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aminoimidazole carboxamide and Injury, Myocardial Reperfusion

aminoimidazole carboxamide has been researched along with Injury, Myocardial Reperfusion in 30 studies

Research

Studies (30)

TimeframeStudies, this research(%)All Research%
pre-19901 (3.33)18.7374
1990's16 (53.33)18.2507
2000's7 (23.33)29.6817
2010's6 (20.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
An, R; Fan, R; Feng, N; Gu, X; Guo, H; Jia, M; Li, J; Pei, J; Tian, X; Yang, L; Zhang, S; Zhao, L; Zheng, G; Zhou, Y1
Liang, GY; Liu, DX; Wang, F; Yu, J; Zhang, DS1
Cieslik, KA; Crawford, JR; Entman, ML; Mejia Osuna, P; Taffet, GE; Trial, J1
Drew, BG; Kingwell, BA1
Bøtker, HE; Jessen, N; Kristiansen, SB; Lund, S; Løfgren, B; Nielsen, TT; Nielsen-Kudsk, JE; Schmitz, O; Solskov, L1
Hale, SL; Kloner, RA1
Davidson, SM; Gonçalves, LM; Mocanu, MM; Paiva, MA; Providência, LA; Yellon, DM1
Cao, Y; Gao, E; Lau, WB; Lian, K; Liu, S; Liu, Y; Lu, X; Ma, Y; Pei, H; Qu, Y; Sun, L; Tao, L; Wang, H; Wang, R; Xia, C; Yang, L; Yin, T1
Hardie, DG1
Dietzel, C; Mangano, DT; Miao, Y; Tudor, IC1
Kloner, RA1
Gaskin, FS; Kamada, K; Korthuis, RJ; Yusof, M1
Allen, DG; Chen, ZP; Jiang, L; Kemp, BE; Moopanar, TR; Xiao, XH1
Bullough, D; Galiñanes, M; Hearse, DJ; Mullane, KM; Zhai, X1
Alkhulaifi, AM; Pugsley, WB1
Gruver, EJ; Marsh, JD; Smith, TW; Toupin, D1
Kingma, JG; Rouleau, JR; Simard, D1
Dai, HB; Friedman, M; Johnson, RG; Piana, RN; Sellke, FW; Wang, SY1
Engler, RL1
McGee, DS; Nakanishi, K; Tan, P; Vinten-Johansen, J; Zhao, ZQ1
Bullough, DA; Fox, MH; Metzner, EK; Mullane, KM; Potter, S; Zhang, C1
Barner, HB; Gatell, JA; Shevde, K1
Mullane, K1
Hoshi, K; Ichihara, K; Kano, S; Nakai, T; Satoh, K1
Buggé, CJ; Bullough, DA; Kurz, MA; Mullane, KM; Young, MA1
Cheng, TO1
Hill, GE1
Bullough, D; Galiñanes, M; Hearse, DJ; Mullane, KM2
Engler, RL; Gruber, HE; Hoffer, ME; Laikind, PK; Lane, TA; McAllister, DR; Schmid-Schoenbein, GW1

Reviews

6 review(s) available for aminoimidazole carboxamide and Injury, Myocardial Reperfusion

ArticleYear
Acadesine, an adenosine-regulating agent with the potential for widespread indications.
    Expert opinion on pharmacotherapy, 2008, Volume: 9, Issue:12

    Topics: Adenosine; Aminoimidazole Carboxamide; Coronary Artery Bypass; Diabetes Mellitus; Humans; Infusions, Intravenous; Leukemia, Lymphocytic, Chronic, B-Cell; Myocardial Reperfusion Injury; Ribonucleosides

2008
AMP-activated protein kinase: the guardian of cardiac energy status.
    The Journal of clinical investigation, 2004, Volume: 114, Issue:4

    Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Apoptosis; Energy Metabolism; Enzyme Activation; Humans; Models, Biological; Multienzyme Complexes; Myocardial Ischemia; Myocardial Reperfusion Injury; Myocardium; Necrosis; Protein Serine-Threonine Kinases; Ribonucleosides; Trans-Activators

2004
Harnessing nature's own cardiac defense mechanism with acadesine, an adenosine regulating agent: importance of the endothelium.
    Journal of cardiac surgery, 1994, Volume: 9, Issue:3 Suppl

    Topics: Adenosine; Aminoimidazole Carboxamide; Animals; Endothelium, Vascular; Heart; Humans; Myocardial Reperfusion Injury; Myocardial Stunning; Ribonucleosides

1994
Adenosine and myocardial protection.
    Journal of cardiothoracic and vascular anesthesia, 1993, Volume: 7, Issue:4

    Topics: Adenosine; Aminoimidazole Carboxamide; Coronary Artery Bypass; Humans; Myocardial Reperfusion Injury; Ribonucleotides

