aminoimidazole carboxamide has been researched along with Diabetes Mellitus, Adult-Onset in 36 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 19 (52.78) | 29.6817 |
| 2010's | 15 (41.67) | 24.3611 |
| 2020's | 2 (5.56) | 2.80 |
| Authors | Studies |
|---|---|
| An, ZN; Ge, MH; Jiang, DW; Liu, C; Shen, XL; Wei, DZ; Xing, XJ; Zheng, DM | 1 |
| Hinkle, JS; Rivera, CN; Vaughan, RA | 1 |
| Cao, L; Ji, L; Li, H; Mao, K; Sha, L; Tang, X; Wei, J; Wei, N; Wu, J; Xie, W; Yang, S; Yang, Z; Zhu, L | 1 |
| Fleming, TH; Groener, JB; Kopf, S; Mendler, M; Nawroth, PP; Okun, JG; Riedinger, C | 1 |
| Chibalin, AV; Dolinar, K; Jan, V; Pavlin, M; Pirkmajer, S | 1 |
| Foglia, B; Montessuit, C; Viglino, C | 1 |
| Ichihara, K; Satoh, K; Shibata, T; Takaguri, A | 1 |
| Al-Hasani, H; Chadt, A; Dokas, J; Himmelbauer, H; Joost, HG; Nolden, T; Zierath, JR | 1 |
| Farese, RV; Ivey, RA; Sajan, MP | 1 |
| Inaba, T; Ito, A; Kawashima, M; Morimoto, K; Sano, K; Tsubota, K; Watanabe, M | 1 |
| Ahima, RS; Bang, S; Chen, Y; Kim, SF | 1 |
| Amrutkar, M; Cansby, E; Durán, EN; Mahlapuu, M; Nerstedt, A; Smith, U | 1 |
| Asahara, S; Bartolome, A; Inoue, H; Kanno, A; Kawamoto, T; Kido, Y; Koyanagi-Kimura, M; Matsuda, T; Matsuura, Y; Mieda, Y; Ogawa, W; Seino, S; Shimizu, S; Suzuki, E; Takahashi, H; Takai, T; Yokoi, N | 1 |
| Chibalin, AV; Hiukka, A; Koistinen, HA; Kuoppamaa, H; Sihvo, M; Skrobuk, P; Zierath, JR | 1 |
| Chakour, KS; Freund, GG; Guest, CB | 1 |
| Winder, WW | 2 |
| Blaak, EE; Boon, H; Bosselaar, M; Hargreaves, M; McGee, SL; Praet, SF; Saris, WH; Smits, P; Tack, CJ; van Loon, LJ; Wagenmakers, AJ | 1 |
| Babraj, JA; Chen, S; Cuthbertson, DJ; Green, K; Hardie, DG; Leese, G; Mustard, K; Rennie, MJ; Smith, K; Sutherland, C; Towler, MC | 1 |
| Hawley, JA; Holloszy, JO | 1 |
| Bala, M; Buechler, C; Kopp, A; Lieberer, E; Neumeier, M; Schäffler, A; Sporrer, D; Stögbauer, F; Wanninger, J; Weber, M; Weigert, J | 1 |
| Choi, JH; Lee, HK; Lee, W; Pak, YK; Park, KS; Park, SY; Ryu, HS | 1 |
| Bala, M; Buechler, C; Kopp, A; Neumeier, M; Schäffler, A; Sporrer, D; Stögbauer, F; Wanninger, J; Weber, M; Weigert, J; Wurm, S | 1 |
| Li, L; Tao, HL; Wang, XF; Zhang, JY; Zhang, L; Zhao, XY | 1 |
| Aguer, C; Foretz, M; Hébrard, S; Kitzmann, M; Lantier, L; Mercier, J | 1 |
| Aguer, C; Foretz, M; Hebrard, S; Kitzmann, M; Lantier, L; Mercier, J; Viollet, B | 1 |
| Acevedo-Duncan, M; Braun, U; Farese, RV; Fields, AP; Kahn, CR; Leitges, M; Mastorides, S; Nimal, S; Sajan, MP | 1 |
| Goodyear, LJ; Musi, N | 1 |
| Chibalin, AV; Galuska, D; Holman, GD; Koistinen, HA; Wallberg-Henriksson, H; Yang, J; Zierath, JR | 1 |
| Chibalin, AV; Koistinen, HA; Zierath, JR | 1 |
| Long, YC; Zierath, JR | 1 |
| Choudhury, GG; Feliers, D; Foretz, M; Kasinath, BS; Lee, MJ; Mahimainathan, L; Mariappan, MM; Musi, N; Sataranatarajan, K; Viollet, B; Weinberg, JM | 1 |
