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aminolevulinic acid and Chronic Disease

aminolevulinic acid has been researched along with Chronic Disease in 29 studies

Aminolevulinic Acid: A compound produced from succinyl-CoA and GLYCINE as an intermediate in heme synthesis. It is used as a PHOTOCHEMOTHERAPY for actinic KERATOSIS.
5-aminolevulinic acid : The simplest delta-amino acid in which the hydrogens at the gamma position are replaced by an oxo group. It is metabolised to protoporphyrin IX, a photoactive compound which accumulates in the skin. Used (in the form of the hydrochloride salt)in combination with blue light illumination for the treatment of minimally to moderately thick actinic keratosis of the face or scalp.

Chronic Disease: Diseases which have one or more of the following characteristics: they are permanent, leave residual disability, are caused by nonreversible pathological alteration, require special training of the patient for rehabilitation, or may be expected to require a long period of supervision, observation, or care (Dictionary of Health Services Management, 2d ed). For epidemiological studies chronic disease often includes HEART DISEASES; STROKE; CANCER; and diabetes (DIABETES MELLITUS, TYPE 2).

Research Excerpts

ExcerptRelevanceReference
" Hexachlorobenzene porphyria in the rat provides a suitable experimental model of the stages of development of human chronic hepatic porphyria."7.65Hexachlorobenzene porphyria in rats as a model for human chronic hepatic porphyrias. ( Doss, M; Koss, G; Schermuly, E, 1976)
"The dynamics of conjugation of 14C-bilirubin injected intravenously during cholestasis is known from studies in rats and dogs."7.65Conjugation of non-erythroid bilirubin in chronic experimental cholestasis in the dog. ( Bergan, A; Gjelstad, N; Ostrem, T, 1975)
"Porphyrias are a group of eight rare inherited metabolic disorders of heme biosynthesis pathway."4.86Porphyrias at a glance: diagnosis and treatment. ( Brancaleoni, V; Cappellini, MD; Di Pierro, E; Graziadei, G; Tavazzi, D, 2010)
"Disturbances in the biosynthesis of porphyrins in erythrocytes were investigated in 50 patients with chronic nephritis after incubation with delta-aminolevulinic acid."3.66[Chronic nephritis--porphyrin biosynthesis and nephrogenic anemia]. ( Iwanov, E; Pisanets, M, 1983)
" Hexachlorobenzene porphyria in the rat provides a suitable experimental model of the stages of development of human chronic hepatic porphyria."3.65Hexachlorobenzene porphyria in rats as a model for human chronic hepatic porphyrias. ( Doss, M; Koss, G; Schermuly, E, 1976)
"The dynamics of conjugation of 14C-bilirubin injected intravenously during cholestasis is known from studies in rats and dogs."3.65Conjugation of non-erythroid bilirubin in chronic experimental cholestasis in the dog. ( Bergan, A; Gjelstad, N; Ostrem, T, 1975)
"Porphyrias are a group of eight rare inherited metabolic disorders of heme biosynthesis pathway."2.46Porphyrias at a glance: diagnosis and treatment. ( Brancaleoni, V; Cappellini, MD; Di Pierro, E; Graziadei, G; Tavazzi, D, 2010)
"Acne vulgaris is a common dermatological disorder."1.37Successful treatment of refractory facial acne using repeat short-cycle ALA-PDT: Case study. ( Ding, HL; Huang, Z; Wang, HW; Wang, XL, 2011)
"Cutaneous verrucous carcinoma is a low-grade and well-differentiated variant of squamous cell carcinoma."1.34Photodynamic therapy for cutaneous verrucous carcinoma. ( Nikkels, AF; Piérard, GE; Quatresooz, P; Thirion, L, 2007)
" The folliculitis had occurred in areas of acne-prone skin of the patients, mainly after long-term administration of antibiotics."1.34Topical methyl aminolevulinate photodynamic therapy for the treatment of folliculitis. ( Horn, M; Wolf, P, 2007)

Research

Studies (29)