1993
Acadesine: the prototype adenosine regulating agent for reducing myocardial ischaemic injury.
    Cardiovascular research, 1993, Volume: 27, Issue:1

    Topics: Adenosine; Adenosine Triphosphate; Aminoimidazole Carboxamide; Animals; Dogs; Guinea Pigs; Humans; Myocardial Reperfusion Injury; Myocardium; Rats; Ribonucleosides

1993
Cardiopulmonary bypass-induced inflammation: is it important?
    Journal of cardiothoracic and vascular anesthesia, 1998, Volume: 12, Issue:2 Suppl 1

    Topics: Aminoimidazole Carboxamide; Anti-Inflammatory Agents; Cardiopulmonary Bypass; Cell Adhesion; Child; Cytokines; Down-Regulation; Endothelium, Vascular; Endotoxins; Hemofiltration; Humans; Inflammation Mediators; Intercellular Adhesion Molecule-1; Interleukin-1; Interleukin-6; Macrophage-1 Antigen; Myocardial Ischemia; Myocardial Reperfusion Injury; Neutrophils; Nitric Oxide; Nitric Oxide Synthase; Platelet Activation; Ribonucleosides; Serine Proteinase Inhibitors; Systemic Inflammatory Response Syndrome; Tumor Necrosis Factor-alpha; Up-Regulation; Ventricular Dysfunction, Left

1998

Trials

1 trial(s) available for aminoimidazole carboxamide and Injury, Myocardial Reperfusion

ArticleYear
Post-reperfusion myocardial infarction: long-term survival improvement using adenosine regulation with acadesine.
    Journal of the American College of Cardiology, 2006, Jul-04, Volume: 48, Issue:1

    Topics: Adenosine; Aged; Aminoimidazole Carboxamide; Coronary Artery Bypass; Double-Blind Method; Female; Humans; Male; Middle Aged; Myocardial Infarction; Myocardial Reperfusion Injury; Preoperative Care; Ribonucleosides; Risk Factors; Survival Rate

2006

Other Studies

23 other study(ies) available for aminoimidazole carboxamide and Injury, Myocardial Reperfusion

ArticleYear
κ-opioid receptor activation protects against myocardial ischemia-reperfusion injury via AMPK/Akt/eNOS signaling activation.
    European journal of pharmacology, 2018, Aug-15, Volume: 833

    Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Cell Line; Cell Survival; Male; Myocardial Reperfusion Injury; Myocytes, Cardiac; Naltrexone; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase Type III; Proto-Oncogene Proteins c-akt; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Ribonucleotides; Signal Transduction; Troponin T

2018
Role of Phosphorylated AMP-Activated Protein Kinase (AMPK) in Myocardial Insulin Resistance After Myocardial Ischemia-Reperfusion During Cardiopulmonary Bypass Surgery in Dogs.
    Medical science monitor : international medical journal of experimental and clinical research, 2019, Jun-04, Volume: 25

    Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Cardioplegic Solutions; Cardiopulmonary Bypass; China; Coronary Artery Disease; Dogs; Female; Glucose; Glucose Transporter Type 4; Heart Ventricles; Insulin Resistance; Ischemia; Male; Myocardial Ischemia; Myocardial Reperfusion; Myocardial Reperfusion Injury; Myocardium; Phosphorylation; Pyrazoles; Pyrimidines; Ribonucleotides

2019
AICAR-dependent AMPK activation improves scar formation in the aged heart in a murine model of reperfused myocardial infarction.
    Journal of molecular and cellular cardiology, 2013, Volume: 63

    Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Cicatrix; Disease Models, Animal; Enzyme Activation; Fibroblasts; Male; Mice; Myocardial Infarction; Myocardial Reperfusion Injury; Myofibroblasts; Phosphorylation; Ribonucleotides; Ventricular Remodeling; Wound Healing

2013
5-Aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside increases myocardial glucose uptake during reperfusion and induces late pre-conditioning: potential role of AMP-activated protein kinase.
    Basic & clinical pharmacology & toxicology, 2009, Volume: 105, Issue:1

    Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Blood Glucose; Glucose; Glucose Transporter Type 4; Glycogen; Heart; Ischemic Preconditioning, Myocardial; Male; Myocardial Infarction; Myocardial Reperfusion Injury; Myocardium; Physical Exertion; Protective Agents; Random Allocation; Rats; Rats, Wistar; Ribonucleotides; Ventricular Pressure

2009
Cardioprotection with adenosine-regulating agent, GP531: effects on no-reflow, infarct size, and blood flow following ischemia/ reperfusion in the rabbit.
    Journal of cardiovascular pharmacology and therapeutics, 2010, Volume: 15, Issue:1

