aminolevulinic acid and Acne studies

Aminolevulinic Acid: A compound produced from succinyl-CoA and GLYCINE as an intermediate in heme synthesis. It is used as a PHOTOCHEMOTHERAPY for actinic KERATOSIS.
5-aminolevulinic acid : The simplest delta-amino acid in which the hydrogens at the gamma position are replaced by an oxo group. It is metabolised to protoporphyrin IX, a photoactive compound which accumulates in the skin. Used (in the form of the hydrochloride salt)in combination with blue light illumination for the treatment of minimally to moderately thick actinic keratosis of the face or scalp.

Research Excerpts

Excerpt	Relevance	Reference
"Modified 5-aminolevulinic acid photodynamic therapy (M-PDT) and isotretinoin (ISO) are effective treatments for moderate to severe acne vulgaris."	9.69	Modified red light 5-aminolevulinic acid photodynamic therapy versus low-dose isotretinoin therapy for moderate to severe acne vulgaris: A prospective, randomized, multicenter study. ( Ju, Q; Liu, J; Liu, X; Lv, T; Shi, L; Wang, B; Wang, P; Wang, R; Wang, X; Wei, Z; Wong, H; Wu, Y; Yang, J; Yang, Y; Zhang, L; Zhao, Y, 2023)
"To evaluate the efficacy of a new three-step irradiance schedule derived from the psychological "peak-end rule" and two-step irradiance schedule in relieving pain during 5-aminolevulinic acid PDT (ALA-PDT) on acne."	9.51	Three-step irradiance schedule versus two-step irradiance schedule for pain control during topical 5-aminolevulinic acid-photodynamic therapy of facial acne in Chinese patients: A prospective randomized comparative study. ( Cui, L; Liu, YB; Sun, XD; Wu, HE; Xu, GJ, 2022)
"PDT combined with isotretinoin has higher effective rate and lower recurrence rate than single PDT, and is a choice for the treatment of moderate to severe acne."	9.41	Combination of 5-Aminolevulinic acid photodynamic therapy and isotretinoin to treat moderate-to-severe acne. ( Liu, L; Liu, P; Meng, L; Wei, G; Zhang, C, 2021)
"To evaluate the efficacy and safety of PDT combined with isotretinoin in the treatment of moderate to severe acne."	9.41	Combination of 5-Aminolevulinic acid photodynamic therapy and isotretinoin to treat moderate-to-severe acne. ( Liu, L; Liu, P; Meng, L; Wei, G; Zhang, C, 2021)
"We investigated the effects of a cleanser with 5-aminolevulinic acid and peptides on mild to moderate acne vulgaris."	9.34	Randomized controlled double-blind study of a cleanser composed of 5-aminolevulinic acid and peptides on mild and moderate acne vulgaris. ( Kim, JY; Lee, HJ; Lee, WJ; Park, KD, 2020)
"We think the cleanser with 5-aminolevulinic acid and peptides is a useful and safe therapeutic agent for mild to moderate acne vulgaris."	9.34	Randomized controlled double-blind study of a cleanser composed of 5-aminolevulinic acid and peptides on mild and moderate acne vulgaris. ( Kim, JY; Lee, HJ; Lee, WJ; Park, KD, 2020)
"Photodynamic therapy (PDT) with 5-aminolevulinic acid (ALA) has been described as an effective treatment for severe acne."	9.34	Photodynamic therapy for severe facial acne vulgaris with 5% 5-aminolevulinic acid vs 10% 5-aminolevulinic acid: A split-face randomized controlled study. ( He, Y; Huang, H; Huang, J; Lu, C; Wu, X; Zhang, J; Zhang, X, 2020)
"ALA-PDT offers promise as an alternative treatment for moderately severe inflammatory acne that has a higher effectiveness than the combination of doxycycline and adapalene gel in reducing noninflammatory and total lesions at 6 weeks."	9.30	Comparison of efficacy of aminolaevulinic acid photodynamic therapy vs. adapalene gel plus oral doxycycline for treatment of moderate acne vulgaris-A simple, blind, randomized, and controlled trial. ( Cárdenas, C; Hasson, A; Nicklas, C; Rubio, R, 2019)
"To investigate the effect of 5-aminolevulinic acid photodynamic therapy (ALA-PDT) on the expression of Toll like receptors (TLRs) in human keratinocytes and its role in acne treatment."	9.22	Effects of 5-aminolevulinic acid photodynamic therapy on TLRs in acne lesions and keratinocytes co-cultured with P. acnes. ( Chen, Q; Huang, Z; Liu, Y; Ma, Y; Wang, Q; Xiang, L, 2016)
"To investigate the efficacy and safety of low-concentration 5-aminolevulinic acid photodynamic therapy (ALA-PDT) in the treatment of different severity of acne vulgaris and optimize the treatment regimen."	9.17	Low-dose topical 5-aminolevulinic acid photodynamic therapy in the treatment of different severity of acne vulgaris. ( Chen, L; Lai, W; Li, HZ; Li, YH; Lin, T; Liu, YB; Ma, L; Tan, ZJ; Tian, HQ; Wang, WZ; Wang, XL; Wu, Y; Xiang, LH; Yang, HL; Yin, R; Yu, B, 2013)
"Photodynamic therapy using topical 5-aminolevulinic acid (ALA) has been successful in treating acne vulgaris, but sun avoidance for at least 48 hours after treatment is necessary due to the risk of post-treatment photosensitivity."	9.15	0.5% Liposome-encapsulated 5-aminolevulinic acid (ALA) photodynamic therapy for acne treatment. ( An, JS; Chang, SE; Cho, S; Choi, JH; Choi, WW; Kang, SM; Kim, BY; Kim, JE; Kwon, IH; Lee, DH; Lee, MW; Moon, KC; Won, CH, 2011)
"We sought to examine the efficacy of PDT using 5-aminolevulinic acid (ALA) and pulsed dye laser therapy in the treatment of acne."	9.14	Photodynamic therapy for acne vulgaris: a randomized, controlled, split-face clinical trial of topical aminolevulinic acid and pulsed dye laser therapy. ( Bailey, E; Hamilton, T; Kang, S; Orringer, JS; Sachs, DL; Voorhees, JJ, 2010)
"Photodynamic therapy (PDT) with topical 5-aminolevulinic acid (ALA) is used for effective treatment of facial acne vulgaris."	9.14	A comparative study of topical 5-aminolevulinic acid incubation times in photodynamic therapy with intense pulsed light for the treatment of inflammatory acne. ( Han, EC; Lee, JH; Lee, KH; Oh, SH; Ryu, DJ, 2009)
"Intractable acne on the body was clinically treated with photodynamic therapy (PDT) combining oral administration of delta-aminolevulinic acid (ALA) with polychromatic visible light from a metal halide lamp."	9.11	Delta-aminolevulinic acid-based photodynamic therapy for acne on the body. ( Itoh, Y; Kawashima, N; Kimura, M; Tokuoka, Y, 2004)
"We report the case of a 20-year-old man with acne conglobata (AC) who was treated with 5-aminolevulinic acid photodynamic therapy (ALA-PDT) sequentially to deroofing, and finally used fractional carbon dioxide laser for esthetic requirements, achieving satisfying results."	8.12	A case of 5-aminolevulinic acid photodynamic therapy(ALA-PDT)combined with surgery for the treatment of acne conglobata. ( Bu, WB; Fang, F; Wu, QY; Zhang, Q, 2022)
"To study the clinical efficacy, recurrence rate and safety of 5-aminolevulinic acid-based photodynamic therapy (ALA-PDT) combined with microneedle or CO2 lattice laser (CO2FL), in comparison with intrascar betamethasone injection in the treatment of hypertrophic acne scar."	8.12	A clinical study of carbon dioxide lattice laser-assisted or microneedle-assisted 5-aminolevulinic acid-based photodynamic therapy for the treatment of hypertrophic acne scars. ( Huang, F; Li, C; Li, X; Tian, Y; Xia, A; Yan, D; Yun, Q; Zhang, J; Zhang, S; Zhao, H, 2022)
"Aminolevulinic acid-photodynamic therapy (ALA-PDT) has been an effective treatment for moderate to severe acne."	8.02	Modulation of skin microbiome in acne patients by aminolevulinic acid-photodynamic therapy. ( Ge, Y; Tao, S; Yang, Y; Zeng, R; Zheng, H, 2021)
"6 % topical aminolevulinic acid (ALA) and a short incubation time with red light in moderate to severe acne."	7.81	Low-Dose Topical 5-Aminolevulinic Acid Photodynamic Therapy in the Treatment of Different Severity of Acne Vulgaris. ( Cao, L; Fan, H; Fan, Y; Jing, C; Li, F; Sun, H; Tao, SQ; Xia, RS; Yang, LJ, 2015)
"Propionibacterium acnes naturally produces endogenous porphyrins that are composed of coproporphyrin III (CPIII) and protoporphyrin IX (PpIX)."	7.77	Comparative study of the bactericidal effects of 5-aminolevulinic acid with blue and red light on Propionibacterium acnes. ( Beom, HJ; Choi, MS; Lee, JB; Park, HR; Yun, SJ, 2011)
"The use of photodynamic therapy (PDT) with 20% 5-aminolevulinic acid (ALA) for the treatment of acne vulgaris has been explored."	7.74	Treatment of moderate to severe inflammatory acne vulgaris: photodynamic therapy with 5-aminolevulinic acid and a novel advanced fluorescence technology pulsed light source. ( Biron, JA; Boring, M; Bradshaw, VL; Bridges, TM; Gold, MH, 2007)
"Eight patients with mild-to-moderate acne vulgaris on the face were treated with one session of topical aminolevulinic acid (ALA)-PDT using a red light."	7.73	Topical aminolevulinic acid-photodynamic therapy for the treatment of acne vulgaris. ( Hong, SB; Lee, MH, 2005)
"Photodynamic therapy (PDT) with topical 5-aminolevulinic acid (ALA) and red light (550-700 nm) has been introduced for effective treatment of facial acne."	7.73	Treatment of inflammatory facial acne vulgaris with intense pulsed light and short contact of topical 5-aminolevulinic acid: a pilot study. ( Choawawanich, P; Rojanamatin, J, 2006)
"Existing treatments of acne vulgaris may be complicated or elicit undesirable side effects."	6.94	Randomized controlled double-blind study of a cleanser composed of 5-aminolevulinic acid and peptides on mild and moderate acne vulgaris. ( Kim, JY; Lee, HJ; Lee, WJ; Park, KD, 2020)
"Acne vulgaris is a chronic inflammatory skin disease, commonly treated with topical or systemic drugs, according to the severity of the condition."	6.90	The efficacy and tolerability of 5-aminolevulinic acid 5% thermosetting gel photodynamic therapy (PDT) in the treatment of mild-to-moderate acne vulgaris. A two-center, prospective assessor-blinded, proof-of-concept study. ( Bianchi, L; Campione, E; Cannizzaro, MV; Dattola, A; Del Duca, E; Garofalo, V; Milani, M; Serini, SM; Ventura, A, 2019)
"Acne vulgaris is one of the most common dermatological problems, and its therapeutic options include topical and systemic retinoids and antibiotics."	6.87	Comparative study of the bactericidal effects of indocyanine green- and methyl aminolevulinate-based photodynamic therapy on Propionibacterium acnes as a new treatment for acne. ( Choi, SH; Kim, KH; Seo, JW, 2018)
"P."	6.87	Comparative study of the bactericidal effects of indocyanine green- and methyl aminolevulinate-based photodynamic therapy on Propionibacterium acnes as a new treatment for acne. ( Choi, SH; Kim, KH; Seo, JW, 2018)
"The success rates of conventional treatments to acne vulgaris are limited because of intolerance and resistance."	6.78	Effectiveness of photodynamic therapy with topical 5-aminolevulinic acid and intense pulsed light in Chinese acne vulgaris patients. ( Mei, X; Piao, Y; Shi, W, 2013)
"5% liposomal spray and IPL in combination with topical peeling agents is safe and efficacious, even in patients with acne recalcitrant to standard therapy."	6.75	Photodynamic therapy of acne vulgaris using 5-aminolevulinic acid 0.5% liposomal spray and intense pulsed light in combination with topical keratolytic agents. ( Bjerring, P; de Leeuw, J; Neumann, HA; van der Beek, N, 2010)
"5% in liposomal spray and intense pulsed light (IPL) in combination with topical peeling agents (Li-PDT-PC) in acne vulgaris."	6.75	Photodynamic therapy of acne vulgaris using 5-aminolevulinic acid 0.5% liposomal spray and intense pulsed light in combination with topical keratolytic agents. ( Bjerring, P; de Leeuw, J; Neumann, HA; van der Beek, N, 2010)
