Compounds > aminoimidazole carboxamide
Page last updated: 2024-08-21

aminoimidazole carboxamide and Disease Models, Animal

aminoimidazole carboxamide has been researched along with Disease Models, Animal in 82 studies

Research

Studies (82)

TimeframeStudies, this research(%)All Research%
pre-19901 (1.22)18.7374
1990's7 (8.54)18.2507
2000's13 (15.85)29.6817
2010's55 (67.07)24.3611
2020's6 (7.32)2.80

Authors

AuthorsStudies
Dang, TN; Floyd, ZE; Kuhn, P; Pauli, GF; Poulev, A; Ribnicky, DM; Simmler, C; Vandanmagsar, B; Yu, Y1
Iso, T; Kawakami, R; Koitabashi, N; Kurabayashi, M; Matsui, H; Murakami, M; Obokata, M; Sunaga, H; Yokoyama, T1
Abdullahi, A; Auger, C; Jeschke, MG; Knuth, CM; Parousis, A; Samadi, O1
Athineos, D; Blanco, GR; Blyth, K; Brunton, H; Dhayade, S; Fernandez-de-Cossio-Diaz, J; Lilla, S; Mackay, GM; Meiser, J; Oizel, K; Pietzke, M; Sumpton, D; Tait-Mulder, J; Vazquez, A; Zanivan, SR1
Kim, SW; Nuwormegbe, SA1
Albuquerque, B; Andersen, NR; Birk, JB; Carling, D; Jørgensen, NO; Kjøbsted, R; Larsen, MR; Miller, R; Pehmøller, CK; Schjerling, P; Wojtaszewski, JFP1
Fu, CN; Gao, WS; Qu, YJ; Song, SS; Wei, H; Yue, SW1
Cao, L; Ji, L; Li, H; Mao, K; Sha, L; Tang, X; Wei, J; Wei, N; Wu, J; Xie, W; Yang, S; Yang, Z; Zhu, L1
Choi, S; Samuvel, DJ; Saxena, N; Singh, AK; Singh, I; Won, J1
Al-Rewashdy, A; Bélanger, G; Jasmin, BJ; Ravel-Chapuis, A1
Hasko, G; Pacher, P; Ungvari, Z; Yabluchanskiy, A1
Calo, N; Clavien, PA; Dufour, JF; Foti, M; Frick, L; Graf, R; Humar, B; Kachaylo, E; Kambakamba, P; Kron, P; Langiewicz, M; Limani, P; Linecker, M; Schneider, MA; Tian, Y; Tschuor, C; Ungethüm, U1
Hughey, CC; Hunter, RW; Jessen, N; Lantier, L; Peggie, M; Sakamoto, K; Sicheri, F; Sundelin, EI; Wasserman, DH; Zeqiraj, E1
Gao, J; Jiang, G; Xiong, D; Xiong, R; Yin, T; Yin, Z; Zhang, S; Zhang, X; Zhao, W1
Cao, Y; Gu, C; Han, Y; Sun, G; Wang, Y; Wang, Z; Xu, M; Yin, Q; Zhu, H1
Chai, Y; Dong, D; Hu, L; Liu, W; Lv, Y; Ma, T; Wu, R; Zhang, N; Zhu, H1
Dong, Z; George, J; Hu, L; Lv, Y; Su, L; Wang, J; Wu, Y1
Hu, L; Hu, XF; Li, HP; Li, M; Lin, LX; Liu, WT; Pan, HL; Shu, Y; Xiang, HC; Zhang, RY; Zhao, YL; Zhu, H1
Lin, JR; Nakagawasai, O; Nemoto, W; Odaira, T; Sakuma, W; Takahashi, K; Tan-No, K1
Banek, CT; Bauer, AJ; Dreyer, HC; Gilbert, JS; Needham, KM1
Awazu, Y; Hirayama, T; Hori, A; Imamura, S; Iwata, H; Miki, H; Miwa, K; Miyamoto, N; Oguro, Y; Okada, K; Oki, H; Sakai, N; Takagi, T; Takeuchi, T; Yamasaki, S1
Cieslik, KA; Crawford, JR; Entman, ML; Mejia Osuna, P; Taffet, GE; Trial, J1
Chang, KH; Kim, YG; Lee, MY; Liu, Y; Oh, SJ1
Komen, JC; Thorburn, DR1
Ji, L; Li, H; Liu, W; Zhai, X1
Beà, S; Campàs, C; Colomer, D; de Frias, M; Kalko, SG; López-Guerra, M; Montraveta, A; Pérez-Galán, P; Rosich, L; Roué, G; Salaverria, I; Xargay-Torrent, S1
Horne, MK; Kemp, BE; Perera, ND; Scott, JW; Sheean, RK; Turner, BJ1
Altman, MD; Bachman, E; Bouthillette, M; Chan, G; Childers, KK; Haidle, AM; Marshall, CG; Mathur, A; Mo, JR; Rosenstein, C; Rush, T; Tempest, P; Xu, L; Young, JR; Zabierek, AA1
Amrutkar, M; Cansby, E; Durán, EN; Mahlapuu, M; Nerstedt, A; Smith, U1
Chai, DM; Du, LL; Li, XH; Liu, LB; Liu, R; Wang, JZ; Wu, K; Zhang, FC; Zhang, HB; Zhao, LN; Zhou, XW1
Al-Rewashdy, H; Jasmin, BJ; Lin, W; Ljubicic, V; Renaud, JM1
Miyamoto, S; Sharma, K; You, YH; Zhao, J1
Hu, XG; Liu, B; Ma, LJ; Qi, Y; Shang, JY; Sun, BB; Zhang, GJ1
Ai, Q; Che, Q; Ge, P; Gong, X; Lin, L; Wan, J; Wen, A; Zhang, L; Zhou, D1
Choi, JS; Choi, W; Cui, L; Li, Z; Park, MJ; Park, SH; Sung, MS; Yoon, KC1
Chen, B; Li, J; Zhu, H1
Ji, L; Li, H; Liu, W; Wang, Y1
Calderó, J; Cerveró, C; Esquerda, JE; Montull, N; Piedrafita, L; Tarabal, O1
Cambon, K; Déglon, N; Dolores Sequedo, M; Farina, F; Millán, JM; Neri, C; Parker, AJ; Vázquez-Manrique, RP; Weiss, A1
Dong, M; Ren, J; Ren, SY; Wang, Q; Xu, X; Zhang, Y1
Kim, DM; Leem, YH1
Giri, S; Kumar, A1
Fujinami, K; Kamoshita, M; Ozawa, Y; Toda, E; Tsubota, K1
Arguello, T; Diaz, F; Garcia, S; Moraes, CT; Peralta, S; Yin, HY1
Angelini, C; Brockhoff, M; Castets, P; Chojnowska, K; Eickhorst, C; Erne, B; Frank, S; Furling, D; Rion, N; Rüegg, MA; Sinnreich, M; Wiktorowicz, T1
Hake, PW; Kim, P; Klingbeil, LR; O'Connor, M; Piraino, G; Wolfe, V; Zingarelli, B1
Ma, A; Wang, J; Zhao, M; Zhu, H1
Chakour, KS; Freund, GG; Guest, CB1
Choi, A; Javadov, S; Karmazyn, M; Kilić, A; Rajapurohitam, V; Zeidan, A1
Brown, S; Cheng, H; Ding, Y; Fan, X; McCrimmon, RJ; McNay, EC; Shaw, M; Sherwin, RS; Vella, MC; Zhou, L1
Choi, JH; Lee, HK; Lee, W; Pak, YK; Park, KS; Park, SY; Ryu, HS1
Hale, SL; Kloner, RA1
Belcher, JD; Geng, JG; Huo, Y; Slungaard, A; Tang, R; Viollet, B; Wang, H; Wang, J; Wu, C; Zhang, C; Zhang, W; Zhu, C1
Borst, AJ; Kruse, CG; Lange, JH; van der Neut, MA; van Stuivenberg, HH; van Vliet, BJ; Yildirim, M1
Li, D; Ling, W; Ma, J; Xia, M; Zhang, Y1
Matsumoto, Y; Sekimizu, K; Sugita, T; Sumiya, E1
Cai, X; Chen, B; Dong, Y; Liu, G; Mai, W; Meng, R; Pei, Z; Wei, J; Zhang, A; Zhou, Y1
Bottani, E; Cerutti, R; Civiletto, G; Fagiolari, G; Lamperti, C; Moggio, M; Schon, EA; Viscomi, C; Zeviani, M1
Kayama, M; Manola, A; Miller, JW; Morizane, Y; Murakami, Y; Sobrin, L; Suzuki, J; Takeuchi, K; Vavvas, DG1
Jasmin, BJ; Khogali, S; Ljubicic, V; Renaud, JM1
Loeken, MR; Thirumangalathu, S; Viana, M; Wu, Y1
Acevedo-Duncan, M; Braun, U; Farese, RV; Fields, AP; Kahn, CR; Leitges, M; Mastorides, S; Nimal, S; Sajan, MP1
Miller, JW; Morizane, Y; Murakami, Y; Simeonova, M; Sobrin, L; Suzuki, J; Takeuchi, K; Vavvas, DG; Yoshimura, T1
Chae, HJ; Jeon, MS; Kim, DI; Kim, SR; Lee, KS; Lee, YC; Park, SJ; Yoo, WH1
Liang, B; Viollet, B; Wang, Q; Wang, S; Zhang, W; Zhu, Y; Zou, MH1
Chavin, K; Lin, A; Orak, J; Sekhon, B; Sekhon, C; Singh, A; Singh, I; Smith, A1
Landree, LE; Li, H; McCullough, LD; McFadden, J; Ronnett, GV; Zeng, Z1
Bartrons, R; Carrasco-Chaumel, E; Casillas, A; Franco-Gou, R; Gelpí, E; Peralta, C; Rodés, J; Roselló-Catafau, J; Xaus, C1
Giri, S; Nath, N; Prasad, R; Singh, AK; Singh, I1
Chen, D; Dong, YG; Li, HL; Liu, D; Wang, D; Yang, Q; Yin, R1
Burckhartt, B; Cohen, MV; Downey, JM; Mullane, KM; Tsuchida, A; Yang, XM1
Fabian, TC; Kudsk, KA; Proctor, KG; Spiers, JP1
Gruver, EJ; Marsh, JD; Smith, TW; Toupin, D1
Bullough, DA; Montag, A; Mullane, KM; Young, MA; Zhang, C1
Kingma, JG; Rouleau, JR; Simard, D1
Cronstein, BN; Naime, D; Ostad, E1
Buckley, MT; Carlin, G; Cronstein, BN; Gadangi, P; Levin, RI; Longaker, M; Montesinos, MC; Naime, D; Recht, PA1
Davis, KA; Fabian, TC; Proctor, KG; Ragsdale, DN; Trenthem, LL1
Proctor, KG; Ragsdale, DN1
Croce, MA; Davis, KA; Fabian, TC; Proctor, KG; Ragsdale, DN; Trenthem, LL1
Fiedler, M; Liang, Y; Sakariassen, KS; Selén, G; Wallberg-Henriksson, H; Zierath, JR1
Jeney, A; Kovalszky, I; Lapis, K; Schawartz, J; Szende, B; Szepesházi, K; Takács, J; Tompa, A; Ujhelyi, E1