TimeframeStudies, this research(%)All Research%
pre-19908 (27.59)18.7374
1990's5 (17.24)18.2507
2000's10 (34.48)29.6817
2010's6 (20.69)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Rakesh, N1
Clint, JB1
Reddy, SS1
Nagi, R1
Chauhan, P1
Sharma, S1
Sharma, P1
Kaur, A1
Shetty, B1
Ashwini, S1
Pavan Kumar, T1
Vidya, GS1
Liu, Y1
Ma, Y1
Xiang, LH1
Patel, D1
Alhawaj, R1
Wolin, MS1
Lei, X1
Liu, B1
Huang, Z2
Wu, J1
Sotiriou, E1
Apalla, Z1
Maliamani, F1
Ioannides, D1
Cappellini, MD1
Brancaleoni, V1
Graziadei, G1
Tavazzi, D1
Di Pierro, E1
Ding, HL1
Wang, XL1
Wang, HW1
Escudero, A1
Nagore, E1
Sevila, A1
Sanmartin, O1
Botella, R1
Guillen, C1
Endlicher, E1
Rümmele, P1
Hausmann, F1
Rath, HC1
Knüchel, R1
Krieg, RC1
Schölmerich, J2
Messmann, H2
Radakovic-Fijan, S2
Blecha-Thalhammer, U1
Schleyer, V2
Szeimies, RM2
Zwingers, T2
Hönigsmann, H1
Tanew, A2
Yim, YC1
Lee, ES1
Chung, PS1
Rhee, CK1
Karrer, S1
Landthaler, M1
Clayton, TH1
Harrison, PV1
Nikkels, AF1
Thirion, L1
Quatresooz, P1
Piérard, GE1
Horn, M1
Wolf, P1
Lopez-Navarro, N1
Alcaraz, I1
Bosch, RJ1
Tejera, A1
Herrera, E1
Iwanov, E1
Pisanets, M1
Sada-Cieślar, M1
Mazur, B1
Buszman, Z1
Cieślar, G1
Boehncke, WH1
Sterry, W1
Kaufmann, R1
Soldatovic, D1
Vujanovic, D1
Matovic, V1
Plamenac, Z1
Collins, P1
Robinson, DJ1
Stringer, MR1
Stables, GI1
Sheehan-Dare, RA1
Kullmann, F1
Wild, T1
Knüchel-Clarke, R1
Rüschoff, J1
Gross, V1
Holstege, A1
Petryka, ZJ1
Doss, M2
Schermuly, E1
Koss, G1
Schwanitz, G1
Gebhart, E1
Rott, HD1
Schaller, KH1
Essing, HG1
Lauer, O1
Prestele, H1
Bergan, A1
Ostrem, T1
Gjelstad, N1
Dhawan, M1
Flora, SJ1
Tandon, SK1
Bartlett, RS1
Rousseau, JE1
Frier, HI1
Hall, RC1

Clinical Trials (2)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Oral Lichen Planus Photodynamic Treatment[NCT05127083]60 participants (Actual)Interventional2018-06-04Completed
Efficacy and Safety of Methylene Blue -Mediated Photodynamic Therapy for Diabetic Lower Limb Ulcer : a Randomized Controlled Study[NCT03222544]60 participants (Anticipated)Interventional2019-04-29Recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

3 reviews available for aminolevulinic acid and Chronic Disease

ArticleYear
Successful treatment of recalcitrant dissecting cellulitis of the scalp with ALA-PDT: case report and literature review.
    Photodiagnosis and photodynamic therapy, 2013, Volume: 10, Issue:4

    Topics: Administration, Topical; Adult; Aminolevulinic Acid; Cellulitis; Chronic Disease; Female; Humans; Ph

2013
Porphyrias at a glance: diagnosis and treatment.
    Internal and emergency medicine, 2010, Volume: 5 Suppl 1

    Topics: Acute Disease; Aminolevulinic Acid; Chronic Disease; Genetic Testing; Heme; Humans; Porphobilinogen;

2010
[Pathobiochemistry of porphyrias].
    Medizinische Klinik, 1977, Sep-23, Volume: 72, Issue:38

    Topics: Acute Disease; Aminolevulinic Acid; Catalase; Chronic Disease; Cytochrome P-450 Enzyme System; Heme;

1977

Trials

4 trials available for aminolevulinic acid and Chronic Disease

ArticleYear
A clinical study of photodynamic therapy for chronic skin ulcers in lower limbs infected with Pseudomonas aeruginosa.
    Archives of dermatological research, 2015, Volume: 307, Issue:1

