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aminocaproic acid and Thrombopenia

aminocaproic acid has been researched along with Thrombopenia in 30 studies

Aminocaproic Acid: An antifibrinolytic agent that acts by inhibiting plasminogen activators which have fibrinolytic properties.
6-aminohexanoic acid : An epsilon-amino acid comprising hexanoic acid carrying an amino substituent at position C-6. Used to control postoperative bleeding, and to treat overdose effects of the thrombolytic agents streptokinase and tissue plasminogen activator.

Research Excerpts

ExcerptRelevanceReference
"To determine the efficacy and safety of antifibrinolytics (lysine analogues) in preventing bleeding in people with haematological disorders."8.93Antifibrinolytics (lysine analogues) for the prevention of bleeding in people with haematological disorders. ( Brunskill, SJ; Desborough, M; Doree, C; Estcourt, LJ; Hopewell, S; Murphy, MF; Stanworth, SJ, 2016)
"To determine the efficacy and safety of antifibrinolytics (lysine analogues) in preventing bleeding in patients with haematological disorders."8.89Antifibrinolytics (lysine analogues) for the prevention of bleeding in patients with haematological disorders. ( Brunskill, SJ; Doree, C; Estcourt, LJ; Murphy, MF; Stanworth, S; Trivella, M; Wardrop, D, 2013)
"Aminocaproic acid is frequently used in patients with hematologic malignancy that present with thrombocytopenia with or without hemorrhage."7.88Thromboembolic complications following aminocaproic acid use in patients with hematologic malignancies. ( Elefritz, JL; Juhl, RC; Li, J; Roddy, JVF; Wang, TF, 2018)
"Epsilon aminocaproic acid (EACA) is an antifibrinolytic drug that has been used to control hemorrhage by stabilizing the thrombus."7.73Epsilon aminocaproic acid reduces transfusion requirements in patients with thrombocytopenic hemorrhage. ( Jin, T; Kalaycio, M; Kalmadi, S; Lowe, C; Tiu, R, 2006)
"To report a case of rhabdomyolysis associated with epsilon-aminocaproic acid (epsilon-ACA)."7.69Rhabdomyolysis induced by epsilon-aminocaproic acid. ( Rubinger, M; Seymour, BD, 1997)
"To determine the efficacy and safety of antifibrinolytics (lysine analogues) in preventing bleeding in people with haematological disorders."4.93Antifibrinolytics (lysine analogues) for the prevention of bleeding in people with haematological disorders. ( Brunskill, SJ; Desborough, M; Doree, C; Estcourt, LJ; Hopewell, S; Murphy, MF; Stanworth, SJ, 2016)
"To determine the efficacy and safety of antifibrinolytics (lysine analogues) in preventing bleeding in patients with haematological disorders."4.89Antifibrinolytics (lysine analogues) for the prevention of bleeding in patients with haematological disorders. ( Brunskill, SJ; Doree, C; Estcourt, LJ; Murphy, MF; Stanworth, S; Trivella, M; Wardrop, D, 2013)
"Aminocaproic acid is frequently used in patients with hematologic malignancy that present with thrombocytopenia with or without hemorrhage."3.88Thromboembolic complications following aminocaproic acid use in patients with hematologic malignancies. ( Elefritz, JL; Juhl, RC; Li, J; Roddy, JVF; Wang, TF, 2018)
"The antifibrinolytic aminocaproic acid is widely used in surgical settings to prevent blood loss and decrease transfusion requirements, and small observational studies have suggested that aminocaproic acid may be useful in the setting of malignancy-related bleeding."3.83Aminocaproic acid use in hospitalized patients with hematological malignancy: a case series. ( Drucker, A; Dzik, W; Li, A; Marshall, A, 2016)
"Epsilon aminocaproic acid (EACA) is an antifibrinolytic drug that has been used to control hemorrhage by stabilizing the thrombus."3.73Epsilon aminocaproic acid reduces transfusion requirements in patients with thrombocytopenic hemorrhage. ( Jin, T; Kalaycio, M; Kalmadi, S; Lowe, C; Tiu, R, 2006)
"To report a case of rhabdomyolysis associated with epsilon-aminocaproic acid (epsilon-ACA)."3.69Rhabdomyolysis induced by epsilon-aminocaproic acid. ( Rubinger, M; Seymour, BD, 1997)

Research

Studies (30)