Reviews

1 review(s) available for aminoimidazole carboxamide and Disease Models, Animal

ArticleYear
Turn up the power - pharmacological activation of mitochondrial biogenesis in mouse models.
    British journal of pharmacology, 2014, Volume: 171, Issue:8

    Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Bezafibrate; Disease Models, Animal; Energy Metabolism; Mitochondria; Mitochondrial Diseases; Mitochondrial Turnover; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; Resveratrol; Ribonucleotides; Sirtuin 1; Stilbenes; Transcription Factors; Up-Regulation

2014

Other Studies

81 other study(ies) available for aminoimidazole carboxamide and Disease Models, Animal

ArticleYear
Bioactive compounds from Artemisia dracunculus L. activate AMPK signaling in skeletal muscle.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2021, Volume: 143

    Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Artemisia; Cell Line; Diet, High-Fat; Disease Models, Animal; Enzyme Activation; Enzyme Activators; Hypoglycemic Agents; Insulin Resistance; Male; Metformin; Mice, Inbred C57BL; Muscle, Skeletal; Myoblasts, Skeletal; Phosphorylation; Phytochemicals; Plant Extracts; Ribonucleotides; Signal Transduction

2021
Activation of cardiac AMPK-FGF21 feed-forward loop in acute myocardial infarction: Role of adrenergic overdrive and lipolysis byproducts.
    Scientific reports, 2019, 08-14, Volume: 9, Issue:1

    Topics: Adrenergic Agents; Aged; Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Angina Pectoris; Animals; Catecholamines; Disease Models, Animal; Fatty Acid-Binding Proteins; Fatty Acids; Female; Fibroblast Growth Factors; Humans; Lipolysis; Male; Multivariate Analysis; Myocardial Infarction; Myocardium; Myocytes, Cardiac; Recombinant Proteins; Ribonucleotides; Time Factors; Troponin T

2019
Metformin prevents the pathological browning of subcutaneous white adipose tissue.
    Molecular metabolism, 2019, Volume: 29

    Topics: Acetyl-CoA Carboxylase; Adipocytes, Beige; Adipose Tissue, White; Adult; Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Burns; Disease Models, Animal; Humans; Lipolysis; Metformin; Mice; Mice, Inbred C57BL; Mitochondria; Okadaic Acid; Oxidative Phosphorylation; Protein Phosphatase 2; Ribonucleosides; Sterol Esterase; Subcutaneous Fat

2019
Formate induces a metabolic switch in nucleotide and energy metabolism.
    Cell death & disease, 2020, 05-04, Volume: 11, Issue:5

    Topics: Adenosine Triphosphate; Adenylate Kinase; Aminoimidazole Carboxamide; Animals; Cell Line, Tumor; Colorectal Neoplasms; Disease Models, Animal; Energy Metabolism; Female; Formates; Humans; Mice, Inbred C57BL; Models, Biological; Models, Genetic; Nucleotides; Orotic Acid; Pyrimidines; Ribonucleotides

2020
AMPK Activation by 5-Amino-4-Imidazole Carboxamide Riboside-1-β-D-Ribofuranoside Attenuates Alkali Injury-Induced Corneal Fibrosis.
    Investigative ophthalmology & visual science, 2020, 06-03, Volume: 61, Issue:6

    Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Cells, Cultured; Cornea; Disease Models, Animal; Eye Burns; Fibroblasts; Fibrosis; Humans; Immunohistochemistry; Male; Mice; Mice, Inbred BALB C

2020
Direct small molecule ADaM-site AMPK activators reveal an AMPKγ3-independent mechanism for blood glucose lowering.
    Molecular metabolism, 2021, Volume: 51

    Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Blood Glucose; Diet, High-Fat; Disease Models, Animal; Female; Humans; Mice; Mice, Knockout; Muscle, Skeletal; Obesity; Phosphorylation; Ribonucleotides; Signal Transduction

2021
Obesity increases neuropathic pain via the AMPK-ERK-NOX4 pathway in rats.
    Aging, 2021, 07-29, Volume: 13, Issue:14

    Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Apoptosis; Butadienes; Diet, High-Fat; Disease Models, Animal; Enzyme Inhibitors; Ganglia, Spinal; Hypoglycemic Agents; Inflammation; Male; MAP Kinase Signaling System; Metformin; NADPH Oxidase 4; Neuralgia; Nitriles; Obesity; Oxidative Stress; Pain Threshold; Phosphorylation; Rats, Wistar; Ribonucleotides; Spinal Cord

2021
Insulin degrading enzyme contributes to the pathology in a mixed model of Type 2 diabetes and Alzheimer's disease: possible mechanisms of IDE in T2D and AD.
    Bioscience reports, 2018, 02-28, Volume: 38, Issue:1

    Topics: Alzheimer Disease; Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Amyloid beta-Peptides; Animals; Blood Glucose; Diabetes Mellitus, Type 2; Disease Models, Animal; Fasting; Gene Expression Regulation; Glucose Tolerance Test; Humans; Insulin; Insulysin; Learning; Mice; Mice, Transgenic; PPAR gamma; Ribonucleotides; Rosiglitazone; Streptozocin; Thiazolidinediones

2018
Combination therapy of lovastatin and AMP-activated protein kinase activator improves mitochondrial and peroxisomal functions and clinical disease in experimental autoimmune encephalomyelitis model.
    Immunology, 2018, Volume: 154, Issue:3

    Topics: Adenosine Triphosphate; Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Biomarkers; Cell Line; Cytokines; Disease Models, Animal; Encephalomyelitis, Autoimmune, Experimental; Female; Gene Expression; Humans; Lovastatin; Mice; Mitochondria; Peroxisomes; rho-Associated Kinases; rhoA GTP-Binding Protein; Ribonucleotides; Spinal Cord

2018
Pharmacological and physiological activation of AMPK improves the spliceopathy in DM1 mouse muscles.
    Human molecular genetics, 2018, 10-01, Volume: 27, Issue:19

    Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinase Kinases; Animals; Disease Models, Animal; Humans; Mice; Motor Activity; Muscle, Skeletal; Myoblasts; Myotonic Dystrophy; Protein Kinases; Resveratrol; Ribonucleotides; RNA-Binding Proteins; RNA, Messenger; Trinucleotide Repeat Expansion

2018
Age-dependent cardiovascular effects of sepsis in a murine model of cecal ligation and puncture: implications for the design of interventional studies.
    American journal of physiology. Heart and circulatory physiology, 2018, Nov-01, Volume: 315, Issue:5

    Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Cecum; Disease Models, Animal; Ligation; Mice; Punctures; Ribonucleotides; Sepsis

2018
Exercise Improves Outcomes of Surgery on Fatty Liver in Mice: A Novel Effect Mediated by the AMPK Pathway.
    Annals of surgery, 2020, Volume: 271, Issue:2

    Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Disease Models, Animal; Fatty Liver; Glucose Tolerance Test; Hepatectomy; Insulin; Liver Regeneration; Male; Mice; Mice, Inbred C57BL; Physical Conditioning, Animal; Reperfusion Injury; Ribonucleotides

2020
Metformin reduces liver glucose production by inhibition of fructose-1-6-bisphosphatase.
    Nature medicine, 2018, Volume: 24, Issue:9

    Topics: Adenosine Monophosphate; Aminoimidazole Carboxamide; Animals; Base Sequence; Chickens; Disease Models, Animal; Fructose-Bisphosphatase; Glucose; Glucose Intolerance; Homeostasis; Humans; Hypoglycemia; Liver; Metformin; Mice, Inbred C57BL; Mutation; Obesity; Prodrugs; Ribonucleotides

2018
The Adenosine Monophosphate (AMP) Analog, 5-Aminoimidazole-4-Carboxamide Ribonucleotide (AICAR) Inhibits Hepatosteatosis and Liver Tumorigenesis in a High-Fat Diet Murine Model Treated with Diethylnitrosamine (DEN).
    Medical science monitor : international medical journal of experimental and clinical research, 2018, Nov-26, Volume: 24

    Topics: Adenosine Monophosphate; Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Carcinogenesis; Carcinoma, Hepatocellular; Diet, High-Fat; Diethylnitrosamine; Disease Models, Animal; Fatty Liver; Interleukin-6; Lipid Metabolism; Liver Neoplasms; Male; Mice; Mice, Inbred C57BL; Ribonucleotides; STAT3 Transcription Factor; Triglycerides

2018
Activation of AMPK alleviates cardiopulmonary bypass-induced cardiac injury via ameliorating acute cardiac glucose metabolic disorder.
    Cardiovascular therapeutics, 2018, Volume: 36, Issue:6

    Topics: Adenosine Triphosphate; Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Blood Glucose; Cardiopulmonary Bypass; Creatine Kinase, MB Form; Disease Models, Animal; Enzyme Activation; Enzyme Activators; Glucose Metabolism Disorders; Glucose Transporter Type 4; GTPase-Activating Proteins; Heart Diseases; Male; Myocardium; Phosphorylation; Rats, Sprague-Dawley; Ribonucleotides; Signal Transduction; Troponin I

2018
AICAR-Induced AMPK Activation Inhibits the Noncanonical NF-κB Pathway to Attenuate Liver Injury and Fibrosis in BDL Rats.
    Canadian journal of gastroenterology & hepatology, 2018, Volume: 2018

    Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Bile Ducts; Cholestasis; Chronic Disease; Disease Models, Animal; Kupffer Cells; Ligation; Liver; Liver Cirrhosis; NF-kappa B; Protective Agents; Rats; Ribonucleotides; Signal Transduction

2018
AMPK agonist AICAR ameliorates portal hypertension and liver cirrhosis via NO pathway in the BDL rat model.
    Journal of molecular medicine (Berlin, Germany), 2019, Volume: 97, Issue:3

    Topics: Actins; Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Bile Ducts; Disease Models, Animal; Endothelial Cells; Hepatic Stellate Cells; Hypertension, Portal; Ligation; Liver Cirrhosis; Male; Nitric Oxide; Nitric Oxide Synthase Type III; Rats, Sprague-Dawley; Ribonucleotides; Signal Transduction; Transforming Growth Factor beta

2019
AMPK activation attenuates inflammatory pain through inhibiting NF-κB activation and IL-1β expression.
    Journal of neuroinflammation, 2019, Feb-12, Volume: 16, Issue:1

    Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Anti-Inflammatory Agents; Antigens, CD; Antigens, Differentiation, Myelomonocytic; CX3C Chemokine Receptor 1; Disease Models, Animal; Enzyme Activation; Freund's Adjuvant; Gene Expression Regulation; Hypoglycemic Agents; Inflammation; Interleukin 1 Receptor Antagonist Protein; Interleukin-1beta; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; NF-kappa B; Pain; Pain Threshold; Ribonucleotides; RNA, Small Interfering; Skin

2019
Mechanisms underpinning AMP-activated protein kinase-related effects on behavior and hippocampal neurogenesis in an animal model of depression.
    Neuropharmacology, 2019, 05-15, Volume: 150

    Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Brain-Derived Neurotrophic Factor; Cyclic AMP Response Element-Binding Protein; Depression; Disease Models, Animal; Hindlimb Suspension; Hippocampus; Male; Mice; Neurogenesis; NF-kappa B; Phosphorylation; Ribonucleotides; Signal Transduction

2019
AICAR administration ameliorates hypertension and angiogenic imbalance in a model of preeclampsia in the rat.
    American journal of physiology. Heart and circulatory physiology, 2013, Apr-15, Volume: 304, Issue:8

    Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Blood Pressure; Disease Models, Animal; Female; Heart Rate; Hypertension; Ischemia; Kidney; Neovascularization, Physiologic; Oxidative Stress; Phosphorylation; Placenta; Pre-Eclampsia; Pregnancy; Rats; Rats, Sprague-Dawley; Ribonucleotides; Uterus; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factor Receptor-1

