aminolevulinic acid has been researched along with Breast Neoplasms in 49 studies
Aminolevulinic Acid: A compound produced from succinyl-CoA and GLYCINE as an intermediate in heme synthesis. It is used as a PHOTOCHEMOTHERAPY for actinic KERATOSIS.
5-aminolevulinic acid : The simplest delta-amino acid in which the hydrogens at the gamma position are replaced by an oxo group. It is metabolised to protoporphyrin IX, a photoactive compound which accumulates in the skin. Used (in the form of the hydrochloride salt)in combination with blue light illumination for the treatment of minimally to moderately thick actinic keratosis of the face or scalp.
Breast Neoplasms: Tumors or cancer of the human BREAST.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Given that Vitamin D (VD) has been confirmed to reinforce the toxic effects of 5-aminolevulinic acid-based photodynamic therapy (ALA-PDT) towards breast cancer, this study was designed to decipher the combined effects of VD, ALA-PDT and paclitaxel (PTX)." | 8.12 | Vitamin D enhances the sensitivity of breast cancer cells to the combination therapy of photodynamic therapy and paclitaxel. ( Liu, X; Lv, H; Shen, H, 2022) |
| "The studied nanoparticles present the potential to deliver aminolevulinic acid to breast cancer cells efficiently, generate singlet oxygen, and convert ALA into PpIX inside the cells allowing photodiagnosis and therapies such as photodynamic and sonodynamic therapies." | 7.96 | Uptake of silver, gold, and hybrids silver-iron, gold-iron and silver-gold aminolevulinic acid nanoparticles by MCF-7 breast cancer cells. ( Bydlowski, SP; Courrol, LC; de Oliveira Gonçalves, K; Levy, D; Vieira, DP, 2020) |
| " This research aimed to assess the cytogenetic potential of 5-aminolevulinic acid (5-ALA) activated with laser irradiation (5-ALA/PDT) to damage the intact DNA of adenocarcinoma breast cancer cell line (MCF-7) and hepatocellular carcinoma cell line (HepG2)." | 7.88 | Photodynamic therapy using 5-aminolevulinic acid triggered DNA damage of adenocarcinoma breast cancer and hepatocellular carcinoma cell lines. ( Abo-Elfadl, MT; Abo-Zeid, MAM; Mostafa, SM, 2018) |
| "By selecting four breast cancer cell lines that represent the main breast tumor subtypes, we investigated their ability to accumulate the fluorescent protoporphyrin IX upon treatment with the marketed 5-aminolevulinic acid hexyl ester (ALA-Hex) or our new and more stable derivative PSI-ALA-Hex." | 5.72 | Enlarging the Scope of 5-Aminolevulinic Acid-Mediated Photodiagnosis towards Breast Cancers. ( Kiening, M; Lange, N, 2022) |
| "5-Aminolevulinic acid (ALA) is a natural heme precursor metabolized into protoporphyrin IX (PpIX)." | 5.40 | Synergistic apoptotic effect of Doxil ® and aminolevulinic acid-based photodynamic therapy on human breast adenocarcinoma cells. ( El-Daly, SM; Gamal-Eldeen, AM; Saleh, S; Zakaria, S, 2014) |
| "This study utilized two breast cancer cell lines differing only in their expression of heat shock protein 27 (hsp27)." | 5.34 | Heat shock protein 27 protects against aminolevulinic acid-mediated photodynamic therapy-induced apoptosis and necrosis in human breast cancer cells. ( Carper, SW; Loucks, C; Madsen, SJ; Ziegler, SA, 2007) |
| "We have reviewed the results of clinical investigations into the use of photodynamic therapy (PDT) with intravenous injection of hematoporphyrin derivative (HpD), Photofrin (PF) and Sn-protoporphyrin (Sn-Pp) or oral administration of delta-aminolevulinic acid in the treatment of skin cancers and/or psoriasis." | 4.79 | Photodynamic therapy with systemic administration of photosensitizers in dermatology. ( Calzavara-Pinton, PG; Ortel, B; Szeimies, RM; Zane, C, 1996) |