TimeframeStudies, this research(%)All Research%
pre-199015 (50.00)18.7374
1990's7 (23.33)18.2507
2000's1 (3.33)29.6817
2010's7 (23.33)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Twohig, P1
Rivington, J1
Juhl, RC1
Roddy, JVF1
Wang, TF1
Li, J1
Elefritz, JL1
Shakir, AK1
Yu, Z1
Altaf, MA1
Wardrop, D1
Estcourt, LJ2
Brunskill, SJ2
Doree, C2
Trivella, M1
Stanworth, S1
Murphy, MF2
Antun, AG1
Gleason, S1
Arellano, M1
Langston, AA1
McLemore, ML1
Gaddh, M1
el Rassi, F1
Bernal-Mizrachi, L1
Galipeau, J1
Heffner, LT1
Winton, EF1
Khoury, HJ1
Marshall, A1
Li, A1
Drucker, A1
Dzik, W1
Desborough, M1
Hopewell, S1
Stanworth, SJ1
FIEHRER, A1
CATTAN, A1
SCHWARZENBERG, L1
SCHNEIDER, M1
AMIEL, JL1
MATHE, G1
GROSSI, CE1
ROUSSELOT, LM1
PANKE, WF1
CROIZAT, P1
REVOL, L1
SHIMIZU, M1
HAYASHI, H1
UIHLEIN, A1
OWEN, CA1
COOPER, T1
THOMPSON, JH1
MANDELLI, F1
DERIU, L1
OMODEI-ZORINI, C1
SHARP, AA1
SVENNINGSEN, NW1
Kalmadi, S1
Tiu, R1
Lowe, C1
Jin, T1
Kalaycio, M1
Vranovská, J1
Pospísil, J1
Benson, K1
Fields, K1
Hiemenz, J1
Zorsky, P1
Ballester, O1
Perkins, J1
Elfenbein, G1
Seymour, BD1
Rubinger, M1
Chakrabarti, S1
Varma, S1
Singh, S1
Kumari, S1
Fernández-Liesa, JI1
Adame, M1
Muñoz, C1
Mendieta, JM1
Panadero, A1
Calderón, R1
Sistino, JJ1
Richards, C1
Peng, TC1
Kickler, TS1
Bell, WR1
Haller, E1
Randall, J1
Taylor, K1
Poon, MC1
Kloiber, R1
Birdsell, DC1
Molina, M1
Ortega, G1
Pérez Gracia, A1
Bermudo, J1
Ortel, TL1
Onorato, JJ1
Bedrosian, CL1
Kaufman, RE1
Gallardo, RL1
Gardner, FH1
Garewal, HS1
Durie, BG1

Reviews

4 reviews available for aminocaproic acid and Thrombopenia

ArticleYear
Antifibrinolytics (lysine analogues) for the prevention of bleeding in patients with haematological disorders.
    The Cochrane database of systematic reviews, 2013, Jul-29, Issue:7

    Topics: Aminocaproic Acid; Antifibrinolytic Agents; Erythrocyte Transfusion; Hematologic Diseases; Hemorrhag

2013
Antifibrinolytics (lysine analogues) for the prevention of bleeding in people with haematological disorders.
    The Cochrane database of systematic reviews, 2016, Mar-15, Volume: 3

    Topics: Aminocaproic Acid; Antifibrinolytic Agents; Erythrocyte Transfusion; Hematologic Diseases; Hemorrhag

2016
PATHOLOGICAL FIBRINOLYSIS.
    British medical bulletin, 1964, Volume: 20

    Topics: Aminocaproates; Aminocaproic Acid; Anticoagulants; Blood Coagulation Disorders; Blood Group Incompat

1964
The platelet-refractory bone marrow transplant patient: prophylaxis and treatment of bleeding.
    Seminars in oncology, 1993, Volume: 20, Issue:5 Suppl 6

    Topics: Aminocaproic Acid; Blood Platelets; Bone Marrow Transplantation; Hemorrhage; Humans; Neoplasms; Plat

1993

Other Studies

26 other studies available for aminocaproic acid and Thrombopenia

ArticleYear
Platelet Count of Zero: A Curious Case of Thrombocytopenia.
    The American journal of medicine, 2017, Volume: 130, Issue:11

    Topics: Aminocaproic Acid; Antifibrinolytic Agents; Dexamethasone; Female; Herpesvirus 4, Human; Humans; Imm

