aminolevulinic acid has been researched along with Carcinoma, Epidermoid in 221 studies
Aminolevulinic Acid: A compound produced from succinyl-CoA and GLYCINE as an intermediate in heme synthesis. It is used as a PHOTOCHEMOTHERAPY for actinic KERATOSIS.
5-aminolevulinic acid : The simplest delta-amino acid in which the hydrogens at the gamma position are replaced by an oxo group. It is metabolised to protoporphyrin IX, a photoactive compound which accumulates in the skin. Used (in the form of the hydrochloride salt)in combination with blue light illumination for the treatment of minimally to moderately thick actinic keratosis of the face or scalp.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Although having shown promising clinical outcomes, the effectiveness of 5-aminolevulinic acid-based photodynamic therapy (ALA-PDT) for squamous cell carcinoma (SCC) and glioblastoma remains to be improved." | 7.91 | Methadone enhances the effectiveness of 5-aminolevulinic acid-based photodynamic therapy for squamous cell carcinoma and glioblastoma in vitro. ( Buchner, A; Gederaas, OA; Pohla, H; Pongratz, T; Rühm, A; Shi, L; Sroka, R; Stepp, H; Wang, X; Zhang, L; Zimmermann, W, 2019) |
| "The present research work describes the use of photodynamic therapy (PDT) of drug 5-aminolevulinic acid (5-ALA) conjugated with microbial synthesised silver nanoparticles on skin melanoma (B16F10) and epidermoid carcinoma (A431) cell lines." | 7.91 | Photodynamic therapy on skin melanoma and epidermoid carcinoma cells using conjugated 5-aminolevulinic acid with microbial synthesised silver nanoparticles. ( Sanjay, KR; Shivashankarappa, A, 2019) |
| " In this study, we used 5-aminolevulinic (ALA) acid and 3 water soluble photosensitizers-PP(Arg)(2), PP(Ser)(2)Arg(2), PP(Ala)(2)Arg(2), all diamino acid derivatives of protoporphyrin IX-to treat benign papillomas in FVB/N mice induced by 7,12-dimethylbenz(a)anthracene (DMBA)-12-O-tetradecanoyl-phorbol-13-acetate (TPA)." | 7.75 | Photodynamic therapy with 5-aminolevulinic acid and diamino acid derivatives of protoporphyrin IX reduces papillomas in mice without eliminating transformation into squamous cell carcinoma of the skin. ( Dziadziuszko, H; Glosnicka, R; Graczyk, A; Jankowski, D; Jaskiewicz, K; Juzeniene, A; Kaliszewski, M; Kunikowska, D; Kwasny, M; Kwitniewski, M; Ma, LW; Moan, J; Peksa, R, 2009) |
| "We report the case of a 82-year-old man who, after multiple treatments with aminolevulinic acid photodynamic therapy for solar keratoses and superficial squamous cell carcinomas, developed malignant melanoma at the exposed site on the scalp." | 7.69 | Development of malignant melanoma after repeated topical photodynamic therapy with 5-aminolevulinic acid at the exposed site. ( Fink-Puches, R; Kerl, H; Reimann-Weber, A; Wolf, P, 1997) |
| "COL 0·5% cream and MAL-PDT are safe and effective for treating SFC." | 6.87 | Effectiveness and safety of 0·5% colchicine cream vs. photodynamic therapy with methyl aminolaevulinate in the treatment of actinic keratosis and skin field cancerization of the forearms: a randomized controlled trial. ( Abbade, LPF; Ferreira, ER; Lima, TRR; Miola, AC; Miot, HA; Schmitt, JV, 2018) |
| " Mild or moderate adverse effects were similar for both groups." | 6.87 | Effectiveness and safety of 0·5% colchicine cream vs. photodynamic therapy with methyl aminolaevulinate in the treatment of actinic keratosis and skin field cancerization of the forearms: a randomized controlled trial. ( Abbade, LPF; Ferreira, ER; Lima, TRR; Miola, AC; Miot, HA; Schmitt, JV, 2018) |
| "A total of six cases of ulcerative squamous cell carcinoma were included in our study." | 5.56 | Efficacy and safety of 5-aminolevulinic acid photodynamic therapy for the treatment of ulcerative squamous cell carcinoma. ( Dong, L; Li, X; Lu, Y; Shen, X; Wang, Y; Zhang, J; Zhang, W, 2020) |
| "Silver nanoparticles were synthesised using the bacterial strain Bacillus licheniformis." | 5.51 | Photodynamic therapy on skin melanoma and epidermoid carcinoma cells using conjugated 5-aminolevulinic acid with microbial synthesised silver nanoparticles. ( Sanjay, KR; Shivashankarappa, A, 2019) |
| "Laser therapy appears the best option among nonsurgical approaches for actinic cheilitis, and PDT showed higher efficacy when sequentially combined with 5% imiquimod." | 5.05 | Treatments of actinic cheilitis: A systematic review of the literature. ( Cornacchia, L; Lai, M; Longo, C; Pampena, R; Pellacani, G; Peris, K, 2020) |
| "Studies comparing 5-fluorouracil (5-FU), imiquimod, and photodynamic therapy with aminolevulinic acid (PDT-ALA) have evaluated the efficacy of destroying actinic keratosis (AK)." | 4.12 | A comparison of invasive squamous cell carcinoma greater than 1 year after treatment with 5-fluorouracil, imiquimod, or photodynamic therapy with aminolevulinic acid. ( Cheng, B; Etzkorn, JR; Giordano, CN; Higgins, HW; Miller, CJ; Shin, TM; Sobanko, JF; Veerabagu, S, 2022) |
| "5-Aminolevulinic acid photodynamic therapy (ALA-PDT) is an effective modality for vulvar lichen sclerosus (VLS) and squamous cell carcinoma (SCC) in situ." | 4.12 | Vulvar lichen sclerosus progressing to squamous cell carcinoma due to the poor compliance for the follow-up after ALA-PDT. ( Liu, J; Shi, L; Wang, P; Wang, X; Zhang, G; Zhang, H; Zhang, Y; Zhou, Z, 2022) |
| "Photodynamic therapy (PDT) has been reported as a treatment for cutaneous squamous cell carcinoma in situ (SCCis), but only limited data are available on the effectiveness of PDT with aminolevulinic acid (ALA-PDT)." | 3.96 | Photodynamic therapy for cutaneous squamous cell carcinoma in situ: Impact of anatomic location, tumor diameter, and incubation time on effectiveness. ( Christensen, SR; Kibbi, N; Leffell, DJ; Zhang, Y, 2020) |
| "Although having shown promising clinical outcomes, the effectiveness of 5-aminolevulinic acid-based photodynamic therapy (ALA-PDT) for squamous cell carcinoma (SCC) and glioblastoma remains to be improved." | 3.91 | Methadone enhances the effectiveness of 5-aminolevulinic acid-based photodynamic therapy for squamous cell carcinoma and glioblastoma in vitro. ( Buchner, A; Gederaas, OA; Pohla, H; Pongratz, T; Rühm, A; Shi, L; Sroka, R; Stepp, H; Wang, X; Zhang, L; Zimmermann, W, 2019) |
| "The present research work describes the use of photodynamic therapy (PDT) of drug 5-aminolevulinic acid (5-ALA) conjugated with microbial synthesised silver nanoparticles on skin melanoma (B16F10) and epidermoid carcinoma (A431) cell lines." | 3.91 | Photodynamic therapy on skin melanoma and epidermoid carcinoma cells using conjugated 5-aminolevulinic acid with microbial synthesised silver nanoparticles. ( Sanjay, KR; Shivashankarappa, A, 2019) |
| " In this study, we used 5-aminolevulinic (ALA) acid and 3 water soluble photosensitizers-PP(Arg)(2), PP(Ser)(2)Arg(2), PP(Ala)(2)Arg(2), all diamino acid derivatives of protoporphyrin IX-to treat benign papillomas in FVB/N mice induced by 7,12-dimethylbenz(a)anthracene (DMBA)-12-O-tetradecanoyl-phorbol-13-acetate (TPA)." | 3.75 | Photodynamic therapy with 5-aminolevulinic acid and diamino acid derivatives of protoporphyrin IX reduces papillomas in mice without eliminating transformation into squamous cell carcinoma of the skin. ( Dziadziuszko, H; Glosnicka, R; Graczyk, A; Jankowski, D; Jaskiewicz, K; Juzeniene, A; Kaliszewski, M; Kunikowska, D; Kwasny, M; Kwitniewski, M; Ma, LW; Moan, J; Peksa, R, 2009) |
| "To determine the effect of photodynamic therapy mediated by 5-aminolevulinic acid (ALA) on a range of bladder cancer cell lines, including a squamous cancer cell line and a multi-drug resistant cell line." | 3.69 | Photodynamic therapy of bladder cancer cell lines. ( Allman, R; Datta, SN; Loh, CS; Mason, M; Matthews, PN, 1997) |
| "We report the case of a 82-year-old man who, after multiple treatments with aminolevulinic acid photodynamic therapy for solar keratoses and superficial squamous cell carcinomas, developed malignant melanoma at the exposed site on the scalp." | 3.69 | Development of malignant melanoma after repeated topical photodynamic therapy with 5-aminolevulinic acid at the exposed site. ( Fink-Puches, R; Kerl, H; Reimann-Weber, A; Wolf, P, 1997) |
| "COL 0·5% cream and MAL-PDT are safe and effective for treating SFC." | 2.87 | Effectiveness and safety of 0·5% colchicine cream vs. photodynamic therapy with methyl aminolaevulinate in the treatment of actinic keratosis and skin field cancerization of the forearms: a randomized controlled trial. ( Abbade, LPF; Ferreira, ER; Lima, TRR; Miola, AC; Miot, HA; Schmitt, JV, 2018) |
| " Mild or moderate adverse effects were similar for both groups." | 2.87 | Effectiveness and safety of 0·5% colchicine cream vs. photodynamic therapy with methyl aminolaevulinate in the treatment of actinic keratosis and skin field cancerization of the forearms: a randomized controlled trial. ( Abbade, LPF; Ferreira, ER; Lima, TRR; Miola, AC; Miot, HA; Schmitt, JV, 2018) |
| "BACKGROUND Squamous cell carcinoma (SCC) is the second most common type of skin cancer, for which non- or mini-invasive treatment is of critical importance." | 2.84 | A Clinical Trial Using Attrition Combined with 5-Aminolevulinic Acids Based Photodynamic Therapy in Treating Squamous Cell Carcinoma. ( Dai, Y; Feng, W; Luo, X; Peng, J; Wang, T; Xiang, W; Zheng, J; Zhu, J, 2017) |
| "Fluorouracil was applied for 4 weeks." | 2.72 | Comparison of topical methyl aminolevulinate photodynamic therapy with cryotherapy or Fluorouracil for treatment of squamous cell carcinoma in situ: Results of a multicenter randomized trial. ( Bedane, C; Horn, M; Ibbotson, S; Khemis, A; Leman, J; Morton, C; Tack, B; Tjioe, M; Wolf, P, 2006) |
| "5-Aminolevulinic acid (5-ALA) is a useful agent to enhance the detection of early epithelial lesions in head and neck cancers." | 2.71 | Excretion measurement of porphyrins and their precursors after topical administration of 5-aminolaevulinic acid for fluorescence endoscopy in head and neck cancer. ( Brossmann, P; Doss, MO; Gross, U; Klahr, N; Klein, M; Külkens, C; Lippert, BM; Ney, M; Teymoortash, A; Werner, JA, 2003) |
| "Improvement regarding dysphagia, stenosis diameter, and tumor length could be obtained in both treatment arms with a significant difference in favour of the Photosan-group, P = 0." | 2.70 | Does new photosensitizer improve photodynamic therapy in advanced esophageal carcinoma? ( Maier, A; Matzi, V; Pinter, H; Rehak, P; Smolle-Jüttner, FM; Tomaselli, F, 2001) |
| "Reduction of tumor stenosis, increase in quality of life, and phototoxicity were considered as primary objectives." | 2.70 | Comparison of 5-aminolaevulinic acid and porphyrin photosensitization for photodynamic therapy of malignant bronchial stenosis: a clinical pilot study. ( Anegg, U; Fell, B; Maier, A; Matzi, V; Pinter, H; Rehak, P; Smolle-Jüttner, FM; Tomaselli, F; Woltsche, M, 2002) |
| "There was a patient with Bowen's disease of the penis." | 2.69 | [Topical photodynamic therapy in basal and squamous cell carcinoma and penile Bowen's disease with 20% aminolevulinic acid, and exposure to red light and infrared light]. ( Harth, Y; Hirshovitz, B, 1998) |
| "Two patients had squamous cell carcinoma of the mid-esophagus and three had adenocarcinoma of the distal esophagus." | 2.69 | Photodynamic therapy of cancer of the esophagus using systemic aminolevulinic acid and a non laser light source: a phase I/II study. ( Haddad, R; Kashtan, H; Konikoff, F; Skornick, Y, 1999) |
| "For large areas of Bowen's disease, particularly in anatomically difficult areas and in elderly patients, PDT using ALA may constitute a single simple alternative outpatient treatment to existing therapies." | 2.67 | Superficial photodynamic therapy with topical 5-aminolaevulinic acid for superficial primary and secondary skin cancer. ( Ash, DV; Brown, SB; Cairnduff, F; Hudson, EJ; Stringer, MR, 1994) |
