aminoglutethimide has been researched along with Experimental Mammary Neoplasms in 26 studies
Aminoglutethimide: An aromatase inhibitor that is used in the treatment of advanced BREAST CANCER.
aminoglutethimide : A dicarboximide that is a six-membered cyclic compound having ethyl and 4-aminophenyl substituents at the 3-position.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Approximately one third of human breast carcinomas are hormone dependent and regress upon reduction of circulating estrogen levels." | 7.76 | Aromatase in breast cancer and the role of aminoglutethimide and other aromatase inhibitors. ( Brodie, AM; Santen, RJ, 1986) |
| "Approximately one third of human breast carcinomas are hormone dependent and regress upon reduction of circulating estrogen levels." | 3.76 | Aromatase in breast cancer and the role of aminoglutethimide and other aromatase inhibitors. ( Brodie, AM; Santen, RJ, 1986) |
| "Experimental combined hormone therapy with tamoxifen, aminoglutethimide and medroxyprogesterone acetate was investigated using three hormone-dependent human breast carcinomas serially transplanted into nude mice." | 3.67 | Experimental combined hormone therapy on human breast carcinomas serially transplanted into nude mice. ( Enomoto, K; Fukutomi, T; Ikeda, T; Ishibiki, K; Isobe, Y; Kikuyama, S; Kubota, T; Nakamura, A; Nishiumi, T; Shimada, A, 1986) |
| "One-third of the cases of breast cancer in postmenopausal women are hormone-dependent and the lesions regress upon treatment with antiestrogens or inhibition of estrogen biosynthesis." | 2.37 | Enzymatic control of estrogen production in human breast cancer: relative significance of aromatase versus sulfatase pathways. ( Feil, PD; Leszczynski, D; Manni, A; Santen, RJ; Santner, SJ; Tilson-Mallet, N; Wright, C, 1986) |
| "In order to mimic postmenopausal breast cancer, we ovariectomized rats after N-methyl-N-nitrosourea administration." | 1.27 | Response of nitrosomethylurea-induced rat mammary tumor to endocrine therapy and comparison with clinical response. ( Coombes, RC; Easton, D; Goss, PE; Singh, D; Wilkinson, JR; Williams, JC, 1986) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 15 (57.69) | 18.7374 |
| 1990's | 11 (42.31) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Bayer, H | 3 |
| Batzl, C | 3 |
| Hartmann, RW | 6 |
| Mannschreck, A | 1 |
| Stanek, J | 1 |
| Alder, A | 1 |
| Bellus, D | 1 |
| Bhatnagar, AS | 3 |
| Häusler, A | 2 |
| Schieweck, K | 3 |
| Grün, G | 3 |
| Sergejew, T | 1 |
| Bartz, U | 2 |
| Mitrenga, M | 1 |
| Oohata, N | 1 |
| Kawamura, I | 1 |
| Lacey, E | 1 |
| Nishigaki, F | 1 |
| Matsumoto, S | 1 |
| Tsujimoto, S | 1 |
| Naoe, Y | 1 |
| Manda, T | 1 |
| Shimomura, K | 1 |
| Lubet, RA | 1 |
| Steele, VE | 1 |
| Casebolt, TL | 1 |
| Eto, I | 1 |
| Kelloff, GJ | 1 |
| Grubbs, CJ | 1 |
| Tekmal, RR | 1 |
| Durgam, VR | 1 |
| McGuire, WL | 1 |
| Chamness, GC | 1 |
| Horwitz, KB | 1 |
| Zava, DT | 1 |
| Seifter, E | 1 |
| Critselis, AN | 1 |
| Levenson, SM | 1 |
| Rettura, G | 1 |
| Görlich, M | 1 |
| Winterfeld, G | 1 |
| Hauff, P | 1 |
| Arnold, W | 1 |
| Fichtner, I | 1 |
| Staab, HJ | 1 |
| Palzer, M | 1 |
| Rao, AR | 2 |
| Hussain, SP | 1 |
| Jannu, LN | 1 |
| Kumari, MV | 1 |
| de Launoit, Y | 1 |
| Kiss, R | 1 |
| Dauvois, S | 1 |
| Labrie, F | 1 |
| Fukutomi, T | 2 |
| Kubota, T | 1 |
| Ikeda, T | 1 |
| Isobe, Y | 1 |
| Kikuyama, S | 1 |
| Shimada, A | 1 |
| Nakamura, A | 1 |
| Nishiumi, T | 1 |
| Enomoto, K | 1 |
| Ishibiki, K | 1 |
| Matter, A | 1 |
| Brodie, AM | 3 |
| Santen, RJ | 2 |
| Leszczynski, D | 1 |
| Tilson-Mallet, N | 1 |
| Feil, PD | 1 |
| Wright, C | 1 |
| Manni, A | 1 |
| Santner, SJ | 1 |
| Wing, LY | 2 |
| Goss, P | 1 |
| Dowsett, M | 1 |
| Coombes, RC | 2 |
| Wilkinson, JR | 1 |
| Williams, JC | 1 |
| Singh, D | 1 |
| Goss, PE | 1 |
| Easton, D | 1 |
| Garrett, WM | 1 |
| Das, MG | 1 |
| Das, P | 1 |
4 reviews available for aminoglutethimide and Experimental Mammary Neoplasms
| Article | Year |
|---|---|
Prolactin and estrogen receptors in breast cancer.