"Acne vulgaris is a common skin disease caused by multifactorial reasons involving excessive sebum secretion and inflammation by Cutibacterium acnes (C."	5.91	Topical methylene blue nanoformulation for the photodynamic therapy of acne vulgaris. ( Bang, J; Han, S; Kim, BR; Kim, S; Lee, YD; Shin, JW; Yang, JK, 2023)
"Conventional 5-aminolevulinic acid-photodynamic (ALA-PDT) therapy (10-20%) has been widely applied for moderate-to-severe acne."	5.69	The quantitative analysis of low-concentration (2%) ALA-PDT assisted with Q-switch 1064-nm Nd:YAG laser for acne vulgaris treatment. ( Chang, CC; Chen, YT; Chiang, HM; Huang, YH; Lin, BS; Lin, YJ; Liu, PH; Lu, ME; Shen, JW, 2023)
"Acne vulgaris is a chronic inflammatory disease that frequently occurs in adolescence."	5.62	Daylight photodynamic therapy with 5-aminolevulinic acid 5% gel for the treatment of mild-to-moderate inflammatory acne. ( Bennardo, L; Cannarozzo, G; Chester, J; Del Duca, E; Farnetani, F; Manfredini, M; Nisticò, SP; Pellacani, G; Petrini, N; Sannino, M; Schipani, G; Tamburi, F, 2021)
"To evaluate the efficacy of a new three-step irradiance schedule derived from the psychological "peak-end rule" and two-step irradiance schedule in relieving pain during 5-aminolevulinic acid PDT (ALA-PDT) on acne."	5.51	Three-step irradiance schedule versus two-step irradiance schedule for pain control during topical 5-aminolevulinic acid-photodynamic therapy of facial acne in Chinese patients: A prospective randomized comparative study. ( Cui, L; Liu, YB; Sun, XD; Wu, HE; Xu, GJ, 2022)
"Acne vulgaris is one of the most common skin diseases in adolescents."	5.42	Prospective study of topical 5-aminolevulinic acid photodynamic therapy for the treatment of severe adolescent acne in Chinese patients. ( Liu, Y; Ma, Y; Ren, J; Wang, Q; Xiang, L, 2015)
"PDT combined with isotretinoin has higher effective rate and lower recurrence rate than single PDT, and is a choice for the treatment of moderate to severe acne."	5.41	Combination of 5-Aminolevulinic acid photodynamic therapy and isotretinoin to treat moderate-to-severe acne. ( Liu, L; Liu, P; Meng, L; Wei, G; Zhang, C, 2021)
"To evaluate the efficacy and safety of PDT combined with isotretinoin in the treatment of moderate to severe acne."	5.41	Combination of 5-Aminolevulinic acid photodynamic therapy and isotretinoin to treat moderate-to-severe acne. ( Liu, L; Liu, P; Meng, L; Wei, G; Zhang, C, 2021)
"acnes."	5.37	Comparative study of the bactericidal effects of 5-aminolevulinic acid with blue and red light on Propionibacterium acnes. ( Beom, HJ; Choi, MS; Lee, JB; Park, HR; Yun, SJ, 2011)
"Photodynamic therapy (PDT) with 5-aminolevulinic acid (ALA) has been described as an effective treatment for severe acne."	5.34	Photodynamic therapy for severe facial acne vulgaris with 5% 5-aminolevulinic acid vs 10% 5-aminolevulinic acid: A split-face randomized controlled study. ( He, Y; Huang, H; Huang, J; Lu, C; Wu, X; Zhang, J; Zhang, X, 2020)
"ALA-PDT offers promise as an alternative treatment for moderately severe inflammatory acne that has a higher effectiveness than the combination of doxycycline and adapalene gel in reducing noninflammatory and total lesions at 6 weeks."	5.30	Comparison of efficacy of aminolaevulinic acid photodynamic therapy vs. adapalene gel plus oral doxycycline for treatment of moderate acne vulgaris-A simple, blind, randomized, and controlled trial. ( Cárdenas, C; Hasson, A; Nicklas, C; Rubio, R, 2019)
"To investigate the effect of 5-aminolevulinic acid photodynamic therapy (ALA-PDT) on the expression of Toll like receptors (TLRs) in human keratinocytes and its role in acne treatment."	5.22	Effects of 5-aminolevulinic acid photodynamic therapy on TLRs in acne lesions and keratinocytes co-cultured with P. acnes. ( Chen, Q; Huang, Z; Liu, Y; Ma, Y; Wang, Q; Xiang, L, 2016)
"To treat moderate to severe acne vulgaris, we developed an optical fiber imported intra-tissue photodynamic therapy: the optical fiber irradiation 5-aminolevulinic acid photodynamic therapy (OFI-ALA-PDT)."	5.22	Use of Optical Fiber Imported Intra-Tissue Photodynamic Therapy for Treatment of Moderate to Severe Acne Vulgaris. ( Chen, J; Cheng, S; Duan, X; Li, F; Lin, X; Liu, W; Wang, Q; Yuan, D, 2016)
"Photodynamic therapy using topical 5-aminolevulinic acid (ALA) has been successful in treating acne vulgaris, but sun avoidance for at least 48 hours after treatment is necessary due to the risk of post-treatment photosensitivity."	5.15	0.5% Liposome-encapsulated 5-aminolevulinic acid (ALA) photodynamic therapy for acne treatment. ( An, JS; Chang, SE; Cho, S; Choi, JH; Choi, WW; Kang, SM; Kim, BY; Kim, JE; Kwon, IH; Lee, DH; Lee, MW; Moon, KC; Won, CH, 2011)
"To evaluate the effectiveness of topical 5-aminolevulinic acid (ALA)-medicated photodynamic therapy (PDT) for the treatment of severe acne vulgaris."	5.14	Topical ALA PDT for the treatment of severe acne vulgaris. ( Guo, MX; Huang, Z; Wang, HW; Wang, XL; Zhang, LL, 2010)
"Photodynamic therapy (PDT) with aminolevulinic acid (ALA) has been shown to be an effective treatment for acne."	5.14	The effect of aminolevulinic acid photodynamic therapy on microcomedones and macrocomedones. ( Cacciapuoti, S; De Vita, V; Fabbrocini, G; Fardella, N; Monfrecola, G; Pastore, F, 2009)
"Photodynamic therapy (PDT) with topical 5-aminolevulinic acid (ALA) is used for effective treatment of facial acne vulgaris."	5.14	A comparative study of topical 5-aminolevulinic acid incubation times in photodynamic therapy with intense pulsed light for the treatment of inflammatory acne. ( Han, EC; Lee, JH; Lee, KH; Oh, SH; Ryu, DJ, 2009)
"An alternative approach in the treatment of acne vulgaris is photodynamic therapy (PDT) that uses light and aminolevulinic acid (ALA)-induced protoporphyrin IX (PpIX) production to eradicate Propionibacterium acnes found in acne lesions."	5.14	Radiant near infrared light emitting Diode exposure as skin preparation to enhance photodynamic therapy inflammatory type acne treatment outcome. ( Barolet, D; Boucher, A, 2010)
"To evaluate the efficacy and safety of LPDL alone versus LPDL in photodynamic therapy with methylaminolevulinic acid (MAL-LPDL) for acne vulgaris."	5.13	Long-pulsed dye laser versus long-pulsed dye laser-assisted photodynamic therapy for acne vulgaris: A randomized controlled trial. ( Haedersdal, M; Togsverd-Bo, K; Wiegell, SR; Wulf, HC, 2008)
"To determine the safety and efficacy of combination PDT with topical 5-aminolevulinic acid (ALA) and activation by long-pulsed, pulsed dye laser (LP PDL, 595 nm) energy with topical therapy in patients with mild to severe acne."	5.12	Long-pulsed dye laser-mediated photodynamic therapy combined with topical therapy for mild to severe comedonal, inflammatory, or cystic acne. ( Alexiades-Armenakas, M, 2006)
"Topical 5-aminolevulinic acid (ALA) and various light sources have been used to treat actinic keratoses and acne."	5.12	Efficacy of microdermabrasion preceding ALA application in reducing the incubation time of ALA in laser PDT. ( Frew, KE; George, D; Katz, BE; Maiwald, DC; Truong, S, 2007)
"Photodynamic therapy (PDT) with 5-aminolevulinic acid (ALA) is an emerging modality for the treatment of acne vulgaris."	5.12	A comparison of intense pulsed light, combination radiofrequency and intense pulsed light, and blue light in photodynamic therapy for acne vulgaris. ( Taub, AF, 2007)
"Intractable acne on the body was clinically treated with photodynamic therapy (PDT) combining oral administration of delta-aminolevulinic acid (ALA) with polychromatic visible light from a metal halide lamp."	5.11	Delta-aminolevulinic acid-based photodynamic therapy for acne on the body. ( Itoh, Y; Kawashima, N; Kimura, M; Tokuoka, Y, 2004)
"After completing this learning activity, participants should be able to analyze photodynamic therapy using 5-aminolevulinic acid and its derivates for acne treatment, predict the effectiveness and outcomes of photodynamic therapy using different parameters and/or different porphyrin-related photosensitizers, and assess and manage the side effects of porphyrin-based photodynamic therapy for acne."	4.86	Photodynamic therapy for acne vulgaris: a critical review from basics to clinical practice: part II. Understanding parameters for acne treatment with photodynamic therapy. ( Anderson, RR; Sakamoto, FH; Torezan, L, 2010)
"A literature review and results of new clinical trials with regards to photorejuvenation and acne vulgaris treatments with 5-aminolevulinic acid photodynamic therapy are presented."	4.82	5-aminolevulinic acid photodynamic therapy: where we have been and where we are going. ( Gold, MH; Goldman, MP, 2004)
"Short-contact, full-face 5-aminolevulinic acid photodynamic therapy treatments with a variety of lasers and light sources have shown to be successful in treating all facets of photorejuvenation and the associated actinic keratoses as well as disorders of sebaceous glands, including acne vulgaris."	4.82	5-aminolevulinic acid photodynamic therapy: where we have been and where we are going. ( Gold, MH; Goldman, MP, 2004)
"We report the case of a 20-year-old man with acne conglobata (AC) who was treated with 5-aminolevulinic acid photodynamic therapy (ALA-PDT) sequentially to deroofing, and finally used fractional carbon dioxide laser for esthetic requirements, achieving satisfying results."	4.12	A case of 5-aminolevulinic acid photodynamic therapy(ALA-PDT)combined with surgery for the treatment of acne conglobata. ( Bu, WB; Fang, F; Wu, QY; Zhang, Q, 2022)
"To study the clinical efficacy, recurrence rate and safety of 5-aminolevulinic acid-based photodynamic therapy (ALA-PDT) combined with microneedle or CO2 lattice laser (CO2FL), in comparison with intrascar betamethasone injection in the treatment of hypertrophic acne scar."	4.12	A clinical study of carbon dioxide lattice laser-assisted or microneedle-assisted 5-aminolevulinic acid-based photodynamic therapy for the treatment of hypertrophic acne scars. ( Huang, F; Li, C; Li, X; Tian, Y; Xia, A; Yan, D; Yun, Q; Zhang, J; Zhang, S; Zhao, H, 2022)
"Aminolevulinic acid-photodynamic therapy (ALA-PDT) has been an effective treatment for moderate to severe acne."	4.02	Modulation of skin microbiome in acne patients by aminolevulinic acid-photodynamic therapy. ( Ge, Y; Tao, S; Yang, Y; Zeng, R; Zheng, H, 2021)
"5-aminolevulinic acid mediated photodynamic therapy (ALA-PDT) is increasingly used to control severe acne."	4.02	The effects of ALA-PDT on microbiota in pilosebaceous units of patients with severe acne: A metagenomic study. ( Ge, Y; Qian, Q; Quan, C; Tao, S; Wang, Z, 2021)
"A case report of massive mandibular keloid with severe infection induced by acne achieved resolution of skin lesions after combined treatment with surgery and high concentration single-dose 5-aminolevulinic acid photodynamic therapy (5-ALA PDT)."	4.02	A massive mandibular keloid with severe infection: What is your treatment? ( Chen, XD; Gao, LM; Wu, XY; Zhao, LT, 2021)
"To evaluate the state of psychology and quality of life of patients effected by acne and also the efficacy and safety of photodynamic therapy with topical 5-aminolevulinic acid (ALA-PDT) for moderate to severe acne patients."	4.02	The assessment of psychology, quality of life in acne patients and evaluation of ALA-PDT for moderate to severe acne. ( Guo, H; Liu, Y; Sun, Y; Tu, C; Wu, H; Wu, Y; Xiao, B; Zhang, Y, 2021)
"Aminolevulinic acid (ALA) photodynamic therapy (PDT) is an emerging modality in the treatment of acne."	3.85	Utilizing non-ablative fractional photothermolysis prior to ALA-photodynamic therapy in the treatment of acne vulgaris: a case series. ( Lin, JY; Qureshi, S, 2017)