    Topics: Adenosine; Aminoimidazole Carboxamide; Analysis of Variance; Animals; Deoxyribonucleosides; Disease Models, Animal; Hemodynamics; Male; Myocardial Infarction; Myocardial Ischemia; Myocardial Reperfusion Injury; Rabbits; Random Allocation

2010
Transitory activation of AMPK at reperfusion protects the ischaemic-reperfused rat myocardium against infarction.
    Cardiovascular drugs and therapy, 2010, Volume: 24, Issue:1

    Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Enzyme Activation; Heart; Hemodynamics; Hypoglycemic Agents; Infarction; Male; Metformin; Myocardial Reperfusion Injury; Myocardium; Phosphorylation; Protein Kinase Inhibitors; Pyrazoles; Pyrimidines; Rats; Rats, Wistar; Ribonucleotides

2010
Dynamic alteration of adiponectin/adiponectin receptor expression and its impact on myocardial ischemia/reperfusion in type 1 diabetic mice.
    American journal of physiology. Endocrinology and metabolism, 2011, Volume: 301, Issue:3

    Topics: Adenylate Kinase; Adiponectin; Aminoimidazole Carboxamide; Animals; Apoptosis; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Mice; Myocardial Ischemia; Myocardial Reperfusion; Myocardial Reperfusion Injury; Myocardium; Myocytes, Cardiac; Receptors, Adiponectin; Ribonucleotides

2011
Moving preconditioning from bench to bedside.
    Journal of the American College of Cardiology, 2006, Jul-04, Volume: 48, Issue:1

    Topics: Adenosine; Aminoimidazole Carboxamide; Animals; Coronary Artery Bypass; Humans; Ischemic Preconditioning, Myocardial; Myocardial Infarction; Myocardial Reperfusion Injury; Ribonucleosides; Survival Rate

2006
5'-AMP-activated protein kinase activation prevents postischemic leukocyte-endothelial cell adhesive interactions.
    American journal of physiology. Heart and circulatory physiology, 2007, Volume: 292, Issue:1

    Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Cell Adhesion; Endothelial Cells; Enzyme Activation; Ischemic Preconditioning, Myocardial; Leukocytes; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Multienzyme Complexes; Myocardial Reperfusion Injury; Protein Serine-Threonine Kinases; Ribonucleotides; Treatment Outcome

2007
AICAR inhibits the Na+/H+ exchanger in rat hearts--possible contribution to cardioprotection.
    Pflugers Archiv : European journal of physiology, 2006, Volume: 453, Issue:2

    Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Cardiotonic Agents; Female; Heart; Heart Ventricles; Hypoglycemic Agents; In Vitro Techniques; Multienzyme Complexes; Myocardial Reperfusion Injury; Myocytes, Cardiac; Protein Serine-Threonine Kinases; Rats; Rats, Sprague-Dawley; Ribonucleotides; Sodium-Hydrogen Exchangers

2006
Protection against injury during ischemia and reperfusion by acadesine derivatives GP-1-468 and GP-1-668. Studies in the transplanted rat heart.
    The Journal of thoracic and cardiovascular surgery, 1995, Volume: 110, Issue:3

    Topics: Adenosine; Adenosine Diphosphate; Adenosine Monophosphate; Adenosine Triphosphate; Aminoimidazole Carboxamide; Animals; Coronary Circulation; Heart Transplantation; Male; Myocardial Contraction; Myocardial Ischemia; Myocardial Reperfusion Injury; Myocardium; Rats; Rats, Inbred Lew; Ribonucleosides; Ribonucleotides; Ventricular Pressure

1995
Role of acadesine in clinical myocardial protection.
    British heart journal, 1995, Volume: 73, Issue:4

    Topics: Aminoimidazole Carboxamide; Clinical Trials as Topic; Humans; Myocardial Infarction; Myocardial Ischemia; Myocardial Reperfusion Injury; Ribonucleosides

1995
Acadesine improves tolerance to ischemic injury in rat cardiac myocytes.
    Journal of molecular and cellular cardiology, 1994, Volume: 26, Issue:9

    Topics: Aminoimidazole Carboxamide; Animals; Disease Models, Animal; Female; Heart; In Vitro Techniques; Myocardial Contraction; Myocardial Reperfusion Injury; Purinergic P1 Receptor Antagonists; Rats; Rats, Sprague-Dawley; Ribonucleosides; Theophylline

1994
Timely administration of AICA riboside reduces reperfusion injury in rabbits.
    Cardiovascular research, 1994, Volume: 28, Issue:7

    Topics: Aminoimidazole Carboxamide; Animals; Autoradiography; Disease Models, Animal; Male; Myocardial Infarction; Myocardial Reperfusion Injury; Myocardium; Rabbits; Ribonucleosides; Tetrazolium Salts

