Page last updated: 2024-10-16

aminolevulinic acid and Alopecia Circumscripta

aminolevulinic acid has been researched along with Alopecia Circumscripta in 8 studies

Aminolevulinic Acid: A compound produced from succinyl-CoA and GLYCINE as an intermediate in heme synthesis. It is used as a PHOTOCHEMOTHERAPY for actinic KERATOSIS.
5-aminolevulinic acid : The simplest delta-amino acid in which the hydrogens at the gamma position are replaced by an oxo group. It is metabolised to protoporphyrin IX, a photoactive compound which accumulates in the skin. Used (in the form of the hydrochloride salt)in combination with blue light illumination for the treatment of minimally to moderately thick actinic keratosis of the face or scalp.

Research Excerpts

ExcerptRelevanceReference
"Photodynamic therapy (PDT) with aminolevulinic acid or methyl 5-aminolevulinic acid (MAL) has been tried for the treatment of alopecia areata (AA)."3.76Photodynamic therapy with methyl 5-aminolevulinate acid might be ineffective in recalcitrant alopecia totalis regardless of using a microneedle roller to increase skin penetration. ( Kim, BJ; Kim, MN; Lee, JW; Li, K; Yoo, KH, 2010)
" The main adverse effects in ALA-PDT treatment were mild edema and tolerable pain, and no adverse effect was observed in red-light treatment."3.01Treatment of androgenetic alopecia with 5-aminolevulinic acid photodynamic therapy: A randomized, placebo-controlled, split-scalp study of efficacy and safety. ( Cao, Z; Hu, W; Liu, X; Wang, P; Wang, X; Zhang, G; Zhang, L; Zhang, Y; Zhou, Z, 2021)
" The adverse effects of ALA-PDT were mild, which indicated safety and tolerability of this treatment."3.01Treatment of androgenetic alopecia with 5-aminolevulinic acid photodynamic therapy: A randomized, placebo-controlled, split-scalp study of efficacy and safety. ( Cao, Z; Hu, W; Liu, X; Wang, P; Wang, X; Zhang, G; Zhang, L; Zhang, Y; Zhou, Z, 2021)

Research

Studies (8)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's2 (25.00)29.6817
2010's3 (37.50)24.3611
2020's3 (37.50)2.80

Authors

AuthorsStudies
Linares-González, L1
Ródenas-Herranz, T1
Sáenz-Guirado, S1
Ruiz-Villaverde, R1
Cao, Z1
Liu, X1
Zhang, L1
Zhang, Y1
Zhou, Z1
Zhang, G1
Wang, P1
Hu, W1
Wang, X1
Giuffrida, R1
Borgia, F1
Marafioti, I1
Riso, G1
Cannavò, SP1
Lee, JW2
Yoo, KH2
Kim, BJ2
Kim, MN2
Li, K1
Fernández-Guarino, M1
Harto, A1
García-Morales, I1
Pérez-García, B1
Arrazola, JM1
Jaén, P1
Bissonnette, R1
Shapiro, J1
Zeng, H1
McLean, DI1
Lui, H1
Giorgio, CM1
Babino, G1
Caccavale, S1
Russo, T1
De Rosa, AB1
Alfano, R1
Fulgione, E1
Argenziano, G1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Efficacy of Hair Transplantation Compared With Hypodermic Needle Irritation in Alopecia Areata[NCT01385839]4 participants (Actual)Interventional2009-10-31Terminated (stopped due to low enrollment)
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trials

2 trials available for aminolevulinic acid and Alopecia Circumscripta

ArticleYear
Treatment of androgenetic alopecia with 5-aminolevulinic acid photodynamic therapy: A randomized, placebo-controlled, split-scalp study of efficacy and safety.
    Photodiagnosis and photodynamic therapy, 2021, Volume: 36

    Topics: Alopecia Areata; Aminolevulinic Acid; Humans; Photochemotherapy; Photosensitizing Agents; Scalp; Tre

2021
Topical photodynamic therapy with 5-aminolaevulinic acid does not induce hair regrowth in patients with extensive alopecia areata.
    The British journal of dermatology, 2000, Volume: 143, Issue:5

    Topics: Adult; Alopecia Areata; Aminolevulinic Acid; Dose-Response Relationship, Drug; Female; Hair; Humans;

2000

Other Studies

6 other studies available for aminolevulinic acid and Alopecia Circumscripta

ArticleYear
Successful response to photodynamic therapy with 5-aminolevulinic acid nanoemulsified gel in a patient with universal alopecia areata refractory to conventional treatment.
    Dermatologic therapy, 2020, Volume: 33, Issue:3

    Topics: Alopecia Areata; Aminolevulinic Acid; Humans; Photochemotherapy

2020
Combination of tacalcitol ointment and photodynamic therapy for the treatment of follicular mucinosis of the scalp.
    Photodiagnosis and photodynamic therapy, 2019, Volume: 27

    Topics: Alopecia Areata; Aminolevulinic Acid; Dermatologic Agents; Dihydroxycholecalciferols; Drug Therapy,

2019
Photodynamic therapy with methyl 5-aminolevulinate acid combined with microneedle treatment in patients with extensive alopecia areata.
    Clinical and experimental dermatology, 2010, Volume: 35, Issue:5

    Topics: Adult; Alopecia Areata; Aminolevulinic Acid; Female; Humans; Injections, Intradermal; Male; Needles;

2010
Photodynamic therapy with methyl 5-aminolevulinate acid might be ineffective in recalcitrant alopecia totalis regardless of using a microneedle roller to increase skin penetration.
    Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.], 2010, Volume: 36, Issue:5

    Topics: Adult; Alopecia Areata; Aminolevulinic Acid; Biopsy; Drug Delivery Systems; Equipment Design; Female

2010
Failure to treat alopecia areata with photodynamic therapy.
    Clinical and experimental dermatology, 2008, Volume: 33, Issue:5

    Topics: Adult; Aged; Alopecia Areata; Aminolevulinic Acid; Face; Female; Hair; Humans; Male; Middle Aged; Ph

2008
Combination of photodynamic therapy with 5-aminolaevulinic acid and microneedling in the treatment of alopecia areata resistant to conventional therapies: our experience with 41 patients.
    Clinical and experimental dermatology, 2020, Volume: 45, Issue:3

    Topics: Adult; Alopecia Areata; Aminolevulinic Acid; Combined Modality Therapy; Dry Needling; Female; Humans

2020