aminolevulinic acid has been researched along with Cell Transformation, Neoplastic in 11 studies
Aminolevulinic Acid: A compound produced from succinyl-CoA and GLYCINE as an intermediate in heme synthesis. It is used as a PHOTOCHEMOTHERAPY for actinic KERATOSIS.
5-aminolevulinic acid : The simplest delta-amino acid in which the hydrogens at the gamma position are replaced by an oxo group. It is metabolised to protoporphyrin IX, a photoactive compound which accumulates in the skin. Used (in the form of the hydrochloride salt)in combination with blue light illumination for the treatment of minimally to moderately thick actinic keratosis of the face or scalp.
Cell Transformation, Neoplastic: Cell changes manifested by escape from control mechanisms, increased growth potential, alterations in the cell surface, karyotypic abnormalities, morphological and biochemical deviations from the norm, and other attributes conferring the ability to invade, metastasize, and kill.
| Excerpt | Relevance | Reference |
|---|---|---|
| " In this study, we used 5-aminolevulinic (ALA) acid and 3 water soluble photosensitizers-PP(Arg)(2), PP(Ser)(2)Arg(2), PP(Ala)(2)Arg(2), all diamino acid derivatives of protoporphyrin IX-to treat benign papillomas in FVB/N mice induced by 7,12-dimethylbenz(a)anthracene (DMBA)-12-O-tetradecanoyl-phorbol-13-acetate (TPA)." | 7.75 | Photodynamic therapy with 5-aminolevulinic acid and diamino acid derivatives of protoporphyrin IX reduces papillomas in mice without eliminating transformation into squamous cell carcinoma of the skin. ( Dziadziuszko, H; Glosnicka, R; Graczyk, A; Jankowski, D; Jaskiewicz, K; Juzeniene, A; Kaliszewski, M; Kunikowska, D; Kwasny, M; Kwitniewski, M; Ma, LW; Moan, J; Peksa, R, 2009) |
| " In this study, we used 5-aminolevulinic (ALA) acid and 3 water soluble photosensitizers-PP(Arg)(2), PP(Ser)(2)Arg(2), PP(Ala)(2)Arg(2), all diamino acid derivatives of protoporphyrin IX-to treat benign papillomas in FVB/N mice induced by 7,12-dimethylbenz(a)anthracene (DMBA)-12-O-tetradecanoyl-phorbol-13-acetate (TPA)." | 3.75 | Photodynamic therapy with 5-aminolevulinic acid and diamino acid derivatives of protoporphyrin IX reduces papillomas in mice without eliminating transformation into squamous cell carcinoma of the skin. ( Dziadziuszko, H; Glosnicka, R; Graczyk, A; Jankowski, D; Jaskiewicz, K; Juzeniene, A; Kaliszewski, M; Kunikowska, D; Kwasny, M; Kwitniewski, M; Ma, LW; Moan, J; Peksa, R, 2009) |
| "Head and neck cancer (HNC) ranks the fourth leading malignancy and cancer death in male population in Taiwan." | 1.40 | Photodynamic therapy with 5-aminolevulinic acid (ALA) impairs tumor initiating and chemo-resistance property in head and neck cancer-derived cancer stem cells. ( Yu, CC; Yu, CH, 2014) |
| "Eight patients with Barrett's esophagus and/or early cancer were treated." | 1.31 | [Photodynamic therapy of dysplasias and early carcinomas in Barrett esophagus with a diode laser system--a pilot study]. ( Apel, D; Arnold, JC; Jakobs, R; Riemann, JF; Rosenbaum, A; Zöpf, T, 2001) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (9.09) | 18.2507 |
| 2000's | 5 (45.45) | 29.6817 |
| 2010's | 3 (27.27) | 24.3611 |
| 2020's | 2 (18.18) | 2.80 |
| Authors | Studies |
|---|---|
| Zhang, Q | 1 |
| Wang, F | 1 |
| Liang, J | 1 |
| Kuang, W | 1 |
| Zeng, X | 1 |
| Zhang, X | 1 |
| Teh, DBL | 1 |
| Bansal, A | 1 |
| Chai, C | 1 |
| Toh, TB | 1 |
| Tucker, RAJ | 1 |
| Gammad, GGL | 1 |
| Yeo, Y | 1 |
| Lei, Z | 1 |
| Zheng, X | 1 |
| Yang, F | 1 |
| Ho, JS | 1 |
| Bolem, N | 1 |
| Wu, BC | 1 |
| Gnanasammandhan, MK | 1 |
| Hooi, L | 1 |
| Dawe, GS | 1 |
| Libedinsky, C | 1 |
| Ong, WY | 1 |
| Halliwell, B | 1 |
| Chow, EK | 1 |
| Lim, KL | 1 |
| Zhang, Y | 1 |
| Kennedy, BK | 1 |
| Yu, CH | 1 |
| Yu, CC | 1 |
| Kwitniewski, M | 1 |
| Jankowski, D | 1 |
| Jaskiewicz, K | 1 |
| Dziadziuszko, H | 1 |
| Juzeniene, A | 1 |
| Moan, J | 1 |
| Ma, LW | 1 |
| Peksa, R | 1 |
| Kunikowska, D | 1 |
| Graczyk, A | 1 |
| Kwasny, M | 1 |