| "Given that Vitamin D (VD) has been confirmed to reinforce the toxic effects of 5-aminolevulinic acid-based photodynamic therapy (ALA-PDT) towards breast cancer, this study was designed to decipher the combined effects of VD, ALA-PDT and paclitaxel (PTX)." | 4.12 | Vitamin D enhances the sensitivity of breast cancer cells to the combination therapy of photodynamic therapy and paclitaxel. ( Liu, X; Lv, H; Shen, H, 2022) |
| " For the first time, the aim of this study was to explore the therapeutic effects of 5-aminolevulinic acid (5-ALA)-mediated PDT after LED irradiation on two sub-types (a poorly aggressive MCF-7 and a highly aggressive MDA-MB-231) of breast cancer cell lines." | 4.02 | Investigation of LED-based photodynamic therapy efficiency on breast cancer cells. ( Deveci Ozkan, A; Guney Eskiler, G; Kamanlı, AF; Özyol, E; Sozen Kucukkara, E; Yıldız, MZ, 2021) |
| "The studied nanoparticles present the potential to deliver aminolevulinic acid to breast cancer cells efficiently, generate singlet oxygen, and convert ALA into PpIX inside the cells allowing photodiagnosis and therapies such as photodynamic and sonodynamic therapies." | 3.96 | Uptake of silver, gold, and hybrids silver-iron, gold-iron and silver-gold aminolevulinic acid nanoparticles by MCF-7 breast cancer cells. ( Bydlowski, SP; Courrol, LC; de Oliveira Gonçalves, K; Levy, D; Vieira, DP, 2020) |
| " This research aimed to assess the cytogenetic potential of 5-aminolevulinic acid (5-ALA) activated with laser irradiation (5-ALA/PDT) to damage the intact DNA of adenocarcinoma breast cancer cell line (MCF-7) and hepatocellular carcinoma cell line (HepG2)." | 3.88 | Photodynamic therapy using 5-aminolevulinic acid triggered DNA damage of adenocarcinoma breast cancer and hepatocellular carcinoma cell lines. ( Abo-Elfadl, MT; Abo-Zeid, MAM; Mostafa, SM, 2018) |
| " The objective of this study is to evaluate the effects of Dkk-3 and 5-aminolevulinic acid (5-ALA) mediated photodynamic therapy in breast cancer cell line." | 3.83 | Antitumor effect of combined Dkk-3 and 5-ALA mediated photodynamic therapy in breast cancer cell's colony. ( Fekrazad, R; Mohammadpour, H, 2016) |
| " We recently showed that irradiating breast cancer COH-BR1 cells after treating with 5-aminolevulinic acid (ALA, a pro-sensitizer) resulted in rapid upregulation of inducible nitric oxide (NO) synthase (iNOS)." | 3.79 | Cytoprotective signaling associated with nitric oxide upregulation in tumor cells subjected to photodynamic therapy-like oxidative stress. ( Bhowmick, R; Girotti, AW, 2013) |
| "A photodynamic technique for human breast cancer detection founded upon the ability of tumour cells to rapidly accumulate the fluorescent product protoporphyrin IX (PpIX) has been applied to transgenic mouse models of mammary tumorigenesis." | 3.73 | Early neoplastic and metastatic mammary tumours of transgenic mice detected by 5-aminolevulinic acid-stimulated protoporphyrin IX accumulation. ( Beamer, WG; Dorward, AM; Duffy, TM; Fancher, KS; Walt, H, 2005) |
| "For large areas of Bowen's disease, particularly in anatomically difficult areas and in elderly patients, PDT using ALA may constitute a single simple alternative outpatient treatment to existing therapies." | 2.67 | Superficial photodynamic therapy with topical 5-aminolaevulinic acid for superficial primary and secondary skin cancer. ( Ash, DV; Brown, SB; Cairnduff, F; Hudson, EJ; Stringer, MR, 1994) |
