Page last updated: 2024-10-17

aminocaproic acid and Subarachnoid Hemorrhage

aminocaproic acid has been researched along with Subarachnoid Hemorrhage in 55 studies

Aminocaproic Acid: An antifibrinolytic agent that acts by inhibiting plasminogen activators which have fibrinolytic properties.
6-aminohexanoic acid : An epsilon-amino acid comprising hexanoic acid carrying an amino substituent at position C-6. Used to control postoperative bleeding, and to treat overdose effects of the thrombolytic agents streptokinase and tissue plasminogen activator.

Subarachnoid Hemorrhage: Bleeding into the intracranial or spinal SUBARACHNOID SPACE, most resulting from INTRACRANIAL ANEURYSM rupture. It can occur after traumatic injuries (SUBARACHNOID HEMORRHAGE, TRAUMATIC). Clinical features include HEADACHE; NAUSEA; VOMITING, nuchal rigidity, variable neurological deficits and reduced mental status.

Research Excerpts

ExcerptRelevanceReference
"A double-blind clinical trial of tranexamic acid was carried out on 39 patients with fresh subarachnoid hemorrhage from a ruptured aneurysm."9.04Treatment of subarachnoid hemorrhage from ruptured intracranial aneurysm with tranexamic acid: a double-blind clinical trial. ( Chandra, B, 1978)
"5 g of epsilon-aminocaproic acid (EACA) per hour after subarachnoid hemorrhage (SAH) from an intracranial aneurysm."7.67Quantitative determination of plasma fibrinolytic activity in patients with ruptured intracranial aneurysms who are receiving epsilon-aminocaproic acid: relationship of possible complications of therapy to the degree of fibrinolytic inhibition. ( Bakay, RA; Burchiel, KJ; Hoffman, JM, 1984)
"Epsilon aminocaproic acid (EACA) has been used to prevent rebleeding in patients with subarachnoid hemorrhage (SAH)."7.66Recurrent subarachnoid hemorrhage associated with aminocaproic acid therapy and acute renal artery thrombosis. Case report. ( Benjamin, SP; Dohn, DE; Tubbs, RR, 1979)
"ε-Aminocaproic acid (EACA) has been used to reduce the rate of cerebral aneurysm rerupture before definitive treatment."5.38ε-Aminocaproic acid in angiographically negative subarachnoid hemorrhage patients is safe: a retrospective review of 83 consecutive patients. ( Barrow, DL; Cawley, CM; Hui, FK; Lieber, M; Moskowitz, SI; Schuette, AJ; Spiotta, AM, 2012)
"A double-blind clinical trial of tranexamic acid was carried out on 39 patients with fresh subarachnoid hemorrhage from a ruptured aneurysm."5.04Treatment of subarachnoid hemorrhage from ruptured intracranial aneurysm with tranexamic acid: a double-blind clinical trial. ( Chandra, B, 1978)
"We sought trials or observational studies of ≥20 adults involving any antifibrinolytic drug (TXA, epsilonaminocaproic acid (EACA) or aprotinin) for spontaneous (non-traumatic, non-surgical/iatrogenic), non-heamophiliac bleeding."4.88The frequency of thrombotic events among adults given antifibrinolytic drugs for spontaneous bleeding: systematic review and meta-analysis of observational studies and randomized trials. ( Al-Shahi Salman, R; Ross, J, 2012)
"Long-term administration of the antifibrinolytic agent epsilon aminocaproic acid (EACA) reduces the rate of rehemorrhage in patients with aneurysmal subarachnoid hemorrhage (SAH), but is associated with cerebral ischemia."3.76Short-term antifibrinolytic therapy before early aneurysm treatment in subarachnoid hemorrhage: effects on rehemorrhage, cerebral ischemia, and hydrocephalus. ( Ardelt, AA; Fisher, WS; Harrigan, MR; Rajneesh, KF, 2010)
"epsilon-Aminocaproic acid (EACA) is an antifibrinolytic agent used to prevent rebleeding in aneurysmal subarachnoid hemorrhage."3.74Impact of a protocol for acute antifibrinolytic therapy on aneurysm rebleeding after subarachnoid hemorrhage. ( Chwajol, M; Connolly, ES; Ducruet, AF; Fernandez, A; Hahn, DK; Hickman, ZL; Kellner, CP; Kim, GH; Komotar, RJ; Mayer, SA; Otten, ML; Starke, RM, 2008)
"5 g of epsilon-aminocaproic acid (EACA) per hour after subarachnoid hemorrhage (SAH) from an intracranial aneurysm."3.67Quantitative determination of plasma fibrinolytic activity in patients with ruptured intracranial aneurysms who are receiving epsilon-aminocaproic acid: relationship of possible complications of therapy to the degree of fibrinolytic inhibition. ( Bakay, RA; Burchiel, KJ; Hoffman, JM, 1984)
"The incidence and severity of cerebral vasospasm and hydrocephalus following induced subarachnoid hemorrhage in an experimental group of animals that subsequently received epsilon-aminocaproic acid was compared to that seen in a control group that received no antifibrinolytic therapy."3.67An experimental study of the influence of antifibrinolytic therapy on post-subarachnoid-hemorrhagic cerebral vasospasm and hydrocephalus. ( Dujovny, M; Heros, RC; Kenning, JA; Latchaw, RE; Nelson, D, 1984)
