aminoglutethimide has been researched along with Adenocarcinoma in 27 studies
Aminoglutethimide: An aromatase inhibitor that is used in the treatment of advanced BREAST CANCER.
aminoglutethimide : A dicarboximide that is a six-membered cyclic compound having ethyl and 4-aminophenyl substituents at the 3-position.
Adenocarcinoma: A malignant epithelial tumor with a glandular organization.
| Excerpt | Relevance | Reference |
|---|---|---|
| "A randomized study comparing low-dose aminoglutethimide (AG) with and without hydrocortisone (HC) was performed to investigate whether corticosteroid replacement contributes to the therapeutic effects of the drug administered as a front-line endocrine therapy in postmenopausal advanced breast cancer." | 9.07 | Low-dose aminoglutethimide with and without hydrocortisone replacement as a first-line endocrine treatment in advanced breast cancer: a prospective randomized trial of the Italian Oncology Group for Clinical Research. ( Bacchi, M; Bisagni, G; Boni, C; Brugia, M; Carpi, A; Ceci, G; Cocconi, G; Di Costanzo, F; Franciosi, V; Gori, S, 1992) |
| "Its role in the biology of breast cancer is unclear." | 5.26 | Effects of aminoglutethimide on delta 5-androstenediol metabolism in postmenopausal women with breast cancer. ( Bird, CE; Clark, AF; Masters, V; Sterns, EE, 1982) |
| "Three sequential phase II trials were performed in patients with refractory epithelial ovarian carcinoma, using high-dose megestrol acetate (800 mg/d for 30 days, then 400 mg/d), high-dose tamoxifen (80 mg/d for 30 days, then 40 mg/d), and aminoglutethimide (1 g/d plus tapering doses of hydrocortisone)." | 5.07 | Hormonal palliation of chemoresistant ovarian cancer: three consecutive phase II trials of the Mid-Atlantic Oncology Program. ( Ahlgren, JD; Alt, D; Ellison, NM; Gottlieb, RJ; Laluna, F; Lokich, JJ; Sinclair, PR; Ueno, W; Wampler, GL; Yeung, KY, 1993) |
| "A randomized study comparing low-dose aminoglutethimide (AG) with and without hydrocortisone (HC) was performed to investigate whether corticosteroid replacement contributes to the therapeutic effects of the drug administered as a front-line endocrine therapy in postmenopausal advanced breast cancer." | 5.07 | Low-dose aminoglutethimide with and without hydrocortisone replacement as a first-line endocrine treatment in advanced breast cancer: a prospective randomized trial of the Italian Oncology Group for Clinical Research. ( Bacchi, M; Bisagni, G; Boni, C; Brugia, M; Carpi, A; Ceci, G; Cocconi, G; Di Costanzo, F; Franciosi, V; Gori, S, 1992) |
| "Forty patients with metastatic adenocarcinoma of the prostate were evaluated for response to treatment with aminoglutethimide plus cortisone acetate." | 3.67 | Response to aminoglutethimide and cortisone acetate in advanced prostatic cancer. ( Chilvers, CE; Dowsett, M; Easton, D; Jeffcoate, SL; Miller, J; Pocock, RD; Ponder, BA; Shearer, RJ, 1984) |
| "A patient with advanced breast cancer who died of septicemia associated with aminoglutethimide induced agranulocytosis, is reported." | 3.67 | Aminoglutethimide-induced bone marrow injury. Report of a case and review of the literature. ( Keller, AM; Newcomer, LN; Young, JA, 1984) |
| "AG also can be used to treat endometrial carcinoma." | 2.68 | Exploration for drug therapy in endometrial carcinoma. ( Cao, B; Zhang, X, 1996) |
