aminoglutethimide has been researched along with Hypertension in 14 studies
Aminoglutethimide: An aromatase inhibitor that is used in the treatment of advanced BREAST CANCER.
aminoglutethimide : A dicarboximide that is a six-membered cyclic compound having ethyl and 4-aminophenyl substituents at the 3-position.
Hypertension: Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is currently defined as when SYSTOLIC PRESSURE is consistently greater than 140 mm Hg or when DIASTOLIC PRESSURE is consistently 90 mm Hg or more.
| Excerpt | Relevance | Reference |
|---|---|---|
| "An inhibitor of adrenal steroid biosynthesis, aminoglutethimide, was administered to seven patients with low renin essential hypertension, and the antihypertensive action of the drug was compared with its effects on adrenal steroid production." | 7.66 | Effect of aminoglutethimide on blood pressure and steroid secretion in patients with low renin essential hypertension. ( Bartter, FC; Franklin, RB; Gill, JR; McMurtry, RJ; Mitchell, JR; Snodgrass, WR; Taylor, AA, 1978) |
| " Blood pressure was normal during treatment with spironolactone and during pregnancy, when the action of aldosterone and other similar steroids was presumably blocked by an increased production of progesterone; this suggests that the hypertension is dependent upon sodium-retaining steroids such as aldosterone." | 3.66 | Overproduction of sodium-retaining steroids by the zona glomerulosa is adrenocorticotropin-dependent and mediates hypertension in dexamethasone-suppressible aldosteronism. ( Bartter, FC; Gill, JR, 1981) |
| "An inhibitor of adrenal steroid biosynthesis, aminoglutethimide, was administered to seven patients with low renin essential hypertension, and the antihypertensive action of the drug was compared with its effects on adrenal steroid production." | 3.66 | Effect of aminoglutethimide on blood pressure and steroid secretion in patients with low renin essential hypertension. ( Bartter, FC; Franklin, RB; Gill, JR; McMurtry, RJ; Mitchell, JR; Snodgrass, WR; Taylor, AA, 1978) |
| "The blood pressure elevation of primary aldosteronism is caused by excessive production of the known mineralocorticoid, aldosterone." | 2.64 | Are there unknown mineralocorticoids in low-renin essential hypertension? ( Hollifield, JW; Island, DP; Liddle, GW; Sennett, JA; Slaton, PE; Wilson, HM; Yarbro, L, 1977) |
| "Two case reports are described, both breast carcinoma patients with metastatic disease." | 1.27 | A call for caution in the use of aminoglutethimide: negative interactions with dexamethasone and beta blocker treatment. ( Baerwald, H; Catane, R; Halpern, J, 1984) |
| "The hypothesis that hyperaldosteronism is not the sole cause of hypertension in dexamethasone-suppressible hyperaldosteronsim was tested in an 18-year-old male." | 1.26 | Evidence for an unidentified ACTH-induced steroid hormone causing hypertension. ( Levine, LS; New, MI; Peterson, RE; Saenger, P, 1976) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 13 (92.86) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (7.14) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Harinck, HI | 1 |
| van Brummelen, P | 1 |
| Van Seters, AP | 1 |
| Moolenaar, AJ | 1 |
| Halpern, J | 1 |
| Catane, R | 1 |
| Baerwald, H | 1 |
| Gill, JR | 2 |
| Bartter, FC | 2 |
| RodrÃguez, JA | 1 |
| Liddle, GW | 4 |
| Taylor, AA | 1 |
| Mitchell, JR | 1 |
| Snodgrass, WR | 1 |
| McMurtry, RJ | 1 |
| Franklin, RB | 1 |
| New, MI | 1 |
| Peterson, RE | 1 |
| Saenger, P | 1 |
| Levine, LS | 1 |
| Hollifield, JW | 1 |
| Slaton, PE | 1 |
| Wilson, HM | 1 |
| Sennett, JA | 1 |
| Yarbro, L | 1 |
| Island, DP | 1 |
| Temple, TE | 1 |
| Jacobelli, A | 1 |
| Borgia, MC | 1 |
| Borgia, C | 1 |
| Sellini, M | 1 |
| Aida, M | 1 |
| Miura, K | 1 |
| Mancheno-Rico, E | 1 |
| Kuchel, O | 1 |
| Nowaczynski, W | 1 |
| Seth, KK | 1 |
| Sasaki, C | 1 |
| Dawson, K | 1 |
| Genest, J | 1 |
| Chart, JJ | 1 |
| Gisoldi, E | 1 |
| Gaunt, R | 1 |
| Woods, JW | 1 |
| Michelakis, AM | 1 |
| Brill, AB | 1 |
2 reviews available for aminoglutethimide and Hypertension
| Article | Year |
|---|---|
Inhibitors of adrenal steroid biosynthesis.