"We previously reported that epsilon-aminocaproic acid (EACA) prolonged the bleeding time in patients with intracranial aneurysms when given in doses of 36 to 48 gm/day."3.67Clinical and laboratory investigation of the effects of epsilon-aminocaproic acid on hemostasis. ( Atkinson, AJ; Cerullo, L; Cohen, I; Green, D; Ruo, TI; Ts'ao, CH, 1985)
"Patients suffering from a subarachnoid hemorrhage who were admitted to the Neurosurgical Unit of the Royal Perth Hospital during the period 1971 to 1979 were assessed with regard to the effectiveness of preoperative treatment with epsilon-aminocaproic acid, kanamycin, and reserpine."3.66Medical management of patients following a ruptured cerebral aneurysm, with epsilon-aminocaproic acid, kanamycin, and reserpine. ( Knuckey, NW; Stokes, BA, 1982)
"One hundred consecutive patients treated with epsilon aminocaproic acid 24 grams daily prior to surgery for ruptured intracranial aneurysms have been compared with the previous 100 patients managed similarly but without anti-fibrinolytic drugs."3.66Anti-fibrinolytic treatment in the pre-operative management of subarachnoid haemorrhage caused by ruptured intracranial aneurysm. ( Ameen, AA; Illingworth, R, 1981)
"A rapid fluorometric assay technique has been utilized to assess the degree of fibrinolytic inhibition in 20 patients with ruptured intracranial aneurysms treated with epsilon-aminocaproic acid (EACA)."3.66A method for monitoring antifibrinolytic therapy in patients with ruptured intracranial aneurysms. ( Burchiel, KJ; Schmer, G, 1981)
"Amicar (epsilon-aminocaproic acid) has been used in patients with subarachnoid hemorrhage to promote clotting."3.66Cerebral thrombosis associated with Amicar therapy. ( Hoffman, EP; Koo, AH, 1979)
"Epsilon aminocaproic acid (EACA) has been used to prevent rebleeding in patients with subarachnoid hemorrhage (SAH)."3.66Recurrent subarachnoid hemorrhage associated with aminocaproic acid therapy and acute renal artery thrombosis. Case report. ( Benjamin, SP; Dohn, DE; Tubbs, RR, 1979)
"10 patients suffering from intracranial aneurysm causing subarachnoid hemorrhage (SAH) have been treated during the acute pre-and postoperatory phase with omega-aminocaproic acid."3.66Fibrinolytic activity in blood and cerebrospinal fluid in subarachnoid hemorrhage from ruptured intracranial saccular aneurysm before and during EACA treatment. ( Collice, M; D'angelo, V; Donati, MB; Ferrara, M; Filizzolo, F; Porta, M, 1978)
"The association of myopathy with epsilon-aminocaproic acid (EACA) treatment after subarachnoid hemorrhage in two cases is reported."3.66Myopathy associated with epsilon-aminocaproic acid (EACA) therapy. Report of two cases. ( MacKay, AR; Sang U, H; Weinstein, PR, 1978)
"ε-Aminocaproic acid (EACA) has been used to reduce the rate of cerebral aneurysm rerupture before definitive treatment."1.38ε-Aminocaproic acid in angiographically negative subarachnoid hemorrhage patients is safe: a retrospective review of 83 consecutive patients. ( Barrow, DL; Cawley, CM; Hui, FK; Lieber, M; Moskowitz, SI; Schuette, AJ; Spiotta, AM, 2012)
"The incidence of hydrocephalus or symptomatic vasospasm was not unduly elevated in patients receiving preoperative EACA."1.30Reducing the risk of rebleeding before early aneurysm surgery: a possible role for antifibrinolytic therapy. ( Horner, TG; Leipzig, TJ; Redelman, K, 1997)
"Ten cases of subarachnoid hemorrhage (SAH) from ruptured cerebral aneurysm are reported."1.27Monitoring of antifibrinolytic therapy following subarachnoid hemorrhage. The importance of CSF fibrin/fibrinogen degradation products. ( McLaurin, RL; Perrotta, G; Sawaya, R; Sonnino, V, 1983)
"An increased incidence of communicating hydrocephalus following subarachnoid hemorrhage has been observed on the neurosurgical service at Vanderbilt University Hospital during the past four years."1.26Spontaneous subarachnoid hemorrhage complicated by communicating hydrocephalus: epsilon amino caproic acid as a possible predisposing factor. ( Park, BE, 1979)
" The last 20 patients of the present series have been treated with very low doses of AMCA associated with parotid kallikrein inhibitor (Trasylol); this dosage has been effective in preventing recurrence and has appeared to be freer from severe side effects."1.26The use of antifibrinolytic drugs in aneurysmal subarachnoid hemorrhage. ( Schisano, G, 1978)