| "Bowen's disease was highly responsive, provided that adequate light and HpD or PF doses were delivered." | 2.39 | Photodynamic therapy with systemic administration of photosensitizers in dermatology. ( Calzavara-Pinton, PG; Ortel, B; Szeimies, RM; Zane, C, 1996) |
| "By selecting four breast cancer cell lines that represent the main breast tumor subtypes, we investigated their ability to accumulate the fluorescent protoporphyrin IX upon treatment with the marketed 5-aminolevulinic acid hexyl ester (ALA-Hex) or our new and more stable derivative PSI-ALA-Hex." | 1.72 | Enlarging the Scope of 5-Aminolevulinic Acid-Mediated Photodiagnosis towards Breast Cancers. ( Kiening, M; Lange, N, 2022) |
| "Aminolevulinic acid (ALA) is a prodrug that is metabolized in the heme biosynthesis pathway to produce protoporphyrin IX (PpIX) for tumor fluorescence detection and photodynamic therapy (PDT)." | 1.51 | Ferrochelatase Deficiency Abrogated the Enhancement of Aminolevulinic Acid-mediated Protoporphyrin IX by Iron Chelator Deferoxamine. ( Braun, A; Chen, B; Howley, R; Kraus, D; Mansi, M; Myers, KA; Palasuberniam, P, 2019) |
| " The main disadvantage of this therapy is that ALA is poorly absorbed by cells due to its high hydrophilicity." | 1.42 | Design, synthesis and biological evaluation of 5-aminolaevulinic acid/3-hydroxypyridinone conjugates as potential photodynamic therapeutical agents. ( Battah, S; Hider, RC; Kong, X; Reeder, BJ; Zhou, T; Zhu, CF, 2015) |
| "5-Aminolevulinic acid (ALA) is a natural heme precursor metabolized into protoporphyrin IX (PpIX)." | 1.40 | Synergistic apoptotic effect of Doxil ® and aminolevulinic acid-based photodynamic therapy on human breast adenocarcinoma cells. ( El-Daly, SM; Gamal-Eldeen, AM; Saleh, S; Zakaria, S, 2014) |
| "We recently showed that irradiating breast cancer COH-BR1 cells after treating with 5-aminolevulinic acid (ALA, a pro-sensitizer) resulted in rapid upregulation of inducible nitric oxide (NO) synthase (iNOS)." | 1.39 | Cytoprotective signaling associated with nitric oxide upregulation in tumor cells subjected to photodynamic therapy-like oxidative stress. ( Bhowmick, R; Girotti, AW, 2013) |
| "Multi-drug resistance of breast cancer is a major obstacle in chemotherapy of cancer treatments." | 1.37 | Modulating ALA-PDT efficacy of mutlidrug resistant MCF-7 breast cancer cells using ALA prodrug. ( Berkovitch-Luria, G; Feuerstein, T; Malik, Z; Nudelman, A; Rephaeli, A, 2011) |
| "This study utilized two breast cancer cell lines differing only in their expression of heat shock protein 27 (hsp27)." | 1.34 | Heat shock protein 27 protects against aminolevulinic acid-mediated photodynamic therapy-induced apoptosis and necrosis in human breast cancer cells. ( Carper, SW; Loucks, C; Madsen, SJ; Ziegler, SA, 2007) |
| "A photodynamic technique for human breast cancer detection founded upon the ability of tumour cells to rapidly accumulate the fluorescent product protoporphyrin IX (PpIX) has been applied to transgenic mouse models of mammary tumorigenesis." | 1.33 | Early neoplastic and metastatic mammary tumours of transgenic mice detected by 5-aminolevulinic acid-stimulated protoporphyrin IX accumulation. ( Beamer, WG; Dorward, AM; Duffy, TM; Fancher, KS; Walt, H, 2005) |
| "Aminolevulinic acid was administered at a concentration of 40 mg kg(-1)bodyweight 150-420 min prior to tumourectomy." | 1.31 | Photodynamic diagnosis of breast tumours after oral application of aminolevulinic acid. ( Allemann, J; Haller, U; Ladner, DP; Steiner, RA; Walt, H, 2001) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 4 (8.16) | 18.2507 |