Topics: Adrenal Cortex Hormones; Adrenal Glands; Adrenocorticotropic Hormone; Aldosterone; Aminoglutethimide | 1970 |
[Agents inhibiting steroid biosynthesis--aminoglutethimide and o,p'-DDD].
Topics: Adrenal Cortex; Adrenal Cortex Hormones; Adrenal Glands; Adrenocorticotropic Hormone; Adult; Aminogl | 1974 |
2 trials available for aminoglutethimide and Hypertension
| Article | Year |
|---|---|
Are there unknown mineralocorticoids in low-renin essential hypertension?
Topics: Aminoglutethimide; Blood Pressure; Clinical Trials as Topic; Humans; Hyperaldosteronism; Hypertensio | 1977 |
[Use of aminoglutethimide in the treatment of Cushing's syndrome].
Topics: 17-Hydroxycorticosteroids; Adrenocorticotropic Hormone; Aminoglutethimide; Clinical Trials as Topic; | 1974 |
10 other studies available for aminoglutethimide and Hypertension
| Article | Year |
|---|---|
Apparent mineralocorticoid excess and deficient 11 beta-oxidation of cortisol in a young female.
Topics: Adrenocorticotropic Hormone; Adult; Alkalosis; Amiloride; Aminoglutethimide; Dexamethasone; Drug The | 1984 |
A call for caution in the use of aminoglutethimide: negative interactions with dexamethasone and beta blocker treatment.
Topics: Adrenergic beta-Antagonists; Aged; Aminoglutethimide; Brain Neoplasms; Breast Neoplasms; Dexamethaso | 1984 |
Overproduction of sodium-retaining steroids by the zona glomerulosa is adrenocorticotropin-dependent and mediates hypertension in dexamethasone-suppressible aldosteronism.
Topics: Adrenal Cortex; Adrenocorticotropic Hormone; Adult; Aldosterone; Aminoglutethimide; Child, Preschool | 1981 |
[Syndrome of apparent mineralocorticoid excess caused by a deficiency of 11 beta-hydroxysteroid dehydrogenase: clinical and genetic study in a Chilean family followed for 19 years].
Topics: 11-beta-Hydroxysteroid Dehydrogenase Type 1; Adolescent; Aminoglutethimide; Blood Pressure; Body Hei | 2000 |
The Distinguished Lecture. Is hypertension essential?
Topics: Aldosterone; Aminoglutethimide; Angiotensin II; Animals; Dehydroepiandrosterone; Humans; Hypertensio | 1975 |
Effect of aminoglutethimide on blood pressure and steroid secretion in patients with low renin essential hypertension.
Topics: 18-Hydroxydesoxycorticosterone; Adrenal Cortex Hormones; Aminoglutethimide; Blood Pressure; Dehydroe | 1978 |
Evidence for an unidentified ACTH-induced steroid hormone causing hypertension.
Topics: 18-Hydroxydesoxycorticosterone; Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Adult; Aldoste | 1976 |
A dissociated effect of amino-glutethimide on the mineralocorticoid secretion in man.
Topics: Adult; Aldosterone; Aminoglutethimide; Carbon Isotopes; Corticosterone; Desoxycorticosterone; Dexame | 1973 |
Effect of aminoglutethimide in adrenal regeneration hypertension.
Topics: Adrenal Medulla; Adrenalectomy; Aminoglutethimide; Aniline Compounds; Animals; Anticonvulsants; Bloo | 1969 |
Effect of an adrenal inhibitor in hypertensive patients with suppressed renin.
Topics: Adult; Aminoglutethimide; Aniline Compounds; Anticonvulsants; Blood Pressure; Female; Humans; Hypert | 1969 |