Research

Studies (55)

TimeframeStudies, this research(%)All Research%
pre-199039 (70.91)18.7374
1990's2 (3.64)18.2507
2000's1 (1.82)29.6817
2010's13 (23.64)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Jeong, HG1
Cha, BG1
Kang, DW1
Kim, DY1
Ki, SK1
Kim, SI1
Han, JH1
Yang, W1
Kim, CK1
Kim, J1
Lee, SH1
Baranoski, JF1
Ducruet, AF2
Baharoglu, MI1
Germans, MR2
Rinkel, GJ1
Algra, A1
Vermeulen, M1
van Gijn, J1
Roos, YB1
Eastin, TR1
Snipes, CD1
Seupaul, RA1
Foreman, PM1
Chua, M1
Harrigan, MR2
Fisher, WS2
Tubbs, RS1
Shoja, MM1
Griessenauer, CJ1
Malekpour, M1
Kulwin, C1
Bohnstedt, BN1
Radmand, G1
Sethia, R1
Mendenhall, SK1
Weyhenmeyer, J1
Hendricks, BK1
Leipzig, T1
Payner, TD1
Shah, MV1
Scott, J1
DeNardo, A1
Sahlein, D1
Cohen-Gadol, AA1
Post, R1
Coert, BA1
Vandertop, WP1
Verbaan, D1
Starke, RM1
Kim, GH1
Fernandez, A1
Komotar, RJ1
Hickman, ZL1
Otten, ML1
Kellner, CP1
Hahn, DK1
Chwajol, M1
Mayer, SA1
Connolly, ES1
Rajneesh, KF1
Ardelt, AA1
Nina, P2
Schisano, G3
Thomas, G1
Evelyne, E1
Hui, FK2
Schuette, AJ2
Lieber, M1
Spiotta, AM1
Moskowitz, SI1
Barrow, DL2
Cawley, CM2
Ross, J1
Al-Shahi Salman, R1
Obuchowski, NA1
Walkup, RR1
Samuels, OB1
Spallone, A1
Solomon, RA1
Post, KD1
McMurtry, JG1
Burchiel, KJ2
Hoffman, JM1
Bakay, RA1
Rosenwasser, RH1
Buchheit, WA1
Truex, RC1
Galassi, G1
Gibertoni, M1
Corradini, L1
Colombo, A1
Kenning, JA1
Heros, RC1
Dujovny, M1
Latchaw, RE1
Nelson, D1
Sawaya, R1
Sonnino, V1
McLaurin, RL1
Perrotta, G1
Yamaura, A1
Nakamura, T1
Makino, H1
Hagihara, Y1
Smith, RR1
Ramirez-Lassepas, M1
Chowdhary, UM2
Sayed, K1
Fodstad, H1
Knuckey, NW1
Stokes, BA1
Vanneste, JA1
van Wijngaarden, GK1
Ameen, AA1
Illingworth, R1
Glick, R1
Green, D2
Ts'ao, C1
Witt, WA1
Yu, AT1
Raimondi, AJ1
Britt, CW1
Light, RR1
Peters, BH1
Schochet, SS1
Alvarez Garijo, JA1
Vilches, JJ1
Aznar, JA1
Shucart, WA1
Hussain, SK1
Cooper, PR1
Biswas, CK1
Milligan, DA1
Agte, SD1
Kenward, DH1
Tilley, PJ1
Brodkin, HM1
Schmer, G1
Levati, A1
Minella, C1
Farina, ML1
D'Angelo, V2
Leipzig, TJ1
Redelman, K1
Horner, TG1
Carey, PC1
Hussein, MM1
Wintzen, AR1
Van Rossum, J1
Chandra, B1
Hoffman, EP1
Koo, AH1
Tubbs, RR1
Benjamin, SP1
Dohn, DE1
Park, BE1
Peerless, SJ1
Filizzolo, F1
Collice, M1
Ferrara, M1
Donati, MB1
Porta, M1
MacKay, AR1
Sang U, H1
Weinstein, PR1
White, RP1
Robertson, JT1
Ts'ao, CH1
Cerullo, L1
Cohen, I1
Ruo, TI1
Atkinson, AJ1
Biller, J1
Godersky, JC1
Adams, HP1
Rehák, S1
Kadanka, Z1
Novotný, O1
Penka, M1
Ruelle, A1
Lasio, G1
Boccardo, M1
Gottlieb, A1
Severi, P1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
The Intra-arterial Vasospasm Trial(iVAST)- A Multi-center Randomized Study[NCT01996436]Phase 4330 participants (Anticipated)Interventional2016-08-29Recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

