aminolevulinic acid has been researched along with Cancer of Mouth in 60 studies
Aminolevulinic Acid: A compound produced from succinyl-CoA and GLYCINE as an intermediate in heme synthesis. It is used as a PHOTOCHEMOTHERAPY for actinic KERATOSIS.
5-aminolevulinic acid : The simplest delta-amino acid in which the hydrogens at the gamma position are replaced by an oxo group. It is metabolised to protoporphyrin IX, a photoactive compound which accumulates in the skin. Used (in the form of the hydrochloride salt)in combination with blue light illumination for the treatment of minimally to moderately thick actinic keratosis of the face or scalp.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We report the case of a 42-year-old man with concomitant oral leukoplakia and oral submucous fibrosis almost involving the entire right buccal mucosa, who underwent six sessions of topical 5-aminolevulinic acid-mediated photodynamic therapy." | 8.31 | 5-aminolevulinic acid photodynamic therapy for extensive oral leukoplakia with concomitant oral submucous fibrosis: A case report. ( Fang, C; Gao, X; Jiang, C; Li, N; Ma, L; Peng, J; Song, S; Wan, W, 2023) |
| "In conclusion, topical 5-aminolevulinic acid-mediated photodynamic therapy appears safe and has excellent clinical efficacy against oral leukoplakia-concomitant oral submucous fibrosis, but long-term follow-up is necessary." | 8.31 | 5-aminolevulinic acid photodynamic therapy for extensive oral leukoplakia with concomitant oral submucous fibrosis: A case report. ( Fang, C; Gao, X; Jiang, C; Li, N; Ma, L; Peng, J; Song, S; Wan, W, 2023) |
| "Our recent studies showed that a new topical 5-aminolevulinic acid-mediated photodynamic therapy (ALA-PDT) protocol using a light-emitting diode (LED) light source is an effective and successful treatment modality for five cases of oral verrucous hyperplasia (OVH) and one case of verrucous carcinoma." | 7.73 | Successful treatment of oral verrucous hyperplasia and oral leukoplakia with topical 5-aminolevulinic acid-mediated photodynamic therapy. ( Chen, HM; Chiang, CP; Tsai, T; Tu, PC; Yeh, CY; Yu, CH, 2005) |
| "We report the case of a 42-year-old man with concomitant oral leukoplakia and oral submucous fibrosis almost involving the entire right buccal mucosa, who underwent six sessions of topical 5-aminolevulinic acid-mediated photodynamic therapy." | 4.31 | 5-aminolevulinic acid photodynamic therapy for extensive oral leukoplakia with concomitant oral submucous fibrosis: A case report. ( Fang, C; Gao, X; Jiang, C; Li, N; Ma, L; Peng, J; Song, S; Wan, W, 2023) |
| "In conclusion, topical 5-aminolevulinic acid-mediated photodynamic therapy appears safe and has excellent clinical efficacy against oral leukoplakia-concomitant oral submucous fibrosis, but long-term follow-up is necessary." | 4.31 | 5-aminolevulinic acid photodynamic therapy for extensive oral leukoplakia with concomitant oral submucous fibrosis: A case report. ( Fang, C; Gao, X; Jiang, C; Li, N; Ma, L; Peng, J; Song, S; Wan, W, 2023) |
| "Our recent studies showed that a new topical 5-aminolevulinic acid-mediated photodynamic therapy (ALA-PDT) protocol using a light-emitting diode (LED) light source is an effective and successful treatment modality for five cases of oral verrucous hyperplasia (OVH) and one case of verrucous carcinoma." | 3.73 | Successful treatment of oral verrucous hyperplasia and oral leukoplakia with topical 5-aminolevulinic acid-mediated photodynamic therapy. ( Chen, HM; Chiang, CP; Tsai, T; Tu, PC; Yeh, CY; Yu, CH, 2005) |