| Goodyear, LJ; Taylor, EB | 1 |
| Chen, Y; Doebber, T; Fenyk-Melody, J; Fujii, N; Goodyear, LJ; Hirshman, MF; Li, Y; Moller, DE; Musi, N; Myers, R; Shen, X; Ventre, J; Wu, M; Zhou, G | 1 |
| Fiedler, M; Liang, Y; Sakariassen, KS; Selén, G; Wallberg-Henriksson, H; Zierath, JR | 1 |
| Chibalin, AV; Fernström, M; Fiedler, M; Galuska, D; Ryder, JW; Song, XM; Wallberg-Henriksson, H; Zierath, JR | 1 |
3 review(s) available for aminoimidazole carboxamide and Diabetes Mellitus, Adult-Onset
| Article | Year |
|---|---|
Exercise: it's the real thing!
Topics: Aminoimidazole Carboxamide; Animals; Cardiovascular Diseases; Diabetes Mellitus, Type 2; Energy Intake; Exercise; Gene Expression; Humans; Life Style; Mitochondria, Muscle; Muscle, Skeletal; Obesity; PPAR delta; Primary Prevention; Ribonucleotides | 2009 |
Targeting the AMP-activated protein kinase for the treatment of type 2 diabetes.
Topics: Adipose Tissue; Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Diabetes Mellitus, Type 2; Enzyme Activators; Exercise; Glucose; Humans; Hypoglycemic Agents; Insulin; Multienzyme Complexes; Muscle Contraction; Muscle, Skeletal; Protein Serine-Threonine Kinases; Ribonucleosides | 2002 |
AMP-activated protein kinase: possible target for treatment of type 2 diabetes.
Topics: Adenosine Monophosphate; Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Diabetes Mellitus, Type 2; Enzyme Activation; Glucose Transporter Type 4; Humans; Insulin; Monosaccharide Transport Proteins; Multienzyme Complexes; Muscle Contraction; Muscle Proteins; Muscle, Skeletal; Protein Serine-Threonine Kinases; Rats; Ribonucleotides | 2000 |
2 trial(s) available for aminoimidazole carboxamide and Diabetes Mellitus, Adult-Onset
| Article | Year |
|---|---|
Urine levels of 5-aminoimidazole-4-carboxamide riboside (AICAR) in patients with type 2 diabetes.
Topics: Adenylate Kinase; Adult; Aged; Aminoimidazole Carboxamide; Animals; Case-Control Studies; Cohort Studies; Diabetes Complications; Diabetes Mellitus, Type 2; Female; Humans; Male; Middle Aged; Prediabetic State; Ribonucleotides; Risk Factors; Risk Reduction Behavior; Signal Transduction | 2018 |
Intravenous AICAR administration reduces hepatic glucose output and inhibits whole body lipolysis in type 2 diabetic patients.
Topics: Aminoimidazole Carboxamide; Blood Glucose; Diabetes Mellitus, Type 2; Glucose; Humans; Hypoglycemic Agents; Injections, Intravenous; Lipolysis; Liver; Male; Middle Aged; Ribonucleotides; Treatment Outcome | 2008 |
31 other study(ies) available for aminoimidazole carboxamide and Diabetes Mellitus, Adult-Onset
| Article | Year |
|---|---|
Medium & long-chain acylcarnitine's relation to lipid metabolism as potential predictors for diabetic cardiomyopathy: a metabolomic study.
