aminoglutethimide has been researched along with Sensitivity and Specificity in 4 studies
Aminoglutethimide: An aromatase inhibitor that is used in the treatment of advanced BREAST CANCER.
aminoglutethimide : A dicarboximide that is a six-membered cyclic compound having ethyl and 4-aminophenyl substituents at the 3-position.
Sensitivity and Specificity: Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)
| Excerpt | Relevance | Reference |
|---|---|---|
| "A major obstacle to the understanding of the mechanisms of action of aromatase inhibitors in breast cancer is the observation that plasma estrogens are sustained at about 30-50% of their control levels despite 85-95% inhibition of the conversion of tracer androstenedione (A) to estrone (E1)." | 3.69 | A sensitive assay for measurement of plasma estrone sulphate in patients on treatment with aromatase inhibitors. ( Ekse, D; Lønning, PE, 1995) |
| " The bioassay was applied for a dose-response study of mono(2-ethylhexyl)phthalate (MEHP), a chemical known to disrupt several steroidogenic enzymes." | 1.35 | Steroidogenesis-disrupting compounds can be effectively studied for major fertility-related endpoints using in vitro cultured mouse follicles. ( Lenie, S; Smitz, J, 2009) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (25.00) | 18.2507 |
| 2000's | 3 (75.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Lézé, MP | 1 |
| Le Borgne, M | 1 |
| Pinson, P | 1 |
| Palusczak, A | 1 |
| Duflos, M | 1 |
| Le Baut, G | 1 |
| Hartmann, RW | 1 |
| Lenie, S | 1 |
| Smitz, J | 1 |
| Hefnawy, MM | 1 |
| Lønning, PE | 1 |
| Ekse, D | 1 |
4 other studies available for aminoglutethimide and Sensitivity and Specificity
| Article | Year |
|---|---|
Synthesis and biological evaluation of 5-[(aryl)(1H-imidazol-1-yl)methyl]-1H-indoles: potent and selective aromatase inhibitors.
Topics: Aromatase Inhibitors; Imidazoles; Indoles; Inhibitory Concentration 50; Methylation; Molecular Struc | 2006 |
Steroidogenesis-disrupting compounds can be effectively studied for major fertility-related endpoints using in vitro cultured mouse follicles.
Topics: Aminoglutethimide; Animals; Animals, Newborn; Diethylhexyl Phthalate; Dose-Response Relationship, Dr | 2009 |
Stereoselective determination of pyridoglutethimide enantiomers in serum with a chiral cellulose-based high-performance liquid chromatographic column using solid phase extraction and UV detection.
Topics: Aminoglutethimide; Animals; Calibration; Cattle; Cellulose; Chromatography, High Pressure Liquid; Re | 2003 |
A sensitive assay for measurement of plasma estrone sulphate in patients on treatment with aromatase inhibitors.
Topics: Aminoglutethimide; Androstenedione; Antineoplastic Combined Chemotherapy Protocols; Aromatase Inhibi | 1995 |