| "Fluorescence spectroscopy combined with 5-aminolevulinic acid-induced protoporphyrin IX was found as a valuable tool in the diagnosis of oral premalignancy." | 2.72 | Fluorescence spectroscopy combined with 5-aminolevulinic acid-induced protoporphyrin IX fluorescence in detecting oral premalignancy. ( El-Maaytah, M; Hopper, C; Jerjes, W; Khalil, HS; MacRobert, AJ; Salih, V; Sharwani, A, 2006) |
| "Radiogenic oral mucositis has been a concerning side effect of this treatment method." | 1.91 | Topical photodynamic therapy for brachytherapy-induced oral mucositis. ( Cao, J; Chen, X; Liu, R; Wang, X; Zhang, H, 2023) |
| "Oral squamous cell carcinoma (OSCC) can be characterized by severe functional impairment and a poor prognosis." | 1.72 | Nimotuzumab shows an additive effect to inhibit cell growth of ALA-PDT treated oral cancer cells. ( He, X; Hu, L; Hu, N; Wang, X; Wen, N; Yang, S; Yang, Z, 2022) |
| "Additionally, a oral cancer Xenograft model of nude mice was built to test its inhibitive effect on the cancerous growth in vivo." | 1.62 | Co-delivery of chitosan nanoparticles of 5-aminolevulinic acid and shGBAS for improving photodynamic therapy efficacy in oral squamous cell carcinomas. ( Li, S; Liu, H; Wang, X, 2021) |
| "India has one of the highest rates of oral cancer incidence in the world, accounting for 30% of reported cancers." | 1.56 | Clinical evaluation of smartphone-based fluorescence imaging for guidance and monitoring of ALA-PDT treatment of early oral cancer. ( Akhtar, K; Bown, SG; Celli, JP; Cuckov, F; Daly, L; Hasan, SA; Hasan, T; Hopper, C; Hussain, MAB; Khan, AP; Khan, S; Leon, P; Liu, H; Mallidi, S; Rudd, G; Siddiqui, S; Siddiqui, SA, 2020) |
| " In cell culture, we show that the overall dose-response is consistent with established light sources and complete cell death of ALA photosensitized cells can be achieved in the irradiated zone." | 1.51 | Development and evaluation of a low-cost, portable, LED-based device for PDT treatment of early-stage oral cancer in resource-limited settings. ( Celli, JP; Cuckov, F; Daly, L; Hasan, T; Khan, AP; Liu, H; Liu, Y; Mallidi, S; Rudd, G, 2019) |
| "Oral cancer is a common cancer with a high mortality rate." | 1.51 | MAL-PDT inhibits oral precancerous cells and lesions via autophagic cell death. ( Chen, YK; Cheng, KH; Chi, TC; Hu, CS; Huang, WL; Wang, YM; Wang, YY; Xiao, LY; Yuan, SF, 2019) |
| "5-Aminolevulinic acid (5-ALA) is a prodrug used in photodynamic therapy (PDT) of tumors, including cancer of the oral mucosa." | 1.46 | α-Bisabolol improves 5-aminolevulinic acid retention in buccal tissues: Potential application in the photodynamic therapy of oral cancer. ( Campos de Oliveira Miguel, N; Dos Santos Miranda Costa, I; Freiman de Souza Ramos, M; Quintanilha, NP; Riemma Pierre, MB, 2017) |
| "Our previous study showed successful treatment of a large oral verrucous hyperplasia (OVH) with topical 5-aminolevulinic acid-mediated photodynamic therapy combined with cryotherapy (ALA-PDT)." | 1.40 | Successful treatment of oral verrucous hyperplasia with photodynamic therapy combined with cryotherapy--report of 3 cases. ( Chang, YC; Yu, CH, 2014) |
| "After transplanting five human oral squamous carcinoma cell lines into scid mice, the degree of tumor differentiation was evaluated by hematoxylin-and-eosin staining." | 1.35 | [Fluorescence analysis of oral squamous cell carcinoma with 5-aminolevulinic acid labeling]. ( Uekusa, M, 2009) |
| "Patients who have had one oral cancer are at increased risk of developing a further malignant tumour, the detection of which is made difficult (and is often delayed) by the innocuous appearance of the early oral lesion." | 1.35 | Detection of mucosal abnormalities in patients with oral cancer using a photodynamic technique: A pilot study. ( Day, A; Goodman, CR; McLaren, S; O'Dwyer, M; Ogden, GR; Padgett, M, 2008) |
