aminoimidazole carboxamide has been researched along with Neoplasms in 28 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (10.71) | 18.7374 |
| 1990's | 1 (3.57) | 18.2507 |
| 2000's | 8 (28.57) | 29.6817 |
| 2010's | 15 (53.57) | 24.3611 |
| 2020's | 1 (3.57) | 2.80 |
| Authors | Studies |
|---|---|
| Jiang, P; Li, G; Li, L; Wu, J | 1 |
| Alaoui, S; Auberger, P; Benhida, R; Bougrin, K; Demange, L; Driowya, M; Dufies, M; Pagès, G; Robert, G | 1 |
| Chibalin, AV; Dolinar, K; Jan, V; Pavlin, M; Pirkmajer, S | 1 |
| Blagih, J; Coelho, PP; Griss, T; Jones, RG; Vincent, EE; Viollet, B | 1 |
| Chatterjee, A; Foster, DA; Kogan, D; Mukhopadhyay, S; Patel, D | 1 |
| Daglioglu, C; Okutucu, B | 1 |
| Jellinek, M | 1 |
| Fernández-Real, JM; Menendez, JA; Oliveras-Ferraros, C; Vazquez-Martin, A | 1 |
| Kim, EJ; Lee, SW; Lee, YG; Sin, HS; Um, SJ | 1 |
| Bi, ZG; He, L; He, SH; Ji, C; Miao, DS; Yang, B; Yang, YL | 1 |
| Armand, JP; Brendel, E; Lathia, C; Ludwig, M; Robert, C; Ropert, S; Soria, JC | 1 |
| Amon, A; Siegel, JJ; Tang, YC; Williams, BR | 1 |
| Bouscary, D; Chapuis, N; Green, AS; Lacombe, C; Mayeux, P; Tamburini, J | 1 |
| Bellance, N; Hébert-Chatelain, E; Jose, C; Larendra, A; Nouette-Gaulain, K; Rossignol, R; Su, M | 1 |
| Ahn, HW; Ahn, YH; Cho, YJ; Choi, KY; Hong, SH | 1 |
| Keller, KE; Lee, YS; Tan, IS | 1 |
| Lopes, IC; Oliveira, SC; Oliveira-Brett, AM | 1 |
| Siegelin, MD | 1 |
| CONZELMAN, GM; MANDEL, HG; SMITH, PK | 2 |
| CARLO, P; MANDEL, HG | 1 |
| Altieri, DC; Colombo, G; Curto, M; Daidone, MG; Meli, M; Pennati, M; Plescia, J; Toba, S; Zaffaroni, N | 1 |
| Hardie, DG; Towler, MC | 1 |
| Carvalheira, JB; de Souza, CT; Faria, MC; Morari, J; Pauli, JR; Ropelle, ER; Saad, MJ; Ueno, M; Velloso, LA; Zecchin, KG | 1 |
| Dynlacht, BD | 1 |
| Hallstrom, TC; Mori, S; Nevins, JR | 1 |
| Alton, K; Baker, SD; Batra, V; Cutler, D; Donehower, RC; Dugan, M; Grochow, LB; Reidenberg, P; Rowinsky, EK; Sartorius, SE; Statkevich, P; Wirth, M | 1 |
3 review(s) available for aminoimidazole carboxamide and Neoplasms
| Article | Year |
|---|---|
LKB1/AMPK/mTOR signaling pathway in hematological malignancies: from metabolism to cancer cell biology.
Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinase Kinases; AMP-Activated Protein Kinases; Hematologic Neoplasms; Humans; Hypoglycemic Agents; Metformin; Neoplasms; Protein Serine-Threonine Kinases; Ribonucleotides; Signal Transduction; TOR Serine-Threonine Kinases | 2011 |
Inhibition of the mitochondrial Hsp90 chaperone network: a novel, efficient treatment strategy for cancer?
Topics: Aminoimidazole Carboxamide; Animals; Antineoplastic Agents; Autophagy; Benzoquinones; Cyclophilins; HSP90 Heat-Shock Proteins; Humans; Lactams, Macrocyclic; Mitochondria; Molecular Chaperones; Molecular Targeted Therapy; Neoplasms; Peptide Fragments; Ribonucleotides; Signal Transduction; TOR Serine-Threonine Kinases | 2013 |
AMP-activated protein kinase in metabolic control and insulin signaling.