| 2000's | 13 (26.53) | 29.6817 |
| 2010's | 21 (42.86) | 24.3611 |
| 2020's | 11 (22.45) | 2.80 |
| Authors | Studies |
|---|---|
| Liu, X | 1 |
| Lv, H | 1 |
| Shen, H | 1 |
| Kiening, M | 2 |
| Lange, N | 2 |
| Matsumura, H | 1 |
| Shen, LT | 1 |
| Isozaki, A | 1 |
| Mikami, H | 1 |
| Yuan, D | 1 |
| Miura, T | 1 |
| Kondo, Y | 1 |
| Mori, T | 1 |
| Kusumoto, Y | 1 |
| Nishikawa, M | 1 |
| Yasumoto, A | 1 |
| Ueda, A | 1 |
| Bando, H | 1 |
| Hara, H | 1 |
| Liu, Y | 1 |
| Deng, Y | 1 |
| Sonoshita, M | 1 |
| Yatomi, Y | 1 |
| Goda, K | 1 |
| Matsusaka, S | 1 |
| Vinita, NM | 1 |
| Devan, U | 1 |
| Durgadevi, S | 1 |
| Anitha, S | 1 |
| Prabhu, D | 1 |
| Rajamanikandan, S | 1 |
| Govarthanan, M | 1 |
| Yuvaraj, A | 1 |
| Biruntha, M | 1 |
| Antony Joseph Velanganni, A | 1 |
| Jeyakanthan, J | 1 |
| Prakash, PA | 1 |
| Mohamed Jaabir, MS | 1 |
| Kumar, P | 1 |
| de Andrade, LR | 1 |
| Tedesco, AC | 1 |
| Primo, FL | 1 |
| Farias, GR | 1 |
| da Silva, JR | 1 |
| Longo, JP | 1 |
| de Almeida, MC | 1 |
| de Souza, PE | 1 |
| de Azevedo, RB | 1 |
| Pinheiro, WO | 1 |
| Lacava, ZG | 1 |
| Kamanlı, AF | 1 |
| Yıldız, MZ | 1 |
| Özyol, E | 1 |
| Deveci Ozkan, A | 1 |
| Sozen Kucukkara, E | 1 |
| Guney Eskiler, G | 1 |
| Grosenick, D | 1 |
| Bremer, C | 1 |
| de Oliveira Gonçalves, K | 1 |
| Vieira, DP | 1 |
| Levy, D | 1 |
| Bydlowski, SP | 1 |
| Courrol, LC | 1 |
| Zhou, X | 1 |
| Zheng, M | 1 |
| Zou, Y | 1 |
| Wang, J | 2 |
| Zhang, L | 1 |
| Yin, R | 1 |
| Carter, S | 1 |
| Miller, J | 1 |
| Cramer, G | 1 |
| Yuan, M | 1 |
| Guzman, S | 1 |
| Putt, ME | 1 |
| Cengel, KA | 1 |
| Freedman, GM | 1 |
| Busch, TM | 1 |
| Ottolino-Perry, K | 1 |
| Shahid, A | 1 |
| DeLuca, S | 1 |
| Son, V | 1 |
| Sukhram, M | 1 |
| Meng, F | 1 |
| Liu, ZA | 1 |
| Rapic, S | 1 |
| Anantha, NT | 1 |
| Wang, SC | 1 |
| Chamma, E | 1 |
| Gibson, C | 1 |
| Medeiros, PJ | 1 |
| Majeed, S | 1 |
| Chu, A | 1 |
| Wignall, O | 1 |
| Pizzolato, A | 1 |
| Rosen, CF | 1 |
| Teene, LL | 1 |
| Starr-Dunham, D | 1 |
| Kulbatski, I | 1 |
| Panzarella, T | 1 |
| Done, SJ | 1 |
| Easson, AM | 1 |
| Leong, WL | 1 |
| DaCosta, RS | 1 |
| Abo-Zeid, MAM | 1 |
| Abo-Elfadl, MT | 1 |
| Mostafa, SM | 1 |
| Papanikolaou, M | 1 |
| Tsianou, Z | 1 |
| Skellett, AM | 1 |
| Murphy, J | 1 |
| Millington, GWM | 1 |
| Wang, Y | 1 |
| Yang, M | 1 |
| Qian, J | 1 |
| Xu, W | 1 |
| Hou, G | 1 |
| Ji, L | 1 |
| Suo, A | 1 |
| Alkarakooly, Z | 1 |
| Al-Anbaky, QA | 1 |
| Kannan, K | 1 |
| Ali, N | 1 |
| Palasuberniam, P | 2 |
| Kraus, D | 1 |
| Mansi, M | 1 |
| Braun, A | 1 |
| Howley, R | 1 |
| Myers, KA | 2 |
| Chen, B | 2 |
| Morita, M | 1 |
| Tanaka, H | 1 |
| Kumamoto, Y | 1 |
| Nakamura, A | 1 |
| Harada, Y | 1 |
| Ogata, T | 1 |
| Sakaguchi, K | 1 |
| Taguchi, T | 1 |
| Takamatsu, T | 1 |
| Zakaria, S | 1 |
| Gamal-Eldeen, AM | 1 |
| El-Daly, SM | 1 |
| Saleh, S | 1 |
| Zhu, CF | 1 |
| Battah, S | 1 |
| Kong, X | 1 |
| Reeder, BJ | 1 |
| Hider, RC | 1 |
| Zhou, T | 1 |
| Mohammadpour, H | 2 |
| Majidzadeh-A, K | 1 |
| Fekrazad, R | 1 |
| Shimamura, Y | 1 |
| Tamatani, D | 1 |
| Kuniyasu, S | 1 |
| Mizuki, Y | 1 |
| Suzuki, T | 1 |
| Katsura, H | 1 |
| Yamada, H | 1 |
| Endo, Y | 1 |
| Osaki, T | 1 |
| Ishizuka, M | 1 |
| Tanaka, T | 1 |
| Yamanaka, N | 1 |
| Kurahashi, T | 1 |
| Uto, Y | 1 |
| Fahey, JM | 1 |
| Girotti, AW | 6 |
| Tsai, T | 1 |
| Ji, HT | 1 |
| Chiang, PC | 1 |
| Chou, RH | 1 |
| Chang, WS | 1 |
| Chen, CT | 1 |