    Topics: Adult; Aged; Aminolevulinic Acid; Bacterial Load; China; Chronic Disease; Colony Count, Microbial; F

2015
Topical aminolaevulinic acid-based photodynamic therapy as a treatment option for psoriasis? Results of a randomized, observer-blinded study.
    The British journal of dermatology, 2005, Volume: 152, Issue:2

    Topics: Adult; Aged; Aged, 80 and over; Aminolevulinic Acid; Chronic Disease; Female; Humans; Male; Middle A

2005
Disappointing results and low tolerability of photodynamic therapy with topical 5-aminolaevulinic acid in psoriasis. A randomized, double-blind phase I/II study.
    Journal of the European Academy of Dermatology and Venereology : JEADV, 2006, Volume: 20, Issue:7

    Topics: Administration, Topical; Adult; Aminolevulinic Acid; Chronic Disease; Double-Blind Method; Female; H

2006
The variable response of plaque psoriasis after a single treatment with topical 5-aminolaevulinic acid photodynamic therapy.
    The British journal of dermatology, 1997, Volume: 137, Issue:5

    Topics: Aminolevulinic Acid; Chronic Disease; Dose-Response Relationship, Radiation; Humans; Photochemothera

1997

Other Studies

22 other studies available for aminolevulinic acid and Chronic Disease

ArticleYear
Clinical evaluation of photodynamic therapy for the treatment of refractory oral Lichen planus - A case series.
    Photodiagnosis and photodynamic therapy, 2018, Volume: 24

    Topics: Adult; Aged; Aminolevulinic Acid; Chronic Disease; Female; Humans; Lichen Planus, Oral; Male; Middle

2018
Exposure of mice to chronic hypoxia attenuates pulmonary arterial contractile responses to acute hypoxia by increases in extracellular hydrogen peroxide.
    American journal of physiology. Regulatory, integrative and comparative physiology, 2014, Aug-15, Volume: 307, Issue:4

    Topics: Acute Disease; Aminolevulinic Acid; Animals; Antihypertensive Agents; Aorta; Cell Adhesion Molecules

2014
Treatment of recalcitrant hidradenitis suppurativa with photodynamic therapy: report of five cases.
    Clinical and experimental dermatology, 2009, Volume: 34, Issue:7

    Topics: Adult; Aminolevulinic Acid; Chronic Disease; Female; Hidradenitis Suppurativa; Humans; Male; Photoch

2009
Successful treatment of refractory facial acne using repeat short-cycle ALA-PDT: Case study.
    Photodiagnosis and photodynamic therapy, 2011, Volume: 8, Issue:4

    Topics: Acne Vulgaris; Aminolevulinic Acid; Chronic Disease; Facial Dermatoses; Humans; Male; Photochemother

2011
Chronic X-ray dermatitis treated by topical 5-aminolaevulinic acid-photodynamic therapy.
    The British journal of dermatology, 2002, Volume: 147, Issue:2

    Topics: Aged; Aminolevulinic Acid; Chronic Disease; Dermatitis, Occupational; Hand Dermatoses; Humans; Male;

2002
Detection of dysplastic lesions by fluorescence in a model of chronic colitis in rats after local application of 5-aminolevulinic acid and its esterified derivatives.
    Photochemistry and photobiology, 2004, Volume: 79, Issue:2

    Topics: Administration, Topical; Aminolevulinic Acid; Animals; Biopsy; Chronic Disease; Colitis; Colon; Dise

2004
Recalcitrant palmoplantar pustular psoriasis successfully treated with topical 5-aminolaevulinic acid photodynamic therapy.
    Clinical and experimental dermatology, 2005, Volume: 30, Issue:6

    Topics: Adult; Aminolevulinic Acid; Chronic Disease; Dose-Response Relationship, Radiation; Female; Humans;

2005
Photodynamic therapy for infected leg ulcers.
    The British journal of dermatology, 2007, Volume: 156, Issue:2

    Topics: Aged; Aminolevulinic Acid; Chronic Disease; Female; Humans; Leg Ulcer; Methicillin Resistance; Photo

2007
Photodynamic therapy for cutaneous verrucous carcinoma.
    Journal of the American Academy of Dermatology, 2007, Volume: 57, Issue:3