2017
Thromboembolic complications following aminocaproic acid use in patients with hematologic malignancies.
    Leukemia & lymphoma, 2018, Volume: 59, Issue:10

    Topics: Adult; Aged; Aminocaproic Acid; Antifibrinolytic Agents; Catheterization, Central Venous; Catheters,

2018
Long-term Complications and Management of Gastrointestinal Bleeding in Multifocal Lymphangioendotheliomatosis.
    Journal of pediatric hematology/oncology, 2019, Volume: 41, Issue:8

    Topics: Adrenal Cortex Hormones; Aminocaproic Acid; Gastrointestinal Hemorrhage; Humans; Infant; Lymphangiom

2019
Epsilon aminocaproic acid prevents bleeding in severely thrombocytopenic patients with hematological malignancies.
    Cancer, 2013, Nov-01, Volume: 119, Issue:21

    Topics: Administration, Oral; Adolescent; Adult; Aged; Aged, 80 and over; Aminocaproic Acid; Antifibrinolyti

2013
Aminocaproic acid use in hospitalized patients with hematological malignancy: a case series.
    Hematological oncology, 2016, Volume: 34, Issue:3

    Topics: Administration, Intravenous; Adult; Aged; Aged, 80 and over; Aminocaproic Acid; Female; Hematologic

2016
[SEVERE HEMORRHAGIC PURPURA IN AN 89-YEAR-OLD MAN. SPECTACULAR CURE BY INTRAVENOUS INJECTIONS OF EPSILON-AMINOCAPROIC ACID].
    Revue de pathologie generale et de physiologie clinique, 1963, Volume: 63

    Topics: Aminocaproates; Aminocaproic Acid; Geriatrics; Humans; Injections, Intravenous; Male; Purpura; Purpu

1963
[TRIAL TREATMENT BY EPSILON-AMINOCAPROIC ACID OF PATIENTS WITH HEMORRHAGIC SYNDROMES, ESPECIALLY SYNDROMES RELATED TO A THROMBOCYTOPENIA].
    La Presse medicale, 1963, Oct-19, Volume: 71

    Topics: Aminocaproates; Aminocaproic Acid; Anemia; Anemia, Aplastic; Humans; Leukemia; Leukemia, Lymphoid; L

1963
CONTROL OF FIBRINOLYSIS DURING PORTACAVAL SHUNTS. STUDY OF PATIENTS WITH CIRRHOSIS OF THE LIVER.
    JAMA, 1964, Mar-28, Volume: 187

    Topics: Afibrinogenemia; Aminocaproates; Aminocaproic Acid; Fibrinolysis; Humans; Hypersplenism; Hypertensio

1964
[APROPOS OF A COMPLEX HEMORRHAGIC SYNDROME TREATED WITH EPSILON-AMINOCAPROIC ACID].
    Lyon medical, 1964, Feb-16, Volume: 211

    Topics: Afibrinogenemia; Aminocaproates; Aminocaproic Acid; Fibrinolysis; Geriatrics; Humans; Hypoprothrombi

1964
[HEMORRHAGIC DIATHESIS AND THE PHENOMENON OF FIBRINOLYSIS, WITH SPECIAL REFERENCE TO ITS INHIBITION].
    [Chiryo] [Therapy], 1964, Volume: 46

    Topics: Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Aminocaproates; Aminocaproic Acid; Ascorbic Ac

1964
BLEEDING TENDENCIES ASSOCIATED WITH PROFOUND-HYPOTHERMIA TECHNICS IN NEUROLOGIC SURGERY.
    Annals of the New York Academy of Sciences, 1964, Jul-09, Volume: 115

    Topics: Aminocaproates; Aminocaproic Acid; Blood Coagulation Disorders; Fibrinogen; Heart, Artificial; Hemos

1964
[PRELIMINARY OBSERVATIONS ON THE THERAPEUTIC EFFICACY OF EPSILON-AMINO-CAPROIC ACID IN HEMORRHAGIC SYNDROMES DUE TO BLOOD PLATELET DEFECTS].
    Il Policlinico. Sezione pratica, 1964, Sep-28, Volume: 71

    Topics: Aminocaproates; Aminocaproic Acid; Blood Platelet Disorders; Blood Platelets; Caproates; Child; Hemo