"To evaluate the efficacy and safety of topical 5-aminolevulinic acid (ALA) mediated photodynamic therapy (PDT) for the treatment of severe acne vulgaris."	3.83	Efficacy of 3.6% topical ALA-PDT for the treatment of severe acne vulgaris. ( Cao, L; Fan, H; Fan, Y; Li, F; Tao, SQ; Xia, RS; Yang, LJ, 2016)
"Propionibacterium acnes naturally produces endogenous porphyrins that are composed of coproporphyrin III (CPIII) and protoporphyrin IX (PpIX)."	3.77	Comparative study of the bactericidal effects of 5-aminolevulinic acid with blue and red light on Propionibacterium acnes. ( Beom, HJ; Choi, MS; Lee, JB; Park, HR; Yun, SJ, 2011)
"To observe the efficacy of 5-aminolevulinic acid photodynamic therapy (ALA-PDT) for treating psoriasis vulgaris in guinea pigs."	3.77	[Therapeutic effect of photodynamic treatment for psoriasis vulgaris in guinea pigs]. ( Duan, SJ; Li, KY; Liu, HW; Xie, GH, 2011)
" PDT using aminolevulinic acid (5-ALA) has attracted attention in the treatment of acne vulgaris."	3.74	Efficacy of ALA-PDT vs blue light in the treatment of acne. ( Akaraphanth, R; Gritiyarangsan, P; Kanjanawanitchkul, W, 2007)
"C-PDT in the treatment of acne vulgaris."	2.94	Conventional versus daylight photodynamic therapy for acne vulgaris: A randomized and prospective clinical study in China. ( Liu, X; Shi, L; Wang, P; Wang, X; Zhang, G; Zhang, H; Zhang, L; Zhang, Y; Zhao, Y; Zhou, Z, 2020)
"Acne vulgaris is a chronic inflammatory skin disease, commonly treated with topical or systemic drugs, according to the severity of the condition."	2.90	The efficacy and tolerability of 5-aminolevulinic acid 5% thermosetting gel photodynamic therapy (PDT) in the treatment of mild-to-moderate acne vulgaris. A two-center, prospective assessor-blinded, proof-of-concept study. ( Bianchi, L; Campione, E; Cannizzaro, MV; Dattola, A; Del Duca, E; Garofalo, V; Milani, M; Serini, SM; Ventura, A, 2019)
"Acne vulgaris is one of the most common dermatological problems, and its therapeutic options include topical and systemic retinoids and antibiotics."	2.87	Comparative study of the bactericidal effects of indocyanine green- and methyl aminolevulinate-based photodynamic therapy on Propionibacterium acnes as a new treatment for acne. ( Choi, SH; Kim, KH; Seo, JW, 2018)
"P."	2.87	Comparative study of the bactericidal effects of indocyanine green- and methyl aminolevulinate-based photodynamic therapy on Propionibacterium acnes as a new treatment for acne. ( Choi, SH; Kim, KH; Seo, JW, 2018)
"Pain was low and manageable by briefly pausing illumination."	2.82	Photodynamic therapy with methyl aminolaevulinate 80 mg g(-1) for severe facial acne vulgaris: a randomized vehicle-controlled study. ( Bukhalo, M; Eichenfield, LF; Jarratt, M; Pariser, DM; Waterman, G, 2016)
" Only a few patients expressed mild adverse effects."	2.82	Daylight photodynamic therapy with 1.5% 3-butenyl 5-aminolevulinate gel as a convenient, effective and safe therapy in acne treatment: A double-blind randomized controlled trial. ( Kwon, HH; Lee, JB; Moon, KR; Park, SY; Suh, DH; Yoon, JY, 2016)
"Severe acne vulgaris has limited therapeutic options."	2.82	Photodynamic therapy with methyl aminolaevulinate 80 mg g(-1) for severe facial acne vulgaris: a randomized vehicle-controlled study. ( Bukhalo, M; Eichenfield, LF; Jarratt, M; Pariser, DM; Waterman, G, 2016)
"Scarring is a very common complication of severe acne and is difficult to treat by conventional methods."	2.79	Combination ALA-PDT and ablative fractional Er:YAG laser (2,940 nm) on the treatment of severe acne. ( Hamblin, MR; Hao, F; Lin, L; Xiao, Y; Yin, R, 2014)
"The efficacy for lichenoid dermatoses was dependent on the clinical variant (erosive and scleroatrophic were more responsive than hypertrophic)."	2.78	A retrospective analysis of real-life practice of off-label photodynamic therapy using methyl aminolevulinate (MAL-PDT) in 20 Italian dermatology departments. Part 1: inflammatory and aesthetic indications. ( Aronson, E; Calzavara-Pinton, PG; Rossi, MT; Sala, R, 2013)
"An alternative approach in the treatment of acne vulgaris is photodynamic therapy (PDT) that uses light and aminolevulinic acid (ALA)-induced protoporphyrin IX (PpIX) production to eradicate Propionibacterium acnes found in acne lesions."	2.75	Radiant near infrared light emitting Diode exposure as skin preparation to enhance photodynamic therapy inflammatory type acne treatment outcome. ( Barolet, D; Boucher, A, 2010)
"acnes was measured in a skin surface biopsy using a cyano-acrylate polymer to extract the content of the sebaceous follicles."	2.73	Photodynamic therapy for acne vulgaris: a pilot study of the dose-response and mechanism of action. ( Faergemann, J; Hörfelt, C; Larkö, O; Stenquist, B; Wennberg, AM, 2007)
" The study reported herein evaluated the effect on acne vulgaris of IPL alone and when IPL was combined with photodynamic therapy (PDT) using topical methyl aminolevulinate (MAL) in Asians."	2.73	A comparative study of intense pulsed light alone and its combination with photodynamic therapy for the treatment of facial acne in Asian skin. ( Bjerring, P; Chan, HH; Kono, T; Shek, SY; Yeung, CK; Yu, CS, 2007)
"Hyperpigmentation was more common at higher doses of light, and pain was experienced more often by the patients when higher doses were used."	2.73	Photodynamic therapy for acne vulgaris: a pilot study of the dose-response and mechanism of action. ( Faergemann, J; Hörfelt, C; Larkö, O; Stenquist, B; Wennberg, AM, 2007)
" Cosmetically well-accepted, LP PDL PDT combined with topical therapy is the first PDT modality to achieve complete clearance with long-term follow-up as compared to controls."	2.72	Long-pulsed dye laser-mediated photodynamic therapy combined with topical therapy for mild to severe comedonal, inflammatory, or cystic acne. ( Alexiades-Armenakas, M, 2006)
"Acne affects 83-95% of 16-year-olds of both sexes, and many seek help from a clinician."	2.71	Topical aminolaevulinic acid-photodynamic therapy for the treatment of acne vulgaris: a study of clinical efficacy and mechanism of action. ( Bojar, RA; Cunliffe, WJ; Goulden, V; Pollock, B; Stables, GI; Stringer, MR; Turner, D, 2004)
"acnes is suggested from the results of this study."	2.71	Topical aminolaevulinic acid-photodynamic therapy for the treatment of acne vulgaris: a study of clinical efficacy and mechanism of action. ( Bojar, RA; Cunliffe, WJ; Goulden, V; Pollock, B; Stables, GI; Stringer, MR; Turner, D, 2004)
"PDT was beneficial in the treatment of acne."	2.70	Photodynamic therapy of acne vulgaris with topical delta-aminolaevulinic acid and incoherent light in Japanese patients. ( Ishibashi, A; Itoh, Y; Ninomiya, Y; Tajima, S, 2001)
"Whereas the standard approach to the treatment of acne vulgaris has involved both systemic and topical antibiotics and topical agents such as benzoyl peroxide, problems exist due to side effects, drug resistance and lack of compliance."	2.47	The use of photosensitisers in acne treatment. ( Flint, C; Smalley, H; Wainwright, M, 2011)
"The first-line treatments for acne vulgaris are conventional topical and/or oral medications."	2.46	Photodynamic therapy for acne vulgaris: a critical review from basics to clinical practice: part I. Acne vulgaris: when and why consider photodynamic therapy? ( Anderson, RR; Lopes, JD; Sakamoto, FH, 2010)
"Acne is the eighth-most prevalent inflammatory skin disease with no optimal treatment."	1.91	Photodynamic therapy treats acne by altering the composition of the skin microbiota. ( Chen, Y; Guo, Y; Jiao, X; Liu, R; Lu, T; Ruan, Z; Xie, Q; Yu, H; Yuan, M; Yuan, Y; Zeng, M, 2023)
"Severe acne vulgaris is a common chronic inflammatory skin disease worldwide."	1.91	ALA-PDT augments intense inflammation in the treatment of acne vulgaris by COX2/TREM1 mediated M1 macrophage polarization. ( Liu, P; Liu, X; Wang, P; Wang, X; Wu, Y; Xu, D; Yan, G; Zeng, Q; Zhang, G; Zhang, H; Zhang, L, 2023)
"Acne vulgaris is a common skin disease caused by multifactorial reasons involving excessive sebum secretion and inflammation by Cutibacterium acnes (C."	1.91	Topical methylene blue nanoformulation for the photodynamic therapy of acne vulgaris. ( Bang, J; Han, S; Kim, BR; Kim, S; Lee, YD; Shin, JW; Yang, JK, 2023)
"Acne vulgaris is a chronic inflammatory skin disease around pilosebaceous unit."	1.72	A prospective study of adverse reactions of ALA-PDT for acne vulgaris. ( Liu, X; Shi, L; Wang, P; Wang, X; Yan, G; Yang, J; Zhang, G; Zhang, H; Zhang, L; Zhang, Y; Zhou, Z, 2022)
"P."	1.72	Hexyl-aminolevulinate ethosome-mediated photodynamic therapy against acne: in vitro and in vivo analyses. ( Song, J; Wang, T; Wang, Y; Wu, L; Zhang, F; Zhu, X, 2022)
"Acne vulgaris is a chronic inflammatory skin disease around pilosebaceous unit."	1.62	5-Aminolaevulinic acid photodynamic therapy suppresses lipid secretion of primary sebocytes through AMPK/SREBP-1 pathway. ( Liu, J; Liu, X; Shi, L; Wang, X; Xu, D; Yang, J; Zeng, Q; Zhang, L, 2021)
"Acne vulgaris is a chronic inflammatory disease that frequently occurs in adolescence."	1.62	Daylight photodynamic therapy with 5-aminolevulinic acid 5% gel for the treatment of mild-to-moderate inflammatory acne. ( Bennardo, L; Cannarozzo, G; Chester, J; Del Duca, E; Farnetani, F; Manfredini, M; Nisticò, SP; Pellacani, G; Petrini, N; Sannino, M; Schipani, G; Tamburi, F, 2021)
"Acne vulgaris is a chronic inflammatory cutaneous disease."	1.62	5-Aminolaevulinic acid photodynamic therapy amplifies intense inflammatory response in the treatment of acne vulgaris via CXCL8. ( Liu, J; Liu, X; Shi, L; Wang, X; Xu, D; Yang, J; Zeng, Q; Zhang, L, 2021)
"The first-line treatments for acne vulgaris are topical and oral medications, mainly antibiotics and retinoids."	1.56	Thermomechanical Ablation-Assisted Photodynamic Therapy for the Treatment of Acne Vulgaris. A Retrospective Chart Review of 30 Patients. ( Artzi, O; Friedman, O; Hilerowicz, Y; Koren, A; Mehrabi, JN; Salameh, F; Ziv, R; Zur, E, 2020)
"Acne is a common skin disease in adolescence."	1.48	Severe acne in monozygotic twins treated with photodynamic therapy. ( Li, SS; Lv, T; Nie, S; Wang, HW; Zhang, LL, 2018)
"Subjects referred for treatment of acne refractory to several topical and oral regimens, including isotretinoin, were pre-treated with non-ablative fractional photothermolysis (NAFP)."	1.46	Utilizing non-ablative fractional photothermolysis prior to ALA-photodynamic therapy in the treatment of acne vulgaris: a case series. ( Lin, JY; Qureshi, S, 2017)
"Acne vulgaris is one of the most common skin diseases in adolescents."	1.42	Prospective study of topical 5-aminolevulinic acid photodynamic therapy for the treatment of severe adolescent acne in Chinese patients. ( Liu, Y; Ma, Y; Ren, J; Wang, Q; Xiang, L, 2015)
"acnes."	1.37	Comparative study of the bactericidal effects of 5-aminolevulinic acid with blue and red light on Propionibacterium acnes. ( Beom, HJ; Choi, MS; Lee, JB; Park, HR; Yun, SJ, 2011)
"Acne vulgaris is a common dermatological disorder."	1.37	Successful treatment of refractory facial acne using repeat short-cycle ALA-PDT: Case study. ( Ding, HL; Huang, Z; Wang, HW; Wang, XL, 2011)
"Propionibacterium acnes is a Gram-positive, microaerophilic bacterium that causes skin wounds."	1.32	Eradication of Propionibacterium acnes by its endogenic porphyrins after illumination with high intensity blue light. ( Ashkenazi, H; Harth, Y; Malik, Z; Nitzan, Y, 2003)