4 reviews available for aminocaproic acid and Subarachnoid Hemorrhage

ArticleYear
Antifibrinolytic therapy for aneurysmal subarachnoid haemorrhage.
    The Cochrane database of systematic reviews, 2013, Aug-30, Issue:8

    Topics: Administration, Oral; Aminocaproic Acid; Antifibrinolytic Agents; Brain Ischemia; Confidence Interva

2013
The frequency of thrombotic events among adults given antifibrinolytic drugs for spontaneous bleeding: systematic review and meta-analysis of observational studies and randomized trials.
    Current drug safety, 2012, Volume: 7, Issue:1

    Topics: Adult; Aged; Aminocaproic Acid; Antifibrinolytic Agents; Aprotinin; Hemorrhage; Humans; Middle Aged;

2012
Antifibrinolytic therapy in subarachnoid hemorrhage caused by ruptured intracranial aneurysm.
    Neurology, 1981, Volume: 31, Issue:3

    Topics: Aminocaproates; Aminocaproic Acid; Cyclohexanecarboxylic Acids; Humans; Intracranial Aneurysm; Ruptu

1981
Antifibrinolytic treatment in subarachnoid haemorrhage: present state.
    Acta neurochirurgica, 1982, Volume: 63, Issue:1-4

    Topics: 4-Aminobenzoic Acid; Aminocaproic Acid; Antifibrinolytic Agents; Clinical Trials as Topic; Humans; R

1982

Trials

5 trials available for aminocaproic acid and Subarachnoid Hemorrhage

ArticleYear
EACA and subarachnoid hemorrhage.
    Journal of neurosurgery, 1981, Volume: 54, Issue:1

    Topics: Aminocaproates; Aminocaproic Acid; Clinical Trials as Topic; Humans; Recurrence; Subarachnoid Hemorr

1981
Comparative clinical trial of epsilon amino-caproic acid and tranexamic acid in the prevention of early recurrence of subarachnoid haemorrhage.
    Journal of neurology, neurosurgery, and psychiatry, 1981, Volume: 44, Issue:9

    Topics: Adolescent; Adult; Aminocaproates; Aminocaproic Acid; Clinical Trials as Topic; Cyclohexanecarboxyli