1964
THROMBOCYTOPENIA AFTER RUBELLA (REPORT OF TWO CASES).
    Acta paediatrica Scandinavica, 1965, Volume: 54

    Topics: Aminocaproates; Aminocaproic Acid; Child; Drug Therapy; Epistaxis; Hematuria; Humans; Pathology; Pre

1965
Epsilon aminocaproic acid reduces transfusion requirements in patients with thrombocytopenic hemorrhage.
    Cancer, 2006, Jul-01, Volume: 107, Issue:1

    Topics: Adult; Aged; Aged, 80 and over; Aminocaproic Acid; Antifibrinolytic Agents; Blood Transfusion; Femal

2006
Changes of the activity of acid phosphatase and beta-glucuronidase in isolated platelets of whole-body irradiated rats.
    Strahlentherapie, 1983, Volume: 159, Issue:9

    Topics: Acid Phosphatase; Aminocaproic Acid; Animals; Aprotinin; Blood Platelets; Glucuronidase; Male; Rats;

1983
Rhabdomyolysis induced by epsilon-aminocaproic acid.
    The Annals of pharmacotherapy, 1997, Volume: 31, Issue:1

    Topics: Adult; Aminocaproic Acid; Antifibrinolytic Agents; Aspartate Aminotransferases; Creatine Kinase; Fat

1997
Low dose bolus aminocaproic acid: an alternative to platelet transfusion in thrombocytopenia?
    European journal of haematology, 1998, Volume: 60, Issue:5

    Topics: Adolescent; Adult; Aged; Aminocaproic Acid; Antifibrinolytic Agents; Humans; Middle Aged; Platelet T

1998
[Common variable immunodeficiency associated with autoimmune thrombocytopenia: anesthetic management].
    Revista espanola de anestesiologia y reanimacion, 1998, Volume: 45, Issue:10

    Topics: Adjuvants, Anesthesia; Adult; Aminocaproic Acid; Androstanols; Anesthesia, Inhalation; Anesthetics;

1998
The additive effects of antifibrinolytics: dangers in the OR.
    The journal of extra-corporeal technology, 1999, Volume: 31, Issue:2

    Topics: Aged; Aminocaproic Acid; Anticoagulants; Antifibrinolytic Agents; Blood Coagulation Tests; Drug Inte

1999
Obstetric complications in a patient with Bernard-Soulier syndrome.
    American journal of obstetrics and gynecology, 1991, Volume: 165, Issue:2

    Topics: Adult; Aminocaproic Acid; Bernard-Soulier Syndrome; Female; gamma-Globulins; Humans; Immunity, Mater

1991
Epsilon-aminocaproic acid myopathy.
    Australian and New Zealand journal of medicine, 1990, Volume: 20, Issue:6

    Topics: Adult; Aminocaproic Acid; Female; Humans; Muscular Diseases; Thrombocytopenia

1990
Epsilon-aminocaproic acid in the reversal of consumptive coagulopathy with platelet sequestration in a vascular malformation of Klippel-Trenaunay syndrome.
    The American journal of medicine, 1989, Volume: 87, Issue:2

    Topics: Adolescent; Aminocaproates; Aminocaproic Acid; Angiomatosis; Disseminated Intravascular Coagulation;

1989
[The Kasabach-Merrit syndrome treated with aminocaproic acid].
    Medicina clinica, 1989, Sep-09, Volume: 93, Issue:6

    Topics: Adult; Aminocaproates; Aminocaproic Acid; Female; Hemangioma; Humans; Mediastinal Neoplasms; Syndrom

1989
Antifibrinolytic therapy in the management of the Kasabach Merritt syndrome.
    American journal of hematology, 1988, Volume: 29, Issue:1

    Topics: Adult; Aminocaproic Acid; Anemia, Hemolytic; Antifibrinolytic Agents; Arm; Blood Cell Count; Blood T

1988
Aminocaproic acid for bleeding in thrombocytopenic patients.
    Texas medicine, 1985, Volume: 81, Issue:1

    Topics: Aminocaproates; Aminocaproic Acid; Hemorrhage; Humans; Thrombocytopenia

1985
Anti-fibrinolytic therapy with aminocaproic acid for the control of bleeding in thrombocytopenic patients.
    Scandinavian journal of haematology, 1985, Volume: 35, Issue:5

    Topics: Adult; Aminocaproates; Aminocaproic Acid; Antineoplastic Agents; Female; Fibrinolysis; Hemorrhage; H

1985