Topics: Aminoglutethimide; Animals; Breast Neoplasms; Dexamethasone; Disease Models, Animal; Estrogen Antago | 1977 |
Inhibition of aromatase in vitro and in vivo by aromatase inhibitors.
Topics: Aminoglutethimide; Animals; Aromatase Inhibitors; Estrogen Antagonists; Female; Kinetics; Mammary Ne | 1990 |
Aromatase in breast cancer and the role of aminoglutethimide and other aromatase inhibitors.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Adult; Aged; Aminoglutethimide; Androgens; Androstenedione; Animal | 1986 |
Enzymatic control of estrogen production in human breast cancer: relative significance of aromatase versus sulfatase pathways.
Topics: 17-Hydroxysteroid Dehydrogenases; Adrenalectomy; Aminoglutethimide; Androstenedione; Animals; Aromat | 1986 |
1 trial available for aminoglutethimide and Experimental Mammary Neoplasms
| Article | Year |
|---|---|
Aromatase in breast cancer and the role of aminoglutethimide and other aromatase inhibitors.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Adult; Aged; Aminoglutethimide; Androgens; Androstenedione; Animal | 1986 |
22 other studies available for aminoglutethimide and Experimental Mammary Neoplasms
| Article | Year |
|---|---|
New aromatase inhibitors. Synthesis and biological activity of pyridyl-substituted tetralone derivatives.
Topics: Animals; Aromatase Inhibitors; Chromatography, High Pressure Liquid; Female; Humans; Lyases; Magneti | 1991 |
Synthesis and aromatase inhibitory activity of novel 1-(4-aminophenyl)-3-azabicyclo[3.1.0]hexane- and -[3.1.1]heptane-2,4- diones.
Topics: Aniline Compounds; Animals; Antineoplastic Agents; Aromatase Inhibitors; Bridged Bicyclo Compounds; | 1991 |
Aromatase inhibitors. Synthesis and evaluation of mammary tumor inhibiting activity of 3-alkylated 3-(4-aminophenyl)piperidine-2,6-diones.
Topics: Adrenal Glands; Alkylation; Animals; Aromatase Inhibitors; Cattle; Crystallization; Estrogens; Femal | 1986 |
Pyridyl-substituted tetrahydrocyclopropa[a]naphthalenes: highly active and selective inhibitors of P450 arom.
Topics: Adrenal Glands; Animals; Antineoplastic Agents; Aromatase Inhibitors; Cattle; Female; Humans; Liver; | 1995 |
Aromatase inhibitors. Syntheses and structure-activity studies of novel pyridyl-substituted indanones, indans, and tetralins.
Topics: Androstenedione; Animals; Antineoplastic Agents; Aromatase; Aromatase Inhibitors; Cattle; Female; Hu | 1994 |
A new aromatase inhibitor, FR901537. II. Pharmacological and antitumor effects.
Topics: Aminoglutethimide; Animals; Antibiotics, Antineoplastic; Aromatase Inhibitors; Bacillus; Body Weight | 1995 |
Chemopreventive effects of the aromatase inhibitors vorozole (R-83842) and 4-hydroxyandrostenedione in the methylnitrosourea (MNU)-induced mammary tumor model in Sprague-Dawley rats.
