aminocaproic acid has been researched along with Seizures in 8 studies
Aminocaproic Acid: An antifibrinolytic agent that acts by inhibiting plasminogen activators which have fibrinolytic properties.
6-aminohexanoic acid : An epsilon-amino acid comprising hexanoic acid carrying an amino substituent at position C-6. Used to control postoperative bleeding, and to treat overdose effects of the thrombolytic agents streptokinase and tissue plasminogen activator.
Seizures: Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of brain cells. Clinical manifestations include abnormal motor, sensory and psychic phenomena. Recurrent seizures are usually referred to as EPILEPSY or seizure disorder.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To investigate the incidence of postoperative generalized seizures in patients undergoing aortic valve replacement (AVR) under extracorporeal circulation, who received either high-dose tranexamic acid (TXA) or epsilon aminocaproic acid (EACA) as an antifibrinolytic agent." | 7.77 | High-dose tranexamic acid is related to increased risk of generalized seizures after aortic valve replacement. ( Beyersdorf, F; Keyl, C; Lehane, C; Stampf, S; Trenk, D; Uhl, R; Wiesenack, C, 2011) |
| "Postoperative seizures occurred significantly more frequently in TXA patients (7." | 5.37 | Seizures after open heart surgery: comparison of ε-aminocaproic acid and tranexamic acid. ( Breuer, T; Gertler, R; Knorr, J; Lange, R; Macguill, M; Martin, K; Tassani, P; Wiesner, G, 2011) |
| "This multicenter international experience of pediatric craniofacial surgery reports no increase in seizures or thromboembolic events in those that received antifibrinolytics (tranexamic acid and epsilon-aminocaproic acid) versus those that did not." | 4.12 | Safety of antifibrinolytics in 6583 pediatric patients having craniosynostosis surgery: A decade of data reported from the multicenter Pediatric Craniofacial Collaborative Group. ( Benzon, HA; Goobie, SM; King, MR; Nelson, O; Pérez-Pradilla, C; Staffa, SJ; Stricker, PA, 2022) |
| "To investigate the incidence of postoperative generalized seizures in patients undergoing aortic valve replacement (AVR) under extracorporeal circulation, who received either high-dose tranexamic acid (TXA) or epsilon aminocaproic acid (EACA) as an antifibrinolytic agent." | 3.77 | High-dose tranexamic acid is related to increased risk of generalized seizures after aortic valve replacement. ( Beyersdorf, F; Keyl, C; Lehane, C; Stampf, S; Trenk, D; Uhl, R; Wiesenack, C, 2011) |
| "Although the fourfold risk for seizures using TXA was not significant, we currently use EACA in paediatric cardiac surgery." | 1.37 | Tranexamic acid versus ɛ-aminocaproic acid: efficacy and safety in paediatric cardiac surgery. ( Breuer, T; Gertler, R; Hapfelmeier, A; Hess, J; Lange, R; Martin, K; Schreiber, C; Wiesner, G, 2011) |
| "Postoperative seizures occurred significantly more frequently in TXA patients (7." | 1.37 | Seizures after open heart surgery: comparison of ε-aminocaproic acid and tranexamic acid. ( Breuer, T; Gertler, R; Knorr, J; Lange, R; Macguill, M; Martin, K; Tassani, P; Wiesner, G, 2011) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (12.50) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 6 (75.00) | 24.3611 |
| 2020's | 1 (12.50) | 2.80 |
| Authors | Studies |
|---|---|
| King, MR | 1 |
| Staffa, SJ | 1 |
| Stricker, PA | 1 |
| Pérez-Pradilla, C | 1 |
| Nelson, O | 1 |
| Benzon, HA | 1 |
| Goobie, SM | 1 |
| Martin, K | 2 |
| Breuer, T | 2 |
| Gertler, R | 2 |
| Hapfelmeier, A | 1 |
| Schreiber, C | 1 |
| Lange, R | 2 |
| Hess, J | 1 |
| Wiesner, G | 2 |
| Knorr, J | 1 |
| Macguill, M | 1 |
| Tassani, P | 1 |
| Keyl, C | 1 |
| Uhl, R | 1 |
| Beyersdorf, F | 1 |
| Stampf, S | 1 |
| Lehane, C | 1 |
| Wiesenack, C | 1 |
| Trenk, D | 1 |
| Goldstone, AB | 1 |
| Bronster, DJ | 1 |
| Chikwe, J | 1 |
| Wu, YH | 1 |
| Wu, ML | 1 |
| Lin, CC | 1 |
| Chu, WL | 1 |
| Yang, CC | 1 |
| Lin, RT | 1 |
| Deng, JF | 1 |
| Lecker, I | 1 |
| Wang, DS | 1 |
| Romaschin, AD | 1 |
| Peterson, M | 1 |
| Mazer, CD | 1 |
| Orser, BA | 1 |
| Yamaura, A | 1 |
| Nakamura, T | 1 |
| Makino, H | 1 |
| Hagihara, Y | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Outcome Impact of Different Tranexamic Acid Regimen in Cardiac Surgery With Cardiopulmonary Bypass (the OPTIMAL Study)[NCT03782350] | Phase 4 | 3,079 participants (Actual) | Interventional | 2018-12-26 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
8 other studies available for aminocaproic acid and Seizures
| Article | Year |
|---|---|
Safety of antifibrinolytics in 6583 pediatric patients having craniosynostosis surgery: A decade of data reported from the multicenter Pediatric Craniofacial Collaborative Group.
Topics: Aminocaproic Acid; Antifibrinolytic Agents; Blood Loss, Surgical; Child; Craniosynostoses; Humans; I | 2022 |
Tranexamic acid versus ɛ-aminocaproic acid: efficacy and safety in paediatric cardiac surgery.
Topics: Aminocaproic Acid; Antifibrinolytic Agents; Blood Transfusion; Cardiac Surgical Procedures; Cardiopu | 2011 |
Seizures after open heart surgery: comparison of ε-aminocaproic acid and tranexamic acid.
Topics: Aged; Aminocaproic Acid; Anesthesia; Antifibrinolytic Agents; Blood Loss, Surgical; Cardiac Surgical | 2011 |
High-dose tranexamic acid is related to increased risk of generalized seizures after aortic valve replacement.
Topics: Aged; Aged, 80 and over; Aminocaproic Acid; Antifibrinolytic Agents; Aortic Valve; Drug Administrati | 2011 |
Seizures after adult cardiac surgery.
Topics: Aminocaproic Acid; Antifibrinolytic Agents; Cardiac Surgical Procedures; Female; Humans; Male; Posto | 2011 |
Determination of caprolactam and 6-aminocaproic acid in human urine using hydrophilic interaction liquid chromatography-tandem mass spectrometry.
Topics: Adult; Aminocaproic Acid; Caprolactam; Chromatography, Liquid; Cimetidine; Drug Interactions; Drug S | 2012 |
Tranexamic acid concentrations associated with human seizures inhibit glycine receptors.
Topics: Adult; Aged; Aged, 80 and over; Aminocaproic Acid; Animals; Anticonvulsants; Aprotinin; Binding, Com | 2012 |
Cerebral complication of antifibrinolytic therapy in the treatment of ruptured intracranial aneurysm. Animal experiment and a review of literature.
Topics: Aminocaproates; Aminocaproic Acid; Animals; Blood Pressure; Cerebral Cortex; Cisterna Magna; Cyclohe | 1980 |