aminoglutethimide has been researched along with Carcinoma, Anaplastic in 18 studies
Aminoglutethimide: An aromatase inhibitor that is used in the treatment of advanced BREAST CANCER.
aminoglutethimide : A dicarboximide that is a six-membered cyclic compound having ethyl and 4-aminophenyl substituents at the 3-position.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Inhibition of estrogen action at the target tissue level with the antiestrogen, tamoxifen, has proved highly successful in the treatment of hormone-responsive breast cancer." | 10.16 | Tamoxifen therapy of metastatic breast cancer. ( Manni, A, 1987) |
| "Inhibition of estrogen action at the target tissue level with the antiestrogen, tamoxifen, has proved highly successful in the treatment of hormone-responsive breast cancer." | 6.16 | Tamoxifen therapy of metastatic breast cancer. ( Manni, A, 1987) |
| "Hormonal therapy of breast cancer is the oldest treatment in advanced disease." | 5.29 | Megestrol acetate in advanced breast carcinoma. ( Espie, M, 1994) |
| "Three sequential phase II trials were performed in patients with refractory epithelial ovarian carcinoma, using high-dose megestrol acetate (800 mg/d for 30 days, then 400 mg/d), high-dose tamoxifen (80 mg/d for 30 days, then 40 mg/d), and aminoglutethimide (1 g/d plus tapering doses of hydrocortisone)." | 5.07 | Hormonal palliation of chemoresistant ovarian cancer: three consecutive phase II trials of the Mid-Atlantic Oncology Program. ( Ahlgren, JD; Alt, D; Ellison, NM; Gottlieb, RJ; Laluna, F; Lokich, JJ; Sinclair, PR; Ueno, W; Wampler, GL; Yeung, KY, 1993) |
| " by metyrapone test or by congenital adrenal hyperplasia resulting from 11 beta-hydroxylase deficiency." | 3.69 | An alternate pathway to androstenedione synthesis by human adrenals: evidence of a balance in 11 beta-hydroxylase and 17,20-lyase activities leading to androstenedione. ( Auzéby, A; Bogdan, A; Touitou, Y, 1995) |
| "Experimental combined hormone therapy with tamoxifen, aminoglutethimide and medroxyprogesterone acetate was investigated using three hormone-dependent human breast carcinomas serially transplanted into nude mice." | 3.67 | Experimental combined hormone therapy on human breast carcinomas serially transplanted into nude mice. ( Enomoto, K; Fukutomi, T; Ikeda, T; Ishibiki, K; Isobe, Y; Kikuyama, S; Kubota, T; Nakamura, A; Nishiumi, T; Shimada, A, 1986) |
| "Aminoglutethimide was examined only for effects on CYP11A activity and was shown to inhibit pregnenolone formation (20 microM: 61 +/- 4% of control)." | 1.31 | Effects of 3-MeSO2-DDE and some CYP inhibitors on glucocorticoid steroidogenesis in the H295R human adrenocortical carcinoma cell line. ( Johansson, MK; Lund, BO; Sanderson, JT, 2002) |
| "Hormonal therapy of breast cancer is the oldest treatment in advanced disease." | 1.29 | Megestrol acetate in advanced breast carcinoma. ( Espie, M, 1994) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 13 (72.22) | 18.7374 |
| 1990's | 4 (22.22) | 18.2507 |
| 2000's | 1 (5.56) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Carlström, K | 1 |
| Döberl, A | 1 |
| Pousette, A | 1 |
| Rannevik, G | 1 |
| Wilking, N | 1 |
| Ivković, T | 1 |
| Kissin, MW | 1 |
| Kark, AE | 1 |
| Ahlgren, JD | 1 |
| Ellison, NM | 1 |
| Gottlieb, RJ | 1 |
| Laluna, F | 1 |
| Lokich, JJ | 1 |
| Sinclair, PR | 1 |
| Ueno, W | 1 |
| Wampler, GL | 1 |
| Yeung, KY | 1 |
| Alt, D | 1 |
| Freeman, DA | 1 |
| Auzéby, A | 1 |
| Bogdan, A | 1 |
| Touitou, Y | 1 |
| Espie, M | 1 |
| Johansson, MK | 1 |
| Sanderson, JT | 1 |
| Lund, BO | 1 |
| Pinerua, RF | 1 |
| Dunn, CM | 1 |
| McElduff, A | 1 |
| Clifton-Bligh, P | 1 |
| Posen, S | 1 |
| Chang, AY | 1 |
| Bennett, JM | 1 |
| Pandya, KJ | 1 |
| Asbury, R | 1 |
| McCune, C | 1 |
| Vachalovský, V | 2 |
| Vomácka, V | 2 |
| Fukutomi, T | 1 |
| Kubota, T | 1 |
| Ikeda, T | 1 |
| Isobe, Y | 1 |
| Kikuyama, S | 1 |
| Shimada, A | 1 |
| Nakamura, A | 1 |
| Nishiumi, T | 1 |
| Enomoto, K | 1 |
| Ishibiki, K | 1 |
| Manni, A | 1 |
| Santen, RJ | 1 |
| Boucher, AE | 1 |
| Santner, SJ | 1 |
| Henderson, IC | 1 |
| Harvey, H | 1 |
| Lipton, A | 1 |
| Smilo, RP | 1 |
| Earll, JM | 1 |
| Forsham, PH | 1 |
| Orth, DN | 1 |
| Liddle, GW | 1 |
1 review available for aminoglutethimide and Carcinoma, Anaplastic
| Article | Year |
|---|---|
Tamoxifen therapy of metastatic breast cancer.