Topics: Adult; Aminoimidazole Carboxamide; Animals; Biomarkers; Carnitine; Cell Line; Diabetes Mellitus, Type 2; Diabetic Cardiomyopathies; Female; Humans; Lipid Metabolism; Male; Mass Spectrometry; Middle Aged; Myoblasts, Cardiac; Myristic Acids; Rats; Retrospective Studies; Ribonucleosides; Risk Factors | 2021 |
AICAR stimulates mitochondrial biogenesis and BCAA catabolic enzyme expression in C2C12 myotubes.
Topics: 3-Methyl-2-Oxobutanoate Dehydrogenase (Lipoamide); Amino Acids, Branched-Chain; Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Diabetes Mellitus, Type 2; Humans; Muscle Fibers, Skeletal; Muscle, Skeletal; Organelle Biogenesis; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; Ribonucleotides | 2022 |
Insulin degrading enzyme contributes to the pathology in a mixed model of Type 2 diabetes and Alzheimer's disease: possible mechanisms of IDE in T2D and AD.
Topics: Alzheimer Disease; Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Amyloid beta-Peptides; Animals; Blood Glucose; Diabetes Mellitus, Type 2; Disease Models, Animal; Fasting; Gene Expression Regulation; Glucose Tolerance Test; Humans; Insulin; Insulysin; Learning; Mice; Mice, Transgenic; PPAR gamma; Ribonucleotides; Rosiglitazone; Streptozocin; Thiazolidinediones | 2018 |
Nucleosides block AICAR-stimulated activation of AMPK in skeletal muscle and cancer cells.
Topics: Adenosine; Aminoimidazole Carboxamide; AMP-Activated Protein Kinase Kinases; Ascorbic Acid; Cell Line, Tumor; Culture Media; Diabetes Mellitus, Type 2; Energy Metabolism; Glucose; Humans; Muscle, Skeletal; Neoplasms; Nucleosides; Protein Kinases; Ribonucleotides; Thioctic Acid; Vitamin B 12 | 2018 |
Chronic AICAR treatment prevents metabolic changes in cardiomyocytes exposed to free fatty acids.
Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Biological Transport; Diabetes Mellitus, Type 2; Fatty Acids, Nonesterified; Glucose; Glycolysis; Hypoglycemic Agents; Male; Myocytes, Cardiac; Phosphorylation; Rats; Rats, Sprague-Dawley; Ribonucleotides | 2019 |
Inhibition of the TNF-α-induced serine phosphorylation of IRS-1 at 636/639 by AICAR.
Topics: 3T3-L1 Cells; Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Cells, Cultured; Diabetes Mellitus, Type 2; Dual-Specificity Phosphatases; Extracellular Signal-Regulated MAP Kinases; Hypoglycemic Agents; Injections, Intraperitoneal; Insulin Receptor Substrate Proteins; Insulin Resistance; Mice; Mice, Inbred Strains; Mitogen-Activated Protein Kinase Phosphatases; Phosphorylation; Ribonucleotides; Serine; Signal Transduction; Stimulation, Chemical; Tumor Necrosis Factor-alpha | 2013 |
Conventional knockout of Tbc1d1 in mice impairs insulin- and AICAR-stimulated glucose uptake in skeletal muscle.
Topics: Aminoimidazole Carboxamide; Animals; Anti-Obesity Agents; Biological Transport; Carbon Dioxide; Diabetes Mellitus, Type 2; Disease Susceptibility; Energy Metabolism; Glucose; GTPase-Activating Proteins; Hypertriglyceridemia; Hypoglycemic Agents; Insulin Resistance; Lipid Metabolism; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Mice, Mutant Strains; Muscle, Skeletal; Nuclear Proteins; Obesity; Oxygen Consumption; Ribonucleotides | 2013 |
Metformin action in human hepatocytes: coactivation of atypical protein kinase C alters 5'-AMP-activated protein kinase effects on lipogenic and gluconeogenic enzyme expression.
Topics: Adult; Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Blotting, Western; Cells, Cultured; Diabetes Mellitus, Type 2; Female; Hepatocytes; Humans; Isoenzymes; Liver; Male; Metformin; Middle Aged; Protein Kinase C; Ribonucleotides | 2013 |
Aerobic exercise increases tear secretion in type 2 diabetic mice.