| " Using h-ALA, the peak concentration of protoporphyrin IX was achieved 20%-25% more quickly with 3- or 6-mM solutions than with ALA." | 1.33 | Pharmacokinetics of the photosensitizers aminolevulinic acid and aminolevulinic acid hexylester in oro-facial tumors embedded in the chorioallantois membrane of a hen's egg. ( Foth, HJ; Hoppenheit, C; Hüttenberger, D; Müller-Richter, UD; Reichert, TE; Spitzer, WJ, 2006) |
| "Using h-ALA, the peak concentration of protoporphyrin IX, compared to ALA, is achieved 20% percent more quickly and with twice as much contrast between tumorous and healthy tissue (1:11 compared and 1:5, respectively)." | 1.33 | Pharmacokinetics of the photosensitizers aminolevulinic acid and aminolevulinic acid hexylester in oro-facial tumors embedded in the chorioallantois membrane of a hen's egg. ( Foth, HJ; Hoppenheit, C; Hüttenberger, D; Müller-Richter, UD; Reichert, TE; Spitzer, WJ, 2006) |
| "It will be the aim of further investigations to verify the optimal time of incubation and dosing of systemical 5-ALA application to enhance fluorescence contrasts and set the basis for fluorescence guided resections." | 1.31 | [Fluorescence staining of oral and laryngeal cancer after application of 5-aminolevulinic acid]. ( Baumgartner, R; Betz, CS; Heinrich, P; Janda, P; Leunig, A, 2002) |
| "Of our own patients suffering from oral squamous cell carcinoma (OSCC), 96% possessed a 5-aminolevulinic acid (ALA)-induced tumor fluorescence." | 1.31 | [Experimental 5-aminolevulinic acid-induced photodynamic therapy (ALA-PDT) of oral carcinomas. Procedures in treatment of solid tumors and elucidation of cell death]. ( Berndt, A; Dahse, R; Hyckel, P; Kosmehl, H; Schleier, P; Zenk, W, 2001) |
| "24 patients suffering from oral cancer were included in this investigation." | 1.31 | Fluorescence staining of oral cancer using a topical application of 5-aminolevulinic acid: fluorescence microscopic studies. ( Arbogast, S; Baumgartner, R; Betz, C; Grevers, G; Leunig, A; Mehlmann, M; Stepp, H, 2001) |
| "Protoporphyrin IX fluorescence was detected in the oral mucosa of all patients after local application of 5-ALA." | 1.29 | Fluorescence imaging and spectroscopy of 5-aminolevulinic acid induced protoporphyrin IX for the detection of neoplastic lesions in the oral cavity. ( Alwin, G; Baumgartner, R; Feyh, J; Gutmann, R; Leunig, A; Rick, K; Stepp, H, 1996) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 5 (8.33) | 18.2507 |
| 2000's | 22 (36.67) | 29.6817 |
| 2010's | 23 (38.33) | 24.3611 |
| 2020's | 10 (16.67) | 2.80 |
| Authors | Studies |
|---|---|
| Yao, Y | 1 |
| Shi, L | 1 |
| Wang, Y | 1 |
| Shen, X | 1 |
| Ye, S | 1 |
| Tang, G | 1 |
| Wu, L | 1 |
| Wang, J | 1 |
| Wang, K | 1 |
| Liang, J | 2 |
| Jin, J | 2 |
| Wang, X | 5 |
| Yan, S | 1 |
| He, X | 1 |
| Hu, N | 1 |
| Yang, S | 1 |
| Yang, Z | 1 |
| Hu, L | 1 |
| Wen, N | 1 |
| Zhang, Q | 1 |
| Wang, F | 1 |
| Kuang, W | 1 |
| Zeng, X | 2 |
| Zhang, X | 1 |
| Mendonca, P | 1 |
| Sunny, SP | 1 |
| Mohan, U | 1 |
| Birur N, P | 1 |
| Suresh, A | 1 |
| Kuriakose, MA | 1 |
| Wan, W | 3 |
| Gao, X | 3 |
| Song, S | 3 |
| Peng, J | 3 |
| Jiang, C | 3 |
| Fang, C | 3 |
| Li, N | 3 |
| Ma, L | 3 |
| Chen, X | 1 |
| Cao, J | 1 |
| Zhang, H | 1 |
| Liu, R | 1 |
| Jin, X | 1 |
| Xu, H | 1 |
| Deng, J | 1 |
| Dan, H | 1 |
| Ji, P | 1 |
| Chen, Q | 1 |
| Khan, S | 1 |
| Hussain, MAB | 1 |
| Khan, AP | 2 |
| Liu, H | 4 |
| Siddiqui, S | 1 |
| Mallidi, S | 2 |
| Leon, P | 1 |
| Daly, L | 2 |
| Rudd, G | 2 |
| Cuckov, F | 2 |
| Hopper, C | 5 |
| Bown, SG | 3 |
| Akhtar, K | 1 |