1981
Antifibrinolytic treatment in subarachnoid haemorrhage: present state.
    Acta neurochirurgica, 1982, Volume: 63, Issue:1-4

    Topics: 4-Aminobenzoic Acid; Aminocaproic Acid; Antifibrinolytic Agents; Clinical Trials as Topic; Humans; R

1982
Prevention of early recurrence of spontaneous subarachnoid haemorrhage by epsilon-aminocaproic acid.
    Lancet (London, England), 1979, Apr-07, Volume: 1, Issue:8119

    Topics: Adolescent; Adult; Aged; Aminocaproates; Aminocaproic Acid; Arteriovenous Fistula; Basilar Artery; C

1979
Treatment of subarachnoid hemorrhage from ruptured intracranial aneurysm with tranexamic acid: a double-blind clinical trial.
    Annals of neurology, 1978, Volume: 3, Issue:6

    Topics: Adult; Aged; Aminocaproic Acid; Clinical Trials as Topic; Cyclohexanecarboxylic Acids; Double-Blind

1978

Other Studies

47 other studies available for aminocaproic acid and Subarachnoid Hemorrhage

ArticleYear
Ceria Nanoparticles Synthesized With Aminocaproic Acid for the Treatment of Subarachnoid Hemorrhage.
    Stroke, 2018, Volume: 49, Issue:12

    Topics: Aminocaproic Acid; Animals; Anti-Inflammatory Agents; Brain; Brain Edema; Cell Death; Cerium; In Sit

2018
Nanoparticle-Facilitated Delivery of Antioxidant Therapy following Aneurysmal Subarachnoid Hemorrhage.
    Neurosurgery, 2019, 08-01, Volume: 85, Issue:2

    Topics: Aminocaproates; Aminocaproic Acid; Antioxidants; Humans; Nanoparticles; Subarachnoid Hemorrhage

2019
Are antifibrinolytic agents effective in the treatment of aneurysmal subarachnoid hemorrhage?
    Annals of emergency medicine, 2014, Volume: 64, Issue:6

    Topics: Aminocaproic Acid; Antifibrinolytic Agents; Humans; Subarachnoid Hemorrhage; Tranexamic Acid

2014
Antifibrinolytic therapy in aneurysmal subarachnoid hemorrhage increases the risk for deep venous thrombosis: A case-control study.
    Clinical neurology and neurosurgery, 2015, Volume: 139

    Topics: Adult; Aged; Aminocaproic Acid; Aneurysm, Ruptured; Angiography, Digital Subtraction; Antifibrinolyt

2015
Effect of short-term ε-aminocaproic acid treatment on patients undergoing endovascular coil embolization following aneurysmal subarachnoid hemorrhage.
    Journal of neurosurgery, 2017, Volume: 126, Issue:5

    Topics: Adult; Aged; Aminocaproic Acid; Aneurysm, Ruptured; Antifibrinolytic Agents; Cohort Studies; Drug Ad

2017
Letter to the Editor: Short-term ε-aminocaproic acid treatment and endovascular coil embolization.
    Journal of neurosurgery, 2017, Volume: 126, Issue:5

    Topics: Aminocaproic Acid; Blood Vessel Prosthesis; Humans; Subarachnoid Hemorrhage

2017
Impact of a protocol for acute antifibrinolytic therapy on aneurysm rebleeding after subarachnoid hemorrhage.
    Stroke, 2008, Volume: 39, Issue:9

    Topics: Acute Disease; Adult; Aged; Aminocaproic Acid; Antifibrinolytic Agents; Clinical Protocols; Drug Adm

2008
Short-term antifibrinolytic therapy before early aneurysm treatment in subarachnoid hemorrhage: effects on rehemorrhage, cerebral ischemia, and hydrocephalus.
    Neurosurgery, 2010, Volume: 67, Issue:4

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aminocaproic Acid; Antifibrinolytic Agents; Brain Ischem

2010
Antifibrinolytic drugs in subarachnoid hemorrhage by ruptured aneurysms.
    Neurosurgery, 2011, Volume: 68, Issue:6

    Topics: Aminocaproic Acid; Antifibrinolytic Agents; Brain Ischemia; Female; Humans; Hydrocephalus; Male; Sub