Topics: Adenosine Monophosphate; Adenosine Triphosphate; Adipocytes; Amino Acid Sequence; Aminoimidazole Carboxamide; AMP-Activated Protein Kinase Kinases; AMP-Activated Protein Kinases; Animals; Binding Sites; Calcium; Calcium-Calmodulin-Dependent Protein Kinase Kinase; Carbohydrate Metabolism; Cell Cycle; Consensus Sequence; Diabetes Mellitus; Energy Metabolism; Enzyme Activation; Hepatocytes; Humans; Hypoglycemic Agents; Insulin; Lipid Metabolism; Metformin; Mice; Mice, Knockout; Models, Molecular; Molecular Sequence Data; Multienzyme Complexes; Muscle Cells; Neoplasms; Obesity; Oxygen Consumption; Peptide Hormones; Phosphorylation; Protein Processing, Post-Translational; Protein Serine-Threonine Kinases; Protein Subunits; Rats; Ribonucleotides; Sequence Alignment; Sequence Homology, Amino Acid | 2007 |
2 trial(s) available for aminoimidazole carboxamide and Neoplasms
| Article | Year |
|---|---|
Pharmacokinetic results of a phase I trial of sorafenib in combination with dacarbazine in patients with advanced solid tumors.
Topics: Aminoimidazole Carboxamide; Antineoplastic Combined Chemotherapy Protocols; Benzenesulfonates; Dacarbazine; Disease Progression; Female; Humans; Male; Neoplasms; Niacinamide; Phenylurea Compounds; Protein Kinase Inhibitors; Pyridines; Sorafenib | 2011 |
Absorption, metabolism, and excretion of 14C-temozolomide following oral administration to patients with advanced cancer.
Topics: Absorption; Administration, Oral; Adult; Aged; Aminoimidazole Carboxamide; Antineoplastic Agents, Alkylating; Blood Proteins; Carbon Radioisotopes; Dacarbazine; Female; Humans; Male; Metabolic Clearance Rate; Middle Aged; Neoplasms; Temozolomide | 1999 |
23 other study(ies) available for aminoimidazole carboxamide and Neoplasms
| Article | Year |
|---|---|
p53 deficiency induces MTHFD2 transcription to promote cell proliferation and restrain DNA damage.
Topics: Adenylate Kinase; Aminohydrolases; Aminoimidazole Carboxamide; Carbon; Cell Cycle Proteins; Cell Proliferation; Cell Respiration; Cell Survival; Cyclin-Dependent Kinase Inhibitor p21; DNA Damage; DNA End-Joining Repair; Gene Expression Regulation, Neoplastic; HCT116 Cells; Humans; Methylenetetrahydrofolate Dehydrogenase (NADP); Mitochondria; Multifunctional Enzymes; Mutation; Neoplasms; Poly(ADP-ribose) Polymerases; Protein Binding; Ribonucleotides; Signal Transduction; Transcription, Genetic; Tumor Suppressor Protein p53 | 2021 |
Synthesis and anti-cancer activities of new sulfonamides 4-substituted-triazolyl nucleosides.
Topics: Aminoimidazole Carboxamide; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cycloaddition Reaction; Humans; Neoplasms; Nucleosides; Ribonucleotides; Sulfonamides; Triazoles | 2017 |
Nucleosides block AICAR-stimulated activation of AMPK in skeletal muscle and cancer cells.
Topics: Adenosine; Aminoimidazole Carboxamide; AMP-Activated Protein Kinase Kinases; Ascorbic Acid; Cell Line, Tumor; Culture Media; Diabetes Mellitus, Type 2; Energy Metabolism; Glucose; Humans; Muscle, Skeletal; Neoplasms; Nucleosides; Protein Kinases; Ribonucleotides; Thioctic Acid; Vitamin B 12 | 2018 |
SAICAR binding activates PKM2 protein kinase activity.
Topics: Aminoimidazole Carboxamide; Carrier Proteins; Cell Cycle; Cell Proliferation; Humans; Membrane Proteins; Neoplasms; Phosphorylation; Ribonucleotides; Signal Transduction; Thyroid Hormone-Binding Proteins; Thyroid Hormones | 2014 |
Differential effects of AMPK agonists on cell growth and metabolism.