| Hasan, SA | 1 |
| Siddiqui, SA | 1 |
| Hasan, T | 2 |
| Celli, JP | 2 |
| Li, S | 1 |
| Quintanilha, NP | 1 |
| Dos Santos Miranda Costa, I | 1 |
| Freiman de Souza Ramos, M | 1 |
| Campos de Oliveira Miguel, N | 1 |
| Riemma Pierre, MB | 1 |
| Rosin, FCP | 2 |
| Teixeira, MG | 2 |
| Pelissari, C | 2 |
| Corrêa, L | 3 |
| Fang, CY | 1 |
| Chen, PY | 1 |
| Ho, DC | 1 |
| Tsai, LL | 1 |
| Hsieh, PL | 1 |
| Lu, MY | 1 |
| Yu, CC | 1 |
| Yu, CH | 4 |
| Liu, Y | 1 |
| Wang, YY | 1 |
| Chen, YK | 1 |
| Hu, CS | 1 |
| Xiao, LY | 1 |
| Huang, WL | 1 |
| Chi, TC | 1 |
| Cheng, KH | 1 |
| Wang, YM | 1 |
| Yuan, SF | 1 |
| Yamamoto, M | 1 |
| Fujita, H | 1 |
| Katase, N | 1 |
| Inoue, K | 1 |
| Nagatsuka, H | 1 |
| Utsumi, K | 1 |
| Sasaki, J | 1 |
| Ohuchi, H | 1 |
| Barcessat, AR | 1 |
| Huang, I | 1 |
| Rosin, FP | 1 |
| dos Santos Pinto, D | 1 |
| Maria Zezell, D | 1 |
| Calin, MA | 1 |
| Calin, MR | 1 |
| Petrescu, E | 1 |
| Neagu, M | 1 |
| Yang, DF | 4 |
| Lee, JW | 4 |
| Chen, HM | 8 |
| Huang, Z | 2 |
| Hsu, YC | 5 |
| Chang, YC | 1 |
| Chen, JH | 1 |
| Chiang, CP | 9 |
| Liu, CJ | 1 |
| Chang, JL | 1 |
| Costa, Idos S | 1 |
| Abranches, RP | 1 |
| Garcia, MT | 1 |
| Pierre, MB | 1 |
| Uekusa, M | 1 |
| Hamad, LO | 1 |
| Vervoorts, A | 1 |
| Hennig, T | 1 |
| Bayer, R | 1 |
| Moon, YH | 1 |
| Park, JH | 1 |
| Kim, SA | 1 |
| Lee, JB | 1 |
| Ahn, SG | 1 |
| Yoon, JH | 1 |
| Mallia, RJ | 1 |
| Subhash, N | 1 |
| Sebastian, P | 1 |
| Kumar, R | 1 |
| Thomas, SS | 1 |
| Mathews, A | 1 |
| Madhavan, J | 1 |
| Lin, HP | 1 |
| Yang, H | 4 |
| Wang, YP | 3 |
| Liu, CM | 1 |
| Chou, HY | 1 |
| Kuo, MY | 3 |
| Jerjes, W | 2 |
| Upile, T | 1 |
| Hamdoon, Z | 1 |
| Mosse, CA | 1 |
| Akram, S | 1 |
| Jiang, CF | 1 |
| Wang, CY | 1 |
| Tseng, MK | 1 |
| Zheng, W | 3 |
| Soo, KC | 3 |
| Sivanandan, R | 2 |
| Olivo, M | 3 |
| Leunig, A | 6 |
| Betz, CS | 3 |
| Heinrich, P | 1 |
| Janda, P | 2 |
| Baumgartner, R | 6 |
| Ebihara, A | 2 |
| Krasieva, TB | 1 |
| Liaw, LH | 1 |
| Fago, S | 1 |
| Messadi, D | 1 |
| Osann, K | 2 |
| Wilder-Smith, P | 2 |
| Charoenbanpachon, S | 1 |
| Krasieva, T | 1 |
| Tsai, JC | 1 |
| Huang, SB | 1 |
| Wang, CW | 1 |
| Lee, MI | 2 |
| Chen, CT | 3 |
| Tsai, T | 4 |
| Kuo, YS | 2 |
| Lan, WH | 1 |
| Akita, Y | 1 |
| Kozaki, K | 1 |
| Nakagawa, A | 1 |
| Saito, T | 1 |
| Ito, S | 1 |
| Tamada, Y | 1 |
| Fujiwara, S | 1 |
| Nishikawa, N | 1 |
| Uchida, K | 1 |
| Yoshikawa, K | 1 |
| Noguchi, T | 1 |
| Miyaishi, O | 1 |
| Shimozato, K | 1 |
| Saga, S | 1 |
| Matsumoto, Y | 1 |
| Tu, PC | 1 |
| Yeh, CY | 1 |
| Sharwani, A | 1 |
| Salih, V | 1 |
| MacRobert, AJ | 3 |
| El-Maaytah, M | 1 |
| Khalil, HS | 1 |
| Vaidyanathan, V | 1 |
| Wiggs, R | 1 |
| Stohl, J | 1 |
| Baxi, M | 1 |
| Hoppenheit, C | 1 |
| Hüttenberger, D | 1 |
| Foth, HJ | 1 |
| Spitzer, WJ | 1 |
| Reichert, TE | 1 |
| Müller-Richter, UD | 1 |
| Sharma, S | 1 |
| Jajoo, A | 1 |
| Dube, A | 1 |
| O'Dwyer, M | 1 |
| Day, A | 1 |
| Padgett, M | 1 |
| Ogden, GR | 1 |
| McLaren, S | 1 |
| Goodman, CR | 1 |
| Grant, WE | 1 |
| Speight, PM | 2 |
| Fan, KF | 1 |
| Buonaccorsi, G | 1 |
| Rick, K | 2 |
| Stepp, H | 5 |
| Goetz, A | 1 |
| Feyh, J | 2 |
| Gutmann, R | 1 |
| Alwin, G | 1 |
| Zenk, W | 3 |
| Dietel, W | 2 |
| Schleier, P | 3 |
| Günzel, S | 1 |
| Mehlmann, M | 2 |
| Arbogast, S | 3 |
| Grevers, G | 3 |
| Berndt, A | 2 |
| Dahse, R | 1 |
| Hyckel, P | 1 |
| Kosmehl, H | 1 |
| Betz, C | 1 |
| Li, W | 1 |
| Wang, Q | 1 |
| Han, Y | 1 |
2 reviews available for aminolevulinic acid and Cancer of Mouth
| Article | Year |
|---|---|
Non-invasive imaging of oral potentially malignant and malignant lesions: A systematic review and meta-analysis.