| Bhowmick, R | 3 |
| Osiecka, B | 1 |
| Jurczyszyn, K | 1 |
| Symonowicz, K | 1 |
| Bronowicz, A | 1 |
| Ostasiewicz, P | 1 |
| Czapińska, E | 1 |
| Hotowy, K | 1 |
| Krzystek-Korpacka, M | 1 |
| Gebarowska, E | 1 |
| Izykowska, I | 1 |
| Dziegiel, P | 1 |
| Terlecki, G | 1 |
| Ziółkowski, P | 1 |
| Cogno, IS | 1 |
| Vittar, NB | 1 |
| Lamberti, MJ | 1 |
| Rivarola, VA | 1 |
| Feuerstein, T | 1 |
| Berkovitch-Luria, G | 1 |
| Nudelman, A | 1 |
| Rephaeli, A | 1 |
| Malik, Z | 1 |
| Ziegler, VG | 1 |
| Knaup, J | 1 |
| Stahl, D | 1 |
| Krammer, B | 1 |
| Plaetzer, K | 1 |
| Yoon, JH | 1 |
| Yoon, HE | 1 |
| Kim, O | 1 |
| Kim, SK | 1 |
| Ahn, SG | 1 |
| Kang, KW | 1 |
| Rogers, GS | 1 |
| Leman, JA | 1 |
| Dick, DC | 1 |
| Morton, CA | 1 |
| Kriska, T | 2 |
| Korytowski, W | 2 |
| Frei, KA | 1 |
| Bonel, HM | 1 |
| Frick, H | 1 |
| Walt, H | 3 |
| Steiner, RA | 2 |
| Kasili, PM | 1 |
| Song, JM | 1 |
| Vo-Dinh, T | 1 |
| Sabban, F | 1 |
| Collinet, P | 1 |
| Cosson, M | 1 |
| Mordon, S | 1 |
| Berger, Y | 1 |
| Chapuis Bernasconi, C | 1 |
| Schmitt, F | 1 |
| Neier, R | 1 |
| Juillerat-Jeanneret, L | 1 |
| Dorward, AM | 1 |
| Fancher, KS | 1 |
| Duffy, TM | 1 |
| Beamer, WG | 1 |
| Alvarez, MG | 1 |
| Lacelli, MS | 1 |
| Rivarola, V | 1 |
| Batlle, A | 1 |
| Fukuda, H | 1 |
| Ziegler, SA | 1 |
| Loucks, C | 1 |
| Madsen, SJ | 1 |
| Carper, SW | 1 |
| Cairnduff, F | 1 |
| Stringer, MR | 1 |
| Hudson, EJ | 1 |
| Ash, DV | 1 |
| Brown, SB | 1 |
| Fritsch, C | 1 |
| Becker-Wegerich, PM | 1 |
| Schulte, KW | 1 |
| Neuse, W | 1 |
| Lehmann, P | 1 |
| Ruzicka, T | 1 |
| Goerz, G | 1 |
| Calzavara-Pinton, PG | 1 |
| Szeimies, RM | 1 |
| Ortel, B | 1 |
| Zane, C | 1 |
| Hilf, R | 1 |
| Havens, JJ | 1 |
| Gibson, SL | 1 |
| Ladner, DP | 1 |
| Allemann, J | 1 |
| Haller, U | 1 |
| Yang, X | 1 |
| Wang, C | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| ALA-induced Fluorescence Imaging of Breast Cancers Using the Handheld PRODIGI and Eagle Imaging Devices[NCT01837225] | 90 participants (Anticipated) | Observational | 2010-09-30 | Recruiting | |||
| The Effect of 5-aminolaevulinic Acid Photodynamic Therapy Versus C02 Laser in the Treatment of Persistent Cervical Low-grade Squamous Intraepithelial Lesions With High-risk HPV Infection:A Non-randomized Controlled Trail Study[NCT06052033] | 40 participants (Anticipated) | Interventional | 2023-09-11 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
4 reviews available for aminolevulinic acid and Breast Neoplasms
| Article | Year |
|---|---|
Fluorescence Imaging of Breast Tumors and Gastrointestinal Cancer.
Topics: Aminolevulinic Acid; Barrett Esophagus; Breast Neoplasms; Female; Fluorescence; Gastrointestinal Neo | 2020 |
Topical 5-ALA photodynamic therapy for the treatment of cutaneous T-cell lymphoma.
Topics: Aminolevulinic Acid; Breast Neoplasms; Female; Humans; Lymphoma, T-Cell, Cutaneous; Middle Aged; Pho | 2002 |
[Fluorescence imaging technique: diagnostic and therapeutic interest in gynecology].
Topics: Aminolevulinic Acid; Breast Neoplasms; Female; Genital Diseases, Female; Gynecology; Humans; Neoplas | 2004 |
Photodynamic therapy with systemic administration of photosensitizers in dermatology.
Topics: Aminolevulinic Acid; Bowen's Disease; Breast Neoplasms; Dermatology; Dihematoporphyrin Ether; Female | 1996 |
3 trials available for aminolevulinic acid and Breast Neoplasms
| Article | Year |
|---|---|
Intraoperative fluorescence imaging with aminolevulinic acid detects grossly occult breast cancer: a phase II randomized controlled trial.
