aminolevulinic acid has been researched along with Cervix Dysplasia in 43 studies
Aminolevulinic Acid: A compound produced from succinyl-CoA and GLYCINE as an intermediate in heme synthesis. It is used as a PHOTOCHEMOTHERAPY for actinic KERATOSIS.
5-aminolevulinic acid : The simplest delta-amino acid in which the hydrogens at the gamma position are replaced by an oxo group. It is metabolised to protoporphyrin IX, a photoactive compound which accumulates in the skin. Used (in the form of the hydrochloride salt)in combination with blue light illumination for the treatment of minimally to moderately thick actinic keratosis of the face or scalp.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To evaluate the efficacy of 5-aminolevulinic acid photodynamic therapy (ALA-PDT) in the treatment of high-grade squamous intraepithelial lesions of the cervix (HSIL)." | 8.12 | Topical 5-aminolevulinic acid photodynamic therapy for cervical high-grade squamous intraepithelial lesions. ( Chen, J; Hu, Y; Li, Y; Ma, L; Teng, Y; Xu, Y, 2022) |
| "Patients with cervical LSIL and HPV infection were divided into 3 treatment groups based on their own choice." | 7.30 | The effect of aminolevulinic acid hydrochloride topical powder photodynamic therapy versus nocardia rubra cell wall skeleton and observers group in the treatment of cervical low-grade squamous intraepithelial lesions with human papillomavirus infection: A ( Gong, H; Jiang, S; Nan, X; Pan, X; Tang, L; Zhang, J, 2023) |
| "Cervical high-grade squamous intraepithelial lesions (HSIL), as pre-cancerous lesions, have a 5% chance of progressing to invasive cancer." | 5.72 | The effect of high-risk HPV E6/E7 mRNA on the efficacy of topical photodynamic therapy with 5-aminolevulinic acid for cervical high-grade squamous intraepithelial lesions. ( Cao, L; Qin, L; Shen, Y; Su, Y; Tang, Y; Wang, B; Wang, L; Zhang, L; Zhang, M; Zhang, T; Zhang, Y; Zhou, Y, 2022) |
| "High-risk HPV infection is the main cause of cervical cancer and pre-cancerous lesions." | 5.62 | The effect of local photodynamic therapy with 5-aminolevulinic acid for the treatment of cervical low-grade squamous intraepithelial lesions with high-risk HPV infection: A retrospective study. ( Cheng, M; Di, W; Gu, L; Hong, Z; Qiu, L, 2021) |
| "Progression to high-grade squamous intraepithelial lesion warrants intervention." | 5.62 | The effect of local photodynamic therapy with 5-aminolevulinic acid for the treatment of cervical low-grade squamous intraepithelial lesions with high-risk HPV infection: A retrospective study. ( Cheng, M; Di, W; Gu, L; Hong, Z; Qiu, L, 2021) |
| "80 patients with CINI and HR-HPV infection were selected for the study." | 5.56 | Treatment of HPV Infection-Associated Low Grade Cervical Intraepithelial Neoplasia with 5-Aminolevulinic Acid-Mediated Photodynamic Therapy. ( Cai, Q; Li, D; Lin, L; Shi, L; Xu, Y; Zhang, F, 2020) |