Topics: Aminolevulinic Acid; Carcinoma, Squamous Cell; Humans; Mouth Diseases; Mouth Neoplasms; Narrow Band | 2022 |
Photodynamic therapy for oral potentially malignant disorders.
Topics: Aminolevulinic Acid; Humans; Lasers, Semiconductor; Methylene Blue; Mouth Diseases; Mouth Neoplasms; | 2019 |
3 trials available for aminolevulinic acid and Cancer of Mouth
| Article | Year |
|---|---|
Ablative fractional laser-assisted photodynamic therapy vs. ablative fractional laser for oral leukoplakia treatment: A randomized, controlled pilot study.
Topics: Aminolevulinic Acid; Carcinoma, Squamous Cell; Humans; Laser Therapy; Lasers, Solid-State; Leukoplak | 2021 |
Photodynamic therapy outcome for oral dysplasia.
Topics: Aged; Aminolevulinic Acid; Carcinoma in Situ; Drug Administration Schedule; Female; Humans; Lasers, | 2011 |
Fluorescence spectroscopy combined with 5-aminolevulinic acid-induced protoporphyrin IX fluorescence in detecting oral premalignancy.
Topics: Adult; Aged; Aged, 80 and over; Aminolevulinic Acid; Biopsy; Humans; Middle Aged; Mouth Neoplasms; P | 2006 |
55 other studies available for aminolevulinic acid and Cancer of Mouth
| Article | Year |
|---|---|
Chitosan-tripolyphosphate nanoparticles-mediated co-delivery of MTHFD1L shRNA and 5-aminolevulinic acid for combination photodynamic-gene therapy in oral cancer.
Topics: Aminolevulinic Acid; Animals; Carcinoma, Squamous Cell; Cell Line, Tumor; Chitosan; Genetic Therapy; | 2021 |
Nimotuzumab shows an additive effect to inhibit cell growth of ALA-PDT treated oral cancer cells.
Topics: Aminolevulinic Acid; Antibodies, Monoclonal, Humanized; Apoptosis; Carcinoma, Squamous Cell; Cell Li | 2022 |
Photodynamic therapy for extensive oral verrucous/granular leukoplakia with moderate-to-severe dysplasia: A case study.
Topics: Aminolevulinic Acid; Cell Transformation, Neoplastic; Humans; Leukoplakia, Oral; Male; Middle Aged; | 2022 |
5-aminolevulinic acid photodynamic therapy for extensive oral leukoplakia with concomitant oral submucous fibrosis: A case report.
Topics: Adult; Aminolevulinic Acid; Humans; Leukoplakia, Oral; Male; Mouth Neoplasms; Oral Submucous Fibrosi | 2023 |
5-aminolevulinic acid photodynamic therapy for extensive oral leukoplakia with concomitant oral submucous fibrosis: A case report.
Topics: Adult; Aminolevulinic Acid; Humans; Leukoplakia, Oral; Male; Mouth Neoplasms; Oral Submucous Fibrosi | 2023 |
5-aminolevulinic acid photodynamic therapy for extensive oral leukoplakia with concomitant oral submucous fibrosis: A case report.
Topics: Adult; Aminolevulinic Acid; Humans; Leukoplakia, Oral; Male; Mouth Neoplasms; Oral Submucous Fibrosi | 2023 |
5-aminolevulinic acid photodynamic therapy for extensive oral leukoplakia with concomitant oral submucous fibrosis: A case report.
Topics: Adult; Aminolevulinic Acid; Humans; Leukoplakia, Oral; Male; Mouth Neoplasms; Oral Submucous Fibrosi | 2023 |
5-aminolevulinic acid photodynamic therapy for extensive oral leukoplakia with concomitant oral submucous fibrosis: A case report.
Topics: Adult; Aminolevulinic Acid; Humans; Leukoplakia, Oral; Male; Mouth Neoplasms; Oral Submucous Fibrosi | 2023 |
5-aminolevulinic acid photodynamic therapy for extensive oral leukoplakia with concomitant oral submucous fibrosis: A case report.
Topics: Adult; Aminolevulinic Acid; Humans; Leukoplakia, Oral; Male; Mouth Neoplasms; Oral Submucous Fibrosi | 2023 |
5-aminolevulinic acid photodynamic therapy for extensive oral leukoplakia with concomitant oral submucous fibrosis: A case report.
Topics: Adult; Aminolevulinic Acid; Humans; Leukoplakia, Oral; Male; Mouth Neoplasms; Oral Submucous Fibrosi | 2023 |
5-aminolevulinic acid photodynamic therapy for extensive oral leukoplakia with concomitant oral submucous fibrosis: A case report.
Topics: Adult; Aminolevulinic Acid; Humans; Leukoplakia, Oral; Male; Mouth Neoplasms; Oral Submucous Fibrosi | 2023 |
5-aminolevulinic acid photodynamic therapy for extensive oral leukoplakia with concomitant oral submucous fibrosis: A case report.