2011
Antifibrinolytic in subarachnoid hemorrhage.
    Neurosurgery, 2011, Volume: 69, Issue:2

    Topics: Aminocaproic Acid; Antifibrinolytic Agents; Brain Ischemia; Female; Humans; Hydrocephalus; Male; Sub

2011
ε-Aminocaproic acid in angiographically negative subarachnoid hemorrhage patients is safe: a retrospective review of 83 consecutive patients.
    Neurosurgery, 2012, Volume: 70, Issue:3

    Topics: Adult; Aminocaproic Acid; Antifibrinolytic Agents; Brain Ischemia; Case-Control Studies; Cerebral An

2012
An examination of aneurysm rerupture rates with epsilon aminocaproic acid.
    Neurocritical care, 2013, Volume: 19, Issue:1

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aminocaproic Acid; Aneurysm, Ruptured; Antifibrinolytic

2013
Antifibrinolytics in aneurysmal subarachnoid haemorrhage. A retrospective comparison of two different forms of antifibrinolytic therapy.
    Acta neurochirurgica, 1982, Volume: 63, Issue:1-4

    Topics: Adult; Aminocaproates; Aminocaproic Acid; Antifibrinolytic Agents; Aprotinin; Drug Therapy, Combinat

1982
Depression of circulating blood volume in patients after subarachnoid hemorrhage: implications for the management of symptomatic vasospasm.
    Neurosurgery, 1984, Volume: 15, Issue:3

    Topics: Adult; Aged; Aminocaproic Acid; Antifibrinolytic Agents; Blood Volume; Cerebral Angiography; Dexamet

1984
Quantitative determination of plasma fibrinolytic activity in patients with ruptured intracranial aneurysms who are receiving epsilon-aminocaproic acid: relationship of possible complications of therapy to the degree of fibrinolytic inhibition.
    Neurosurgery, 1984, Volume: 14, Issue:1

    Topics: Adolescent; Adult; Aged; Aminocaproates; Aminocaproic Acid; Cerebral Arteries; Depression, Chemical;

1984
Management of subarachnoid hemorrhage.
    Pennsylvania medicine, 1984, Volume: 87, Issue:12

    Topics: Adolescent; Adult; Aminocaproic Acid; Antihypertensive Agents; Child; Cimetidine; Dexamethasone; Hum

1984
Why may epsilon-aminocaproic acid (EACA) induce myopathy in man? Report of a case and literature review.
    Italian journal of neurological sciences, 1983, Volume: 4, Issue:4

    Topics: Aged; Aminocaproates; Aminocaproic Acid; Biopsy; Female; Humans; Muscles; Muscular Diseases; Necrosi

1983
An experimental study of the influence of antifibrinolytic therapy on post-subarachnoid-hemorrhagic cerebral vasospasm and hydrocephalus.
    Surgical neurology, 1984, Volume: 21, Issue:2

    Topics: Aminocaproates; Aminocaproic Acid; Animals; Cerebral Angiography; Cerebral Hemorrhage; Hydrocephalus

1984
Monitoring of antifibrinolytic therapy following subarachnoid hemorrhage. The importance of CSF fibrin/fibrinogen degradation products.
    Journal of neurosurgery, 1983, Volume: 58, Issue:5

    Topics: Adult; Aged; Aminocaproates; Aminocaproic Acid; Antifibrinolytic Agents; Female; Fibrin Fibrinogen D

1983
Cerebral complication of antifibrinolytic therapy in the treatment of ruptured intracranial aneurysm. Animal experiment and a review of literature.
    European neurology, 1980, Volume: 19, Issue:2

    Topics: Aminocaproates; Aminocaproic Acid; Animals; Blood Pressure; Cerebral Cortex; Cisterna Magna; Cyclohe

1980
Medical management of patients following a ruptured cerebral aneurysm, with epsilon-aminocaproic acid, kanamycin, and reserpine.
    Surgical neurology, 1982, Volume: 17, Issue:3

    Topics: Aminocaproates; Aminocaproic Acid; Drug Therapy, Combination; Female; Humans; Intracranial Aneurysm;

