Page last updated: 2024-10-17

aminocaproic acid and Stomach Ulcer

aminocaproic acid has been researched along with Stomach Ulcer in 15 studies

Aminocaproic Acid: An antifibrinolytic agent that acts by inhibiting plasminogen activators which have fibrinolytic properties.
6-aminohexanoic acid : An epsilon-amino acid comprising hexanoic acid carrying an amino substituent at position C-6. Used to control postoperative bleeding, and to treat overdose effects of the thrombolytic agents streptokinase and tissue plasminogen activator.

Stomach Ulcer: Ulceration of the GASTRIC MUCOSA due to contact with GASTRIC JUICE. It is often associated with HELICOBACTER PYLORI infection or consumption of nonsteroidal anti-inflammatory drugs (NSAIDS).

Research Excerpts

ExcerptRelevanceReference
"9% for indomethacin-induced acute gastric ulcer (IAGU) rats, respectively] than those of ZAC alone due to the significantly slower renal clearance (CL(R))."7.77Pharmacokinetic interaction between ϵ-acetamidocaproic acid (AACA) and cimetidine in indomethacin-induced acute gastric ulcer and control rats: inhibition of active renal secretion of AACA by cimetidine. ( Choi, YH; Kim, YG; Lee, M; Lee, MG; Lee, U; Oh, E; Suh, JH, 2011)
"The pharmacokinetics of ϵ-acetamidocaproic acid (AACA) were evaluated after the intravenous and oral administration of an antiulcer agent, zinc acexamate (ZAC) at a dose of 20 mg kg⁻¹ (ion pairing between zinc and AACA) in rats with indomethacin-induced acute gastric ulcer (IAGU) or indomethacin-induced small bowel inflammation (ISBI)."3.78ε-Acetamidocaproic acid pharmacokinetics in rats with gastric ulcer or small bowel inflammation. ( Choi, YH; Kim, YG; Lee, BK; Lee, MG; Lee, U; Oh, E, 2012)
"9% for indomethacin-induced acute gastric ulcer (IAGU) rats, respectively] than those of ZAC alone due to the significantly slower renal clearance (CL(R))."3.77Pharmacokinetic interaction between ϵ-acetamidocaproic acid (AACA) and cimetidine in indomethacin-induced acute gastric ulcer and control rats: inhibition of active renal secretion of AACA by cimetidine. ( Choi, YH; Kim, YG; Lee, M; Lee, MG; Lee, U; Oh, E; Suh, JH, 2011)
"The antiulcerogenic effect of zinc acexamate on gastric ulcers induced by reserpine and changes in the morphology of gastric mucosa were studied in rats by histochemical methods."3.68Protective effect of zinc acexamate on experimental gastric ulcers: a histochemical study. ( Barbarino, F; Brilinschi, C; Toganel, E, 1992)

Research

Studies (15)

TimeframeStudies, this research(%)All Research%
pre-19906 (40.00)18.7374
1990's6 (40.00)18.2507
2000's0 (0.00)29.6817
2010's2 (13.33)24.3611
2020's1 (6.67)2.80

Authors

AuthorsStudies
Ding, Y1
Meng, R1
Yin, H1
Hou, Z1
Sun, C1
Liu, W1
Hao, S1
Pan, Y1
Wang, B1
Choi, YH2
Lee, U2
Suh, JH1
Kim, YG2
Lee, M1
Oh, E2
Lee, MG2
Lee, BK1
Navarro, C7
Bravo, ML2
Carulla, C1
Bulbena, O8
Lapenna, D1
Cuccurullo, F1
Bravo, L2
Barbarino, F1
Toganel, E1
Brilinschi, C1
Escolar, G6
Fontarnau, R1
Jiménez, E1
Galmés, JL1
Casanovas, LI1
Pérez Mota, A1
Pérez Muñoz, C1
Casanova Cánovas, A1
Pérez Fernández, E1
Pfeiffer, CJ1
Esplugues, JV2
Esplugues, J2
Camarasa, J1
Vernetta, C1
Pavlovskiĭ, DP1
Shuliarenko, VA1
Ovsianko, IuI1
Martí-Bonmatí, E1

Trials

1 trial available for aminocaproic acid and Stomach Ulcer

ArticleYear
[Acute and prophylactic treatment of peptic ulcer with zinc acexamate or cimetidine].
    Medicina clinica, 1986, Dec-13, Volume: 87, Issue:20

    Topics: Aminocaproates; Aminocaproic Acid; Cimetidine; Clinical Trials as Topic; Duodenal Ulcer; Humans; Ran