    Topics: Aged, 80 and over; Aminolevulinic Acid; Carcinoma, Verrucous; Chronic Disease; Drug Administration S

2007
Topical methyl aminolevulinate photodynamic therapy for the treatment of folliculitis.
    Photodermatology, photoimmunology & photomedicine, 2007, Volume: 23, Issue:4

    Topics: Administration, Topical; Adult; Aminolevulinic Acid; Chronic Disease; Folliculitis; Humans; Male; Ph

2007
Keratosis lichenoides chronica: response to photodynamic therapy.
    The Journal of dermatological treatment, 2008, Volume: 19, Issue:2

    Topics: Aminolevulinic Acid; Chronic Disease; Female; Humans; Keratosis; Lichenoid Eruptions; Middle Aged; P

2008
[Chronic nephritis--porphyrin biosynthesis and nephrogenic anemia].
    Zeitschrift fur Urologie und Nephrologie, 1983, Volume: 76, Issue:11

    Topics: Adolescent; Adult; Aminolevulinic Acid; Anemia; Chronic Disease; Erythrocytes; Female; Humans; Male;

1983
[Lead poisoning in children from the industrial region of Silesia--markers of chronic intoxication].
    Wiadomosci lekarskie (Warsaw, Poland : 1960), 1994, Volume: 47, Issue:15-16

    Topics: Adolescent; Aminolevulinic Acid; Biomarkers; Case-Control Studies; Child; Chronic Disease; Environme

1994
Treatment of psoriasis by topical photodynamic therapy with polychromatic light.
    Lancet (London, England), 1994, Mar-26, Volume: 343, Issue:8900

    Topics: Administration, Topical; Aminolevulinic Acid; Anthralin; Chronic Disease; Follow-Up Studies; Humans;

1994
Compared effects of high oral Mg supplements and of EDTA chelating agent on chronic lead intoxication in rabbits.
    Magnesium research, 1997, Volume: 10, Issue:2

    Topics: Administration, Oral; Aminolevulinic Acid; Analysis of Variance; Animals; Chelating Agents; Chronic

1997
Detection of dysplastic lesions by fluorescence in a model of colitis in rats after previous photosensitization with 5-aminolaevulinic acid.
    Endoscopy, 1998, Volume: 30, Issue:4

    Topics: Acute Disease; Aminolevulinic Acid; Animals; Chi-Square Distribution; Chronic Disease; Colitis; Colo

1998
Enzyme abnormalities in the porphyrias.
    Lancet (London, England), 1977, Nov-12, Volume: 2, Issue:8046

    Topics: Acute Disease; Aminolevulinic Acid; Chronic Disease; Humans; Hydroxymethylbilane Synthase; Porphyria

1977
Hexachlorobenzene porphyria in rats as a model for human chronic hepatic porphyrias.
    Annals of clinical research, 1976, Volume: 8 Suppl 17

    Topics: Aminolevulinic Acid; Animals; Chlorobenzenes; Chronic Disease; Coproporphyrins; Disease Models, Anim

1976
[Chromosome investigations in subjects with occupational lead exposure (author's transl)].
    Deutsche medizinische Wochenschrift (1946), 1975, May-02, Volume: 100, Issue:18

    Topics: Aminolevulinic Acid; Chromosome Aberrations; Chronic Disease; Culture Techniques; Humans; Lead; Lead

1975
Conjugation of non-erythroid bilirubin in chronic experimental cholestasis in the dog.
    Scandinavian journal of gastroenterology, 1975, Volume: 10, Issue:6

    Topics: Aminolevulinic Acid; Animals; Bilirubin; Cholestasis; Chronic Disease; Dogs; Liver; Lymph

1975
Preventive and therapeutic role of vitamin E in chronic plumbism.
    Biomedical and environmental sciences : BES, 1989, Volume: 2, Issue:4

    Topics: Aminolevulinic Acid; Animals; Biogenic Amines; Brain Chemistry; Chronic Disease; Lead; Lead Poisonin

1989
Effect of vitamin E on delta-aminolevulinic acid dehydratase activity in weanling rabbits with chronic plumbism.
    The Journal of nutrition, 1974, Volume: 104, Issue:12

    Topics: 5-Aminolevulinate Synthetase; Aminolevulinic Acid; Animals; Chronic Disease; Dose-Response Relations

1974