Topics: Adenocarcinoma; Aminoglutethimide; Androstenedione; Animals; Anticarcinogenic Agents; Aromatase Inhi | 1994 |
A novel in vitro and in vivo breast cancer model for testing inhibitors of estrogen biosynthesis and its action using mammary tumor cells with an activated int-5/aromatase gene.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Aminoglutethimide; Analysis of Variance; Anastrozole; Androstenedi | 1997 |
Effect of metyrapone and aminoglutethimide on the murine sarcoma (MuSV-M) and breast adenocarcinoma (C3HBA).
Topics: Adenocarcinoma; Aminoglutethimide; Animals; Female; Male; Mammary Neoplasms, Experimental; Metyrapon | 1979 |
Investigations of droloxifene and other hormonal manipulations on N-nitrosomethylurea-induced rat mammary tumours. 2. Influence on oestrogen receptor.
Topics: Aminoglutethimide; Animals; Antineoplastic Agents; Estradiol; Estrogen Antagonists; Female; Mammary | 1992 |
Evaluation of the racemate and the enantiomers of a new highly active and selective aromatase inhibitor of the aminoglutethimide type.
Topics: Adrenal Glands; Aldosterone; Aminoglutethimide; Animals; Aromatase Inhibitors; Cattle; Corticosteron | 1992 |
Modulatory influences of tamoxifen, tocopherol, retinyl acetate, aminoglutethimide, ergocryptine and selenium on DMBA-induced initiation of mammary carcinogenesis in rats.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Aminoglutethimide; Animals; Diterpenes; Drug Interactions; Ergolin | 1990 |
In vivo influence of androgens on the cell kinetics and chromatin pattern of the MXT mouse mammary tumor treated or not by aminoglutethimide.
Topics: Aminoglutethimide; Androgens; Animals; Aromatase Inhibitors; Cell Cycle; Cell Line; Chromatin; Color | 1989 |
Androstenedione and androst-5-ene-3 beta,17 beta-diol stimulate DMBA-induced rat mammary tumors--role of aromatase.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Aminoglutethimide; Androstenediol; Androstenediols; Androstenedion | 1989 |
[Experimental multihormone therapy on human breast carcinomas grown in nude mice].
Topics: Aminoglutethimide; Animals; Drug Therapy, Combination; Estrogens; Female; Mammary Neoplasms, Experim | 1989 |
Experimental combined hormone therapy on human breast carcinomas serially transplanted into nude mice.
Topics: Adult; Aminoglutethimide; Animals; Antineoplastic Combined Chemotherapy Protocols; Carcinoma; Estrad | 1986 |
CGS 16949A, a new nonsteroidal aromatase inhibitor: effects on hormone-dependent and -independent tumors in vivo.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Aminoglutethimide; Animals; Aromatase Inhibitors; Body Weight; Cel | 1988 |
[Inhibitors of aromatase. Synthesis and pharmacologic action of potential mammary tumor-inhibiting 4-alkyl-3-(4-aminophenyl)-3-ethylpiperidine-2,6-diones].
Topics: Aminoglutethimide; Animals; Antineoplastic Agents; Aromatase Inhibitors; Estradiol; Female; Lyases; | 1987 |
Aromatase inhibitors and the treatment of breast cancer.
Topics: Adult; Aged; Aminoglutethimide; Androstenedione; Animals; Aromatase Inhibitors; Breast Neoplasms; Es | 1986 |
Response of nitrosomethylurea-induced rat mammary tumor to endocrine therapy and comparison with clinical response.
Topics: Aminoglutethimide; Androstenedione; Animals; Antineoplastic Combined Chemotherapy Protocols; Breast | 1986 |
Effects of aromatase inhibitors, aminoglutethimide, and 4-hydroxyandrostenedione on cyclic rats and rats with 7,12-dimethylbenz(a)anthracene-induced mammary tumors.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Aminoglutethimide; Androstenedione; Animals; Aromatase Inhibitors; | 1985 |
Inhibitory action of aminoglutethimide on DMBA-induced mammary carcinogenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Aminoglutethimide; Animals; Diet; Female; Mammary Neoplasms, Exper | 1985 |