1994
Adenosine and AICA-riboside fail to enhance microvascular endothelial preservation.
    The Annals of thoracic surgery, 1994, Volume: 58, Issue:1

    Topics: Adenosine; Aminoimidazole Carboxamide; Animals; Blood; Bradykinin; Calcimycin; Cardioplegic Solutions; Cardiopulmonary Bypass; Coronary Vessels; Endothelium, Vascular; Female; Heart Arrest, Induced; Male; Muscle, Smooth, Vascular; Myocardial Reperfusion Injury; Nitroprusside; Ribonucleosides; Swine

1994
Acadesine improves surgical myocardial protection with blood cardioplegia in ischemically injured canine hearts.
    Circulation, 1993, Volume: 88, Issue:5 Pt 2

    Topics: Aminoimidazole Carboxamide; Animals; Blood; Dogs; Dose-Response Relationship, Drug; Heart Arrest, Induced; Myocardial Contraction; Myocardial Reperfusion Injury; Premedication; Ribonucleosides; Time Factors; Ventricular Function, Left

1993
Acadesine prevents oxidant-induced damage in the isolated guinea pig heart.
    The Journal of pharmacology and experimental therapeutics, 1993, Volume: 266, Issue:2

    Topics: Aminoimidazole Carboxamide; Animals; Antioxidants; Guinea Pigs; Heart; Hypochlorous Acid; Imidazoles; In Vitro Techniques; Male; Myocardial Reperfusion Injury; Reactive Oxygen Species; Ribonucleosides

1993
Effects of adenine nucleotide analogues on myocardial dysfunction during reperfusion after ischemia in dogs.
    Journal of cardiovascular pharmacology, 1996, Volume: 28, Issue:2

    Topics: 8-Bromo Cyclic Adenosine Monophosphate; Adenine Nucleotides; Adenosine Monophosphate; Aminoimidazole Carboxamide; Animals; Carbohydrate Metabolism; Cardiomyopathies; Coronary Circulation; Dogs; Female; Hemodynamics; Male; Myocardial Contraction; Myocardial Ischemia; Myocardial Reperfusion Injury; Myocardium; Ribonucleotides

1996
Cardioprotection with a novel adenosine regulating agent mediated by intravascular adenosine.
    European journal of pharmacology, 1997, Mar-19, Volume: 322, Issue:2-3

    Topics: Adenosine; Aminoimidazole Carboxamide; Animals; Cardiotonic Agents; Deoxyribonucleosides; Female; Hemodynamics; Male; Myocardial Ischemia; Myocardial Reperfusion Injury; Swine; Swine, Miniature

1997
Adenosine and K(+)-induced Ca2+ loading.
    The Annals of thoracic surgery, 1997, Volume: 64, Issue:2

    Topics: Adenosine; Aminoimidazole Carboxamide; Animals; Calcium; Cardioplegic Solutions; Humans; Myocardial Reperfusion Injury; Myocardium; Potassium; Ribonucleosides

1997
Sustained protection by acadesine against ischemia- and reperfusion-induced injury. Studies in the transplanted rat heart.
    Circulation, 1992, Volume: 86, Issue:2

    Topics: Abdomen; Adenine Nucleotides; Adenosine; Aminoimidazole Carboxamide; Animals; Bicarbonates; Calcium Chloride; Cardioplegic Solutions; Heart Transplantation; Magnesium; Male; Myocardial Contraction; Myocardial Reperfusion; Myocardial Reperfusion Injury; Myocardium; Potassium Chloride; Rats; Rats, Inbred Lew; Ribonucleosides; Sodium Chloride; Time Factors; Transplantation, Heterotopic

1992
Acadesine and myocardial protection. Studies of time of administration and dose-response relations in the rat.
    Circulation, 1992, Volume: 86, Issue:2

    Topics: Adenine Nucleotides; Aminoimidazole Carboxamide; Animals; Bicarbonates; Calcium Chloride; Cardioplegic Solutions; Dose-Response Relationship, Drug; Magnesium; Male; Myocardial Contraction; Myocardial Reperfusion Injury; Myocardium; Potassium Chloride; Rats; Rats, Inbred Strains; Ribonucleosides; Sodium Chloride; Time Factors

1992
Increased adenosine concentration in blood from ischemic myocardium by AICA riboside. Effects on flow, granulocytes, and injury.
    Circulation, 1989, Volume: 80, Issue:5

    Topics: Adenosine; Adenosine Triphosphate; Aminoimidazole Carboxamide; Animals; Cells, Cultured; Collateral Circulation; Coronary Circulation; Dogs; Granulocytes; Imidazoles; In Vitro Techniques; Myocardial Reperfusion Injury; Myocardium; Ribonucleosides; Superoxides

1989