| "To evaluate the efficacy of 5-aminolevulinic acid photodynamic therapy (ALA-PDT) in the treatment of high-grade squamous intraepithelial lesions of the cervix (HSIL)." | 4.12 | Topical 5-aminolevulinic acid photodynamic therapy for cervical high-grade squamous intraepithelial lesions. ( Chen, J; Hu, Y; Li, Y; Ma, L; Teng, Y; Xu, Y, 2022) |
| "Patients with cervical LSIL and HPV infection were divided into 3 treatment groups based on their own choice." | 3.30 | The effect of aminolevulinic acid hydrochloride topical powder photodynamic therapy versus nocardia rubra cell wall skeleton and observers group in the treatment of cervical low-grade squamous intraepithelial lesions with human papillomavirus infection: A ( Gong, H; Jiang, S; Nan, X; Pan, X; Tang, L; Zhang, J, 2023) |
| " Twenty-six patients (37%) reported 44 adverse events (AEs), of which 40 were mild or moderate." | 2.79 | Efficacy and safety of hexaminolevulinate photodynamic therapy in patients with low-grade cervical intraepithelial neoplasia. ( Ardaens, K; Collinet, P; Dannecker, C; Gallwas, J; Hillemanns, P; Luyten, A; Petry, KU; Soergel, P, 2014) |
| "Cervical high-grade squamous intraepithelial lesions (HSIL), as pre-cancerous lesions, have a 5% chance of progressing to invasive cancer." | 1.72 | The effect of high-risk HPV E6/E7 mRNA on the efficacy of topical photodynamic therapy with 5-aminolevulinic acid for cervical high-grade squamous intraepithelial lesions. ( Cao, L; Qin, L; Shen, Y; Su, Y; Tang, Y; Wang, B; Wang, L; Zhang, L; Zhang, M; Zhang, T; Zhang, Y; Zhou, Y, 2022) |
| "5-Aminolevulinic acid (5-ALA) is a porphyrin-based photosensitizer and has been used for photodynamic therapy of cervical intraepithelial neoplasia (CIN)." | 1.62 | Photodetection and Safety of 5-Aminolevulinic Acid-Induced Porphyrin in Patients With Cervical Intraepithelial Neoplasia. ( Bai, W; Cao, F; Chen, R; Cui, Y; Dong, Y; Shi, Y; Tao, J; Xu, J; Zhao, J; Zhao, X, 2021) |
| " Three adverse events were considered related to the drug; however, these had no significant correlation with the drug concentration or application time." | 1.62 | Photodetection and Safety of 5-Aminolevulinic Acid-Induced Porphyrin in Patients With Cervical Intraepithelial Neoplasia. ( Bai, W; Cao, F; Chen, R; Cui, Y; Dong, Y; Shi, Y; Tao, J; Xu, J; Zhao, J; Zhao, X, 2021) |
| "5-ALA at 10%-30% concentration is safe in patients with CIN." | 1.62 | Photodetection and Safety of 5-Aminolevulinic Acid-Induced Porphyrin in Patients With Cervical Intraepithelial Neoplasia. ( Bai, W; Cao, F; Chen, R; Cui, Y; Dong, Y; Shi, Y; Tao, J; Xu, J; Zhao, J; Zhao, X, 2021) |
| "High-risk HPV infection is the main cause of cervical cancer and pre-cancerous lesions." | 1.62 | The effect of local photodynamic therapy with 5-aminolevulinic acid for the treatment of cervical low-grade squamous intraepithelial lesions with high-risk HPV infection: A retrospective study. ( Cheng, M; Di, W; Gu, L; Hong, Z; Qiu, L, 2021) |