| Kaliszewski, M | 1 |
| Glosnicka, R | 1 |
| Piccirillo, SG | 1 |
| Dietz, S | 1 |
| Madhu, B | 1 |
| Griffiths, J | 1 |
| Price, SJ | 1 |
| Collins, VP | 1 |
| Watts, C | 1 |
| Endlicher, E | 1 |
| Gelbmann, CM | 1 |
| Knüchel, R | 1 |
| Fürst, A | 1 |
| Szeimies, RM | 1 |
| Gölder, SK | 1 |
| Schölmerich, J | 1 |
| Lottner, C | 1 |
| Messmann, H | 1 |
| Franco, RA | 1 |
| Li, G | 1 |
| Szewczuk, MR | 1 |
| Raptis, L | 1 |
| Johnson, JG | 1 |
| Weagle, GE | 1 |
| Pottier, RH | 1 |
| Kennedy, JC | 1 |
| Zöpf, T | 1 |
| Rosenbaum, A | 1 |
| Apel, D | 1 |
| Jakobs, R | 1 |
| Arnold, JC | 1 |
| Riemann, JF | 1 |
| Eisendrath, P | 1 |
| Van Laethem, JL | 1 |
| Yang, X | 1 |
| Palasuberniam, P | 1 |
| Myers, KA | 1 |
| Wang, C | 1 |
| Chen, B | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| The Correlation of Surgical Colorectal Cancer Specimen Pathology With the Fluorescence of Photodynamic Diagnostics (PDD): a Clinical Pilot Study[NCT03272659] | Phase 2 | 0 participants (Actual) | Interventional | 2018-04-01 | Withdrawn (stopped due to Long process and due to strict deadline, project was stopped.) | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
11 other studies available for aminolevulinic acid and Cell Transformation, Neoplastic
| Article | Year |
|---|---|
Photodynamic therapy for extensive oral verrucous/granular leukoplakia with moderate-to-severe dysplasia: A case study.
Topics: Aminolevulinic Acid; Cell Transformation, Neoplastic; Humans; Leukoplakia, Oral; Male; Middle Aged; | 2022 |
A Flexi-PEGDA Upconversion Implant for Wireless Brain Photodynamic Therapy.
Topics: Aminolevulinic Acid; Animals; Brain Neoplasms; Cell Line, Tumor; Cell Transformation, Neoplastic; Gl | 2020 |
Photodynamic therapy with 5-aminolevulinic acid (ALA) impairs tumor initiating and chemo-resistance property in head and neck cancer-derived cancer stem cells.
Topics: Aldehyde Dehydrogenase 1 Family; Aminolevulinic Acid; Biomarkers, Tumor; Cell Line, Tumor; Cell Tran | 2014 |
Photodynamic therapy with 5-aminolevulinic acid and diamino acid derivatives of protoporphyrin IX reduces papillomas in mice without eliminating transformation into squamous cell carcinoma of the skin.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Aminolevulinic Acid; Animals; Carcinogens; Carcinoma, Squamous Cel | 2009 |
Fluorescence-guided surgical sampling of glioblastoma identifies phenotypically distinct tumour-initiating cell populations in the tumour mass and margin.
Topics: Adult; Aged; Aminolevulinic Acid; Animals; Brain Neoplasms; Cell Transformation, Neoplastic; Female; | 2012 |
Hexaminolevulinate-induced fluorescence endoscopy in patients with rectal adenoma and cancer: a pilot study.
Topics: Adenoma; Aged; Aged, 80 and over; Aminolevulinic Acid; Biopsy; Carcinoma in Situ; Cell Transformatio | 2004 |
Aminolevulinic acid 585 nm pulsed dye laser photodynamic treatment of laryngeal keratosis with atypia.
Topics: Administration, Topical; Aged; Ambulatory Care; Aminolevulinic Acid; Biopsy; Cell Transformation, Ne | 2007 |
Rodent fibroblast model for studies of response of malignant cells to exogenous 5-aminolevulinic acid.
Topics: 3T3 Cells; Aminolevulinic Acid; Animals; Cell Line, Transformed; Cell Transformation, Neoplastic; Ce | 1999 |
[Photodynamic therapy of dysplasias and early carcinomas in Barrett esophagus with a diode laser system--a pilot study].
Topics: Adenocarcinoma; Aged; Aminolevulinic Acid; Barrett Esophagus; Cell Transformation, Neoplastic; Esoph | 2001 |
Endoscopic fluorescence detection of low and high grade dysplasia in Barrett's oesophagus using systemic or local 5-aminolaevulinic acid sensitization.
Topics: Administration, Oral; Administration, Topical; Aminolevulinic Acid; Barrett Esophagus; Cell Transfor | 2002 |
Her2 oncogene transformation enhances 5-aminolevulinic acid-mediated protoporphyrin IX production and photodynamic therapy response.
Topics: Aminolevulinic Acid; Breast Neoplasms; Cell Line, Tumor; Cell Survival; Cell Transformation, Neoplas | 2016 |