| "Estrogen receptors of human endometrial cancer Ishikawa cells were found to be present in moderate amounts (160-200 fmol/mg protein), and to specifically bind moxestrol (R2858) with a very high affinity characterized by a Kd around 60 pM, when measured under equilibrium conditions." | 1.29 | Lack of estrogenic potential of progesterone- or 19-nor-progesterone-derived progestins as opposed to testosterone or 19-nor-testosterone derivatives on endometrial Ishikawa cells. ( Botella, J; Delansorne, R; Duc, I; Duranti, E; Paris, J; Viader, V, 1995) |
| " Adrenal failure due to glucocorticoid deficiency was also present and required an increased dosage of cortisone." | 1.28 | Aminoglutethimide-induced hyperkalaemia. ( Bentley, P; Davies, JP; Ghose, RR, 1989) |
| "Its role in the biology of breast cancer is unclear." | 1.26 | Effects of aminoglutethimide on delta 5-androstenediol metabolism in postmenopausal women with breast cancer. ( Bird, CE; Clark, AF; Masters, V; Sterns, EE, 1982) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 17 (62.96) | 18.7374 |
| 1990's | 9 (33.33) | 18.2507 |
| 2000's | 1 (3.70) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Hobdy, EM | 1 |
| Shafi, NQ | 1 |
| Kummar, S | 1 |
| Ponder, BA | 1 |
| Shearer, RJ | 1 |
| Pocock, RD | 1 |
| Miller, J | 1 |
| Easton, D | 1 |
| Chilvers, CE | 1 |
| Dowsett, M | 1 |
| Jeffcoate, SL | 1 |
| Bird, CE | 1 |
| Masters, V | 1 |
| Sterns, EE | 1 |
| Clark, AF | 1 |
| Soloway, MS | 1 |
| Young, JA | 1 |
| Newcomer, LN | 1 |
| Keller, AM | 1 |
| Drago, JR | 3 |
| Santen, RJ | 2 |
| Lipton, A | 3 |
| Worgul, TJ | 2 |
| Harvey, HA | 2 |
| Boucher, A | 1 |
| Manni, A | 1 |
| Rohner, TJ | 3 |
| Samojlik, E | 1 |
| Veldhuis, JD | 1 |
| Quinn, MA | 1 |
| Campbell, JJ | 1 |
| Murray, R | 1 |
| Pepperell, RJ | 1 |
| Greenway, B | 1 |
| Duke, D | 1 |
| Pym, B | 1 |
| Iqbal, MJ | 1 |
| Johnson, PJ | 1 |
| Williams, R | 1 |
| Shessel, FS | 1 |
| Block, NL | 1 |
| Stover, B | 1 |
| Claflin, A | 1 |
| Malinin, TI | 1 |
| Politano, VA | 1 |
| Botella, J | 1 |
| Duranti, E | 1 |
| Viader, V | 1 |
| Duc, I | 1 |
| Delansorne, R | 1 |
| Paris, J | 1 |
| Ahlgren, JD | 1 |
| Ellison, NM | 1 |
| Gottlieb, RJ | 1 |
| Laluna, F | 1 |
| Lokich, JJ | 1 |
| Sinclair, PR | 1 |
| Ueno, W | 1 |
| Wampler, GL | 1 |
| Yeung, KY | 1 |
| Alt, D | 1 |
| Lubet, RA | 1 |
| Steele, VE | 1 |
| Casebolt, TL | 1 |
| Eto, I | 1 |
| Kelloff, GJ | 1 |
| Grubbs, CJ | 1 |
| Zhang, X | 1 |
| Cao, B | 1 |
| Bare, RL | 1 |
| Torti, FM | 1 |
| Bell, SC | 1 |
| Anderson, EG | 1 |
| Eggenberger, C | 1 |
| Brändle, M | 1 |
| Galeazzi, RL | 1 |
| Spinas, GA | 1 |
| Schmid, C | 1 |
| Seifter, E | 1 |
| Critselis, AN | 1 |
| Levenson, SM | 1 |
| Rettura, G | 1 |
| Sanford, EJ | 1 |
| Santen, R | 1 |
| Cocconi, G | 1 |
| Bisagni, G | 1 |
| Ceci, G | 1 |
| Bacchi, M | 1 |
| Boni, C | 1 |
| Brugia, M | 1 |
| Carpi, A | 1 |
| Di Costanzo, F | 1 |
| Franciosi, V | 1 |
| Gori, S | 1 |
| Adshead, F | 1 |
| De Graeff, A | 1 |
| Mansi, JL | 1 |
| Thomas, DM | 1 |
| Smith, IE | 1 |
| Davies, JP | 1 |
| Bentley, P | 1 |
| Ghose, RR | 1 |
| Fabre, JF | 1 |
| Pourreau-Schneider, N | 1 |
| Martin, PM | 1 |
| Puissant, A | 1 |
| Tel, W | 1 |
| van Lijf, JH | 1 |
| ten Napel, CH | 1 |
| Lönning, PE | 1 |
| Wiedemann, G | 1 |
| Kvinnsland, S | 1 |
| Lundgren, S | 1 |
| Crawford, ED | 1 |
| Ahmann, FR | 1 |
| Davis, MA | 1 |
| Levasseur, YJ | 1 |
| van der Heijden, JT | 1 |
| Splinter, TA | 1 |
2 reviews available for aminoglutethimide and Adenocarcinoma
| Article | Year |
|---|---|
Endocrine therapy of prostate cancer.