| "Progression to high-grade squamous intraepithelial lesion warrants intervention." | 1.62 | The effect of local photodynamic therapy with 5-aminolevulinic acid for the treatment of cervical low-grade squamous intraepithelial lesions with high-risk HPV infection: A retrospective study. ( Cheng, M; Di, W; Gu, L; Hong, Z; Qiu, L, 2021) |
| " Affecting factors of the efficacy of PDT and adverse events were also assessed during treatment." | 1.62 | Efficacy and safety of photodynamic therapy mediated by 5-aminolevulinic acid for the treatment of cervical intraepithelial neoplasia 2: A single-center, prospective, cohort study. ( Gao, X; Geng, L; Guo, H; Han, Q; Li, Y; Ma, L; Wang, Y; Wu, Z; You, K, 2021) |
| "PDT can be a safe and efficient treatment for CIN2." | 1.62 | Efficacy and safety of photodynamic therapy mediated by 5-aminolevulinic acid for the treatment of cervical intraepithelial neoplasia 2: A single-center, prospective, cohort study. ( Gao, X; Geng, L; Guo, H; Han, Q; Li, Y; Ma, L; Wang, Y; Wu, Z; You, K, 2021) |
| "80 patients with CINI and HR-HPV infection were selected for the study." | 1.56 | Treatment of HPV Infection-Associated Low Grade Cervical Intraepithelial Neoplasia with 5-Aminolevulinic Acid-Mediated Photodynamic Therapy. ( Cai, Q; Li, D; Lin, L; Shi, L; Xu, Y; Zhang, F, 2020) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 4 (9.30) | 18.2507 |
| 2000's | 11 (25.58) | 29.6817 |
| 2010's | 11 (25.58) | 24.3611 |
| 2020's | 17 (39.53) | 2.80 |
| Authors | Studies |
|---|---|
| Su, Y | 4 |
| Zhang, Y | 4 |
| Tong, Y | 1 |
| Zhang, L | 3 |
| Li, P | 1 |
| Zhang, H | 1 |
| Zhang, X | 1 |
| Tang, Y | 3 |
| Qin, L | 3 |
| Shen, Y | 3 |
| Wang, B | 4 |
| Zhou, Y | 4 |
| Cao, L | 3 |
| Zhang, M | 5 |
| Zhang, T | 4 |
| Cai, H | 2 |
| Che, Y | 2 |
| Sun, X | 1 |
| Yu, X | 1 |
| Yu, F | 1 |
| Hou, F | 1 |
| Wang, Y | 3 |
| Ma, T | 2 |
| Wang, L | 2 |
| Liu, X | 1 |
| Zhang, J | 2 |
| Jia, L | 1 |
| Hu, Y | 1 |
| Li, Y | 2 |
| Xu, Y | 2 |
| Teng, Y | 1 |
| Chen, J | 2 |
| Ma, L | 2 |
| Zhang, C | 1 |
| Zhou, M | 1 |
| Yuan, S | 1 |
| Hisamatsu, Y | 1 |
| Kita, M | 1 |
| Yokoe, T | 1 |
| Butsuhara, Y | 1 |
| Okada, H | 1 |
| Jiang, S | 1 |
| Nan, X | 1 |
| Pan, X | 1 |
| Tang, L | 1 |
| Gong, H | 1 |
| Wu, A | 1 |
| Niu, J | 1 |
| Hong, Z | 2 |
| Gu, L | 2 |
| Huang, Y | 1 |
| Qiu, L | 2 |
| Wang, C | 1 |
| Yin, G | 1 |
| de Castro, CA | 1 |
| Lombardi, W | 1 |
| Stringasci, MD | 1 |
| Bagnato, VS | 1 |
| Inada, NM | 1 |
| Li, D | 1 |
| Zhang, F | 1 |
| Shi, L | 1 |
| Lin, L | 1 |
| Cai, Q | 1 |
| Mizuno, M | 1 |
| Mitsui, H | 1 |
| Kajiyama, H | 1 |
| Teshigawara, T | 1 |
| Inoue, K | 1 |
| Takahashi, K | 1 |
| Ishii, T | 1 |
| Ishizuka, M | 1 |
| Nakajima, M | 1 |
| Kikkawa, F | 1 |
| Xu, J | 2 |
| Zhao, J | 1 |
| Dong, Y | 1 |
| Zhao, X | 1 |
| Chen, R | 1 |
| Shi, Y | 1 |
| Tao, J | 1 |
| Cao, F | 1 |
| Cui, Y | 1 |
| Bai, W | 1 |
| Cheng, M | 1 |
| Di, W | 1 |
| Gao, X | 1 |
| Geng, L | 1 |
| You, K | 1 |
| Wu, Z | 1 |
| Han, Q | 1 |
| Guo, H | 1 |
| Maldonado Alvarado, E | 1 |
| Osorio Peralta, MO | 1 |
| Moreno Vázquez, A | 1 |
