010 |
High energy shock waves and 5-aminolevulinic for sonodynamic therapy: effects in a syngeneic model of colon cancer.
Topics: Aminolevulinic Acid; Animals; Apoptosis; bcl-Associated Death Protein; Blotting, Western; Cell Line, | 2011 |
Hexaminolevulinate-induced fluorescence endoscopy in patients with rectal adenoma and cancer: a pilot study.
Topics: Adenoma; Aged; Aged, 80 and over; Aminolevulinic Acid; Biopsy; Carcinoma in Situ; Cell Transformatio | 2004 |
Low frequency of colorectal dysplasia in patients with long-standing inflammatory bowel disease colitis: detection by fluorescence endoscopy.
Topics: Administration, Oral; Adult; Aged; Aminolevulinic Acid; Biopsy; Colitis; Colonoscopy; Colorectal Neo | 2006 |
[Photodynamic diagnosis of gastrointestinal precancerous lesions after sensitization with 5-aminolevulinic acid. A pilot study].
Topics: Adenoma; Adult; Aged; Aminolevulinic Acid; Barrett Esophagus; Colitis, Ulcerative; Colorectal Neopla | 1998 |
[Endoscopic fluorescence detection of dysplasia in patients with Barrett's esophagus, ulcerative colitis or colorectal adenomas].
Topics: Adenomatous Polyps; Aminolevulinic Acid; Barrett Esophagus; Biopsy; Colitis, Ulcerative; Colorectal | 1999 |