| "The reported numbers of PMDS and HNSCC ranged between 5 and 225." | 2.58 | Photodynamic treatment outcomes of potentially-malignant lesions and malignancies of the head and neck region: A systematic review. ( Choudhary, MG; Gadbail, AR; Gondivkar, SM; Likhitkar, MS; Vedpathak, PR, 2018) |
| "Erythroplasia of Queyrat (EOQ) is a squamous cell carcinoma in situ most commonly located on the glans penis or prepuce." | 2.53 | Erythroplasia of Queyrat treated by laser and light modalities: a systematic review. ( Jimenez, JJ; Lim, VM; Maranda, EL; Nguyen, AH; Shah, VV, 2016) |
| "With regard to squamous cell carcinoma, treatment with 5-fluorouracil, methotrexate, interferon, and bleomycin are reviewed." | 2.47 | Intralesional agents in the management of cutaneous malignancy: a review. ( Good, LM; High, WA; Miller, MD, 2011) |
| "Actinic keratosis is currently believed to be an early stage in the evolution of squamous cell carcinoma." | 2.42 | Topical and light-based treatments for actinic keratoses. ( Alam, M; Goldberg, LH; Silapunt, S, 2003) |
| "As the first stage of squamous cell carcinoma, actinic keratosis is worthy of prompt evaluation and active treatment." | 2.42 | Topical and light-based treatments for actinic keratoses. ( Alam, M; Goldberg, LH; Silapunt, S, 2003) |
| "The ALA-PDL-PDT protocol is a safe and well-tolerated treatment option for isSCC on the face, providing excellent cosmetic and functional results." | 1.91 | Evaluating the safety and efficacy of aminolevulinic acid 20% topical solution activated by pulsed dye laser and blue light in the treatment of facial cutaneous squamous cell carcinoma in situ. ( Ceci, FM; Gade, A; Han, H; Lawson, A; Nestor, MS, 2023) |
| "Oral squamous cell carcinoma (OSCC) can be characterized by severe functional impairment and a poor prognosis." | 1.72 | Nimotuzumab shows an additive effect to inhibit cell growth of ALA-PDT treated oral cancer cells. ( He, X; Hu, L; Hu, N; Wang, X; Wen, N; Yang, S; Yang, Z, 2022) |
| "Non-melanoma skin cancer (NMSC) is the most common malignancy worldwide, with rising incidence in the recent years." | 1.72 | In vitro 5-Fluorouracil resistance produces enhanced photodynamic therapy damage in SCC and tumor resistance in BCC. ( Gilaberte, Y; González, S; Gutiérrez-Pérez, M; Juarranz, Á; Nicolás-Morala, J; Portillo-Esnaola, M; Terrén, S, 2022) |
| "Grade 3 AK is considered early squamous cell carcinoma in situ (SCCis)." | 1.72 | A combination of laser-assisted ALA-PDT for squamous cell carcinoma in situ and field-directed ALA-PDT for actinic keratosis. ( Hu, C; Liu, X; Shen, S; Wang, P; Wang, X; Yang, X, 2022) |
| "Additionally, a oral cancer Xenograft model of nude mice was built to test its inhibitive effect on the cancerous growth in vivo." | 1.62 | Co-delivery of chitosan nanoparticles of 5-aminolevulinic acid and shGBAS for improving photodynamic therapy efficacy in oral squamous cell carcinomas. ( Li, S; Liu, H; Wang, X, 2021) |
| "Skin squamous cell carcinoma (SCC) is the second most common skin cancer, and surgical resection is the first choice of treatment." | 1.56 | Photodynamic therapy for squamous cell carcinoma of the index finger: A case report. ( Ma, J; Wang, X, 2020) |
| "A total of six cases of ulcerative squamous cell carcinoma were included in our study." | 1.56 | Efficacy and safety of 5-aminolevulinic acid photodynamic therapy for the treatment of ulcerative squamous cell carcinoma. ( Dong, L; Li, X; Lu, Y; Shen, X; Wang, Y; Zhang, J; Zhang, W, 2020) |
| "India has one of the highest rates of oral cancer incidence in the world, accounting for 30% of reported cancers." | 1.56 | Clinical evaluation of smartphone-based fluorescence imaging for guidance and monitoring of ALA-PDT treatment of early oral cancer. ( Akhtar, K; Bown, SG; Celli, JP; Cuckov, F; Daly, L; Hasan, SA; Hasan, T; Hopper, C; Hussain, MAB; Khan, AP; Khan, S; Leon, P; Liu, H; Mallidi, S; Rudd, G; Siddiqui, S; Siddiqui, SA, 2020) |
| " In cell culture, we show that the overall dose-response is consistent with established light sources and complete cell death of ALA photosensitized cells can be achieved in the irradiated zone." | 1.51 | Development and evaluation of a low-cost, portable, LED-based device for PDT treatment of early-stage oral cancer in resource-limited settings. ( Celli, JP; Cuckov, F; Daly, L; Hasan, T; Khan, AP; Liu, H; Liu, Y; Mallidi, S; Rudd, G, 2019) |
| "Silver nanoparticles were synthesised using the bacterial strain Bacillus licheniformis." | 1.51 | Photodynamic therapy on skin melanoma and epidermoid carcinoma cells using conjugated 5-aminolevulinic acid with microbial synthesised silver nanoparticles. ( Sanjay, KR; Shivashankarappa, A, 2019) |
| "It is reported that ALA-PDT treating cutaneous squamous cell carcinoma(cSCC) also induce antitumor immune effect and has an impact on tumor microenvironment." | 1.51 | The effect of ALA-PDT on reversing the activation of cancer-associated fibroblasts in cutaneous squamous cell carcinoma. ( Ji, J; Li, S; Lv, T; Wang, H; Wang, P; Wang, X; Zhang, G, 2019) |
| " The results of combination index indicated that HBO combination with PDT synergistically inhibited A431 cells proliferation in vitro." | 1.51 | Hyperbaric Oxygen Combined with 5-Aminolevulinic Acid Photodynamic Therapy Inhibited Human Squamous Cell Proliferation. ( Fang, F; Mei, LH; Yang, G, 2019) |
| "The treatment for giant cutaneous squamous cell carcinoma (cSCC) is challenging." | 1.46 | Novel strategy in giant cutaneous squamous cell carcinoma treatment: The case experience with a combination of photodynamic therapy and surgery. ( Bu, W; Chen, X; Fang, F; Wang, Y, 2017) |
| "Non-melanoma skin cancer (NMSC) was previously reported in 51." | 1.43 | Actinic keratosis: a cross-sectional study of disease characteristics and treatment patterns in Danish dermatology clinics. ( Egekvist, H; Erlendsson, AM; Haedersdal, M; Lorentzen, HF; Philipsen, PA; Stausbøl-Grøn, B; Stender, IM, 2016) |
| "The human squamous carcinoma cell line, SCL-1, was either untreated or treated with various combinations of ALA, PDT light source and inhibitors of MAPK signaling components." | 1.43 | Inhibition of MAPK signaling pathways enhances cell death induced by 5-Aminolevulinic acid-photodynamic therapy in skin squamous carcinoma cells. ( Ge, X; Jiao, Y; Jing, L; Li, PA; Liu, J; Shi, Z; Wang, Y; Yu, N; Zhang, X, 2016) |
| "Due to the unique location of the squamous cell carcinoma (SCC) of the lip, using a single method such as extended resection or radiotherapy probably causes morphological and functional defects." | 1.43 | Surgery combined with topical photodynamic therapy for the treatment of squamous cell carcinoma of the lip. ( Lu, Y; Wang, Y; Yang, Y, 2016) |
| "The PDT combined with a topical photosensitizer 5-aminolevulinic acid (ALA) and an intravenously injected light-sensitive agent hematoporphyrin derivative (HPD) was used to treat 26 patients with 41 skin cancer lesions in head and face." | 1.43 | A photodynamic therapy combined with topical 5-aminolevulinic acid and systemic hematoporphyrin derivative is more efficient but less phototoxic for cancer. ( Lin, Y; Wang, Y; Zhang, HG; Zhu, J, 2016) |
| " So we used surgery combined with topical photodynamic therapy (PDT) to treat SCC of the lip." | 1.43 | Surgery combined with topical photodynamic therapy for the treatment of squamous cell carcinoma of the lip. ( Lu, Y; Wang, Y; Yang, Y, 2016) |
| "Perianal squamous cell carcinoma in situ (SCCIS) is a relatively rare intraepidermal neoplasm that has the potential to progress to invasive squamous cell carcinoma." | 1.40 | Combination therapy for perianal squamous cell carcinoma in situ with imiquimod and photodynamic therapy. ( Bontumasi, NM; Hurst, EA; Sheinbein, D, 2014) |
| "Human head and neck cancer cells AMC-HN3 were treated with cisplatin- and ALA-mediated PDT individually, and also in combination." | 1.40 | Cisplatin enhances the efficacy of 5-aminolevulinic acid mediated photodynamic therapy in human head and neck squamous cell carcinoma. ( Ahn, JC; Biswas, R; Chung, PS; Lee, YK; Mondal, A, 2014) |
| "Cutaneous squamous cell carcinoma (cSCC) usually has ill-defined margins because of its irregular invasive patterns." | 1.39 | Efficacy of photodynamic diagnosis-guided Mohs micrographic surgery in primary squamous cell carcinoma. ( Jeon, SY; Kim, KH; Song, KH, 2013) |
| "Actinic keratosis is one of the most commonly treated skin conditions." | 1.38 | The interpretation of clinical studies on the photodynamic treatment of actinic keratosis. ( Kelleher, DK; Piazena, H, 2012) |
| "5-Aminolevulinic acid (ALA) has been used as a photodynamic sensitizer for cancer treatment using photodynamic therapy." | 1.37 | Apoptosis of SAS cells induced by sonodynamic therapy using 5-aminolevulinic acid sonosensitizer. ( Cao, W; Cui, H; Song, W; Zhang, R; Zheng, J, 2011) |
| "Calcitriol-pretreated tumors underwent enhanced apoptotic cell death after ALA-based PDT." | 1.37 | Vitamin D3 enhances the apoptotic response of epithelial tumors to aminolevulinate-based photodynamic therapy. ( Anand, S; Hasan, T; Maytin, EV; Wilson, C, 2011) |
| "Using mouse models of squamous cell skin cancer for preclinical proof of concept, we showed that calcitriol, delivered topically or intraperitoneally, increased tumoral accumulation of the PDT-activated ALA product protoporphyrin-IX (PpIX) up to 10-fold, mainly by altering expression of the porphyrin-synthesis enzymes coproporphyrinogen oxidase (increased) and ferrochelatase (decreased)." | 1.37 | Vitamin D3 enhances the apoptotic response of epithelial tumors to aminolevulinate-based photodynamic therapy. ( Anand, S; Hasan, T; Maytin, EV; Wilson, C, 2011) |
| "After transplanting five human oral squamous carcinoma cell lines into scid mice, the degree of tumor differentiation was evaluated by hematoxylin-and-eosin staining." | 1.35 | [Fluorescence analysis of oral squamous cell carcinoma with 5-aminolevulinic acid labeling]. ( Uekusa, M, 2009) |
| "Calcitriol pretreatment of the cells elevated their PpIX levels." | 1.35 | Calcitriol treatment improves methyl aminolaevulinate-based photodynamic therapy in human squamous cell carcinoma A431 cells. ( Cicarma, E; Juzeniene, A; Ma, LW; Moan, J; Tuorkey, M, 2009) |
| "They included squamous cell carcinoma (SCC), basal cell carcinoma (BCC), Bowen's disease (BD), mammary and extramammary Paget disease, actinic keratosis (AK) and erythroplasia of Queyrat." | 1.35 | Treatment of skin cancer and pre-cancer using topical ALA-PDT--a single hospital experience. ( Guo, MX; Wang, HW; Wang, XL; Xu, SZ, 2008) |
| "Etretinate-pretreated cells underwent apoptosis in response to ALA-based PDT." | 1.35 | Etretinate enhances the susceptibility of human skin squamous cell carcinoma cells to 5-aminolaevulic acid-based photodynamic therapy. ( Akita, Y; Ishida, N; Kuhara, T; Matsumoto, Y; Nakano, A; Takeo, T; Tamada, Y; Watanabe, D; Yamashita, N; Yanagishita, T, 2009) |
| "For optimal treatment of nonmelanoma skin cancer, actinic keratoses and other dermatoses improvements are required because of adverse side effects, which include pruritus, erythema, edema, and pain." | 1.35 | Effect of (R)L-sulforaphane on 5-aminolevulinic acid-mediated photodynamic therapy. ( Juzeniene, A; Mikolajewska, P; Moan, J, 2008) |
| "Patients who have had one oral cancer are at increased risk of developing a further malignant tumour, the detection of which is made difficult (and is often delayed) by the innocuous appearance of the early oral lesion." | 1.35 | Detection of mucosal abnormalities in patients with oral cancer using a photodynamic technique: A pilot study. ( Day, A; Goodman, CR; McLaren, S; O'Dwyer, M; Ogden, GR; Padgett, M, 2008) |