Topics: Adult; Aged; Aged, 80 and over; Aminolevulinic Acid; Biopsy; Breast Neoplasms; Contrast Media; Femal | 2021 |
Photodynamic detection of diseased axillary sentinel lymph node after oral application of aminolevulinic acid in patients with breast cancer.
Topics: Administration, Oral; Adult; Aminolevulinic Acid; Axilla; Breast Neoplasms; Female; Humans; Light; L | 2004 |
Superficial photodynamic therapy with topical 5-aminolaevulinic acid for superficial primary and secondary skin cancer.
Topics: Adenocarcinoma; Administration, Topical; Aminolevulinic Acid; Bowen's Disease; Breast Neoplasms; Car | 1994 |
42 other studies available for aminolevulinic acid and Breast Neoplasms
| Article | Year |
|---|---|
Vitamin D enhances the sensitivity of breast cancer cells to the combination therapy of photodynamic therapy and paclitaxel.
Topics: Aminolevulinic Acid; Apoptosis; bcl-2-Associated X Protein; Breast Neoplasms; Caspase 3; Cell Line, | 2022 |
Enlarging the Scope of 5-Aminolevulinic Acid-Mediated Photodiagnosis towards Breast Cancers.
Topics: Aminolevulinic Acid; Breast Neoplasms; Cell Line, Tumor; Female; Humans; MCF-7 Cells; Photochemother | 2022 |
Enlarging the Scope of 5-Aminolevulinic Acid-Mediated Photodiagnosis towards Breast Cancers.
Topics: Aminolevulinic Acid; Breast Neoplasms; Cell Line, Tumor; Female; Humans; MCF-7 Cells; Photochemother | 2022 |
Enlarging the Scope of 5-Aminolevulinic Acid-Mediated Photodiagnosis towards Breast Cancers.
Topics: Aminolevulinic Acid; Breast Neoplasms; Cell Line, Tumor; Female; Humans; MCF-7 Cells; Photochemother | 2022 |
Enlarging the Scope of 5-Aminolevulinic Acid-Mediated Photodiagnosis towards Breast Cancers.
Topics: Aminolevulinic Acid; Breast Neoplasms; Cell Line, Tumor; Female; Humans; MCF-7 Cells; Photochemother | 2022 |
Virtual-freezing fluorescence imaging flow cytometry with 5-aminolevulinic acid stimulation and antibody labeling for detecting all forms of circulating tumor cells.
Topics: Aminolevulinic Acid; Antibodies; Biomarkers, Tumor; Breast Neoplasms; Cell Line, Tumor; Epithelial C | 2023 |
Triphenylphosphonium conjugated gold nanotriangles impact Pi3K/AKT pathway in breast cancer cells: a photodynamic therapy approach.
Topics: Aminolevulinic Acid; Apoptosis; Breast Neoplasms; Cell Line, Tumor; Female; Gold; Humans; Metal Nano | 2023 |
Tumor cell death in orthotopic breast cancer model by NanoALA: a novel perspective on photodynamic therapy in oncology.
Topics: Aminolevulinic Acid; Animals; Breast Neoplasms; Cell Death; Cell Line, Tumor; Drug Carriers; Humans; | 2020 |
Investigation of LED-based photodynamic therapy efficiency on breast cancer cells.
Topics: Aminolevulinic Acid; Apoptosis; Breast Neoplasms; Cell Shape; Cell Survival; Female; Humans; MCF-7 C | 2021 |
Uptake of silver, gold, and hybrids silver-iron, gold-iron and silver-gold aminolevulinic acid nanoparticles by MCF-7 breast cancer cells.
Topics: Aminolevulinic Acid; Breast Neoplasms; Cell Line, Tumor; Gold; Humans; Iron; MCF-7 Cells; Metal Nano | 2020 |
5-Aminolevulinic acid induced photodynamic therapy (ALA-PDT) for erosive adenomatosis of the nipple: A case report.
Topics: Adenoma; Adult; Aminolevulinic Acid; Breast Neoplasms; Female; Humans; Nipples; Papilloma; Photochem | 2021 |
Adjuvant Photodynamic Therapy, Mediated via Topical Versus Systemic Administration of 5-Aminolevulinic Acid for Control of Murine Mammary Tumor after Surgical Resection.
Topics: Administration, Topical; Aminolevulinic Acid; Animals; Breast Neoplasms; Female; Humans; Mice; Photo | 2022 |
Photodynamic therapy using 5-aminolevulinic acid triggered DNA damage of adenocarcinoma breast cancer and hepatocellular carcinoma cell lines.
Topics: Adenocarcinoma; Aminolevulinic Acid; Breast Neoplasms; Carcinoma, Hepatocellular; DNA Damage; Hep G2 | 2018 |
Radiotherapy-induced morphoea of the breast responding to photodynamic therapy.