Research

Studies (122)

Authors

Clinical Trials (4)

Trial Overview

Trial Outcomes

Global Face Closed Comedones Count - Week 12

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	1 (0.82)	18.2507
2000's	43 (35.25)	29.6817
2010's	47 (38.52)	24.3611
2020's	31 (25.41)	2.80

Authors	Studies
Wojewoda, K	1
Gillstedt, M	1
Tovi, J	1
Salah, L	1
Wennberg Larkö, AM	1
Sjöholm, A	1
Sandberg, C	1
Yang, J	5
Shi, L	7
Xu, D	3
Liu, J	3
Zhang, L	7
Liu, X	6
Zeng, Q	3
Wang, X	8
Wu, HE	3
Liu, YB	4
Xu, GJ	3
Sun, XD	3
Wang, Q	4
Yang, Y	2
Tao, S	2
Zeng, R	1
Zheng, H	1
Ge, Y	2
Zhang, Y	4
Yan, G	2
Zhang, H	4
Wang, P	5
Zhang, G	4
Zhou, Z	3
Wu, QY	1
Zhang, Q	1
Bu, WB	1
Fang, F	2
Yu, Y	1
Li, J	1
Zou, Y	1
Yin, R	4
Lee, YD	1
Yang, JK	1
Han, S	1
Kim, BR	1
Shin, JW	1
Bang, J	1
Kim, S	1
Liu, P	2
Wu, Y	4
Guo, Y	1
Zeng, M	1
Yuan, Y	1
Yuan, M	1
Chen, Y	1
Yu, H	1
Liu, R	1
Ruan, Z	1
Xie, Q	1
Jiao, X	1
Lu, T	1
Chen, Q	2
Li, L	1
Song, ZQ	1
Ge, L	1
Wang, B	2
Zhao, Y	2
Lv, T	2
Wei, Z	1
Wang, R	1
Wong, H	1
Ju, Q	1
Chen, YT	1
Lin, YJ	1
Chang, CC	1
Liu, PH	1
Huang, YH	1
Shen, JW	1
Lu, ME	1
Chiang, HM	1
Lin, BS	1
Del Duca, E	2
Manfredini, M	1
Petrini, N	1
Farnetani, F	1
Chester, J	1
Bennardo, L	1
Schipani, G	1
Tamburi, F	1
Sannino, M	1
Cannarozzo, G	1
Pellacani, G	1
Nisticò, SP	1
Lee, HJ	1
Kim, JY	2
Park, KD	1
Lee, WJ	2
Hao, J	1
Wang, T	2
Hilerowicz, Y	1
Friedman, O	1
Zur, E	1
Ziv, R	1
Koren, A	2
Salameh, F	1
Mehrabi, JN	1
Artzi, O	2
Marcus, S	1
Monfrecola, G	2
Megna, M	1
Rovati, C	1
Arisi, M	1
Rossi, M	1
Calzavara-Pinton, I	1
Fabbrocini, G	2
Calzavara-Pinton, P	1
Wang, Z	1
Quan, C	1
Qian, Q	1
Zhao, LT	1
Gao, LM	1
Chen, XD	1
Wu, XY	1
Liu, L	1
Wei, G	1
Meng, L	1
Zhang, C	2
Wu, H	1
Tu, C	1
Sun, Y	1
Xiao, B	1
Guo, H	1
Liu, Y	3
Wu, L	1
Wang, Y	1
Song, J	1
Zhang, F	1
Zhu, X	1
Cui, L	2
Qin, P	1
Han, XW	1
Yan, D	1
Zhao, H	1
Li, C	1
Xia, A	1
Zhang, J	2
Zhang, S	1
Yun, Q	1
Li, X	1
Huang, F	1
Tian, Y	1
Slutsky-Bank, E	1
Sprecher, E	1
Barbaric, J	1
Abbott, R	1
Posadzki, P	1
Car, M	1
Gunn, LH	1
Layton, AM	1
Majeed, A	1
Car, J	1
Kim, TI	1
Ahn, HJ	1
Kang, IH	1
Jeong, KH	1
Kim, NI	1
Shin, MK	1
Wen, X	1
Li, Y	1
Hamblin, MR	2
Theresia, C	1
Zheng, J	1
Chen, XY	1
Choi, SH	1
Seo, JW	1
Kim, KH	1
Serini, SM	1
Cannizzaro, MV	1
Dattola, A	1
Garofalo, V	1
Ventura, A	1
Milani, M	1
Campione, E	1
Bianchi, L	1
Li, SS	1
Zhang, LL	3
Nie, S	1
Wang, HW	3
Nicklas, C	1
Rubio, R	1
Cárdenas, C	1
Hasson, A	1
Zheng, Z	1
Zhang, YF	1
Wu, QQ	1
Wang, WQ	1
Sroka, R	1
Wang, XL	4
Mei, X	1
Shi, W	1
Piao, Y	1
Ma, L	1
Xiang, LH	1
Yu, B	1
Chen, L	1
Tan, ZJ	1
Tian, HQ	1
Li, HZ	1
Lin, T	1
Li, YH	1
Wang, WZ	1
Yang, HL	1
Lai, W	1
Lin, L	1
Xiao, Y	1
Hao, F	2
Ma, Y	2
Ren, J	1
Xiang, L	2
Kwon, HH	1
Moon, KR	1
Park, SY	1
Yoon, JY	2
Suh, DH	2
Lee, JB	2
Pariser, DM	1
Eichenfield, LF	1
Bukhalo, M	1
Waterman, G	1
Jarratt, M	1
Yuan, D	1
Liu, W	1
Chen, J	1
Lin, X	1
Cheng, S	1
Li, F	3
Duan, X	1
Dessinioti, C	1
Masouri, S	1
Drakaki, E	1
Katsambas, A	1
Antoniou, C	1
Tao, SQ	2
Xia, RS	2
Cao, L	2
Fan, H	2
Fan, Y	2
Yang, LJ	2
Taylor, M	1
Sun, H	1
Jing, C	1
Huang, Z	4
Qureshi, S	1
Lin, JY	1
Kumar, N	1
Warren, CB	1
Ryou, JH	1
Lee, SJ	2
Park, YM	1
Kim, HO	1
Kim, HS	1
Serrano, G	1
Lorente, M	1
Reyes, M	1
Millán, F	1
Lloret, A	1
Melendez, J	1
Navarro, M	2
Terrell, S	1
Aires, D	1
Schweiger, ES	1
Hörfelt, C	3
Stenquist, B	2
Halldin, CB	1
Ericson, MB	1
Wennberg, AM	3
Oh, SH	1
Ryu, DJ	1
Han, EC	1
Lee, KH	1
Lee, JH	1
de Leeuw, J	1
van der Beek, N	1
Bjerring, P	2
Neumann, HA	1
Cacciapuoti, S	1
De Vita, V	1
Fardella, N	1
Pastore, F	1
Barolet, D	1
Boucher, A	1
Guo, MX	1
Sadick, N	1
Orringer, JS	1
Sachs, DL	1
Bailey, E	1
Kang, S	1
Hamilton, T	1
Voorhees, JJ	1
Deng, J	1
Yang, XC	1
Yan, H	1
Sakamoto, FH	2
Torezan, L	1
Anderson, RR	3
Lopes, JD	1
Wang, H	1
García-Morales, I	1
Harto, A	1
Fernández-Guarino, M	1
Jaén, P	1
Bissonnette, R	2
Maari, C	1
Nigen, S	1
Provost, N	1
Bolduc, C	1
An, JS	1
Kim, JE	1
Lee, DH	1
Kim, BY	1
Cho, S	1
Kwon, IH	1
Choi, WW	1
Kang, SM	1
Won, CH	1
Chang, SE	1
Lee, MW	1
Choi, JH	1
Moon, KC	1
Choi, MS	1
Yun, SJ	1
Beom, HJ	1
Park, HR	1
Yeung, CK	2
Shek, SY	2
Yu, CS	2
Kono, T	2
Chan, HH	2
Taub, AF	3
Xie, GH	1
Li, KY	1
Liu, HW	1
Duan, SJ	1
Kosaka, S	1
Miyoshi, N	1
Akilov, OE	1
Hasan, T	1
Kawana, S	1
Wainwright, M	1
Smalley, H	1
Flint, C	1
Ding, HL	1
Lee, Y	1
Baron, ED	1
Jung, HJ	1
Kim, DW	1
Calzavara-Pinton, PG	1
Rossi, MT	1
Aronson, E	1
Sala, R	1
Hong, JS	1
Jung, JY	1
Ashkenazi, H	1
Malik, Z	1
Harth, Y	1
Nitzan, Y	1
Touma, DJ	1
Gilchrest, BA	1
Goldman, MP	2
Boyce, SM	1
Gold, MH	6
Pollock, B	1
Turner, D	1
Stringer, MR	1
Bojar, RA	1
Goulden, V	1
Stables, GI	1
Cunliffe, WJ	1
Kimura, M	1
Itoh, Y	3
Tokuoka, Y	1
Kawashima, N	1
Santos, MA	1
Belo, VG	1
Santos, G	1
Hong, SB	1
Lee, MH	1
Alexiades-Armenakas, M	2
Richey, DF	1
Ortiz, A	1
Van Vliet, M	1
Lask, GP	1
Yamauchi, PS	1
Wiegell, SR	3
Wulf, HC	3
Rivard, J	1
Ozog, D	1
Funk, J	1
Frohm-Nilsson, M	1
Wiegleb Edström, D	1
Rojanamatin, J	1
Choawawanich, P	1
Nestor, MS	1
Katz, BE	1
Truong, S	1
Maiwald, DC	1
Frew, KE	1
George, D	1
Biron, JA	1
Boring, M	1
Bridges, TM	1
Bradshaw, VL	1
Storjord, E	1
Brekke, OL	1
Nielsen, EW	1
Larkö, O	1
Faergemann, J	1
Mavilia, L	1
Malara, G	1
Moretti, G	1
Lo Re, M	1
Puglisi Guerra, A	1
Akaraphanth, R	1
Kanjanawanitchkul, W	1
Gritiyarangsan, P	1
Haedersdal, M	1
Togsverd-Bo, K	1
Cheng, WN	1
Coenraads, PJ	1
Hao, ZH	1
Liu, GF	1
Hongcharu, W	1
Taylor, CR	1
Chang, Y	1
Aghassi, D	1
Suthamjariya, K	1
Ninomiya, Y	2
Tajima, S	2
Ishibashi, A	2
Rudolph, RI	1
Ibbotson, SH	1
Zhang, X	1
He, Y	1
Wu, X	1
Huang, J	1
Huang, H	1
Lu, C	1

Trial	Enrollment	Study Type	Start Date	Status
"A Comprehensive Intervention to Improve the Level of Cleaning and Disinfection of Patients' Units, in Order to Reduce New Acquisitions and Environmental Contamination by Multidrug Resistant Organisms: a Prospective Controlled Crossover Trial, Using VYV L[NCT05973916]	1,400 participants (Anticipated)	Interventional	2023-08-03	Not yet recruiting
A Multi-Center, Evaluator Blinded, Randomized Clinical Study to Evaluate the Efficacy and Tolerance of Two Acne Treatment Regimens on Subjects With Mild to Moderate Acne Vulgaris[NCT03124381]	126 participants (Actual)	Interventional	2017-04-08	Completed
Safety and Preliminary Efficacy of Combination Blue Light Phototherapy and Microcurrent Therapy for the Treatment of Acne Vulgaris[NCT02431494]	4 participants (Actual)	Interventional	2014-10-30	Terminated (stopped due to Lack of recruitment)
A Multi-Center, Evaluator Blinded, Randomized Clinical Study to Evaluate the Efficacy and Tolerance of Two Acne Treatments on Subjects With Mild to Moderate Acne Vulgaris[NCT02698436]	103 participants (Actual)	Interventional	2016-03-31	Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Closed comedones count on global face - Week 12 (NCT03124381)
Timeframe: 12 weeks

Global Face Closed Comedones Count - Week 2

Global Face Closed Comedones Count - Week 4

Global Face Closed Comedones Count - Week 8

Global Face Inflammatory Lesion Count - Week 12

Global Face Inflammatory Lesion Count - Week 2

Global Face Inflammatory Lesion Count - Week 4

Global Face Inflammatory Lesion Count - Week 8

Global Face Non-Inflammatory Lesion Count - Week 12

Global Face Non-Inflammatory Lesion Count - Week 2

Global Face Non-Inflammatory Lesion Count - Week 4

Global Face Non-Inflammatory Lesion Count - Week 8

Global Face Open Comedones Count - Week 12

Global Face Open Comedones Count - Week 2

Global Face Open Comedones Count - Week 4

Global Face Open Comedones Count - Week 8

Global Face Total Lesion Count - Percent Change - Baseline to Week 12

Intervention	Closed Comedones (Mean)
Gel-Cream + Acne Mask	11.9
Acne Mask	10.2

Intervention	Closed Comedones (Mean)
Gel-Cream + Acne Mask	14.7
Acne Mask	12.7

Intervention	Closed Comedones (Mean)
Gel-Cream + Acne Mask	14.1
Acne Mask	10.9

Intervention	Closed Comedones (Mean)
Gel-Cream + Acne Mask	12.7
Acne Mask	10.3

Intervention	Inflammatory Lesions (Mean)
Gel-Cream + Acne Mask	9.7
Acne Mask	7.7

Intervention	Inflammatory Lesions (Mean)
Gel-Cream + Acne Mask	12.1
Acne Mask	10.3

Intervention	Inflammatory Lesions (Mean)
Gel-Cream + Acne Mask	10.8
Acne Mask	9.1

Intervention	Inflammatory Lesions (Mean)
Gel-Cream + Acne Mask	9.9
Acne Mask	7.8

Intervention	Non-inflammatory Lesions (Mean)
Gel-Cream + Acne Mask	15.6
Acne Mask	14.0

Intervention	Non-inflammatory Lesions (Mean)
Gel-Cream + Acne Mask	22.7
Acne Mask	18.3

Intervention	Non-inflammatory lesions (Mean)
Gel-Cream + Acne Mask	22.0
Acne Mask	16.2

Intervention	Non-inflammatory Lesions (Mean)
Gel-Cream + Acne Mask	17.8
Acne Mask	14.8

Intervention	Open Comedones (Mean)
Gel-Cream + Acne Mask	3.6
Acne Mask	3.7

Intervention	Open Comedones (Mean)
Gel-Cream + Acne Mask	8.1
Acne Mask	5.6

Intervention	Open Comedones (Mean)
Gel-Cream + Acne Mask	7.9
Acne Mask	5.3

Intervention	Open Comedones (Mean)
Gel-Cream + Acne Mask	5.1
Acne Mask	4.5

Percent change from baseline in global face total lesion count at Week 12 (NCT03124381)
Timeframe: Baseline and Week 12

Global Face Total Lesion Count - Percent Change - Baseline to Week 2

Intervention	Percent Change in Lesions (Mean)
Gel-Cream + Acne Mask	-42.64
Acne Mask	-47.80

Percent change from baseline in global face total lesion count at Week 2 (NCT03124381)
Timeframe: Baseline and Week 2

Global Face Total Lesion Count - Percent Change - Baseline to Week 4

Intervention	Percent Change in Lesions (Mean)
Gel-Cream + Acne Mask	-24.16
Acne Mask	-27.97

Percent change from baseline in global face total lesion count at Week 4 (NCT03124381)
Timeframe: Baseline and Week 4

Global Face Total Lesion Count - Percent Change - Baseline to Week 8

Intervention	Percent Change in Lesions (Mean)
Gel-Cream + Acne Mask	-29.78
Acne Mask	-38.25

Percent change from baseline in global face total lesion count at Week 8 (NCT03124381)
Timeframe: Baseline and Week 8

Global Face Total Lesion Count - Percent Change From Baseline to the Mean of All Visits

Intervention	Percent Change in Lesions (Mean)
Gel-Cream + Acne Mask	-39.81
Acne Mask	-45.86

Global face total lesion counts are averaged across all applicable post-baseline visits (Week 2, Week 4, Week 8, and Week 12). Percent change from baseline to the mean is then calculated. (NCT03124381)
Timeframe: Baseline to Week 2, Week 4, Week 8, and Week 12

Global Face Total Lesion Count - Percent Change From Baseline to the Mean of Week 2 and Week 4

Intervention	Percent Change in Lesions (Mean)
Gel-Cream + Acne Mask	-33.68
Acne Mask	-39.79

Global face total lesion counts are averaged across Week 2 and Week 4. Percent change from baseline to the mean is then calculated. (NCT03124381)
Timeframe: Baseline to Week 2 and Week 4

Global Face Total Lesion Count - Percent Change From Baseline to the Mean of Week 4 and Week 8

Intervention	Percent Change in Lesions (Mean)
Gel-Cream + Acne Mask	-26.95
Acne Mask	-33.01

Global face total lesion counts are averaged across Week 4 and Week 8. Percent change from baseline to the mean is then calculated. (NCT03124381)
Timeframe: Baseline to Week 4 and Week 8

Global Face Total Lesion Count - Percent Change From Baseline to the Mean of Week 8 and Week 12

Intervention	Percent Change in Lesions (Mean)
Gel-Cream + Acne Mask	-34.34
Acne Mask	-42.09

Global face total lesion counts are averaged across Week 8 and Week 12. Percent change from baseline to the mean is then calculated. (NCT03124381)
Timeframe: Baseline to Week 8 and Week 12

Global Face Total Lesion Count - Week 12

Intervention	Percent Change in Lesions (Mean)
Gel-Cream + Acne Mask	-41.73
Acne Mask	-47.25

Sum of inflammatory and non-inflammatory lesions (NCT03124381)
Timeframe: 12 weeks

Global Face Total Lesion Count - Week 2

Intervention	Lesions (Mean)
Gel-Cream + Acne Mask	25.3
Acne Mask	21.7

Sum of inflammatory and non-inflammatory lesions (NCT03124381)
Timeframe: 2 weeks