1982
Epsilon-aminocaproic acid myopathy. Report of a case and literature review.
    European neurology, 1982, Volume: 21, Issue:4

    Topics: Adult; Aminocaproates; Aminocaproic Acid; Biopsy; Electromyography; Humans; Male; Muscles; Myoglobin

1982
Anti-fibrinolytic treatment in the pre-operative management of subarachnoid haemorrhage caused by ruptured intracranial aneurysm.
    Journal of neurology, neurosurgery, and psychiatry, 1981, Volume: 44, Issue:3

    Topics: Adolescent; Adult; Aged; Aminocaproates; Aminocaproic Acid; Antifibrinolytic Agents; Child; Female;

1981
High does epsilon-aminocaproic acid prolongs the bleeding time and increases rebleeding and intraoperative hemorrhage in patients with subarachnoid hemorrhage.
    Neurosurgery, 1981, Volume: 9, Issue:4

    Topics: Adult; Aged; Aminocaproates; Aminocaproic Acid; Bleeding Time; Blood Coagulation; Female; Humans; In

1981
Rhabdomyolysis during treatment with epsilon-aminocaproic acid.
    Archives of neurology, 1980, Volume: 37, Issue:3

    Topics: Adult; Aminocaproates; Aminocaproic Acid; Female; Humans; Muscles; Muscular Diseases; Myoglobinuria;

1980
Preoperative treatment of ruptured intracranial aneurysms with tranexamic acid and monitoring of fibrinolytic activity.
    Journal of neurosurgery, 1980, Volume: 52, Issue:4

    Topics: Aminocaproic Acid; Cyclohexanecarboxylic Acids; Fibrin Fibrinogen Degradation Products; Humans; Intr

1980
Epsilon-aminocaproic acid and recurrent subarachnoid hemorrhage: a clinical trial.
    Journal of neurosurgery, 1980, Volume: 53, Issue:1

    Topics: Aminocaproates; Aminocaproic Acid; Drug Evaluation; Humans; Intracranial Aneurysm; Recurrence; Subar

1980
Acute renal failure and myopathy after treatment with aminocaproic acid.
    British medical journal, 1980, Jul-12, Volume: 281, Issue:6233

    Topics: Acute Kidney Injury; Adult; Aminocaproates; Aminocaproic Acid; Aspartate Aminotransferases; Creatine

1980
Myoglobinuria following epsilon-aminocaproic acid (EACA) therapy. Case report.
    Journal of neurosurgery, 1980, Volume: 53, Issue:5

    Topics: Aminocaproates; Aminocaproic Acid; Female; Humans; Middle Aged; Myoglobinuria; Subarachnoid Hemorrha

1980
A method for monitoring antifibrinolytic therapy in patients with ruptured intracranial aneurysms.
    Journal of neurosurgery, 1981, Volume: 54, Issue:1

    Topics: Aminocaproates; Aminocaproic Acid; Humans; Injections, Intravenous; Intracranial Aneurysm; Plasminog

1981
Potential hazards of antifibrinolytic treatment in subarachnoid haemorrhage.
    Thrombosis and haemostasis, 1980, Dec-19, Volume: 44, Issue:3

    Topics: Aminocaproates; Aminocaproic Acid; Coronary Disease; Humans; Male; Middle Aged; Pulmonary Embolism;

1980
Reducing the risk of rebleeding before early aneurysm surgery: a possible role for antifibrinolytic therapy.
    Journal of neurosurgery, 1997, Volume: 86, Issue:2

    Topics: Adult; Aged; Aged, 80 and over; Aminocaproic Acid; Aneurysm, Ruptured; Antifibrinolytic Agents; Huma

1997
Antifibrinolytic therapy.
    Journal of neurosurgery, 1997, Volume: 87, Issue:3

    Topics: Aminocaproic Acid; Antifibrinolytic Agents; Humans; Recurrence; Subarachnoid Hemorrhage; Tranexamic

1997
epsilon-aminocaproic acid in prevention of subarachnoid haemorrhage.
    Lancet (London, England), 1979, May-19, Volume: 1, Issue:8125

    Topics: Aminocaproates; Aminocaproic Acid; Drug Evaluation; Humans; Subarachnoid Hemorrhage