| Martínez Guzmán, LA | 1 |
| Melo Petrone, ME | 1 |
| Enriquez Mar, ZI | 1 |
| Jovel Galdamez, DE | 1 |
| Carrión Solana, B | 1 |
| Balderas Martínez, G | 1 |
| Parra, E | 1 |
| Castellanos Oliveros, RI | 1 |
| Bello Leiva, RL | 1 |
| Espinosa Montesinos, A | 1 |
| Barrera Mendoza, C | 1 |
| Medina García, SE | 1 |
| Ramón Gallegos, E | 1 |
| Hillemanns, P | 14 |
| Petry, KU | 2 |
| Soergel, P | 7 |
| Collinet, P | 1 |
| Ardaens, K | 1 |
| Gallwas, J | 1 |
| Luyten, A | 1 |
| Dannecker, C | 2 |
| Vansevičiūtė, R | 2 |
| Venius, J | 2 |
| Letautienė, S | 2 |
| Garcia, F | 1 |
| Dvorak, V | 1 |
| Sadovsky, O | 1 |
| Iversen, OE | 2 |
| Einstein, MH | 2 |
| Žukovskaja, O | 1 |
| Kanopienė, D | 1 |
| Rotomskis, R | 1 |
| Hass, R | 1 |
| Jacobs, R | 1 |
| Kaufmann, AM | 1 |
| Wang, X | 3 |
| Stepp, H | 5 |
| Hertel, H | 3 |
| Zawislak, A | 1 |
| Donnelly, RF | 1 |
| McCluggage, WG | 1 |
| Price, JH | 1 |
| McClelland, HR | 1 |
| Woolfson, AD | 1 |
| Dobbs, S | 1 |
| Maxwell, P | 1 |
| McCarron, PA | 1 |
| Wang, J | 1 |
| He, Q | 1 |
| Xiang, L | 1 |
| Huang, X | 1 |
| Ding, G | 1 |
| Xu, S | 1 |
| Loehr-Schulz, R | 1 |
| Hillemanns, M | 3 |
| Landwehr, S | 1 |
| Makowski, L | 2 |
| Makowski, E | 1 |
| Schippert, C | 1 |
| Dahl, GF | 1 |
| Onsrud, M | 1 |
| Keefe, KA | 2 |
| Tadir, Y | 2 |
| Tromberg, B | 1 |
| Berns, M | 1 |
| Osann, K | 1 |
| Hashad, R | 1 |
| Monk, BJ | 1 |
| Barnett, AA | 1 |
| Haller, JC | 1 |
| Cairnduff, F | 1 |
| Lane, G | 1 |
| Brown, SB | 1 |
| Roberts, DJ | 1 |
| Andikyan, V | 2 |
| Kronschnabl, M | 1 |
| Andrejevic-Blant, S | 1 |
| Major, A | 1 |
| Lüdicke, F | 1 |
| Ballini, JP | 1 |
| Wagnières, G | 1 |
| van den Bergh, H | 1 |
| Pelte, MF | 1 |
| Martin-Hirsch, PL | 1 |
| Whitehurst, C | 1 |
| Buckley, CH | 1 |
| Moore, JV | 1 |
| Kitchener, HC | 1 |
| Pahernik, SA | 1 |
| Botzlar, A | 1 |
| Dellian, M | 1 |
| Kirschstein, M | 1 |
| Abels, C | 1 |
| Korell, M | 2 |
| Mueller-Hoecker, J | 1 |
| Untch, M | 2 |
| Goetz, AE | 1 |
| Schmitt-Sody, M | 1 |
| Baumgartner, R | 2 |
| Beyer, W | 1 |
| Kimmig, R | 1 |
| Hepp, H | 1 |
| Wierrani, F | 1 |
| Kubin, A | 1 |
| Jindra, R | 1 |
| Henry, M | 1 |
| Gharehbaghi, K | 1 |
| Grin, W | 1 |
| Söltz-Szötz, J | 1 |
| Alth, G | 1 |
| Grünberger, W | 1 |
| Weingandt, H | 1 |
| Diebold, J | 1 |
| Xiang, W | 1 |
| Chahine, EB | 1 |
| DiSaia, PJ | 1 |
| Krasieva, TB | 1 |
| Lin, F | 1 |
| Berns, MW | 1 |
| Duska, LR | 1 |
| Wimberly, J | 1 |
| Deutsch, TF | 1 |
| Ortel, B | 1 |
| Haas, J | 1 |
| Houck, K | 1 |
| Hasan, T | 1 |
| Bogaards, A | 1 |
| Aalders, MC | 1 |
| Zeyl, CC | 1 |
| de Blok, S | 1 |
| Sterenborg, HJ | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| The Effect of 5-aminolaevulinic Acid Photodynamic Therapy Versus C02 Laser in the Treatment of Persistent Cervical Low-grade Squamous Intraepithelial Lesions With High-risk HPV Infection:A Non-randomized Controlled Trail Study[NCT06052033] | 40 participants (Anticipated) | Interventional | 2023-09-11 | Recruiting | |||