Global Face Total Lesion Count - Week 4

Intervention	Lesions (Mean)
Gel-Cream + Acne Mask	34.8
Acne Mask	28.6

Sum of inflammatory and non-inflammatory lesions (NCT03124381)
Timeframe: 4 weeks

Global Face Total Lesion Count - Week 8

Intervention	Lesions (Mean)
Gel-Cream + Acne Mask	32.8
Acne Mask	25.2

Sum of inflammatory and non-inflammatory lesions (NCT03124381)
Timeframe: 8 weeks

Investigator Global Acne Assessment - Week 1

Intervention	Lesions (Mean)
Gel-Cream + Acne Mask	27.7
Acne Mask	22.5

Investigator Global Acne Assessment using Modified Cooke's Scale - Week 1. Modified Cooke's scale ranges from 0 = clear/no acne to 5 = very severe acne. Half-points are allowed. (NCT03124381)
Timeframe: 1 week

Investigator Global Acne Assessment - Week 12

Intervention	Units on a scale (Mean)
Gel-Cream + Acne Mask	2.29
Acne Mask	2.27

Investigator Global Acne Assessment using Modified Cooke's Scale - Week 12. Modified Cooke's scale ranges from 0 = clear/no acne to 5 = very severe acne. Half-points are allowed. (NCT03124381)
Timeframe: 12 weeks

Investigator Global Acne Assessment - Week 2

Intervention	Units on a scale (Mean)
Gel-Cream + Acne Mask	1.64
Acne Mask	1.64

Investigator Global Acne Assessment using Modified Cooke's Scale - Week 2. Modified Cooke's scale ranges from 0 = clear/no acne to 5 = very severe acne. Half-points are allowed. (NCT03124381)
Timeframe: 2 weeks

Investigator Global Acne Assessment - Week 4

Intervention	Units on a scale (Mean)
Gel-Cream + Acne Mask	2.17
Acne Mask	2.06

Investigator Global Acne Assessment using Modified Cooke's Scale - Week 4. Modified Cooke's scale ranges from 0 = clear/no acne to 5 = very severe acne. Half-points are allowed. (NCT03124381)
Timeframe: 4 weeks

Investigator Global Acne Assessment - Week 8

Intervention	Units on a scale (Mean)
Gel-Cream + Acne Mask	2.00
Acne Mask	1.90

Investigator Global Acne Assessment using Modified Cooke's Scale - Week 8. Modified Cooke's scale ranges from 0 = clear/no acne to 5 = very severe acne. Half-points are allowed. (NCT03124381)
Timeframe: 8 weeks

Overall Redness of Inflammatory Lesions - Week 1

Intervention	Units on a scale (Mean)
Gel-Cream + Acne Mask	1.84
Acne Mask	1.73

Additional investigator efficacy assessment. 0-9 scale where 0 = no redness associated with the inflammatory lesions; 9 = overall, inflammatory lesions exhibit severe degree of redness (NCT03124381)
Timeframe: 1 week

Overall Redness of Inflammatory Lesions - Week 12

Intervention	Units on a scale (Mean)
Gel-Cream + Acne Mask	4.88
Acne Mask	5.05

Overall Redness of Inflammatory Lesions - Week 2

Intervention	Units on a scale (Mean)
Gel-Cream + Acne Mask	3.96
Acne Mask	3.97

Overall Redness of Inflammatory Lesions - Week 4

Intervention	Units on a scale (Mean)
Gel-Cream + Acne Mask	4.65
Acne Mask	4.74

Overall Redness of Inflammatory Lesions - Week 8

Intervention	Units on a scale (Mean)
Gel-Cream + Acne Mask	4.49
Acne Mask	4.41

Overall Size of Inflammatory Lesions - Week 1

Intervention	Units on a scale (Mean)
Gel-Cream + Acne Mask	4.30
Acne Mask	4.25

Additional investigator efficacy assessment. 0-9 scale where 0 = no longer visible; 9 = overall size is very large (NCT03124381)
Timeframe: 1 week

Overall Size of Inflammatory Lesions - Week 12

Intervention	Units on a scale (Mean)
Gel-Cream + Acne Mask	4.58
Acne Mask	4.83

Additional investigator efficacy assessment. Additional investigator efficacy assessment. 0-9 scale where 0 = no longer visible; 9 = overall size is very large (NCT03124381)
Timeframe: 12 weeks

Overall Size of Inflammatory Lesions - Week 2

Intervention	Units on a scale (Mean)
Gel-Cream + Acne Mask	3.67
Acne Mask	3.59

Additional investigator efficacy assessment. Additional investigator efficacy assessment. 0-9 scale where 0 = no longer visible; 9 = overall size is very large (NCT03124381)
Timeframe: 2 weeks

Overall Size of Inflammatory Lesions - Week 4

Intervention	Units on a scale (Mean)
Gel-Cream + Acne Mask	4.17
Acne Mask	4.56

Additional investigator efficacy assessment. Additional investigator efficacy assessment. 0-9 scale where 0 = no longer visible; 9 = overall size is very large (NCT03124381)
Timeframe: 4 weeks

Overall Size of Inflammatory Lesions - Week 8

Intervention	Units on a scale (Mean)
Gel-Cream + Acne Mask	4.07
Acne Mask	4.15

Additional investigator efficacy assessment. Additional investigator efficacy assessment. 0-9 scale where 0 = no longer visible; 9 = overall size is very large. (NCT03124381)
Timeframe: 8 weeks

Acne Lesion Counts Total Global Face - Baseline

Intervention	Units on a scale (Mean)
Gel-Cream + Acne Mask	3.88
Acne Mask	3.85

Acne Lesion Count Total Global Face at Baseline (NCT02698436)
Timeframe: Baseline

Acne Lesion Counts Total Global Face - Week 1

Acne Lesion Counts Total Global Face - Week 12

Acne Lesion Counts Total Global Face - Week 2

Acne Lesion Counts Total Global Face - Week 4

Acne Lesion Counts Total Global Face - Week 8

Investigator Global Acne Assessment - Baseline

Intervention	Lesion Count (Mean)
Acne Mask	47.2
2.5% Benzoyl Peroxide	47.6

Intervention	Lesion Count (Mean)
Acne Mask	39.2
2.5% Benzoyl Peroxide	36.8

Intervention	Lesion Count (Mean)
Acne Mask	24.8
2.5% Benzoyl Peroxide	23.3

"Investigator's assessment of subject's acne condition using a score of 0 (best) and 5 (worst) on the Modified Cook's scale.~0 Clear Residual hyperpigmentation and erythema may be present.~Almost Clear. A few scattered comedones and a few (less than five) small papules.~Mild.Easily recognizable; less than half the face is involved. Many comedones and many papules and pustules.~Moderate More than half of the face is involved. Numerous comedones, papules and pustules.~Severe. Entire face is involved. Covered with comedones, numerous papules and pustules and few nodules and cysts.~Very Severe.Highly inflammatory acne covering the face; with nodules and cysts present." (NCT02698436)
Timeframe: Baseline

Investigator Global Acne Assessment - Week 1

Investigator Global Acne Assessment - Week 12

Investigator Global Acne Assessment - Week 2

Investigator Global Acne Assessment - Week 4

Investigator Global Acne Assessment - Week 8

Article	Year
A Critical Reappraisal of Off-Label Use of Photodynamic Therapy for the Treatment of Non-Neoplastic Skin Conditions. Dermatology (Basel, Switzerland), 2021, Volume: 237, Issue:2 Topics: Acne Vulgaris; Aminolevulinic Acid; Cosmetic Techniques; Humans; Lichen Sclerosus et Atrophicus; Off	2021
Light therapies for acne: abridged Cochrane systematic review including GRADE assessments. The British journal of dermatology, 2018, Volume: 178, Issue:1 Topics: Acne Vulgaris; Adult; Aminolevulinic Acid; Female; Gold Compounds; GRADE Approach; Humans; Infrared	2018
Photodynamic therapy in dermatology beyond non-melanoma cancer: An update. Photodiagnosis and photodynamic therapy, 2017, Volume: 19 Topics: Acne Vulgaris; Aminolevulinic Acid; Collagen; Humans; Photochemotherapy; Photosensitizing Agents; Po	2017
Topical ALA-PDT as alternative therapeutic option in treatment-recalcitrant dermatosis: Report of 4 cases. Photodiagnosis and photodynamic therapy, 2017, Volume: 20 Topics: Acne Vulgaris; Adolescent; Adult; Aged, 80 and over; Aminolevulinic Acid; Condylomata Acuminata; Fem	2017
Photodynamic therapy for dermatologic conditions in the pediatric population: a literature review. Photodermatology, photoimmunology & photomedicine, 2017, Volume: 33, Issue:3 Topics: Acne Vulgaris; Adolescent; Aminolevulinic Acid; Child; Child, Preschool; Humans; Infant; Infant, New	2017
Photodynamic therapy for acne vulgaris: a critical review from basics to clinical practice: part II. Understanding parameters for acne treatment with photodynamic therapy. Journal of the American Academy of Dermatology, 2010, Volume: 63, Issue:2 Topics: Acne Vulgaris; Aminolevulinic Acid; Dermatology; Education, Medical, Continuing; Humans; Laser Thera	2010
Photodynamic therapy for acne vulgaris: a critical review from basics to clinical practice: part I. Acne vulgaris: when and why consider photodynamic therapy? Journal of the American Academy of Dermatology, 2010, Volume: 63, Issue:2 Topics: Acne Vulgaris; Aminolevulinic Acid; Dermatology; Education, Medical, Continuing; Humans; Laser Thera	2010
The use of photosensitisers in acne treatment. Journal of photochemistry and photobiology. B, Biology, 2011, Oct-05, Volume: 105, Issue:1 Topics: Acne Vulgaris; Aminolevulinic Acid; Humans; Indocyanine Green; Phenothiazines; Photochemotherapy; Ph	2011
Treatment of acne with photodynamic therapy. Giornale italiano di dermatologia e venereologia : organo ufficiale, Societa italiana di dermatologia e sifilografia, 2011, Volume: 146, Issue:6 Topics: Acne Vulgaris; Aminolevulinic Acid; Forecasting; Humans; Photochemotherapy; Photosensitizing Agents	2011
Photodynamic therapy: current evidence and applications in dermatology. Seminars in cutaneous medicine and surgery, 2011, Volume: 30, Issue:4 Topics: Acne Vulgaris; Aminolevulinic Acid; Bowen's Disease; Candidiasis; Carcinoma, Basal Cell; Humans; Ker	2011
Topical photodynamic therapy: a new tool in cosmetic dermatology. Seminars in cutaneous medicine and surgery, 2003, Volume: 22, Issue:2 Topics: Acne Vulgaris; Administration, Topical; Aminolevulinic Acid; Hair Removal; Humans; Keratosis; Photoc	2003
5-aminolevulinic acid photodynamic therapy: where we have been and where we are going. Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.], 2004, Volume: 30, Issue:8 Topics: Acne Vulgaris; Administration, Cutaneous; Aminolevulinic Acid; Clinical Trials as Topic; Humans; Ker	2004
A review of lasers and light sources in the treatment of acne vulgaris. Journal of cosmetic and laser therapy : official publication of the European Society for Laser Dermatology, 2005, Volume: 7, Issue:2 Topics: Acne Vulgaris; Aminolevulinic Acid; Dermabrasion; Humans; Laser Therapy; Photochemotherapy; Photosen	2005
Aminolevulinic acid photodynamic therapy for actinic keratoses/actinic cheilitis/acne: vascular lasers. Dermatologic clinics, 2007, Volume: 25, Issue:1 Topics: Acne Vulgaris; Aminolevulinic Acid; Cheilitis; Humans; Keratosis; Low-Level Light Therapy; Photochem	2007
The use of photodynamic therapy for treatment of acne vulgaris. Dermatologic clinics, 2007, Volume: 25, Issue:1 Topics: Acne Vulgaris; Aminolevulinic Acid; Photochemotherapy; Photosensitizing Agents; Sebaceous Glands	2007
Acne and PDT: new techniques with lasers and light sources. Lasers in medical science, 2007, Volume: 22, Issue:2 Topics: Acne Vulgaris; Aminolevulinic Acid; Humans; Indocyanine Green; Low-Level Light Therapy; Photochemoth	2007
Procedural treatments for acne vulgaris. Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.], 2007, Volume: 33, Issue:9 Topics: Acne Vulgaris; Aminolevulinic Acid; Chemexfoliation; Coloring Agents; Cryotherapy; Dermabrasion; Glu	2007
Photodynamic therapy update 2007. Journal of drugs in dermatology : JDD, 2007, Volume: 6, Issue:11 Topics: Acne Vulgaris; Administration, Topical; Aminolevulinic Acid; Animals; Clinical Trials as Topic; Fema	2007
Acne vulgaris: lasers, light sources and photodynamic therapy--an update 2007. Expert review of anti-infective therapy, 2007, Volume: 5, Issue:6 Topics: Acne Vulgaris; Aminolevulinic Acid; Humans; Laser Therapy; Light; Low-Level Light Therapy; Photochem	2007
Topical 5-aminolaevulinic acid photodynamic therapy for the treatment of skin conditions other than non-melanoma skin cancer. The British journal of dermatology, 2002, Volume: 146, Issue:2 Topics: Acne Vulgaris; Aminolevulinic Acid; Humans; Lymphoma, T-Cell; Photochemotherapy; Photosensitizing Ag	2002