Topics: Adult; Aminolevulinic Acid; Humans; Leukoplakia, Oral; Male; Mouth Neoplasms; Oral Submucous Fibrosi | 2023 |
Topical photodynamic therapy for brachytherapy-induced oral mucositis.
Topics: Administration, Topical; Aged; Aminolevulinic Acid; Brachytherapy; Humans; Iodine Radioisotopes; Mal | 2023 |
Clinical evaluation of smartphone-based fluorescence imaging for guidance and monitoring of ALA-PDT treatment of early oral cancer.
Topics: Aminolevulinic Acid; Carcinoma, Squamous Cell; Humans; Mouth Neoplasms; Optical Imaging; Photochemot | 2020 |
Co-delivery of chitosan nanoparticles of 5-aminolevulinic acid and shGBAS for improving photodynamic therapy efficacy in oral squamous cell carcinomas.
Topics: Aminolevulinic Acid; Animals; Carcinoma, Squamous Cell; Cell Line, Tumor; Chitosan; Head and Neck Ne | 2021 |
α-Bisabolol improves 5-aminolevulinic acid retention in buccal tissues: Potential application in the photodynamic therapy of oral cancer.
Topics: Aminolevulinic Acid; Animals; Drug Compounding; Light; Monocyclic Sesquiterpenes; Mouth Mucosa; Mout | 2017 |
Resistance of oral cancer cells to 5-ALA-mediated photodynamic therapy.
Topics: Aminolevulinic Acid; Apoptosis; Blotting, Western; Cell Line, Tumor; Cell Movement; Cell Proliferati | 2018 |
miR-145 mediates the anti-cancer stemness effect of photodynamic therapy with 5-aminolevulinic acid (ALA) in oral cancer cells.
Topics: Aminolevulinic Acid; Cell Line, Tumor; Humans; Hyaluronan Receptors; MicroRNAs; Mouth Neoplasms; Neo | 2018 |
Development and evaluation of a low-cost, portable, LED-based device for PDT treatment of early-stage oral cancer in resource-limited settings.
Topics: Aminolevulinic Acid; Animals; Antineoplastic Agents; Carcinoma, Squamous Cell; Cell Line, Tumor; Dev | 2019 |
Photodynamic Therapy Mediated by 5-aminolevulinic Acid Promotes the Upregulation and Modifies the Intracellular Expression of Surveillance Proteins in Oral Squamous Cell Carcinoma.
Topics: Aminolevulinic Acid; Carcinoma, Squamous Cell; Humans; Mouth Neoplasms; Photochemotherapy; Photosens | 2019 |
MAL-PDT inhibits oral precancerous cells and lesions via autophagic cell death.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Aminolevulinic Acid; Animals; Autophagosomes; Autophagy; Body Weig | 2019 |
Improvement of the efficacy of 5-aminolevulinic acid-mediated photodynamic treatment in human oral squamous cell carcinoma HSC-4.
Topics: Amino Acid Chloromethyl Ketones; Aminolevulinic Acid; Apoptosis; ATP Binding Cassette Transporter, S | 2013 |
Effect of topical 5-ALA mediated photodynamic therapy on proliferation index of keratinocytes in 4-NQO-induced potentially malignant oral lesions.
Topics: 4-Nitroquinoline-1-oxide; Administration, Topical; Aminolevulinic Acid; Animals; Apoptosis; Cell Pro | 2013 |
Increased number of fractionated irradiation sessions does not improve the cellular response to methyl aminolevulinate-mediated photodynamic therapy.
Topics: Aminolevulinic Acid; Cell Line, Tumor; Dose Fractionation, Radiation; Dose-Response Relationship, Ra | 2013 |
Methotrexate enhances 5-aminolevulinic acid-mediated photodynamic therapy-induced killing of human SCC4 cells by upregulation of coproporphyrinogen oxidase.
Topics: Aminolevulinic Acid; Carcinoma, Squamous Cell; Coproporphyrinogen Oxidase; Humans; Methotrexate; Mou | 2014 |
Successful treatment of oral verrucous hyperplasia with photodynamic therapy combined with cryotherapy--report of 3 cases.
Topics: Adult; Aminolevulinic Acid; Carcinoma, Verrucous; Combined Modality Therapy; Cryotherapy; Humans; Ma | 2014 |
Topical methotrexate pretreatment enhances the therapeutic effect of topical 5-aminolevulinic acid-mediated photodynamic therapy on hamster buccal pouch precancers.
Topics: Administration, Topical; Aminolevulinic Acid; Animals; Cricetinae; Immunosuppressive Agents; Male; M | 2014 |
Improve efficacy of topical ALA-PDT by calcipotriol through up-regulation of coproporphyrinogen oxidase.
Topics: Administration, Topical; Aminolevulinic Acid; Animals; Calcitriol; Cell Line, Tumor; Cheek; Cricetin | 2014 |
Chitosan-based mucoadhesive films containing 5-aminolevulinic acid for buccal cancer's treatment.