2013
Discovery of N-[5-({2-[(cyclopropylcarbonyl)amino]imidazo[1,2-b]pyridazin-6-yl}oxy)-2-methylphenyl]-1,3-dimethyl-1H-pyrazole-5-carboxamide (TAK-593), a highly potent VEGFR2 kinase inhibitor.
    Bioorganic & medicinal chemistry, 2013, Apr-15, Volume: 21, Issue:8

    Topics: Aminoimidazole Carboxamide; Animals; Disease Models, Animal; Female; Human Umbilical Vein Endothelial Cells; Humans; Macaca fascicularis; Male; Mice; Mice, Inbred AKR; Mice, Nude; Models, Molecular; Protein Kinase Inhibitors; Pyrazoles; Rats; Vascular Endothelial Growth Factor Receptor-2; Xenograft Model Antitumor Assays

2013
AICAR-dependent AMPK activation improves scar formation in the aged heart in a murine model of reperfused myocardial infarction.
    Journal of molecular and cellular cardiology, 2013, Volume: 63

    Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Cicatrix; Disease Models, Animal; Enzyme Activation; Fibroblasts; Male; Mice; Myocardial Infarction; Myocardial Reperfusion Injury; Myofibroblasts; Phosphorylation; Ribonucleotides; Ventricular Remodeling; Wound Healing

2013
Antiplatelet effect of AMP-activated protein kinase activator and its potentiation by the phosphodiesterase inhibitor dipyridamole.
    Biochemical pharmacology, 2013, Oct-01, Volume: 86, Issue:7

    Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Cyclic GMP; Dipyridamole; Disease Models, Animal; Enzyme Activation; Enzyme Activators; Male; Nitric Oxide Synthase Type III; Phosphodiesterase Inhibitors; Phosphorylation; Platelet Aggregation Inhibitors; Rats; Rats, Sprague-Dawley; Ribonucleotides; Signal Transduction; Thrombosis

2013
Depression-like behaviors in mice subjected to co-treatment of high-fat diet and corticosterone are ameliorated by AICAR and exercise.
    Journal of affective disorders, 2014, Volume: 156

    Topics: Aminoimidazole Carboxamide; Animals; Corticosterone; Depression; Depressive Disorder; Diet, High-Fat; Disease Models, Animal; Glucocorticoids; Hypoglycemic Agents; Insulin Resistance; Male; Mice; Mice, Inbred C57BL; Physical Conditioning, Animal; Ribonucleotides

2014
Synergistic anti-tumor activity of acadesine (AICAR) in combination with the anti-CD20 monoclonal antibody rituximab in in vivo and in vitro models of mantle cell lymphoma.
    Oncotarget, 2014, Feb-15, Volume: 5, Issue:3

    Topics: Aminoimidazole Carboxamide; Animals; Antibodies, Monoclonal, Murine-Derived; Antigens, CD20; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Cell Line, Tumor; Cohort Studies; Disease Models, Animal; Drug Synergism; Female; Humans; Lymphoma, Mantle-Cell; Mice; Mice, SCID; Random Allocation; Ribonucleosides; Rituximab; Xenograft Model Antitumor Assays

2014
Mutant TDP-43 deregulates AMPK activation by PP2A in ALS models.
    PloS one, 2014, Volume: 9, Issue:3

    Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Amyotrophic Lateral Sclerosis; Animals; Brain; Cell Line; Disease Models, Animal; DNA-Binding Proteins; Enzyme Activation; Mice, Inbred C57BL; Mice, Transgenic; Motor Neurons; Mutant Proteins; Protein Phosphatase 2; Ribonucleotides; Spinal Cord; Superoxide Dismutase

2014
Thiophene carboxamide inhibitors of JAK2 as potential treatments for myleoproliferative neoplasms.
    Bioorganic & medicinal chemistry letters, 2014, Apr-15, Volume: 24, Issue:8

    Topics: Aminoimidazole Carboxamide; Animals; Antineoplastic Agents; Disease Models, Animal; Enzyme Activation; Humans; Janus Kinase 2; Leukemia, Myeloid, Acute; Microsomes; Models, Biological; Molecular Structure; Protein Kinase Inhibitors; Rats; Thiophenes

2014
Partial hepatic resistance to IL-6-induced inflammation develops in type 2 diabetic mice, while the anti-inflammatory effect of AMPK is maintained.
    Molecular and cellular endocrinology, 2014, Aug-05, Volume: 393, Issue:1-2

    Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Anti-Inflammatory Agents; Blood Glucose; Blotting, Western; Diabetes Mellitus, Type 2; Diet, High-Fat; Disease Models, Animal; Inflammation; Interleukin-6; Liver; Male; Metformin; Mice; Mice, Inbred C57BL; Real-Time Polymerase Chain Reaction; Ribonucleotides

2014
AMPK activation ameliorates Alzheimer's disease-like pathology and spatial memory impairment in a streptozotocin-induced Alzheimer's disease model in rats.
    Journal of Alzheimer's disease : JAD, 2015, Volume: 43, Issue:3

    Topics: Adenylate Kinase; Alzheimer Disease; Aminoimidazole Carboxamide; Animals; Caspase 3; Disease Models, Animal; Hippocampus; Hypoglycemic Agents; Male; Memory Disorders; Phosphorylation; Rats; Rats, Sprague-Dawley; Ribonucleotides; Spatial Memory; Streptozocin; tau Proteins

2015
Utrophin A is essential in mediating the functional adaptations of mdx mouse muscle following chronic AMPK activation.
    Human molecular genetics, 2015, Mar-01, Volume: 24, Issue:5

    Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Disease Models, Animal; Dystroglycans; Female; Genotyping Techniques; Hand Strength; Male; Mice; Mice, Inbred mdx; Mice, Knockout; Muscular Dystrophy, Duchenne; Myofibrils; Phenotype; Ribonucleosides; Utrophin

2015
AMP-activated protein kinase (AMPK) activation inhibits nuclear translocation of Smad4 in mesangial cells and diabetic kidneys.
    American journal of physiology. Renal physiology, 2015, May-15, Volume: 308, Issue:10

    Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Biological Transport; Cell Line; Cell Nucleus; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Disease Models, Animal; Glucose; Hypoglycemic Agents; In Vitro Techniques; Male; Mesangial Cells; Mice; Mice, Inbred C57BL; Ribonucleotides; Signal Transduction; Smad4 Protein; Streptozocin; Transforming Growth Factor beta

2015
Inhibition of AMPK expression in skeletal muscle by systemic inflammation in COPD rats.
    Respiratory research, 2014, Dec-07, Volume: 15

    Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Anti-Inflammatory Agents; Disease Models, Animal; Down-Regulation; Gene Expression Regulation, Enzymologic; Male; Muscle Weakness; Muscle, Skeletal; Pulmonary Disease, Chronic Obstructive; Rats, Wistar; Resveratrol; Ribonucleotides; RNA, Messenger; Sirtuin 1; Stilbenes; Time Factors; Tumor Necrosis Factor-alpha

2014
5-Aminoimidazole-4-carboxamide-1-β-D-ribofuranoside-attenuates LPS/D-Gal-induced acute hepatitis in mice.
    Innate immunity, 2015, Volume: 21, Issue:7

    Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Apoptosis; Caspases; Disease Models, Animal; Galactose; Hepatitis, Animal; Humans; Hypoglycemic Agents; Lipopolysaccharides; Liver; Male; Mice; Molecular Targeted Therapy; Nitric Oxide; Ribonucleotides; Transaminases; Tumor Necrosis Factor-alpha

2015
Effect of Topical 5-Aminoimidazole-4-carboxamide-1-β-d-Ribofuranoside in a Mouse Model of Experimental Dry Eye.
    Investigative ophthalmology & visual science, 2015, Volume: 56, Issue:5