Article	Year
Optimizing treatment of acne with photodynamic therapy (PDT) to achieve long-term remission and reduce side effects. A prospective randomized controlled trial. Journal of photochemistry and photobiology. B, Biology, 2021, Volume: 223 Topics: Acne Vulgaris; Adolescent; Adult; Aminolevulinic Acid; Female; Humans; Light; Male; Pain; Photochemo	2021
Modified red light 5-aminolevulinic acid photodynamic therapy versus low-dose isotretinoin therapy for moderate to severe acne vulgaris: A prospective, randomized, multicenter study. Journal of the American Academy of Dermatology, 2023, Volume: 89, Issue:6 Topics: Acne Vulgaris; Aminolevulinic Acid; Humans; Isotretinoin; Photochemotherapy; Photosensitizing Agents	2023
The quantitative analysis of low-concentration (2%) ALA-PDT assisted with Q-switch 1064-nm Nd:YAG laser for acne vulgaris treatment. Lasers in medical science, 2023, Oct-16, Volume: 38, Issue:1 Topics: Acne Vulgaris; Aminolevulinic Acid; Erythema; Humans; Lasers, Solid-State; Melanins; Photochemothera	2023
Randomized controlled double-blind study of a cleanser composed of 5-aminolevulinic acid and peptides on mild and moderate acne vulgaris. Journal of cosmetic dermatology, 2020, Volume: 19, Issue:7 Topics: Acne Vulgaris; Aminolevulinic Acid; Double-Blind Method; Humans; Peptides; Severity of Illness Index	2020
Modified 5-aminolevulinic acid photodynamic therapy to reduce pain in the treatment of moderate to severe acne vulgaris: A prospective, randomized, split-face study. Journal of the American Academy of Dermatology, 2021, Volume: 84, Issue:1 Topics: Acne Vulgaris; Aminolevulinic Acid; Humans; Pain; Photochemotherapy; Photosensitizing Agents; Prospe	2021
Conventional versus daylight photodynamic therapy for acne vulgaris: A randomized and prospective clinical study in China. Photodiagnosis and photodynamic therapy, 2020, Volume: 31 Topics: Acne Vulgaris; Aminolevulinic Acid; China; Humans; Photochemotherapy; Photosensitizing Agents; Prosp	2020
Combination of 5-Aminolevulinic acid photodynamic therapy and isotretinoin to treat moderate-to-severe acne. Photodiagnosis and photodynamic therapy, 2021, Volume: 34 Topics: Acne Vulgaris; Aminolevulinic Acid; China; Humans; Isotretinoin; Photochemotherapy; Photosensitizing	2021
A split-face clinical trial of conventional red-light photodynamic therapy versus daylight photodynamic therapy for acne vulgaris. Journal of cosmetic dermatology, 2021, Volume: 20, Issue:12 Topics: Acne Vulgaris; Aminolevulinic Acid; Humans; Photochemotherapy; Photosensitizing Agents; Prospective	2021
Three-step irradiance schedule versus two-step irradiance schedule for pain control during topical 5-aminolevulinic acid-photodynamic therapy of facial acne in Chinese patients: A prospective randomized comparative study. Lasers in surgery and medicine, 2022, Volume: 54, Issue:2 Topics: Acne Vulgaris; Aminolevulinic Acid; China; Humans; Pain; Photochemotherapy; Photosensitizing Agents;	2022
Nonablative fractional laser-assisted daylight photodynamic therapy with topical methyl aminolevulinate for moderate to severe facial acne vulgaris: Results of a randomized and comparative study. Photodermatology, photoimmunology & photomedicine, 2017, Volume: 33, Issue:5 Topics: Acne Vulgaris; Adult; Aminolevulinic Acid; Female; Humans; Lasers, Solid-State; Male; Photochemother	2017
Comparative study of the bactericidal effects of indocyanine green- and methyl aminolevulinate-based photodynamic therapy on Propionibacterium acnes as a new treatment for acne. The Journal of dermatology, 2018, Volume: 45, Issue:7 Topics: Acne Vulgaris; Adult; Aminolevulinic Acid; Anti-Infective Agents; Colony Count, Microbial; Female; H	2018
The efficacy and tolerability of 5-aminolevulinic acid 5% thermosetting gel photodynamic therapy (PDT) in the treatment of mild-to-moderate acne vulgaris. A two-center, prospective assessor-blinded, proof-of-concept study. Journal of cosmetic dermatology, 2019, Volume: 18, Issue:1 Topics: Acne Vulgaris; Adolescent; Adult; Aminolevulinic Acid; Facial Dermatoses; Female; Gels; Humans; Male	2019
Comparison of efficacy of aminolaevulinic acid photodynamic therapy vs. adapalene gel plus oral doxycycline for treatment of moderate acne vulgaris-A simple, blind, randomized, and controlled trial. Photodermatology, photoimmunology & photomedicine, 2019, Volume: 35, Issue:1 Topics: Acne Vulgaris; Adapalene; Administration, Oral; Adolescent; Adult; Aminolevulinic Acid; Double-Blind	2019
Effectiveness of photodynamic therapy with topical 5-aminolevulinic acid and intense pulsed light in Chinese acne vulgaris patients. Photodermatology, photoimmunology & photomedicine, 2013, Volume: 29, Issue:2 Topics: Acne Vulgaris; Adult; Aminolevulinic Acid; Asian People; China; Female; Follow-Up Studies; Humans; I	2013
Low-dose topical 5-aminolevulinic acid photodynamic therapy in the treatment of different severity of acne vulgaris. Photodiagnosis and photodynamic therapy, 2013, Volume: 10, Issue:4 Topics: Acne Vulgaris; Administration, Topical; Aminolevulinic Acid; China; Dose-Response Relationship, Drug	2013
Combination ALA-PDT and ablative fractional Er:YAG laser (2,940 nm) on the treatment of severe acne. Lasers in surgery and medicine, 2014, Volume: 46, Issue:3 Topics: Acne Vulgaris; Adult; Aminolevulinic Acid; Cicatrix; Combined Modality Therapy; Drug Administration	2014
Daylight photodynamic therapy with 1.5% 3-butenyl 5-aminolevulinate gel as a convenient, effective and safe therapy in acne treatment: A double-blind randomized controlled trial. The Journal of dermatology, 2016, Volume: 43, Issue:5 Topics: Acne Vulgaris; Adult; Aminolevulinic Acid; Double-Blind Method; Esters; Face; Female; Gels; Humans;	2016
Photodynamic therapy with methyl aminolaevulinate 80 mg g(-1) for severe facial acne vulgaris: a randomized vehicle-controlled study. The British journal of dermatology, 2016, Volume: 174, Issue:4 Topics: Acne Vulgaris; Administration, Cutaneous; Adolescent; Adult; Aminolevulinic Acid; Child; Double-Blin	2016
Use of Optical Fiber Imported Intra-Tissue Photodynamic Therapy for Treatment of Moderate to Severe Acne Vulgaris. Medical science monitor : international medical journal of experimental and clinical research, 2016, Feb-03, Volume: 22 Topics: Acne Vulgaris; Aminolevulinic Acid; Case-Control Studies; Follow-Up Studies; Humans; Optical Fibers;	2016
Effects of 5-aminolevulinic acid photodynamic therapy on TLRs in acne lesions and keratinocytes co-cultured with P. acnes. Photodiagnosis and photodynamic therapy, 2016, Volume: 15 Topics: Acne Vulgaris; Adolescent; Adult; Aminolevulinic Acid; Cells, Cultured; Coculture Techniques; Female	2016
Acne-photodynamic therapy with intra-lesional injection of 5-aminolevulinic acid. Photodermatology, photoimmunology & photomedicine, 2009, Volume: 25, Issue:1 Topics: Acne Vulgaris; Adolescent; Adult; Aminolevulinic Acid; Female; Humans; Injections, Intralesional; Ma	2009
A comparative study of topical 5-aminolevulinic acid incubation times in photodynamic therapy with intense pulsed light for the treatment of inflammatory acne. Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.], 2009, Volume: 35, Issue:12 Topics: Acne Vulgaris; Administration, Topical; Adolescent; Adult; Aminolevulinic Acid; Female; Humans; Male	2009
Photodynamic therapy of acne vulgaris using 5-aminolevulinic acid 0.5% liposomal spray and intense pulsed light in combination with topical keratolytic agents. Journal of the European Academy of Dermatology and Venereology : JEADV, 2010, Volume: 24, Issue:4 Topics: Acne Vulgaris; Administration, Topical; Adolescent; Adult; Aminolevulinic Acid; Anti-Bacterial Agent	2010
The effect of aminolevulinic acid photodynamic therapy on microcomedones and macrocomedones. Dermatology (Basel, Switzerland), 2009, Volume: 219, Issue:4 Topics: Acne Vulgaris; Adolescent; Adult; Aminolevulinic Acid; Back; Biopsy; Face; Female; Humans; Male; Pho	2009
Radiant near infrared light emitting Diode exposure as skin preparation to enhance photodynamic therapy inflammatory type acne treatment outcome. Lasers in surgery and medicine, 2010, Volume: 42, Issue:2 Topics: Acne Vulgaris; Administration, Cutaneous; Adolescent; Adult; Aminolevulinic Acid; Confidence Interva	2010
Topical ALA PDT for the treatment of severe acne vulgaris. Photodiagnosis and photodynamic therapy, 2010, Volume: 7, Issue:1 Topics: Acne Vulgaris; Administration, Topical; Adolescent; Adult; Aminolevulinic Acid; Female; Humans; Male	2010
An open-label, split-face study comparing the safety and efficacy of levulan kerastick (aminolevulonic acid) plus a 532 nm KTP laser to a 532 nm KTP laser alone for the treatment of moderate facial acne. Journal of drugs in dermatology : JDD, 2010, Volume: 9, Issue:3 Topics: Acne Vulgaris; Aminolevulinic Acid; Face; Humans; Laser Therapy; Photochemotherapy; Photosensitizing	2010
Photodynamic therapy for acne vulgaris: a randomized, controlled, split-face clinical trial of topical aminolevulinic acid and pulsed dye laser therapy. Journal of cosmetic dermatology, 2010, Volume: 9, Issue:1 Topics: Acne Vulgaris; Administration, Cutaneous; Adolescent; Aminolevulinic Acid; Dermatologic Agents; Fema	2010
Investigation of optimal aminolaevulinic acid concentration applied in topical aminolaevulinic acid-photodynamic therapy for treatment of moderate to severe acne: a pilot study in Chinese subjects. The British journal of dermatology, 2010, Volume: 163, Issue:5 Topics: Acne Vulgaris; Administration, Topical; Adolescent; Adult; Aminolevulinic Acid; Asian People; Dose-R	2010
[Photodynamic therapy for acne: use of the pulsed dye laser and methylaminolevulinate]. Actas dermo-sifiliograficas, 2010, Volume: 101, Issue:9 Topics: Acne Vulgaris; Adolescent; Aminolevulinic Acid; Combined Modality Therapy; Facial Dermatoses; Female	2010
Photodynamic therapy with methylaminolevulinate 80 mg/g without occlusion improves acne vulgaris. Journal of drugs in dermatology : JDD, 2010, Volume: 9, Issue:11 Topics: Acne Vulgaris; Aminolevulinic Acid; Humans; Pain Measurement; Photochemotherapy; Photosensitizing Ag	2010
0.5% Liposome-encapsulated 5-aminolevulinic acid (ALA) photodynamic therapy for acne treatment. Journal of cosmetic and laser therapy : official publication of the European Society for Laser Dermatology, 2011, Volume: 13, Issue:1 Topics: Acne Vulgaris; Administration, Cutaneous; Adult; Aminolevulinic Acid; Female; Humans; Liposomes; Mal	2011
Effect of photodynamic therapy on inflammatory acne using 3% liposomal 5-aminolevulinic acid emulsion and intense-pulsed light: A pilot study. The Journal of dermatology, 2012, Volume: 39, Issue:8 Topics: Acne Vulgaris; Aminolevulinic Acid; Humans; Liposomes; Photochemotherapy; Photosensitizing Agents; P	2012
A retrospective analysis of real-life practice of off-label photodynamic therapy using methyl aminolevulinate (MAL-PDT) in 20 Italian dermatology departments. Part 1: inflammatory and aesthetic indications. Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology, 2013, Volume: 12, Issue:1 Topics: Acne Vulgaris; Adult; Aged; Aged, 80 and over; Aminolevulinic Acid; Female; Humans; Italy; Light; Ma	2013
Acne treatment by methyl aminolevulinate photodynamic therapy with red light vs. intense pulsed light. International journal of dermatology, 2013, Volume: 52, Issue:5 Topics: Acne Vulgaris; Adult; Aminolevulinic Acid; Color; Female; Humans; Intense Pulsed Light Therapy; Male	2013
A single-center study of aminolevulinic acid and 417 NM photodynamic therapy in the treatment of moderate to severe acne vulgaris. Journal of drugs in dermatology : JDD, 2003, Volume: 2, Issue:4 Topics: Acne Vulgaris; Aminolevulinic Acid; Drug Administration Schedule; Humans; Photochemotherapy; Photose	2003
Topical aminolaevulinic acid-photodynamic therapy for the treatment of acne vulgaris: a study of clinical efficacy and mechanism of action. The British journal of dermatology, 2004, Volume: 151, Issue:3 Topics: Acne Vulgaris; Adolescent; Adult; Aminolevulinic Acid; Back; Female; Humans; Male; Photochemotherapy	2004
Delta-aminolevulinic acid-based photodynamic therapy for acne on the body. The Journal of dermatology, 2004, Volume: 31, Issue:12 Topics: Acne Vulgaris; Administration, Oral; Adult; Aminolevulinic Acid; Female; Humans; Male; Photochemothe	2004
Effectiveness of photodynamic therapy with topical 5-aminolevulinic acid and intense pulsed light versus intense pulsed light alone in the treatment of acne vulgaris: comparative study. Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.], 2005, Volume: 31, Issue:8 Pt 1 Topics: Acne Vulgaris; Adult; Aminolevulinic Acid; Female; Humans; Male; Middle Aged; Photochemotherapy; Pho	2005
Long-pulsed dye laser-mediated photodynamic therapy combined with topical therapy for mild to severe comedonal, inflammatory, or cystic acne. Journal of drugs in dermatology : JDD, 2006, Volume: 5, Issue:1 Topics: Acne Vulgaris; Adolescent; Adult; Aminolevulinic Acid; Humans; Laser Therapy; Middle Aged; Photochem	2006
Photodynamic therapy of acne vulgaris using 5-aminolevulinic acid versus methyl aminolevulinate. Journal of the American Academy of Dermatology, 2006, Volume: 54, Issue:4 Topics: Acne Vulgaris; Adolescent; Adult; Aminolevulinic Acid; Double-Blind Method; Humans; Photochemotherap	2006
Photodynamic therapy of acne vulgaris using methyl aminolaevulinate: a blinded, randomized, controlled trial. The British journal of dermatology, 2006, Volume: 154, Issue:5 Topics: Acne Vulgaris; Adult; Aminolevulinic Acid; Double-Blind Method; Female; Humans; Male; Pain; Photoche	2006
Topical methyl aminolaevulinate photodynamic therapy for treatment of facial acne vulgaris: results of a randomized, controlled study. The British journal of dermatology, 2006, Volume: 155, Issue:3 Topics: Acne Vulgaris; Administration, Cutaneous; Adolescent; Adult; Aminolevulinic Acid; Double-Blind Metho	2006
A comparative study of intense pulsed light alone and its combination with photodynamic therapy for the treatment of facial acne in Asian skin. Lasers in surgery and medicine, 2007, Volume: 39, Issue:1 Topics: Acne Vulgaris; Adolescent; Adult; Aminolevulinic Acid; Asian People; Face; Female; Humans; Low-Level	2007
Efficacy of microdermabrasion preceding ALA application in reducing the incubation time of ALA in laser PDT. Journal of drugs in dermatology : JDD, 2007, Volume: 6, Issue:2 Topics: Acne Vulgaris; Administration, Topical; Adult; Aminolevulinic Acid; Erythema; Humans; Keratosis; Las	2007
Photodynamic therapy for acne vulgaris: a pilot study of the dose-response and mechanism of action. Acta dermato-venereologica, 2007, Volume: 87, Issue:4 Topics: Acne Vulgaris; Adolescent; Adult; Aminolevulinic Acid; Female; Humans; Hyperpigmentation; Male; Pain	2007
Photodynamic therapy of acne using methyl aminolaevulinate diluted to 4% together with low doses of red light. The British journal of dermatology, 2007, Volume: 157, Issue:4 Topics: Acne Vulgaris; Adolescent; Adult; Aminolevulinic Acid; Drug Administration Schedule; Female; Follow-	2007
A comparison of intense pulsed light, combination radiofrequency and intense pulsed light, and blue light in photodynamic therapy for acne vulgaris. Journal of drugs in dermatology : JDD, 2007, Volume: 6, Issue:10 Topics: Acne Vulgaris; Administration, Topical; Adolescent; Adult; Aminolevulinic Acid; Female; Humans; Male	2007
Long-pulsed dye laser versus long-pulsed dye laser-assisted photodynamic therapy for acne vulgaris: A randomized controlled trial. Journal of the American Academy of Dermatology, 2008, Volume: 58, Issue:3 Topics: Acne Vulgaris; Adult; Aminolevulinic Acid; Edema; Erythema; Female; Fluorescence; Humans; Laser Ther	2008
Topical ALA-photodynamic therapy for the treatment of acne vulgaris. The Journal of investigative dermatology, 2000, Volume: 115, Issue:2 Topics: Acne Vulgaris; Administration, Topical; Adult; Aminolevulinic Acid; Dermatitis; Drug Administration	2000
Photodynamic therapy of acne vulgaris with topical delta-aminolaevulinic acid and incoherent light in Japanese patients. The British journal of dermatology, 2001, Volume: 144, Issue:3 Topics: Acne Vulgaris; Adolescent; Adult; Aminolevulinic Acid; Female; Follow-Up Studies; Humans; Male; Phot	2001
Photodynamic therapy for severe facial acne vulgaris with 5% 5-aminolevulinic acid vs 10% 5-aminolevulinic acid: A split-face randomized controlled study. Journal of cosmetic dermatology, 2020, Volume: 19, Issue:2 Topics: Acne Vulgaris; Administration, Cutaneous; Adult; Aminolevulinic Acid; Dose-Response Relationship, Dr	2020