| "(R)L-sulforaphane (SF) is a compound that protects against erythema, but it can also induce DNA fragmentation that leads to cell death by apoptosis." | 1.35 | Effect of (R)L-sulforaphane on 5-aminolevulinic acid-mediated photodynamic therapy. ( Juzeniene, A; Mikolajewska, P; Moan, J, 2008) |
| "So far, we have treated 76 cases of skin cancer and pre-cancer using topical ALA-PDT." | 1.35 | Treatment of skin cancer and pre-cancer using topical ALA-PDT--a single hospital experience. ( Guo, MX; Wang, HW; Wang, XL; Xu, SZ, 2008) |
| "The concept of skin cancer prevention with photodynamic therapy has evolved over the past few years to include large surface application of aminolevulinic acid or methyl aminolevulinate followed by light exposure to prevent the development of new lesions." | 1.34 | Chemopreventative thoughts for photodynamic therapy. ( Bissonnette, R, 2007) |
| "Using h-ALA, the peak concentration of protoporphyrin IX, compared to ALA, is achieved 20% percent more quickly and with twice as much contrast between tumorous and healthy tissue (1:11 compared and 1:5, respectively)." | 1.33 | Pharmacokinetics of the photosensitizers aminolevulinic acid and aminolevulinic acid hexylester in oro-facial tumors embedded in the chorioallantois membrane of a hen's egg. ( Foth, HJ; Hoppenheit, C; Hüttenberger, D; Müller-Richter, UD; Reichert, TE; Spitzer, WJ, 2006) |
| "Early superficial (< 3 mm) squamous cell carcinomas of the esophagus can be ablated completely by 5-ALA-PDT." | 1.33 | Long-Segment early squamous cell carcinoma of the proximal esophagus: curative treatment and long-term follow-up after 5-aminolevulinic acid (5-ALA)-photodynamic therapy. ( Alsenbesy, M; Eickhoff, A; Eickhoff, JC; Hartmann, D; Jakobs, R; Riemann, JF; Schilling, D; Weickert, U, 2006) |
| " Using h-ALA, the peak concentration of protoporphyrin IX was achieved 20%-25% more quickly with 3- or 6-mM solutions than with ALA." | 1.33 | Pharmacokinetics of the photosensitizers aminolevulinic acid and aminolevulinic acid hexylester in oro-facial tumors embedded in the chorioallantois membrane of a hen's egg. ( Foth, HJ; Hoppenheit, C; Hüttenberger, D; Müller-Richter, UD; Reichert, TE; Spitzer, WJ, 2006) |
| "5-aminolevulinic acid (5-ALA) is a precursor in synthesis of endogenous porphyrins used to sensitize tumor tissues in photodynamic therapy (PDT)." | 1.32 | Enhancement of photodynamic therapy by use of aminolevulinic acid/glycolic acid drug mixture. ( Bronowicz, A; Oremek, G; Osiecka, BJ; Saleh, Y; Siewinski, M; Symonowicz, K; Ziolkowski, P, 2004) |
| "A 55-year-old man presented a squamous cell carcinoma (SCC) of 8 mm diameter, localized in the middle third of the lower eyelid, 3 mm under the eyelid margin on the eyelids." | 1.32 | Squamous cell carcinoma of the eyelid treated with photodynamic therapy. ( Campolmi, P; Cappuccini, A; Cappugi, P; Mavilia, L; Mori, M; Puccioni, M; Reali, EF; Rossi, R, 2004) |
| "Hypericin is a very promising new photosensitizer for innovative photodynamic therapy of esophageal cancer." | 1.32 | Hypericin activated by an incoherent light source has photodynamic effects on esophageal cancer cells. ( Höpfner, M; Kashtan, H; Lenz, M; Maaser, K; Riecken, EO; Scherübl, H; Sutter, AP; Theiss, A; von Lampe, B; Zeitz, M, 2003) |
| "It will be the aim of further investigations to verify the optimal time of incubation and dosing of systemical 5-ALA application to enhance fluorescence contrasts and set the basis for fluorescence guided resections." | 1.31 | [Fluorescence staining of oral and laryngeal cancer after application of 5-aminolevulinic acid]. ( Baumgartner, R; Betz, CS; Heinrich, P; Janda, P; Leunig, A, 2002) |
| "It is a new alternative modality for skin cancer therapies." | 1.31 | Evaluation of photodynamic therapy of skin cancers with partial differential alpha-aminolevulinic acid. ( Wang, X; Xia, Y; Xu, S; Xu, W; Zhang, C, 2002) |
| " We have investigated the effect of 5-ALA mediated PDT in combination with gamma-irradiation on the colony forming ability of several human head and neck tumour cell lines." | 1.31 | Effect of photodynamic therapy in combination with ionizing radiation on human squamous cell carcinoma cell lines of the head and neck. ( Allman, R; Cowburn, P; Mason, M, 2000) |
| "A total of 13 squamous cell carcinomas were treated, including 10 nasal planum lesions, two pinnal lesions and one eyelid lesion." | 1.31 | Photodynamic therapy of feline superficial squamous cell carcinoma using topical 5-aminolaevulinic acid. ( Dobson, JM; Langmack, K; Stell, AJ, 2001) |
| "Of our own patients suffering from oral squamous cell carcinoma (OSCC), 96% possessed a 5-aminolevulinic acid (ALA)-induced tumor fluorescence." | 1.31 | [Experimental 5-aminolevulinic acid-induced photodynamic therapy (ALA-PDT) of oral carcinomas. Procedures in treatment of solid tumors and elucidation of cell death]. ( Berndt, A; Dahse, R; Hyckel, P; Kosmehl, H; Schleier, P; Zenk, W, 2001) |
| "24 patients suffering from oral cancer were included in this investigation." | 1.31 | Fluorescence staining of oral cancer using a topical application of 5-aminolevulinic acid: fluorescence microscopic studies. ( Arbogast, S; Baumgartner, R; Betz, C; Grevers, G; Leunig, A; Mehlmann, M; Stepp, H, 2001) |
| "In mice with squamous cell carcinoma, the in vivo expression of PpIX in the tumors was highest with ALA methyl ester, which was 1." | 1.31 | In vitro and in vivo expression of protoporphyrin IX induced by lipophilic 5-aminolevulinic acid derivatives. ( Ishibashi, A; Itoh, Y; Ninomiya, Y; Tajima, S, 2001) |
| "PDT of Barrett's esophagus with severe dysplasia, or of mucosal carcinomas and superficial squamous-cell cancer of the esophagus, requires light application devices allowing homogeneous illumination of the tissue surface in spite of esophageal motility and respiratory movement." | 1.30 | A new long-range through-the-scope balloon applicator for photodynamic therapy in the esophagus and cardia. ( Ell, C; Gossner, L; May, A; Sroka, R, 1999) |
| "4 had squamous cell carcinoma of the mid-esophagus and 4 had adenocarcinoma of the lower esophagus." | 1.30 | [Photodynamic therapy for dysphagia due to esophageal carcinoma]. ( Haddad, R; Halpern, Z; Kashtan, H; Konikoff, F; Skornick, Y; Umansky, M, 1999) |
| "The degree of dysphagia was recorded before and 14 days after treatment." | 1.30 | [Photodynamic therapy for dysphagia due to esophageal carcinoma]. ( Haddad, R; Halpern, Z; Kashtan, H; Konikoff, F; Skornick, Y; Umansky, M, 1999) |
| "Dysphagia was improved in all except 1 patient." | 1.30 | [Photodynamic therapy for dysphagia due to esophageal carcinoma]. ( Haddad, R; Halpern, Z; Kashtan, H; Konikoff, F; Skornick, Y; Umansky, M, 1999) |
| "Two invasive cervical cancer cell lines were used, C33 and SIHA." | 1.29 | [The synergistic effect of delta-aminolevulinic acid and photodynamic laser therapy based on an in vitro model of the ATP tumor chemosensitivity test]. ( Hepp, H; Kirschstein, M; Korell, M; Untch, M, 1995) |
| "Protoporphyrin IX fluorescence was detected in the oral mucosa of all patients after local application of 5-ALA." | 1.29 | Fluorescence imaging and spectroscopy of 5-aminolevulinic acid induced protoporphyrin IX for the detection of neoplastic lesions in the oral cavity. ( Alwin, G; Baumgartner, R; Feyh, J; Gutmann, R; Leunig, A; Rick, K; Stepp, H, 1996) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 34 (15.38) | 18.2507 |
| 2000's | 63 (28.51) | 29.6817 |
| 2010's | 83 (37.56) | 24.3611 |
| 2020's | 41 (18.55) | 2.80 |
| Authors | Studies |
|---|---|
| Yao, Y | 1 |
| Shi, L | 9 |
| Wang, Y | 7 |
| Shen, X | 2 |
| Ye, S | 1 |
| Tang, G | 1 |
| Wu, L | 1 |
| Beika, M | 2 |
| Harada, Y | 2 |
| Minamikawa, T | 1 |
| Yamaoka, Y | 1 |
| Koizumi, N | 1 |
| Murayama, Y | 1 |
| Konishi, H | 1 |
| Shiozaki, A | 1 |
| Fujiwara, H | 1 |
| Otsuji, E | 1 |
| Takamatsu, T | 2 |
| Tanaka, H | 1 |
| Lv, T | 3 |
| Huang, J | 1 |
| Wu, M | 1 |
| Wang, H | 5 |
| Zeng, Q | 6 |
| Wang, X | 30 |
| Wang, J | 2 |
| Wang, K | 1 |
| Liang, J | 1 |
| Jin, J | 2 |
| Yan, S | 1 |
| Shen, S | 2 |
| Liu, X | 5 |
| Yang, X | 1 |
| Hu, C | 2 |
| Wang, P | 14 |
| He, X | 1 |
| Hu, N | 1 |
| Yang, S | 2 |
| Yang, Z | 1 |
| Hu, L | 1 |
| Wen, N | 1 |
| Tang, Y | 2 |
| Su, Y | 1 |
| Xu, Y | 1 |
| Zhang, Y | 4 |
| Shen, Y | 1 |
| Qin, L | 1 |
| Zhang, L | 11 |
| Cao, L | 1 |
| Zhou, Y | 1 |
| Zhang, T | 1 |
| Zhang, M | 1 |
| Fang, S | 2 |
| Wu, Y | 2 |
| Zhang, H | 9 |
| Yan, G | 2 |
| Zhang, G | 12 |
| Mendonca, P | 1 |
| Sunny, SP | 1 |
| Mohan, U | 1 |
| Birur N, P | 1 |
| Suresh, A | 1 |
| Kuriakose, MA | 1 |
| Che, Q | 1 |
| Huang, X | 1 |
| Li, C | 1 |
| Li, J | 3 |
| Jiang, L | 1 |
| Zeng, K | 1 |
| Cheng, B | 1 |
| Veerabagu, S | 1 |
| Miller, CJ | 1 |
| Sobanko, JF | 1 |
| Shin, TM | 1 |
| Higgins, HW | 1 |
| Giordano, CN | 1 |
| Etzkorn, JR | 1 |
| Nicolás-Morala, J | 1 |
| Portillo-Esnaola, M | 1 |
| Terrén, S | 1 |
| Gutiérrez-Pérez, M | 1 |
| Gilaberte, Y | 2 |
| González, S | 1 |
| Juarranz, Á | 2 |
| Ye, T | 2 |
| Li, D | 1 |
| Yang, L | 2 |
| Jiang, B | 2 |
| Chen, B | 2 |
| Zou, Y | 2 |
| Yu, B | 2 |
| Schary, N | 1 |
| Novak, B | 3 |
| Kämper, L | 1 |
| Yousf, A | 1 |
| Lübbert, H | 1 |
| Liu, J | 3 |
| Zhou, Z | 4 |
| Shim, PJ | 3 |
| Zeitouni, NC | 5 |
| Zhang, J | 4 |
| Feng, Q | 1 |
| Xiao, J | 1 |
| Lin, J | 1 |
| Nestor, MS | 1 |
| Han, H | 1 |
| Ceci, FM | 1 |
| Lawson, A | 1 |
| Gade, A | 1 |
| Chen, D | 1 |
| Wang, B | 1 |
| Zhao, Z | 4 |
| Lai, M | 1 |
| Pampena, R | 1 |
| Cornacchia, L | 1 |
| Pellacani, G | 1 |
| Peris, K | 2 |
| Longo, C | 1 |
| Ji, Z | 3 |
| Hellen, R | 1 |
| Nic Dhonncha, E | 1 |
| Havelin, A | 1 |
| Fleming, L | 1 |
| Kavanagh, A | 1 |
| Lally, A | 1 |
| Kirby, B | 1 |
| Moriarty, B | 1 |
| Collins, P | 1 |
| Kibbi, N | 1 |
| Leffell, DJ | 1 |
| Christensen, SR | 1 |
| Ma, J | 1 |
| Salvio, AG | 1 |
| Stringasci, MD | 1 |
| Barreto Requena, M | 1 |
| Bagnato, VS | 1 |
| Dong, L | 1 |
| Li, X | 3 |
| Zhang, W | 1 |
| Lu, Y | 2 |
| Andreadis, D | 1 |
| Pavlou, A- | 1 |
| Vakirlis, E | 2 |
| Anagnostou, E | 1 |
| Vrani, F | 2 |
| Poulopoulos, A | 1 |
| Kolokotronis, A | 1 |
| Ioannidis, D | 1 |
| Sotiriou, E | 4 |
| Ji, J | 7 |
| Li, M | 1 |
| Khan, S | 1 |
| Hussain, MAB | 1 |
| Khan, AP | 2 |
| Liu, H | 4 |
| Siddiqui, S | 1 |
| Mallidi, S | 2 |
| Leon, P | 1 |
| Daly, L | 2 |
| Rudd, G | 2 |
| Cuckov, F | 2 |
| Hopper, C | 3 |
| Bown, SG | 3 |
| Akhtar, K | 1 |
| Hasan, SA | 1 |
| Siddiqui, SA | 1 |
| Hasan, T | 5 |
| Celli, JP | 2 |
| León, D | 1 |
| Buchegger, K | 1 |
| Silva, R | 1 |
| Riquelme, I | 1 |
| Viscarra, T | 1 |
| Mora-Lagos, B | 1 |
| Zanella, L | 1 |
| Schafer, F | 1 |
| Kurachi, C | 1 |
| Roa, JC | 1 |
| Ili, C | 1 |
| Brebi, P | 1 |
| Zhang, GL | 1 |
| Keyal, U | 2 |
| Wang, PR | 1 |
| Zhang, LL | 1 |
| Bhatta, AK | 3 |
| Wu, YH | 1 |
| Wang, XL | 2 |
| Yan, J | 1 |
| Li, L | 1 |
| Chen, T | 1 |
| Anand, S | 2 |
| Govande, M | 1 |
| Yasinchak, A | 1 |
| Heusinkveld, L | 1 |
| Shakya, S | 1 |
| Fairchild, RL | 1 |
| Maytin, EV | 3 |
| Heron, CE | 1 |
| Feldman, SR | 1 |
| Li, S | 2 |
| Zhu, L | 4 |
| Cervantes, JA | 1 |
| Zhao, Y | 1 |
| Sun, X | 1 |
| Peng, J | 1 |
| Feng, W | 1 |
| Luo, X | 1 |
| Wang, T | 1 |
| Xiang, W | 1 |
| Dai, Y | 1 |
| Zhu, J | 2 |
| Zheng, J | 3 |
| Gondivkar, SM | 1 |
| Gadbail, AR | 1 |
| Choudhary, MG | 1 |
| Vedpathak, PR | 1 |
| Likhitkar, MS | 1 |
| Bu, W | 1 |
| Chen, X | 1 |
| Fang, F | 2 |
| Wollina, U | 1 |
| Gaber, B | 1 |
| Koch, A | 1 |
| Rybarski, M | 1 |
| Schmitz, L | 1 |
| Dirschka, T | 2 |
| Miola, AC | 1 |
| Ferreira, ER | 1 |
| Lima, TRR | 1 |
| Schmitt, JV | 1 |
| Abbade, LPF | 1 |
| Miot, HA | 1 |
| Lazaridou, E | 1 |
| Sideris, N | 1 |
| Kirmanidou, E | 1 |
| Apalla, Z | 3 |
| Lallas, A | 1 |