Topics: Adhesives; Aminolevulinic Acid; Animals; Chitosan; Drug Liberation; Mouth Mucosa; Mouth Neoplasms; P | 2014 |
[Fluorescence analysis of oral squamous cell carcinoma with 5-aminolevulinic acid labeling].
Topics: Aminolevulinic Acid; Animals; Carcinoma, Squamous Cell; Fluorescence; Humans; Mice; Mice, SCID; Mout | 2009 |
Ex vivo photodynamic diagnosis to detect malignant cells in oral brush biopsies.
Topics: Adolescent; Adult; Aminolevulinic Acid; Biopsy; Cell Line, Tumor; Chlorhexidine; Cytodiagnosis; Huma | 2010 |
Anticancer effect of photodynamic therapy with hexenyl ester of 5-aminolevulinic acid in oral squamous cell carcinoma.
Topics: Aminolevulinic Acid; Blotting, Western; Carcinoma, Squamous Cell; Caspase 3; Cell Death; Cell Surviv | 2010 |
In vivo temporal evolution of ALA-induced normalized fluorescence at different anatomical locations of oral cavity: application to improve cancer diagnostic contrast and potential.
Topics: Administration, Topical; Aminolevulinic Acid; Carcinoma, Squamous Cell; Diagnosis, Oral; Humans; Mou | 2010 |
Topical photodynamic therapy is very effective for oral verrucous hyperplasia and oral erythroleukoplakia.
Topics: Adult; Aged; Aged, 80 and over; Aminolevulinic Acid; Biopsy; Carcinoma in Situ; Erythroplasia; Femal | 2010 |
5-aminolevulinic acid induce apoptosis via NF-κB/JNK pathway in human oral cancer Ca9-22 cells.
Topics: Aminolevulinic Acid; Apoptosis; Caspase Inhibitors; Cell Line, Tumor; Fas-Associated Death Domain Pr | 2011 |
Comparative study of protoporphyrin IX fluorescence image enhancement methods to improve an optical imaging system for oral cancer detection.
Topics: Aminolevulinic Acid; Diagnostic Imaging; Fluorescence; Humans; Image Enhancement; Mouth Neoplasms; O | 2011 |
Successful treatment of 7,12-dimethylbenz(a)anthracene-induced hamster buccal pouch precancerous lesions by topical 5-aminolevulinic acid-mediated photodynamic therapy.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Aminolevulinic Acid; Animals; Cheek; Cricetinae; Male; Mesocricetu | 2012 |
Detection of squamous cell carcinomas and pre-cancerous lesions in the oral cavity by quantification of 5-aminolevulinic acid induced fluorescence endoscopic images.
Topics: Adult; Aged; Aged, 80 and over; Algorithms; Aminolevulinic Acid; Carcinoma, Squamous Cell; Diagnosti | 2002 |
Detection of neoplasms in the oral cavity by digitized endoscopic imaging of 5-aminolevulinic acid-induced protoporphyrin IX fluorescence.
Topics: Adult; Aged; Aged, 80 and over; Algorithms; Aminolevulinic Acid; Endoscopy; Female; Fluorescent Dyes | 2002 |
[Fluorescence staining of oral and laryngeal cancer after application of 5-aminolevulinic acid].
Topics: Administration, Inhalation; Administration, Oral; Aminolevulinic Acid; Biopsy; Carcinoma, Squamous C | 2002 |
Detection and diagnosis of oral cancer by light-induced fluorescence.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Aminolevulinic Acid; Animals; Carcinogens; Carcinoma, Squamous Cel | 2003 |
Acceleration of ALA-induced PpIX fluorescence development in the oral mucosa.
Topics: Administration, Topical; Aminolevulinic Acid; Analysis of Variance; Animals; Carcinoma, Squamous Cel | 2003 |
Photodynamic Therapy of oral dysplasia with topical 5-aminolevulinic acid and light-emitting diode array.
Topics: Administration, Topical; Adult; Aminolevulinic Acid; Animals; Cricetinae; Equipment Design; Female; | 2004 |
Successful treatment of oral verrucous hyperplasia with topical 5-aminolevulinic acid-mediated photodynamic therapy.
Topics: Adult; Aminolevulinic Acid; Humans; Hyperplasia; Male; Middle Aged; Mouth Diseases; Mouth Neoplasms; | 2004 |
The use of digitized endoscopic imaging of 5-ALA-induced PPIX fluorescence to detect and diagnose oral premalignant and malignant lesions in vivo.
Topics: Adult; Aged; Aged, 80 and over; Aminolevulinic Acid; Diagnostic Imaging; Endoscopy; Female; Fluoresc | 2004 |
Cyclooxygenase-2 is a possible target of treatment approach in conjunction with photodynamic therapy for various disorders in skin and oral cavity.