| A Randomized Phase II Dose-finding Study of Hexaminolevulinate (HAL) Photodynamic Therapy (PDT) in Patients With Low/Moderate-grade Cervical Intraepithelial Neoplasia (CIN1 or 2)[NCT01256424] | Phase 2 | 262 participants (Actual) | Interventional | 2011-04-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
HPV response was defined as clearance of baseline HPV infection, asssessed by genotype (NCT01256424)
Timeframe: 3 months after treatment
| Intervention | percentage of patients (Number) |
|---|---|
| HAL 5% With Illumination | 62 |
| HAL 1% With Illumination | 38 |
| HAL 0.2% With Illumination | 41 |
| Placebo Ointment Without Illumination | 28 |
Lesion response was defined by three variables: Histology, cytology and HPV. Patient response at three months required histology regression to CIN1 or normal, cytology of LSIL or less severe, and HPV negative. (NCT01256424)
Timeframe: 3 months after last treatment
| Intervention | percentage of patients (Number) |
|---|---|
| HAL 5% With Illumination | 95 |
| HAL 1% With Illumination | 69 |
| HAL 0.2% With Illumination | 63 |
| Placebo Ointment Without Illumination | 57 |
Response was defined as absence of HSIL, and absence of oncogenic HPV if LSIL. (NCT01256424)
Timeframe: 6 months after first treatment
| Intervention | percentage of participants (Number) |
|---|---|
| HAL 5% With Illumination | 76 |
| HAL 1% With Illumination | 45 |
| HAL 0.2% With Illumination | 43 |
| Placebo Ointment Without Illumination | 28 |
Response was defined as absence of HSIL, and absence of oncogenic HPF if LSIL (NCT01256424)
Timeframe: 9 months after first treatment
| Intervention | percentage of participants (Number) |
|---|---|
| HAL 5% With Illumination | 76 |
| HAL 1% With Illumination | 50 |
| HAL 0.2% With Illumination | 43 |
| Placebo Ointment Without Illumination | 33 |
2 reviews available for aminolevulinic acid and Cervix Dysplasia
| Article | Year |
|---|---|
5-Aminolevulinic acid-based fluorescence diagnostics of cervical preinvasive changes.
Topics: Aminolevulinic Acid; Female; Fluorescence; Humans; Photosensitizing Agents; Protoporphyrins; Sensiti | 2014 |
Topical hexaminolevulinate photodynamic therapy for the treatment of persistent human papilloma virus infections and cervical intraepithelial neoplasia.
Topics: Aminolevulinic Acid; Female; Humans; Papillomavirus Infections; Photochemotherapy; Photosensitizing | 2015 |
14 trials available for aminolevulinic acid and Cervix Dysplasia
| Article | Year |
|---|---|
The effect of aminolevulinic acid hydrochloride topical powder photodynamic therapy versus nocardia rubra cell wall skeleton and observers group in the treatment of cervical low-grade squamous intraepithelial lesions with human papillomavirus infection: A
Topics: Aminolevulinic Acid; Cell Wall Skeleton; Female; Human Papillomavirus Viruses; Humans; Papillomaviru | 2023 |
Efficacy and safety of hexaminolevulinate photodynamic therapy in patients with low-grade cervical intraepithelial neoplasia.