1979
Cerebral thrombosis associated with Amicar therapy.
    Radiology, 1979, Volume: 131, Issue:3

    Topics: Adult; Aminocaproates; Aminocaproic Acid; Cerebral Angiography; Female; Humans; Intracranial Embolis

1979
Recurrent subarachnoid hemorrhage associated with aminocaproic acid therapy and acute renal artery thrombosis. Case report.
    Journal of neurosurgery, 1979, Volume: 51, Issue:1

    Topics: Acute Disease; Aged; Aminocaproates; Aminocaproic Acid; Female; Humans; Recurrence; Renal Artery; Su

1979
Spontaneous subarachnoid hemorrhage complicated by communicating hydrocephalus: epsilon amino caproic acid as a possible predisposing factor.
    Surgical neurology, 1979, Volume: 11, Issue:1

    Topics: Adult; Aged; Aminocaproates; Aminocaproic Acid; Angiography; Animals; Cerebral Ventricles; Dogs; Fem

1979
Pre- and postoperative management of cerebral aneurysms.
    Clinical neurosurgery, 1979, Volume: 26

    Topics: Aminocaproic Acid; Brain Edema; Humans; Hydrocephalus; Hypertension; Intracranial Aneurysm; Ischemic

1979
Fibrinolytic activity in blood and cerebrospinal fluid in subarachnoid hemorrhage from ruptured intracranial saccular aneurysm before and during EACA treatment.
    European neurology, 1978, Volume: 17, Issue:1

    Topics: Aminocaproates; Aminocaproic Acid; Fibrin Fibrinogen Degradation Products; Fibrinolysis; Humans; Int

1978
Myopathy associated with epsilon-aminocaproic acid (EACA) therapy. Report of two cases.
    Journal of neurosurgery, 1978, Volume: 49, Issue:4

    Topics: Adult; Aminocaproates; Aminocaproic Acid; Female; Humans; Male; Middle Aged; Muscular Diseases; Suba

1978
The use of antifibrinolytic drugs in aneurysmal subarachnoid hemorrhage.
    Surgical neurology, 1978, Volume: 10, Issue:4

    Topics: Adolescent; Adult; Aged; Aminocaproates; Aminocaproic Acid; Cyclohexanecarboxylic Acids; Humans; Int

1978
Role of plasmin, thrombin, and antithrombin III as etiological factors in delayed cerebral vasospasm.
    Neurosurgery, 1985, Volume: 16, Issue:1

    Topics: Aminocaproic Acid; Animals; Antithrombin III; Aprotinin; Basilar Artery; Dogs; Female; Fibrinogen; F

1985
Clinical and laboratory investigation of the effects of epsilon-aminocaproic acid on hemostasis.
    The Journal of laboratory and clinical medicine, 1985, Volume: 105, Issue:3

    Topics: Aminocaproates; Aminocaproic Acid; Animals; Aorta, Thoracic; Bleeding Time; Blood Platelets; Cattle;

1985
Management of aneurysmal subarachnoid hemorrhage.
    Stroke, 1988, Volume: 19, Issue:10

    Topics: Aminocaproic Acid; Humans; Intracranial Aneurysm; Nervous System Diseases; Nicardipine; Nimodipine;

1988
[Preoperative care and treatment of acute subarachnoid hemorrhage].
    Sbornik vedeckych praci Lekarske fakulty Karlovy univerzity v Hradci Kralove. Supplementum, 1987, Volume: 30, Issue:2

    Topics: Adolescent; Adult; Aged; Aminocaproic Acid; Fibrinolysis; Humans; Middle Aged; Preoperative Care; Re

1987
[The effect of epsilon-aminocaproic acid on hemocoagulation in subarachnoid hemorrhage. Preliminary study].
    Ceskoslovenska neurologie a neurochirurgie, 1986, Volume: 49, Issue:5

    Topics: Adult; Aged; Aminocaproates; Aminocaproic Acid; Blood Coagulation; Female; Humans; Male; Middle Aged

1986
Long-term prognosis of subarachnoid hemorrhages of unknown etiology.
    Journal of neurology, 1985, Volume: 232, Issue:5

    Topics: Adult; Aged; Aminocaproic Acid; Cerebral Angiography; Female; Follow-Up Studies; Humans; Hypertensio

1985