Article	Year
5-Aminolaevulinic acid photodynamic therapy suppresses lipid secretion of primary sebocytes through AMPK/SREBP-1 pathway. Photodiagnosis and photodynamic therapy, 2021, Volume: 36 Topics: Acne Vulgaris; Aminolevulinic Acid; AMP-Activated Protein Kinases; Animals; Cricetinae; Humans; Lipi	2021
ALA-PDT and pulsed dye laser combined with oral antiandrogen drug in the treatment of cystic acne in a patient with hyperandrogenism. Photodermatology, photoimmunology & photomedicine, 2022, Volume: 38, Issue:2 Topics: Acne Vulgaris; Aminolevulinic Acid; Androgen Antagonists; Female; Humans; Hyperandrogenism; Lasers,	2022
Modulation of skin microbiome in acne patients by aminolevulinic acid-photodynamic therapy. Photodiagnosis and photodynamic therapy, 2021, Volume: 36 Topics: Acne Vulgaris; Aminolevulinic Acid; Humans; Microbiota; Photochemotherapy; Photosensitizing Agents;	2021
A prospective study of adverse reactions of ALA-PDT for acne vulgaris. Photodiagnosis and photodynamic therapy, 2022, Volume: 38 Topics: Acne Vulgaris; Aminolevulinic Acid; China; Female; Humans; Hyperpigmentation; Male; Pain; Photochemo	2022
A case of 5-aminolevulinic acid photodynamic therapy(ALA-PDT)combined with surgery for the treatment of acne conglobata. Photodiagnosis and photodynamic therapy, 2022, Volume: 39 Topics: Acne Conglobata; Acne Vulgaris; Adult; Aminolevulinic Acid; Humans; Male; Photochemotherapy; Photose	2022
5-aminolevulinic acid-mediated photodynamic therapy (ALA-PDT) for acneform rash induced by erlotinib: A case report. Photodiagnosis and photodynamic therapy, 2022, Volume: 39 Topics: Acne Vulgaris; Aminolevulinic Acid; Carcinoma, Non-Small-Cell Lung; ErbB Receptors; Erlotinib Hydroc	2022
Topical methylene blue nanoformulation for the photodynamic therapy of acne vulgaris. Archives of dermatological research, 2023, Volume: 315, Issue:4 Topics: Acne Vulgaris; Aminolevulinic Acid; Anti-Infective Agents; Humans; Methylene Blue; Photochemotherapy	2023
ALA-PDT augments intense inflammation in the treatment of acne vulgaris by COX2/TREM1 mediated M1 macrophage polarization. Biochemical pharmacology, 2023, Volume: 208 Topics: Acne Vulgaris; Aminolevulinic Acid; Animals; Cyclooxygenase 2; Dinoprostone; Inflammation; Macrophag	2023
Photodynamic therapy treats acne by altering the composition of the skin microbiota. Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI), 2023, Volume: 29, Issue:1 Topics: Acne Vulgaris; Aminolevulinic Acid; Humans; Microbiota; Photochemotherapy; Propionibacterium acnes;	2023
CO Photodermatology, photoimmunology & photomedicine, 2023, Volume: 39, Issue:5 Topics: Acne Vulgaris; Aminolevulinic Acid; Carbon Dioxide; Humans; Lasers; Photochemotherapy; Photosensitiz	2023
Daylight photodynamic therapy with 5-aminolevulinic acid 5% gel for the treatment of mild-to-moderate inflammatory acne. Italian journal of dermatology and venereology, 2021, Volume: 156, Issue:1 Topics: Acne Vulgaris; Adolescent; Aminolevulinic Acid; Face; Humans; Photochemotherapy; Photosensitizing Ag	2021
5-Aminolevulinic acid photodynamic therapy and isotretinoin for treatment of drug-induced acne fulminans in a patient with idiopathic thrombocytopenic purpura. Photodiagnosis and photodynamic therapy, 2020, Volume: 29 Topics: Acne Vulgaris; Administration, Oral; Adult; Aminolevulinic Acid; Danazol; Drug Therapy, Combination;	2020
Thermomechanical Ablation-Assisted Photodynamic Therapy for the Treatment of Acne Vulgaris. A Retrospective Chart Review of 30 Patients. Lasers in surgery and medicine, 2020, Volume: 52, Issue:10 Topics: Acne Vulgaris; Adolescent; Aminolevulinic Acid; Humans; Photochemotherapy; Photosensitizing Agents;	2020
The effects of ALA-PDT on microbiota in pilosebaceous units of patients with severe acne: A metagenomic study. Photodiagnosis and photodynamic therapy, 2021, Volume: 33 Topics: Acne Vulgaris; Aminolevulinic Acid; Humans; Longitudinal Studies; Microbiota; Photochemotherapy; Pho	2021
A massive mandibular keloid with severe infection: What is your treatment? Photodiagnosis and photodynamic therapy, 2021, Volume: 33 Topics: Acne Vulgaris; Aminolevulinic Acid; Humans; Keloid; Photochemotherapy; Photosensitizing Agents; Trea	2021
The assessment of psychology, quality of life in acne patients and evaluation of ALA-PDT for moderate to severe acne. Photodiagnosis and photodynamic therapy, 2021, Volume: 33 Topics: Acne Vulgaris; Aminolevulinic Acid; Humans; Photochemotherapy; Photosensitizing Agents; Quality of L	2021
Hexyl-aminolevulinate ethosome-mediated photodynamic therapy against acne: in vitro and in vivo analyses. Drug delivery and translational research, 2022, Volume: 12, Issue:1 Topics: Acne Vulgaris; Aminolevulinic Acid; Animals; Photochemotherapy; Photosensitizing Agents; Rats; Rats,	2022
Two-step irradiance provides less pain with similar efficacy in photodynamic therapy on chinese patients with moderate to severe acne. Photodermatology, photoimmunology & photomedicine, 2021, Volume: 37, Issue:6 Topics: Acne Vulgaris; Aminolevulinic Acid; China; Humans; Pain; Photochemotherapy; Photosensitizing Agents;	2021
A clinical study of carbon dioxide lattice laser-assisted or microneedle-assisted 5-aminolevulinic acid-based photodynamic therapy for the treatment of hypertrophic acne scars. Photodermatology, photoimmunology & photomedicine, 2022, Volume: 38, Issue:1 Topics: Acne Vulgaris; Aminolevulinic Acid; Carbon Dioxide; Cicatrix, Hypertrophic; Humans; Lasers, Gas; Pho	2022
Severe acne in monozygotic twins treated with photodynamic therapy. Photodiagnosis and photodynamic therapy, 2018, Volume: 23 Topics: Acne Vulgaris; Adolescent; Aminolevulinic Acid; Humans; Male; Photochemotherapy; Photosensitizing Ag	2018
What is the most relevent factor causing pain during ALA-PDT? A multi-center, open clinical pain score research trial of actinic keratosis, acne and condylomata acuminata. Photodiagnosis and photodynamic therapy, 2019, Volume: 26 Topics: Acne Vulgaris; Adult; Aminolevulinic Acid; Condylomata Acuminata; Dermoscopy; Facial Dermatoses; Fem	2019
Prospective study of topical 5-aminolevulinic acid photodynamic therapy for the treatment of severe adolescent acne in Chinese patients. The Journal of dermatology, 2015, Volume: 42, Issue:5 Topics: Acne Vulgaris; Adolescent; Aminolevulinic Acid; Child; China; Female; Humans; Male; Photochemotherap	2015
Short-contact, low-dose methyl aminolaevulinate photodynamic therapy for acne vulgaris. The British journal of dermatology, 2016, Volume: 175, Issue:1 Topics: Acne Vulgaris; Aminolevulinic Acid; Facial Dermatoses; Female; Humans; Male; Photochemotherapy; Phot	2016
Efficacy of 3.6% topical ALA-PDT for the treatment of severe acne vulgaris. European review for medical and pharmacological sciences, 2016, Volume: 20, Issue:2 Topics: Acne Vulgaris; Administration, Cutaneous; Adolescent; Adult; Aminolevulinic Acid; Female; Humans; Ma	2016
Photodynamic therapy for acne: are we there yet? The British journal of dermatology, 2016, Volume: 174, Issue:4 Topics: Acne Vulgaris; Aminolevulinic Acid; Humans; Photochemotherapy; Photosensitizing Agents	2016
Low-Dose Topical 5-Aminolevulinic Acid Photodynamic Therapy in the Treatment of Different Severity of Acne Vulgaris. Cell biochemistry and biophysics, 2015, Volume: 73, Issue:3 Topics: Acne Vulgaris; Administration, Topical; Adolescent; Adult; Aminolevulinic Acid; Female; Humans; Male	2015
Utilizing non-ablative fractional photothermolysis prior to ALA-photodynamic therapy in the treatment of acne vulgaris: a case series. Lasers in medical science, 2017, Volume: 32, Issue:3 Topics: Acne Vulgaris; Adult; Aminolevulinic Acid; Combined Modality Therapy; Female; Humans; Lasers; Male;	2017
Photodynamic therapy with low-strength ALA, repeated applications and short contact periods (40-60 minutes) in acne, photoaging and vitiligo. Journal of drugs in dermatology : JDD, 2009, Volume: 8, Issue:6 Topics: Acne Vulgaris; Administration, Topical; Adolescent; Adult; Aminolevulinic Acid; Drug Administration	2009
Treatment of acne vulgaris using blue light photodynamic therapy in an African-American patient. Journal of drugs in dermatology : JDD, 2009, Volume: 8, Issue:7 Topics: Acne Vulgaris; Adult; Aminolevulinic Acid; Black or African American; Female; Humans; Hydroquinones;	2009
Single low-dose red light is as efficacious as methyl-aminolevulinate--photodynamic therapy for treatment of acne: clinical assessment and fluorescence monitoring. Acta dermato-venereologica, 2009, Volume: 89, Issue:4 Topics: Acne Vulgaris; Administration, Topical; Adult; Aminolevulinic Acid; Female; Humans; Male; Photochemo	2009
Photosensitization induced by exposure to colour cathode ray tube monitor following topical 5-aminolaevulinic acid-based photodynamic therapy: a case report. Acta dermato-venereologica, 2010, Volume: 90, Issue:5 Topics: Acne Vulgaris; Administration, Topical; Adult; Aminolevulinic Acid; Cathode Ray Tube; Computer Termi	2010
Comparative study of the bactericidal effects of 5-aminolevulinic acid with blue and red light on Propionibacterium acnes. The Journal of dermatology, 2011, Volume: 38, Issue:7 Topics: Acne Vulgaris; Aminolevulinic Acid; Anti-Bacterial Agents; Coproporphyrins; Gram-Positive Bacterial	2011
Liposome-encapsulated 0.5% 5-aminolevulinic acid with intense pulsed light for the treatment of inflammatory facial acne: a pilot study. Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.], 2011, Volume: 37, Issue:4 Topics: Acne Vulgaris; Adult; Aminolevulinic Acid; Asian People; Dose-Response Relationship, Drug; Female; F	2011
Commentary: how do we achieve consistent reproducible and clinically relevant results with PDT for acne? Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.], 2011, Volume: 37, Issue:4 Topics: Acne Vulgaris; Aminolevulinic Acid; Humans; Liposomes; Photochemotherapy; Photosensitizing Agents; R	2011
[Therapeutic effect of photodynamic treatment for psoriasis vulgaris in guinea pigs]. Nan fang yi ke da xue xue bao = Journal of Southern Medical University, 2011, Volume: 31, Issue:5 Topics: Acne Vulgaris; Aminolevulinic Acid; Animals; Guinea Pigs; Photochemotherapy; Photosensitizing Agents	2011
Targeting of sebaceous glands by δ-aminolevulinic acid-based photodynamic therapy: An in vivo study. Lasers in surgery and medicine, 2011, Volume: 43, Issue:5 Topics: Acne Vulgaris; Aminolevulinic Acid; Animals; Disease Models, Animal; Dose-Response Relationship, Dru	2011
Successful treatment of refractory facial acne using repeat short-cycle ALA-PDT: Case study. Photodiagnosis and photodynamic therapy, 2011, Volume: 8, Issue:4 Topics: Acne Vulgaris; Aminolevulinic Acid; Chronic Disease; Facial Dermatoses; Humans; Male; Photochemother	2011
Eradication of Propionibacterium acnes by its endogenic porphyrins after illumination with high intensity blue light. FEMS immunology and medical microbiology, 2003, Jan-21, Volume: 35, Issue:1 Topics: Acne Vulgaris; Aminolevulinic Acid; Chromatography, High Pressure Liquid; Coproporphyrins; Culture M	2003
Eradication of Propionibacterium acnes by its endogenic porphyrins after illumination with high intensity blue light. FEMS immunology and medical microbiology, 2003, Jan-21, Volume: 35, Issue:1 Topics: Acne Vulgaris; Aminolevulinic Acid; Chromatography, High Pressure Liquid; Coproporphyrins; Culture M	2003
Eradication of Propionibacterium acnes by its endogenic porphyrins after illumination with high intensity blue light. FEMS immunology and medical microbiology, 2003, Jan-21, Volume: 35, Issue:1 Topics: Acne Vulgaris; Aminolevulinic Acid; Chromatography, High Pressure Liquid; Coproporphyrins; Culture M	2003
Eradication of Propionibacterium acnes by its endogenic porphyrins after illumination with high intensity blue light. FEMS immunology and medical microbiology, 2003, Jan-21, Volume: 35, Issue:1 Topics: Acne Vulgaris; Aminolevulinic Acid; Chromatography, High Pressure Liquid; Coproporphyrins; Culture M	2003
Eradication of Propionibacterium acnes by its endogenic porphyrins after illumination with high intensity blue light. FEMS immunology and medical microbiology, 2003, Jan-21, Volume: 35, Issue:1 Topics: Acne Vulgaris; Aminolevulinic Acid; Chromatography, High Pressure Liquid; Coproporphyrins; Culture M	2003
Eradication of Propionibacterium acnes by its endogenic porphyrins after illumination with high intensity blue light. FEMS immunology and medical microbiology, 2003, Jan-21, Volume: 35, Issue:1 Topics: Acne Vulgaris; Aminolevulinic Acid; Chromatography, High Pressure Liquid; Coproporphyrins; Culture M	2003
Eradication of Propionibacterium acnes by its endogenic porphyrins after illumination with high intensity blue light. FEMS immunology and medical microbiology, 2003, Jan-21, Volume: 35, Issue:1 Topics: Acne Vulgaris; Aminolevulinic Acid; Chromatography, High Pressure Liquid; Coproporphyrins; Culture M	2003
Eradication of Propionibacterium acnes by its endogenic porphyrins after illumination with high intensity blue light. FEMS immunology and medical microbiology, 2003, Jan-21, Volume: 35, Issue:1 Topics: Acne Vulgaris; Aminolevulinic Acid; Chromatography, High Pressure Liquid; Coproporphyrins; Culture M	2003
Eradication of Propionibacterium acnes by its endogenic porphyrins after illumination with high intensity blue light. FEMS immunology and medical microbiology, 2003, Jan-21, Volume: 35, Issue:1 Topics: Acne Vulgaris; Aminolevulinic Acid; Chromatography, High Pressure Liquid; Coproporphyrins; Culture M	2003
Eradication of Propionibacterium acnes by its endogenic porphyrins after illumination with high intensity blue light. FEMS immunology and medical microbiology, 2003, Jan-21, Volume: 35, Issue:1 Topics: Acne Vulgaris; Aminolevulinic Acid; Chromatography, High Pressure Liquid; Coproporphyrins; Culture M	2003
Eradication of Propionibacterium acnes by its endogenic porphyrins after illumination with high intensity blue light. FEMS immunology and medical microbiology, 2003, Jan-21, Volume: 35, Issue:1 Topics: Acne Vulgaris; Aminolevulinic Acid; Chromatography, High Pressure Liquid; Coproporphyrins; Culture M	2003
Eradication of Propionibacterium acnes by its endogenic porphyrins after illumination with high intensity blue light. FEMS immunology and medical microbiology, 2003, Jan-21, Volume: 35, Issue:1 Topics: Acne Vulgaris; Aminolevulinic Acid; Chromatography, High Pressure Liquid; Coproporphyrins; Culture M	2003
Eradication of Propionibacterium acnes by its endogenic porphyrins after illumination with high intensity blue light. FEMS immunology and medical microbiology, 2003, Jan-21, Volume: 35, Issue:1 Topics: Acne Vulgaris; Aminolevulinic Acid; Chromatography, High Pressure Liquid; Coproporphyrins; Culture M	2003
Eradication of Propionibacterium acnes by its endogenic porphyrins after illumination with high intensity blue light. FEMS immunology and medical microbiology, 2003, Jan-21, Volume: 35, Issue:1 Topics: Acne Vulgaris; Aminolevulinic Acid; Chromatography, High Pressure Liquid; Coproporphyrins; Culture M	2003
Eradication of Propionibacterium acnes by its endogenic porphyrins after illumination with high intensity blue light. FEMS immunology and medical microbiology, 2003, Jan-21, Volume: 35, Issue:1 Topics: Acne Vulgaris; Aminolevulinic Acid; Chromatography, High Pressure Liquid; Coproporphyrins; Culture M	2003
Eradication of Propionibacterium acnes by its endogenic porphyrins after illumination with high intensity blue light. FEMS immunology and medical microbiology, 2003, Jan-21, Volume: 35, Issue:1 Topics: Acne Vulgaris; Aminolevulinic Acid; Chromatography, High Pressure Liquid; Coproporphyrins; Culture M	2003
Topical aminolevulinic acid-photodynamic therapy for the treatment of acne vulgaris. Photodermatology, photoimmunology & photomedicine, 2005, Volume: 21, Issue:6 Topics: Acne Vulgaris; Administration, Topical; Adolescent; Adult; Aminolevulinic Acid; Female; Humans; Male	2005
Implementing photodynamic therapy. Journal of drugs in dermatology : JDD, 2006, Volume: 5, Issue:2 Suppl Topics: Acne Vulgaris; Aminolevulinic Acid; Attitude to Health; Humans; Keratosis; Photochemotherapy; Photos	2006
Henry Ford Hospital dermatology experience with Levulan Kerastick and blue light photodynamic therapy. Journal of drugs in dermatology : JDD, 2006, Volume: 5, Issue:6 Topics: Acne Vulgaris; Adult; Aminolevulinic Acid; Female; Hidradenitis Suppurativa; Humans; Keratosis; Male	2006
Treatment of inflammatory facial acne vulgaris with intense pulsed light and short contact of topical 5-aminolevulinic acid: a pilot study. Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.], 2006, Volume: 32, Issue:8 Topics: Acne Vulgaris; Administration, Topical; Adolescent; Adult; Aminolevulinic Acid; Face; Female; Humans	2006
Treatment of moderate to severe inflammatory acne vulgaris: photodynamic therapy with 5-aminolevulinic acid and a novel advanced fluorescence technology pulsed light source. Journal of drugs in dermatology : JDD, 2007, Volume: 6, Issue:3 Topics: Acne Vulgaris; Adult; Aminolevulinic Acid; Face; Female; Fluorescence; Humans; Light; Middle Aged; P	2007
Safe usage of isotretinoin in a woman with latent acute intermittent porphyria. Acta dermato-venereologica, 2007, Volume: 87, Issue:3 Topics: Acne Vulgaris; Adult; Aminolevulinic Acid; Dermatologic Agents; Female; Humans; Isotretinoin; Porpho	2007
Efficacy of ALA-PDT vs blue light in the treatment of acne. Photodermatology, photoimmunology & photomedicine, 2007, Volume: 23, Issue:5 Topics: Acne Vulgaris; Adult; Aminolevulinic Acid; Analysis of Variance; Female; Humans; Male; Photochemothe	2007
5-Aminolevulinic acid photodynamic therapy versus methyl aminolevulinate photodynamic therapy for inflammatory acne vulgaris. Journal of the American Academy of Dermatology, 2008, Volume: 58, Issue:2 Suppl Topics: Acne Vulgaris; Aminolevulinic Acid; Humans; Photochemotherapy; Photosensitizing Agents	2008
A health survey of workers in the pentachlorophenol section of a chemical manufacturing plant. American journal of industrial medicine, 1993, Volume: 24, Issue:1 Topics: Acne Vulgaris; Aminolevulinic Acid; Chemical Industry; China; Chlorobenzenes; Health Surveys; Humans	1993
Photodynamic therapy for acne vulgaris with topical 5-aminolevulinic acid. Archives of dermatology, 2000, Volume: 136, Issue:9 Topics: Acne Vulgaris; Adult; Aminolevulinic Acid; Chemexfoliation; Combined Modality Therapy; Female; Human	2000
Some articles should just not be published. Archives of dermatology, 2001, Volume: 137, Issue:7 Topics: Acne Vulgaris; Administration, Topical; Aminolevulinic Acid; Female; Health Care Costs; Humans; Phot	2001
5-Aminolaevulinic acid photodynamic therapy amplifies intense inflammatory response in the treatment of acne vulgaris via CXCL8. Experimental dermatology, 2021, Volume: 30, Issue:7 Topics: Acne Vulgaris; Aminolevulinic Acid; Enzyme-Linked Immunosorbent Assay; Humans; Interleukin-8; Levuli	2021