Topics: Aminoglutethimide; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Carcinoma; Clin | 1987 |
4 trials available for aminoglutethimide and Carcinoma, Anaplastic
| Article | Year |
|---|---|
Hormonal palliation of chemoresistant ovarian cancer: three consecutive phase II trials of the Mid-Atlantic Oncology Program.
Topics: Adenocarcinoma; Aminoglutethimide; Carcinoma; Drug Resistance; Drug Therapy, Combination; Female; Hu | 1993 |
[Orimeten in the treatment of advanced carcinoma of the prostate].
Topics: Aged; Aged, 80 and over; Aminoglutethimide; Antineoplastic Agents; Carcinoma; Cyclophosphamide; Drug | 1989 |
Tamoxifen therapy of metastatic breast cancer.
Topics: Aminoglutethimide; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Carcinoma; Clin | 1987 |
Inhibition of aromatase as treatment of breast carcinoma in postmenopausal women.
Topics: Aminoglutethimide; Aromatase Inhibitors; Breast Neoplasms; Carcinoma; Clinical Trials as Topic; Dose | 1987 |
14 other studies available for aminoglutethimide and Carcinoma, Anaplastic
| Article | Year |
|---|---|
Inhibition of steroid sulfatase activity by danazol.
Topics: Aminoglutethimide; Breast Neoplasms; Carcinoma; Culture Techniques; Danazol; Dehydroepiandrosterone; | 1984 |
[Use of aminoglutethimide in a patient with carcinoma of the adrenal cortex].
Topics: Adrenal Cortex Neoplasms; Aminoglutethimide; Carcinoma; Female; Humans; Middle Aged | 1983 |
Irreversible thrombocytopenia following aminoglutethimide.
Topics: Aminoglutethimide; Bone Marrow; Breast Neoplasms; Carcinoma; Female; Humans; Middle Aged; Thrombocyt | 1983 |
Adrenal carcinoma.
Topics: Adenoma; Adrenal Gland Neoplasms; Adrenalectomy; Aminoglutethimide; Carcinoma; Cushing Syndrome; Dia | 1994 |
An alternate pathway to androstenedione synthesis by human adrenals: evidence of a balance in 11 beta-hydroxylase and 17,20-lyase activities leading to androstenedione.
Topics: Adenoma; Adolescent; Adrenal Gland Neoplasms; Adrenal Glands; Adrenal Hyperplasia, Congenital; Adult | 1995 |
Megestrol acetate in advanced breast carcinoma.
Topics: Aminoglutethimide; Breast Neoplasms; Carcinoma; Clinical Trials as Topic; Cross-Over Studies; Female | 1994 |
Effects of 3-MeSO2-DDE and some CYP inhibitors on glucocorticoid steroidogenesis in the H295R human adrenocortical carcinoma cell line.
Topics: Adrenal Cortex Neoplasms; Aminoglutethimide; Carcinoma; Chromatography, High Pressure Liquid; Colfor | 2002 |
Ectopic adrenocorticotrophic hormone production and neoplasm.
Topics: Adrenocorticotropic Hormone; Adult; Aminoglutethimide; Bronchial Neoplasms; Carbon Dioxide; Carcinom | 1975 |
Metastatic medullary carcinoma of the thyroid complicated by Cushing's syndrome.
Topics: Adult; Aminoglutethimide; Carcinoma; Cushing Syndrome; Dexamethasone; Drug Therapy, Combination; Hum | 1979 |
A study of aminoglutethemide and hydrocortisone in patients with advanced and refractory prostate carcinoma.
Topics: Aminoglutethimide; Carcinoma; Drug Evaluation; Drug Therapy, Combination; Humans; Hydrocortisone; Ma | 1989 |
Experimental combined hormone therapy on human breast carcinomas serially transplanted into nude mice.
Topics: Adult; Aminoglutethimide; Animals; Antineoplastic Combined Chemotherapy Protocols; Carcinoma; Estrad | 1986 |
[Orimeten in the treatment of advanced prostatic carcinoma].
Topics: Aged; Aged, 80 and over; Aminoglutethimide; Antineoplastic Combined Chemotherapy Protocols; Carcinom | 1988 |
Suppression of tumorous adrenal hyperfunction by aminoglutethimide.
Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adenoma; Adrenal Gland Neoplasms; Adrenocortical Hyperfu | 1967 |
Results of treatment in 108 patients with Cushing's syndrome.
Topics: Adenoma; Adolescent; Adrenal Gland Neoplasms; Adrenalectomy; Adrenocorticotropic Hormone; Adult; Age | 1971 |