aminoglutethimide has been researched along with Uterine Neoplasms in 9 studies
Aminoglutethimide: An aromatase inhibitor that is used in the treatment of advanced BREAST CANCER.
aminoglutethimide : A dicarboximide that is a six-membered cyclic compound having ethyl and 4-aminophenyl substituents at the 3-position.
Uterine Neoplasms: Tumors or cancer of the UTERUS.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Additionally, compound 2 inhibited androstenedione-induced uterine hypertrophy in sexually immature mice (41% of uterine weight suppression for compound 2 versus 51% for AG)." | 3.71 | Aromatase inhibition by an 11,13-dihydroderivative of a sesquiterpene lactone. ( Blanco, JG; Bocco, JL; Flury, A; Genti-Raimondi, S; Gil, RR; Meragelman, TL, 2001) |
| " There is a tendency towards an increased response-rate with increased dosage of progestin, in both endometrial and breast carcinoma, while the route of administration appears to be of minor importance." | 2.37 | Progestin therapy of endometrial, breast and ovarian carcinoma. A review of clinical observations. ( Kauppila, A, 1984) |
| "These findings suggest that in molar pregnancy the decreased capacity of trophoblast tissue for the formation of estrogen could increase the testosterone concentration inside the molar vesicle, which, in turn, as we previously reported, inhibits progesterone formation." | 1.29 | Low aromatase activity in microsomes from complete hydatidiform mole. ( Alvarez, CI; Flury, A; Genti-Raimondi, S; Patrito, LC, 1993) |
| "Aminoglutethimide (AG) has recently been introduced for endocrine therapy in patients with advanced breast and endometrial cancer." | 1.27 | Aminoglutethimide and warfarin. A new important drug interaction. ( Jahren, G; Kvinnsland, S; Lønning, PE, 1984) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 7 (77.78) | 18.7374 |
| 1990's | 1 (11.11) | 18.2507 |
| 2000's | 1 (11.11) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Schulz, KD | 1 |
| Kaiser, R | 1 |
| Kauppila, A | 1 |
| Lønning, PE | 1 |
| Kvinnsland, S | 1 |
| Jahren, G | 1 |
| Quinn, MA | 2 |
| Campbell, JJ | 1 |
| Murray, R | 1 |
| Pepperell, RJ | 1 |
| Genti-Raimondi, S | 2 |
| Alvarez, CI | 1 |
| Patrito, LC | 1 |
| Flury, A | 2 |
| Blanco, JG | 1 |
| Gil, RR | 1 |
| Bocco, JL | 1 |
| Meragelman, TL | 1 |
| Tseng, L | 1 |
| Tseng, JK | 1 |
| Mann, WJ | 1 |
| Chumas, JC | 1 |
| Stone, ML | 1 |
| Mazella, J | 1 |
| Sun, B | 1 |
| Amalfitano, TG | 1 |
| Wallach, RC | 1 |
| Yamamoto, T | 1 |
| Takamori, K | 1 |
| Okada, H | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Multicentric, Randomized, Non Comparative, Open-label Phase I/II Evaluating AZD2014 (Dual Mammalian Target of Rapamycin Complex 1/2 (mTORC1/mTORC2) Inhibitor) in Combination With Anastrozole Versus Anastrozole Alone in the Treatment of Metastatic Hormon[NCT02730923] | Phase 1/Phase 2 | 72 participants (Anticipated) | Interventional | 2016-04-30 | Active, not recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for aminoglutethimide and Uterine Neoplasms
| Article | Year |
|---|---|
Progestin therapy of endometrial, breast and ovarian carcinoma. A review of clinical observations.
Topics: Aminoglutethimide; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Bromocriptine; | 1984 |
8 other studies available for aminoglutethimide and Uterine Neoplasms
| Article | Year |
|---|---|
[Current status of drug treatment of endometrial carcinoma].
Topics: Aminoglutethimide; Antineoplastic Agents; Estrogen Antagonists; Female; Humans; Immunotherapy; Medro | 1983 |
Aminoglutethimide and warfarin. A new important drug interaction.
Topics: Aged; Aminoglutethimide; Chromatography, High Pressure Liquid; Drug Interactions; Female; Humans; Ki | 1984 |
Tamoxifen and aminoglutethimide in the management of patients with advanced endometrial carcinoma not responsive to medroxyprogesterone.
Topics: Adenocarcinoma; Aged; Aminoglutethimide; Drug Resistance; Female; Follow-Up Studies; Humans; Medroxy | 1981 |
Low aromatase activity in microsomes from complete hydatidiform mole.
Topics: Abortion, Therapeutic; Aminoglutethimide; Aromatase; Female; Humans; Hydatidiform Mole; Kinetics; Mi | 1993 |
Aromatase inhibition by an 11,13-dihydroderivative of a sesquiterpene lactone.
Topics: Aminoglutethimide; Androstenedione; Animals; Antineoplastic Agents; Aromatase; Aromatase Inhibitors; | 2001 |
Endocrine aspects of human uterine sarcoma: a preliminary study.
Topics: Adult; Aged; Aminoglutethimide; Animals; Aromatase; Aromatase Inhibitors; Cells, Cultured; Estradiol | 1986 |
Endocrine aspects of human uterine sarcoma.
Topics: Aminoglutethimide; Antineoplastic Agents; Estrogens; Female; Humans; Sarcoma; Uterine Neoplasms | 1988 |
Effect of aminoglutethimide on androstenedione aromatase activity in human uterine leiomyoma.
Topics: Aminoglutethimide; Aromatase Inhibitors; Estradiol; Estrone; Female; Humans; In Vitro Techniques; Le | 1985 |