aminoindanol and Hepatitis-B

aminoindanol has been researched along with Hepatitis-B* in 1 studies

Other Studies

1 other study(ies) available for aminoindanol and Hepatitis-B

Article	Year
Synthesis and biological evaluation of novel homochiral carbocyclic nucleosides from 1-amino-2-indanols. Bioorganic & medicinal chemistry, 2012, Oct-01, Volume: 20, Issue:19 New chiral purinyl and 8-azapurinyl carbanucleoside derivatives based on indanol were synthesized from commercial available (1S,2S)-trans-1-amino-2-indanol and (1R,2R)-trans-1-amino-2-indanol using a linear methodology. The antiviral activity and cytotoxicity of these compounds were evaluated against herpes simplex virus type 1 (HSV-1) in Vero cells, bovine viral diarrhea virus (BVDV) in Mardin-Darby bovine kidney (MDBK) cells and hepatitis B virus (HBV) in HepG2 2.2.15 cell line. Three compounds, showed an inhibition of the HBsAg levels similar to reference drug lamivudine. One chloropurinyl nucleoside, derived from the cis-1-amino-2-indanol, was cytotoxic on MDBK cells and it could be a lead for developing anticancer agents. Topics: Animals; Antiviral Agents; Bovine Virus Diarrhea-Mucosal Disease; Cattle; Cell Line; Chlorocebus aethiops; Diarrhea Viruses, Bovine Viral; Dogs; Hep G2 Cells; Hepatitis B; Hepatitis B virus; Herpes Simplex; Herpesvirus 1, Human; Humans; Indans; Nucleosides; Stereoisomerism; Vero Cells	2012

Article

Year

Synthesis and biological evaluation of novel homochiral carbocyclic nucleosides from 1-amino-2-indanols.

Bioorganic & medicinal chemistry, 2012, Oct-01, Volume: 20, Issue:19

New chiral purinyl and 8-azapurinyl carbanucleoside derivatives based on indanol were synthesized from commercial available (1S,2S)-trans-1-amino-2-indanol and (1R,2R)-trans-1-amino-2-indanol using a linear methodology. The antiviral activity and cytotoxicity of these compounds were evaluated against herpes simplex virus type 1 (HSV-1) in Vero cells, bovine viral diarrhea virus (BVDV) in Mardin-Darby bovine kidney (MDBK) cells and hepatitis B virus (HBV) in HepG2 2.2.15 cell line. Three compounds, showed an inhibition of the HBsAg levels similar to reference drug lamivudine. One chloropurinyl nucleoside, derived from the cis-1-amino-2-indanol, was cytotoxic on MDBK cells and it could be a lead for developing anticancer agents.

Topics: Animals; Antiviral Agents; Bovine Virus Diarrhea-Mucosal Disease; Cattle; Cell Line; Chlorocebus aethiops; Diarrhea Viruses, Bovine Viral; Dogs; Hep G2 Cells; Hepatitis B; Hepatitis B virus; Herpes Simplex; Herpesvirus 1, Human; Humans; Indans; Nucleosides; Stereoisomerism; Vero Cells

2012