    Topics: Administration, Topical; Aldehydes; Aminoimidazole Carboxamide; Animals; Blotting, Western; Chemokine CXCL9; Disease Models, Animal; Dry Eye Syndromes; Female; Flow Cytometry; Hypoglycemic Agents; Immunohistochemistry; Interferon-gamma; Interleukin-1beta; Mice; Mice, Inbred C57BL; Ophthalmic Solutions; Ribonucleotides; Tears; Tumor Necrosis Factor-alpha

2015
AMP-activated protein kinase attenuates oxLDL uptake in macrophages through PP2A/NF-κB/LOX-1 pathway.
    Vascular pharmacology, 2016, Volume: 85

    Topics: Adenosine; Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Aorta; Apolipoproteins E; Atherosclerosis; Disease Models, Animal; Foam Cells; Lipoproteins, LDL; Macrophages; Mice; Mice, Knockout; NF-kappa B; Okadaic Acid; Protein Phosphatase 2; Ribonucleotides; Scavenger Receptors, Class E

2016
The Role of Nitric Oxide in the Antidepressant Actions of 5-Aminoimidazole-4-Carboxamide-1-β-D-Ribofuranoside in Insulin-Resistant Mice.
    Psychosomatic medicine, 2016, Volume: 78, Issue:1

    Topics: Adenylate Kinase; Aminoimidazole Carboxamide; Animals; Antidepressive Agents; Combined Modality Therapy; Corticosterone; Depressive Disorder; Diet, High-Fat; Disease Models, Animal; Drug Evaluation, Preclinical; Enzyme Activation; Fluoxetine; Imipramine; Insulin Resistance; Ketamine; Male; Mice; Mice, Inbred C57BL; Nerve Tissue Proteins; NG-Nitroarginine Methyl Ester; Nitric Oxide; Physical Conditioning, Animal; Prefrontal Cortex; Ribonucleotides; Triazenes

2016
Chronic Treatment with the AMPK Agonist AICAR Prevents Skeletal Muscle Pathology but Fails to Improve Clinical Outcome in a Mouse Model of Severe Spinal Muscular Atrophy.
    Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics, 2016, Volume: 13, Issue:1

    Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Disease Models, Animal; Female; Male; Mice; Mice, Knockout; Muscle, Skeletal; Muscular Atrophy, Spinal; Ribonucleotides; Spinal Cord; Treatment Outcome

2016
AMPK activation protects from neuronal dysfunction and vulnerability across nematode, cellular and mouse models of Huntington's disease.
    Human molecular genetics, 2016, Mar-15, Volume: 25, Issue:6

    Topics: Adenosine Monophosphate; Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Brain; Caenorhabditis elegans; Cell Death; Corpus Striatum; Disease Models, Animal; Humans; Huntington Disease; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Mutation; Neostriatum; Neurons; Phosphorylation; Ribonucleosides

2016
Permissive role of AMPK and autophagy in adiponectin deficiency-accentuated myocardial injury and inflammation in endotoxemia.
    Journal of molecular and cellular cardiology, 2016, Volume: 93

    Topics: Adiponectin; Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Autophagy; Autophagy-Related Protein-1 Homolog; Calcium; Calcium-Calmodulin-Dependent Protein Kinase Kinase; Cell Death; Disease Models, Animal; Endotoxemia; Lipopolysaccharides; Male; Mice; Mice, Knockout; Myocarditis; Myocardium; Myocytes, Cardiac; Ribonucleotides; Signal Transduction; Sirolimus; TOR Serine-Threonine Kinases; Ventricular Dysfunction

2016
Chronic stress-induced memory deficits are reversed by regular exercise via AMPK-mediated BDNF induction.
    Neuroscience, 2016, Jun-02, Volume: 324

    Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Brain-Derived Neurotrophic Factor; Cells, Cultured; Chronic Disease; Disease Models, Animal; Dose-Response Relationship, Drug; Exercise Therapy; Hippocampus; Male; Maze Learning; Memory Disorders; Mice, Inbred C57BL; Neurogenesis; Nootropic Agents; Restraint, Physical; Ribonucleotides; Running; Stress, Psychological

2016
5-Aminoimidazole-4-carboxamide ribonucleoside-mediated adenosine monophosphate-activated protein kinase activation induces protective innate responses in bacterial endophthalmitis.
    Cellular microbiology, 2016, Volume: 18, Issue:12

    Topics: Acetyl-CoA Carboxylase; Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Anti-Inflammatory Agents, Non-Steroidal; Bacterial Load; Disease Models, Animal; Endophthalmitis; Female; Gene Expression Regulation; Glycolysis; Host-Pathogen Interactions; Immunity, Innate; Intravitreal Injections; Macrophages; MAP Kinase Kinase 4; Mice; Mice, Inbred C57BL; Microglia; NF-kappa B; p38 Mitogen-Activated Protein Kinases; Phagocytosis; Retina; Ribonucleotides; Signal Transduction; Staphylococcal Infections; Staphylococcus aureus

2016
Neuroprotective effect of activated 5'-adenosine monophosphate-activated protein kinase on cone system function during retinal inflammation.
    BMC neuroscience, 2016, 06-10, Volume: 17, Issue:1

    Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Cell Line, Tumor; Disease Models, Animal; Glial Fibrillary Acidic Protein; Lipopolysaccharides; Male; Mice, Inbred C57BL; Mitochondria; Neuroprotective Agents; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; Random Allocation; Retinal Cone Photoreceptor Cells; Retinitis; Ribonucleosides; RNA, Messenger; Tumor Necrosis Factor-alpha

2016
Sustained AMPK activation improves muscle function in a mitochondrial myopathy mouse model by promoting muscle fiber regeneration.
    Human molecular genetics, 2016, 08-01, Volume: 25, Issue:15

    Topics: Alkyl and Aryl Transferases; Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Disease Models, Animal; Enzyme Activation; Membrane Proteins; Mice; Mice, Transgenic; Mitochondria, Muscle; Mitochondrial Myopathies; Muscle Fibers, Skeletal; Regeneration; Ribonucleotides

2016
Targeting deregulated AMPK/mTORC1 pathways improves muscle function in myotonic dystrophy type I.
    The Journal of clinical investigation, 2017, Feb-01, Volume: 127, Issue:2

    Topics: Adult; Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Disease Models, Animal; Female; Humans; Male; Mechanistic Target of Rapamycin Complex 1; Mice; Mice, Mutant Strains; Middle Aged; Multiprotein Complexes; Muscle Fibers, Skeletal; Muscle Relaxation; Myotonic Dystrophy; Myotonin-Protein Kinase; Ribonucleotides; Signal Transduction; Sirolimus; TOR Serine-Threonine Kinases

2017
Age-Dependent Changes in AMPK Metabolic Pathways in the Lung in a Mouse Model of Hemorrhagic Shock.
    American journal of respiratory cell and molecular biology, 2017, Volume: 56, Issue:5

    Topics: Aging; Alveolar Epithelial Cells; Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Autophagy; Blotting, Western; Bronchoalveolar Lavage Fluid; Cell Nucleus; Cytokines; Disease Models, Animal; Enzyme Activation; Hypotension; Lung; Male; Metabolic Networks and Pathways; Mice; Mice, Inbred C57BL; Mitochondria; Neutrophil Infiltration; NF-kappa B; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; Phosphorylation; Protein Transport; Pulmonary Edema; Ribonucleotides; Shock, Hemorrhagic; Sirtuin 1

2017
AMPK activation reduces the number of atheromata macrophages in ApoE deficient mice.
    Atherosclerosis, 2017, Volume: 258

    Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Antigens, Ly; Aorta; Aortic Diseases; Apolipoproteins E; Atherosclerosis; Biphenyl Compounds; Cell Line; Cell Migration Inhibition; Chemotaxis; Disease Models, Animal; Enzyme Activation; Enzyme Activators; Genetic Predisposition to Disease; Humans; Macrophages; Metformin; Mice, Knockout; Phenotype; Pyrones; Receptors, CCR2; Ribonucleotides; Signal Transduction; Thiophenes

2017
Macropinocytosis is decreased in diabetic mouse macrophages and is regulated by AMPK.
    BMC immunology, 2008, Jul-30, Volume: 9

    Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Cell Culture Techniques; Cell Line, Tumor; Diabetes Mellitus, Type 2; Disease Models, Animal; Energy Metabolism; Glucose; Hyperglycemia; Immunity; Leptin; Macrophage Activation; Macrophages, Peritoneal; Mice; Pinocytosis; Pyrazoles; Pyrimidines; Ribonucleosides

2008
Anti-hypertrophic effect of NHE-1 inhibition involves GSK-3beta-dependent attenuation of mitochondrial dysfunction.
    Journal of molecular and cellular cardiology, 2009, Volume: 46, Issue:6

    Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Blotting, Western; Cardiomegaly; Cells, Cultured; Chromones; Disease Models, Animal; Electrophoresis, Polyacrylamide Gel; Endothelin-1; Flavonoids; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Hypoglycemic Agents; Immunoprecipitation; Male; Membrane Potential, Mitochondrial; Microscopy, Confocal; Mitochondrial Membrane Transport Proteins; Mitochondrial Permeability Transition Pore; Morpholines; Myocytes, Cardiac; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Polymerase Chain Reaction; Protein Binding; Proto-Oncogene Proteins c-akt; Rats; Rats, Sprague-Dawley; Ribonucleotides; Sodium-Hydrogen Exchangers; Voltage-Dependent Anion Channels

2009
Hypothalamic AMP-activated protein kinase activation with AICAR amplifies counterregulatory responses to hypoglycemia in a rodent model of type 1 diabetes.
    American journal of physiology. Regulatory, integrative and comparative physiology, 2009, Volume: 296, Issue:6

    Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Blood Glucose; Diabetes Mellitus, Type 1; Disease Models, Animal; Enzyme Activation; Enzyme Activators; Epinephrine; Glucagon; Hypoglycemia; Hypoglycemic Agents; Insulin; Male; Microinjections; Rats; Rats, Inbred BB; Rats, Sprague-Dawley; Ribonucleotides; RNA Interference; RNA, Small Interfering; Time Factors; Ventromedial Hypothalamic Nucleus

2009
C1q tumor necrosis factor alpha-related protein isoform 5 is increased in mitochondrial DNA-depleted myocytes and activates AMP-activated protein kinase.
    The Journal of biological chemistry, 2009, Oct-09, Volume: 284, Issue:41

    Topics: Acetyl-CoA Carboxylase; Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Cell Line; Collagen; Diabetes Mellitus, Type 2; Disease Models, Animal; DNA, Mitochondrial; Enzyme Activation; Fatty Acids; Glucose; Glucose Transporter Type 4; Humans; Insulin Receptor Substrate Proteins; Intracellular Signaling Peptides and Proteins; Male; Membrane Proteins; Mice; Mice, Inbred C57BL; Mice, Obese; Mitochondria; Muscle Cells; p38 Mitogen-Activated Protein Kinases; Proto-Oncogene Proteins c-akt; Rats; Rats, Inbred OLETF; Receptors, Adiponectin; Recombinant Fusion Proteins; Ribonucleotides; RNA, Small Interfering

2009
Cardioprotection with adenosine-regulating agent, GP531: effects on no-reflow, infarct size, and blood flow following ischemia/ reperfusion in the rabbit.
    Journal of cardiovascular pharmacology and therapeutics, 2010, Volume: 15, Issue:1

    Topics: Adenosine; Aminoimidazole Carboxamide; Analysis of Variance; Animals; Deoxyribonucleosides; Disease Models, Animal; Hemodynamics; Male; Myocardial Infarction; Myocardial Ischemia; Myocardial Reperfusion Injury; Rabbits; Random Allocation

2010
Acadesine inhibits tissue factor induction and thrombus formation by activating the phosphoinositide 3-kinase/Akt signaling pathway.
    Arteriosclerosis, thrombosis, and vascular biology, 2010, Volume: 30, Issue:5

    Topics: Adenosine A2 Receptor Antagonists; Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Apolipoproteins E; Atherosclerosis; Blood Coagulation; Cells, Cultured; Disease Models, Animal; Dose-Response Relationship, Drug; Endothelial Cells; Enzyme Activation; Fibrinolytic Agents; Humans; Lipopolysaccharides; Macrophages; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Monocytes; NF-kappa B; Phosphatidylinositol 3-Kinases; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Pyrazoles; Pyrimidines; Receptor, Adenosine A2A; Ribonucleosides; RNA, Messenger; Sepsis; Signal Transduction; Thromboplastin; Transcription Factor AP-1; Triazines; Triazoles; Up-Regulation; Venous Thrombosis

2010
Probing the cannabinoid CB1/CB2 receptor subtype selectivity limits of 1,2-diarylimidazole-4-carboxamides by fine-tuning their 5-substitution pattern.
    Bioorganic & medicinal chemistry letters, 2010, May-01, Volume: 20, Issue:9

    Topics: Administration, Oral; Aminoimidazole Carboxamide; Animals; Disease Models, Animal; Drug Inverse Agonism; Hypotension; Imidazoles; Mice; Rats; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Structure-Activity Relationship; Sulfones

2010
Adenosine monophosphate activated protein kinase regulates ABCG1-mediated oxysterol efflux from endothelial cells and protects against hypercholesterolemia-induced endothelial dysfunction.
    Arteriosclerosis, thrombosis, and vascular biology, 2010, Volume: 30, Issue:7

    Topics: 3' Untranslated Regions; Acetylcholine; Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; ATP Binding Cassette Transporter, Subfamily G, Member 1; ATP-Binding Cassette Transporters; Biological Transport; Cattle; Cells, Cultured; Disease Models, Animal; Dose-Response Relationship, Drug; Endothelial Cells; Endothelium, Vascular; Enzyme Activation; Enzyme Activators; Genes, Reporter; Humans; Hypercholesterolemia; Ketocholesterols; Male; Mice; Mice, Inbred C57BL; Nitric Oxide; Nitric Oxide Synthase Type III; Nitroprusside; Oxidative Stress; Protein Kinase Inhibitors; Pyrazoles; Pyrimidines; Reactive Oxygen Species; Ribonucleotides; RNA Interference; RNA Processing, Post-Transcriptional; RNA Stability; RNA, Messenger; Transfection; Up-Regulation; Vasodilation; Vasodilator Agents

2010
An invertebrate hyperglycemic model for the identification of anti-diabetic drugs.
    PloS one, 2011, Mar-30, Volume: 6, Issue:3

    Topics: Aminoimidazole Carboxamide; Animals; Bombyx; Carbohydrates; Diet; Disease Models, Animal; Drug Evaluation, Preclinical; Feeding Behavior; Galactose; Glucose; Glycation End Products, Advanced; Hemolymph; Humans; Hyperglycemia; Hypoglycemic Agents; Insulin; Ribonucleotides

2011
AMPK activation enhances PPARα activity to inhibit cardiac hypertrophy via ERK1/2 MAPK signaling pathway.
    Archives of biochemistry and biophysics, 2011, Volume: 511, Issue:1-2

    Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Cardiomegaly; Cells, Cultured; Disease Models, Animal; Enzyme Activation; Male; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Myocytes, Cardiac; p38 Mitogen-Activated Protein Kinases; Phosphorylation; PPAR alpha; Rats; Rats, Sprague-Dawley; Ribonucleotides

2011
In vivo correction of COX deficiency by activation of the AMPK/PGC-1α axis.
    Cell metabolism, 2011, Jul-06, Volume: 14, Issue:1

    Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Bezafibrate; Cytochrome-c Oxidase Deficiency; Disease Models, Animal; Electron Transport Complex IV; Gene Knock-In Techniques; Hypoglycemic Agents; Hypolipidemic Agents; Membrane Proteins; Mice; Mice, Knockout; Mice, Transgenic; Mitochondrial Proteins; Molecular Chaperones; Muscle, Skeletal; Oxidative Phosphorylation; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; Ribonucleotides; Signal Transduction; Trans-Activators; Transcription Factors

2011
Inhibitory effect of aminoimidazole carboxamide ribonucleotide (AICAR) on endotoxin-induced uveitis in rats.
    Investigative ophthalmology & visual science, 2011, Aug-22, Volume: 52, Issue:9

    Topics: Aminoimidazole Carboxamide; Animals; Anterior Chamber; Anti-Inflammatory Agents; Aqueous Humor; Blotting, Western; Chemokine CCL2; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Injections, Intraperitoneal; Intercellular Adhesion Molecule-1; Lipopolysaccharide Receptors; Lipopolysaccharides; Male; NF-kappa B; Rats; Rats, Inbred Lew; Retina; Reverse Transcriptase Polymerase Chain Reaction; Ribonucleotides; RNA, Messenger; Salmonella typhimurium; Tumor Necrosis Factor-alpha; Uveitis, Anterior

2011
Chronic AMPK stimulation attenuates adaptive signaling in dystrophic skeletal muscle.
    American journal of physiology. Cell physiology, 2012, Jan-01, Volume: 302, Issue:1

    Topics: Adaptation, Physiological; Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Disease Models, Animal; Mice; Mice, Inbred C57BL; Mice, Inbred mdx; Mice, Transgenic; Muscle, Skeletal; Muscular Dystrophy, Duchenne; Physical Conditioning, Animal; Ribonucleotides; Signal Transduction

2012
AMP-activated protein kinase mediates effects of oxidative stress on embryo gene expression in a mouse model of diabetic embryopathy.
    Diabetologia, 2012, Volume: 55, Issue:1

    Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Antioxidants; Cell Line; Disease Models, Animal; Embryo, Mammalian; Embryonic Stem Cells; Female; Gene Expression Regulation, Developmental; Hyperglycemia; Hypoxia; Mice; Mice, Inbred ICR; Neural Tube Defects; Oxidative Stress; Paired Box Transcription Factors; PAX3 Transcription Factor; Pregnancy; Pregnancy in Diabetics; Protein Kinase Inhibitors; Ribonucleotides; RNA, Messenger

2012
Correction of metabolic abnormalities in a rodent model of obesity, metabolic syndrome, and type 2 diabetes mellitus by inhibitors of hepatic protein kinase C-ι.
    Metabolism: clinical and experimental, 2012, Volume: 61, Issue:4

    Topics: Aminoimidazole Carboxamide; Animals; Blood Glucose; Cholesterol; Diabetes Mellitus, Type 2; Disease Models, Animal; Enzyme Activation; Female; Insulin; Isoenzymes; Liver; Male; Metabolic Syndrome; Mice; Mice, Knockout; Obesity; Protein Kinase C; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Signal Transduction; Triglycerides

2012
Aminoimidazole carboxamide ribonucleotide ameliorates experimental autoimmune uveitis.
    Investigative ophthalmology & visual science, 2012, Jun-28, Volume: 53, Issue:7

    Topics: Aminoimidazole Carboxamide; Animals; Autoimmune Diseases; Blotting, Western; Cell Proliferation; Cytokines; Disease Models, Animal; Female; Flow Cytometry; Hypoglycemic Agents; Immunity, Cellular; Injections, Intraperitoneal; Mice; Mice, Inbred C57BL; Ribonucleotides; T-Lymphocytes; Treatment Outcome; Uvea; Uveitis

2012
AMPK activation reduces vascular permeability and airway inflammation by regulating HIF/VEGFA pathway in a murine model of toluene diisocyanate-induced asthma.
    Inflammation research : official journal of the European Histamine Research Society ... [et al.], 2012, Volume: 61, Issue:10

    Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Asthma; Basic Helix-Loop-Helix Transcription Factors; Bronchoalveolar Lavage Fluid; Capillary Permeability; Cytokines; Disease Models, Animal; Female; Hypoxia-Inducible Factor 1, alpha Subunit; Mice; Mice, Inbred BALB C; Pneumonia; Reactive Oxygen Species; Ribonucleotides; Signal Transduction; Toluene 2,4-Diisocyanate; Vascular Endothelial Growth Factor A

2012
Aberrant endoplasmic reticulum stress in vascular smooth muscle increases vascular contractility and blood pressure in mice deficient of AMP-activated protein kinase-α2 in vivo.
    Arteriosclerosis, thrombosis, and vascular biology, 2013, Volume: 33, Issue:3

    Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Angiotensin II; Animals; Antihypertensive Agents; Blood Pressure; Cells, Cultured; Disease Models, Animal; Dose-Response Relationship, Drug; Endoplasmic Reticulum Stress; Enzyme Activation; Enzyme Activators; Humans; Hypertension; Leupeptins; Mice; Mice, Knockout; Muscle, Smooth, Vascular; Myosin Light Chains; Nitric Oxide Synthase Type III; Phenylbutyrates; Phenylephrine; Phosphorylation; Ribonucleotides; Taurochenodeoxycholic Acid; Time Factors; Tunicamycin; Vasoconstriction; Vasoconstrictor Agents

2013
Attenuation of ischemia-reperfusion injury in a canine model of autologous renal transplantation.
    Transplantation, 2004, Sep-15, Volume: 78, Issue:5

    Topics: Acetylcysteine; Adenosine; Allopurinol; Aminoimidazole Carboxamide; Animals; Apoptosis; Creatinine; Disease Models, Animal; Dogs; Glutathione; Graft Survival; Immunohistochemistry; Insulin; Kidney; Kidney Transplantation; Male; Nephrectomy; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Organ Preservation; Organ Preservation Solutions; Raffinose; Reperfusion Injury; Ribonucleotides; Transplantation, Autologous; Tumor Necrosis Factor-alpha

2004
Pharmacological inhibition of AMP-activated protein kinase provides neuroprotection in stroke.
    The Journal of biological chemistry, 2005, May-27, Volume: 280, Issue:21

    Topics: 4-Butyrolactone; Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Brain Ischemia; Cerebral Cortex; Constriction; Disease Models, Animal; Energy Metabolism; Enzyme Activation; Enzyme Inhibitors; Fatty Acid Synthases; Glucose; Hippocampus; Immunohistochemistry; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Middle Cerebral Artery; Multienzyme Complexes; Nerve Tissue Proteins; Neurons; Neuroprotective Agents; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Oxygen; Protein Serine-Threonine Kinases; Rats; Ribonucleotides; Stroke

2005
Adenosine monophosphate-activated protein kinase and nitric oxide in rat steatotic liver transplantation.
    Journal of hepatology, 2005, Volume: 43, Issue:6

    Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Disease Models, Animal; Enzyme Activators; Enzyme Inhibitors; Fatty Liver; Ischemic Preconditioning; Liver; Liver Transplantation; Multienzyme Complexes; Nitric Oxide; Nitric Oxide Synthase; Oxidative Stress; Protein Serine-Threonine Kinases; Rats; Rats, Zucker; Reperfusion Injury; Ribonucleotides; Vidarabine

2005
5-aminoimidazole-4-carboxamide-1-beta-4-ribofuranoside attenuates experimental autoimmune encephalomyelitis via modulation of endothelial-monocyte interaction.
    Journal of neuroscience research, 2006, Aug-15, Volume: 84, Issue:3