Topics: Adult; Aminolevulinic Acid; Biopsy; Double-Blind Method; Female; Humans; Middle Aged; Photochemother | 2014 |
A randomized study of hexaminolevulinate photodynamic therapy in patients with cervical intraepithelial neoplasia 1/2.
Topics: Administration, Topical; Adolescent; Adult; Aminolevulinic Acid; Dose-Response Relationship, Drug; D | 2015 |
Photodynamic therapy of cervical intraepithelial neoplasia with hexaminolevulinate.
Topics: Adult; Aminolevulinic Acid; Feasibility Studies; Female; Humans; Papillomavirus Infections; Photoche | 2008 |
Clinical and immunohistochemical assessment of vulval intraepithelial neoplasia following photodynamic therapy using a novel bioadhesive patch-type system loaded with 5-aminolevulinic acid.
Topics: Administration, Topical; Adult; Aged; Aminolevulinic Acid; Drug Carriers; Female; Humans; Middle Age | 2009 |
Effects of photodynamic therapy using topical applied hexylaminolevulinate and methylaminolevulinate upon the integrity of cervical epithelium.
Topics: Administration, Topical; Adult; Aminolevulinic Acid; Biomarkers, Tumor; Cohort Studies; Double-Blind | 2010 |
Photodynamic therapy of cervical intraepithelial neoplasia 1-3 and human papilloma virus (HMV) infection with methylaminolevulinate and hexaminolevulinate--a double-blind, dose-finding study.
Topics: Adult; Aminolevulinic Acid; Double-Blind Method; Female; Humans; Papillomavirus Infections; Photoche | 2012 |
Photodynamic therapy of high-grade cervical intraepithelial neoplasia with 5-aminolevulinic acid.
Topics: Adult; Aminolevulinic Acid; Female; Follow-Up Studies; Humans; Outcome Assessment, Health Care; Phot | 2002 |
A randomised, double-blind, placebo-controlled trial of photodynamic therapy using 5-aminolaevulinic acid for the treatment of cervical intraepithelial neoplasia.
Topics: Administration, Topical; Adult; Aminolevulinic Acid; Cervix Uteri; Colposcopy; Double-Blind Method; | 2003 |
Photodynamic therapy in women with cervical intraepithelial neoplasia using topically applied 5-aminolevulinic acid.
Topics: Administration, Topical; Aminolevulinic Acid; Colposcopy; Female; Humans; Image Processing, Computer | 1999 |
5-aminolevulinic acid-mediated photodynamic therapy of intraepithelial neoplasia and human papillomavirus of the uterine cervix--a new experimental approach.
Topics: Administration, Intravaginal; Adolescent; Adult; Aminolevulinic Acid; Combined Modality Therapy; Dru | 1999 |
Photodetection of cervical intraepithelial neoplasia using 5-aminolevulinic acid-induced porphyrin fluorescence.
Topics: Adult; Aminolevulinic Acid; Female; Humans; Photosensitizing Agents; Porphyrins; Sensitivity and Spe | 2000 |
Fluorescence detection of cervical intraepithelial neoplasia for photodynamic therapy with the topical agents 5-aminolevulinic acid and benzoporphyrin-derivative monoacid ring.
Topics: Absorption; Aminolevulinic Acid; Cervix Uteri; Female; Humans; Microscopy, Fluorescence; Photochemot | 2001 |
Detection of female lower genital tract dysplasia using orally administered 5-aminolevulinic acid induced protoporphyrin IX: a preliminary study.