| Ioannides, D | 3 |
| Jia, QN | 1 |
| Nguyen, GH | 1 |
| Fang, K | 1 |
| Jin, HZ | 1 |
| Zeng, YP | 1 |
| Fan, Z | 3 |
| Yang, D | 2 |
| Bahavar, CF | 1 |
| Zhou, F | 3 |
| Chen, WR | 3 |
| Austin, E | 1 |
| Koo, E | 1 |
| Jagdeo, J | 1 |
| Liu, Y | 1 |
| Rosin, FCP | 1 |
| Teixeira, MG | 1 |
| Pelissari, C | 1 |
| Corrêa, L | 3 |
| Shivashankarappa, A | 1 |
| Sanjay, KR | 1 |
| Reinhold, U | 1 |
| Petering, H | 1 |
| Rozsondai, A | 1 |
| Gille, J | 1 |
| Kurzen, H | 1 |
| Ostendorf, R | 1 |
| Ebeling, A | 1 |
| Stocker, M | 1 |
| Radny, P | 1 |
| Gellén, E | 1 |
| Fidrus, E | 1 |
| Péter, M | 1 |
| Szegedi, A | 1 |
| Emri, G | 1 |
| Remenyik, É | 1 |
| Mei, LH | 1 |
| Yang, G | 3 |
| Zhou, Q | 1 |
| Zheng, Z | 1 |
| Zhou, W | 1 |
| Zhang, S | 1 |
| Li, Z | 2 |
| Zhao, J | 1 |
| Buchner, A | 1 |
| Pohla, H | 1 |
| Pongratz, T | 1 |
| Rühm, A | 1 |
| Zimmermann, W | 1 |
| Gederaas, OA | 1 |
| Stepp, H | 6 |
| Sroka, R | 5 |
| Teoh, YL | 1 |
| Kuan, LY | 1 |
| Chong, WS | 1 |
| Chia, HY | 1 |
| Thng, TGS | 1 |
| Chuah, SY | 1 |
| Tu, Q | 2 |
| Huang, Z | 3 |
| Cinotti, E | 1 |
| Perrot, JL | 1 |
| Labeille, B | 1 |
| Douchet, C | 1 |
| Mottet, N | 1 |
| Cambazard, F | 1 |
| Yamamoto, M | 1 |
| Fujita, H | 1 |
| Katase, N | 1 |
| Inoue, K | 1 |
| Nagatsuka, H | 1 |
| Utsumi, K | 1 |
| Sasaki, J | 1 |
| Ohuchi, H | 1 |
| Ahn, JC | 1 |
| Biswas, R | 1 |
| Mondal, A | 1 |
| Lee, YK | 1 |
| Chung, PS | 1 |
| Lee, PK | 2 |
| Kloser, A | 1 |
| Togsverd-Bo, K | 3 |
| Lerche, CM | 3 |
| Philipsen, PA | 2 |
| Hædersdal, M | 1 |
| Wulf, HC | 2 |
| Jeon, SY | 1 |
| Kim, KH | 3 |
| Song, KH | 2 |
| Asai, J | 1 |
| Takenaka, H | 1 |
| Katoh, N | 1 |
| Yang, DF | 1 |
| Lee, JW | 1 |
| Chen, HM | 1 |
| Hsu, YC | 1 |
| Xie, H | 1 |
| Xie, Z | 1 |
| Mousavi, M | 1 |
| Bendsoe, N | 1 |
| Brydegaard, M | 1 |
| Axelsson, J | 1 |
| Andersson-Engels, S | 1 |
| Calista, D | 2 |
| Bardazzi, F | 1 |
| Loi, C | 1 |
| Magnano, M | 1 |
| Burtica, EC | 1 |
| Giordano, F | 1 |
| Patrizi, A | 1 |
| Dixon, AJ | 1 |
| Anderson, SJ | 1 |
| Mazzurco, JD | 1 |
| Steinman, HK | 1 |
| Liang, WM | 1 |
| Theng, TS | 1 |
| Lim, KS | 1 |
| Tan, WP | 1 |
| Fargnoli, MC | 1 |
| Kostaki, D | 1 |
| Piccioni, A | 1 |
| Di Stefani, A | 1 |
| Bontumasi, NM | 1 |
| Sheinbein, D | 1 |
| Hurst, EA | 1 |
| Zhao, F | 1 |
| Luan, H | 1 |
| Fluehler, C | 1 |
| Colli, C | 1 |
| Gatti, A | 1 |
| Trevisan, G | 1 |
| Erlendsson, AM | 1 |
| Egekvist, H | 1 |
| Lorentzen, HF | 1 |
| Stausbøl-Grøn, B | 1 |
| Stender, IM | 1 |
| Haedersdal, M | 3 |
| Lin, Y | 1 |
| Zhang, HG | 1 |
| Qiao, L | 1 |
| Xu, C | 1 |
| Li, Q | 2 |
| Mei, Z | 1 |
| Cai, H | 1 |
| Liu, W | 1 |
| Bay, C | 1 |
| Ahn, PH | 1 |
| Quon, H | 1 |
| O'Malley, BW | 1 |
| Weinstein, G | 1 |
| Chalian, A | 1 |
| Malloy, K | 1 |
| Atkins, JH | 1 |
| Sollecito, T | 1 |
| Greenberg, M | 1 |
| McNulty, S | 1 |
| Lin, A | 1 |
| Zhu, TC | 1 |
| Finlay, JC | 1 |
| Cengel, K | 1 |
| Livolsi, V | 1 |
| Feldman, M | 1 |
| Mick, R | 1 |
| Busch, TM | 1 |
| Lima, CA | 2 |
| Goulart, VP | 2 |
| Zezell, DM | 2 |
| Peteja, M | 1 |
| Brueck, T | 1 |
| Luebbert, H | 1 |
| Ge, X | 1 |
| Shi, Z | 1 |
| Jing, L | 1 |
| Yu, N | 1 |
| Zhang, X | 1 |
| Jiao, Y | 1 |
| Li, PA | 1 |
| Yang, Y | 2 |
| Maranda, EL | 1 |
| Nguyen, AH | 1 |
| Lim, VM | 1 |
| Shah, VV | 1 |
| Jimenez, JJ | 1 |
| Rossi, A | 1 |
| Garelli, V | 1 |
| Pranteda, G | 1 |
| Cardone, M | 1 |
| Anzalone, A | 1 |
| Fortuna, MC | 1 |
| Di Nunno, D | 1 |
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| De Vita, G | 1 |
| Carlesimo, M | 1 |
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| de Souza, AL | 1 |
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| Kleinpenning, MM | 3 |
| van de Kerkhof, PC | 3 |
| Gerritsen, RM | 2 |
| Chovarda, E | 1 |
| Lefaki, I | 1 |
| Devliotou-Panagiotidou, D | 1 |
| Willey, A | 1 |
| Mehta, S | 1 |
| Moon, YH | 1 |
| Park, JH | 1 |
| Kim, SA | 1 |
| Lee, JB | 1 |
| Ahn, SG | 1 |
| Yoon, JH | 1 |
| Poulsen, T | 1 |
| Liutkeviciūte-Navickiene, J | 1 |
| Mordas, A | 1 |
| Simkute, S | 1 |
| Bloznelyte-Plesniene, L | 1 |
| Good, LM | 1 |
| Miller, MD | 1 |
| High, WA | 1 |
| Mallia, RJ | 1 |
| Subhash, N | 1 |
| Sebastian, P | 1 |
| Kumar, R | 1 |
| Thomas, SS | 1 |
| Mathews, A | 1 |
| Madhavan, J | 1 |
| Lee, CY | 1 |
| Kim, YH | 1 |
| Fasanmade, A | 1 |
| Milne, J | 1 |
| Taylor, D | 1 |
| Godden, D | 1 |
| Gao, T | 1 |
| Long, HA | 1 |
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| Wolberink, EW | 1 |
| Smits, T | 2 |
| Blokx, WA | 2 |
| van Erp, PE | 2 |
| Song, W | 2 |
| Cui, H | 1 |
| Zhang, R | 1 |
| Cao, W | 2 |
| Tierney, E | 1 |
| Petersen, J | 1 |
| Hanke, CW | 1 |
| Milla, LN | 1 |
| Cogno, IS | 1 |
| Rodríguez, ME | 1 |
| Sanz-Rodríguez, F | 1 |
| Zamarrón, A | 1 |
| Carrasco, E | 1 |
| Rivarola, VA | 1 |
| Kraft, M | 1 |
| Betz, CS | 4 |
| Leunig, A | 7 |
| Arens, C | 1 |
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| Mason, MN | 1 |
| Wing, G | 1 |
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| Flaherty, KT | 1 |
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| Lin, JY | 1 |
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| Nolan, KA | 1 |
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| Lv, Y | 1 |
| Fang, M | 1 |
| Yang, B | 1 |
| Li, H | 1 |
| Xiuzigao, Z | 1 |
| Chen, Y | 1 |
| Gaál, M | 1 |
| Kui, R | 1 |
| Hunyadi, Z | 1 |
| Kemény, L | 1 |
| Gyulai, R | 1 |
| Kelleher, DK | 1 |
| Piazena, H | 1 |
| Xu, S | 2 |
| Xu, W | 1 |
| Xia, Y | 1 |
| Zhang, C | 1 |
| Zheng, W | 1 |
| Soo, KC | 1 |
| Sivanandan, R | 1 |
| Olivo, M | 1 |
| Frimberger, D | 1 |
| Schneede, P | 1 |
| Hungerhuber, E | 1 |
| Zaak, D | 1 |
| Siebels, M | 1 |
| Hofstetter, A | 1 |
| Verwanger, T | 1 |
| Sanovic, R | 1 |
| Aberger, F | 1 |
| Frischauf, AM | 1 |
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| Janda, P | 2 |
| Baumgartner, R | 6 |
| Ebihara, A | 2 |
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| Fago, S | 1 |
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| Osann, K | 2 |
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| Krasieva, T | 1 |
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| Theiss, A | 1 |
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| Sutter, AP | 1 |
| Kashtan, H | 3 |
| von Lampe, B | 1 |
| Riecken, EO | 1 |
| Zeitz, M | 1 |
| Scherübl, H | 1 |
| Oseroff, AR | 2 |
| Shieh, S | 1 |
| Brown, SB | 2 |
| Foley, P | 2 |
| Morton, CA | 2 |
| Silapunt, S | 1 |
| Goldberg, LH | 1 |
| Alam, M | 1 |
| Kormeili, T | 1 |
| Yamauchi, PS | 1 |
| Lowe, NJ | 1 |
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| Bouwes Bavinck, JN | 1 |
| Shahzidi, S | 1 |
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| Suo, Z | 2 |
| Nesland, JM | 2 |
| Peng, Q | 2 |
| Oseroff, A | 1 |
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| Morton, C | 1 |
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| Ogasawara, T | 1 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Randomised Trial Comparing Methyl Aminolaevulinate Photodynamic Therapy With and Without Ablative Fractional Laser Treatment in Patients With Microinvasive Squamous Cell Carcinoma: Results From a 24-month Follow-up[NCT02666534] | Phase 1 | 45 participants (Actual) | Interventional | 2012-01-31 | Completed | ||
| A Single Center Phase II Trial of Vemurafenib (R05185426) in Poor Performance Status Patients With Unresectable Locally Advanced or Metastatic Melanoma Harboring a V600E/K Mutation[NCT01474551] | Phase 2 | 2 participants (Actual) | Interventional | 2011-11-30 | Terminated (stopped due to Lack of accrual) | ||
| Evaluation of the Formulation of 5-aminolevulinic Acid With Dimethylsulfoxide in Photodynamic Therapy for Treatment of Actinic Keratosis[NCT01459393] | Phase 3 | 137 participants (Actual) | Interventional | 2010-11-30 | Completed | ||
| Photodynamic Therapy for Treatment of Cutaneous Squamous Cell Carcinoma in Situ[NCT03025724] | 40 participants (Anticipated) | Interventional | 2017-01-31 | Not yet recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
The Response Evaluation Criteria in Solid Tumors (RECIST) v1.1 will be used to determine treatment response. In order to be considered evaluable for response, a patient must have completed at least 1 cycle of therapy. Patients who do not complete a cycle of therapy can be replaced. (NCT01474551)
Timeframe: 2 years
| Intervention | participants (Number) | |||
|---|---|---|---|---|
| Stable Disease | Complete Response | Partial Response | Progression of Disease | |
| Vemurafenib | 1 | 0 | 0 | 0 |
25 reviews available for aminolevulinic acid and Carcinoma, Epidermoid
| Article | Year |
|---|---|
Non-invasive imaging of oral potentially malignant and malignant lesions: A systematic review and meta-analysis.
Topics: Aminolevulinic Acid; Carcinoma, Squamous Cell; Humans; Mouth Diseases; Mouth Neoplasms; Narrow Band | 2022 |
Treatments of actinic cheilitis: A systematic review of the literature.
Topics: Aminolevulinic Acid; Carcinoma, Squamous Cell; Cheilitis; Combined Modality Therapy; Dermabrasion; D | 2020 |
Photodynamic treatment outcomes of potentially-malignant lesions and malignancies of the head and neck region: A systematic review.
Topics: Aminolevulinic Acid; Carcinoma, Squamous Cell; Chlorophyllides; Databases, Factual; Dihematoporphyri | 2018 |
Daylight photodynamic therapy for field cancerization: lessons from molecular biology.
Topics: Aminolevulinic Acid; Carcinoma, Squamous Cell; Humans; Keratosis, Actinic; Light; Pain; Photochemoth | 2018 |
Immunological effects of photodynamic therapy in the treatment of actinic keratosis and squamous cell carcinoma.
Topics: Adaptive Immunity; Alarmins; Aminolevulinic Acid; Carcinoma, Squamous Cell; Dendritic Cells; Humans; | 2018 |
Current methods for photodynamic therapy in the US: comparison of MAL/PDT and ALA/PDT.
Topics: Aminolevulinic Acid; Carcinoma, Squamous Cell; Disease Progression; Humans; Keratosis, Actinic; Phot | 2013 |
Photodynamic therapy for the treatment of microinvasive squamous cell carcinoma of the lower lip: a case report.
Topics: Aged; Aminolevulinic Acid; Carcinoma, Squamous Cell; Cheilitis; Dermoscopy; Humans; Lip Neoplasms; M | 2015 |
Erythroplasia of Queyrat treated by laser and light modalities: a systematic review.
Topics: Aminolevulinic Acid; Carcinoma, Squamous Cell; Humans; Lasers, Gas; Lasers, Solid-State; Low-Level L | 2016 |
Intralesional agents in the management of cutaneous malignancy: a review.
Topics: Aminolevulinic Acid; Antibodies, Monoclonal, Murine-Derived; Antineoplastic Agents; Bleomycin; Carci | 2011 |
Value of fluorescence endoscopy for the early diagnosis of laryngeal cancer and its precursor lesions.
Topics: Aminolevulinic Acid; Carcinoma, Squamous Cell; Early Detection of Cancer; Endoscopy; Fluorescence; H | 2011 |
Nonmelanoma skin cancer chemoprevention.
Topics: Acitretin; Aminolevulinic Acid; Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents; Carc | 2011 |
[Fluorescence diagnosis of non-melanoma skin cancer].
Topics: Aminolevulinic Acid; Apoptosis; Carcinoma, Basal Cell; Carcinoma, Basosquamous; Carcinoma, Squamous | 2012 |
Photodynamic therapy for nonmelanoma skin cancers. Current review and update.
Topics: Aminolevulinic Acid; Bowen's Disease; Carcinoma, Basal Cell; Carcinoma, Squamous Cell; Dihematoporph | 2003 |
The role of light in the treatment of non-melanoma skin cancer using methyl aminolevulinate.
Topics: Aminolevulinic Acid; Carcinoma, Basal Cell; Carcinoma, Squamous Cell; Humans; Photochemotherapy; Ski | 2003 |
Clinical efficacy of methyl aminolevulinate (Metvix) photodynamic therapy.
Topics: Aminolevulinic Acid; Carcinoma, Basal Cell; Carcinoma, Squamous Cell; Clinical Trials, Phase III as | 2003 |
Methyl aminolevulinate (Metvix) photodynamic therapy - practical pearls.
