aminocaproic acid has been researched along with Ischemic Attack, Transient in 9 studies
Aminocaproic Acid: An antifibrinolytic agent that acts by inhibiting plasminogen activators which have fibrinolytic properties.
6-aminohexanoic acid : An epsilon-amino acid comprising hexanoic acid carrying an amino substituent at position C-6. Used to control postoperative bleeding, and to treat overdose effects of the thrombolytic agents streptokinase and tissue plasminogen activator.
Ischemic Attack, Transient: Brief reversible episodes of focal, nonconvulsive ischemic dysfunction of the brain having a duration of less than 24 hours, and usually less than one hour, caused by transient thrombotic or embolic blood vessel occlusion or stenosis. Events may be classified by arterial distribution, temporal pattern, or etiology (e.g., embolic vs. thrombotic). (From Adams et al., Principles of Neurology, 6th ed, pp814-6)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Postoperative seizures occurred significantly more frequently in TXA patients (7." | 5.37 | Seizures after open heart surgery: comparison of ε-aminocaproic acid and tranexamic acid. ( Breuer, T; Gertler, R; Knorr, J; Lange, R; Macguill, M; Martin, K; Tassani, P; Wiesner, G, 2011) |
| "The incidence and severity of cerebral vasospasm and hydrocephalus following induced subarachnoid hemorrhage in an experimental group of animals that subsequently received epsilon-aminocaproic acid was compared to that seen in a control group that received no antifibrinolytic therapy." | 3.67 | An experimental study of the influence of antifibrinolytic therapy on post-subarachnoid-hemorrhagic cerebral vasospasm and hydrocephalus. ( Dujovny, M; Heros, RC; Kenning, JA; Latchaw, RE; Nelson, D, 1984) |
| "Patients suffering from a subarachnoid hemorrhage who were admitted to the Neurosurgical Unit of the Royal Perth Hospital during the period 1971 to 1979 were assessed with regard to the effectiveness of preoperative treatment with epsilon-aminocaproic acid, kanamycin, and reserpine." | 3.66 | Medical management of patients following a ruptured cerebral aneurysm, with epsilon-aminocaproic acid, kanamycin, and reserpine. ( Knuckey, NW; Stokes, BA, 1982) |
| "Postoperative seizures occurred significantly more frequently in TXA patients (7." | 1.37 | Seizures after open heart surgery: comparison of ε-aminocaproic acid and tranexamic acid. ( Breuer, T; Gertler, R; Knorr, J; Lange, R; Macguill, M; Martin, K; Tassani, P; Wiesner, G, 2011) |
| "The incidence of hydrocephalus or symptomatic vasospasm was not unduly elevated in patients receiving preoperative EACA." | 1.30 | Reducing the risk of rebleeding before early aneurysm surgery: a possible role for antifibrinolytic therapy. ( Horner, TG; Leipzig, TJ; Redelman, K, 1997) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 7 (77.78) | 18.7374 |
| 1990's | 1 (11.11) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (11.11) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Martin, K | 1 |
| Knorr, J | 1 |
| Breuer, T | 1 |
| Gertler, R | 1 |
| Macguill, M | 1 |
| Lange, R | 1 |
| Tassani, P | 1 |
| Wiesner, G | 1 |
| Solomon, RA | 1 |
| Post, KD | 1 |
| McMurtry, JG | 1 |
| Rosenwasser, RH | 1 |
| Buchheit, WA | 1 |
| Truex, RC | 1 |
| Kenning, JA | 1 |
| Heros, RC | 1 |
| Dujovny, M | 1 |
| Latchaw, RE | 1 |
| Nelson, D | 1 |
| Knuckey, NW | 1 |
| Stokes, BA | 1 |
| Leipzig, TJ | 1 |
| Redelman, K | 1 |
| Horner, TG | 1 |
| Peerless, SJ | 1 |
| Langtitt, TW | 1 |
| White, RP | 1 |
| Robertson, JT | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Outcome Impact of Different Tranexamic Acid Regimen in Cardiac Surgery With Cardiopulmonary Bypass (the OPTIMAL Study)[NCT03782350] | Phase 4 | 3,079 participants (Actual) | Interventional | 2018-12-26 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
9 other studies available for aminocaproic acid and Ischemic Attack, Transient
| Article | Year |
|---|---|
Seizures after open heart surgery: comparison of ε-aminocaproic acid and tranexamic acid.
Topics: Aged; Aminocaproic Acid; Anesthesia; Antifibrinolytic Agents; Blood Loss, Surgical; Cardiac Surgical | 2011 |
Depression of circulating blood volume in patients after subarachnoid hemorrhage: implications for the management of symptomatic vasospasm.
Topics: Adult; Aged; Aminocaproic Acid; Antifibrinolytic Agents; Blood Volume; Cerebral Angiography; Dexamet | 1984 |
Management of subarachnoid hemorrhage.
Topics: Adolescent; Adult; Aminocaproic Acid; Antihypertensive Agents; Child; Cimetidine; Dexamethasone; Hum | 1984 |
An experimental study of the influence of antifibrinolytic therapy on post-subarachnoid-hemorrhagic cerebral vasospasm and hydrocephalus.
Topics: Aminocaproates; Aminocaproic Acid; Animals; Cerebral Angiography; Cerebral Hemorrhage; Hydrocephalus | 1984 |
Medical management of patients following a ruptured cerebral aneurysm, with epsilon-aminocaproic acid, kanamycin, and reserpine.
Topics: Aminocaproates; Aminocaproic Acid; Drug Therapy, Combination; Female; Humans; Intracranial Aneurysm; | 1982 |
Reducing the risk of rebleeding before early aneurysm surgery: a possible role for antifibrinolytic therapy.
Topics: Adult; Aged; Aged, 80 and over; Aminocaproic Acid; Aneurysm, Ruptured; Antifibrinolytic Agents; Huma | 1997 |
Pre- and postoperative management of cerebral aneurysms.
Topics: Aminocaproic Acid; Brain Edema; Humans; Hydrocephalus; Hypertension; Intracranial Aneurysm; Ischemic | 1979 |
Conservative care of intracranial hemorrhage.
Topics: Aminocaproic Acid; Blood Pressure; Brain Edema; Cerebral Hemorrhage; Humans; Hydrocephalus; Hyperton | 1977 |
Role of plasmin, thrombin, and antithrombin III as etiological factors in delayed cerebral vasospasm.
Topics: Aminocaproic Acid; Animals; Antithrombin III; Aprotinin; Basilar Artery; Dogs; Female; Fibrinogen; F | 1985 |