aminolevulinic acid has been researched along with Chemical and Drug Induced Liver Injury in 11 studies
Aminolevulinic Acid: A compound produced from succinyl-CoA and GLYCINE as an intermediate in heme synthesis. It is used as a PHOTOCHEMOTHERAPY for actinic KERATOSIS.
5-aminolevulinic acid : The simplest delta-amino acid in which the hydrogens at the gamma position are replaced by an oxo group. It is metabolised to protoporphyrin IX, a photoactive compound which accumulates in the skin. Used (in the form of the hydrochloride salt)in combination with blue light illumination for the treatment of minimally to moderately thick actinic keratosis of the face or scalp.
Chemical and Drug Induced Liver Injury: A spectrum of clinical liver diseases ranging from mild biochemical abnormalities to ACUTE LIVER FAILURE, caused by drugs, drug metabolites, herbal and dietary supplements and chemicals from the environment.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The ability of 3,5-diethoxycarbonyl-1,4-dihydrocollidine (DDC), 3,5-diethoxycarbonyl-4-ethyl-1,4-dihydro-2,6-dimethylpyridine (EDDC) and griseofulvin to induce porphyria in primary cultures of mouse hepatocytes has been examined." | 3.68 | Inhibition of ferrochelatase and accumulation of porphyrins in mouse hepatocyte cultures exposed to porphyrinogenic chemicals. ( Brady, AM; Lock, EA, 1992) |
| "Numerous drugs and environmental chemicals are capable of influencing the clinical expression of human hepatic porphyria primarily by interfering with the orderly regulation of heme synthesis in the liver." | 3.66 | Environmental and drug factors in hepatic porphyria. ( Bickers, DR, 1982) |
| " Hypotension and alteration of liver functions have been reported as potential adverse effects." | 2.78 | Risk factors for developing oral 5-aminolevulinic acid-induced side effects in patients undergoing fluorescence guided resection. ( Chung, IW; Eljamel, S, 2013) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (27.27) | 18.7374 |
| 1990's | 2 (18.18) | 18.2507 |
| 2000's | 2 (18.18) | 29.6817 |
| 2010's | 4 (36.36) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Liu, Z | 1 |
| Shi, Q | 1 |
| Ding, D | 1 |
| Kelly, R | 1 |
| Fang, H | 1 |
| Tong, W | 1 |
| Miyake, M | 1 |
| Nakai, Y | 1 |
| Hori, S | 1 |
| Morizawa, Y | 1 |
| Hirao, Y | 1 |
| Fujimoto, K | 1 |
| Chung, IW | 1 |
| Eljamel, S | 1 |
| Guyon, L | 1 |
| Farine, MO | 1 |
| Lesage, JC | 1 |
| Gevaert, AM | 1 |
| Simonin, S | 1 |
| Schmitt, C | 1 |
| Collinet, P | 1 |
| Mordon, S | 1 |
| Bickers, DR | 1 |
| Sinclair, PR | 1 |
| Gorman, N | 1 |
| Walton, HS | 1 |
| Bement, WJ | 1 |
| Dalton, TP | 1 |
| Sinclair, JF | 1 |
| Smith, AG | 1 |
| Nebert, DW | 1 |
| Szymańska, JA | 1 |
| Piotrowski, JK | 1 |
| Brady, AM | 1 |
| Lock, EA | 1 |
| Deam, S | 1 |
| Elder, GH | 1 |
| Skoglund, LA | 1 |
| Ingebrigtsen, K | 1 |
| Nafstad, I | 1 |
| Aalen, O | 1 |
| Wehmeier, A | 1 |
| Fischer, JT | 1 |
| Goerz, G | 1 |
| Schneider, W | 1 |
2 trials available for aminolevulinic acid and Chemical and Drug Induced Liver Injury
| Article | Year |
|---|---|
Transient liver toxicity as a result of the oral administration of 5-aminolevulinic acid for photodynamic diagnosis in patients with bladder cancer.
Topics: Administration, Oral; Age Factors; Aged; Aminolevulinic Acid; Chemical and Drug Induced Liver Injury | 2019 |
Risk factors for developing oral 5-aminolevulinic acid-induced side effects in patients undergoing fluorescence guided resection.
Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Aminolevulinic Acid; Chemical and Drug Induced | 2013 |
9 other studies available for aminolevulinic acid and Chemical and Drug Induced Liver Injury
| Article | Year |
|---|---|
Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).
Topics: Animals; Anti-Infective Agents; Anti-Inflammatory Agents; Chemical and Drug Induced Liver Injury; Da | 2011 |
Photodynamic therapy of ovarian cancer peritoneal metastasis with hexaminolevulinate: a toxicity study.
Topics: Aminolevulinic Acid; Animals; Cell Line, Tumor; Chemical and Drug Induced Liver Injury; Dose-Respons | 2014 |
Environmental and drug factors in hepatic porphyria.
Topics: 5-Aminolevulinate Synthetase; Allyl Compounds; Aminolevulinic Acid; Barbiturates; Chemical and Drug | 1982 |
CYP1A2 is essential in murine uroporphyria caused by hexachlorobenzene and iron.
Topics: Aminolevulinic Acid; Animals; Antibodies; Blotting, Western; Chemical and Drug Induced Liver Injury; | 2000 |
Hepatotoxicity of monobromobenzene and hexabromobenzene: effects of repeated dosage in rats.
Topics: 5-Aminolevulinate Synthetase; Aminolevulinic Acid; Animals; Bromobenzenes; Chemical and Drug Induced | 2000 |
Inhibition of ferrochelatase and accumulation of porphyrins in mouse hepatocyte cultures exposed to porphyrinogenic chemicals.
Topics: Aminolevulinic Acid; Animals; Cells, Cultured; Chemical and Drug Induced Liver Injury; Dicarbethoxyd | 1992 |
Uroporphyria produced in mice by iron and 5-aminolevulinic acid.
Topics: Administration, Oral; Aminolevulinic Acid; Animals; Chemical and Drug Induced Liver Injury; Cytochro | 1991 |
In vivo studies on toxic effects of concurrent administration of paracetamol and its N-acetyl-DL-methionine ester (SUR 2647 combination).
Topics: Acetaminophen; Alanine Transaminase; Aminolevulinic Acid; Animals; Chemical and Drug Induced Liver I | 1988 |
Polychemotherapy of acute myelogenous leukemia in a patient with acute intermittent porphyria.
Topics: Acute Disease; Adult; Aminolevulinic Acid; Antineoplastic Combined Chemotherapy Protocols; Chemical | 1987 |