Topics: Aminolevulinic Acid; Carcinoma, Basal Cell; Carcinoma, Squamous Cell; Humans; Photochemotherapy; Pra | 2003 |
Topical and light-based treatments for actinic keratoses.
Topics: Adjuvants, Immunologic; Administration, Topical; Aminolevulinic Acid; Aminoquinolines; Antineoplasti | 2003 |
Topical photodynamic therapy in clinical dermatology.
Topics: Adult; Aminolevulinic Acid; Carcinoma, Basal Cell; Carcinoma, Squamous Cell; Humans; Keratosis; Phot | 2004 |
Aminolevulinic acid photodynamic therapy for skin cancers.
Topics: Aminolevulinic Acid; Bowen's Disease; Carcinoma, Basal Cell; Carcinoma, Squamous Cell; Humans; Photo | 2007 |
Guidelines on the use of photodynamic therapy for nonmelanoma skin cancer: an international consensus. International Society for Photodynamic Therapy in Dermatology, 2005.
Topics: Aminolevulinic Acid; Australia; Basal Cell Nevus Syndrome; Bowen's Disease; Carcinoma, Basal Cell; C | 2007 |
[Medical treatment of epitheliomas].
Topics: Aged; Aged, 80 and over; Aminolevulinic Acid; Antineoplastic Agents; Bowen's Disease; Carcinoma; Car | 1997 |
Photodynamic therapy in dermatology.
Topics: Administration, Cutaneous; Aminolevulinic Acid; Carcinoma, Basal Cell; Carcinoma, Squamous Cell; Cel | 1998 |
Optimum porphyrin accumulation in epithelial skin tumours and psoriatic lesions after topical application of delta-aminolaevulinic acid.
Topics: Administration, Topical; Aminolevulinic Acid; Carcinoma, Basal Cell; Carcinoma, Squamous Cell; Human | 1999 |
Photodynamic therapy of early squamous cell cancers of the esophagus.
Topics: Aminolevulinic Acid; Antineoplastic Agents; Carcinoma, Squamous Cell; Dihematoporphyrin Ether; Drug | 2000 |
Role of lasers and photodynamic therapy in the treatment of cutaneous malignancy.
Topics: Aged; Aminolevulinic Acid; Bowen's Disease; Carcinoma, Basal Cell; Carcinoma, Squamous Cell; Clinica | 2001 |
24 trials available for aminolevulinic acid and Carcinoma, Epidermoid
| Article | Year |
|---|---|
Ablative fractional laser-assisted photodynamic therapy vs. ablative fractional laser for oral leukoplakia treatment: A randomized, controlled pilot study.
Topics: Aminolevulinic Acid; Carcinoma, Squamous Cell; Humans; Laser Therapy; Lasers, Solid-State; Leukoplak | 2021 |
Daylight photodynamic therapy for the management of actinic cheilitis.
Topics: Aged; Aged, 80 and over; Aminolevulinic Acid; Carcinoma, Squamous Cell; Cheilitis; Female; Follow-Up | 2020 |
A Clinical Trial Using Attrition Combined with 5-Aminolevulinic Acids Based Photodynamic Therapy in Treating Squamous Cell Carcinoma.
Topics: Aged; Aminolevulinic Acid; Apoptosis; Carcinoma, Squamous Cell; Combined Modality Therapy; Female; H | 2017 |
PHOTODYNAMIC TREATMENT WITH NANOEMULSIFIED 5-AMINOLEVULINIC ACID AND NARROW BAND RED LIGHT FOR FIELD CANCERIZATION DUE TO OCCUPATIONAL EXPOSURE TO ULTRAVIOLET LIGHT IRRADIATION.
Topics: Aged; Aged, 80 and over; Aminolevulinic Acid; Anti-Inflammatory Agents, Non-Steroidal; Carcinoma, Sq | 2018 |
Effectiveness and safety of 0·5% colchicine cream vs. photodynamic therapy with methyl aminolaevulinate in the treatment of actinic keratosis and skin field cancerization of the forearms: a randomized controlled trial.
Topics: Aged; Aminolevulinic Acid; Atrophy; Biopsy; Carcinoma, Squamous Cell; Colchicine; Disease Progressio | 2018 |
Short incubation fractional CO
Topics: Administration, Cutaneous; Aged; Aged, 80 and over; Aminolevulinic Acid; Carcinoma, Basal Cell; Carc | 2019 |
Novel photodynamic therapy does not prevent new skin cancers--randomized controlled trial.
Topics: Aged; Aminolevulinic Acid; Carcinoma, Basal Cell; Carcinoma, Squamous Cell; Facial Neoplasms; Female | 2014 |
Toxicities and early outcomes in a phase 1 trial of photodynamic therapy for premalignant and early stage head and neck tumors.
Topics: Aged; Aminolevulinic Acid; Carcinoma, Squamous Cell; Female; Head and Neck Neoplasms; Humans; Male; | 2016 |
Effect of Methyl Aminolevulinate Photodynamic Therapy With and Without Ablative Fractional Laser Treatment in Patients With Microinvasive Squamous Cell Carcinoma: A Randomized Clinical Trial.
Topics: Aged; Aged, 80 and over; Aminolevulinic Acid; Carcinoma, Squamous Cell; Female; Humans; Lasers, Soli | 2017 |
Skin cancer: preventive photodynamic therapy in patients with face and scalp cancerization. A randomized placebo-controlled study.
Topics: Aged; Aged, 80 and over; Aminolevulinic Acid; Carcinoma, Basal Cell; Carcinoma, Squamous Cell; Facia | 2010 |
Reduction in the incidence of squamous cell carcinoma in solid organ transplant recipients treated with cyclic photodynamic therapy.
Topics: Adult; Aged; Aminolevulinic Acid; Carcinoma, Squamous Cell; Female; Follow-Up Studies; Humans; Incid | 2010 |
Photodynamic therapy for multiple eruptive keratoacanthomas associated with vemurafenib treatment for metastatic melanoma.
Topics: Aged; Aminolevulinic Acid; Antineoplastic Agents; Carcinoma, Squamous Cell; Disease Progression; Dru | 2012 |
Excretion measurement of porphyrins and their precursors after topical administration of 5-aminolaevulinic acid for fluorescence endoscopy in head and neck cancer.
Topics: Administration, Topical; Aged; Aminolevulinic Acid; Carcinoma in Situ; Carcinoma, Squamous Cell; Fec | 2003 |
Photodynamic therapy does not prevent cutaneous squamous-cell carcinoma in organ-transplant recipients: results of a randomized-controlled trial.
Topics: Adult; Aged; Aminolevulinic Acid; Carcinoma, Squamous Cell; Female; Humans; Keratosis; Male; Middle | 2006 |
Comparison of topical methyl aminolevulinate photodynamic therapy with cryotherapy or Fluorouracil for treatment of squamous cell carcinoma in situ: Results of a multicenter randomized trial.
Topics: Administration, Cutaneous; Adult; Aged; Aged, 80 and over; Aminolevulinic Acid; Antimetabolites, Ant | 2006 |
Repetitive photodynamic therapy with topical delta-aminolaevulinic acid as an appropriate approach to the routine treatment of superficial non-melanoma skin tumours.
Topics: Administration, Topical; Adult; Aged; Aged, 80 and over; Aminolevulinic Acid; Carcinoma, Basal Cell; | 1995 |
Superficial photodynamic therapy with topical 5-aminolaevulinic acid for superficial primary and secondary skin cancer.
Topics: Adenocarcinoma; Administration, Topical; Aminolevulinic Acid; Bowen's Disease; Breast Neoplasms; Car | 1994 |
Long-term follow-up and histological changes of superficial nonmelanoma skin cancers treated with topical delta-aminolevulinic acid photodynamic therapy.
Topics: Administration, Topical; Aged; Aged, 80 and over; Aminolevulinic Acid; Antineoplastic Agents; Carcin | 1998 |
Photodynamic therapy of cancer of the esophagus using systemic aminolevulinic acid and a non laser light source: a phase I/II study.
Topics: Adenocarcinoma; Administration, Oral; Aged; Aged, 80 and over; Aminolevulinic Acid; Carcinoma, Squam | 1999 |
[Topical photodynamic therapy in basal and squamous cell carcinoma and penile Bowen's disease with 20% aminolevulinic acid, and exposure to red light and infrared light].
Topics: Administration, Topical; Adult; Aged; Aminolevulinic Acid; Bowen's Disease; Carcinoma, Basal Cell; C | 1998 |
Topical delta-aminolevulinic acid-based photodynamic therapy for Japanese actinic keratoses.
Topics: Aged; Aged, 80 and over; Aminolevulinic Acid; Arm; Asian People; Carcinoma, Squamous Cell; Facial De | 2000 |
Does new photosensitizer improve photodynamic therapy in advanced esophageal carcinoma?
Topics: Adenocarcinoma; Aged; Aged, 80 and over; Aminolevulinic Acid; Carcinoma, Squamous Cell; Deglutition | 2001 |
Comparison of 5-aminolaevulinic acid and porphyrin photosensitization for photodynamic therapy of malignant bronchial stenosis: a clinical pilot study.
Topics: Adenocarcinoma; Aged; Aminolevulinic Acid; Bronchial Diseases; Carcinoma, Squamous Cell; Constrictio | 2002 |
Photodynamic therapy with endogenous protoporphyrin IX: basic principles and present clinical experience.
Topics: Aminolevulinic Acid; Animals; Carcinoma, Basal Cell; Carcinoma, Squamous Cell; Humans; Keratosis; Ph | 1990 |
172 other studies available for aminolevulinic acid and Carcinoma, Epidermoid
| Article | Year |
|---|---|
Accumulation of Uroporphyrin I in Necrotic Tissues of Squamous Cell Carcinoma after Administration of 5-Aminolevulinic Acid.
Topics: Aged; Aminolevulinic Acid; Animals; Carcinoma, Squamous Cell; Cell Line, Tumor; Chromatography, High | 2021 |
Halofuginone enhances the anti-tumor effect of ALA-PDT by suppressing NRF2 signaling in cSCC.
Topics: Aminolevulinic Acid; Animals; Apoptosis; Carcinoma, Squamous Cell; Cell Line, Tumor; Mice; NF-E2-Rel | 2022 |
Chitosan-tripolyphosphate nanoparticles-mediated co-delivery of MTHFD1L shRNA and 5-aminolevulinic acid for combination photodynamic-gene therapy in oral cancer.
Topics: Aminolevulinic Acid; Animals; Carcinoma, Squamous Cell; Cell Line, Tumor; Chitosan; Genetic Therapy; | 2021 |
A combination of laser-assisted ALA-PDT for squamous cell carcinoma in situ and field-directed ALA-PDT for actinic keratosis.
Topics: Aminolevulinic Acid; Carcinoma, Squamous Cell; Humans; Keratosis, Actinic; Lasers; Photochemotherapy | 2022 |
Nimotuzumab shows an additive effect to inhibit cell growth of ALA-PDT treated oral cancer cells.
Topics: Aminolevulinic Acid; Antibodies, Monoclonal, Humanized; Apoptosis; Carcinoma, Squamous Cell; Cell Li | 2022 |
Therapeutic effects of topical photodynamic therapy with 5-aminolevulinic acid on cervical high-grade squamous intraepithelial lesions.
Topics: Adolescent; Adult; Aminolevulinic Acid; Carcinoma, Squamous Cell; Female; Humans; Middle Aged; Papil | 2022 |
Molecular characterization of gene expression changes in murine cutaneous squamous cell carcinoma after 5-aminolevulinic acid photodynamic therapy.
Topics: Aminolevulinic Acid; Animals; Carcinoma, Squamous Cell; Cell Line, Tumor; Gene Expression; Mice; Pho | 2022 |
Effectiveness of photodynamic therapy with 5-aminolevulinic acid for Bowenoid papulosis: A retrospective study with long-term follow-up.
Topics: Adolescent; Aminolevulinic Acid; Carcinoma, Squamous Cell; Condylomata Acuminata; Follow-Up Studies; | 2022 |
A comparison of invasive squamous cell carcinoma greater than 1 year after treatment with 5-fluorouracil, imiquimod, or photodynamic therapy with aminolevulinic acid.
Topics: Aminolevulinic Acid; Carcinoma, Squamous Cell; Fluorouracil; Humans; Imiquimod; Keratosis, Actinic; | 2022 |
In vitro 5-Fluorouracil resistance produces enhanced photodynamic therapy damage in SCC and tumor resistance in BCC.
Topics: Aminolevulinic Acid; Animals; Carcinoma, Basal Cell; Carcinoma, Squamous Cell; Fluorouracil; Humans; | 2022 |
Acitretin enhances the cytotoxic effect of 5-aminolevulinic acid photodynamic therapy on squamous cell carcinoma cells.
Topics: Acitretin; Aminolevulinic Acid; Antineoplastic Agents; Apoptosis; Carcinoma, Squamous Cell; Cell Lin | 2022 |
Identification and pharmacological modification of resistance mechanisms to protoporphyrin-mediated photodynamic therapy in human cutaneous squamous cell carcinoma cell lines.
Topics: Aminolevulinic Acid; ATP-Binding Cassette Transporters; Carcinoma, Squamous Cell; Cell Line, Tumor; | 2022 |
Vulvar lichen sclerosus progressing to squamous cell carcinoma due to the poor compliance for the follow-up after ALA-PDT.
Topics: Aminolevulinic Acid; Carcinoma, Squamous Cell; Female; Humans; Photochemotherapy; Vulvar Lichen Scle | 2022 |
Long-term follow up of ALA 10% gel and red-light photodynamic therapy for the treatment of squamous cell carcinoma in situ.
Topics: Aminolevulinic Acid; Carcinoma, Squamous Cell; Follow-Up Studies; Humans; Neoplasm Recurrence, Local | 2023 |
Long-term follow up of ALA 10% gel and red-light photodynamic therapy for the treatment of squamous cell carcinoma in situ.
Topics: Aminolevulinic Acid; Carcinoma, Squamous Cell; Follow-Up Studies; Humans; Neoplasm Recurrence, Local | 2023 |
Long-term follow up of ALA 10% gel and red-light photodynamic therapy for the treatment of squamous cell carcinoma in situ.
Topics: Aminolevulinic Acid; Carcinoma, Squamous Cell; Follow-Up Studies; Humans; Neoplasm Recurrence, Local | 2023 |
Long-term follow up of ALA 10% gel and red-light photodynamic therapy for the treatment of squamous cell carcinoma in situ.
Topics: Aminolevulinic Acid; Carcinoma, Squamous Cell; Follow-Up Studies; Humans; Neoplasm Recurrence, Local | 2023 |
Microneedle-assisted transdermal delivery of perfluorotripropylamine-based oxygenated emulsion gel loaded with 5-aminolevulinic acid for enhanced photodynamic therapy of cutaneous squamous cell carcinoma.