Topics: Aminoimidazole Carboxamide; Animals; Blood Glucose; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Dose-Response Relationship, Drug; Female; Hypoglycemic Agents; Injections, Intraperitoneal; Mice; Mice, Inbred C57BL; Oxidative Stress; Physical Conditioning, Animal; Ribonucleotides; Tears | 2014 |
Convergence of IPMK and LKB1-AMPK signaling pathways on metformin action.
Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Cell Line, Tumor; Diabetes Mellitus, Type 2; Energy Metabolism; Fatty Acids; Gene Knockout Techniques; Gluconeogenesis; Glucose; HEK293 Cells; HeLa Cells; Humans; Hypoglycemic Agents; Lipid Metabolism; Liver; Metformin; Mice; Oxidation-Reduction; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Protein Serine-Threonine Kinases; Ribonucleotides | 2014 |
Partial hepatic resistance to IL-6-induced inflammation develops in type 2 diabetic mice, while the anti-inflammatory effect of AMPK is maintained.
Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Anti-Inflammatory Agents; Blood Glucose; Blotting, Western; Diabetes Mellitus, Type 2; Diet, High-Fat; Disease Models, Animal; Inflammation; Interleukin-6; Liver; Male; Metformin; Mice; Mice, Inbred C57BL; Real-Time Polymerase Chain Reaction; Ribonucleotides | 2014 |
Regulation of Pancreatic β Cell Mass by Cross-Interaction between CCAAT Enhancer Binding Protein β Induced by Endoplasmic Reticulum Stress and AMP-Activated Protein Kinase Activity.
Topics: Adamantane; Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; CCAAT-Enhancer-Binding Protein-beta; Cell Line; Diabetes Mellitus, Type 2; Endoplasmic Reticulum Stress; Gene Expression Regulation; Glucose Tolerance Test; Hypoglycemic Agents; Insulin-Secreting Cells; Islets of Langerhans; Metformin; Mice; Mice, Inbred C57BL; Mice, Transgenic; Nitriles; Phosphorylation; Pyrrolidines; Ribonucleotides; Vildagliptin | 2015 |
Globular adiponectin stimulates glucose transport in type 2 diabetic muscle.
Topics: Adenylate Kinase; Adiponectin; Aminoimidazole Carboxamide; Cohort Studies; Diabetes Mellitus, Type 2; Glucose; GTPase-Activating Proteins; Humans; Insulin; Male; Middle Aged; Muscle, Skeletal; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Proto-Oncogene Proteins c-akt; Receptors, Adiponectin; Ribonucleotides | 2008 |
Macropinocytosis is decreased in diabetic mouse macrophages and is regulated by AMPK.
Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Cell Culture Techniques; Cell Line, Tumor; Diabetes Mellitus, Type 2; Disease Models, Animal; Energy Metabolism; Glucose; Hyperglycemia; Immunity; Leptin; Macrophage Activation; Macrophages, Peritoneal; Mice; Pinocytosis; Pyrazoles; Pyrimidines; Ribonucleosides | 2008 |
Can patients with type 2 diabetes be treated with 5'-AMP-activated protein kinase activators?
Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Blood Glucose; Diabetes Mellitus, Type 2; Enzyme Activation; Humans; Hypoglycemic Agents; Models, Biological; Ribonucleotides | 2008 |
Blunting of AICAR-induced human skeletal muscle glucose uptake in type 2 diabetes is dependent on age rather than diabetic status.
Topics: Acetyl-CoA Carboxylase; Age Factors; Aminoimidazole Carboxamide; AMP-Activated Protein Kinase Kinases; Biopsy; Blood Glucose; Deoxyglucose; Diabetes Mellitus, Type 2; GTPase-Activating Proteins; Humans; Hypoglycemic Agents; Insulin; Male; Middle Aged; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Muscle, Skeletal; Phosphorylation; Protein Kinases; Ribonucleotides; Young Adult | 2009 |
Adiponectin downregulates CD163 whose cellular and soluble forms are elevated in obesity.