Topics: Adenylate Kinase; Aminoimidazole Carboxamide; Animals; Biphenyl Compounds; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Glucose; HCT116 Cells; HEK293 Cells; Humans; Hypoglycemic Agents; Lactic Acid; Metformin; Mice; Neoplasms; Phenformin; Pyrones; Ribonucleotides; Sodium Salicylate; Thiophenes | 2015 |
5-Aminoimidazole-4-carboxamide-1-β-4-ribofuranoside (AICAR) enhances the efficacy of rapamycin in human cancer cells.
Topics: Aminoimidazole Carboxamide; Antibiotics, Antineoplastic; Cell Cycle Checkpoints; Cell Proliferation; Dose-Response Relationship, Drug; Drug Therapy, Combination; Humans; MCF-7 Cells; Neoplasms; Ribonucleotides; Sirolimus; Treatment Outcome | 2015 |
Synthesis and Characterization of AICAR and DOX Conjugated Multifunctional Nanoparticles as a Platform for Synergistic Inhibition of Cancer Cell Growth.
Topics: Aminoimidazole Carboxamide; Cell Division; Doxorubicin; HeLa Cells; Humans; Nanoparticles; Neoplasms; Ribonucleotides | 2016 |
The need for a multi-level biochemical approach to defeat cancer that will also support the host.
Topics: Adenylate Kinase; Aminoimidazole Carboxamide; Enzyme Activation; Homeostasis; Humans; Models, Theoretical; Neoplasms; Phosphatidylinositol 3-Kinases; Phosphorylation; Ribonucleosides; Uridine Triphosphate | 2008 |
AMPK-sensed cellular energy state regulates the release of extracellular Fatty Acid Synthase.
Topics: Adenosine Monophosphate; Adenosine Triphosphate; Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Antibodies, Monoclonal; Cell Line, Tumor; Culture Media, Conditioned; Cytosol; Energy Metabolism; Fatty Acid Synthase, Type I; Humans; Isoenzymes; Neoplasms; Ribonucleotides; RNA, Small Interfering | 2009 |
Kinase activity-independent suppression of p73alpha by AMP-activated kinase alpha (AMPKalpha).
Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Antineoplastic Agents; Apoptosis; Cell Proliferation; Chromatin Immunoprecipitation; Cisplatin; Cyclin-Dependent Kinase Inhibitor p21; DNA-Binding Proteins; Gene Library; Glutathione Transferase; HeLa Cells; Humans; Luciferases; Microscopy, Fluorescence; Neoplasms; Nuclear Proteins; Phosphorylation; Promoter Regions, Genetic; Protein Binding; Ribonucleosides; RNA, Small Interfering; Transfection; Tumor Cells, Cultured; Tumor Protein p73; Tumor Suppressor Protein p53; Tumor Suppressor Proteins; Two-Hybrid System Techniques | 2009 |
Exogenous cell-permeable C6 ceramide sensitizes multiple cancer cell lines to Doxorubicin-induced apoptosis by promoting AMPK activation and mTORC1 inhibition.
Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Cell Line, Tumor; Ceramides; Doxorubicin; Drug Resistance, Neoplasm; Humans; Mechanistic Target of Rapamycin Complex 1; Multiprotein Complexes; Neoplasms; Proteins; Reactive Oxygen Species; Ribonucleotides; TOR Serine-Threonine Kinases | 2010 |
Identification of aneuploidy-selective antiproliferation compounds.
Topics: Aminoimidazole Carboxamide; Aneuploidy; Animals; Antineoplastic Agents; Apoptosis; Benzoquinones; Cell Line; Cell Proliferation; Chloroquine; Chromosome Segregation; Drug Screening Assays, Antitumor; Embryo, Mammalian; Fibroblasts; Humans; Lactams, Macrocyclic; Mice; Neoplasms; Ribonucleotides; Trisomy | 2011 |
AICAR inhibits cancer cell growth and triggers cell-type distinct effects on OXPHOS biogenesis, oxidative stress and Akt activation.