Topics: Aminolevulinic Acid; Animals; Carcinoma, Squamous Cell; Emulsions; Humans; Mice; Oxygen; Photochemot | 2023 |
Evaluating the safety and efficacy of aminolevulinic acid 20% topical solution activated by pulsed dye laser and blue light in the treatment of facial cutaneous squamous cell carcinoma in situ.
Topics: Adult; Aminolevulinic Acid; Carcinoma, Squamous Cell; Cohort Studies; Humans; Lasers, Dye; Photochem | 2023 |
Modified 5-aminolevulinic acid photodynamic therapy induces cutaneous squamous cell carcinoma cell pyroptosis via the JNK signaling pathway.
Topics: Aminolevulinic Acid; Carcinoma, Squamous Cell; Humans; Inflammasomes; MAP Kinase Signaling System; N | 2024 |
Photodynamic therapy enhances skin cancer chemotherapy effects through autophagy regulation.
Topics: Adenine; Aminolevulinic Acid; Autophagy; Carcinoma, Squamous Cell; Cell Line, Tumor; Cell Proliferat | 2019 |
An audit of pain scores with conventional and white light topical 5-methyl aminolaevulinic acid photodynamic therapy for superficial basal cell carcinoma and squamous cell carcinoma in situ.
Topics: Aged; Aged, 80 and over; Aminolevulinic Acid; Carcinoma, Basal Cell; Carcinoma, Squamous Cell; Femal | 2020 |
Photodynamic therapy for cutaneous squamous cell carcinoma in situ: Impact of anatomic location, tumor diameter, and incubation time on effectiveness.
Topics: Aged; Aged, 80 and over; Aminolevulinic Acid; Analysis of Variance; Biopsy, Needle; Carcinoma in Sit | 2020 |
Photodynamic therapy for squamous cell carcinoma of the index finger: A case report.
Topics: Aged; Aminolevulinic Acid; Carcinoma, Squamous Cell; Fingers; Humans; Male; Photochemotherapy; Photo | 2020 |
Photodynamic therapy in combination with surgery for the treatment of an extensive squamous cell carcinoma in situ - A case report.
Topics: Aminolevulinic Acid; Bowen's Disease; Carcinoma, Basal Cell; Carcinoma, Squamous Cell; Humans; Neopl | 2020 |
Efficacy and safety of 5-aminolevulinic acid photodynamic therapy for the treatment of ulcerative squamous cell carcinoma.
Topics: Aminolevulinic Acid; Carcinoma, Squamous Cell; Humans; Neoplasm Recurrence, Local; Photochemotherapy | 2020 |
Exosomes from 5-aminolevulinic acid photodynamic therapy-treated squamous carcinoma cells promote dendritic cell maturation.
Topics: Aminolevulinic Acid; Carcinoma, Squamous Cell; Dendritic Cells; Exosomes; Humans; Photochemotherapy; | 2020 |
Clinical evaluation of smartphone-based fluorescence imaging for guidance and monitoring of ALA-PDT treatment of early oral cancer.
Topics: Aminolevulinic Acid; Carcinoma, Squamous Cell; Humans; Mouth Neoplasms; Optical Imaging; Photochemot | 2020 |
Epigallocatechin Gallate Enhances MAL-PDT Cytotoxic Effect on PDT-Resistant Skin Cancer Squamous Cells.
Topics: Aminolevulinic Acid; Anticarcinogenic Agents; Carcinoma, Squamous Cell; Catechin; Cell Death; Cell H | 2020 |
Photodynamic therapy as an alternative treatment in patients with invasive cutaneous SCC where surgery is not feasible: Single center experience.
Topics: Aminolevulinic Acid; Carcinoma, Squamous Cell; Humans; Neoplasm Recurrence, Local; Photochemotherapy | 2020 |
Surgery sequential with 5-Aminolevulinic acid photodynamic therapy for lip squamous cell carcinoma: Two cases reports.
Topics: Aminolevulinic Acid; Carcinoma, Squamous Cell; Head and Neck Neoplasms; Humans; Lip; Photochemothera | 2020 |
5-aminolevulinic acid photodynamic therapy inhibits invasion and metastasis of SCL-1 cells probably via MTSS1 and p63 gene related pathways.
Topics: Aminolevulinic Acid; Carcinoma, Squamous Cell; Cell Line, Tumor; Humans; Membrane Proteins; Microfil | 2020 |
Painless Photodynamic Therapy Triggers Innate and Adaptive Immune Responses in a Murine Model of UV-induced Squamous Skin Pre-cancer.
Topics: Aminolevulinic Acid; Animals; Carcinoma, Squamous Cell; Disease Models, Animal; Immunity; Keratosis, | 2021 |
Ingenol Mebutate and the Treatment of Actinic Keratosis.
Topics: Aminolevulinic Acid; Carcinoma, Squamous Cell; Clinical Trials as Topic; Diterpenes; Fluorouracil; H | 2021 |
Co-delivery of chitosan nanoparticles of 5-aminolevulinic acid and shGBAS for improving photodynamic therapy efficacy in oral squamous cell carcinomas.
Topics: Aminolevulinic Acid; Animals; Carcinoma, Squamous Cell; Cell Line, Tumor; Chitosan; Head and Neck Ne | 2021 |
5-Aminolevulinic acid photodynamic therapy for early-stage lip squamous cell carcinoma.
Topics: Aminolevulinic Acid; Carcinoma, Squamous Cell; China; Head and Neck Neoplasms; Humans; Lip; Neoplasm | 2021 |
Photodynamic therapy utilizing 10% ALA nano-emulsion gel and red-light for the treatment of squamous cell carcinoma in-situ on the trunk and extremities: Pilot study and literature update.
Topics: Aminolevulinic Acid; Carcinoma, Squamous Cell; Extremities; Humans; Photochemotherapy; Photosensitiz | 2021 |
ALA-PDT successfully treated multiple cSCC in situ and AK in a patient with Epidermodysplasia verruciformis.
Topics: Aminolevulinic Acid; Carcinoma, Squamous Cell; Epidermodysplasia Verruciformis; Humans; Keratosis, A | 2021 |
Novel strategy in giant cutaneous squamous cell carcinoma treatment: The case experience with a combination of photodynamic therapy and surgery.
Topics: Aged, 80 and over; Aminolevulinic Acid; Carcinoma, Squamous Cell; Humans; Male; Photochemotherapy; P | 2017 |
Development of squamous cell carcinoma from erythroplasia of Queyrat following photodynamic therapy.
Topics: Aged; Aminolevulinic Acid; Carcinoma, Squamous Cell; Disease Progression; Erythroplasia; Humans; Mal | 2018 |
Antitumor Effects of DC Vaccine With ALA-PDT-Induced Immunogenic Apoptotic Cells for Skin Squamous Cell Carcinoma in Mice.
Topics: Administration, Topical; Aminolevulinic Acid; Animals; Antigen-Presenting Cells; Cancer Vaccines; Ca | 2018 |
Therapeutic effect of Imiquimod enhanced ALA-PDT on cutaneous squamous cell carcinoma.
Topics: Aged; Aminolevulinic Acid; Animals; Apoptosis; Carcinoma, Squamous Cell; Disease Models, Animal; Dru | 2018 |
Thermal photodynamic therapy increases apoptosis and reactive oxygen species generation in cutaneous and mucosal squamous cell carcinoma cells.
Topics: Aminolevulinic Acid; Apoptosis; Carcinoma, Squamous Cell; Cell Line, Tumor; Hot Temperature; Humans; | 2018 |
Development and evaluation of a low-cost, portable, LED-based device for PDT treatment of early-stage oral cancer in resource-limited settings.
Topics: Aminolevulinic Acid; Animals; Antineoplastic Agents; Carcinoma, Squamous Cell; Cell Line, Tumor; Dev | 2019 |
Photodynamic Therapy Mediated by 5-aminolevulinic Acid Promotes the Upregulation and Modifies the Intracellular Expression of Surveillance Proteins in Oral Squamous Cell Carcinoma.
Topics: Aminolevulinic Acid; Carcinoma, Squamous Cell; Humans; Mouth Neoplasms; Photochemotherapy; Photosens | 2019 |
Photodynamic therapy on skin melanoma and epidermoid carcinoma cells using conjugated 5-aminolevulinic acid with microbial synthesised silver nanoparticles.
Topics: Aminolevulinic Acid; Animals; Bacillus licheniformis; Carcinoma, Squamous Cell; Cell Line, Tumor; Hu | 2019 |
Photodynamic therapy with a 5-ALA patch does not increase the risk of conversion of actinic keratoses into squamous cell carcinoma: Results of a multicentre non-interventional study.
Topics: Aminolevulinic Acid; Carcinoma, Squamous Cell; Disease Progression; DNA Damage; Humans; Keratosis, A | 2018 |
Hyperbaric Oxygen Combined with 5-Aminolevulinic Acid Photodynamic Therapy Inhibited Human Squamous Cell Proliferation.
Topics: Aminolevulinic Acid; bcl-2-Associated X Protein; Carcinoma, Squamous Cell; Caspase 3; Cell Line, Tum | 2019 |
CCL8 enhances sensitivity of cutaneous squamous cell carcinoma to photodynamic therapy by recruiting M1 macrophages.
Topics: Aminolevulinic Acid; Animals; Carcinoma, Squamous Cell; Cell Line, Tumor; Cell Movement; Chemokine C | 2019 |
lncRNA TINCR participates in ALA-PDT-induced apoptosis and autophagy in cutaneous squamous cell carcinoma.
Topics: Aminolevulinic Acid; Apoptosis; Autophagy; Base Sequence; Carcinoma, Squamous Cell; Cell Line, Tumor | 2019 |
The effect of C-X-C motif chemokine ligand 13 in cutaneous squamous cell carcinoma treated with aminolevulinic acid-photodynamic therapy.
Topics: Aged; Aged, 80 and over; Aminolevulinic Acid; Animals; Carcinoma, Squamous Cell; Chemokine CXCL13; F | 2019 |
Methadone enhances the effectiveness of 5-aminolevulinic acid-based photodynamic therapy for squamous cell carcinoma and glioblastoma in vitro.
Topics: Aminolevulinic Acid; Apoptosis; Carcinoma, Squamous Cell; Cell Cycle; Cell Line, Tumor; Drug Synergi | 2019 |
The effect of ALA-PDT on reversing the activation of cancer-associated fibroblasts in cutaneous squamous cell carcinoma.
Topics: Actins; Aminolevulinic Acid; Animals; Cancer-Associated Fibroblasts; Carcinoma, Squamous Cell; Cell | 2019 |
The role of reflectance confocal microscopy in the diagnosis and management of squamous cell carcinoma in situ treated with photodynamic therapy.
Topics: Aftercare; Aged; Aged, 80 and over; Aminolevulinic Acid; Biopsy; Carcinoma, Squamous Cell; Epidermis | 2019 |
Therapeutic and immune effects of 5-aminolevulinic acid photodynamic therapy on UVB-induced squamous cell carcinomas in hairless mice.
Topics: Aminolevulinic Acid; Animals; Carcinoma, Squamous Cell; Mice; Mice, Hairless; Neoplasms, Radiation-I | 2013 |
Laser photodynamic treatment for in situ squamous cell carcinoma of the glans monitored by reflectance confocal microscopy.
Topics: Aged; Aminolevulinic Acid; Carcinoma in Situ; Carcinoma, Squamous Cell; Humans; Laser Therapy; Male; | 2014 |
Improvement of the efficacy of 5-aminolevulinic acid-mediated photodynamic treatment in human oral squamous cell carcinoma HSC-4.
Topics: Amino Acid Chloromethyl Ketones; Aminolevulinic Acid; Apoptosis; ATP Binding Cassette Transporter, S | 2013 |
Cisplatin enhances the efficacy of 5-aminolevulinic acid mediated photodynamic therapy in human head and neck squamous cell carcinoma.
Topics: Aminolevulinic Acid; Animals; Antineoplastic Agents; Carcinoma, Squamous Cell; Cell Line, Tumor; Cel | 2014 |
Artificial daylight photodynamic therapy with "non-inflammatory" doses of hexyl aminolevulinate only marginally delays SCC development in UV-exposed hairless mice.
Topics: Aminolevulinic Acid; Animals; Carcinoma, Squamous Cell; Female; Mice; Mice, Hairless; Photochemother | 2013 |
Efficacy of photodynamic diagnosis-guided Mohs micrographic surgery in primary squamous cell carcinoma.
Topics: Adult; Aged; Aged, 80 and over; Aminolevulinic Acid; Biopsy; Carcinoma, Squamous Cell; Facial Neopla | 2013 |
Photodynamic diagnosis of metastatic lymph nodes using 5-aminolevulinic acid in mouse squamous cell carcinoma.
Topics: Aminolevulinic Acid; Animals; Carcinoma, Squamous Cell; Feasibility Studies; Fluorescence; Lymph Nod | 2014 |
Methotrexate enhances 5-aminolevulinic acid-mediated photodynamic therapy-induced killing of human SCC4 cells by upregulation of coproporphyrinogen oxidase.
Topics: Aminolevulinic Acid; Carcinoma, Squamous Cell; Coproporphyrinogen Oxidase; Humans; Methotrexate; Mou | 2014 |
Design and validation of a fiber optic point probe instrument for therapy guidance and monitoring.
Topics: Aminolevulinic Acid; Animals; Calibration; Carcinoma, Squamous Cell; Equipment Design; Fiber Optic T | 2014 |
Development of squamous cell carcinoma after photodynamic therapy with methyl aminoleuvulinate.
Topics: Aged; Aged, 80 and over; Aminolevulinic Acid; Carcinoma, Squamous Cell; Female; Head and Neck Neopla | 2014 |
Methyl-aminolevulinic acid photodynamic therapy for actinic keratoses: a useful treatment or a risk factor? A retrospective study.
Topics: Aged; Aged, 80 and over; Aminolevulinic Acid; Carcinoma, Squamous Cell; Female; Follow-Up Studies; H | 2015 |
Rapid development of squamous cell carcinoma after photodynamic therapy.
Topics: Aged; Aminolevulinic Acid; Bowen's Disease; Carcinoma, Squamous Cell; Disease Progression; Facial Ne | 2014 |
Combination therapy for perianal squamous cell carcinoma in situ with imiquimod and photodynamic therapy.
Topics: Aminolevulinic Acid; Aminoquinolines; Anal Canal; Antineoplastic Agents; Carcinoma, Squamous Cell; C | 2014 |
Treating cutaneous squamous cell carcinoma using 5-aminolevulinic acid polylactic-co-glycolic acid nanoparticle-mediated photodynamic therapy in a mouse model.