Topics: Aged; Aminolevulinic Acid; Breast Neoplasms; Carcinoma; Female; Humans; Photochemotherapy; Photosens | 2018 |
Sequentially self-assembled polysaccharide-based nanocomplexes for combined chemotherapy and photodynamic therapy of breast cancer.
Topics: Aminolevulinic Acid; Animals; Antineoplastic Agents; Apoptosis; Breast Neoplasms; Chitosan; Doxorubi | 2019 |
Metabolic reprogramming by Dichloroacetic acid potentiates photodynamic therapy of human breast adenocarcinoma MCF-7 cells.
Topics: Adenocarcinoma; Aminolevulinic Acid; Apoptosis; Breast Neoplasms; Cell Survival; Dichloroacetic Acid | 2018 |
Ferrochelatase Deficiency Abrogated the Enhancement of Aminolevulinic Acid-mediated Protoporphyrin IX by Iron Chelator Deferoxamine.
Topics: Aminolevulinic Acid; Breast Neoplasms; Cell Line, Tumor; Deferoxamine; Epithelial Cells; Female; Fer | 2019 |
Fluorescence-based discrimination of breast cancer cells by direct exposure to 5-aminolevulinic acid.
Topics: Aminolevulinic Acid; Animals; Biopsy, Fine-Needle; Breast Neoplasms; Cell Line, Tumor; Diketopiperaz | 2019 |
Synergistic apoptotic effect of Doxil ® and aminolevulinic acid-based photodynamic therapy on human breast adenocarcinoma cells.
Topics: Adenocarcinoma; Aminolevulinic Acid; Antibiotics, Antineoplastic; Apoptosis; Breast Neoplasms; Cell | 2014 |
Design, synthesis and biological evaluation of 5-aminolaevulinic acid/3-hydroxypyridinone conjugates as potential photodynamic therapeutical agents.
Topics: Aminolevulinic Acid; Breast Neoplasms; Cell Line, Tumor; Cell Survival; Drug Design; Female; Humans; | 2015 |
Antitumor effect of conditioned media derived from murine MSCs and 5-aminolevulinic acid (5-ALA) mediated photodynamic therapy in breast cancer in vitro.
Topics: Adaptor Proteins, Signal Transducing; Aminolevulinic Acid; Animals; Apoptosis; Breast Neoplasms; Cel | 2015 |
Antitumor effect of combined Dkk-3 and 5-ALA mediated photodynamic therapy in breast cancer cell's colony.
Topics: Adaptor Proteins, Signal Transducing; Aminolevulinic Acid; Animals; Antineoplastic Agents; Apoptosis | 2016 |
5-Aminolevulinic Acid Enhances Ultrasound-mediated Antitumor Activity via Mitochondrial Oxidative Damage in Breast Cancer.
Topics: Aminolevulinic Acid; Animals; Antineoplastic Agents; Apoptosis; Breast Neoplasms; Cell Line, Tumor; | 2016 |
Nitric oxide-mediated resistance to photodynamic therapy in a human breast tumor xenograft model: Improved outcome with NOS2 inhibitors.
Topics: Amidines; Aminolevulinic Acid; Animals; Apoptosis; Apoptosis Regulatory Proteins; Benzoates; Benzyla | 2017 |
ALA-PDT results in phenotypic changes and decreased cellular invasion in surviving cancer cells.
Topics: Adenocarcinoma; Aminolevulinic Acid; Breast Neoplasms; Cell Line, Tumor; Cell Movement; Down-Regulat | 2009 |
Signaling events in apoptotic photokilling of 5-aminolevulinic acid-treated tumor cells: inhibitory effects of nitric oxide.
Topics: Aminolevulinic Acid; Apoptosis; Apoptosis Regulatory Proteins; Blotting, Western; Breast Neoplasms; | 2009 |
Cytoprotective induction of nitric oxide synthase in a cellular model of 5-aminolevulinic acid-based photodynamic therapy.
Topics: Adenocarcinoma; Aminolevulinic Acid; Apoptosis; Breast Neoplasms; Caspases; Cell Line, Tumor; Cytopr | 2010 |
In vitro and in vivo matrix metalloproteinase expression after photodynamic therapy with a liposomal formulation of aminolevulinic acid and its methyl ester.
Topics: Aminolevulinic Acid; Animals; Breast Neoplasms; Cell Line, Tumor; Cell Survival; Female; Humans; Iso | 2010 |
Optimization of photodynamic therapy response by survivin gene knockdown in human metastatic breast cancer T47D cells.
Topics: Aminolevulinic Acid; Apoptosis; bcl-2 Homologous Antagonist-Killer Protein; Breast Neoplasms; Caspas | 2011 |
Modulating ALA-PDT efficacy of mutlidrug resistant MCF-7 breast cancer cells using ALA prodrug.