aminolevulinic acid and Acne

Research Excerpts

Research

Studies (122)

Authors

Clinical Trials (4)

Trial Overview

Trial Outcomes

Global Face Closed Comedones Count - Week 12

Global Face Closed Comedones Count - Week 2

Global Face Closed Comedones Count - Week 4

Global Face Closed Comedones Count - Week 8

Global Face Inflammatory Lesion Count - Week 12

Global Face Inflammatory Lesion Count - Week 2

Global Face Inflammatory Lesion Count - Week 4

Global Face Inflammatory Lesion Count - Week 8

Global Face Non-Inflammatory Lesion Count - Week 12

Global Face Non-Inflammatory Lesion Count - Week 2

Global Face Non-Inflammatory Lesion Count - Week 4

Global Face Non-Inflammatory Lesion Count - Week 8

Global Face Open Comedones Count - Week 12

Global Face Open Comedones Count - Week 2

Global Face Open Comedones Count - Week 4

Global Face Open Comedones Count - Week 8

Global Face Total Lesion Count - Percent Change - Baseline to Week 12

Global Face Total Lesion Count - Percent Change - Baseline to Week 2

Global Face Total Lesion Count - Percent Change - Baseline to Week 4

Global Face Total Lesion Count - Percent Change - Baseline to Week 8

Global Face Total Lesion Count - Percent Change From Baseline to the Mean of All Visits

Global Face Total Lesion Count - Percent Change From Baseline to the Mean of Week 2 and Week 4

Global Face Total Lesion Count - Percent Change From Baseline to the Mean of Week 4 and Week 8

Global Face Total Lesion Count - Percent Change From Baseline to the Mean of Week 8 and Week 12

Global Face Total Lesion Count - Week 12

Global Face Total Lesion Count - Week 2

Global Face Total Lesion Count - Week 4

Global Face Total Lesion Count - Week 8

Investigator Global Acne Assessment - Week 1

Investigator Global Acne Assessment - Week 12

Investigator Global Acne Assessment - Week 2

Investigator Global Acne Assessment - Week 4

Investigator Global Acne Assessment - Week 8

Overall Redness of Inflammatory Lesions - Week 1

Overall Redness of Inflammatory Lesions - Week 12

Overall Redness of Inflammatory Lesions - Week 2

Overall Redness of Inflammatory Lesions - Week 4

Overall Redness of Inflammatory Lesions - Week 8

Overall Size of Inflammatory Lesions - Week 1

Overall Size of Inflammatory Lesions - Week 12

Overall Size of Inflammatory Lesions - Week 2

Overall Size of Inflammatory Lesions - Week 4

Overall Size of Inflammatory Lesions - Week 8

Acne Lesion Counts Total Global Face - Baseline

Acne Lesion Counts Total Global Face - Week 1

Acne Lesion Counts Total Global Face - Week 12

Acne Lesion Counts Total Global Face - Week 2

Acne Lesion Counts Total Global Face - Week 4

Acne Lesion Counts Total Global Face - Week 8

Investigator Global Acne Assessment - Baseline

Investigator Global Acne Assessment - Week 1

Investigator Global Acne Assessment - Week 12

Investigator Global Acne Assessment - Week 2

Investigator Global Acne Assessment - Week 4

Investigator Global Acne Assessment - Week 8

Percent Change of Global Face Total Acne Lesion Count From Baseline

Percent Change of Global Face Total Acne Lesion Count From Baseline to Week 1

Percent Change of Global Face Total Acne Lesion Count From Baseline to Week 2

Percent Change of Global Face Total Acne Lesion Count From Baseline to Week 4

Percent Change of Global Face Total Acne Lesion Count From Baseline to Week 8

Reviews

Trials

Other Studies