Topics: Aminolevulinic Acid; Animals; Carcinoma, Squamous Cell; Lactic Acid; Mice; Mice, Hairless; Nanoparti | 2015 |
Improvement of DC vaccine with ALA-PDT induced immunogenic apoptotic cells for skin squamous cell carcinoma.
Topics: Aminolevulinic Acid; Animals; Apoptosis; Cancer Vaccines; Carcinoma, Squamous Cell; Dendritic Cells; | 2015 |
Photodynamic therapy for nonmelanoma skin cancer of the genital area: our experience.
Topics: Adult; Aged; Aminolevulinic Acid; Bowen's Disease; Carcinoma, Squamous Cell; Female; Follow-Up Studi | 2015 |
Actinic keratosis: a cross-sectional study of disease characteristics and treatment patterns in Danish dermatology clinics.
Topics: Adult; Age Factors; Aged; Aged, 80 and over; Aminolevulinic Acid; Aminoquinolines; Antineoplastic Ag | 2016 |
A photodynamic therapy combined with topical 5-aminolevulinic acid and systemic hematoporphyrin derivative is more efficient but less phototoxic for cancer.
Topics: Adult; Aged; Aminolevulinic Acid; Antineoplastic Agents; Carcinoma, Basal Cell; Carcinoma, Squamous | 2016 |
Photodynamic therapy activated STAT3 associated pathways: Targeting intrinsic apoptotic pathways to increase PDT efficacy in human squamous carcinoma cells.
Topics: Aminolevulinic Acid; Apoptosis; Carcinoma, Squamous Cell; Cell Line, Tumor; Drug Delivery Systems; F | 2016 |
Stimulation of dendritic cells by DAMPs in ALA-PDT treated SCC tumor cells.
Topics: Aminolevulinic Acid; Animals; Calreticulin; Cancer Vaccines; Carcinoma, Squamous Cell; Cytokines; De | 2015 |
Skin tumor development after UV irradiation and photodynamic therapy is unaffected by short-term pretreatment with 5-fluorouracil, imiquimod and calcipotriol. An experimental hairless mouse study.
Topics: Aminolevulinic Acid; Aminoquinolines; Animals; Calcitriol; Carcinoma, Squamous Cell; Female; Fluorou | 2016 |
Using Fourier transform infrared spectroscopy to evaluate biological effects induced by photodynamic therapy.
Topics: Aminolevulinic Acid; Animals; Biomarkers, Tumor; Carcinoma, Squamous Cell; Discriminant Analysis; Fe | 2016 |
Potency of different red light sources in photodynamic induction of cell death in a squamous cell carcinoma cell line.
Topics: Aminolevulinic Acid; Carcinoma, Squamous Cell; Cell Line, Tumor; Color; Dose-Response Relationship, | 2016 |
Inhibition of MAPK signaling pathways enhances cell death induced by 5-Aminolevulinic acid-photodynamic therapy in skin squamous carcinoma cells.
Topics: Aminolevulinic Acid; Annexin A5; Apoptosis; Carcinoma, Squamous Cell; Cell Line, Tumor; Cell Surviva | 2016 |
Surgery combined with topical photodynamic therapy for the treatment of squamous cell carcinoma of the lip.
Topics: Adult; Aminolevulinic Acid; Carcinoma, Squamous Cell; Follow-Up Studies; Humans; Lip; Male; Photoche | 2016 |
Dermoscopy and methyl aminolevulinate: A study for detection and evaluation of field cancerization.
Topics: Aged; Aminolevulinic Acid; Carcinoma, Squamous Cell; Dermoscopy; Humans; Keratosis, Actinic; Middle | 2016 |
Ingenol Mebutate vs. Daylight Photodynamic Therapy in a Kidney Transplant Recipient.
Topics: Aged; Aminolevulinic Acid; Antineoplastic Agents; Carcinogenesis; Carcinoma, Basal Cell; Carcinoma, | 2016 |
Comparing desferrioxamine and light fractionation enhancement of ALA-PpIX photodynamic therapy in skin cancer.
Topics: Aminolevulinic Acid; Animals; Carcinoma, Squamous Cell; Cell Line, Tumor; Deferoxamine; Dose Fractio | 2016 |
Optimization and therapeutic effects of PDT mediated by ALA and MAL in the treatment of cutaneous malignant lesions: A comparative study.
Topics: Aminolevulinic Acid; Animals; Carcinoma, Squamous Cell; Female; Mice; Photochemotherapy; Photosensit | 2016 |
Effect of (R)L-sulforaphane on 5-aminolevulinic acid-mediated photodynamic therapy.
Topics: Aminolevulinic Acid; Anticarcinogenic Agents; Carcinoma, Squamous Cell; Cell Line, Tumor; Drug Scree | 2008 |
Etretinate enhances the susceptibility of human skin squamous cell carcinoma cells to 5-aminolaevulic acid-based photodynamic therapy.
Topics: Aminolevulinic Acid; Apoptosis; Carcinoma, Squamous Cell; Cell Death; Dose-Response Relationship, Dr | 2009 |
Photodynamic therapy for the treatment of in situ squamous cell carcinoma of the left eyelid.
Topics: Aminolevulinic Acid; Carcinoma in Situ; Carcinoma, Squamous Cell; Eyelid Neoplasms; Humans; Male; Mi | 2008 |
Treatment of skin cancer and pre-cancer using topical ALA-PDT--a single hospital experience.
Topics: Administration, Topical; Adult; Aged; Aminolevulinic Acid; Carcinoma, Basal Cell; Carcinoma, Squamou | 2008 |
[Fluorescence analysis of oral squamous cell carcinoma with 5-aminolevulinic acid labeling].
Topics: Aminolevulinic Acid; Animals; Carcinoma, Squamous Cell; Fluorescence; Humans; Mice; Mice, SCID; Mout | 2009 |
Calcitriol treatment improves methyl aminolaevulinate-based photodynamic therapy in human squamous cell carcinoma A431 cells.
Topics: Aminolevulinic Acid; Calcitriol; Carcinoma, Basal Cell; Carcinoma, Squamous Cell; Cell Line, Tumor; | 2009 |
Photodynamic therapy with 5-aminolevulinic acid and diamino acid derivatives of protoporphyrin IX reduces papillomas in mice without eliminating transformation into squamous cell carcinoma of the skin.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Aminolevulinic Acid; Animals; Carcinogens; Carcinoma, Squamous Cel | 2009 |
Methyl-aminolevulinate photodynamic therapy for the treatment of actinic keratoses and non-melanoma skin cancers: a retrospective analysis of response in 462 patients.
Topics: Aged; Aged, 80 and over; Aminolevulinic Acid; Bowen's Disease; Carcinoma, Basal Cell; Carcinoma, Squ | 2009 |
The clinical efficacy of topical methyl-aminolevulinate photodynamic therapy in moderate to severe actinic keratoses of the face and scalp.
Topics: Administration, Topical; Aged; Aged, 80 and over; Aminolevulinic Acid; Analysis of Variance; Carcino | 2010 |
Anticancer effect of photodynamic therapy with hexenyl ester of 5-aminolevulinic acid in oral squamous cell carcinoma.
Topics: Aminolevulinic Acid; Blotting, Western; Carcinoma, Squamous Cell; Caspase 3; Cell Death; Cell Surviv | 2010 |
Photodynamic therapy with topical methyl- and hexylaminolevulinate for prophylaxis and treatment of UV-induced SCC in hairless mice.
Topics: Administration, Topical; Aminolevulinic Acid; Animals; Carcinoma, Squamous Cell; Disease Models, Ani | 2010 |
[Fluorescence diagnostics of skin tumors using 5-aminolevulinic acid and its methyl ester].
Topics: Adult; Aged; Aged, 80 and over; Aminolevulinic Acid; Carcinoma, Basal Cell; Carcinoma, Squamous Cell | 2009 |
In vivo temporal evolution of ALA-induced normalized fluorescence at different anatomical locations of oral cavity: application to improve cancer diagnostic contrast and potential.
Topics: Administration, Topical; Aminolevulinic Acid; Carcinoma, Squamous Cell; Diagnosis, Oral; Humans; Mou | 2010 |
The efficacy of photodynamic diagnosis in defining the lateral border between a tumor and a tumor-free area during Mohs micrographic surgery.
Topics: Administration, Topical; Adult; Aged; Aged, 80 and over; Aminolevulinic Acid; Bowen's Disease; Carci | 2010 |
Pre-surgical mapping of cutaneous non-melanoma carcinoma using topical methyl aminolevulinic acid.
Topics: Administration, Cutaneous; Aminolevulinic Acid; Carcinoma; Carcinoma, Basal Cell; Carcinoma, Squamou | 2011 |
Clearance of a thick invasive squamous cell carcinoma after multiple treatments with topical photodynamic therapy.
Topics: Administration, Topical; Aminolevulinic Acid; Biopsy, Needle; Carcinoma, Squamous Cell; Female; Foll | 2010 |
Fluorescence diagnosis in actinic keratosis and squamous cell carcinoma.
Topics: Aged; Aged, 80 and over; Aminolevulinic Acid; Carcinoma, Squamous Cell; Diagnosis, Differential; Fem | 2010 |
Complete resolution of a squamous cell carcinoma of the skin using intralesional 5-aminolevulinic acid photodynamic therapy intralesional PDT for SCC.
Topics: Aged, 80 and over; Aminolevulinic Acid; Carcinoma, Squamous Cell; Female; Humans; Injections, Intral | 2010 |
Apoptosis of SAS cells induced by sonodynamic therapy using 5-aminolevulinic acid sonosensitizer.
Topics: Aminolevulinic Acid; Apoptosis; Carcinoma, Squamous Cell; Combined Modality Therapy; Flow Cytometry; | 2011 |
Photodynamic diagnosis of tumor margins using methyl aminolevulinate before Mohs micrographic surgery.
Topics: Aged; Aged, 80 and over; Aminolevulinic Acid; Carcinoma, Basal Cell; Carcinoma, Squamous Cell; Femal | 2011 |
Isolation and characterization of squamous carcinoma cells resistant to photodynamic therapy.
Topics: Aminolevulinic Acid; beta Catenin; Cadherins; Carcinoma, Squamous Cell; Cell Adhesion Molecules; Cel | 2011 |
Vitamin D3 enhances the apoptotic response of epithelial tumors to aminolevulinate-based photodynamic therapy.
Topics: Aminolevulinic Acid; Animals; Calcitriol; Carcinoma, Squamous Cell; Caspase 3; Caspase 8; Cell Diffe | 2011 |
Methyl-aminolevulinate photodynamic therapy for the treatment of erythroplasia of Queyrat in 23 patients.
Topics: Adult; Aged; Aged, 80 and over; Aminolevulinic Acid; Carcinoma, Squamous Cell; Erythroplasia; Humans | 2012 |
Intraoperative photodynamic therapy: a description of a new adjuvant technique for patients with nonmelanoma skin cancer.
Topics: Aminolevulinic Acid; Carcinoma, Basal Cell; Carcinoma, Squamous Cell; Color; Combined Modality Thera | 2012 |
Low-intensity ultrasound combined with 5-aminolevulinic acid administration in the treatment of human tongue squamous carcinoma.
Topics: Aminolevulinic Acid; Animals; Apoptosis; bcl-2-Associated X Protein; Calcium; Carcinoma, Squamous Ce | 2012 |
The interpretation of clinical studies on the photodynamic treatment of actinic keratosis.
Topics: Aminolevulinic Acid; Carcinoma, Squamous Cell; Clinical Trials as Topic; Humans; Keratosis, Actinic; | 2012 |
Evaluation of photodynamic therapy of skin cancers with partial differential alpha-aminolevulinic acid.
Topics: Adult; Aged; Aminolevulinic Acid; Carcinoma, Basal Cell; Carcinoma, Squamous Cell; Female; Follow-Up | 2002 |
Detection of squamous cell carcinomas and pre-cancerous lesions in the oral cavity by quantification of 5-aminolevulinic acid induced fluorescence endoscopic images.
Topics: Adult; Aged; Aged, 80 and over; Algorithms; Aminolevulinic Acid; Carcinoma, Squamous Cell; Diagnosti | 2002 |
Autofluorescence and 5-aminolevulinic acid induced fluorescence diagnosis of penile carcinoma -- new techniques to monitor Nd:YAG laser therapy.
Topics: Aged; Aminolevulinic Acid; Carcinoma, Squamous Cell; Diagnostic Techniques, Surgical; Fluorescence; | 2002 |
Gene expression pattern following photodynamic treatment of the carcinoma cell line A-431 analysed by cDNA arrays.
Topics: Aminolevulinic Acid; Apoptosis; Carcinoma, Squamous Cell; Cell Survival; Enzyme Induction; Gene Expr | 2002 |
[Fluorescence staining of oral and laryngeal cancer after application of 5-aminolevulinic acid].
Topics: Administration, Inhalation; Administration, Oral; Aminolevulinic Acid; Biopsy; Carcinoma, Squamous C | 2002 |
Detection and diagnosis of oral cancer by light-induced fluorescence.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Aminolevulinic Acid; Animals; Carcinogens; Carcinoma, Squamous Cel | 2003 |
Acceleration of ALA-induced PpIX fluorescence development in the oral mucosa.
Topics: Administration, Topical; Aminolevulinic Acid; Analysis of Variance; Animals; Carcinoma, Squamous Cel | 2003 |
Hypericin activated by an incoherent light source has photodynamic effects on esophageal cancer cells.
Topics: Adenocarcinoma; Aminolevulinic Acid; Anthracenes; Antineoplastic Agents; Apoptosis; Carcinoma, Squam | 2003 |
Cyclooxygenase-2 is a possible target of treatment approach in conjunction with photodynamic therapy for various disorders in skin and oral cavity.
Topics: Aminolevulinic Acid; Bowen's Disease; Carcinoma, Squamous Cell; Cell Division; Cell Line, Tumor; Cyc | 2004 |
Squamous cell carcinoma of the eyelid treated with photodynamic therapy.
Topics: Aminolevulinic Acid; Biopsy, Needle; Carcinoma, Squamous Cell; Eyelid Neoplasms; Follow-Up Studies; | 2004 |
Enhancement of photodynamic therapy by use of aminolevulinic acid/glycolic acid drug mixture.
Topics: Adenocarcinoma; Administration, Cutaneous; Aged; Aminolevulinic Acid; Animals; Antineoplastic Combin | 2004 |
Erythroplasia of Queyrat treated with topical methyl aminolevulinate photodynamic therapy.
Topics: Administration, Topical; Aged; Aged, 80 and over; Aminolevulinic Acid; Carcinoma, Squamous Cell; Ery | 2005 |
Induction of hypoxia-inducible factor-1alpha overexpression by cobalt chloride enhances cellular resistance to photodynamic therapy.