Topics: 5-alpha Reductase Inhibitors; Adenocarcinoma; Aminoglutethimide; Androgen Antagonists; Antineoplasti | 1998 |
Aminoglutethimide medical adrenalectomy for advanced prostatic carcinoma.
Topics: Adenocarcinoma; Adrenal Glands; Aged; Aminoglutethimide; Female; Humans; Male; Prostatic Neoplasms | 1976 |
3 trials available for aminoglutethimide and Adenocarcinoma
| Article | Year |
|---|---|
Hormonal palliation of chemoresistant ovarian cancer: three consecutive phase II trials of the Mid-Atlantic Oncology Program.
Topics: Adenocarcinoma; Aminoglutethimide; Carcinoma; Drug Resistance; Drug Therapy, Combination; Female; Hu | 1993 |
Exploration for drug therapy in endometrial carcinoma.
Topics: 17 alpha-Hydroxyprogesterone Caproate; Adenocarcinoma; Aged; Aged, 80 and over; Aminoglutethimide; A | 1996 |
Low-dose aminoglutethimide with and without hydrocortisone replacement as a first-line endocrine treatment in advanced breast cancer: a prospective randomized trial of the Italian Oncology Group for Clinical Research.
Topics: Adenocarcinoma; Adult; Aged; Aged, 80 and over; Aminoglutethimide; Breast Neoplasms; Drug Therapy, C | 1992 |
22 other studies available for aminoglutethimide and Adenocarcinoma
| Article | Year |
|---|---|
Prostate cancer metastasis to supraclavicular lymph node.
Topics: Acid Phosphatase; Adenocarcinoma; Aged; Aminoglutethimide; Antineoplastic Combined Chemotherapy Prot | 2004 |
Response to aminoglutethimide and cortisone acetate in advanced prostatic cancer.
Topics: Adenocarcinoma; Aged; Aminoglutethimide; Androstenedione; Antineoplastic Combined Chemotherapy Proto | 1984 |
Effects of aminoglutethimide on delta 5-androstenediol metabolism in postmenopausal women with breast cancer.
Topics: Adenocarcinoma; Adult; Aminoglutethimide; Androstenediol; Androstenediols; Breast Neoplasms; Carcino | 1982 |
Newer methods of hormonal therapy for prostate cancer.
Topics: Adenocarcinoma; Aminoglutethimide; Androgen Antagonists; Bone Neoplasms; Buserelin; Flutamide; Gonad | 1984 |
Aminoglutethimide-induced bone marrow injury. Report of a case and review of the literature.
Topics: Adenocarcinoma; Aminoglutethimide; Bone Marrow; Breast Neoplasms; Female; Humans; Middle Aged; Sepsi | 1984 |
Clinical effect of aminoglutethimide, medical adrenalectomy, in treatment of 43 patients with advanced prostatic carcinoma.
Topics: Adenocarcinoma; Adrenalectomy; Aged; Aminoglutethimide; Antineoplastic Combined Chemotherapy Protoco | 1984 |
Clinical and biochemical effect of aminoglutethimide in the treatment of advanced prostatic carcinoma.