Topics: Administration, Oral; Aminolevulinic Acid; Female; Humans; Papanicolaou Test; Photochemotherapy; Pro | 2002 |
27 other studies available for aminolevulinic acid and Cervix Dysplasia
| Article | Year |
|---|---|
Effect and rational application of topical photodynamic therapy (PDT) with 5-aminolevulinic acid (5-ALA) for treatment of cervical intraepithelial neoplasia with vaginal intraepithelial neoplasia.
Topics: Aminolevulinic Acid; Female; Human papillomavirus 16; Human papillomavirus 18; Humans; Papillomaviru | 2022 |
Clinical outcome of photodynamic therapy for the treatment of cervical intraepithelial neoplasia grade 2.
Topics: Aminolevulinic Acid; Female; Humans; Papillomavirus Infections; Photochemotherapy; Photosensitizing | 2022 |
The effect of high-risk HPV E6/E7 mRNA on the efficacy of topical photodynamic therapy with 5-aminolevulinic acid for cervical high-grade squamous intraepithelial lesions.
Topics: Aminolevulinic Acid; Female; Human papillomavirus 16; Human papillomavirus 18; Humans; Neoplasm Recu | 2022 |
Management of patients with positive margin after conization for high-grade cervical intraepithelial lesions.
Topics: Aminolevulinic Acid; Conization; Female; Humans; Margins of Excision; Neoplasm Recurrence, Local; Pa | 2022 |
Evaluation of 5-aminolevulinic acid-mediated photodynamic therapy in postmenopausal women with persistent HPV infection with or without cervical and vaginal low-grade squamous intraepithelial lesions (CIN1/VaIN1).
Topics: Aminolevulinic Acid; Female; Humans; Papillomaviridae; Papillomavirus Infections; Photochemotherapy; | 2022 |
Topical 5-aminolevulinic acid photodynamic therapy for cervical high-grade squamous intraepithelial lesions.
Topics: Aminolevulinic Acid; Female; Humans; Papillomaviridae; Papillomavirus Infections; Photochemotherapy; | 2022 |
The effect of local photodynamic therapy with 5-aminolevulinic acid in treating different grades of cervical intraepithelial neoplasia.
Topics: Aminolevulinic Acid; Female; Humans; Neoplasm Recurrence, Local; Papillomavirus Infections; Photoche | 2022 |
A pilot study of repeated 5-aminolevulinic acid photodynamic therapy for cervical intraepithelial neoplasia by a newly developed intravaginal irradiation system.
Topics: Aminolevulinic Acid; Female; Humans; Papillomavirus Infections; Photochemotherapy; Photosensitizing | 2023 |
The effects of 5-aminolevulinic acid photodynamic therapy on the local immune response of women with cervical intraepithelial neoplasia grade 2.
Topics: Aminolevulinic Acid; CD8-Positive T-Lymphocytes; Female; Humans; Papillomavirus Infections; Photoche | 2023 |
Loop electrosurgical excision procedure followed by 5-aminolevulinic acid photodynamic therapy for cervical intraepithelial neoplasia, a report of six cases.
Topics: Adult; Aminolevulinic Acid; Combined Modality Therapy; Electrosurgery; Female; Humans; Middle Aged; | 2020 |
High-risk HPV clearance and CIN 3 treated with MAL-PDT: A case report.
Topics: Adult; Aminolevulinic Acid; Female; Humans; Neoplasm Recurrence, Local; Papillomavirus Infections; P | 2020 |
Treatment of HPV Infection-Associated Low Grade Cervical Intraepithelial Neoplasia with 5-Aminolevulinic Acid-Mediated Photodynamic Therapy.
Topics: Adult; Aminolevulinic Acid; Female; Humans; Papillomavirus Infections; Photochemotherapy; Photosensi | 2020 |
Efficacy of 5-aminolevulinic acid and LED photodynamic therapy in cervical intraepithelial neoplasia: A clinical trial.
Topics: Aminolevulinic Acid; Female; Humans; Neoplasm Recurrence, Local; Photochemotherapy; Photosensitizing | 2020 |
Photodetection and Safety of 5-Aminolevulinic Acid-Induced Porphyrin in Patients With Cervical Intraepithelial Neoplasia.