    Topics: Aminoimidazole Carboxamide; Animals; Anti-Inflammatory Agents; Blood-Brain Barrier; Cell Adhesion; Cell Adhesion Molecules; Chemotaxis, Leukocyte; Disease Models, Animal; Down-Regulation; Encephalomyelitis, Autoimmune, Experimental; Endothelial Cells; Female; Inflammation Mediators; Mice; Monocytes; NF-kappa B; Rats; Rats, Inbred Lew; Ribonucleotides; Tumor Necrosis Factor-alpha

2006
Long-term activation of adenosine monophosphate-activated protein kinase attenuates pressure-overload-induced cardiac hypertrophy.
    Journal of cellular biochemistry, 2007, Apr-01, Volume: 100, Issue:5

    Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Animals, Newborn; Calcineurin; Cardiomegaly; Cells, Cultured; Disease Models, Animal; Enzyme Activation; Gene Expression Regulation, Enzymologic; Hypoglycemic Agents; Male; Mitogen-Activated Protein Kinases; Multienzyme Complexes; Myocytes, Cardiac; NF-kappa B; Phosphorylation; Protein Serine-Threonine Kinases; Rats; Rats, Sprague-Dawley; Ribonucleotides; Signal Transduction; Ventricular Pressure

2007
Acadesine extends the window of protection afforded by ischaemic preconditioning in conscious rabbits.
    Cardiovascular research, 1995, Volume: 29, Issue:5

    Topics: Adenosine; Aminoimidazole Carboxamide; Animals; Disease Models, Animal; Myocardial Infarction; Myocardial Ischemia; Myocardial Reperfusion; Myocardium; Rabbits; Ribonucleosides; Time Factors; Ventricular Fibrillation

1995
Resuscitation of hemorrhagic shock with hypertonic saline/dextran or lactated Ringer's supplemented with AICA riboside.
    Circulatory shock, 1993, Volume: 40, Issue:1

    Topics: Aminoimidazole Carboxamide; Animals; Buffers; Dextrans; Disease Models, Animal; Female; Hemodynamics; Hypertonic Solutions; Lactates; Male; Oxygen Consumption; Reperfusion Injury; Ribonucleosides; Shock, Hemorrhagic; Sodium Chloride; Swine

1993
Acadesine improves tolerance to ischemic injury in rat cardiac myocytes.
    Journal of molecular and cellular cardiology, 1994, Volume: 26, Issue:9

    Topics: Aminoimidazole Carboxamide; Animals; Disease Models, Animal; Female; Heart; In Vitro Techniques; Myocardial Contraction; Myocardial Reperfusion Injury; Purinergic P1 Receptor Antagonists; Rats; Rats, Sprague-Dawley; Ribonucleosides; Theophylline

1994
Adenosine-mediated inhibition of platelet aggregation by acadesine. A novel antithrombotic mechanism in vitro and in vivo.
    The Journal of clinical investigation, 1994, Volume: 94, Issue:4

    Topics: Adenosine; Adenosine Deaminase; Adenosine Kinase; Aminoimidazole Carboxamide; Animals; Aspirin; Blood Physiological Phenomena; Coronary Thrombosis; Coronary Vessels; Dipyridamole; Disease Models, Animal; Dogs; Erythrocytes; Humans; Male; Plasma; Platelet Aggregation; Purinergic P1 Receptor Antagonists; Regional Blood Flow; Ribonucleosides; Theophylline; Tubercidin

1994
Timely administration of AICA riboside reduces reperfusion injury in rabbits.
    Cardiovascular research, 1994, Volume: 28, Issue:7

    Topics: Aminoimidazole Carboxamide; Animals; Autoradiography; Disease Models, Animal; Male; Myocardial Infarction; Myocardial Reperfusion Injury; Myocardium; Rabbits; Ribonucleosides; Tetrazolium Salts

1994
The antiinflammatory mechanism of methotrexate. Increased adenosine release at inflamed sites diminishes leukocyte accumulation in an in vivo model of inflammation.
    The Journal of clinical investigation, 1993, Volume: 92, Issue:6

    Topics: Adenosine; Adenosine Deaminase; Aminoimidazole Carboxamide; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Disease Models, Animal; Female; Inflammation; Kinetics; Leukocytes; Methotrexate; Mice; Mice, Inbred BALB C; Purinergic P1 Receptor Antagonists; Ribonucleotides; Spleen; Theobromine; Time Factors

1993
The anti-inflammatory mechanism of sulfasalazine is related to adenosine release at inflamed sites.
    Journal of immunology (Baltimore, Md. : 1950), 1996, Mar-01, Volume: 156, Issue:5

    Topics: Acyltransferases; Adenosine; Aminoimidazole Carboxamide; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Disease Models, Animal; Endothelium, Vascular; Female; Humans; Hydroxymethyl and Formyl Transferases; Mice; Mice, Inbred BALB C; Neutrophil Activation; Phosphoribosylaminoimidazolecarboxamide Formyltransferase; Ribonucleotides; Sulfasalazine

1996
Endogenous adenosine and secondary injury after chest trauma.
    The Journal of trauma, 2000, Volume: 49, Issue:5

    Topics: Acidosis; Adenosine; Aminoimidazole Carboxamide; Animals; Bronchoalveolar Lavage Fluid; Disease Models, Animal; Drug Evaluation, Preclinical; Hemodynamics; Hypercapnia; Inflammation; Leukocyte Count; Peroxidase; Ribonucleosides; Survival Analysis; Swine; Thoracic Injuries; Wounds, Nonpenetrating

2000
Acadesine and intestinal barrier function after hemorrhagic shock and resuscitation.
    Critical care medicine, 2000, Volume: 28, Issue:12

    Topics: Adenosine; Adenosine Kinase; Aminoimidazole Carboxamide; Animals; Blood Flow Velocity; Capillary Permeability; Disease Models, Animal; Drug Evaluation, Preclinical; Female; Fluid Therapy; Formycins; Ileum; Intestinal Mucosa; Ischemia; Laser-Doppler Flowmetry; Male; Resuscitation; Ribonucleosides; Shock, Hemorrhagic; Swine

2000
Combination therapy that targets secondary pulmonary changes after abdominal trauma.
    Shock (Augusta, Ga.), 2001, Volume: 15, Issue:6

    Topics: Abdominal Abscess; Abdominal Injuries; Aminoimidazole Carboxamide; Animals; Anti-Inflammatory Agents; Blood Pressure; Capillaries; Disease Models, Animal; Hemodynamics; Inflammation; Lactates; Lung; Lung Injury; Neutrophils; Pulmonary Alveoli; Pulmonary Artery; Resuscitation; Ribonucleotides; Shock, Hemorrhagic; Steroids; Swine

2001
5-aminoimidazole-4-carboxy-amide-1-beta-D-ribofuranoside treatment ameliorates hyperglycaemia and hyperinsulinaemia but not dyslipidaemia in KKAy-CETP mice.
    Diabetologia, 2001, Volume: 44, Issue:12

    Topics: Aminoimidazole Carboxamide; Animals; Carrier Proteins; Cholesterol Ester Transfer Proteins; Diabetes Mellitus, Type 2; Disease Models, Animal; Female; Glucose; Glycoproteins; Hyperglycemia; Hyperinsulinism; Hyperlipidemias; Hypoglycemic Agents; Mice; Mice, Transgenic; Muscle, Skeletal; Ribonucleotides

2001
Morphological and biochemical studies on the effect of agents with liver protecting properties.
    Experimentelle Pathologie, 1978, Volume: 15, Issue:5

    Topics: Acetamides; Aminoimidazole Carboxamide; Animals; Carbon Tetrachloride Poisoning; Disease Models, Animal; Female; Imidazoles; Liver; Liver Cirrhosis, Experimental; Male; Rats; Thioacetamide

1978