Topics: Aminoimidazole Carboxamide; Cell Proliferation; Drug Evaluation, Preclinical; Enzyme Activation; HeLa Cells; Hep G2 Cells; Humans; Hypoglycemic Agents; Neoplasms; Oncogene Protein v-akt; Organ Specificity; Oxidative Phosphorylation; Oxidative Stress; Ribonucleotides; Time Factors; Tumor Cells, Cultured | 2011 |
Involvement of Akt2/protein kinase B β (PKBβ) in the 8-Cl-cAMP-induced cancer cell growth inhibition.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Antineoplastic Agents; Cell Death; Cell Line, Tumor; Cell Proliferation; HeLa Cells; Humans; MCF-7 Cells; Neoplasms; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Ribonucleotides | 2013 |
SAICAR stimulates pyruvate kinase isoform M2 and promotes cancer cell survival in glucose-limited conditions.
Topics: Allosteric Regulation; Aminoimidazole Carboxamide; Cell Survival; Fibroblasts; Glucose; HeLa Cells; Humans; Neoplasms; Pyruvate Kinase; Recombinant Proteins; Ribonucleosides; Tumor Microenvironment | 2012 |
In situ electrochemical evaluation of anticancer drug temozolomide and its metabolites-DNA interaction.
Topics: Aminoimidazole Carboxamide; Antineoplastic Agents, Alkylating; Biosensing Techniques; Dacarbazine; Diazonium Compounds; DNA; Electrochemical Techniques; Humans; Neoplasms; Oxidation-Reduction; Temozolomide | 2013 |
The incorporation of radiocarbon from 4-amino-5-imidazolecarboxamide into the purines of tumor-bearing mice.
Topics: Aminoimidazole Carboxamide; Animals; Imidazoles; Mice; Neoplasms; Purines | 1953 |
The effect of azaguanine on the incorporation of guanine and of 4-amino-5-imidazolecarboxamide into tumor-bearing mice.
Topics: Aminoimidazole Carboxamide; Animals; Azaguanine; Guanine; Imidazoles; Mice; Neoplasms | 1953 |
The effects of tumor growth and x-radiation on the incorporation of radiocarbon from 4-amino-5-imidazolecarboxamide-C14 into nucleic acids.
Topics: Aminoimidazole Carboxamide; Animals; Imidazoles; Neoplasms; Nucleic Acids; Sarcoma, Experimental; X-Rays | 1954 |
Small-molecule targeting of heat shock protein 90 chaperone function: rational identification of a new anticancer lead.
Topics: Aminoimidazole Carboxamide; Antineoplastic Agents; Apoptosis; Cell Proliferation; Combinatorial Chemistry Techniques; Computer Simulation; Drug Design; HSP90 Heat-Shock Proteins; Humans; Hypoglycemic Agents; Models, Molecular; Neoplasms; Peptide Fragments; Recombinant Proteins; Ribonucleotides; Tumor Cells, Cultured | 2006 |
A central role for neuronal adenosine 5'-monophosphate-activated protein kinase in cancer-induced anorexia.
Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Anorexia; Deoxyglucose; Drug Administration Routes; Hypothalamus; Male; Metformin; Multienzyme Complexes; Neoplasm Transplantation; Neoplasms; Neurons; Phosphorylation; Protein Serine-Threonine Kinases; Rats; Rats, Wistar; Ribonucleotides; Survival Analysis; Tumor Cells, Cultured | 2007 |
Live or let die: E2F1 and PI3K pathways intersect to make life or death decisions.
Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Cell Death; E2F1 Transcription Factor; Enzyme Activation; Gene Expression Regulation, Neoplastic; Humans; Multienzyme Complexes; Neoplasms; Phosphatidylinositol 3-Kinases; Protein Serine-Threonine Kinases; Rats; Ribonucleotides | 2008 |
An E2F1-dependent gene expression program that determines the balance between proliferation and cell death.
Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Cell Death; Cell Line, Tumor; Cell Proliferation; E2F1 Transcription Factor; Enzyme Activation; Gene Expression Regulation, Neoplastic; Genes, Neoplasm; Humans; Models, Biological; Multienzyme Complexes; Neoplasms; Phenotype; Phosphatidylinositol 3-Kinases; Protein Serine-Threonine Kinases; Rats; Repressor Proteins; Ribonucleotides; Serum; Signal Transduction | 2008 |