Topics: Adiponectin; Adult; Aminoimidazole Carboxamide; Antigens, CD; Antigens, Differentiation, Myelomonocytic; Diabetes Mellitus, Type 2; Down-Regulation; Enzyme-Linked Immunosorbent Assay; Female; Humans; Hypoglycemic Agents; Male; Metformin; Middle Aged; Obesity; Receptors, Cell Surface; Ribonucleotides | 2009 |
C1q tumor necrosis factor alpha-related protein isoform 5 is increased in mitochondrial DNA-depleted myocytes and activates AMP-activated protein kinase.
Topics: Acetyl-CoA Carboxylase; Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Cell Line; Collagen; Diabetes Mellitus, Type 2; Disease Models, Animal; DNA, Mitochondrial; Enzyme Activation; Fatty Acids; Glucose; Glucose Transporter Type 4; Humans; Insulin Receptor Substrate Proteins; Intracellular Signaling Peptides and Proteins; Male; Membrane Proteins; Mice; Mice, Inbred C57BL; Mice, Obese; Mitochondria; Muscle Cells; p38 Mitogen-Activated Protein Kinases; Proto-Oncogene Proteins c-akt; Rats; Rats, Inbred OLETF; Receptors, Adiponectin; Recombinant Fusion Proteins; Ribonucleotides; RNA, Small Interfering | 2009 |
Adiponectin downregulates galectin-3 whose cellular form is elevated whereas its soluble form is reduced in type 2 diabetic monocytes.
Topics: Adiponectin; Adult; Aged; Aged, 80 and over; Aminoimidazole Carboxamide; Body Mass Index; Cells, Cultured; Cholesterol; Diabetes Mellitus, Type 2; Dose-Response Relationship, Drug; Enzyme-Linked Immunosorbent Assay; Galectin 3; Humans; Immunoblotting; Male; Metformin; Middle Aged; Monocytes; Oleic Acid; Palmitic Acid; Pyrazoles; Pyrimidines; Reverse Transcriptase Polymerase Chain Reaction; Ribonucleotides; Solubility; Time Factors | 2009 |
Metformin improves cardiac function in rats via activation of AMP-activated protein kinase.
Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Blood Glucose; Diabetes Mellitus, Type 2; Echocardiography; Heart Failure; Hypoglycemic Agents; Insulin; Male; Metformin; Myocardium; Natriuretic Peptide, Brain; Nitric Oxide Synthase Type III; Random Allocation; Rats; Rats, Wistar; Ribonucleotides; Ventricular Function, Left; Ventricular Remodeling | 2011 |
Abnormal metabolism flexibility in response to high palmitate concentrations in myotubes derived from obese type 2 diabetic patients.
Topics: Acetyl-CoA Carboxylase; Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Cells, Cultured; Diabetes Mellitus, Type 2; Humans; Hypoglycemic Agents; Lipid Metabolism; Metformin; Middle Aged; Mitochondria; Muscle Fibers, Skeletal; Obesity; Oxidation-Reduction; Palmitates; Phosphorylation; Quadriceps Muscle; Ribonucleotides | 2011 |
Increased FAT/CD36 cycling and lipid accumulation in myotubes derived from obese type 2 diabetic patients.
Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Cadherins; Cell Differentiation; Diabetes Mellitus, Type 2; Endocytosis; Enzyme Activation; Humans; Insulin; Lipid Metabolism; Membrane Microdomains; Middle Aged; Muscle Fibers, Skeletal; Oxidation-Reduction; Protein Transport; Ribonucleotides | 2011 |
Correction of metabolic abnormalities in a rodent model of obesity, metabolic syndrome, and type 2 diabetes mellitus by inhibitors of hepatic protein kinase C-ι.
Topics: Aminoimidazole Carboxamide; Animals; Blood Glucose; Cholesterol; Diabetes Mellitus, Type 2; Disease Models, Animal; Enzyme Activation; Female; Insulin; Isoenzymes; Liver; Male; Metabolic Syndrome; Mice; Mice, Knockout; Obesity; Protein Kinase C; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Signal Transduction; Triglycerides | 2012 |
5-amino-imidazole carboxamide riboside increases glucose transport and cell-surface GLUT4 content in skeletal muscle from subjects with type 2 diabetes.