1986

Other Studies

14 other studies available for aminocaproic acid and Stomach Ulcer

ArticleYear
Keratin-A6ACA NPs for gastric ulcer diagnosis and repair.
    Journal of materials science. Materials in medicine, 2021, Jun-12, Volume: 32, Issue:6

    Topics: Aminocaproic Acid; Animals; Cytoskeleton; Endoscopy; Female; Fluorescent Dyes; Gastric Juice; Hair;

2021
Pharmacokinetic interaction between ϵ-acetamidocaproic acid (AACA) and cimetidine in indomethacin-induced acute gastric ulcer and control rats: inhibition of active renal secretion of AACA by cimetidine.
    Xenobiotica; the fate of foreign compounds in biological systems, 2011, Volume: 41, Issue:5

    Topics: Administration, Oral; Aminocaproates; Aminocaproic Acid; Animals; Anti-Ulcer Agents; Blood Proteins;

2011
ε-Acetamidocaproic acid pharmacokinetics in rats with gastric ulcer or small bowel inflammation.
    Xenobiotica; the fate of foreign compounds in biological systems, 2012, Volume: 42, Issue:3

    Topics: Administration, Oral; Aminocaproates; Aminocaproic Acid; Animals; Anti-Ulcer Agents; Arteries; Blood

2012
Gastrotoxic activity and inhibitory effects on gastric mucosal PGE2 production with different non-steroidal anti-inflammatory drugs: modifications induced by pretreatment with zinc acexamate.
    Prostaglandins, leukotrienes, and essential fatty acids, 1994, Volume: 50, Issue:6

    Topics: Aminocaproates; Aminocaproic Acid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agen

1994
Gastroprotective effect of zinc.
    Digestive diseases and sciences, 1994, Volume: 39, Issue:9

    Topics: Aminocaproates; Aminocaproic Acid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agen

1994
[Protection by zinc acexamate against gastric lesions induced by non-steroid anti-inflammatory agents].
    Revista espanola de enfermedades digestivas, 1993, Volume: 83, Issue:3

    Topics: Aminocaproates; Aminocaproic Acid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agen

1993
Protective effect of zinc acexamate on experimental gastric ulcers: a histochemical study.
    Methods and findings in experimental and clinical pharmacology, 1992, Volume: 14, Issue:9

    Topics: Adenosine Triphosphatases; Aminocaproates; Aminocaproic Acid; Animals; Anti-Ulcer Agents; Energy Met

1992
Effect of zinc acexamate on gastric lesions induced by aspirin: a morphological study.
    European journal of pharmacology, 1990, Nov-06, Volume: 190, Issue:1-2

    Topics: Aminocaproates; Aminocaproic Acid; Animals; Anti-Ulcer Agents; Aspirin; Carrageenan; Chromatography,

1990
Effect of zinc acexamate and ranitidine on chronic gastric lesions in the rat.
    Digestion, 1990, Volume: 45, Issue:3

    Topics: Acetates; Acetic Acid; Aminocaproates; Aminocaproic Acid; Animals; Anti-Ulcer Agents; Male; Ranitidi

1990
Zinc acexamate reduces gastric damage induced by platelet-activating factor.
    Prostaglandins, leukotrienes, and essential fatty acids, 1989, Volume: 38, Issue:1

    Topics: Aminocaproates; Aminocaproic Acid; Animals; Blood Pressure; Gastric Mucosa; Male; Mast Cells; Platel

1989
Anti-ulcer and membrane stabilizing actions of zinc acexamate.
    Archives internationales de pharmacodynamie et de therapie, 1987, Volume: 285, Issue:1

    Topics: Aminocaproates; Aminocaproic Acid; Animals; Anti-Ulcer Agents; Antifibrinolytic Agents; Cell Membran

1987
Antiulcerogenic activity of zinc acexamate in different experimental models.
    Methods and findings in experimental and clinical pharmacology, 1987, Volume: 9, Issue:7

    Topics: Aminocaproates; Aminocaproic Acid; Animals; Bile Acids and Salts; Disease Models, Animal; Female; Ma

1987
[Treatment of profuse gastroduodenal hemorrhages in peptic ulcer and myocardial infarction].
    Vestnik khirurgii imeni I. I. Grekova, 1985, Volume: 135, Issue:10

    Topics: Aged; Aminocaproic Acid; Blood Transfusion; Critical Care; Duodenal Ulcer; Evaluation Studies as Top

1985
Effects of zinc acexamate on gastric mucosal resistance factors.
    European journal of pharmacology, 1985, Feb-26, Volume: 109, Issue:2

    Topics: Aminocaproates; Aminocaproic Acid; Animals; Female; Gastric Mucosa; Mucus; Necrosis; Rats; Rats, Inb

1985