Topics: Aminolevulinic Acid; Breast Neoplasms; Cell Line, Tumor; Doxorubicin; Drug Resistance, Multiple; Dru | 2011 |
Fluorescence detection and depletion of T47D breast cancer cells from human mononuclear cell-enriched blood preparations by photodynamic treatment: Basic in vitro experiments towards the removal of circulating tumor cells.
Topics: Adenocarcinoma; Aminolevulinic Acid; Animals; Breast Neoplasms; Cell Line; Cell Line, Tumor; Endothe | 2011 |
The enhanced anti-cancer effect of hexenyl ester of 5-aminolaevulinic acid photodynamic therapy in adriamycin-resistant compared to non-resistant breast cancer cells.
Topics: Aminolevulinic Acid; Apoptosis; Breast Neoplasms; Doxorubicin; Drug Resistance, Neoplasm; Female; He | 2012 |
Continuous low-irradiance photodynamic therapy: a new therapeutic paradigm.
Topics: Aminolevulinic Acid; Animals; Breast Neoplasms; Dihematoporphyrin Ether; Dose-Response Relationship, | 2012 |
Cytoprotective signaling associated with nitric oxide upregulation in tumor cells subjected to photodynamic therapy-like oxidative stress.
Topics: Adenocarcinoma; Aminolevulinic Acid; Apoptosis; Apoptosis Regulatory Proteins; Breast Neoplasms; Cel | 2013 |
Hyperresistance to photosensitized lipid peroxidation and apoptotic killing in 5-aminolevulinate-treated tumor cells overexpressing mitochondrial GPX4.
Topics: Aminolevulinic Acid; Apoptosis; Breast Neoplasms; Cell Survival; Flow Cytometry; Free Radicals; Glut | 2002 |
Optical sensor for the detection of caspase-9 activity in a single cell.
Topics: Aminolevulinic Acid; Apoptosis; Biosensing Techniques; Breast Neoplasms; Caspase 9; Caspases; Cell L | 2004 |
Role of mitochondrial cardiolipin peroxidation in apoptotic photokilling of 5-aminolevulinate-treated tumor cells.
Topics: Aminolevulinic Acid; Apoptosis; Blotting, Western; Breast Neoplasms; Cardiolipins; Caspases; Cell Li | 2005 |
Determination of intracellular prolyl/glycyl proteases in intact living human cells and protoporphyrin IX production as a reporter system.
Topics: Adenosine Deaminase; Aminolevulinic Acid; Breast Neoplasms; Cell Line, Tumor; Colonic Neoplasms; Cys | 2005 |
Early neoplastic and metastatic mammary tumours of transgenic mice detected by 5-aminolevulinic acid-stimulated protoporphyrin IX accumulation.
Topics: Aminolevulinic Acid; Animals; Breast Neoplasms; Mice; Mice, Transgenic; Neoplasm Metastasis; Protopo | 2005 |
5-aminolevulinic acid-mediated photodynamic therapy on Hep-2 and MCF-7c3 cells.
Topics: Adenocarcinoma; Aminolevulinic Acid; Apoptosis; Breast Neoplasms; Cell Line, Tumor; Cell Survival; D | 2007 |
Heat shock protein 27 protects against aminolevulinic acid-mediated photodynamic therapy-induced apoptosis and necrosis in human breast cancer cells.
Topics: Aminolevulinic Acid; Apoptosis; Breast Neoplasms; Cell Survival; Dose-Response Relationship, Radiati | 2007 |
[Photodynamic therapy and breast-plasty of a extensive superficial trunk skin basalioma of the breast. An effective combination therapy with photodynamic diagnosis].
Topics: Administration, Topical; Aminolevulinic Acid; Breast Neoplasms; Carcinoma, Basal Cell; Combined Moda | 1996 |
Effect of delta-aminolevulinic acid on protoporphyrin IX accumulation in tumor cells transfected with plasmids containing porphobilinogen deaminase DNA.
Topics: Aminolevulinic Acid; Breast Neoplasms; DNA; Gene Expression Regulation, Neoplastic; Humans; Hydroxym | 1999 |
Photodynamic diagnosis of breast tumours after oral application of aminolevulinic acid.
Topics: Administration, Oral; Aminolevulinic Acid; Axilla; Breast Neoplasms; Feasibility Studies; Female; Hu | 2001 |
Her2 oncogene transformation enhances 5-aminolevulinic acid-mediated protoporphyrin IX production and photodynamic therapy response.
Topics: Aminolevulinic Acid; Breast Neoplasms; Cell Line, Tumor; Cell Survival; Cell Transformation, Neoplas | 2016 |