Topics: Aminolevulinic Acid; Female; Humans; Porphyrins; Retrospective Studies; Uterine Cervical Dysplasia; | 2021 |
The effect of local photodynamic therapy with 5-aminolevulinic acid for the treatment of cervical low-grade squamous intraepithelial lesions with high-risk HPV infection: A retrospective study.
Topics: Adult; Aged; Aminolevulinic Acid; Female; Human papillomavirus 16; Human papillomavirus 18; Humans; | 2021 |
Efficacy and safety of photodynamic therapy mediated by 5-aminolevulinic acid for the treatment of cervical intraepithelial neoplasia 2: A single-center, prospective, cohort study.
Topics: Aminolevulinic Acid; Cohort Studies; Female; Humans; Photochemotherapy; Photosensitizing Agents; Pro | 2021 |
Effectiveness of Photodynamic Therapy in Elimination of HPV-16 and HPV-18 Associated with CIN I in Mexican Women.
Topics: Adult; Aminolevulinic Acid; Female; Human papillomavirus 16; Human papillomavirus 18; Humans; Mexico | 2017 |
5-aminolevulinic-acid-based fluorescence spectroscopy and conventional colposcopy for in vivo detection of cervical pre-malignancy.
Topics: Adult; Aminolevulinic Acid; Colposcopy; Early Detection of Cancer; Female; Humans; Middle Aged; Phot | 2015 |
Sensitization of immune cells following hexylaminolevulinate photodynamic therapy of cervical intraepithelial neoplasia.
Topics: Aminolevulinic Acid; CD4-CD8 Ratio; Cell Cycle; Female; Human papillomavirus 16; Humans; Leukocytes, | 2017 |
Successful photodynamic therapy with topical 5-aminolevulinic acid for five cases of cervical intraepithelial neoplasia.
Topics: Administration, Topical; Adult; Aminolevulinic Acid; Female; Humans; Middle Aged; Papillomavirus Inf | 2010 |
Treatment of high grade cervical intraepithelial neoplasia by photodynamic therapy using hexylaminolevulinate may be costeffective compared to conisation procedures due to decreased pregnancy-related morbidity.
Topics: Aminolevulinic Acid; Cervix Uteri; Conization; Cost-Benefit Analysis; Female; Germany; Health Care C | 2011 |
[Fluorescence diagnosis with 5-ALA thermogel of cervical intraepithelial neoplasia].
Topics: Adult; Aminolevulinic Acid; Biopsy; Cervix Uteri; Conization; Data Interpretation, Statistical; Fema | 2004 |
Time-dependent hexaminolaevulinate induced protoporphyrin IX distribution after topical application in patients with cervical intraepithelial neoplasia: A fluorescence microscopy study.
Topics: Administration, Topical; Adult; Aminolevulinic Acid; Female; Humans; Microscopy, Fluorescence; Middl | 2004 |
Pharmacokinetics and selectivity of porphyrin synthesis after topical application of hexaminolevulinate in patients with cervical intraepithelial neoplasia.
Topics: Administration, Topical; Adult; Aminolevulinic Acid; Carbon Radioisotopes; Female; Fluorescence; Hum | 2008 |
Photodynamic treatment for lower genital tract intraepithelial neoplasia.
Topics: Aminolevulinic Acid; Carcinoma in Situ; Female; Humans; Photochemotherapy; Photosensitizing Agents; | 1998 |
Pharmacokinetics and selectivity of aminolevulinic acid-induced porphyrin synthesis in patients with cervical intra-epithelial neoplasia.
Topics: Adult; Aminolevulinic Acid; Cervix Uteri; Conization; Epithelial Cells; Female; Humans; Microscopy, | 1998 |
Localization and staging of cervical intraepithelial neoplasia using double ratio fluorescence imaging.
Topics: Adult; Aminolevulinic Acid; Colposcopy; Female; Humans; Middle Aged; Monte Carlo Method; Neoplasm St | 2002 |