Topics: Aminolevulinic Acid; Carcinoma, Squamous Cell; Cell Differentiation; Cell Survival; Cells, Cultured; | 2006 |
PDT as a cytotoxic agent and biological response modifier: Implications for cancer prevention and treatment in immunosuppressed and immunocompetent patients.
Topics: Aminolevulinic Acid; Carcinoma, Squamous Cell; Humans; Immunocompetence; Immunologic Factors; Immuno | 2006 |
Subcellular localization pattern of protoporphyrin IX is an important determinant for its photodynamic efficiency of human carcinoma and normal cell lines.
Topics: Adenosine Triphosphate; Aminolevulinic Acid; Carcinoma, Squamous Cell; Cell Line; Cell Line, Tumor; | 2006 |
Influence of administration methods on the accumulation of ALA-induced Pp-IX in mouse tongue tumors.
Topics: Administration, Oral; Administration, Topical; Aminolevulinic Acid; Animals; Carcinoma, Squamous Cel | 2006 |
Long-Segment early squamous cell carcinoma of the proximal esophagus: curative treatment and long-term follow-up after 5-aminolevulinic acid (5-ALA)-photodynamic therapy.
Topics: Aminolevulinic Acid; Biopsy; Carcinoma, Squamous Cell; Disease-Free Survival; Endoscopy, Gastrointes | 2006 |
Chemopreventative thoughts for photodynamic therapy.
Topics: Aminolevulinic Acid; Animals; Carcinoma, Squamous Cell; Humans; Keratosis; Mice; Neoplasms, Radiatio | 2007 |
Pharmacokinetics of the photosensitizers aminolevulinic acid and aminolevulinic acid hexylester in oro-facial tumors embedded in the chorioallantois membrane of a hen's egg.
Topics: Adult; Aged; Aged, 80 and over; Aminolevulinic Acid; Animals; Biopsy; Carcinoma, Squamous Cell; Chic | 2006 |
Macromolecular delivery of 5-aminolaevulinic acid for photodynamic therapy using dendrimer conjugates.
Topics: Aminolevulinic Acid; Animals; Carcinoma, Squamous Cell; Cell Survival; Cells, Cultured; Dendrimers; | 2007 |
Fluorescence diagnosis in keratinocytic intraepidermal neoplasias.
Topics: Adult; Aged; Aged, 80 and over; Aminolevulinic Acid; Carcinoma, Squamous Cell; Cell Proliferation; D | 2007 |
Biochemical manipulation via iron chelation to enhance porphyrin production from porphyrin precursors.
Topics: Aminolevulinic Acid; Carcinoma, Squamous Cell; Cell Line, Tumor; Deferoxamine; Dose-Response Relatio | 2007 |
Detection of mucosal abnormalities in patients with oral cancer using a photodynamic technique: A pilot study.
Topics: Aged; Aged, 80 and over; Aminolevulinic Acid; Carcinoma, Squamous Cell; Female; Humans; Male; Middle | 2008 |
Thioredoxin upregulation by 5-aminolaevulinic acid-based photodynamic therapy in human skin squamous cell carcinoma cell line.
Topics: Aminolevulinic Acid; Analysis of Variance; Blotting, Western; Carcinoma, Squamous Cell; Caspase 3; C | 2008 |
Methylaminolaevulinate-based photodynamic therapy of Bowen's disease and squamous cell carcinoma.
Topics: Aged; Aged, 80 and over; Aminolevulinic Acid; Bowen's Disease; Carcinoma, Squamous Cell; Dose-Respon | 2008 |
[The synergistic effect of delta-aminolevulinic acid and photodynamic laser therapy based on an in vitro model of the ATP tumor chemosensitivity test].
Topics: Adenosine Triphosphate; Aminolevulinic Acid; Carcinoma, Squamous Cell; Cell Line; Cell Survival; Dos | 1995 |
Experimental photodynamic therapy of the larynx using 5-aminolaevulinic acid.
Topics: Aminolevulinic Acid; Animals; Carcinoma, Squamous Cell; Dose-Response Relationship, Drug; Injections | 1995 |
Photodynamic therapy of superficial skin tumors following local application of delta-aminolaevulinic acid.
Topics: Aminolevulinic Acid; Carcinoma, Squamous Cell; Fluorescence; Humans; Lip; Lip Neoplasms; Photochemot | 1995 |
Photodynamic therapy of oral cancer: photosensitisation with systemic aminolaevulinic acid.
Topics: Administration, Oral; Aminolevulinic Acid; Carcinoma, Squamous Cell; Fluorescence; Humans; Laser The | 1993 |
Photodynamic therapy of nonmelanoma skin cancer with topical aminolevulinic acid: a clinical and histologic study.
Topics: Administration, Cutaneous; Aged; Aminolevulinic Acid; Carcinoma in Situ; Carcinoma, Basal Cell; Carc | 1995 |
Endogenous porphyrins in murine skin and transplanted PAM-212 squamous cell carcinoma tissues after injection of delta-aminolevulinic acid.
Topics: Aminolevulinic Acid; Animals; Carcinoma, Squamous Cell; Coproporphyrins; Female; Mice; Mice, Inbred | 1995 |
A mechanistic study of cellular photodestruction with 5-aminolaevulinic acid-induced porphyrin.
Topics: Aminolevulinic Acid; Animals; Carcinoma, Squamous Cell; Carcinoma, Transitional Cell; Cell Division; | 1994 |
Topical photodynamic therapy with endogenous porphyrins after application of 5-aminolevulinic acid. An alternative treatment modality for solar keratoses, superficial squamous cell carcinomas, and basal cell carcinomas?
Topics: Administration, Cutaneous; Adult; Aged; Aged, 80 and over; Aminolevulinic Acid; Carcinoma, Basal Cel | 1993 |
Lethal photosensitization by endogenous porphyrins of PAM cells--modification by desferrioxamine.
Topics: Aminolevulinic Acid; Animals; Carcinoma, Squamous Cell; Cell Division; Cell Survival; Darkness; Defe | 1993 |
Influence of activation and differentiation of cells on the effectiveness of photodynamic therapy.
Topics: Aminolevulinic Acid; Carcinoma, Squamous Cell; Cell Differentiation; Cell Division; Cell Line, Trans | 1995 |
Kinetics and localisation of PpIX fluorescence after topical and systemic ALA application, observed in skin and skin tumours of UVB-treated mice.
Topics: Administration, Topical; Aminolevulinic Acid; Animals; Carcinoma, Squamous Cell; Female; Injections, | 1996 |
Photodynamic therapy using 5-aminolevulinic acid for premalignant and malignant lesions of the oral cavity.
Topics: Aged; Aged, 80 and over; Aminolevulinic Acid; Carcinoma, Squamous Cell; Female; Follow-Up Studies; H | 1996 |
[Photodynamic diagnosis of neoplasms of the mouth cavity after local administration of 5-aminolevulinic acid].
Topics: Administration, Topical; Aged; Aminolevulinic Acid; Carcinoma, Squamous Cell; Female; Fluorescence; | 1996 |
Fluorescence imaging and spectroscopy of 5-aminolevulinic acid induced protoporphyrin IX for the detection of neoplastic lesions in the oral cavity.
Topics: Administration, Topical; Aminolevulinic Acid; Carcinoma, Squamous Cell; Endoscopy; Humans; Middle Ag | 1996 |
Development of malignant melanoma after repeated topical photodynamic therapy with 5-aminolevulinic acid at the exposed site.
Topics: Aged; Aged, 80 and over; Alopecia; Aminolevulinic Acid; Carcinoma, Squamous Cell; Follow-Up Studies; | 1997 |
Photodynamic therapy of bladder cancer cell lines.
Topics: Aminolevulinic Acid; Carcinoma, Squamous Cell; Carcinoma, Transitional Cell; Cell Survival; Dose-Res | 1997 |
The kinetics of protoporphyrin fluorescence during ALA-PDT in human malignant skin tumors.
Topics: Aminolevulinic Acid; Carcinoma, Basal Cell; Carcinoma, Squamous Cell; Fluorescence; Humans; Photoche | 1997 |
[Photodynamic therapy of early squamous epithelial carcinomas and severe squamous epithelial dysplasias of the esophagus with 5-aminolevulinic acid].
Topics: Administration, Oral; Aged; Aminolevulinic Acid; Carcinoma, Squamous Cell; Esophageal Neoplasms; Eso | 1998 |
Modified topical photodynamic therapy of superficial skin tumors, utilizing aminolevulinic acid, penetration enhancers, red light, and hyperthermia.
Topics: Administration, Cutaneous; Aged; Aminolevulinic Acid; Bowen's Disease; Carcinoma, Basal Cell; Carcin | 1998 |
Systemic application of photosensitizers in the chick chorioallantoic membrane (CAM) model: photodynamic response of CAM vessels and 5-aminolevulinic acid uptake kinetics by transplantable tumors.
Topics: Allantois; Aminolevulinic Acid; Animals; Biological Transport; Carcinoma, Squamous Cell; Cell Divisi | 1999 |
A new long-range through-the-scope balloon applicator for photodynamic therapy in the esophagus and cardia.
Topics: Adenocarcinoma; Aged; Aminolevulinic Acid; Barrett Esophagus; Biopsy; Carcinoma, Squamous Cell; Card | 1999 |
Preclinical study in cats of the pro-photosensitizer 5-aminolevulinic acid.
Topics: Aminolevulinic Acid; Animals; Biotransformation; Carcinoma, Squamous Cell; Cat Diseases; Cats; Cell | 1999 |
Photodynamic therapy for esophageal lesions: selectivity depends on wavelength, power, and light dose.
Topics: Aminolevulinic Acid; Animals; Carcinoma, Squamous Cell; Esophageal Neoplasms; Esophagus; Hematoporph | 1999 |
Detection of squamous cell carcinoma of the oral cavity by imaging 5-aminolevulinic acid-induced protoporphyrin IX fluorescence.
Topics: Adult; Aged; Aminolevulinic Acid; Biopsy; Carcinoma, Squamous Cell; Humans; Middle Aged; Mouth; Mout | 2000 |
Intraoperative detection of 5-aminolaevulinic acid-induced protoporphyrin fluorescence in lymph node metastases after oral administration.
Topics: Aged; Aminolevulinic Acid; Carcinoma, Squamous Cell; Female; Fluorescence; Humans; Intraoperative Pe | 2000 |
Erythroplasia of queyrat treated by topical aminolaevulinic acid photodynamic therapy: a cautionary tale.
Topics: Adult; Aminolevulinic Acid; Carcinoma, Squamous Cell; Erythroplasia; Humans; Male; Penile Neoplasms; | 2000 |
Effect of photodynamic therapy in combination with ionizing radiation on human squamous cell carcinoma cell lines of the head and neck.
Topics: Aminolevulinic Acid; Carcinoma, Squamous Cell; Cell Cycle; Cell Survival; Combined Modality Therapy; | 2000 |
[Photodynamic therapy for dysphagia due to esophageal carcinoma].
Topics: Adenocarcinoma; Aged; Aged, 80 and over; Aminolevulinic Acid; Carcinoma, Squamous Cell; Deglutition | 1999 |
Photodynamic therapy for in situ squamous cell carcinoma on chronic radiation dermatitis after photosensitization with 5-aminolaevulinic acid.
Topics: Aminolevulinic Acid; Carcinoma in Situ; Carcinoma, Squamous Cell; Fingers; Humans; Male; Middle Aged | 2000 |
Photodynamic therapy of feline superficial squamous cell carcinoma using topical 5-aminolaevulinic acid.
Topics: Administration, Topical; Aminolevulinic Acid; Animals; Carcinoma, Squamous Cell; Cat Diseases; Cats; | 2001 |
[Experimental 5-aminolevulinic acid-induced photodynamic therapy (ALA-PDT) of oral carcinomas. Procedures in treatment of solid tumors and elucidation of cell death].
Topics: Aminolevulinic Acid; Animals; Apoptosis; Carcinoma, Squamous Cell; Humans; Mice; Mice, SCID; Mouth N | 2001 |
Fluorescence staining of oral cancer using a topical application of 5-aminolevulinic acid: fluorescence microscopic studies.
Topics: Aminolevulinic Acid; Carcinoma in Situ; Carcinoma, Squamous Cell; Fluorescence; Humans; Microscopy, | 2001 |
In vitro and in vivo expression of protoporphyrin IX induced by lipophilic 5-aminolevulinic acid derivatives.
Topics: Aminolevulinic Acid; Animals; Carcinoma, Squamous Cell; Cells, Cultured; HeLa Cells; Humans; Keratin | 2001 |
Photosensitization with hematoporphyrin derivative compared to 5-aminolaevulinic acid for photodynamic therapy of esophageal carcinoma.
Topics: Adenocarcinoma; Aged; Aged, 80 and over; Aminolevulinic Acid; Carcinoma, Squamous Cell; Esophageal N | 2001 |
Photodynamic therapy of premalignant lesions and local recurrence of laryngeal and hypopharyngeal cancers.
Topics: Aminolevulinic Acid; Carcinoma, Squamous Cell; Female; Humans; Hypopharyngeal Neoplasms; Laryngeal N | 2001 |
A comparative study of normal inspection, autofluorescence and 5-ALA-induced PPIX fluorescence for oral cancer diagnosis.
Topics: Adult; Aged; Aged, 80 and over; Aminolevulinic Acid; Biopsy; Carcinoma, Squamous Cell; Female; Fluor | 2002 |
[Tumors of the mouth cavity. Not all fluorescent tumors are malignant].
Topics: Aminolevulinic Acid; Carcinoma, Squamous Cell; Diagnosis, Differential; Fluorescence; Humans; Mouth | 2002 |
Photodynamic therapy in patient with xeroderma pigmentosum.
Topics: Administration, Topical; Aminolevulinic Acid; Carcinoma, Squamous Cell; Female; Humans; Middle Aged; | 1991 |
Differential in vitro sensitivity of oral precancerous and squamous cell carcinoma cell lines to 5-aminolevulinic acid-mediated photodynamic therapy.
Topics: Aminolevulinic Acid; Apoptosis; Carcinoma, Squamous Cell; Cell Line, Tumor; Dose-Response Relationsh | 2020 |
Enhanced anti-tumor efficacy of 5-aminolevulinic acid-gold nanoparticles-mediated photodynamic therapy in cutaneous squamous cell carcinoma cells.
Topics: Aminolevulinic Acid; Apoptosis; Carcinoma, Squamous Cell; Cell Line, Tumor; Cell Proliferation; Cell | 2020 |
Modified 5-aminolevulinic acid photodynamic therapy (M-PDT) inhibits cutaneous squamous cell carcinoma cell proliferation via targeting PP2A/PP5-mediated MAPK signaling pathway.
Topics: Aminolevulinic Acid; Apoptosis; Biomarkers, Tumor; Carcinoma, Squamous Cell; Cell Proliferation; Gen | 2021 |