Topics: Aminoimidazole Carboxamide; Biological Transport; Body Mass Index; Diabetes Mellitus, Type 2; Glucose; Glucose Transporter Type 4; Humans; Hypoglycemic Agents; In Vitro Techniques; Insulin; Middle Aged; Monosaccharide Transport Proteins; Muscle Proteins; Muscle, Skeletal; Oxygen Consumption; Reference Values; Ribonucleotides | 2003 |
Aberrant p38 mitogen-activated protein kinase signalling in skeletal muscle from Type 2 diabetic patients.
Topics: Aminoimidazole Carboxamide; Case-Control Studies; Diabetes Mellitus, Type 2; Humans; Hypoglycemic Agents; Insulin; Middle Aged; Mitogen-Activated Protein Kinases; Muscle, Skeletal; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Ribonucleotides; Signal Transduction | 2003 |
Fine-tuning insulin and nitric oxide signalling by turning up the AMPs: new insights into AMP-activated protein kinase signalling.
Topics: Adenosine Monophosphate; Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Diabetes Mellitus, Type 2; Enzyme Activation; Glucose; Insulin; Male; Multienzyme Complexes; Myocardium; Nitric Oxide; Nitric Oxide Donors; Nitroprusside; Phosphatidylinositol 3-Kinases; Phosphorylation; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins c-akt; Rats; Rats, Sprague-Dawley; Ribonucleotides; Signal Transduction | 2005 |
A role for AMP-activated protein kinase in diabetes-induced renal hypertrophy.
Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Carrier Proteins; Cells, Cultured; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Glucose; Hypertrophy; Intracellular Signaling Peptides and Proteins; Kidney; Metformin; Multienzyme Complexes; Phosphoproteins; Protein Serine-Threonine Kinases; Rats; Ribonucleosides; Transforming Growth Factor beta | 2007 |
Targeting skeletal muscle AMP-activated protein kinase to treat type 2 diabetes.
Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Diabetes Mellitus, Type 2; Enzyme Activation; Enzyme Activators; Humans; Hypoglycemic Agents; Mice; Multienzyme Complexes; Muscle, Skeletal; Protein Serine-Threonine Kinases; Protein Subunits; Ribonucleotides | 2007 |
Role of AMP-activated protein kinase in mechanism of metformin action.
Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; CCAAT-Enhancer-Binding Proteins; Diabetes Mellitus, Type 2; DNA-Binding Proteins; Enzyme Activation; Fatty Acids; Gene Expression; Glucose; Hepatocytes; Humans; Hypoglycemic Agents; In Vitro Techniques; Male; Metformin; Multienzyme Complexes; Muscle, Skeletal; Protein Kinase Inhibitors; Protein Kinases; Protein Serine-Threonine Kinases; Pyrazoles; Pyrimidines; Rats; Rats, Sprague-Dawley; Ribonucleotides; RNA, Messenger; Sterol Regulatory Element Binding Protein 1; Transcription Factors | 2001 |
5-aminoimidazole-4-carboxy-amide-1-beta-D-ribofuranoside treatment ameliorates hyperglycaemia and hyperinsulinaemia but not dyslipidaemia in KKAy-CETP mice.
Topics: Aminoimidazole Carboxamide; Animals; Carrier Proteins; Cholesterol Ester Transfer Proteins; Diabetes Mellitus, Type 2; Disease Models, Animal; Female; Glucose; Glycoproteins; Hyperglycemia; Hyperinsulinism; Hyperlipidemias; Hypoglycemic Agents; Mice; Mice, Transgenic; Muscle, Skeletal; Ribonucleotides | 2001 |
5-Aminoimidazole-4-carboxamide ribonucleoside treatment improves glucose homeostasis in insulin-resistant diabetic (ob/ob) mice.
Topics: Aminoimidazole Carboxamide; Animals; Biological Transport; Blood Glucose; Diabetes Mellitus; Diabetes Mellitus, Type 2; Glucose; Glucose Tolerance Test; Glycogen; Homeostasis; Hypoglycemic Agents; Injections, Subcutaneous; Insulin; Insulin Resistance; Liver; Liver Glycogen; Mice; Mice, Inbred C57BL; Mice, Obese; Muscle, Skeletal; Obesity; Ribonucleotides | 2002 |