Topics: Adenocarcinoma; Aged; Aminoglutethimide; Bone Neoplasms; Dihydrotestosterone; Drug Therapy, Combinat | 1983 |
Tamoxifen and aminoglutethimide in the management of patients with advanced endometrial carcinoma not responsive to medroxyprogesterone.
Topics: Adenocarcinoma; Aged; Aminoglutethimide; Drug Resistance; Female; Follow-Up Studies; Humans; Medroxy | 1981 |
The control of human pancreatic adenocarcinoma xenografts in nude mice by hormone therapy.
Topics: Adenocarcinoma; Aminoglutethimide; Animals; Cyproterone; Hormones; Humans; Hydrocortisone; Male; Mic | 1982 |
Endocrine manipulation of the Dunning prostatic adenocarcinoma.
Topics: Adenocarcinoma; Adrenalectomy; Aminoglutethimide; Animals; Castration; Diethylstilbestrol; Disease M | 1980 |
Lack of estrogenic potential of progesterone- or 19-nor-progesterone-derived progestins as opposed to testosterone or 19-nor-testosterone derivatives on endometrial Ishikawa cells.
Topics: Adenocarcinoma; Alkaline Phosphatase; Aminoglutethimide; Aromatase Inhibitors; Binding, Competitive; | 1995 |
Chemopreventive effects of the aromatase inhibitors vorozole (R-83842) and 4-hydroxyandrostenedione in the methylnitrosourea (MNU)-induced mammary tumor model in Sprague-Dawley rats.
Topics: Adenocarcinoma; Aminoglutethimide; Androstenedione; Animals; Anticarcinogenic Agents; Aromatase Inhi | 1994 |
Pulmonary eosinophilia associated with aminoglutethimide.
Topics: Adenocarcinoma; Aged; Aminoglutethimide; Antineoplastic Agents, Hormonal; Breast Neoplasms; Female; | 1998 |
[Cushing syndrome due to ectopic ACTH secretion: an uncommon case presentation, diagnosis and therapy].
Topics: ACTH Syndrome, Ectopic; Adenocarcinoma; Aminoglutethimide; Antineoplastic Agents, Hormonal; Diagnost | 1999 |
Effect of metyrapone and aminoglutethimide on the murine sarcoma (MuSV-M) and breast adenocarcinoma (C3HBA).
Topics: Adenocarcinoma; Aminoglutethimide; Animals; Female; Male; Mammary Neoplasms, Experimental; Metyrapon | 1979 |
Small cell carcinoma of the prostate: implications for management.
Topics: Adenocarcinoma; Aminoglutethimide; Bone Neoplasms; Carcinoma, Small Cell; Cyclophosphamide; Doxorubi | 1991 |
Aminoglutethimide-induced hyperkalaemia.
Topics: Adenocarcinoma; Aminoglutethimide; Breast Neoplasms; Female; Humans; Hyperkalemia; Middle Aged; Time | 1989 |
[Dosage and modulation of cutaneous steroid receptors during antihormonal therapy in a case of Stewart-Treves syndrome].
Topics: Adenocarcinoma; Aged; Aminoglutethimide; Breast Neoplasms; Female; Humans; Immunoenzyme Techniques; | 1988 |
[Transient bone marrow inhibition caused by aminoglutethimide].
Topics: Adenocarcinoma; Aminoglutethimide; Bone Marrow Diseases; Bone Neoplasms; Breast Neoplasms; Female; H | 1989 |
[Which hormone therapy should be used in advanced breast carcinoma in males?].
Topics: Adenocarcinoma; Aged; Aminoglutethimide; Axilla; Breast Neoplasms; Dexamethasone; Drug Evaluation; H | 1988 |
Aminoglutethimide in metastatic adenocarcinoma of the prostate.
Topics: Adenocarcinoma; Adult; Aged; Aged, 80 and over; Aminoglutethimide; Humans; Hydrocortisone; Male; Mid | 1987 |
Aminoglutethimide-induced myelosuppression.
Topics: Adenocarcinoma; Aged; Agranulocytosis; Aminoglutethimide; Breast Neoplasms; Female; Humans | 1986 |