Topics: Aminolevulinic Acid; Bowen's Disease; Carcinoma, Squamous Cell; Cell Division; Cell Line, Tumor; Cyc | 2004 |
Successful treatment of an extensive verrucous carcinoma with topical 5-aminolevulinic acid-mediated photodynamic therapy.
Topics: Administration, Topical; Aminolevulinic Acid; Carcinoma, Verrucous; Dose Fractionation, Radiation; F | 2005 |
Successful treatment of oral verrucous hyperplasia and oral leukoplakia with topical 5-aminolevulinic acid-mediated photodynamic therapy.
Topics: Administration, Topical; Adult; Aged; Aminolevulinic Acid; Carcinoma, Verrucous; Drug Administration | 2005 |
ALA-induced fluorescence in the canine oral cavity.
Topics: Aminolevulinic Acid; Animals; Dogs; Fluorescence; Gingivitis; Mouth Neoplasms; Photosensitizing Agen | 2006 |
Pharmacokinetics of the photosensitizers aminolevulinic acid and aminolevulinic acid hexylester in oro-facial tumors embedded in the chorioallantois membrane of a hen's egg.
Topics: Adult; Aged; Aged, 80 and over; Aminolevulinic Acid; Animals; Biopsy; Carcinoma, Squamous Cell; Chic | 2006 |
5-Aminolevulinic acid-induced protoporphyrin-IX accumulation and associated phototoxicity in macrophages and oral cancer cell lines.
Topics: Aminolevulinic Acid; Animals; Biological Assay; Carcinoma, Transitional Cell; Cell Line, Tumor; Huma | 2007 |
Detection of mucosal abnormalities in patients with oral cancer using a photodynamic technique: A pilot study.
Topics: Aged; Aged, 80 and over; Aminolevulinic Acid; Carcinoma, Squamous Cell; Female; Humans; Male; Middle | 2008 |
Photodynamic therapy of oral cancer: photosensitisation with systemic aminolaevulinic acid.
Topics: Administration, Oral; Aminolevulinic Acid; Carcinoma, Squamous Cell; Fluorescence; Humans; Laser The | 1993 |
Photodynamic therapy using 5-aminolevulinic acid for premalignant and malignant lesions of the oral cavity.
Topics: Aged; Aged, 80 and over; Aminolevulinic Acid; Carcinoma, Squamous Cell; Female; Follow-Up Studies; H | 1996 |
[Photodynamic diagnosis of neoplasms of the mouth cavity after local administration of 5-aminolevulinic acid].
Topics: Administration, Topical; Aged; Aminolevulinic Acid; Carcinoma, Squamous Cell; Female; Fluorescence; | 1996 |
Fluorescence imaging and spectroscopy of 5-aminolevulinic acid induced protoporphyrin IX for the detection of neoplastic lesions in the oral cavity.
Topics: Administration, Topical; Aminolevulinic Acid; Carcinoma, Squamous Cell; Endoscopy; Humans; Middle Ag | 1996 |
[Visualizing carcinomas of the mouth cavity by stimulating synthesis of fluorescent protoporphyrin IX].
Topics: Adult; Aged; Aged, 80 and over; Aminolevulinic Acid; Biopsy; Female; Humans; Male; Middle Aged; Mout | 1999 |
Detection of squamous cell carcinoma of the oral cavity by imaging 5-aminolevulinic acid-induced protoporphyrin IX fluorescence.
Topics: Adult; Aged; Aminolevulinic Acid; Biopsy; Carcinoma, Squamous Cell; Humans; Middle Aged; Mouth; Mout | 2000 |
[Experimental 5-aminolevulinic acid-induced photodynamic therapy (ALA-PDT) of oral carcinomas. Procedures in treatment of solid tumors and elucidation of cell death].
Topics: Aminolevulinic Acid; Animals; Apoptosis; Carcinoma, Squamous Cell; Humans; Mice; Mice, SCID; Mouth N | 2001 |
Fluorescence staining of oral cancer using a topical application of 5-aminolevulinic acid: fluorescence microscopic studies.
Topics: Aminolevulinic Acid; Carcinoma in Situ; Carcinoma, Squamous Cell; Fluorescence; Humans; Microscopy, | 2001 |
A comparative study of normal inspection, autofluorescence and 5-ALA-induced PPIX fluorescence for oral cancer diagnosis.
Topics: Adult; Aged; Aged, 80 and over; Aminolevulinic Acid; Biopsy; Carcinoma, Squamous Cell; Female; Fluor | 2002 |
[Tumors of the mouth cavity. Not all fluorescent tumors are malignant].
Topics: Aminolevulinic Acid; Carcinoma, Squamous Cell; Diagnosis, Differential; Fluorescence; Humans; Mouth | 2002 |
Differential in vitro sensitivity of oral precancerous and squamous cell carcinoma cell lines to 5-aminolevulinic acid-mediated photodynamic therapy.
Topics: Aminolevulinic Acid; Apoptosis; Carcinoma, Squamous Cell; Cell Line, Tumor; Dose-Response Relationsh | 2020 |